CN106880356A - A kind of magnetic resonance time delay imaging method - Google Patents
A kind of magnetic resonance time delay imaging method Download PDFInfo
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- CN106880356A CN106880356A CN201710143229.4A CN201710143229A CN106880356A CN 106880356 A CN106880356 A CN 106880356A CN 201710143229 A CN201710143229 A CN 201710143229A CN 106880356 A CN106880356 A CN 106880356A
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Abstract
The invention discloses a kind of magnetic resonance time delay imaging method, it belongs to magnetic resonance imaging arts, comprises the following steps：The frequency line of the M bar different frequencies in the frequency range in the K spaces for choosing the MRI of detection object；Setup time axle, is sequentially provided with N number of timing node on a timeline, and each timing node is corresponding with a frequency line；Frequency line corresponding with the timing node in the MRI of acquisition testing object；Choose the timing node that some time node is imaged as magnetic resonance time delay；Generation detection object corresponding MRI in the timing node that each magnetic resonance time delay is imaged, constitutes the time delay image of the detection object；Each timing node of the invention only gathers a frequency line in the K spaces of MRI, greatly reduces magnetic resonance time delay imaging for the loss of magnetic resonance equipment, reduces use cost；Reduce influence of the magnetic resonance equipment to the radio-frequency pulse of measurement object, it is ensured that the normal development of measurement object.
Description
Technical field
The present invention relates to magnetic resonance imaging arts, and in particular to a kind of magnetic resonance time delay imaging method.
Background technology
Magnetic resonance imaging is typically a kind of timely imaging method, for the object to be checked, by running appropriate sweeping
Sequence is retouched, within the time of several seconds to a few minutes, enough K space datas is collected, the reconstruction of image is then carried out, you can
Obtain the image of inspected object.So-called K spaces are dual spaces of the ordinary space under fourier conversion, are mainly used in
Magnetic shakes the imaging analysis of radiography.Now, MR imaging method can be used for animals and plants imaging.In animals and plants imaging research, have
One class method is the process for needing to monitor animals and plants change in long term, such as the sprouting and growth of seed, the growth course of embryo etc.,
These processes are relatively slow, short several days, the several months long, for this class object monitoring when, time delay imaging be it is a kind of very fit
The method of conjunction.So-called time delay imaging, that is, " snapshot " often said, are exactly in a short time scale, when playing long
Between yardstick image, be a kind of imaging method of time compression.By the method for magnetic resonance imaging, animals and plants growth course is gathered
Time delay image, be exactly so-called magnetic resonance time delay imaging.
Compared with animals and plants growth course, the time of magnetic resonance single pass is relatively brief, it is impossible to catch animals and plants development
Overall process.Traditional imaging method is exactly in animals and plants growth course, using selected sequence, regularly once to be swept
Retouch, animals and plants image at that time can be obtained.By multiple scanning, substantial amounts of image can be obtained, these images are carried out
Dynamic play, it is possible to obtain the time delay image section of animals and plants development.But, this method lacks flexibility, it is impossible to rebuild
The image of any time, if fixed time interval is too small, although can accomplish that time proximity is continuously gathered, but to the loss of equipment
Excessive and intensive gatherer process will apply excessive radio-frequency pulse and gradient magnetic to detected object, may be to quilt
Detection object produces influence, causes the data of detection not objective enough.
The content of the invention
For the problems of in the prior art, a kind of magnetic resonance time delay imaging method that the present invention is provided can be right
Detected object carries out time proximity and continuously checks, and the image of any time node can be rebuild in the later stage is processed,
And finer observational study can be carried out to time slice interested by regulating time compression ratio.
To achieve these goals, the technical solution adopted by the present invention is as follows：
A kind of magnetic resonance time delay imaging method, comprises the following steps：
The frequency line of the M bar different frequencies in the frequency range in the K spaces for choosing the MRI of detection object, M is
Integer and M are more than or equal to 2, and a frequency line is the data wire of a certain frequency in K spaces, specific by all or part of M bars
The K spaces that the frequency line of frequency is constituted can be reduced into MRI；
Setup time axle, is sequentially provided with N number of timing node on the time axis, and N is for integer and N is more than or equal to M, each
The timing node is corresponding with a frequency line so that the timing node of each is to that should have a frequency for CF
Line；
When the time certain the described timing node on the time shaft is reached, with the method acquisition testing of magnetic resonance imaging
The frequency line corresponding with timing node this described in the MRI of object；
The timing node that some timing nodes are imaged as magnetic resonance time delay is chosen along the time shaft, each magnetic is total to
A time point in the as magnetic resonance time delay imaging of the timing node of time delay of shaking imaging, by controlling what magnetic resonance time delay was imaged
The selection amount of timing node can control the time degree of compression that magnetic resonance time delay is imaged；
Detection object is generated based on the corresponding frequency line of timing node of magnetic resonance time delay imaging every
Corresponding MRI during the timing node of one magnetic resonance time delay imaging, and then constitute the time delay of the detection object
Image.
As a kind of perferred technical scheme, the M in the frequency range in the K spaces for choosing the MRI of detection object
The method of the frequency line of bar different frequency is：The frequency line is equally spaced or according to preceding according to the frequency range in the K spaces
Phase sample image sets different distribution densities, early stage sample be to the MRI sample of the advance collection of detection object or
It is the MRI sample with detection object close to other detection objects.
As a kind of perferred technical scheme, the M in the frequency range in the K spaces for choosing the MRI of detection object
The method of the frequency line of bar different frequency is when setting different distribution densities according to early stage sample image, if the sample graph
The tendency of changes of picture changes in contrast, then encrypt the distribution of the frequency line in the K space low-frequencies region；If the sample
The tendency of changes of this image then encrypts the distribution of the frequency line in the K spatial high-frequencies region in the change of form；Sample graph
The tendency of changes of picture changes in contrast or metamorphosis can be determined by artificial judgment mode.
As a kind of perferred technical scheme, zero frequency line of the frequency line of the M bars different frequency on K spaces is symmetrical
Distribution.
As a kind of perferred technical scheme, the method for N number of timing node being sequentially provided with the time axis is：It is described
Timing node equidistantly distributed or sets different distribution densities, early stage sample according to early stage sample image on the time axis
It is to the MRI sample of the advance collection of detection object or is magnetic resonance with detection object close to other detection objects
Image pattern.
As a kind of perferred technical scheme, when the method for being sequentially provided with N number of timing node on the time axis is root
When setting different distribution densities according to early stage sample image, if sample image described in certain time period on the time axis
Change then encrypts distribution of the timing node in this time period more than the average value of sample image change；If institute
State the average value of the change less than sample image change of sample image described in certain time period on time shaft, then it is loose described
Distribution of the timing node in this time period；The change of sample image can be by artificial judgment mode or by relatively more current sample
Variation of image grayscale speed determines with the mode of sample image gray scale mean change speed.
As a kind of perferred technical scheme, the frequency of the corresponding frequency line of the described timing nodes of continuous M is equal
Differ.
As a kind of perferred technical scheme, the corresponding frequency line of timing node being imaged with the magnetic resonance time delay
Based on generate detection object corresponding MRI in the timing node that each described magnetic resonance time delay is imaged, and then
The method for constituting the time delay image of the detection object is：The timing node for choosing a magnetic resonance time delay imaging is corresponding
The frequency line of frequency line and closest other of the timing node at most M-1 bars different frequency being imaged with the magnetic resonance time delay
Constitute the detection object to should magnetic resonance time delay imaging timing node MRI K spaces and carry out figure
As rebuilding, the time point corresponding MRI of each magnetic resonance time delay imaging is sequentially generated, along the magnetic resonance
Time delay image of the time point of the time delay imaging sequential combination on the time axis into the detection object.
Beneficial effects of the present invention show：
1st, each timing node of the invention only gathers a frequency line in the K spaces of MRI, greatly reduces
Magnetic resonance time delay is imaged the loss for magnetic resonance equipment, reduces use cost；And magnetic resonance equipment is also reduced to surveying
The influence of the radio-frequency pulse and gradient magnetic of object is measured, it is ensured that the normal development of measurement object, so as to improve the standard of image
True property.
2nd, frequency distribution of the present invention by early stage sample to the MRI K spaces of measurement object is optimized, can
To protrude the change of contrast or form in measurement object growth course, it is easy to carry out finely the MRI of measurement object
Observational study.
3rd, distribution of the present invention by early stage sample to measurement object timing node on a timeline is optimized, Ke Yizeng
Plus measurement object is in the timing node quantity of the period for changing greatly, the quantity of period reconstruction image when improving later stage treatment,
It is easy to carry out fine observational study to interested time slice.
Brief description of the drawings
Fig. 1 is a kind of indicative flowchart of magnetic resonance time delay imaging method of the invention.
Specific embodiment
For the ease of it will be appreciated by those skilled in the art that the present invention is further illustrated below in conjunction with the accompanying drawings.
As shown in figure 1, the present invention proposes a kind of magnetic resonance time delay imaging method, comprise the following steps：
The frequency line of the M bar different frequencies in the frequency range in the K spaces for choosing the MRI of detection object, M is
Integer and M are more than or equal to 2；
Setup time axle, is sequentially provided with N number of timing node on the time axis, and N is for integer and N is more than or equal to M, each
The timing node is corresponding with a frequency line；
When the time certain the described timing node on the time shaft is reached, with the method acquisition testing of magnetic resonance imaging
The frequency line corresponding with timing node this described in the MRI of object；
The timing node that some timing nodes are imaged as magnetic resonance time delay is chosen along the time shaft；
Detection object is generated based on the corresponding frequency line of timing node of magnetic resonance time delay imaging every
Corresponding MRI during the timing node of one magnetic resonance time delay imaging, and then constitute the time delay of the detection object
Image.
Wherein, the frequency line of the M bar different frequencies in the frequency range in the K spaces for choosing the MRI of detection object
Method be：Frequency line is equally spaced or close according to the different distributions of early stage sample image setting according to the frequency range in K spaces
Degree, early stage sample is to the MRI sample of the advance collection of detection object or is right close to other detections with detection object
The MRI sample of elephant, for the detection object without early stage sample, can using by frequency line K spaces frequency model
It is equally spaced in enclosing；For the detection object for having early stage sample, can be by the analysis reasonable adjusting frequency line to early stage sample
Distribution mode in the frequency range in K spaces is easy to the fine observational study for having emphasis；
The side of the frequency line of the M bar different frequencies in the frequency range in the K spaces for choosing the MRI of detection object
When method is according to early stage sample image setting different distribution densities, if the tendency of changes of sample image changes in contrast,
The then distribution of the frequency line in encryption K space low-frequencies region；If the tendency of changes of sample image encrypts K in the change of form
The distribution of the frequency line in spatial high-frequency region；The tendency of changes of sample image changes in contrast or metamorphosis can be by people
For judgment mode determines；
Zero frequency line of the frequency line of M bar different frequencies on K spaces is symmetrical；
The method for being sequentially provided with N number of timing node on the time axis is：The timing node is on the time axis
Equidistantly distributed sets different distribution densities according to early stage sample image, and early stage sample is the advance collection to detection object
MRI sample or be MRI sample with detection object close to other detection objects；
When the method for being sequentially provided with N number of timing node on the time axis is to set different according to early stage sample image
During distribution density, if the change of sample image described in certain time period on the time axis changes more than the sample image
Average value, then encrypt distribution of the timing node in this time period；If described in certain time period on the time axis
The change of sample image is less than the average value of sample image change, then the loose timing node dividing in this time period
Cloth；The change of sample image can be by artificial judgment mode or by relatively more current sample image grey scale change speed and sample
The mode of gradation of image mean change speed determines；
The frequency of the corresponding frequency line of the continuous M timing node is differed；
Detection object is generated based on the corresponding frequency line of timing node of magnetic resonance time delay imaging every
Corresponding MRI during the timing node of one magnetic resonance time delay imaging, and then constitute the time delay of the detection object
The method of image is：The corresponding frequency line of timing node and prolong with the magnetic resonance that the magnetic resonance time delay of selection one is imaged
When other closest at most M-1 bars different frequencies of the timing node that is imaged frequency line constitute the detection object to should
The K spaces of the MRI of the timing node of the magnetic resonance time delay imaging simultaneously carry out image reconstruction, sequentially generate each
The time point corresponding MRI of the magnetic resonance time delay imaging, along the time point of magnetic resonance time delay imaging described
The time delay image of sequential combination on time shaft into the detection object.
Above content is only to structure example of the invention and explanation, affiliated those skilled in the art
Various modifications or supplement are made to described specific embodiment or is substituted using similar mode, without departing from invention
Structure or surmount scope defined in the claims, protection scope of the present invention all should be belonged to.
Claims (8)
1. a kind of magnetic resonance time delay imaging method, it is characterized in that, comprise the following steps：
The frequency line of the M bar different frequencies in the frequency range in the K spaces for choosing the MRI of detection object, M is integer
And M is more than or equal to 2；
Setup time axle, is sequentially provided with N number of timing node on the time axis, and N is integer and N is more than or equal to M, described in each
Timing node is corresponding with a frequency line；
When the time certain the described timing node on the time shaft is reached, with the method acquisition testing object of magnetic resonance imaging
MRI in the frequency line corresponding with timing node this described；
The timing node that some timing nodes are imaged as magnetic resonance time delay is chosen along the time shaft；
Detection object is generated based on the corresponding frequency line of timing node of magnetic resonance time delay imaging at each
Corresponding MRI during the timing node of the magnetic resonance time delay imaging, and then constitute the time delay shadow of the detection object
Picture.
2. a kind of magnetic resonance time delay imaging method according to claim 1, it is characterized in that, choose the magnetic resonance of detection object
The method of the frequency line of the M bar different frequencies in the frequency range in the K spaces of image is：The frequency line is according to the K spaces
Frequency range be equally spaced or different distribution densities set according to early stage sample image.
3. a kind of magnetic resonance time delay imaging method according to claim 2, it is characterized in that, choose the magnetic resonance of detection object
The method of the frequency line of the M bar different frequencies in the frequency range in the K spaces of image is to set different according to early stage sample image
Distribution density when, if the tendency of changes of the sample image in contrast change, encrypt the K space low-frequencies region
The distribution of the frequency line；If the tendency of changes of the sample image is in the change of form, the K spatial high-frequencies area is encrypted
The distribution of the frequency line in domain.
4. a kind of magnetic resonance time delay imaging method according to claim 1, it is characterized in that, the frequency of the M bars different frequency
Zero frequency line of the rate line on K spaces is symmetrical.
5. a kind of magnetic resonance time delay imaging method according to claim 1, it is characterized in that, set successively on the time axis
The method for having N number of timing node is：Timing node equidistantly distributed or according to early stage sample image on the time axis
The different distribution density of setting.
6. a kind of magnetic resonance time delay imaging method according to claim 5, it is characterized in that, when on the time axis successively
The method for being provided with N number of timing node is when setting different distribution densities according to early stage sample image, if in the time shaft
On certain time period described in sample image change more than the sample image change average value, then encrypt the timing node
In the distribution of this time period；If the change of sample image described in certain time period on the time axis is less than the sample graph
As the average value of change, then distribution of the loose timing node in this time period.
7. a kind of magnetic resonance time delay imaging method according to claim 1, it is characterized in that, continuous M it is described when segmentum intercalaris
The frequency of the corresponding frequency line of point is differed.
8. a kind of magnetic resonance time delay imaging method according to claim 1, it is characterized in that, it is imaged with the magnetic resonance time delay
The corresponding frequency line of timing node based on generate the time that detection object is imaged in each described magnetic resonance time delay
Corresponding MRI during node, and then constitute the method for the time delay image of the detection object and be：Choose the magnetic
Resonance time delay imaging the corresponding frequency line of timing node and with the magnetic resonance time delay be imaged timing node it is closest
The frequency line of other at most M-1 bars different frequencies constitute the detection object to should the magnetic resonance time delay imaging when segmentum intercalaris
The K spaces of the MRI of point simultaneously carry out image reconstruction, sequentially generate the time point of each magnetic resonance time delay imaging
Corresponding MRI, the time point sequential combination on the time axis being imaged along the magnetic resonance time delay is into the inspection
Survey the time delay image of object.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6121775A (en) * | 1998-06-16 | 2000-09-19 | Beth Israel Deaconess Medical Center, Inc. | MRI imaging method and apparatus |
| CN102540116A (en) * | 2011-12-08 | 2012-07-04 | 中国科学院深圳先进技术研究院 | Magnetic resonance imaging method and system |
| CN105259525A (en) * | 2015-10-28 | 2016-01-20 | 北京大学 | Dynamic contrast enhanced magnetic resonance fast imaging method based on neighborhood sharing compression sensing |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6121775A (en) * | 1998-06-16 | 2000-09-19 | Beth Israel Deaconess Medical Center, Inc. | MRI imaging method and apparatus |
| CN102540116A (en) * | 2011-12-08 | 2012-07-04 | 中国科学院深圳先进技术研究院 | Magnetic resonance imaging method and system |
| CN105259525A (en) * | 2015-10-28 | 2016-01-20 | 北京大学 | Dynamic contrast enhanced magnetic resonance fast imaging method based on neighborhood sharing compression sensing |
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