CN106860088B

CN106860088B - A kind of skin-whitening and scar-removing skin care product and preparation method thereof

Info

Publication number: CN106860088B
Application number: CN201710071721.5A
Authority: CN
Inventors: 王乃龙; 李耀钊; 石蓓君
Original assignee: Mentholatum China Pharmaceuticals Co Ltd
Current assignee: Mentholatum China Pharmaceuticals Co Ltd
Priority date: 2017-02-09
Filing date: 2017-02-09
Publication date: 2021-04-13
Anticipated expiration: 2037-02-09
Also published as: CN106860088A

Abstract

The invention discloses a whitening and scar-removing skin care product, comprising the following ingredients by weight percentage: 0.01-5% 3-o-ethyl ascorbic acid; 0.01-5% tranexamic acid; 0.001-4% carnosine; 0.001-3% schisandra chinensis extract; 0.001-1% salicylic acid; 0.1-1% allantoin; 0.001-1% retinol palmitate; 0.01-10% anhydrous ethanol; 0.001-2% nephrolepis extract; auxiliary materials, remainder. The complex has multiple functions such as moisturizing, repairing, anti-wrinkle, whitening, yellowing, redness, and scar removal. The invention also discloses a preparation method of the whitening and scar-removing skin care product, which has few steps, is simple and safe to operate, and has low cost. The invention also discloses a facial whitening and scar-removing cream, a multi-protection isolation essence, and a whitening cleanser, as well as their preparation methods.

Description

Skin care product for whitening and removing scars and preparation method thereof

Technical Field

The invention relates to the technical field of cosmetics, in particular to a skin care product for whitening and removing scars and a preparation method thereof.

Background

The skin plays an important barrier role in the human body, and it can protect the human body from external factors. This barrier function is a protective function that protects the human body from various external stimuli (e.g., chemicals, atmospheric pollutants, dry environment and ultraviolet rays, physical damage) and prevents excessive water loss from the body through the skin.

When the skin meets external stimulation and physical injury, the skin barrier is damaged, and various physical and chemical indexes of the skin are abnormal, such as skin moisture reduction, dryness, inflammatory reaction, atopic dermatitis and contact dermatitis; the skin is abnormally deposited with melanin, the skin is dark, the skin elastin and the collagen are lost, and finally, the surface of the skin can form color spots, the erythema inflammatory reaction and the keratinocyte abnormal keratinization and aging. When the injury is serious, the skin can generate inflammatory factors and a large number of free radicals, so that the skin melanin is deposited, and finally, dark purple scars are generated, and the beauty is affected.

The scar is the serious injury of skin soft tissue which can not be completely and normally repaired by self after the skin tissue of human body is injured by various external wounds and is damaged by physical, biological, chemical and other factors and acts on the skin soft tissue of human body, and is replaced and repaired by fibrous tissue. The skin fiber connective tissue hyperplasia at the wound healing part is formed by filling, connecting, supporting and protecting the surrounding normal tissues.

Appearance classification and manifestation of scars:

1. depressed scars are defects in the dermis layer of the skin primarily due to acne, infection, trauma, surgery, and the like. After severe acne, worm-like and ice cone-like scars can be seen, and after smallpox and chicken pox, pit-like scars can be seen.

2. Raised scars are mostly proliferative lesions of fibroblasts in the dermal layer of the skin after burns, wounds, surgery or repeated infections. It is seen as red and raised, hard, smooth surface with itching and pain, and keloid may expand outwards like crab feet. The raised scar is rich in blood supply, and has more than 2 times of oxygen free radicals and actively proliferating fibroblasts.

3. The mild scar refers to a scar on the superficial layer of skin, which is mostly caused by mild abrasion of skin or superficial dermal burn and scald. Such scars are manifested by surface roughness or changes in pigmentation such as erythema, vitiligo or pigmentation of the skin, and are generally non-functional, but such scars can affect the visual appearance.

Several scar treatment methods currently in common use include: the method can relieve scar hyperplasia and improve appearance, but can not completely repair scars.

Disclosure of Invention

In order to overcome the defects of the prior art, the first object of the invention is to provide a skin care product for whitening and removing scars, wherein the compound has multiple effects of moisturizing, repairing, resisting wrinkles, whitening, removing yellow, removing red, removing scars and the like.

The second purpose of the invention is to provide a preparation method of the whitening scar-removing skin care product, which has the advantages of few steps, simple and safe operation and low cost.

The third purpose of the invention is to provide the face cream with the effects of restoring and whitening the face and removing the yellow marks, which has good moisturizing, whitening and yellow removing effects and can well repair the skin.

The fourth purpose of the invention is to provide a preparation method of the face cream with the effects of restoring complexion, whitening and removing marks, which has the advantages of few steps, simple process, safe operation and low cost.

The fifth purpose of the invention is to provide multiple protection and isolation essence which can effectively prevent ultraviolet rays from damaging skin, keep moisture and ventilate, does not block pores and does not cause acne.

The sixth purpose of the invention is to provide a preparation method of the multiple-protection isolation essence, which has the advantages of few steps, simple process, safe operation and low cost.

The seventh purpose of the invention is to provide the whitening facial cleanser which can go deep into pores, thoroughly clean grease and dirt, keep the skin from being tight after use and have excellent moisturizing and whitening effects.

The eighth purpose of the invention is to provide a preparation method of the whitening facial cleanser, which has the advantages of few steps, simple process, safe operation and low cost.

The first purpose of the invention is realized by adopting the following technical scheme:

a whitening and scar-removing skin care product comprises the following components in percentage by weight:

preferably, the auxiliary material is one or any combination of water, a humectant, a surfactant, an emollient, a sunscreen agent, a thickener and a preservative.

Preferably, the moisturizers comprise polyhydric alcohol moisturizers and polysaccharide moisturizers; the polyalcohol humectant is one or any combination of glycerol, diglycerol, butanediol, propylene glycol, dipropylene glycol, sorbitol, allantoin, polyethylene glycol-400 and PPG-10 methyl glucose ether; the polysaccharide humectant is one or any combination of hyaluronic acid, sodium hyaluronate, pullulan, trehalose and lima bean seed extract; the surfactant is one or any combination of glyceryl stearate citrate, polysorbate-60 and fatty acid soap; the emollient is one or any combination of jojoba oil, isononyl isononanoate, diethylhexyl carbonate, shea butter, vitamin E acetate, octyl methicone and bisabolol; the sunscreen agent is one or any combination of ethylhexyl methoxycinnamate, ethylhexyl triazone, bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylamino hydroxybenzoyl hexyl benzoate, butyl methoxydibenzoyl methane, phenyl dibenzoimidazole tetrasulfonate disodium, methylene bis-benzotriazolyl tetramethylbutylphenol, p-xylylene dicamphor sulfonic acid, zinc oxide, titanium dioxide, octyl salicylate, homosalate and octocrylene; the thickening agent is one or any combination of carbomer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and acryloyl dimethyl ammonium taurate/VP copolymer; the preservative comprises one or any combination of benzoic acid, benzoate, phenoxyethanol and ethylhexyl glycerol.

The skin whitening and scar removing skin care product provided by the invention has the effects of removing skin scars, promoting skin wound healing and fading scars due to the mutual coordination of the components. The scar removing method comprises the following steps:

the first step is as follows: decomposing, removing and replacing aged and fibrotic non-functional scar tissues;

the second step is that: establishing the ecological environment of normal skin, promoting the cell regeneration function, promoting wound healing, increasing the synthesis of collagen, and repairing the skin barrier;

the third step: promoting blood circulation, inhibiting abnormal pigment deposition, restoring normal skin color, and restoring skin health state.

The second purpose of the invention is realized by adopting the following technical scheme:

a preparation method of a skin care product for whitening and removing scars comprises the following steps when the auxiliary material is water:

1) preparation of phase A: placing 3-O-ethyl ascorbic acid, allantoin, tranexamic acid, carnosine, fructus Schisandrae Sphenantherae extract and fructus Viticis negundo extract in a first container at normal temperature, adding water in a certain amount, stirring and dissolving to obtain phase A;

2) preparation of phase B: at normal temperature, placing the formula amount of retinol palmitate and salicylic acid in a second container, then adding the formula amount of ethanol, stirring and dissolving to obtain a phase B;

3) mixing: adjusting the temperature of the phase A and the phase B to 25-35 ℃, then mixing and stirring uniformly to obtain the final product.

The third purpose of the invention is realized by adopting the following technical scheme:

the face-beautifying, whitening and scar-comforting face cream comprises the following components in percentage by mass:

the main components are as follows:

auxiliary materials:

preferably, the complexion-whitening and scar-stroking cream comprises the following components in percentage by mass:

the main components are as follows:

auxiliary materials:

the fourth purpose of the invention is realized by adopting the following technical scheme:

a preparation method of a face cream capable of restoring complexion, whitening and removing marks comprises the following steps:

1) preparing a prefabricated liquid A: adding vitamin E acetate, bisabolol and retinol palmitate with the formula ratio into a first container, and stirring for dissolving to obtain a prefabricated liquid A;

2) preparing a prefabricated liquid B: adding salicylic acid and absolute ethyl alcohol in a formula amount into a second container, and stirring and dissolving to obtain a prefabricated liquid B;

3) preparing a preformance liquid C: dividing the water of the formula amount into two parts, namely a first part of water and a second part of water; adding 3-o-ethyl ascorbic acid, tranexamic acid, carnosine, fructus Schisandrae Sphenantherae extract, fructus Viticis negundo extract, and the first part of water into a third container, stirring and dissolving to obtain a solution C;

4) preparing an oil phase: adding jojoba oil, isononyl isononanoate, diethylhexyl carbonate, shea butter, octyl polymethylsiloxane and glyceryl stearate citrate into a fourth container, heating to 80-85 deg.C, stirring for dissolving to obtain oil phase;

5) preparing an aqueous phase: adding allantoin, sodium hyaluronate, 1, 3-butanediol and the second part of water in a formula amount into a fifth container, heating to 80-85 ℃, and stirring for dissolving to obtain a water phase;

6) emulsification: adding the oil phase into the water phase, homogenizing and stirring for 8-12min, and setting the temperature at 50-55 ℃; then adding the formula amount of acryloyl dimethyl ammonium taurate/VP copolymer, homogenizing, stirring and thickening, adding the prefabricated liquid A when the temperature reaches 50-55 ℃, homogenizing and stirring uniformly; when the temperature is reduced to 40-45 ℃, adding the prepared liquid B and the prepared liquid C, and the phenoxyethanol, the ethylhexyl glycerin and the essence according to the formula ratio, stirring uniformly, and when the temperature is reduced to 30-35 ℃, obtaining the face-beautifying, whitening and trace-comforting cream.

The fifth purpose of the invention is realized by adopting the following technical scheme:

the multiple protection isolation essence comprises the following components in percentage by mass:

the main components are as follows:

auxiliary materials:

preferably, the multiple-protection isolation essence comprises the following components in percentage by mass:

the main components are as follows:

auxiliary materials:

the sixth purpose of the invention is realized by adopting the following technical scheme:

a preparation method of multiple-protection isolation essence comprises the following steps:

1) preparing a prefabricated liquid A: adding vitamin E acetate and retinol palmitate with the formula ratio into a first container, and stirring for dissolving to obtain a prefabricated liquid A;

3) preparing a preformance liquid C: dividing the water of the formula amount into three parts which are respectively marked as first part of water, second part of water and third part of water; adding 3-o-ethyl ascorbic acid, tranexamic acid, carnosine, fructus Schisandrae Sphenantherae extract, fructus Viticis negundo extract, and the first part of water into a third container, stirring and dissolving to obtain a solution C;

4) preparing a prefabricated liquid D: adding arginine with the formula amount and a second part of water into a fourth container, and stirring and dissolving to obtain a prefabricated liquid D;

5) preparing an oil phase: adding ethylhexyl methoxycinnamate, ethylhexyl triazone, bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylamino hydroxybenzoyl hexyl benzoate and polysorbate-60 into a fifth container, heating to 80-85 deg.C, stirring for dissolving to obtain oil phase;

6) preparing an aqueous phase: adding allantoin, sodium hyaluronate, 1, 3-butanediol and glycerol in a formula amount and a third part of water into a sixth container, heating to 80-85 ℃, stirring for dissolving, adding acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer in a formula amount, and dispersing and dissolving to obtain a water phase;

7) emulsification: adding the oil phase into the water phase, homogenizing and stirring for 8-12min, and setting the temperature at 50-55 deg.C; then adding the formula amount of acryloyl dimethyl ammonium taurate/VP copolymer, homogenizing, stirring and thickening; when the temperature reaches 50-55 ℃, adding the prefabricated liquid A and the prefabricated liquid D, and homogenizing and uniformly stirring; when the temperature is reduced to 40-45 ℃, adding the prefabricated liquid B and the prefabricated liquid C, and the phenoxyethanol, the ethylhexyl glycerin and the essence according to the formula ratio, uniformly stirring, and when the temperature is reduced to 30-35 ℃, obtaining the multiple protection isolation essence.

The seventh purpose of the invention is realized by adopting the following technical scheme:

the whitening facial cleanser comprises the following components in percentage by mass:

the main components are as follows:

auxiliary materials:

preferably, the whitening facial cleanser comprises the following components in percentage by mass:

the main components are as follows:

auxiliary materials:

the eighth purpose of the invention is realized by adopting the following technical scheme:

a preparation method of whitening facial cleanser comprises the following steps:

4) preparing an oil phase: adding lauric acid, myristic acid, stearic acid and palmitic acid in the formula amount into a fourth container, and heating for dissolving to obtain an oil phase;

5) preparing an aqueous phase: adding allantoin, glycerol, 1, 3-butanediol, EDTA-2Na, potassium hydroxide and second water in a formula ratio into a fifth container, and stirring for dissolving to obtain a water phase;

6) saponification: and adding the oil phase into the water phase, homogenizing until the soap cluster is opened, stirring and cooling, adding the prefabricated liquid A, the prefabricated liquid B and the prefabricated liquid C when the temperature is reduced to 55-60 ℃, stirring and dissolving, and cooling to 30-35 ℃ to obtain the whitening facial cleanser.

Compared with the prior art, the invention has the beneficial effects that:

(1) the skin care product for whitening and removing scars provided by the invention comprises 8 active ingredients, and the 8 active ingredients can respectively play roles and simultaneously play a synergistic role, so that multiple effects of moisturizing, repairing, resisting wrinkles, whitening, removing yellow, red and scars on skin and the like are achieved. The skin care product for whitening and removing scars can effectively repair skin barriers, promote blood microcirculation, improve the phenomena of dark and reddish skin color and the like, prevent the defect of scars caused by abnormal deposition of melanin due to external stimulation of inflammation, ultraviolet rays and the like, promote wound healing, promote the generation of collagen and elastin of skin and restore the normal physiological function of skin.

(2) The skin care product for whitening and removing scars provided by the invention has the whitening effect and can reduce the formation of melanin from different ways; the skin moisture loss can be prevented, the skin barrier can be repaired, and the moisture can be preserved and locked, so that the skin is in a healthy and full state; the compound can moisturize and lock water, can stimulate the synthesis of skin collagen while repairing skin, enhance the mitosis of cells, improve the activity of enzyme, keep normal keratinization and improve the epithelization; can reduce the damage of the skin caused by light, relieve the substantial photoaging characteristics of the skin such as roughness, wrinkles and extensive abnormal pigmentation, and improve the beauty, such as smoother skin texture, more uniform color and less fine lines; can dispel the dark yellow skin and restore the skin to be clean and white; the components are coordinated with each other, and the effects of removing skin scars, promoting the healing of skin wounds and fading scars can be achieved.

(3) The skin care product for whitening and removing scars provided by the invention can be used as an active ingredient to be applied to various cosmetics such as skin care, sun protection, face cleaning, bathing and the like, and has wide application range and strong practicability.

(4) The whitening scar-removing skin care product provided by the invention has the following working mechanism of scar removal:

1. softening, decomposing, clearing, replacing aged, fibrotic, non-functional scar tissue: salicylic Acid (Salicylic Acid) can reduce adhesion between keratinocytes, thereby exfoliating dead skin cells, softening stratum corneum, and has antibacterial and bacteriostatic effects, and can prevent bacterial infection.

2. Establishing the ecological environment of normal skin, promoting the cell regeneration function, promoting wound healing, increasing the synthesis of collagen, and repairing the skin barrier: retinol Palmitate (Retinyl Palmitate) -vitamin A derivatives, which stimulate collagen synthesis, improve epithelialization, maintain normal keratinization of skin, and promote wound healing by increasing granulation tissue formation and stimulating fibroblast mitosis; allantoin (alantoin) can stimulate the growth of epithelium, enhance the water binding capacity of keratinocytes, improve skin moisturizing ability, enhance skin barrier, and greatly enhance the skin repairing ability due to the cooperation of Allantoin and vitamin A (retinol palmitate); the Extract of Negundo chastetree (Vitex Negundo Extract) is capable of stimulating the natural DNA repair system, activating DNA repair, increasing oxidative stress and resistance and preventing cell death, increasing protein synthesis, and repairing skin barrier.

3. Promoting blood circulation, inhibiting abnormal pigmentation, recovering normal skin color, and restoring skin health: fructus Schisandrae Sphenantherae Extract (Schisandra Sphenanthera Extract) has effects of improving blood vessel microcirculation, inhibiting inflammatory factor, relieving skin tissue irritation and redness, and inhibiting pigmentation due to inflammation, resulting in mottle, scar, and uneven skin color; tranexamic Acid (Tranexamic Acid) can prevent the activity of inflammatory protease (fibrinolysin), inhibit the disorder of epidermal cell function at black spot, restore the high melanocyte to normal state, inhibit inflammation-induced melanin deposition, and inhibit pigmentation caused by scar; 3-O-ethyl ascorbic acid (3-O-ethyl ascorbyl acid), which has small molecular weight, good skin penetration, excellent oxidation resistance, can clear free radicals, reduce melanin, inhibit the activity of tyrosinase, prevent the generation and the continuous deposition of melanin, has whitening effect on the generated melanin, and recovers the normal skin color; carnosine (carnosine) can inhibit protein cross-linking, inhibit glycosylation, remove dark yellow skin, stimulate collagen synthesis, and remove dark yellow skin and white skin.

Drawings

Fig. 1 is a whitening and scar-removing test effect diagram of the whitening and whitening scar-removing cream provided in embodiment 1 of the invention;

fig. 2 is a diagram illustrating the effect of a humidity preservation performance test of the multiple protection isolation essence provided in embodiment 2 of the present invention;

fig. 3 is a whitening test effect graph of the multiple protection isolation essences provided in embodiment 2 of the present invention;

fig. 4 is a whitening test effect chart of the multi-effect whitening facial cleanser provided in embodiment 3 of the invention.

Detailed Description

The invention will be further described with reference to specific embodiments:

Preferably, the moisturizers comprise polyhydric alcohol moisturizers and polysaccharide moisturizers; the polyalcohol humectant is one or any combination of glycerol, diglycerol, butanediol, propylene glycol, dipropylene glycol, sorbitol, allantoin, polyethylene glycol-400 and PPG-10 methyl glucose ether; the polysaccharide humectant is one or any combination of plant mucopolysaccharide humectants such as hyaluronic acid, sodium hyaluronate, pullulan, trehalose and lima bean seed extract; the surfactant is one or any combination of glyceryl stearate citrate, polysorbate-60 and fatty acid soap (obtained by neutralizing lauric acid, myristic acid, stearic acid, palmitic acid and potassium hydroxide); the emollient is one or any combination of jojoba oil, isononyl isononanoate, diethylhexyl carbonate, shea butter, vitamin E acetate, octyl methicone and bisabolol; the sunscreen agent is one or any combination of ethylhexyl methoxycinnamate, ethylhexyl triazone, bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylamino hydroxybenzoyl hexyl benzoate, butyl methoxydibenzoyl methane, phenyl dibenzoimidazole tetrasulfonate disodium, methylene bis-benzotriazolyl tetramethylbutylphenol, p-xylylene dicamphor sulfonic acid, zinc oxide, titanium dioxide, octyl salicylate, homosalate and octocrylene; the thickening agent is one or any combination of carbomer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and acryloyl dimethyl ammonium taurate/VP copolymer; the preservative comprises one or any combination of benzoic acid, benzoate, phenoxyethanol and ethylhexyl glycerol.

Among them, acrylic acid/C10-30 alkanol Acrylate crosspolymer (acrylics C10-30Alkyl Acrylate Cross polymers) is a film forming agent which is commonly used to maintain a dispersed form in water to avoid coagulation, and the formed film can also provide a water-locking function to the product.

The acryloyl dimethyl ammonium taurate/VP copolymer is also called acryloyl dimethyl ammonium taurate/vinyl pyrrolidone copolymer, and belongs to a high molecular surfactant-acrylic polymer; it is solid powder in appearance, or colorless to yellowish liquid; is soluble in water, stable and degradable, and has excellent emulsifying, dispersing, thickening and film forming abilities.

The whitening scar-removing skin care product can inhibit bacteria and kill bacteria: salicylic Acid (Salicylic Acid), originally found in willow bark, has been used as a keratolytic agent and is widely used in the treatment of various skin problems. The salicylic acid can reduce the adhesion degree between keratinocytes, so that dead skin cells can be exfoliated, the stratum corneum can be softened, and the salicylic acid has the effects of sterilization and bacteriostasis and can prevent bacterial infection.

The skin care product for whitening and removing scars has the effects of whitening and reducing the formation of melanin from different ways: tranoxamic Acid (Tranexamic Acid) is also called as phlebotomitis, Tranexamic Acid and the like, belongs to the class of fibrinolysis inhibitors, and reversibly blocks lysine binding sites on plasminogen molecules to cause plasminogen to be transferred to plasmin, thereby effectively inhibiting fibrinolysis and achieving hemostasis. The medical prescription slip for treating the liver spots and the melanin precipitation is found to have the function of whitening the skin unexpectedly in the diagnosis and treatment process. In recent years, tranexamic acid is a whitening component which has been granted and claimed on the aspect of nourishment, and years of clinical research proves that tranexamic acid is a protease inhibitor, can prevent the activity of inflammatory protease (fibrinolysin), inhibits the disorder of epidermal cell functions of black spot parts, enables excited melanocytes to be restored to a normal state, inhibits inflammation-induced melanin deposition, can quickly whiten and lighten spots, repairs skin barriers and enables the skin to present white, soft, bright and crystal-transparent perfect skin.

Meanwhile, the 3-O-ethyl ascorbic acid (3-O-ethyl ascorbyl acid) has a wide application range in cosmetics, has a small molecular weight and good skin penetrating power, and can be used for clearing free radicals and reducing melanin, so that black spots are reduced, melanin precipitation is reduced, and the skin color is bright. In addition, the collagen can be stimulated to grow, and the skin elasticity can be recovered.

The skin care product for whitening and removing scars can keep moisture and lock water and stimulate the synthesis of skin collagen: allantoin (alantoin), which was first used in the sixteen century for topical wound treatment, was discovered by surgeons to stimulate epithelial growth, enhance the ability of keratinocytes to bind water, increase skin moisturization, enhance the skin barrier, and moisturize while repairing dry and damaged skin caused by daily living and external environmental stress, irritation, and the FDA in the united states classified Allantoin as a type i skin protectant. And in cooperation with vitamin a (retinol palmitate), it has a stronger skin-repairing ability.

The whitening and scar-removing skin care product can reduce the damage of the skin to light: skin, epidermal and dermal connective tissue, which is chronically overexposed to sunlight, undergoes slow and cumulative damage. Studies have considered only UVB radiation to be harmful to the skin, and recent studies have shown that UVA also causes severe damage. Both wavelengths can cause erythema, inflammation, increase in proteoglycans and glycosaminoglycans, collagen damage, elastosis, and ultimately increase skin wrinkles, decrease in skin elasticity, and skin aging. The complexes of the invention comprise a vitamin A derivative, retinol Palmitate (Retinyl Palmitate), and a number of controlled clinical studies have evaluated the effect of vitamin A on human photoaged skin. Vitamin A not only reduces the substantial photoaging characteristics of skin such as roughness, wrinkles and extensive abnormal pigmentation, but also improves cosmetic appearance such as smoother skin texture, more uniform color and reduced fine lines.

The skin care product for whitening and removing scars can remove dark yellow skin and restore the skin to be white: with increasing age, glucose is increasingly bound to proteins, AGEs (glycosylated end products) are formed, glycosylation leads to protein cross-linking, and loss of cell division capacity is one of the typical consequences of glycosylation. The skin gradually appears brownish yellow and has reduced toughness, a process known as the maillard reaction. Carnosine (carnosine) is naturally equivalent to alanyl-L-histidine in human body, and can inhibit protein cross-linking, inhibit glycosylation reaction, remove skin dark yellow, stimulate collagen synthesis, remove skin dark yellow, and restore skin whiteness.

The skin care product for whitening and removing scars can inhibit redness: schisandra Sphenanthera Extract (Schisandra Sphenkhara Extract) is an Extract obtained by collecting Schisandra Sphenanthera wild berries similar to blackcurrant in appearance and subjected to a green sustainable extraction process at an altitude of 3000 m. Inhibiting inflammatory factor, reducing vasodilatation, improving microcirculation, preventing formation of red blood filament, and removing skin redness.

Example 1

The face-beautifying, whitening and scar-comforting face cream comprises the following components in percentage by weight:

the main components are as follows:

auxiliary materials:

the preparation method of the face cream for restoring the complexion, whitening and removing marks sequentially comprises the following steps:

TestingExample 1

The whitening scar-removing testing method comprises the following steps:

the experimental principle is as follows: the whitening and scar-removing efficacy of the product is evaluated by testing the change amount of skin melanin at scars before and after the product is used by a volunteer by using a human skin tester MAP 580.

Subject: there were visible scars on the arms of 6 patients, 4 of whom were male and 2 of whom were aged 25-35 years.

The experimental method comprises the following steps: in the area with fixed arm scars, the same amount of the whitening and beautifying cream obtained in the example 1 is used, and the amount is 2mg/cm²The skin whitening and scar removing cream is used for 3 times a day in the morning, the noon and the evening and is continuously used for 28 days, the skin content of scars and the skin content of blanks on 0 th day, 7 th day, 14 th day, 21 st day and 28 th day of a volunteer are tested by using a human skin tester, and the skin whitening and scar removing effects of the product are evaluated by taking an average value. The test effect is shown in the following table 1, and meanwhile, a test effect curve chart is given, which is shown in the attached figure 1.

Table 1 example 1 scar-removing effect recording table of whitening and whitening soothing cream

As can be seen from table 1 and fig. 1 above, continuous trial of the whitening and scar-removing cream provided in example 1 for 28 days can reduce the melanin content of the skin at the scar, restore the healthy and normal skin color of the skin, and has obvious effects on removing scar pigments and whitening the skin.

Example 2

The multiple-protection isolation essence comprises the following components in percentage by weight:

the main components are as follows:

auxiliary materials:

the preparation method of the multiple-protection isolation essence sequentially comprises the following steps:

Test example 2

1. Sun protection test:

the sun protection ability of the multiple protective barrier essence obtained in example 2 was tested by a sun protection factor tester (SPF-290S) to protect the skin against damage of ultraviolet rays, prevent sunburn and suntan, prevent photoaging of the skin, and prevent dry and dark skin caused by damage of ultraviolet rays. The results of the multiple protection barrier essence (in vitro) test were SPF 32, PA + + +.

2. Skin moisture barrier test:

the test principle is as follows: the moisturizing ability of the product was evaluated by testing the change in skin moisture content before and after the product was applied by volunteers using the human skin tester MAP 580.

The experimental method comprises the following steps: selecting 20 volunteers aged 25-35 years, and applying the same amount of the multiple protection isolation essence obtained in example 2 to the area fixed on the inner sides of the two arms, wherein the amount of the multiple protection isolation essence is 2mg/cm²The moisture content of the skin of the volunteers before and after use is tested by using a human skin tester, and the moisture retention performance of the product is evaluated by taking the average value. The test results are shown in the following table 2, and a test effect graph of moisture retention performance is shown in fig. 2.

Table 2 example 2 moisturizing effect recording table of multiple protection isolation essence

As can be seen from table 2 above and fig. 2, the multiple protective barrier essence provided by example 2 can increase the moisture of the skin, thereby increasing the barrier ability of the skin and keeping the skin in a healthy physiological state.

3. And (3) whitening test:

the test principle is as follows: the whitening efficacy of the product was evaluated by testing the amount of change in skin melanin before and after the use of the product by volunteers using a human skin tester MAP 580.

The experimental method comprises the following steps: selecting 20 volunteers aged 25-35 years in the area fixed at the inner sides of the two arms, and using the same amount of the multiple protection isolation essence provided in example 2, wherein the amount is 2mg/cm²The skin melanin content of volunteers on day 0, day 7, day 14, day 21, day 28 and blank skin melanin content were tested by using a human skin tester, and the whitening efficacy of the product was evaluated by averaging the skin melanin contents for 28 consecutive days in the morning, noon and evening. The test results are shown in table 3 below.

Table 3 whitening effect recording table of multiple protection isolation essence of example 2

Further processing was performed according to the data obtained in Table 3, and the skin melanin reduction amounts were calculated for the volunteers on 28 days, 7 days, 14 days, 21 days and 28 days of continuous use, to obtain the data in Table 4 below:

TABLE 4 Melanin reduction amount recording sheet

Further processing was performed according to the data obtained in Table 4, and the skin melanin reduction rates of the volunteers on 28 days, 7 days, 14 days, 21 days and 28 days were calculated to obtain the data of Table 5 below, and a corresponding graph was plotted, as shown in FIG. 3.

TABLE 5 Melanin reduction Rate Table

As can be seen from tables 3-5 and FIG. 3, the multiple protective isolation essence of example 2 was continuously tried for 28 days, the skin melanin reduction rate was 24.8%, and the skin color was brightened.

Example 3

The multi-effect whitening facial cleanser comprises the following components in percentage by weight:

the main components are as follows:

auxiliary materials:

the preparation method of the multi-effect whitening facial cleanser sequentially comprises the following steps:

Test example 3

And (3) whitening test:

the test principle is as follows: the whitening efficacy of the product was evaluated by testing the amount of melanin change in the skin before and after the product was applied by volunteers using the human skin tester MAP 580.

The experimental method comprises the following steps: 20 volunteers aged 25-35 were selected and tested before and after cleansing the face with the whitening cleanser of example 3 to test the change in melanin content of the facial skin and thereby evaluate the immediate whitening effect of the whitening cleanser, as shown in fig. 4.

As can be seen from figure 4, the skin melanin is obviously reduced after the multi-effect whitening facial cleanser is used, and the whitening effect is obvious.

Various other modifications and changes may be made by those skilled in the art based on the above-described technical solutions and concepts, and all such modifications and changes should fall within the scope of the claims of the present invention.

Claims

1. a whitening and scar removing skin care product, is characterized in that, comprises the following composition according to weight percentage:

3-o-ethylascorbic acid 0.01-5%; tranexamic acid 0.01-5%; carnosine 0.001-4%;

Schisandra chinensis extract 0.001-3%; Salicylic acid 0.001-1%; Allantoin 0.1-1%;

Retinyl Palmitate 0.001-1%; Anhydrous Ethanol 0.01-10%;

Vitis vinifera extract 0.001-2%; Excipients, balance;

The adjuvant is one or any combination of water, moisturizing agent, surfactant, emollient, sunscreen, thickening agent and preservative; the moisturizing agent includes polyhydric alcohol moisturizing agent and polysaccharide moisturizing agent ;

Described polyhydric alcohol moisturizing agent is a kind of in glycerol, diglycerol, butylene glycol, propylene glycol, dipropylene glycol, sorbitol, allantoin, polyethylene glycol-400 and PPG-10 methyl glucose ether or any combination;

The polysaccharide moisturizing agent is one or any combination of hyaluronic acid, sodium hyaluronate, pullulan, trehalose and sour bean seed extract;

Described surfactant is one or any combination in glyceryl stearate citrate, polysorbate-60 and fatty acid soap;

The emollient is one of jojoba oil, isononyl isononanoate, diethylhexyl carbonate, shea butter, vitamin E acetate, octylmethicone and bisabolol. species or any combination;

The sunscreen agent is ethylhexyl methoxycinnamate, ethylhexyl triazine ketone, bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylaminohydroxybenzoyl hexyl benzoate, butyl methoxy Dibenzoylmethane, disodium phenyldibenzimidazole tetrasulfonate, methylenebis-benzotriazolyl tetramethylbutylphenol, terephthalimethylenediscamphorsulfonic acid, zinc oxide , one or any combination of titanium dioxide, octyl salicylate, homosalate and octocrylene;

The thickener is one or any combination of carbomer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and ammonium acryloyl dimethyl taurate/VP copolymer;

The preservative includes one or any combination of benzoic acid, benzoate, phenoxyethanol and ethylhexylglycerol.

2. a preparation method of whitening and scar removing skin care product as claimed in claim 1, is characterized in that, when described adjuvant is water, comprises the following steps:

1) Preparation of phase A: at room temperature, place the formula amount of 3-o-ethyl ascorbic acid, allantoin, tranexamic acid, carnosine, Schisandra chinensis extract and Vitex chinensis extract in the first container, and then add the formula amount water, stir and dissolve to obtain phase A;

2) Preparation of phase B: at normal temperature, place the formula amount of retinyl palmitate and salicylic acid in the second container, then add the formula amount of absolute ethanol, stir and dissolve to obtain phase B;

3) Mixing: Adjust the temperature of phase A and phase B to 25-35℃, then mix and stir evenly, and that’s it.

3. whitening and scar removing skin care product according to claim 1, is characterized in that, described whitening and scar removing skin care product is a kind of complex face whitening and scarring facial cream, and it comprises the following components by mass percentage:

Main ingredients:

3-o-ethylascorbic acid 0.3-4%; tranexamic acid 0.3-4%;

Carnosine 0.002-3%; Schisandra chinensis extract 0.01-2%;

Salicylic acid 0.01-0.8%; Allantoin 0.2-0.8%;

Retinyl Palmitate 0.1-0.8%; Anhydrous Ethanol 0.015-8%;

Vitex Extract 0.1-1.5%;

Accessories:

Sodium Hyaluronate 0.001%; Glyceryl Stearate Citrate 2.5%;

Jojoba Oil 2.5%; Isononyl Isononanoate 3%;

Diethylhexyl Carbonate 3%; Shea Butter 1%;

Vitamin E acetate 0.1%; Octylmethicone 2%;

Bisabolol 0.1%; 1,3-Butanediol 6%;

Phenoxyethanol 0.3%; Ethylhexylglycerol 0.2%;

Ammonium acryloyldimethyltaurate/VP copolymer 0.65%;

Also includes flavor 0.1%;

water, balance.

4. a preparation method of whitening and scar removing skin care product as claimed in claim 3, is characterized in that, comprises the following steps:

1) Preparation of prefabricated solution A: in the first container, add vitamin E acetate, bisabolol and retinyl palmitate in formula amounts, stir and dissolve, and obtain prefabricated solution A;

2) Prepare prefabricated solution B: in the second container, add salicylic acid and absolute ethanol in the prescribed amount, stir and dissolve, and obtain prefabricated solution B;

3) Preparation of prefabricated solution C: divide the water in the formula into two parts, which are recorded as the first part of water and the second part of water; in the third container, add the formula of 3-o-ethyl ascorbic acid, tranexamic acid, carnosine , Schisandra chinensis extract and Vitex chinensis extract, and the first part of water, stirring and dissolving to obtain a prefabricated solution C;

4) Prepare the oil phase: In the fourth container, add the formula amount of jojoba oil, isononyl isononanoate, diethylhexyl carbonate, shea butter, octylmethicone and glycerin hard Fatty acid ester citrate, heated to 80-85°C, stirring and dissolving to obtain oil phase;

5) Prepare the water phase: in the fifth container, add allantoin, sodium hyaluronate and 1,3-butanediol in the formula amount, and the second part of water, heat to 80-85 ° C, stir and dissolve, and obtain water box;

6) Emulsification: add the oil phase to the water phase, stir homogeneously for 8-12min, and set the temperature to 50-55°C; then add the formula amount of ammonium acryloyldimethyltaurate/VP copolymer , Homogeneous stirring and thickening, when the temperature reaches 50-55 ℃, add the prefabricated solution A, homogenize and stir evenly; when the temperature is lowered to 40-45 ℃, add the prefabricated solution B and the prefabricated solution C, and the formula amount of Phenoxyethanol, ethylhexylglycerin and essence are mixed evenly, and when the temperature drops to 30-35°C, the complexion whitening and scarring facial cream is obtained.

5. whitening and scar removing skin care product according to claim 1, is characterized in that, described whitening and scar removing skin care product is a kind of multiple protection and isolation essence, and it comprises the following composition by mass percentage:

Main ingredients:

3-o-ethylascorbic acid 0.3-4%; tranexamic acid 0.3-4%;

Carnosine 0.002-3%; Schisandra chinensis extract 0.01-2%;

Salicylic acid 0.01-0.8%; Allantoin 0.2-0.8%;

Retinyl Palmitate 0.1-0.8%; Anhydrous Ethanol 0.015-8%;

Vitex Extract 0.1-1.5%;

Accessories:

Ethylhexyl Methoxycinnamate 7.5%; Ethylhexyl Triazinone 1%;

Polysorbate-60 1%; Vitamin E Acetate 0.1%;

Glycerin 2.5%;

1,3-Butanediol 4%; Phenoxyethanol 0.2%;

Ethylhexylglycerin 0.3%;

Sodium Hyaluronate 0.002%;

Bis-ethylhexyloxyphenol methoxyphenyl triazine 2.5%;

Diethylaminohydroxybenzoylhexylbenzoate 2.5%;

Acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer 0.2%;

Ammonium acryloyldimethyltaurate/VP copolymer 0.25%;

Also includes Fragrance 0.1%; Arginine 0.2%;

water, balance.

6. a preparation method of whitening and scar removing skin care product as claimed in claim 5, is characterized in that, comprises the following steps:

1) Preparing prefabricated solution A: In the first container, add vitamin E acetate and retinyl palmitate in formula amounts, stir and dissolve, and obtain prefabricated solution A;

3) Preparation of prefabricated liquid C: divide the amount of water in the formula into three parts, which are recorded as the first part of water, the second part of water and the third part of water; in the third container, add the formula amount of 3-o-ethyl ascorbic acid. , tranexamic acid, carnosine, Schisandra chinensis extract and Vitex chinensis extract, as well as the first part of water, stir and dissolve to obtain prefabricated solution C;

4) Preparation of prefabricated solution D: in the fourth container, add the formula amount of arginine and the second part of water, stir and dissolve, and obtain prefabricated solution D;

5) Preparation of oil phase: in the fifth container, add the formula amounts of ethylhexyl methoxycinnamate, ethylhexyl triazinone, bis-ethylhexyloxyphenol methoxyphenyl triazine, and diethylamino Hexyl hydroxybenzoyl benzoate and polysorbate-60, heated to 80-85°C, stirred and dissolved to obtain an oil phase;

6) Preparation of water phase: In the sixth container, add allantoin, sodium hyaluronate, 1, 3-butanediol and glycerol in the formula amount, and the third part of water, heat to 80-85 ℃, stir to dissolve, Add the formula amount of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, disperse and dissolve, and obtain the water phase;

7) Emulsification: add the oil phase to the water phase, stir homogeneously for 8-12min, and set the temperature to 50-55°C; then add the formula amount of ammonium acryloyldimethyltaurate/VP copolymer, Homogeneous stirring and thickening; when the temperature reaches 50-55°C, add the prefabricated solution A and the prefabricated solution D, and stir evenly; when the temperature is lowered to 40-45°C, add the prefabricated solution B and the prefabricated solution C, and The formula amounts of phenoxyethanol, ethylhexylglycerin and essence are stirred evenly, and when the temperature drops to 30-35° C., the multi-protection isolation essence is obtained.

7. whitening and scar removing skin care product according to claim 1, is characterized in that, described whitening and scar removing skin care product is a kind of whitening cleansing milk, and it comprises the following composition by mass percentage:

Main ingredients:

3-o-ethylascorbic acid 0.3-4%; tranexamic acid 0.3-4%;

Carnosine 0.002-3%; Schisandra chinensis extract 0.01-2%;

Salicylic acid 0.01-0.8%; Allantoin 0.2-0.8%;

Retinyl Palmitate 0.1-0.8%; Anhydrous Ethanol 0.015-8%;

Vitex Extract 0.1-1.5%;

Accessories:

Glycerol 20%; 1,3-Butanediol 10%;

Vitamin E acetate 0.1%;

Also includes EDTA-2Na 0.05%; Potassium Hydroxide 6.8%; Lauric Acid 8%; Myristic Acid 9%; Stearic Acid 6.2%; Palmitic Acid 11%;

water, balance.

8. a preparation method of whitening and scar removing skin care product as claimed in claim 7, is characterized in that, comprises the following steps:

3) Preparation of prefabricated solution C: divide the water of the formula into two parts, which are recorded as the first part of water and the second part of water; in the third container, add the formula of 3-o-ethyl ascorbic acid, tranexamic acid, carnosine , Schisandra chinensis extract and Vitex chinensis extract, and the first part of water, stir and dissolve to obtain prefabricated solution C;

4) Preparation of oil phase: in the fourth container, add lauric acid, myristic acid, stearic acid and palmitic acid in the formula amount, and heat and dissolve to obtain oil phase;

5) Preparation of water phase: In the fifth container, add allantoin, glycerin, 1,3-butanediol, EDTA-2Na and potassium hydroxide, and the second part of water in the formula amount, stir and dissolve to obtain the water phase ;

6) Saponification: add the oil phase to the water phase, homogenize until the soap mass is opened, stir and cool, when the temperature drops to 55-60°C, add the prefabricated solution A, prefabricated solution B and prefabricated solution C, stirring and dissolving, and when the temperature is lowered to 30-35° C., the whitening facial cleanser is obtained.