CN106841048B - Blood sugar concentration detection method and device based on polarised light magneto-optic effect - Google Patents
Blood sugar concentration detection method and device based on polarised light magneto-optic effect Download PDFInfo
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- G01N21/21—Polarisation-affecting properties
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
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Abstract
The present invention discloses a kind of blood sugar concentration detection method and device based on polarised light magneto-optic effect, this method is on the basis of magneto-optical deflection effect, the sample tube for containing blood glucose solution is placed in the magnetic cavity of magnetic confinement body formation, under the action of magnetic confinement body, the optically-active deflection angle for increasing blood glucose detects the light intensity after analyzer using light intensity meter；By rotating analyzer, light intensity when making in magnetic cavity with sample tube is consistent with light intensity when no sample test tube, the angle of analyzer deflection is measured by absolute type encoder, to realize the detection of blood sugar concentration in sample tube.Present invention detection speed is fast, and detection accuracy is high, reliable and stable, provides technical foundation for fields such as China's biomedicine, clinical medicine and brings huge economic benefit and social benefit.
Description
Technical field
The present invention relates to solution concentration detection technical field more particularly to a kind of blood glucose based on polarised light magneto-optic effect are dense
Spend detection method and device.
Background technique
With the invention of laser, light plays an important role on the stage of human world, especially in light and life section
It learns, the field that medicine combines, having many optical technologies is mankind's health service, such as optical medical diagnosis, optical image, people
The spectrum detection technique etc. of body ingredient.Currently, the conventional detection of blood sugar concentration is by fingerstick and venous blood collection etc., the party
Formula brings certain psychology and financial burden to patient, even results in superinfection, therefore blood glucose non-destructive testing technology is by pass
Note.Current most representative blood glucose optical non-destructive detection technology has Raman spectroscopy, polarimetry, near infrared spectroscopy etc., though
Certain effect is so achieved, but by the restriction for organizing the technical bottlenecks such as light scatters and disturbing factor is numerous.
Raman spectroscopy is a kind of method based on Raman scattering effect.Its principle is that the glucose in tissue is swashed
After light irradiation, changed by detection laser from the scattering optical frequency shift after measured matter outgoing, so that it may extrapolate blood sugar concentration.But
Due to the interference effect of other substances in tissue, the fluorescence background and Raman signal of protein molecule are close, to drawing
The detection of graceful signal is relatively difficult.Polarimetry is a kind of method for realizing blood sugar concentration detection using optical means.Its principle is
When polarizing light irradiation blood glucose solution, the rotation angle of polarised light changes and the glucose of its variation degree and detected solution
Concentration is positively correlated, and can extrapolate blood sugar concentration according to the variation that polarised light rotates angle.The deflection angle of polarimetry detection
It is smaller, interference it is more, measured deviation is larger, needs further studied.Near infrared spectroscopy is current most study in the world
Non-invasive measurement blood glucose method, have many advantages, such as quick, real-time, pollution-free, can directly detect human blood glucose concentration, be not necessarily to
Do specially treated.Near infrared light has good penetrability to body fluid and soft tissue, can carry glucose information abundant, be
Ideal detection spectrum segment.Its principle is that human local tissue after near infrared light, will form specific absorption light
Spectrum, the blood sugar concentration in tissue is calculated according to absorption spectrum.The theoretical basis of near infrared spectroscopy is that Lambert-Beer is fixed
Rule, it is indicated that the medium absorption degree and measured matter concentration that near infrared light passes through are proportional.In recent years, near infrared spectroscopy was ground
Study carefully more, but the practicability of these methods is poor, and there are a common difficult point, the background absorptions of tissue water to compare
Greatly, only specific subband can be used to detect.And that there are sensitivity is low, accuracy is low, repeats to mark near infrared spectroscopy
The problems such as determining, never very big breakthrough.
The non-invasive measurement of human blood glucose concentration is a system engineering, is related to clinical medicine, physics, stoichiometric chemistry, light
Various global questions such as spectroscopy, instrumental science, only system, comprehensively, in depth study various pieces, blood could be obtained
The breakthrough of sugared concentration non-invasive measurement.Studies have shown that blood glucose has optically-active characteristic, i.e., when a branch of linearly polarized light is mapped to containing glucose
Solution in when, transmitted light is also linearly polarized light, and there are an angles for polarization direction and the polarization direction of former incident light.It arrives
So far, since the optically-active deflection angle of blood glucose generation is small, it is difficult accurately to be measured, in accuracy, sensitivity and stabilization
Property aspect, the condition of clinical application has not yet been reached.
Summary of the invention
It is an object of the invention to come by a kind of blood sugar concentration detection method and device based on polarised light magneto-optic effect
Solve the problems, such as that background section above is mentioned.
To achieve this purpose, the present invention adopts the following technical scheme:
A kind of blood sugar concentration detection method based on polarised light magneto-optic effect comprising following steps:
A, helium neon laser generator and collimator and extender mirror are mounted on laser frame plate, and by laser frame plate and three-dimensional motion
Platform is connected, and the spatial position of helium neon laser generator is adjusted by three-dimensional movement platform；
B, magnetic confinement body is packed into magnetic confinement body support frame, magnetic confinement body support frame is mounted on guide rail；When initial, about by magnetic
Sample tube is not put into the magnetic cavity that beam body is formed；
C, the position between magnetic confinement body and helium neon laser generator is adjusted by guide rail, finds and polarised light is generated most preferably
The distance of effect；
D, the laser that helium neon laser generator projects can form polarised light by the polarizer, and the center line across magnetic cavity is final
It is irradiated on light intensity meter, light intensity at this time is write down by light intensity meter；
E, the sample tube for the standard blood glucose solution for containing various concentration is sequentially placed into magnetic cavity, rotation analyzer makes light
The light intensity of strong meter detection is identical as the light intensity detected when not being put into sample tube in magnetic cavity；
F, it by the angle of encoder measurement analyzer deflection, is acquired by data Collection & Processing System and handles encoder
The electric signal of output determines the relational expression between blood sugar concentration and analyzer deflection angle, completes analyzer deflection angle and blood glucose is dense
Relationship calibration between degree；
G, sample to be tested test tube is put into magnetic cavity, the analyzer deflection angle and the blood sugar concentration measured according to encoder
With the relational expression between analyzer deflection angle, the blood glucose solution concentration in sample to be tested test tube is determined.
Particularly, the magnetic confinement body is using any of permanent magnet or electromagnet form, wherein according to the permanent magnetism bodily form
Formula then becomes several pairs of N-S permanent magnets from a pair of of N-S permanent magnet by series connection, enhances magnetic field.
Particularly, the encoder uses absolute type encoder.
Particularly, the center line of the helium neon laser generator and collimator and extender mirror is coaxial.
Particularly, the sample tube and magnetic cavity being put into the magnetic cavity are coaxial.
The invention also discloses a kind of blood sugar concentration detection devices based on polarised light magneto-optic effect comprising laser occurs
Device, the polarizer, field generator for magnetic, Calibrator and data Collection & Processing System；The generating device of laser includes
Three-dimensional movement platform, laser frame plate, helium neon laser generator, collimator and extender mirror；The field generator for magnetic include guide rail, magnetic about
Beam body support frame, magnetic confinement body；The Calibrator includes analyzer, encoder, light intensity meter；Wherein, the He-Ne Lasers occurs
Device and collimator and extender mirror are mounted on laser frame plate, and the laser frame plate and three-dimensional movement platform are connected, and pass through three maintenance and operation
The spatial position of moving platform adjusting helium neon laser generator；The magnetic confinement body is mounted in magnetic confinement body support frame, by magnetic confinement
The magnetic cavity that body is formed, magnetic cavity are put into for sample tube；The magnetic confinement body support frame is mounted on guide rail；The analyzer and coding
Device is connected, and is beaten on light intensity meter by the polarised light of analyzer；The encoder connects data Collection & Processing System.
Particularly, the magnetic confinement body is using any of permanent magnet or electromagnet form, wherein according to the permanent magnetism bodily form
Formula then becomes several pairs of N-S permanent magnets by connecting from a pair of of N-S permanent magnet.
Particularly, the encoder connected with the analyzer is hollow, and polarised light passes through encoder and beats on light intensity meter；
The encoder uses absolute type encoder.
Particularly, the center line of the helium neon laser generator and collimator and extender mirror is coaxial.
Particularly, the sample tube and magnetic cavity being put into the magnetic cavity are coaxial.
It is proposed by the present invention based on the blood sugar concentration detection method and device of polarised light magneto-optic effect in magneto-optical deflection effect
On the basis of, the sample tube for containing blood glucose solution is placed in the magnetic cavity of magnetic confinement body formation, under the action of magnetic confinement body, is increased
The optically-active deflection angle of big blood glucose detects the light intensity after analyzer using light intensity meter；By rotating analyzer, make to have in magnetic cavity
Light intensity when sample tube is consistent with light intensity when no sample test tube, measures analyzer deflection by absolute type encoder
Angle, to realize the detection of blood sugar concentration in sample tube.Present invention detection speed is fast, and detection accuracy is high, reliable and stable, is
The fields such as China's biomedicine, clinical medicine provide technical foundation and bring huge economic benefit and social benefit.
Detailed description of the invention
Fig. 1 is the blood sugar concentration detection method flow chart provided by the invention based on polarised light magneto-optic effect；
Fig. 2 is the blood sugar concentration structure diagram of detection device provided by the invention based on polarised light magneto-optic effect.
Specific embodiment
To facilitate the understanding of the present invention, a more comprehensive description of the invention is given in the following sections with reference to the relevant attached drawings.In attached drawing
Give presently preferred embodiments of the present invention.But the invention can be realized in many different forms, however it is not limited to this paper institute
The embodiment of description.On the contrary, purpose of providing these embodiments is makes to the more thorough of the disclosure understanding
Comprehensively.It should be noted that be referred to as " being fixed on " another element when element, it can directly on the other element or
There may also be elements placed in the middle.When an element is considered as " connection " another element, it can be directly to separately
One element may be simultaneously present centering elements.Unless otherwise defined, all technologies used herein and section are academic
Language has the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.Herein in the description of the invention
Used term, which is only for the purpose of describing specific embodiments, is not intended to limit the present invention.It is used herein
Term " and/or " it include any and all combinations of one or more related listed items.
It please refers to shown in Fig. 1, Fig. 1 is the blood sugar concentration detection method stream provided by the invention based on polarised light magneto-optic effect
Cheng Tu.
Blood sugar concentration detection method in the present embodiment based on polarised light magneto-optic effect specifically comprises the following steps:
A, helium neon laser generator and collimator and extender mirror are mounted on laser frame plate, and by laser frame plate and three-dimensional motion
Platform is connected, and the spatial position of helium neon laser generator is adjusted by three-dimensional movement platform.In actual operation, the He-Ne swashs
The center line of optical generator and collimator and extender mirror should be coaxial as far as possible, adjusts the helium neon laser generator and standard in the present embodiment
The center line of straight beam expanding lens is coaxial.
B, magnetic confinement body is packed into magnetic confinement body support frame, magnetic confinement body support frame is mounted on guide rail；When initial, about by magnetic
Sample tube is not put into the magnetic cavity that beam body is formed.In order to guarantee the accuracy of adjustment, the guide rail is selected in the present embodiment
Precise guide rail, can be according to the precise guide rails of the different selection corresponding specifications of Adjustment precision when concrete application.The magnetic confinement body is adopted
It is any with permanent magnet or electromagnet form, wherein according to permanent magnet form, then by series connection by a pair of of N-S permanent magnet
Become several pairs of N-S permanent magnets, enhances magnetic field.
C, the position between magnetic confinement body and helium neon laser generator is adjusted by guide rail, finds and polarised light is generated most preferably
The distance of effect.
D, the laser that helium neon laser generator projects can form polarised light by the polarizer, and the center line across magnetic cavity is final
It is irradiated on light intensity meter, light intensity at this time is write down by light intensity meter.
The collimated beam expanding lens of laser that helium neon laser generator projects is by forming polarised light after the polarizer.When in magnetic cavity
When no sample test tube, polarised light is under the magnetic fields that magnetic confinement body generates, it may occur that small angle deflection, by after analyzer by
Light intensity meter writes down light intensity at this time.
E, the sample tube for the standard blood glucose solution for containing various concentration is sequentially placed into magnetic cavity, rotation analyzer makes light
The light intensity of strong meter detection is identical as the light intensity detected when not being put into sample tube in magnetic cavity.Need to illustrate when, the magnetic cavity
The sample tube being inside put into and magnetic cavity are coaxial.
When there is sample tube in magnetic cavity, polarised light is not only affected by magnetic fields, and light intensity can be molten by blood glucose in sample tube
Liquid influence, by after analyzer when beam intensity ratio no sample test tube it is small.The light intensity that light intensity meter can be made to detect by rotating analyzer
With in magnetic cavity when no sample test tube it is identical.
F, it by the angle of encoder measurement analyzer deflection, is acquired by data Collection & Processing System and handles encoder
The electric signal of output determines the relational expression between blood sugar concentration and analyzer deflection angle, completes analyzer deflection angle and blood glucose is dense
Relationship calibration between degree.The encoder uses absolute type encoder in the present embodiment.
G, sample to be tested test tube is put into magnetic cavity, the analyzer deflection angle and the blood sugar concentration measured according to encoder
With the relational expression between analyzer deflection angle, the blood glucose solution concentration in sample to be tested test tube is determined.
As shown in Fig. 2, Fig. 2 is the blood sugar concentration structure of the detecting device provided by the invention based on polarised light magneto-optic effect
Figure.
Blood sugar concentration detection device in the present embodiment based on polarised light magneto-optic effect specifically includes generating device of laser, rises
Inclined device 105, field generator for magnetic, Calibrator and data Collection & Processing System 113；The generating device of laser includes three
Maintenance and operation moving platform 101, laser frame plate 102, helium neon laser generator 103, collimator and extender mirror 104；The field generator for magnetic packet
Include guide rail (not shown), magnetic confinement body support frame 106, magnetic confinement body 109；The Calibrator includes analyzer 110, coding
Device 112, light intensity meter 111；The data Collection & Processing System 113 includes data collecting card, industrial personal computer, software processing module.
Wherein, the helium neon laser generator 103 and collimator and extender mirror 104 are mounted on laser frame plate 102, the laser frame plate 102
It is connected with three-dimensional movement platform 101, the spatial position of helium neon laser generator 103 is adjusted by the three-dimensional movement platform 101；
The magnetic confinement body 109 is mounted in magnetic confinement body support frame 106, and the magnetic cavity 107 formed by magnetic confinement body 109, magnetic cavity 107 is for sample
Product test tube 108 is put into；The magnetic confinement body support frame 106 is mounted on guide rail；The analyzer 110 is connected with encoder 112, leads to
The polarised light for crossing analyzer 110 is beaten on light intensity meter 111；The encoder 112 connects data Collection & Processing System 113.
The magnetic confinement body 109 is using any of permanent magnet or electromagnet form in the present embodiment, wherein according to
Permanent magnet form then becomes several pairs of N-S permanent magnets by connecting from a pair of of N-S permanent magnet, magnetic field can be enhanced in this way.At this
In embodiment, connected encoder 112 is hollow with the analyzer 110, and polarised light passes through encoder 112 and beats in light intensity meter
On 111.In the present embodiment, the encoder 112 uses absolute type encoder.In the present embodiment, the He-Ne Lasers hair
The center line of raw device 103 and collimator and extender mirror 104 is coaxial.The sample tube 108 and magnetic cavity 107 being put into the magnetic cavity 107 are same
Axis.The guide rail selects precise guide rail, and when application can be according to the precise guide rails of the different selection corresponding specifications of Adjustment precision.
Specifically, the three-dimensional movement platform 101 is used to adjust the spatial position of helium neon laser generator 103.It is described to swash
Light frame plate 102 makes the two coaxial line for installing helium neon laser generator 103 and collimator and extender mirror 104.The He-Ne Lasers hair
Raw device 103 is for emitting He-Ne low power laser；Diameter and diverging of the collimator and extender mirror 104 for changing laser beam
Angle；The polarizer 105 is for generating linearly polarized light；The guide rail for adjust magnetic confinement and helium neon laser generator 103 it
Between position, find to polarised light generate optimum efficiency distance；The magnetic confinement body support frame 106 is used for clamping magnetic confinement body
109, multipair permanent magnet can be accommodated with increasing magnetic field；The magnetic cavity 107 is permanent magnet or electromagnet by magnetic confinement body 109
The cylindrical magnetic field areas of formation, running parameter include 107 diameter of magnetic cavity, magnetic cavity 107 length, two parameters；The sample tube
Blood glucose solution is contained in 108, keeps coaxial with magnetic cavity 107 as far as possible；The mutual exclusion that the magnetic confinement body 109 is made of N-N or S-S
Magnetic confinement body 109, makes polarised light form deflecting effect under the influence of a magnetic field；The analyzer 110 is for examining certain light beam
Whether polarised light；For the light intensity meter 111 for detecting the light intensity after analyzer 110, this is the key that detection blood sugar concentration；
The absolute type encoder 112 measures the angle that analyzer 110 deflects, by angle information transfer to data Collection & Processing System
113.The data Collection & Processing System 113, which acquires, simultaneously handles the electric signal exported by encoder 112, according to blood sugar concentration with
Relational expression between 110 deflection angle of analyzer is determined the concentration of blood glucose solution to be measured by 110 deflection angle of analyzer.
It should be noted that the solution contained in the sample tube 108 is not limited to blood glucose solution, as long as its solution is dense
Influence and blood glucose solution of the degree to polarised light light intensity are same or similar, can detect its solution concentration through the invention.
The sample tube 108 for containing blood glucose solution is placed in by technical solution of the present invention on the basis of magneto-optical deflection effect
In the magnetic cavity 107 that magnetic confinement body 109 is formed, under the action of magnetic confinement body 109, increases the optically-active deflection angle of blood glucose, use light
Light intensity after strong 111 detection analyzer 110 of meter；By rotating analyzer 110, when making in magnetic cavity 107 with sample tube 108
Light intensity be consistent with light intensity when no sample test tube 108, pass through absolute type encoder measure analyzer 110 deflect angle
Degree, to realize the detection of blood sugar concentration in sample tube 108.Present invention detection speed is fast, and detection accuracy is high, reliable and stable,
Technical foundation is provided for fields such as China's biomedicine, clinical medicine and brings huge economic benefit and social benefit.
Note that the above is only a better embodiment of the present invention and the applied technical principle.It will be appreciated by those skilled in the art that
The invention is not limited to the specific embodiments described herein, be able to carry out for a person skilled in the art it is various it is apparent variation,
It readjusts and substitutes without departing from protection scope of the present invention.Therefore, although being carried out by above embodiments to the present invention
It is described in further detail, but the present invention is not limited to the above embodiments only, without departing from the inventive concept, also
It may include more other equivalent embodiments, and the scope of the invention is determined by the scope of the appended claims.
Those of ordinary skill in the art will appreciate that realizing all or part of the process in above-described embodiment method, being can be with
Relevant hardware is instructed to complete by computer program, the program can be stored in a computer-readable storage medium
In, the program is when being executed, it may include such as the process of the embodiment of above-mentioned each method.Wherein, the storage medium can be magnetic
Dish, CD, read-only memory (Read-Only Memory, ROM) or random access memory (Random Access
Memory, RAM) etc..
Claims (10)
1. a kind of blood sugar concentration detection method based on polarised light magneto-optic effect, which comprises the steps of:
A, helium neon laser generator and collimator and extender mirror are mounted on laser frame plate, and by laser frame plate and three-dimensional movement platform
It is connected, the spatial position of helium neon laser generator is adjusted by three-dimensional movement platform；
B, magnetic confinement body is packed into magnetic confinement body support frame, magnetic confinement body support frame is mounted on guide rail；When initial, by magnetic confinement body
Sample tube is not put into the magnetic cavity of formation；
C, the position between magnetic confinement body and helium neon laser generator is adjusted by guide rail, finds and optimum efficiency is generated to polarised light
Distance；
D, the laser that helium neon laser generator projects can form polarised light by the polarizer, and the center line across magnetic cavity finally irradiates
Onto light intensity meter, light intensity at this time is write down by light intensity meter；
E, the sample tube for the standard blood glucose solution for containing various concentration is sequentially placed into magnetic cavity, rotation analyzer makes light intensity meter
The light intensity of detection is identical as the light intensity detected when not being put into sample tube in magnetic cavity；
F, it by the angle of encoder measurement analyzer deflection, is acquired by data Collection & Processing System and handles encoder output
Electric signal, determine the relational expression between blood sugar concentration and analyzer deflection angle, complete analyzer deflection angle and blood sugar concentration it
Between relationship calibration；
G, sample to be tested test tube is put into magnetic cavity, the analyzer deflection angle and the blood sugar concentration measured according to encoder and inspection
Relational expression between inclined device deflection angle, determines the blood glucose solution concentration in sample to be tested test tube.
2. the blood sugar concentration detection method according to claim 1 based on polarised light magneto-optic effect, which is characterized in that described
Magnetic confinement body is any using permanent magnet or electromagnet form, wherein according to permanent magnet form, then by series connection by a pair
N-S permanent magnet becomes several pairs of N-S permanent magnets, enhances magnetic field.
3. the blood sugar concentration detection method according to claim 1 based on polarised light magneto-optic effect, which is characterized in that described
Encoder uses absolute type encoder.
4. the blood sugar concentration detection method according to claim 1 based on polarised light magneto-optic effect, which is characterized in that described
The center line of helium neon laser generator and collimator and extender mirror is coaxial.
5. according to claim 1 to, based on the blood sugar concentration detection method of polarised light magneto-optic effect, feature exists described in one of 4
In the sample tube being put into the magnetic cavity and magnetic cavity are coaxial.
6. a kind of blood sugar concentration detection device based on polarised light magneto-optic effect, which is characterized in that including generating device of laser, rise
Inclined device, field generator for magnetic, Calibrator and data Collection & Processing System；The generating device of laser includes three-dimensional motion
Platform, laser frame plate, helium neon laser generator, collimator and extender mirror；The field generator for magnetic includes guide rail, magnetic confinement body branch
Frame, magnetic confinement body；The Calibrator includes analyzer, encoder, light intensity meter；Wherein, the helium neon laser generator and standard
Straight beam expanding lens is mounted on laser frame plate, and the laser frame plate and three-dimensional movement platform are connected, and passes through the three-dimensional movement platform
Adjust the spatial position of helium neon laser generator；The magnetic confinement body is mounted in magnetic confinement body support frame, is formed by magnetic confinement body
Magnetic cavity, magnetic cavity is put into for sample tube；The magnetic confinement body support frame is mounted on guide rail；The analyzer and encoder are solid
Even, it is beaten on light intensity meter by the polarised light of analyzer；The encoder connects data Collection & Processing System.
7. the blood sugar concentration detection device according to claim 6 based on polarised light magneto-optic effect, which is characterized in that described
Magnetic confinement body is any using permanent magnet or electromagnet form, wherein according to permanent magnet form, then by series connection by a pair
N-S permanent magnet becomes several pairs of N-S permanent magnets.
8. the blood sugar concentration detection device according to claim 6 based on polarised light magneto-optic effect, which is characterized in that with institute
State the connected encoder of analyzer be it is hollow, polarised light passes through encoder and beats on light intensity meter；The encoder is using absolute
Formula encoder.
9. the blood sugar concentration detection device according to claim 6 based on polarised light magneto-optic effect, which is characterized in that described
The center line of helium neon laser generator and collimator and extender mirror is coaxial.
10. based on the blood sugar concentration detection device of polarised light magneto-optic effect, feature according to one of claim 6 to 9
It is, the sample tube being put into the magnetic cavity and magnetic cavity are coaxial.
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