CN106821588A - An analgesic cryospray with a specific aerosol valve and actuator - Google Patents

Abstract

The invention discloses an analgesic frozen spray with a specific aerosol valve and an actuator, which comprises the following components in percentage by mass: 80% -95% of refrigerant, 3% -19.5% of pressurizing agent and 0.5% -2% of wetting agent. Weighing 0.5-2% of wetting agent by mass percent, filling the wetting agent into an aerosol can through a micro precision metering device, then installing a specific aerosol valve, and sealing the aerosol can; filling 80-95% of refrigerant into the aerosol tank according to the mass percentage, filling 3-19.5% of pressurizing agent into the aerosol tank, and then adding a specific actuator to obtain the aerosol. The spray of the invention has short cooling maintaining time, can avoid adverse reactions such as cold burn and the like, and can adjust the instant refrigeration temperature which is between-10 ℃ and-30 ℃. The product of the invention can be quickly atomized when being sprayed out, and can be sprayed out in a beam-shaped fog with a certain impact feeling, thereby enhancing the analgesic effect.

Description

An analgesic cryospray with a specific aerosol valve and actuator

technical field

The invention belongs to the field of aerosol technology, and in particular relates to an analgesic freezing spray with a specific aerosol valve and actuator, and also relates to a preparation method of the aerosol product.

Background technique

The aerosol product refers to a product in which the composition is sealed and contained in an aerosol can equipped with an aerosol valve at the injection port, and is sprayed out in a predetermined form under the pressure of the propellant. The main spray forms of aerosol products are mist, foam, powder or micelles, among which mist is the more common spray form.

The liquefied gas in the aerosol can is instantly sprayed out in the form of mist. Due to the heat absorption effect of gasification, it absorbs a large amount of surrounding heat and quickly cools down, so as to achieve the effects of cold therapy such as pain relief, anti-swelling, and reduction of secondary damage.

Cryospray has good analgesic and hemostatic effects, which are unanimously recognized by domestic and foreign literature, and confirmed by a series of strict experiments and clinical observations. There are many kinds of frozen spray products in the prior art. These aerosol products utilize the heat-absorbing and cooling effect of liquefied gas vaporization to produce a certain freezing effect. However, the instantaneous cooling temperature cannot be controlled between -10°C and -30°C by adjusting the composition of the refrigerant. Accompanied by a certain sense of shock to enhance the analgesic effect. Therefore, existing cryospray product has bigger limitation, influences analgesic effect.

Contents of the invention

Aiming at the problems existing in the prior art, the object of the present invention is to provide an analgesic frozen spray product with a specific aerosol valve and actuator and its preparation method, which solves the problem of difficulty in controlling the frozen spray products of the prior art. The problem of cold temperature, the inability to achieve rapid spraying in the form of beam mist accompanied by a certain sense of surprise, and the uncontrollable cooling maintenance time can easily cause adverse reactions such as cold burns.

In order to achieve the above object, the present invention adopts the following technical solutions:

An analgesic cryospray with a specific aerosol valve and actuator, including a specific aerosol valve and actuator, 2-4 holes with a diameter of Φ0.3mm-0.6mm are set on the valve stem of the aerosol valve And the symmetrical or misplaced flow holes also include an integrated structural actuator with a spray hole diameter of 0.4mm-1.0mm; the composition includes a refrigerant, a supercharging agent, and a wetting agent; the refrigerant is selected At least one of propane, dimethyl ether, n-butane, and isobutane, the mass content of which is 80-95% of the composition; the booster is selected from HFC-134a, HFO-1234ze, nitrogen, carbon dioxide At least one of them, whose mass content is 3-19.5% of the composition; said wetting agent is selected from at least one of propylene glycol, ethanol, glycerin, Tween, and its mass content is 0.5-2% of the composition .

The analgesic frozen spray product with a specific aerosol valve and actuator can be rapidly atomized when sprayed, sprayed in the form of beam mist and accompanied by a certain sense of shock, so as to significantly enhance the analgesic effect. The aerosol valve controls the rate and impact of the aerosol product release. The key factors are the number, size and arrangement of flow holes on the valve stem. Within a certain range, as the number of flow holes increases or the hole diameter increases, the release rate increases and the impact force is stronger. Symmetrical or misaligned settings are more conducive to accelerating the flow rate than unilateral settings, and play a role of vector superposition. The actuator controls the spray shape and atomization effect of the spray product. The key factor is the aperture diameter of the spray hole of the micro-atomizer. Within a certain range, the smaller the spray hole diameter, the smaller the spray angle and the finer the mist particles ; When the pressure in the aerosol tank is high and the release rate is high, the one-piece structure actuator should be selected instead of the embedded two-piece structure to prevent the micro-atomizer from being sprayed off.

The analgesic freezing spray product with a specific aerosol valve and actuator has an instantaneous cooling temperature of -10°C to -30°C, and the instantaneous cooling temperature can be determined by the composition of the refrigerant, that is, propane , dimethyl ether, n-butane, and isobutane and mix them in proportion. The instant refrigeration temperature can be in any temperature range within the range of -10°C to -30°C, and the deviation is not greater than 5°C .

The analgesic frozen spray product with a specific aerosol valve and actuator is designed to keep the cooling time short when it is sprayed onto human skin, and the temperature of the sprayed part after 15 minutes is close to the level before spraying, so as to avoid Adverse reactions such as cold burns, the mass content of the wetting agent in the composition is 0.5-2% of the composition, and the wetting agent is selected from at least one of propylene glycol, ethanol, glycerin, and Tween.

For the analgesic frozen spray product with a specific aerosol valve and actuator, in order to ensure that the injection pressure of the product is constant throughout the use cycle and maintain the atomization effect, the mass content of the booster in the composition is 3-19.5%, at least one selected from HFC-134a, HFO-1234ze, nitrogen, and carbon dioxide.

The analgesic frozen spray product with a specific aerosol valve and actuator, in order to make its spray have a mint aroma and cool feeling, the composition can also include an auxiliary agent, the mass content of the auxiliary agent is 0.01-0.05% of the composition, the auxiliary agent is selected from one of levomenthol or racemic menthol.

For realizing the preparation method that the present invention adopts, comprise the following steps:

(1) Weighing 0.5-2% wetting agent according to mass percentage;

(2) The wetting agent obtained in step (1) is measured by a micro-precision metering device according to a predetermined value, poured into the aerosol can, and then installed with a specific aerosol valve, and sealed;

(3) Fill the aerosol tank with 80-95% refrigerant according to the predetermined composition according to the mass percentage, then fill the aerosol tank with 3-19.5% booster according to the mass percentage, and then add the specific The actuator is there.

The preparation method of the present invention adjusts the instant refrigeration temperature by changing the composition of the refrigerant, that is, selects one or more of propane, dimethyl ether, n-butane, and isobutane and mixes them in proportion. The temperature can be in any temperature range within the range of -10°C to -30°C, and the deviation is not more than 5°C.

The components, content ranges and functions of each component in the composition are illustrated below in a tabular form.

The contents in the table are all mass percentages relative to the mass of the composition.

Among them, propane/dimethyl ether/n-butane/isobutane/is used as refrigerant, HFC-134a/HFO-1234ze/nitrogen/carbon dioxide is used as supercharging agent, and propylene glycol/ethanol/glycerin/Tween is used as wetting agent.

Tween in the table refers to polysorbate, a nonionic surfactant.

HFC-134a in the table refers to 1,1,1,2-tetrafluoroethane.

HFO-1234ze in the table refers to trans-1,3,3,3-tetrafluoropropene.

Adding the above-mentioned additives as optional components does not affect the basic performance of the product; adding L-menthol has a mint aroma and has a cooling effect, and adding racemic menthol has a cooling effect.

Beneficial effects of the present invention:

Compared with the prior art, the present invention combines the refrigerant and the wetting agent in an aerosol can, and presses the actuator on the aerosol valve so that the composition is sprayed out from the aerosol can, quickly The moment of gasification produces a freezing effect due to a large amount of heat absorption, and the instantaneous cooling temperature is between -10°C and -30°C, and the instantaneous cooling temperature can be determined by the composition of the refrigerant; the composition contains a wetting agent, so that the spray can be sprayed onto the human body The cooling time of the skin is short, and the temperature of the sprayed area after 15 minutes is close to the level before spraying, avoiding adverse reactions such as cold burns; the valve stem of the aerosol valve is symmetrical or misplaced and set 2-4 holes with a diameter of 0.3mm-0.6mm The flow hole, the integrated structure of the actuator and the diameter of the outlet of the micro-atomizer are Φ0.4mm-1.0mm, so that it can be atomized quickly when spraying, and it can be sprayed in a bundle of mist accompanied by a certain sense of shock to significantly enhance analgesia As a result, under the synergistic effect of the supercharger, the injection pressure of the product is kept constant throughout the service cycle and the atomization effect is maintained, preventing the micro-atomizer from spraying out during the injection process, thereby expanding the application field of the product.

The pressurizer in the spray composition of the present invention uses an inert gas, which has many advantages. One is to ensure that the spray pressure of the product is constant throughout the service life and to maintain the atomization effect; The third is to reduce the flammability of the ejected material and improve the safety of the product.

Description of drawings

Fig. 1 is a schematic structural view of the aerosol valve of the present invention;

Fig. 2 is a schematic structural view of the valve stem of the aerosol valve of the present invention;

Fig. 3 is a structural schematic diagram of the actuator of the present invention.

Among the above-mentioned accompanying drawings: 1-valve rod; 2-flow hole; 3-micro atomizer; 4-ejection hole.

detailed description

In order to better explain the present invention, it is further described in conjunction with the following specific examples, but the present invention is not limited to the specific examples.

Example 1

An analgesic frozen spray composition, comprising the following components by mass percentage:

Spray component name Content (%, w/w) propane 50 Isobutane 44.5 carbon dioxide 5 Propylene Glycol 0.5

Aerosol valve and actuator: The valve stem of the aerosol valve has 4 flow holes with a diameter of Φ0.6mm; the diameter of the spray hole of the micro-atomizer of the actuator is Φ0.6mm.

Example 2

An analgesic frozen spray composition, comprising the following components by mass percentage:

Spray component name Content (%, w/w) propane 40 Isobutane 44.6 HFC-134a 15 ethanol 0.4

Aerosol valve and actuator: The valve stem of the aerosol valve has 2 flow holes with a diameter of Φ0.8mm; the diameter of the spray hole of the micro-atomizer of the actuator is Φ0.8mm.

Example 3

An analgesic frozen spray composition, comprising the following components by mass percentage:

Spray component name Content (%, w/w) n-butane 80.5 HFO-1234ze 15 Nitrogen 4 glycerin 0.48 Levomenthol 0.02

Aerosol valve and actuator: The valve stem of the aerosol valve has 4 flow holes with a diameter of Φ0.8mm; the diameter of the ejection hole of the micro-atomizer of the actuator is Φ1.0mm.

Claims (9)

1. the analgesia cryospray agent with specific aerosol valve with actuator, it is characterised in that the valve rod of the specific aerosol valve Multiple symmetrical or Heterogeneous Permutation metering orifices are set；The specific actuator is integrated actuator；The analgesia freezing gas Mist agent composition includes refrigerant, hypertensor, wetting agent；The mass content of the refrigerant is the 80-95% of composition, described The mass content of hypertensor is the 3-19.5% of composition, and the mass content of the wetting agent is the 0.5-2% of composition.

2. the analgesia cryospray agent with specific aerosol valve Yu actuator according to claim 1, it is characterised in that institute State on the valve rod of specific aerosol valve 2-4 metering orifice of setting, metering orifice symmetrically or is shifted to install, aperture Φ 0.3mm-0.6mm；Institute Specific actuator is stated for unitary actuator, actuator realizes that machinery is smashed with micro- atomizer integrated structure（Without filling in addition Embedding micro- atomizer）, micro- atomizer squit hole aperture is 0.4mm-1.0mm.

3. the analgesia cryospray agent with specific aerosol valve Yu actuator according to claim 2, it is characterised in that spray When going out can quick break, gone out with pencil spray painting and with certain assault sense, strengthen analgesic effect.

4. the analgesia cryospray agent with specific aerosol valve Yu actuator according to claim 1, it is characterised in that institute State at least one during refrigerant is selected from propane, dimethyl ether, normal butane, iso-butane；The hypertensor is selected from HFC-134a, HFO- At least one in 1234ze, nitrogen, carbon dioxide；The wetting agent be selected from propane diols, ethanol, glycerine, tween at least It is a kind of.

5. the analgesia cryospray agent with specific aerosol valve Yu actuator according to claim 1, it is characterised in that logical The composition of adjustment refrigerant is crossed, moment cold temperatures can be made to be adjusted between -10 DEG C~-30 DEG C.

6. the analgesia cryospray agent with specific aerosol valve Yu actuator according to claim 1, it is characterised in that logical Cross the composition of adjustment hypertensor, it can be ensured that spray is constant in the injection pressure of whole usage cycles and keeps atomizing effect, and The phenomenon that ejiction opening is blocked by icing when being prevented effectively from continuous injection.

7. the analgesia cryospray agent with specific aerosol valve and actuator according to claim 2,4 or 5, its feature exists In, when being ejected into human body skin, cooling is held time shorter, and the local temperature of spray is applied after 15 minutes close to the level applied before spray, The cold adverse reaction such as burn can be avoided.

8. the preparation method of the analgesia cryospray agent with specific aerosol valve and actuator described in, it is characterised in that including Following steps：

（1）The wetting agent of 0.5-2% is weighed according to mass percent；

（2）By step（1）The wetting agent of gained, is measured by micro-precision metering device by predetermined value, is poured into inhalator jar, then Specific aerosol valve is filled, is sealed；

（3）According to mass percent to the refrigerant that 80-95% is filled in inhalator jar, according still further to mass percent in inhalator jar The hypertensor of 3-19.5% is filled, the specific actuator is then installed additional and is obtained final product.

9. the preparation method of the analgesia cryospray agent with specific aerosol valve and actuator according to claim 8, its It is characterised by, by changing minority refrigerant component, can adjust moment cold temperatures, scope is between -10 DEG C~-30 DEG C.