CN106729214A - Medicine and preparation method thereof for treating gout - Google Patents
Medicine and preparation method thereof for treating gout Download PDFInfo
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- CN106729214A CN106729214A CN201710037263.3A CN201710037263A CN106729214A CN 106729214 A CN106729214 A CN 106729214A CN 201710037263 A CN201710037263 A CN 201710037263A CN 106729214 A CN106729214 A CN 106729214A
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Abstract
The invention discloses a kind of medicine for treating gout and preparation method thereof, the medicine for treating gout is counted by weight, is the medicament being made up of following raw materials：20 40 parts of Radix Codonopsis, 10 30 parts of smilax, 10 30 parts of the root of Chinese clematis, 10 30 parts of the Radix Astragali, 5 15 parts of pseudo-ginseng, 5 15 parts of the bark of ash, 5 15 parts of arisaema cum bile, fries 5 15 parts of rhizoma atractylodis, 5 15 parts of first pearl, 5 15 parts of black-snake, windproof 5 15 parts, 5 15 parts of peach kernel, 5 15 parts of safflower, 5 15 parts of cassia twig, 5 15 parts of Ligusticum wallichii, 5 15 parts of Divine Comedy.The present invention cures mainly function：Clearing heat and promoting diuresis, eliminating the phlegm have one's ideas straightened out, it is promoting blood circulation and removing obstruction in channels, replenish qi to invigorate the spleen.The present invention adapts to symptom：Redness and swelling of joints heat pain, gout for mutually fought for damp and hot turbid poison, the wet bet of spleen, fever and chills, causing etc..
Description
Technical field
The present invention relates to a kind of medicine for treating gout and preparation method thereof.
Background technology
Gout is the crystal caused by disorders of purine metabolism produces excessive monosodium urate salt MSU to accumulate precipitation in vivo
Correlation arthropathy, it is directly related with the hyperuricemia caused by purine metabolic disturbance and underexcretion.
Clinically with hyperuricemia as principal character, acute gouty arthritis is the most common onset symptoms of gout,
Also be the most basic type of gout, mainly include acute attack arthritis, tophus formation, tophaceous chornic arthritis,
Urate nephropathy and uric acid lithangiuria, severe one may occur in which joint deformity and renal insufficiency.Gout is often with Central obesity, height
Pionemia, hypertension, diabetes and cardiovascular disease etc. are showed.This disease symptoms pain, high recurrence rate.
Gout is the dysbolism disease for spreading all over the world.In recent years, as living standards of the people are improved, dietary structure becomes
Change, the incidence of disease of urarthritis be in ascendant trend year by year, and southern ascendant trend becomes apparent from than the north, and person in middle and old age are male
The property incidence of disease is higher.
Motherland's medicine and pharmacology have accumulated rich experience in terms of gout treatment, and the treatment of the stronger adjusting body of the traditional Chinese medical science, sample is simultaneous
Control and put prevention first, Chinese medicine is few and famous with adverse reaction.Therefore, it is highly significant and necessary to develop and treat the sick Chinese medicine preparation
's.
The content of the invention
A kind of medicine for treating gout, counts by weight, including the medicament that following raw materials are made：Radix Codonopsis 20-40
Part, smilax 10-30 parts, root of Chinese clematis 10-30 parts, Radix Astragali 10-30 parts, pseudo-ginseng 5-15 parts, bark of ash 5-15 parts, fry rhizoma atractylodis 5-15
Part, 5-15 parts of first pearl is black-snake 5-15 parts, windproof 5-15 parts, peach kernel 5-15 parts, safflower 5-15 parts, cassia twig 5-15 parts, Ligusticum wallichii 5-
15 parts.
A kind of medicine for treating gout, counts by weight, including the medicament that following raw materials are made：Radix Codonopsis 20-40
Part, smilax 10-30 parts, root of Chinese clematis 10-30 parts, Radix Astragali 10-30 parts, pseudo-ginseng 5-15 parts, bark of ash 5-15 parts, fry rhizoma atractylodis 5-15
Part, 5-15 parts of first pearl is black-snake 5-15 parts, windproof 5-15 parts, peach kernel 5-15 parts, safflower 5-15 parts, cassia twig 5-15 parts, Ligusticum wallichii 5-
15 parts, Divine Comedy 5-15 parts.
A kind of medicine for treating gout, counts by weight, including the medicament that following raw materials are made：Radix Codonopsis 20-40
Part, smilax 10-30 parts, root of Chinese clematis 10-30 parts, Radix Astragali 10-30 parts, pseudo-ginseng 5-15 parts, bark of ash 5-15 parts, arisaema cum bile 5-15
Part, 5-15 parts of rhizoma atractylodis are fried, 5-15 parts of first pearl is black-snake 5-15 parts, windproof 5-15 parts, peach kernel 5-15 parts, safflower 5-15 parts, cassia twig
5-15 parts, Ligusticum wallichii 5-15 parts.
A kind of medicine for treating gout, counts by weight, is the medicament being made up of following raw materials：Radix Codonopsis 20-40
Part, smilax 10-30 parts, root of Chinese clematis 10-30 parts, Radix Astragali 10-30 parts, pseudo-ginseng 5-15 parts, bark of ash 5-15 parts, arisaema cum bile 5-15
Part, 5-15 parts of rhizoma atractylodis are fried, 5-15 parts of first pearl is black-snake 5-15 parts, windproof 5-15 parts, peach kernel 5-15 parts, safflower 5-15 parts, cassia twig
5-15 parts, Ligusticum wallichii 5-15 parts, Divine Comedy 5-15 parts.
Described medicament is formulation described in any pharmacy.
Described medicament is powder, the water-bindered pill, block agent, honeyed bolus or capsule.
A kind of preparation method for treating the medicine of gout, comprises the following steps：By described raw material drying, it is crushed to
100-200 mesh fine powders, sieving；Mix in a ratio, be made medicament.
Described medicament can be water pill, through drying in the shade or medicinal powder being directly loadable into capsule, honey can also be added to be made
Honeyed bolus.
A kind of preparation method for treating the medicine of gout, the medicine is the water-bindered pill, is comprised the following steps：
S1 prepares each bulk drug according to the weight portion；
More than S2 ingredientss, plus concentration of volume percent is the ethanol solution extraction of 60-80%, the weight of ethanol solution
It is 8-12 times of the medicinal material gross weight, extracts 2-3 times, each 0.5-2 hours, ethanol extract reclaims ethanol, is concentrated into 80
DEG C when determine relative density for 1.20-1.30 medicinal extract, obtain extraction extractum A, the dregs of a decoction are standby；
The dregs of a decoction that S3 steps S2 is obtained, extracting in water, the weight of water is 5-15 times of medicinal material gross weight, extraction 2-3 times, often
Secondary 0.5-2 hours, it is the medicinal extract of 1.20-1.30 that aqueous extract determines relative density when being concentrated into 80 DEG C, must extract medicinal extract B；
S4 will extract extractum A and extract medicinal extract B and merge, and obtain and always extract medicinal extract, dry, and obtain dry extract；
S5 obtains final product the above-mentioned general pelletization of dry extract water, packing.
Present invention also offers another preparation method of the medicine for treating gout, the medicine is the water-bindered pill, bag
Include following steps：
Y1 weighs ingredients according to the weight portion, crushes respectively, mixing；
Y2 is that 65-95% ethanol is extracted with concentration of volume percent, obtains extract solution；
Extract solution is concentrated, dried, the general pelletization of water by Y3.
Extracting method is Microwave Extraction in the step Y2, and solid-liquid ratio is 1：(20-40).The Microwave Extraction is divided into three ranks
Section, first stage Extracting temperature is 45-55 DEG C, and extraction time is 5-15min, and microwave power is 650-750W, and second stage is carried
It is 85-95 DEG C to take temperature, and extraction time is 20-60min, and microwave power is 250-350W, and phase III Extracting temperature is 45-55
DEG C, extraction time is 5-15min, and microwave power is 650-750W.
The present invention for treating the medicine of gout, instructions of taking using oral, 2-3 times on the one, one time 5-10 grams, opened with temperature
Mixing in water for oral taking.
Radix Codonopsis, Classification system Codonopsis pilosula (Franch.) Nannf. has strengthen immunity, expansion blood
The effects such as pipe, step-down, improvement microcirculation, enhancing hematopoiesis function.
Smilax, it is sweet, light, it is mild-natured.There is removing toxic substances, dehumidify, the effect of easing joint movement, be mainly used in syphilis and mercury poisoning institute
The limbs contraction of cause, arthralgia and myalgia；Damp and hot stranguria with turbid discharge, under band, carbuncle swells, scrofula, mange.
The root of Chinese clematis, scientific name：Clematis chinensis Osbeck, the effect of stalk with wind-damp dispelling, degrading the channel, the bone that disappears.
The Radix Astragali, Classification system Astragalus membranaceus (Fisch.) Bunge., it has enhancing immunity of organism work(
Energy, liver protection, diuresis, anti-aging, resisting stress, step-down and wide antibacterial action.
Pseudo-ginseng, Chinese medicine name.Main product, in Yunnan Wenshan Prefecture, therefore named mountain of papers pseudo-ginseng, also known as literary state pseudo-ginseng, is Araliaceae three
The dry root and rhizome of seven Panax notoginseng (Burk.) F.H.Chen.Sweet, slight bitter, temperature.Return liver, stomach.The scattered stasis of blood is stopped
Blood, detumescence ding-tong.For spitting blood, spit blood, bleeding from five sense organs or subcutaneous tissue is had blood in stool, uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain, tumbling and swelling.
The bark of ash, Chinese medicine name.It is doing for Oleaceae plants fraxinus rhynchophylla Hance, Chinese ash, sharp leaf Chinese ash or place post Chinese ash
Dry branch skin or dry hide.It is bitter, puckery, it is cold in nature.Cure mainly：Heat-clearing and damp-drying drug, inducing astrigency stop dysentery, stop-band, improving eyesight.For heat toxin rush down dysentery, red white
Under band, red eye, swell pain, mesh life ocular.
Arisaema cum bile, be《Chinese Pharmacopoeia》Version one is recorded within 2010, carries out the bent class Chinese medicine of Chinese medicines quasi-word number management.Day processed
The fine powder of Southern Star processes from strand with ox, sheep or pig's bile, or is unprocessed Arisaema erubescens fine powder and ox, sheep or the fermented processing of pig's bile
Form.Bitter cold, micro-pungent, it is cool.Return lung, liver, the spleen channel.Clearing heat and eliminating phlegm, dispelling wind and relieving convulsion.
Rhizoma atractylodis are fried, also known as bran fries rhizoma atractylodis, pungent, hardship, temperature.Returns spleen, stomach, Liver Channel.It is drying damp and strengthening spleen, expelling wind and clearing away cold, improving eyesight.For
Abdominal fullness and distention, diarrhea, oedema, arthralgia pain due to rheumatism, anemofrigid cold, yctalopia.
First pearl, is the scale and shell of Manidae animal pangolin.Detumescence is burst carbuncle, searches that wind is active, and stimulate the menstrual flow lower breast.Control ulcer sore swells, wind
Cold-dampness numbness, amenorrhea, alactation is had blood in stool.Latin name：Squama Manitis original animal Manis pentadactyla
L.。
Zaocys dhumnade, is commonly called as black snake, zaocys dhumnades, is that Colubridae zaocys dhumnade belongs to the larger snake of the bodily form.Wind-dispelling, dredging collateral, only convulsion.With
In rheumatoid arthritis stubborn, numbness contracture, apoplexy facial paralysis, hemiplegia, tic spasm, lockjaw, leprosy mange, scrofula dislikes sore.
It is sweet, put down.Return liver warp.
It is windproof, taste is pungent, sweet, slightly warm in nature.Expel pathogenic wind from the body surface, win wet analgesic, only effect of convulsion.
Peach kernel, Chinese medicine name.It is rosaceous plant peach Prunus persica (L.) Batsch or mountain peach Prunus
The dry mature seed of davidiana (Carr.) Franch..With promoting blood circulation, relax bowel, relieving cough and asthma effect.With
In closed dysmenorrhea, lump in the abdomen lump in the abdomen lump in the abdomen, lung carbuncle acute appendicitis, injury from falling down, dry constipation of intestines, cough and asthma.
Safflower, Classification system：Carthamus tinctorius L., alias：Red blue flower, thorn safflower, composite family, safflower category
Plant.Invigorate blood circulation, blood stasis removing analgesic, contribute to controlling through closing, dysmenorrhoea, lochia, chest impediment and cardialgia, stasis of blood, chest side of body shouting pain,
Traumatic injury, sore swell and ache curative curative effect.Have promoting blood circulation and removing blood stasis, effect of dissipate wet effect going to swell.
Cassia twig, alias：Liu Gui, scientific name：Cinnamomum cassia Presl, are canella Chinese cassia tree Cinnamomum
The dry twig of cassia Presl.Cassia twig energy sweating expelling pathogenic factors from muscles and skin, warming meridians and promoting circulation of qi, helps yang transforming qi, eliminating cold to stop pain.Main exterior syndrome due to wind-cold；
Numbness and ache of cold dampness；Peripheral coldness；Closed dysmenorrhea；Abdominal mass lumps；The obstruction of qi in the chest；Palpitaition；Phlegm and retained fluid；Difficult urination.For anemofrigid cold, gastral cavity abdomen
Crymodynia, blood trembles with fear Amenorrhea, joint pain, phlegm and retained fluid, oedema, palpitaition, run quickly globefish.
Ligusticum wallichii, Classification system Ligusticum chuanxiong Hort..Promote breath and open depression, method wind-dryness is wet, promoting blood circulation and stopping pain.
Control air-cooled headache rotation dizzy, hypochondriac pain abdomen pain, arthritis muscle contraction, Amenorrhea, difficult labour, postpartum stasis block bitterly, ulcer sores.For menstruation not
Adjust, closed dysmenorrhea, lump in the abdomen stomachache, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.
Divine Comedy, Chinese medicine name.For polygonum flaccidum, sweet wormwood, almond mud, rde bean, fresh achene of Siberian cocklebur addition flour or wheat bran after fermentation
Into herbal leaven.Digesting and absorbing the essence of foodstuff place is eaten, and crux stagnates, invigorating the spleen warm stomach.
The present invention based on motherland's medical science to the pathogenetic understanding of gout and principle of reatment, with reference to modern pharmacology research into
Just, with reference to the modern times about research data and long-term clinical practice, it is believed that have inseparable relation between spleen, kidney, this disease is more
Factor body insufficiency of natural endowment, feels the damp and hot heresy of chill again, causes QI-blood circulation not smooth, is hindered through vessle-Bi symptom-complex, or phlegm-turbidity and blood stasis blood, hinders in passages through which vital energy circulates,
Go deep into muscles and bones joint passages through which vital energy circulates, be this sick pathogenesis, internal blood uric acid is removed rapidly.Therefore, the present invention filters out dampness elimination and rushes down
It is turbid, remove obstruction in channels to relieve pain, the promoting blood circulation therapy such as heat-clearing, to reach the purpose for the treatment of gout.
The present invention cures mainly function：Clearing heat and promoting diuresis, eliminating the phlegm have one's ideas straightened out, it is promoting blood circulation and removing obstruction in channels, replenish qi to invigorate the spleen.The present invention adapts to symptom：With
Redness and swelling of joints heat pain, gout for mutually fight in damp and hot turbid poison, the wet bet of spleen, fever and chills, causing etc..
Specific embodiment
Embodiment 1
Weigh the raw material to 200 mesh fine powders through drying and crushing：3 grams of Radix Codonopsis, 2 grams of smilax, 2 grams of the root of Chinese clematis, 2 grams of the Radix Astragali,
1 gram of pseudo-ginseng, 1 gram of the bark of ash, 1 gram of arisaema cum bile fries 1 gram of rhizoma atractylodis, 1 gram of first pearl, 1 gram of black-snake, windproof 1 gram, 1 gram of peach kernel, safflower 1
Gram, 1 gram of cassia twig, 1 gram of Ligusticum wallichii, 1 gram of Divine Comedy.The above-mentioned raw material for weighing is mixed, medicinal powder is made, loads capsule.
The present invention for treating the medicine of gout, 3 times a day, one time 7 grams, use warm boiled water.
In order to show therapeutic effect of the medicine of the present invention to gout, it is used to treat Chongqing Tong Kang orthopaedics doctors using embodiment 1
Institute's patient with gout 100.
Selection tcm diagnosis gout is standard：Patient has hyperuricemia, often in midnight joint have an intense pain, usually joint
Red, swollen, hot, pain, limitation of activity, articular cavity has hydrops, tophus precipitation occurs.As above symptom, you can make a definite diagnosis.Making a definite diagnosis observation
Object in, male 80, women 20, without other serious diseases, the age is -70 years old 35 years old, average age 51.4 years old.Take
The Chinese medicine composition of embodiment 1,3 times a day, one time 7 grams, with warm boiled water, continuously take 30 days.During clinical trial, withdraw it
Its medicine and health nutrient.
Efficacy determination：
It is effective：Constitution strengthens, and body is energetically；Hyperuricemia is controlled, joint it is red, swollen, hot, be relieved bitterly；
Hydrops articuli is reduced.
Effectively：Constitution strengthens, and body is energetically；Red, swollen, hot, the pain in joint have mitigated.
It is invalid：Illness is unchanged.
As a result：Responder 92, effective person 8, total effective rate is up to 100%.The present invention has no toxic side effect and adverse reaction,
It is adapted to patient with gout long-term treatment.
Model case：
Zhang, man, 52 years old, has gout history 9 years, and uric acid of having a blood test is 550umol/L；Left wrist joint is red and swollen, moving obstacle, clothes
With the Chinese medicine composition of embodiment 1,3 times a day, one time 7 grams, with warm boiled water, after taking 30 days, left wrist joint is red and swollen to disappear,
Blood uric acid is 465umol/L, and after continuing to take 15 days, blood uric acid is 450umol/L, and left wrist joints moving is freely.Follow-up, so far
Without recurrence.
The present invention based on motherland's medical science to the pathogenetic understanding of gout and principle of reatment, with reference to modern pharmacology research into
Just, with reference to the modern times about research data and long-term clinical practice, it is believed that have inseparable relation between spleen, kidney, this disease is more
Factor body insufficiency of natural endowment, feels the damp and hot heresy of chill again, causes QI-blood circulation not smooth, is hindered through vessle-Bi symptom-complex, or phlegm-turbidity and blood stasis blood, hinders in passages through which vital energy circulates,
Go deep into muscles and bones joint passages through which vital energy circulates, be this sick pathogenesis, internal blood uric acid is removed rapidly.Therefore, the present invention filters out dampness elimination and rushes down
It is turbid, remove obstruction in channels to relieve pain, the promoting blood circulation therapy such as heat-clearing, to reach the purpose for the treatment of gout.
The present invention cures mainly function：Clearing heat and promoting diuresis, eliminating the phlegm have one's ideas straightened out, it is promoting blood circulation and removing obstruction in channels, replenish qi to invigorate the spleen.The present invention adapts to symptom：With
Redness and swelling of joints heat pain, gout for mutually fight in damp and hot turbid poison, the wet bet of spleen, fever and chills, causing etc..
Embodiment 2
Weigh the raw material to 200 mesh fine powders through drying and crushing：3 grams of Radix Codonopsis, 2 grams of smilax, 2 grams of the root of Chinese clematis, 2 grams of the Radix Astragali,
1 gram of pseudo-ginseng, 1 gram of the bark of ash, 2 grams of arisaema cum bile fries 1 gram of rhizoma atractylodis, 1 gram of first pearl, 1 gram of black-snake, windproof 1 gram, 1 gram of peach kernel, safflower 1
Gram, 1 gram of cassia twig, 1 gram of Ligusticum wallichii.The above-mentioned raw material for weighing is mixed, medicinal powder is made, loads capsule.
Embodiment 3
Weigh the raw material to 200 mesh fine powders through drying and crushing：3 grams of Radix Codonopsis, 2 grams of smilax, 2 grams of the root of Chinese clematis, 2 grams of the Radix Astragali,
1 gram of pseudo-ginseng, 1 gram of the bark of ash, 1 gram of rhizoma atractylodis of stir-fry, 1 gram of first pearl, 1 gram of black-snake, windproof 1 gram, 1 gram of peach kernel, 1 gram of safflower, 1 gram of cassia twig,
1 gram of Ligusticum wallichii, 2 grams of Divine Comedy.The above-mentioned raw material for weighing is mixed, medicinal powder is made, loads capsule.
Embodiment 4
S1, prepare each bulk drug according to following weight parts：
3 grams of Radix Codonopsis, 2 grams of smilax, 2 grams of the root of Chinese clematis, 2 grams of the Radix Astragali, 1 gram of pseudo-ginseng, 1 gram of the bark of ash, 1 gram of arisaema cum bile fries rhizoma atractylodis 1
Gram, 1 gram of first pearl, 1 gram of black-snake, windproof 1 gram, 1 gram of peach kernel, 1 gram of safflower, 1 gram of cassia twig, 1 gram of Ligusticum wallichii, 1 gram of Divine Comedy.
S2, above ingredients, plus the ethanol solution that concentration of volume percent is 70% are extracted, and the weight of ethanol solution is
10 times of the medicinal material gross weight, extract 2 times, and 1 hour every time, ethanol extract reclaimed ethanol, and phase is determined when being concentrated into 80 DEG C
It is 1.25 medicinal extract to density, obtains extraction extractum A, the dregs of a decoction is standby.
The dregs of a decoction that S3, step S2 are obtained, extracting in water, the weight of water is 10 times of medicinal material gross weight, extracts 2 times, every time 1
Hour, the medicinal extract that relative density is 1.25 is determined when aqueous extract is concentrated into 80 DEG C, medicinal extract B must be extracted.
S4, extractum A will be extracted and medicinal extract B will be extracted merged, and obtained and always extract medicinal extract, dried, obtain dry extract.
S5, by above-mentioned dry extract, the general pelletization of water.
Embodiment 5
S1, prepare each bulk drug according to following weight parts：
3 grams of Radix Codonopsis, 2 grams of smilax, 2 grams of the root of Chinese clematis, 2 grams of the Radix Astragali, 1 gram of pseudo-ginseng, 1 gram of the bark of ash, 1 gram of arisaema cum bile fries rhizoma atractylodis 1
Gram, 1 gram of first pearl, 1 gram of black-snake, windproof 1 gram, 1 gram of peach kernel, 1 gram of safflower, 1 gram of cassia twig, 1 gram of Ligusticum wallichii, 1 gram of Divine Comedy.
S2, above ingredients, plus the ethanol solution that concentration of volume percent is 70% are extracted, and the weight of ethanol solution is
10 times of the medicinal material gross weight, extract 2 times, and 1 hour every time, ethanol extract reclaimed ethanol, and phase is determined when being concentrated into 80 DEG C
It is 1.25 medicinal extract to density, obtains extraction extractum A, the dregs of a decoction is standby.
The dregs of a decoction that S3, step S2 are obtained, plus the ethanol solution that concentration of volume percent is 70% is extracted, the weight of ethanol solution
It is 10 times of the medicinal material gross weight to measure, and is extracted 2 times, and 1 hour every time, ethanol extract reclaimed ethanol, was surveyed when being concentrated into 80 DEG C
Determine the medicinal extract that relative density is 1.25, medicinal extract B must be extracted.
S4, extractum A will be extracted and medicinal extract B will be extracted merged, and obtained and always extract medicinal extract, dried, obtain dry extract.
S5, by above-mentioned dry extract, the general pelletization of water.
Embodiment 6
S1, prepare each bulk drug according to following weight parts：
3 grams of Radix Codonopsis, 2 grams of smilax, 2 grams of the root of Chinese clematis, 2 grams of the Radix Astragali, 1 gram of pseudo-ginseng, 1 gram of the bark of ash, 1 gram of arisaema cum bile fries rhizoma atractylodis 1
Gram, 1 gram of first pearl, 1 gram of black-snake, windproof 1 gram, 1 gram of peach kernel, 1 gram of safflower, 1 gram of cassia twig, 1 gram of Ligusticum wallichii, 1 gram of Divine Comedy.
S2, above ingredients, extracting in water, the weight of water is 10 times of the medicinal material gross weight, extracts 2 times, every time 1
Hour, the medicinal extract that relative density is 1.25 is determined when aqueous extract is concentrated into 80 DEG C, extraction extractum A is obtained, the dregs of a decoction are standby.
The dregs of a decoction that S3, step S2 are obtained, extracting in water, the weight of water is 10 times of medicinal material gross weight, extracts 2 times, every time 1
Hour, the medicinal extract that relative density is 1.25 is determined when aqueous extract is concentrated into 80 DEG C, medicinal extract B must be extracted.
S4, extractum A will be extracted and medicinal extract B will be extracted merged, and obtained and always extract medicinal extract, dried, obtain dry extract.
S5, by above-mentioned dry extract, the general pelletization of water.
Embodiment 7
Y1 weighs ingredients according to the weight portion, and 200 mesh fine powders are crushed to respectively, mixing；
Chinese medicine preparation：3 grams of Radix Codonopsis, 2 grams of smilax, 2 grams of the root of Chinese clematis, 2 grams of the Radix Astragali, 1 gram of pseudo-ginseng, 1 gram of the bark of ash, arisaema cum bile 1
Gram, fry 1 gram of rhizoma atractylodis, 1 gram of first pearl, 1 gram of black-snake, windproof 1 gram, 1 gram of peach kernel, 1 gram of safflower, 1 gram of cassia twig, 1 gram of Ligusticum wallichii, Divine Comedy 1
Gram.
Y2, for 70% ethanol is extracted, obtains extract solution with concentration of volume percent；
Y3 extract solution is condensed into the thick paste that density is 1.30g/mL (20 DEG C), is dried to constant weight at a temperature of 60 DEG C, is crushed
Cross 100 mesh sieves, then the general pelletization of water.
Extracting method is Microwave Extraction in the step Y2, and feed liquid mass ratio is 1：30；The Microwave Extraction is divided into three ranks
Duan Jinhang, first stage Extracting temperature is 50 DEG C, and extraction time is 10min, and microwave power is 700W, second stage Extracting temperature
It is 90 DEG C, extraction time is 40min, microwave power is 300W, and phase III Extracting temperature is 50 DEG C, and extraction time is 10min,
Microwave power is 700W；Obtain extract solution.
Embodiment 8
Substantially with embodiment 7, difference is step Y2.
Extracting method is Microwave Extraction in the step Y2, and feed liquid mass ratio is 1：30；The Microwave Extraction is divided into second order
Duan Jinhang, first stage Extracting temperature is 50 DEG C, and extraction time is 20min, and microwave power is 700W, second stage Extracting temperature
It it is 90 DEG C, extraction time is 40min, microwave power is 300W；Obtain extract solution.
Embodiment 9
Substantially with embodiment 7, difference is step Y2.
Extracting method is Microwave Extraction in the step Y2, and feed liquid mass ratio is 1：30；The Microwave Extraction is divided into second order
Duan Jinhang, first stage Extracting temperature is 90 DEG C, and extraction time is 40min, and microwave power is 300W, second stage Extracting temperature
It it is 50 DEG C, extraction time is 20min, microwave power is 700W；Obtain extract solution.
Test case 1：
The experimental study of Studies on Animal Models of Hyperuricemic Mice is caused to xanthine
1st, experiment material
Animal：Cleaning grade Kunming mouse 80, male, 20g ± 2g.
Medicine：Embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5, embodiment 6 prepare for treat pain
The medicine of wind.
Xanthine：Chemical Reagent Co., Ltd., Sinopharm Group.
Blood urine acid detection kit：Shanghai Rongsheng Bioisystech Co., Ltd.
2nd, experimental technique
Kunming mouse is randomly divided into 8 groups, i.e. Normal group, 1 group of embodiment, 2 groups of embodiment, implementation after entering laboratory
3 groups of example, 4 groups of embodiment, 5 groups of embodiment, 6 groups of embodiment, model control group every group 10, weigh and number；
After adaptability is fed 1 week, gavage gives distilled water (Normal group), the suspension of embodiment 1 (quite to each group respectively
In crude drug 8g/60mL), the suspension of embodiment 2 (equivalent to crude drug 8g/60mL), the suspension of embodiment 3 is (equivalent to crude drug 8g/
60mL), the suspension of embodiment 4 (equivalent to crude drug 8g/60mL), the suspension of embodiment 5 (equivalent to crude drug 8g/60mL), implementation
The suspension of example 6 (equivalent to crude drug 8g/60mL), distilled water (model control group)；Press body weight 0.3mL/10g gavages, daily 2
It is secondary, for three days on end.
1h after last gavage, Normal group intraperitoneal injection of saline 0.1mL/10g, remaining 7 groups of intraperitoneal injection 10%
Xanthine suspension 0.1mL/10g carries out modeling, is surveyed uric acid level and measurement result carried out with plucking eyeball method and take blood examination after 0.5h
Statistical analysis, experimental result see the table below.
Influence table to Studies on Animal Models of Hyperuricemic Mice blood uric acid
Note：* represent to compare with Normal group have significant differences P<0.05.
Test result indicate that, Studies on Animal Models of Hyperuricemic Mice success, for treating the medicine of gout to mouse antihyperuricemic
Disease model has anti-trioxypurine to act on.
Claims (10)
1. a kind of medicine for treating gout, counts by weight, including the medicament that following raw materials are made：Radix Codonopsis 20-40 parts,
Smilax 10-30 parts, root of Chinese clematis 10-30 parts, Radix Astragali 10-30 parts, pseudo-ginseng 5-15 parts, bark of ash 5-15 parts, fry 5-15 parts of rhizoma atractylodis, first
It is pearl 5-15 parts, black-snake 5-15 parts, windproof 5-15 parts, peach kernel 5-15 parts, safflower 5-15 parts, cassia twig 5-15 parts, Ligusticum wallichii 5-15 parts.
2. the medicine for being used to treat gout as claimed in claim 1, counts by weight, including the medicine that following raw materials are made
Agent：Radix Codonopsis 20-40 parts, smilax 10-30 parts, root of Chinese clematis 10-30 parts, Radix Astragali 10-30 parts, pseudo-ginseng 5-15 parts, bark of ash 5-15 parts,
5-15 parts of rhizoma atractylodis are fried, 5-15 parts of first pearl is black-snake 5-15 parts, windproof 5-15 parts, peach kernel 5-15 parts, safflower 5-15 parts, cassia twig 5-
15 parts, Ligusticum wallichii 5-15 parts, Divine Comedy 10-30 parts.
3. the medicine for being used to treat gout as claimed in claim 1, counts by weight, including the medicine that following raw materials are made
Agent：Radix Codonopsis 20-40 parts, smilax 10-30 parts, root of Chinese clematis 10-30 parts, Radix Astragali 10-30 parts, pseudo-ginseng 5-15 parts, bark of ash 5-15 parts,
Arisaema cum bile 10-30 parts, 5-15 parts of rhizoma atractylodis are fried, 5-15 parts of first pearl is black-snake 5-15 parts, windproof 5-15 parts, peach kernel 5-15 parts, safflower
5-15 parts, cassia twig 5-15 parts, Ligusticum wallichii 5-15 parts.
4. the medicine planted for treating gout as claimed in claim 1, counts by weight, is the medicine being made up of following raw materials
Agent：Radix Codonopsis 20-40 parts, smilax 10-30 parts, root of Chinese clematis 10-30 parts, Radix Astragali 10-30 parts, pseudo-ginseng 5-15 parts, bark of ash 5-15 parts,
Arisaema cum bile 5-15 parts, 5-15 parts of rhizoma atractylodis are fried, 5-15 parts of first pearl is black-snake 5-15 parts, windproof 5-15 parts, peach kernel 5-15 parts, safflower
5-15 parts, cassia twig 5-15 parts, Ligusticum wallichii 5-15 parts, Divine Comedy 5-15 parts.
5. it is used to treat the medicine of gout according to claim 4, it is characterised in that described medicament is any medicament
Described formulation on.
6. it is used to treat the medicine of gout according to claim 5, it is characterised in that described medicament is powder, the water-bindered pill, block
Agent, honeyed bolus or capsule.
7. it is used to treat the medicine of gout according to claim 6, it is characterised in that described medicament is the water-bindered pill.
8. a kind of preparation method of medicine for treating gout as any one of claim 1-6, including following step
Suddenly：By the raw material drying, 100-200 mesh fine powders are crushed to, sieved；Mix in a ratio, be made medicament.
9. the preparation method of the medicine for being used to treat gout as claimed in claim 7, comprises the following steps：
S1 prepares each bulk drug according to the weight portion；
More than S2 ingredientss, plus concentration of volume percent is the ethanol solution extraction of 60-80%, and the weight of ethanol solution is institute
State medicinal material gross weight 8-12 times, extracts 2-3 times, each 0.5-2 hours, and ethanol extract reclaims ethanol, when being concentrated into 80 DEG C
It is the medicinal extract of 1.20-1.30 to determine relative density, obtains extraction extractum A, and the dregs of a decoction are standby；
The dregs of a decoction that S3 steps S2 is obtained, extracting in water, the weight of water is 5-15 times of medicinal material gross weight, extraction 2-3 times, every time
0.5-2 hours, it was the medicinal extract of 1.20-1.30 that aqueous extract determines relative density when being concentrated into 80 DEG C, must extract medicinal extract B；
S4 will extract extractum A and extract medicinal extract B and merge, and obtain and always extract medicinal extract, dry, and obtain dry extract；
S5 by above-mentioned dry extract, the general pelletization of water.
10. the preparation method of the medicine for being used to treat gout as claimed in claim 7, comprises the following steps：
Y1 weighs ingredients according to the weight portion, crushes respectively, mixing；
Y2 is that 65-95% ethanol is extracted with concentration of volume percent, obtains extract solution；
Extract solution is concentrated, dried, the general pelletization of water by Y3.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112891486A (en) * | 2021-04-25 | 2021-06-04 | 上海云梯医药科技有限公司 | Chinese herbal medicine formula and electuary capable of regulating three highs and spontaneously discharging uric acid |
| CN113679796A (en) * | 2021-09-09 | 2021-11-23 | 重庆同康骨科医院有限公司 | Medicine for treating gout and preparation method thereof |
| CN113730496A (en) * | 2021-10-08 | 2021-12-03 | 重庆同康骨科医院有限公司 | Astragalus root gout tablet and preparation method thereof |
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| CN103393865A (en) * | 2013-07-29 | 2013-11-20 | 肖变化 | Medicament for treating gout and preparation method thereof |
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| CN103393865A (en) * | 2013-07-29 | 2013-11-20 | 肖变化 | Medicament for treating gout and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112891486A (en) * | 2021-04-25 | 2021-06-04 | 上海云梯医药科技有限公司 | Chinese herbal medicine formula and electuary capable of regulating three highs and spontaneously discharging uric acid |
| CN113679796A (en) * | 2021-09-09 | 2021-11-23 | 重庆同康骨科医院有限公司 | Medicine for treating gout and preparation method thereof |
| CN113730496A (en) * | 2021-10-08 | 2021-12-03 | 重庆同康骨科医院有限公司 | Astragalus root gout tablet and preparation method thereof |
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