CN106727683A - A kind of application of pharmaceutical preparation in the medicine for preparing treatment helicobacter pylori infections disease - Google Patents
A kind of application of pharmaceutical preparation in the medicine for preparing treatment helicobacter pylori infections disease Download PDFInfo
- Publication number
- CN106727683A CN106727683A CN201611203590.3A CN201611203590A CN106727683A CN 106727683 A CN106727683 A CN 106727683A CN 201611203590 A CN201611203590 A CN 201611203590A CN 106727683 A CN106727683 A CN 106727683A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical preparation
- iodine
- helicobacter pylori
- medicine
- elemental iodine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A kind of application of the present invention for pharmaceutical preparation in the medicine for preparing treatment helicobacter pylori infections disease, the pharmaceutical preparation is a kind of pharmaceutical preparation containing elemental iodine or iodine compound, there is molecular iodine in the aqueous solution of the pharmaceutical preparation containing elemental iodine or iodine compound, pharmaceutical preparation containing elemental iodine or iodine compound is preparing treatment stomach, application in the medicine of duodenum helicobacter pylori infections disease, eradicate stomach, ID helicobacter pylori, safety, effectively, do not produce drug resistance, adverse reaction is few and slight, short treating period, it is convenient to take, price is relatively low.
Description
Technical field
A kind of application of the present invention for pharmaceutical preparation in the medicine for preparing treatment helicobacter pylori infections disease.
Background technology
Helicobacter pylori infections disease is a kind of in the communicable disease propagated between men.
Helicobacter pylori (Helicobacter pylori) infectious diseases is a global problem.Quilt in 1994
The World Health Organization (World Health Organization, WHO) and international cancer research institution (International
Agency For Research on Cancer, IARC)) the I class carcinogens of Human Gastric carcinoma are classified as, helicobacter pylori turns into
The bacterium of such harmful grade positioning is uniquely obtained so far.
Mainly by oral cavity route into gastric pattern epithelium is colonized in human stomach, body is difficult helicobacter pylori after field planting
Spontaneous removing, and almost can cause gastric mucosa Active inflammation, can also occur on the basis of Active inflammation chronic gastritis,
A series of common diseases such as atrophic gastritis, peptic ulcer and stomach cancer, severely compromise the health of people, to personal band
Great disaster is carried out, very big medical burden also has been constituted to family and country.
It is now recognized that intestinal-type gastric cancer follows Correa patterns, superficial gastritis → atrophic gastritis → enteric epithelium
Life → dysplasia → canceration, helicobacter pylori infections have the effect for starting and promoting its development, early stage in this course
Eradicating helicobacter pylori can suppress the progress of atrophic gastritis, almost can thoroughly eliminate the risk of intestinal-type gastric cancer generation.
In September, 2015《The common recognition report of the helicobacter pylorus gastritis capital of a country whole world》In an international common recognition reaching：Pylorus
Pylori (Hp) infection person all should be given eradication therapy！Eradicate helicobacter pylori, the then chronic stomach for being caused by helicobacter pylori infections
A series of diseases such as inflammation, atrophic gastritis, peptic ulcer and stomach cancer can be eased, stable or recovery from illness, and patient will obtain
Maximum taking-imitate is obtained to compare；Particularly early stage Eliminating H. pylori Infection by Means, almost can thoroughly eliminate the wind of intestinal-type gastric cancer generation
Danger.
Helicobacter Pylori Infection Rate is up to 40-60% in the crowd of China 1,300,000,000；WHO data shows, China's stomach in 2012
Cancer new cases and death respectively may be about the 42.5% and 45.0% of the whole world；Its infection and relevant disease to prevent and treat task non-
It is often heavy.Someone counts, and eradicates helicobacter pylori person, and it is 18 times after eradicating not obtain the preceding cost for complication of radical cure.
The subject matter of the preventing and treating of helicobacter pylori infections disease not whether need eradicate helicobacter pylori, but should
How effectively to be eradicated on helicobacter pylori when being primarily focused on！
However, the preventing and treating of helicobacter pylori infections disease, is a current global problem！Even more China's pylorus
The stern challenge that pylori (Hp) infection preventing and treating is faced with！
China's helicobacter pylori infections radix is big, and about 6.5 hundred million！This is the very serious society that China faces at present
Problem and a heavy financial burden；Also without a kind of preferable medicine in treatment, vaccine research does not make a breakthrough also.
The antibiotic of conventional elimination helicobacter pylori, Hp Drug Resistance rate is high, and eradication rate is low：There is no single medicine
Helicobacter pylori can effectively be eradicated；CLA resistant rate is 20%~40%, and metronidazole resistant rate is 60%~80%, left oxygen
Flucloxacillin resistant rate is 20%~35%, and Amoxicillin resistant rate is 1%~5%, and furazolidone resistant rate is 1%~5%, four
Ring element resistant rate is 1%~5%；The extension antibiotic usage course for the treatment of, the effect for improving curative effect is very limited.
All there are various adverse reactions in conventional radical cure Stomach duodenum helicobacter pylori antibiotic：Amoxicillin can draw
Rise stomachache, diarrhoea, Nausea and vomiting, medicine heat, exfoliative dermatitis, asthma, shock, Neuroleptic Leukocytopenia, transaminase rising, acute
Matter pneumonia, pseudomembranous enteritis；CLA can cause stomachache, diarrhoea, Nausea and vomiting, pseudomembranous enteritis, Clostridium difficile gemma
The adverse reactions such as bacilus diarrhoea, transaminase rising, hepatotoxicity wind agitation, allergy；Levofloxacin magnitude QNS can cause evil
The heart, vomiting, headache, insomnia, dizziness, induction epilepsy, allergic reaction, hepatorenal damage, myasthenia gravis, angioneurotic edema；
Tetracycline can cause Nausea and vomiting, stomachache, diarrhoea, esophagitis, esophageal ulcer, pancreatitis, pseudomembranous enteritis, Clostridium difficile bud
Spore bacilus diarrhoea, hepatotoxicity wind agitation, renal toxicity, uremia, hemolytic anemia, decrease of platelet, Neutrophilic granulocytopenia, nettle
Rash, angioneurotic edema, anaphylactoid purpura, pericarditis, systemic lupus erythematosis, anaphylactic shock, asthma；Metronidazole can
Cause Nausea and vomiting, eilema, dizziness, incoordination and convulsions；Furazolidone can cause Nausea and vomiting, medicine heat, asthma, head
Bitterly, polyneuritis, postural hypotension, hypoglycemia；Eradication therapy makes patient subject greatly pain and risk；In
Medicine, is improved the report of helicobacter pylori eradicating rate, but need more checkings and study.
The drug combination of antibiotic is low to Stomach duodenum helicobacter pylori eradicating rate, is difficult finally to eliminate helicobacter pylorus
Bacterium：Thirdly connection, the standard scheme eradication rate of 10 days have been less than 80%；Its tetrad, the course for the treatment of standard scheme eradication rate of 14 days are reachable
96%；Be used in combination and the very long course for the treatment of of Multiple Classes of Antibiotics, even various adverse reactions, serious adverse reaction are also easy to produce,
Have to stopped treatment.
Eradicate Stomach duodenum helicobacter pylori and often want being used in combination and the course for the treatment of more long for Multiple Classes of Antibiotics, but this
Addition or the mutual promoting action of various toxic and side effects can be caused, even more serious adverse reaction occurs, even result in death！
Antibiotic destroys the normal ecological balance of enteron aisle, and such as pseudomembranous enteritis, clostridium difficile diarrhoea occur
Serious adverse reaction.
Carry out eradicating Stomach duodenum Eradication Therapy of Helicobacter pylori Infection in substantial amounts of crowd, stomach, 12 are eradicated using antibiotic
Although duodenum 12 helicobacter pylori infections are inevitable choices, but for the mankind control numerous bacterial infection diseases, really
It is in fact the abuse of antibiotic, the generation of super drug-resistant bacteria can be caused, mankind's control bacterial infection disease can be brought extremely
Serious consequence.
In face of the failure of Stomach duodenum helicobacter pylori eradication or Stomach duodenum Helicobacter pylori reinfection, doctor's beam
Hand is without plan；The treatment experience of Stomach duodenum helicobacter pylori is eradicated first, and patient is even more absorbed in anxiety, uneasiness, fears dearly
Fear and despair！
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical preparation in the medicine for preparing treatment helicobacter pylori infections disease
Application, the pharmaceutical preparation prepare treatment Stomach duodenum helicobacter pylori infections disease medicine in application, energy
Thoroughly eradicate Stomach duodenum helicobacter pylori；The pharmaceutical preparation safely, effectively, do not produce drug resistance, adverse reaction is few and light
Micro-, short treating period, convenient to take, price is relatively low.
The present invention is achieved like this：A kind of pharmaceutical preparation is preparing the medicine for the treatment of helicobacter pylori infections disease
In application, the pharmaceutical preparation is a kind of pharmaceutical preparation containing elemental iodine or iodine compound, contains elemental iodine or iodate and closes
There is molecular iodine in the aqueous solution of the pharmaceutical preparation of thing, the pharmaceutical preparation containing elemental iodine or iodine compound prepare treatment stomach,
Application in the medicine of duodenum helicobacter pylori infections disease, eradicates helicobacter pylori in Stomach duodenum.The application
The formulation of the pharmaceutical preparation containing elemental iodine or iodine compound described in file can be aqua, pulvis, pill, powder, tablet,
Granula, electuary, capsule etc. meet various formulations of pharmaceutical preparation requirement；Contain the medicine system of elemental iodine described in present specification
Agent refers to containing elemental iodine but to be not limited to comprise only elemental iodine in the composition, can also contain water, ethanol, iodate
Other one or more chemical substance such as potassium, chelated iodine, cosolvent；Pharmaceutical preparation containing iodine compound described in present specification
Refer to containing iodine compound but to be not limited to comprise only iodine compound in the composition, it is also possible to contain water, ethanol, iodine
Other one or more chemical substance such as simple substance, KI, chelated iodine, cosolvent；Iodine compound refers to described in present specification
Compound containing I in its molecular structure.
Iodine be wanted needed for human normal life process, essential element, iodine form present in human body with
Body is consistent, its concentration and quantity are maintained within the scope of certain, are harmless to human body.
The chemism of iodine is strong, by the halogenation of molecular iodine, is disturbed from many aspects or destruction human body cell, bacterium
The vital movement of cell or virion and play its killing action, it is including the protein denaturation of cell membrane or cell membrane, precipitation, solidifying
Admittedly cell membrane or membrane passage is changed even cell rupture and is caused cell death, also including human body cell, bacterium
Cell or viral vivo protein are denatured, precipitate, solidify and influence nucleic acid to synthesize, hinder hereditary information duplication, be metabolized change, enzyme
Loss of activity, protein dyssynthesis etc. and cause human body cell, bacterial cell or virion dead.Molecular iodine is with antibiotic not
Together, there is no strict antimicrobial spectrum, there is no obvious selection index system to pathogen and tissue, killing or suppressing pathogen
Concentration under, often also energy loss victimization body, is extensive, absolute and does not have to the damage effect of human body cell, bacterium and virus
Selectively；Traditional viewpoint is that the pharmaceutical preparation containing molecular iodine is can not to take the medicine for bacterium infection orally, is only
The Cidex-7 thing of body surface can be used for.
Iodide ion has no direct detrimental effect to human tissue cell；Under normal circumstances, in Stomach duodenum
The absorption of iodine is to be entered blood circulation by absorption in the way of iodide ion, will not be followed into blood by absorption in the form of molecular iodine
Ring, is also seldom entered blood circulation by absorption in the form of organoiodine compound molecule；When in the aqueous solution in Stomach duodenum
When there is molecular iodine, dynamic equilibrium is there is between iodide ion and molecular iodine；Iodide ion in Stomach duodenum, there is a small amount of
Iodide ion blood circulation is constantly absorbed into stomach and is transported, substantial amounts of iodide ion is constantly absorbed in duodenum
Into blood circulation and transport；With iodide ion continuous absorption and transport, molecular iodine and iodide ion are constantly reduced, finally, enter
A number of molecular iodine and iodide ion in Stomach duodenum reach 12 by regular hour, process, displacement
During end in duodenum 12, exist almost without molecular iodine and iodide ion.
Into human body helicobacter pylori it is natural field planting position in gastric epithelial surface and the bottom of gastric mucous layer,
Field planting can not enter among blood circulation and its hetero-organization in Duodenal Mucosa gastric metaplasia region；In antibiotic or
The interference of other unfavorable conditions or under the influence of, there is spherical change in helicobacter pylori, can directly stick and to enter gastric epithelial thin
In born of the same parents, still with infectivity；The helicobacter pylori antibiotic in conventional elimination Stomach duodenum is generally to can absorb and enter at present
Enter the antibiotic of blood circulation, although or be difficult to be absorbed, by it is whole it is gastral during there is site of action and do not have
Species that is selective, killing bacterium is also without selectivity；Regrettably, for a long time, medicine expert, medical science are special
Family, have ignored the further research to the sterilization antisepsis of iodine, traditional viewpoint be it is inveteracy think, containing dividing
The pharmaceutical preparation of sub- iodine can only outward be used for the sterilization of skin or mucous membrane；Treatment is being prepared according to a kind of pharmaceutical preparation of the present invention
Application in the medicine of Stomach duodenum helicobacter pylori infections disease, eradicates the helicobacter pylori in Stomach duodenum,
The sufficient understanding and cognitions a variety of to this are come from, certainly, is also far from not much else！
According to the present invention, a kind of application of pharmaceutical preparation in the medicine for treating helicobacter pylori infections disease is prepared,
The pharmaceutical preparation is a kind of pharmaceutical preparation containing elemental iodine or iodine compound, the medicine system containing elemental iodine or iodine compound
There is molecular iodine in the aqueous solution of agent；After pharmaceutical preparation containing elemental iodine or iodine compound enters Stomach duodenum, it is mixed in
Among liquid in Stomach duodenum, dynamic equilibrium, also, molecular iodine and iodide ion are there is between molecular iodine and iodide ion
It is permeable in gastric epithelial surface and gastric mucous layer, is yet permeable to the liquid of Duodenal Mucosa epithelial surface and enteric cavity
In body；Molecular iodine infiltrate into the helicobacter pylori in Stomach duodenum where all spaces, including helicobacter pylori is colonized
Gastric epithelial surface and gastric mucous layer bottom and the Duodenal Mucosa gastric metaplasia area that is colonized, by molecule
The halogenation of iodine, disturbs from many aspects or destroys the vital movement of helicobacter pylori and play its bactericidal action；Contain iodine
The pharmaceutical preparation of simple substance or iodine compound answering in the medicine for preparing treatment Stomach duodenum helicobacter pylori infections disease
With the helicobacter pylori in elimination Stomach duodenum；Sufficient amount of molecular iodine is complete to the killing action of helicobacter pylori
, thoroughly, it is destructive, the basis of the life of helicobacter pylori has not existed, and is not in helicobacter pylori to molecular iodine
Produce the problem of drug resistance.
According to the present invention, a kind of application of pharmaceutical preparation in the medicine for treating helicobacter pylori infections disease is prepared,
The pharmaceutical preparation is a kind of pharmaceutical preparation containing elemental iodine or iodine compound, the medicine system containing elemental iodine or iodine compound
There is molecular iodine in the aqueous solution of agent；Pharmaceutical preparation containing elemental iodine or iodine compound or its aqueous solution enter stomach, 12 fingers
After intestines, it is mixed among the liquid in Stomach duodenum, dynamic equilibrium is there is between molecular iodine and iodide ion, stomach, 12 refers to
The iodine of enteral is absorbed by stomach lining, particularly in the way of iodide ion by Duodenal Mucosa again, and continuous with iodide ion
Absorb, transported into blood circulation, the quantity of iodide ion is constantly reduced, and causes the quantity of iodine molecule constantly to reduce, finally, ten
End in two duodenum 12, molecular iodine and iodide ion are almost absorbed completely, several in the alimentary canal after duodenal end
Do not exist iodine molecule；The significance of this process and result is, provided by the present invention containing elemental iodine or iodine compound
Pharmaceutical preparation or its aqueous solution alimentary canal of the bactericidal action after duodenal end in do not existed, neither deposit
Be rapidly absorbed into blood circulation in molecular iodine and cause the extensive infringement to body tissue, eliminate again to duodenal end with
Alimentary canal intestinal mucosa afterwards is injured, and also also avoid the bad anti-of flora imbalance in the later alimentary canal in duodenum end
Should；Pharmaceutical preparation containing elemental iodine or iodine compound is preparing treatment Stomach duodenum helicobacter pylori infections disease
Application in medicine, eradicates the helicobacter pylori in Stomach duodenum, and it is played kills the place of helicobacter pylori efficiency and imprison
Position where Helicobacter pylori, i.e. growth, breeding, pathogenic position, it is fully consistent, it is accurate, ingenious and perfect！Certainly, institute of the present invention
The pharmaceutical preparation containing elemental iodine or iodine compound for providing is used to eradicate the treatment of the helicobacter pylori in Stomach duodenum,
The grasp of its consumption and concentration, it is critical that, the pharmaceutical preparation being made up of elemental iodine or the medicine being made up of elemental iodine and water
There is molecular iodine in the aqueous solution of thing preparation, the concentration of iodine is the iodine of external test to the minimum of helicobacter pylori in the aqueous solution
1 to 30 times of bacteriocidal concentration, smaller concentration can cause the eradication rate of helicobacter pylori to reduce, and bigger concentration can not increase treatment
Effect, can increase on the contrary adverse reaction；
According to the present invention, a kind of application of pharmaceutical preparation in the medicine for treating helicobacter pylori infections disease is prepared,
The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine, and symbol can be added in the pharmaceutical preparation being made up of elemental iodine
The pharmaceutic adjuvant of composite medicine formulation requirements, it is prepared into the various formulations for meeting medicinal requirements；The pharmaceutical preparation being made up of elemental iodine
The aqueous solution in there is molecular iodine, after the pharmaceutical preparation being made up of elemental iodine enters Stomach duodenum, be mixed in stomach, 12 fingers
Among the liquid of enteral, dynamic equilibrium is there is between molecular iodine and iodide ion, also, molecular iodine and iodide ion are permeable to stomach
In mucosal epithelium surface and gastric mucous layer, yet it is permeable in the liquid of Duodenal Mucosa epithelial surface and its enteral；Point
Sub- iodine infiltrate into the helicobacter pylori in Stomach duodenum where all sites, including the stomach that is colonized of helicobacter pylori sticks
The bottom of film epithelial surface and gastric mucous layer and the Duodenal Mucosa gastric metaplasia area being colonized, by the halogen of molecular iodine
Change is acted on, and many-side is disturbed or destroyed the vital movement of helicobacter pylori and plays its bactericidal action；The medicine being made up of elemental iodine
Application of the thing preparation in the medicine for preparing treatment Stomach duodenum helicobacter pylori infections disease, eradicates Stomach duodenum
Interior helicobacter pylori.
According to the present invention, a kind of application of pharmaceutical preparation in the medicine for treating helicobacter pylori infections disease is prepared,
The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine and water, the pharmaceutical preparation being made up of elemental iodine and water it is water-soluble
There is molecular iodine in liquid；Can be added in the pharmaceutical preparation being made up of elemental iodine and water and meet the medicinal auxiliary of pharmaceutical preparation requirement
Material；After the pharmaceutical preparation being made up of elemental iodine and water enters Stomach duodenum, it is mixed among the liquid in Stomach duodenum,
There is dynamic equilibrium between molecular iodine and iodide ion, also, molecular iodine and iodide ion be permeable to gastric epithelial surface and
In gastric mucous layer, yet it is permeable in the liquid of Duodenal Mucosa epithelial surface and enteral；Molecular iodine infiltrates into stomach, 12
The all sites where helicobacter pylori in duodenum 12, including the gastric epithelial surface that is colonized of helicobacter pylori and stomach mucus
Bottom and the Duodenal Mucosa gastric metaplasia area that is colonized, by the halogenation of molecular iodine, many-side interference or
Destroy the vital movement of helicobacter pylori and play its bactericidal action；The pharmaceutical preparation being made up of elemental iodine and water is preparing treatment
Application in the medicine of Stomach duodenum helicobacter pylori infections disease, eradicates the helicobacter pylori in Stomach duodenum.
According to the present invention, a kind of application of pharmaceutical preparation in the medicine for treating helicobacter pylori infections disease is prepared,
The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine or the pharmaceutical preparation being made up of elemental iodine and water, by elemental iodine
There is molecular iodine in the aqueous solution of the pharmaceutical preparation of composition or the pharmaceutical preparation being made up of elemental iodine and water, iodine in the aqueous solution
Concentration be the iodine of external test to 1 to 30 times of the minimum bactericidal concentration of helicobacter pylori, smaller concentration can cause helicobacter pylorus
The eradication rate reduction of bacterium, bigger concentration can not increase curative effect, adverse reaction can on the contrary increased；The medicine being made up of elemental iodine
Thing preparation is preparing treatment Stomach duodenum helicobacter pylori infections disease by the pharmaceutical preparation that elemental iodine and water are constituted
Application in medicine, eradicates helicobacter pylori in Stomach duodenum.
According to the present invention, a kind of application of pharmaceutical preparation in the medicine for treating helicobacter pylori infections disease is prepared,
The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine or the pharmaceutical preparation being made up of elemental iodine and water, by elemental iodine
There is molecular iodine in the aqueous solution of the pharmaceutical preparation of composition or the pharmaceutical preparation being made up of elemental iodine and water, iodine in the aqueous solution
Concentration is 1~30mg/100ml, and smaller concentration can cause the eradication rate of helicobacter pylori to reduce, and bigger concentration can not increase
Curative effect, can increase on the contrary adverse reaction, and such as Nausea and vomiting, gastrointestinal tract inflammation, corrosion is rotten to the corn；The medicine being made up of elemental iodine
Preparation is preparing the medicine for the treatment of Stomach duodenum helicobacter pylori infections disease by the pharmaceutical preparation that elemental iodine and water are constituted
Application in thing, eradicates helicobacter pylori in Stomach duodenum.
According to the present invention, a kind of application of pharmaceutical preparation in the medicine for treating helicobacter pylori infections disease is prepared,
The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine or the pharmaceutical preparation being made up of elemental iodine and water, by elemental iodine
There is molecular iodine in the aqueous solution of the pharmaceutical preparation of composition or the pharmaceutical preparation being made up of elemental iodine and water, iodine in the aqueous solution
Concentration is 2~10mg/100ml；The pharmaceutical preparation that is made up of elemental iodine is being prepared by the pharmaceutical preparation that elemental iodine and water are constituted
The application in the medicine of Stomach duodenum helicobacter pylori infections disease is treated, helicobacter pylorus in Stomach duodenum are eradicated
Bacterium.
According to the present invention, a kind of application of pharmaceutical preparation in the medicine for treating helicobacter pylori infections disease is prepared,
The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine or the pharmaceutical preparation being made up of elemental iodine and water, by elemental iodine
There is molecular iodine in the aqueous solution of the pharmaceutical preparation of composition or the pharmaceutical preparation being made up of elemental iodine and water, iodine in the aqueous solution
Concentration is 3~8mg/100ml；The pharmaceutical preparation that is made up of elemental iodine is controlled by the pharmaceutical preparation that elemental iodine and water are constituted in preparation
The application in the medicine of Stomach duodenum helicobacter pylori infections disease is treated, helicobacter pylori in Stomach duodenum is eradicated.
According to the present invention, a kind of application of pharmaceutical preparation in the medicine for treating helicobacter pylori infections disease is prepared,
The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine or the pharmaceutical preparation being made up of elemental iodine and water, by elemental iodine
There is molecular iodine in the aqueous solution of the pharmaceutical preparation of composition or the pharmaceutical preparation being made up of elemental iodine and water, iodine in the aqueous solution
Concentration is 4~6mg/100ml；The pharmaceutical preparation that is made up of elemental iodine is controlled by the pharmaceutical preparation that elemental iodine and water are constituted in preparation
The application in the medicine of Stomach duodenum helicobacter pylori infections disease is treated, helicobacter pylori in Stomach duodenum is eradicated.
According to the present invention, a kind of application of pharmaceutical preparation in the medicine for treating helicobacter pylori infections disease is prepared,
The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine or the pharmaceutical preparation being made up of elemental iodine and water, by elemental iodine
There is molecular iodine in the aqueous solution of the pharmaceutical preparation of composition or the pharmaceutical preparation being made up of elemental iodine and water, iodine in the aqueous solution
Concentration is 5mg/100ml；The pharmaceutical preparation that is made up of elemental iodine or the pharmaceutical preparation that is made up of elemental iodine and water are treated preparing
Application in the medicine of Stomach duodenum helicobacter pylori infections disease, eradicates helicobacter pylori in Stomach duodenum.
According to the present invention, a kind of application of pharmaceutical preparation in the medicine for treating helicobacter pylori infections disease is prepared,
The iodine compound be it is a kind of in aqueous, before the chemical change that dissociation occurs and molecular iodine is produced, it is impossible to be digested
Road directly absorbs and the iodine compound of entrance blood circulation；Containing in aqueous, there is the chemistry for dissociating and producing molecular iodine
Before change, it is impossible to which the pharmaceutical preparation for directly being absorbed by alimentary canal and entering the iodine compound of blood circulation is preparing treatment stomach, ten
Application in the medicine of two duodenum 12 helicobacter pylori infections diseases, eradicates helicobacter pylori in Stomach duodenum, safer；
The iodine compound of molecular iodine can not be in aqueous dissociated and produced, does not possess the effect for killing helicobacter pylori；Can be water-soluble
The iodine compound of molecular iodine is dissociated and produced in liquid, just possesses the effect for killing helicobacter pylori；But, if one kind possesses
Kill helicobacter pylori activity iodine compound, in aqueous, occur dissociation and produce molecular iodine chemical change it
Before, can directly be absorbed by alimentary canal and enter blood circulation, then molecule can be dissociated and produced in human blood circulation and in tissue
Iodine, the universal cytotoxic effect of the non-selectivity of molecular iodine can injure the Various Tissues and organ of human body, particularly to human body
Hematological system, internal system, reproductive system, nervous system bring potential, uncertain or for quite a long time
Inside it is difficult the great risk observed in animal experiment or human trial；For these reasons, for that in the aqueous solution
In, before the chemical change that dissociation occurs and molecular iodine is produced, can directly be absorbed by alimentary canal and the iodate of entrance blood circulation
Application of the pharmaceutical preparation of compound in the medicine for preparing treatment Stomach duodenum helicobacter pylori infections disease, elimination stomach,
Helicobacter pylori in duodenum, should be careful, such as, and amino-acid complex iodine, lecithin chelated iodine, and but it is not limited only to amino
Sour chelated iodine, lecithin chelated iodine；Particularly amino-acid complex iodine, can in aqueous dissociate and produce molecular iodine, and,
In aqueous, before the chemical change that dissociation occurs and molecular iodine is produced, amino-acid complex iodine is to be easy to straight by alimentary canal
Connect absorption and enter blood circulation, in blood circulation or in tissue dissociation and produce molecular iodine and injure human body Various Tissues and
Organ；The tolerable maximum amount of the iodine that amino-acid complex iodine can directly be entered blood circulation by absorption is 1000 micrograms/day, even if
It is consumption in 1000 micrograms/below day, there is also potential, uncertain risk；Amino-acid complex iodine, oral 1000 is micro-
Gram/day does not reach the requirement for eradicating Stomach duodenum helicobacter pylori, and bigger concentration then may be because of the universal cell of non-selectivity
Toxic action and injure the Various Tissues and organ of human body；Therefore, the pharmaceutical preparation containing amino-acid complex iodine is preparing treatment
Application in the medicine of Stomach duodenum helicobacter pylori infections disease, should be careful.
According to the present invention, a kind of application of pharmaceutical preparation in the medicine for treating helicobacter pylori infections disease is prepared,
The iodine compound is iodamylum, is the complex compound of iodine and starch generation；Deposited in the aqueous solution of the pharmaceutical preparation containing iodamylum
In molecular iodine, iodamylum can dissociate and produce molecular iodine in aqueous, and it is flat to there is dynamic between molecular iodine and iodide ion
Weighing apparatus；Molecular iodine has killing action to human body cell, bacterial cell or virion；Iodamylum in aqueous, occur dissociation,
And before producing the chemical change of molecular iodine, iodamylum can not directly be absorbed by alimentary canal and enter blood circulation, thus blood circulation
In just do not exist iodamylum, molecular iodine is dissociated and produced in the absence of iodamylum and non-selectivity injures human tissue cell not
Good reaction；After iodamylum enters Stomach duodenum, molecular iodine is dissociated and produced, and there is dynamic between molecular iodine and iodide ion
Balance, iodide ion is constantly absorbed by Stomach duodenum；Starch can also discharge the molecular iodine being combined with monose is hydrolyzed to；
When iodamylum arrives at duodenum end, almost all dissociation, digestion, iodide ion, iodine molecule there's almost no, i.e., iodine forms sediment
The bactericidal action of powder has not so far existed；The concentration of iodine is 2~30mg/100ml in the aqueous solution, and smaller concentration eradicates pylorus
The effect of helicobacter can reduce, bigger concentration, eradicate effect increase not significantly its adverse reaction of helicobacter pylori
Dramatically increase；Consider, the concentration of iodine is 5~20mg/100ml in the aqueous solution, more particularly suitable；Medicine system containing iodamylum
Application of the agent in the medicine for preparing treatment Stomach duodenum helicobacter pylori infections disease, eradicates in Stomach duodenum
Helicobacter pylori, safely, effectively, adverse reaction small to gastrointestinal irritation is few.
According to the present invention, a kind of application of pharmaceutical preparation in the medicine for treating helicobacter pylori infections disease is prepared,
Application of the pharmaceutical preparation in the medicine for preparing treatment Stomach duodenum helicobacter pylori infections disease, eradicates stomach, ten
Helicobacter pylori in two duodenum 12, maximum is provided to utterly destroy mankind's Stomach duodenum helicobacter pylori infections disease
May, its feature or advantage are：
■ eradicates Stomach duodenum helicobacter pylori according to pharmaceutical preparation of the present invention, is to treat at present thoroughly completely
The best medicine of effect；
■, according to pharmaceutical preparation of the present invention, is that current only single drug just can effectively eradicate Stomach duodenum and imprison
The medicine of Helicobacter pylori；At present frequently with Multiple Classes of Antibiotics use in conjunction, serious adverse reaction can be caused；
According to pharmaceutical preparation of the present invention, orally, once a day, 3~5 days, be the most short medicine of the current course for the treatment of to ■, is used
Method is simple, and patient compliance is good；
The common antibiotics that ■ is usually used in eradicating at present Stomach duodenum helicobacter pylori almost do not have a kind of antibiotic not
There is bacterial resistance sex chromosome mosaicism；According to pharmaceutical preparation of the present invention, Stomach duodenum helicobacter pylori is eradicated, in the absence of thin
Bacterium drug resistance problems；
■ eradicates Stomach duodenum helicobacter pylori according to pharmaceutical preparation of the present invention, and adverse reaction is few, security
It is high；
■ eradicates Stomach duodenum helicobacter pylori at present frequently with Multiple Classes of Antibiotics use in conjunction, can cause enterobacteriaceae
Group lacks of proper care and causes serious adverse reaction；According to pharmaceutical preparation of the present invention, Stomach duodenum helicobacter pylori is eradicated,
Intestinal bacilli illness will not be caused and cause serious adverse reaction；
■ according to pharmaceutical preparation of the present invention, in the therapeutic process for eradicating Stomach duodenum helicobacter pylori, it is to avoid
The generation of the super drug-resistant bacteria of anti-medicine；Abuse of antibiotics can cause the generation of super drug-resistant bacteria, may cause the mankind
Bacterial infection disease is without the available crisis of medicine；
■ eradicates Stomach duodenum helicobacter pylori according to pharmaceutical preparation of the present invention, be thoroughly eliminate mankind's stomach,
Duodenum helicobacter pylori infections disease provides maximum possibility.
Specific embodiment
According to the present invention, a kind of application of pharmaceutical preparation in the medicine for treating helicobacter pylori infections disease is prepared,
The pharmaceutical preparation is a kind of pharmaceutical preparation containing elemental iodine or iodine compound, the medicine system containing elemental iodine or iodine compound
There is molecular iodine in the aqueous solution of agent, the pharmaceutical preparation containing elemental iodine or iodine compound is imprisoned in preparation treatment Stomach duodenum
Application in the medicine of Helicobacter pylori infectious diseases, eradicates Stomach duodenum helicobacter pylori, be containing elemental iodine or
Molecular iodine present in the aqueous solution of the pharmaceutical preparation of iodine compound, its molecular iodine be kill helicobacter pylori it is basic, must
The condition and main component wanted, i.e. as long as having molecular iodine in the aqueous solution of the pharmaceutical preparation containing elemental iodine or iodine compound
In the presence of, just will necessarily have kill helicobacter pylori effect, due to the water containing elemental iodine or the pharmaceutical preparation of iodine compound
The pharmaceutical preparation that there is molecular iodine in solution is numerous, be difficult to enumerate or implement one by one, thus specific embodiment only list with
Lower three.
In the embodiment of following three, using the most frequently used at present14C- urea breath tests, it is existing for helicobacter pylori
The diagnosis of disease infection and the judgement of Helicobacter pylori eradication for treatment effect, its result of the test is by Huaxi Hospital Attached to Sichuan Univ14C is imprisoned
Helicobacter pylori (HP) examining report is given.
Embodiment one：Volunteer trial person, man, adult, ordinary gastrocopy and biopsy diagnosis be moderate to severe atrophic gastritis,
Before eradication therapy,14C helicobacter pyloris examining report (2016-4-25 13：18：5)：DPM=2660 is positive++++；For eradicating
The pharmaceutical preparation of the helicobacter pylori in Stomach duodenum is the aqueous solution pharmaceutical preparation of iodamylum, KI and water composition, mouth
Clothes, each 50ml, 3mg containing iodine, one time a day, takes medicine continuously 5, and morning administered at empty stomach is used；Have no that adverse reaction occurs during medication.In
After being discontinued 1 month14C helicobacter pyloris examining report (2016-6-20 13：17：5)：DPM=182 is positive+。
Conclusion：Experiment shows that the aqueous solution of the pharmaceutical preparation being made up of iodamylum, KI and water is used to eradicate stomach, 12
Duodenum 12 helicobacter pylori has significant curative effect；Adjustment dosage or the course for the treatment of, should obtain more preferable effect.
Embodiment two
The volunteer trial person of embodiment one, the aqueous solution for using the pharmaceutical preparation being made up of elemental iodine, KI instead eradicates stomach, ten
Two duodenum 12 helicobacter pyloris, orally, each 100ml, 15mg containing iodine, one time a day, takes medicine continuously 5, and morning administered at empty stomach is used；The medication phase
Between and the long period after being discontinued have a stomach upset, the significant adverse reaction such as abdominal pain, Nausea and vomiting.Elimination is controlled
Before treatment14C helicobacter pyloris examining report (2016-6-20 13：17：5)：DPM=182 is positive+；After being discontinued 1 month14C is imprisoned
Helicobacter pylori examining report (2016-8-8 10：10：02)：：DPM=0, it is negative-。
Conclusion：Experiment shows that the aqueous solution of the pharmaceutical preparation being made up of elemental iodine, KI is used to eradicate Stomach duodenum
Helicobacter pylori has the curative effect of highly significant；But there is significant adverse reaction.
Embodiment three
Volunteer trial person, female, adult, gastroscopy is diagnosed as chronic non-atrophic gastritis, before eradication therapy14C is imprisoned
Helicobacter pylori examining report (2016-5-13 11：18：5)：DPM=490 is positive+。
Patient is treated by the Conventional treatment regimens for eradicating the helicobacter pylori in Stomach duodenum at present, Pariet
4 kinds of combination therapies such as 10mg, bismuth potassium citrate 440mg, Imacil 1000mg and CLA 500mg, orally, 2 times a day,
It is used in conjunction 14 days；There is the significant adverse reaction such as Nausea and vomiting during medication.
After being discontinued 1 month14C helicobacter pyloris examining report (2016-6-20 13：20：3)：DPM=245 is positive+；
Treatment results show that the helicobacter pylori in Stomach duodenum is not eradicated entirely.
Use the aqueous solution of the pharmaceutical preparation being made up of elemental iodine, KI instead, orally, each 100ml, 3mg containing iodine, daily
1 time, 5 are taken medicine continuously, morning administered at empty stomach is used；During medication and be discontinued after long period have a stomach upset, abdominal pain, nausea,
The adverse reactions such as vomiting occur.
After being discontinued 1 month14C helicobacter pyloris examining report (2016-11-8 13：42：3)：DPM=0, it is negative.
Conclusion：Experiment shows that the pharmaceutical preparation being made up of the aqueous solution of elemental iodine is used to eradicate Stomach duodenum pylorus spiral shell
Bacillus has the curative effect of highly significant；But there is more significant adverse reaction.
Present specification is only used for application for a patent for invention, rather than medical treatment guidance file.Embodiment described in present specification
In volunteer trial person, be researcher of the present invention, it is known that the risk that exists and the Disposal Measures that should possess.In embodiment
Medicine used, medication purpose and administrated method, are not that teaching people use same medicine because of same medication purpose
And use same administrated method；In embodiment there is greater risk in medicine used, medication purpose and administrated method, earnestly not
Can copy.
Claims (10)
1. application of a kind of pharmaceutical preparation in the medicine for preparing treatment helicobacter pylori infections disease, it is characterised in that：Institute
It is a kind of pharmaceutical preparation containing elemental iodine or iodine compound, the pharmaceutical preparation containing elemental iodine or iodine compound to state pharmaceutical preparation
The aqueous solution in there is molecular iodine, the pharmaceutical preparation containing elemental iodine or iodine compound prepare treatment Stomach duodenum pylorus
Application in the medicine of pylori (Hp) infection disease, eradicates the helicobacter pylori in Stomach duodenum.
2. a kind of pharmaceutical preparation according to claim 1 is in the medicine for preparing treatment helicobacter pylori infections disease
Using, it is characterised in that：The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine, the medicine system being made up of elemental iodine
There is molecular iodine in the aqueous solution of agent, the pharmaceutical preparation being made up of elemental iodine is preparing treatment Stomach duodenum helicobacter pylori
Application in the medicine of infectious diseases, eradicates the helicobacter pylori in Stomach duodenum.
3. a kind of pharmaceutical preparation according to claim 1 is in the medicine for preparing treatment helicobacter pylori infections disease
Using, it is characterised in that：The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine and water, is made up of elemental iodine and water
Pharmaceutical preparation the aqueous solution in there is molecular iodine, the pharmaceutical preparation being made up of elemental iodine and water is preparing treatment stomach, 12 fingers
Application in the medicine of intestines helicobacter pylori infections disease, eradicates the helicobacter pylori in Stomach duodenum.
4. a kind of pharmaceutical preparation according to Claims 2 or 3 is preparing the medicine for the treatment of helicobacter pylori infections disease
In application, it is characterised in that：The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine or by elemental iodine and water group
Into pharmaceutical preparation, deposited in the aqueous solution of the pharmaceutical preparation being made up of elemental iodine or the pharmaceutical preparation being made up of elemental iodine and water
The concentration of iodine is 1~30mg/100ml, the pharmaceutical preparation being made up of elemental iodine or by elemental iodine and water in molecular iodine, the aqueous solution
Application of the pharmaceutical preparation of composition in the medicine for preparing treatment Stomach duodenum helicobacter pylori infections disease, elimination stomach,
ID helicobacter pylori.
5. a kind of pharmaceutical preparation according to Claims 2 or 3 is preparing the medicine for the treatment of helicobacter pylori infections disease
In application, it is characterised in that：The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine or by elemental iodine and water group
Into pharmaceutical preparation, deposited in the aqueous solution of the pharmaceutical preparation being made up of elemental iodine or the pharmaceutical preparation being made up of elemental iodine and water
The concentration of iodine is 2~10mg/100ml, the pharmaceutical preparation being made up of elemental iodine or by elemental iodine and water in molecular iodine, the aqueous solution
Application of the pharmaceutical preparation of composition in the medicine for preparing treatment Stomach duodenum helicobacter pylori infections disease, elimination stomach,
ID helicobacter pylori.
6. a kind of pharmaceutical preparation according to Claims 2 or 3 is preparing the medicine for the treatment of helicobacter pylori infections disease
In application, it is characterised in that：The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine or by elemental iodine and water group
Into pharmaceutical preparation, deposited in the aqueous solution of the pharmaceutical preparation being made up of elemental iodine or the pharmaceutical preparation being made up of elemental iodine and water
The concentration of iodine is 3~8mg/100ml, the pharmaceutical preparation being made up of elemental iodine or by elemental iodine and water in molecular iodine, the aqueous solution
Application of the pharmaceutical preparation of composition in the medicine for preparing treatment Stomach duodenum helicobacter pylori infections disease, elimination stomach,
ID helicobacter pylori.
7. a kind of pharmaceutical preparation according to Claims 2 or 3 is preparing the medicine for the treatment of helicobacter pylori infections disease
In application, it is characterised in that：The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine or by elemental iodine and water group
Into pharmaceutical preparation, deposited in the aqueous solution of the pharmaceutical preparation being made up of elemental iodine or the pharmaceutical preparation being made up of elemental iodine and water
The concentration of iodine is 4~6mg/100ml, the pharmaceutical preparation being made up of elemental iodine or by elemental iodine and water in molecular iodine, the aqueous solution
Application of the pharmaceutical preparation of composition in the medicine for preparing treatment Stomach duodenum helicobacter pylori infections disease, elimination stomach,
ID helicobacter pylori.
8. a kind of pharmaceutical preparation according to Claims 2 or 3 is preparing the medicine for the treatment of helicobacter pylori infections disease
In application, it is characterised in that：The pharmaceutical preparation is a kind of pharmaceutical preparation being made up of elemental iodine or by elemental iodine and water group
Into pharmaceutical preparation, deposited in the aqueous solution of the pharmaceutical preparation being made up of elemental iodine or the pharmaceutical preparation being made up of elemental iodine and water
The concentration of iodine is 5mg/100ml in molecular iodine, the aqueous solution, the pharmaceutical preparation being made up of elemental iodine or is made up of elemental iodine and water
Pharmaceutical preparation prepare treatment Stomach duodenum helicobacter pylori infections disease medicine in application, eradicate stomach, 12
Helicobacter pylori in duodenum 12.
9. a kind of pharmaceutical preparation according to claim 1 is in the medicine for preparing treatment helicobacter pylori infections disease
Using, it is characterised in that：The iodine compound be it is a kind of in aqueous, become in the chemistry for dissociation occurring and produce molecular iodine
Before change, it is impossible to directly absorbed by alimentary canal and the iodine compound of entrance blood circulation；Containing in aqueous, occur dissociation,
And before producing the chemical change of molecular iodine, it is impossible to directly absorbed by alimentary canal and the medicine system of the iodine compound of entrance blood circulation
Application of the agent in the medicine for preparing treatment Stomach duodenum helicobacter pylori infections disease, eradicates in Stomach duodenum
Helicobacter pylori.
10. a kind of pharmaceutical preparation according to claim 1 or 9 is preparing the medicine for the treatment of helicobacter pylori infections disease
In application, it is characterised in that：The iodine compound is iodamylum, exists in the aqueous solution of the pharmaceutical preparation containing iodamylum and divides
Sub- iodine, the pharmaceutical preparation containing iodamylum is in the medicine for preparing treatment Stomach duodenum helicobacter pylori infections disease
Using the helicobacter pylori in elimination Stomach duodenum.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611203590.3A CN106727683A (en) | 2016-12-23 | 2016-12-23 | A kind of application of pharmaceutical preparation in the medicine for preparing treatment helicobacter pylori infections disease |
| PCT/CN2017/000733 WO2018113042A1 (en) | 2016-12-23 | 2017-12-12 | Use of pharmaceutical preparation in preparation of medicine for treating helicobacter pylori infectious disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611203590.3A CN106727683A (en) | 2016-12-23 | 2016-12-23 | A kind of application of pharmaceutical preparation in the medicine for preparing treatment helicobacter pylori infections disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106727683A true CN106727683A (en) | 2017-05-31 |
Family
ID=58899969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611203590.3A Pending CN106727683A (en) | 2016-12-23 | 2016-12-23 | A kind of application of pharmaceutical preparation in the medicine for preparing treatment helicobacter pylori infections disease |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN106727683A (en) |
| WO (1) | WO2018113042A1 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1065201A (en) * | 1992-04-30 | 1992-10-14 | 吴泰相 | Full-element health-care toothpaste |
| CN104381786A (en) * | 2014-10-29 | 2015-03-04 | 胡安然 | All-nutrition formula food with function of eliminating helicobacter pylori |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5885592A (en) * | 1997-10-29 | 1999-03-23 | Symbollon Corporation | Methods and pharmaceutical compositions for oral delivery of molecular iodine |
-
2016
- 2016-12-23 CN CN201611203590.3A patent/CN106727683A/en active Pending
-
2017
- 2017-12-12 WO PCT/CN2017/000733 patent/WO2018113042A1/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1065201A (en) * | 1992-04-30 | 1992-10-14 | 吴泰相 | Full-element health-care toothpaste |
| CN104381786A (en) * | 2014-10-29 | 2015-03-04 | 胡安然 | All-nutrition formula food with function of eliminating helicobacter pylori |
Non-Patent Citations (2)
| Title |
|---|
| 李开顺: "胶质次枸椽酸铋与碘化钠联用根除幽门螺杆菌", 《国外医学情报》 * |
| 汤文俊等: "胃癌和甲状腺疾病相关性研究进展", 《生命科学》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018113042A1 (en) | 2018-06-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5819909B2 (en) | Homeopathic preparation | |
| CN101041009A (en) | Chinese traditional medicine compound for treating faucitis | |
| TWI316405B (en) | A pharmaceutical composition for reducing pain in a mammal suffering from a neoplasm | |
| CN106727683A (en) | A kind of application of pharmaceutical preparation in the medicine for preparing treatment helicobacter pylori infections disease | |
| CN104523897A (en) | Enteroclysis medicine composition for treating piglet epidemic diarrhea | |
| CN101337020B (en) | Traditional Chinese medicine composition for preventing frog gastroenteritis and hemorrhagic disease | |
| CN102726624A (en) | Traditional Chinese medicine feed additive for controlling pig clostridial enteritis | |
| RU2199336C1 (en) | Biologically active substance | |
| CN106539822A (en) | Florfenicol powder and preparation method thereof | |
| TWI843562B (en) | Use of extract of cynara scolymus for manufacturing medicationfor treatment of alzheimer's disease | |
| CN1331530C (en) | Medicinal preparation for treating stomach and intestine diseases and its preparing method | |
| RU2185838C2 (en) | Method for prophylaxis of colibacteriosis in calves | |
| CN105343454A (en) | Traditional Chinese medicinal capsule for treating thrombus, and preparation method thereof | |
| WO2021187635A1 (en) | Production of mixture for preventing and treating respiratory infectious diseases and viral pneumonia | |
| Sircus | Sodium Bicarbonate: Nature's Unique First Aid Remedy | |
| CN104069473B (en) | A kind of Chinese medicine composition for the treatment of bacterial enteritis and preparation method thereof | |
| CN119235947A (en) | A plant extract for inhibiting Helicobacter pylori and its preparation method and application | |
| CN104906577B (en) | A kind of pharmaceutical composition for eradicating helicobacter pylori and preparation method thereof | |
| CN117045691A (en) | Application of Hemsleya amabilis extract in resisting helicobacter pylori | |
| CN102961361A (en) | Medicinal composition containing Cefcapene pivoxil and capsule preparation method thereof | |
| RU2283120C1 (en) | Method for treating intestinal dysbacteriosis in peritonitis cases | |
| RU2239425C1 (en) | Method for treating colibacteriosis and salmonellosis in piglets | |
| Piberl | ZEOLITE | |
| CN102727613A (en) | External medicinal liquor for controlling pig sarcoptidosis, and preparation method thereof | |
| CN105343470A (en) | Traditional Chinese medicine composition for treating mouth floor cellulitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |