CN106727449A - A kind of Xylitol nicotinamide spray and preparation method thereof - Google Patents
A kind of Xylitol nicotinamide spray and preparation method thereof Download PDFInfo
- Publication number
- CN106727449A CN106727449A CN201611184947.8A CN201611184947A CN106727449A CN 106727449 A CN106727449 A CN 106727449A CN 201611184947 A CN201611184947 A CN 201611184947A CN 106727449 A CN106727449 A CN 106727449A
- Authority
- CN
- China
- Prior art keywords
- spray
- xylitol
- nicotinamide
- nicotine
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of Xylitol nicotinamide spray and preparation method thereof, belong to MC spray field.The spray includes xylitol, nicotine, vitamin C.Xylitol nicotinamide spray of the present invention can provide the satisfaction that smoking population is equal to smoking, while having functions that anti-inflammatory, oral health again.
Description
Technical field
The present invention relates to a kind of Xylitol nicotinamide spray and preparation method thereof, belong to MC spray field.
Background technology
Harm of the smoking to body is it is well known that the relevant disease that smoking triggers has turned into primarily asking for human health
Topic, national governments are further strict for the limitation of smoking especially public place smoking, and smoking cessation has become guarantee personal health,
Improve the important measure of PE simultaneously.
The content of the invention
The present invention, as the substitute of tobacco of smoking population, solves the problem of above-mentioned smoking cessation by nicotine, meanwhile, this hair
It is bright that vitamin C is also cooperateed with using xylitol, strengthen the effect in its health care oral cavity.
The invention provides a kind of Xylitol nicotinamide spray, the spray includes xylitol, nicotine, vitamin C.
The present invention cooperates with the metabolism of vitamin C, xylitol not need insulin to participate in using xylitol, and vitamin C promotes
The discharge of harmful substance in smoker's body, not only increases the effect of its oral health and enhance immunity, also meets difference
The smoking cessation of crowd needs.
Spray of the present invention is preferably, by weight, composed of the following components：
Xylitol 20-30 parts
Nicotine 0.5-3 parts
Vitamin C 0.01-0.5 parts.
Spray of the present invention preferably comprises xylitol, glycerine, ethanol, nicotine, polysorbas20, vitamin C, water.
Water of the present invention is preferably pure water.
Spray of the present invention is preferably, by weight, composed of the following components：
Spray of the present invention preferably comprises xylitol, glycerine, ethanol, nicotine, polysorbas20, vitamin C, citric acid
Sodium, citric acid, essence, water.
The present invention is using citric acid with sodium citrate as the buffer in system, it is ensured that the stability of nicotine.
Spray of the present invention is preferably, by weight, composed of the following components：
Another object of the present invention is to provide a kind of preparation method of above-mentioned spray, and the preparation method comprises the following steps：
1. predetermined weight part is pressed, said components are taken；
2. it is xylitol, sodium citrate and vitamin C is soluble in water, obtain solution I；
3. essence and glycerine are dissolved in ethanol, obtain solution II；
4. solution I is mixed with solution II, adds polysorbas20 to solution to clarify, add nicotine, adjusted by citric acid
PH value obtains Xylitol nicotinamide spray to 8-9.
The present invention has the beneficial effect that：
1. Xylitol nicotinamide spray of the present invention can provide smoking population and be equal to the satisfaction of smoking, while have again
There are anti-inflammatory, oral health.
2. the pH value of Xylitol nicotinamide spray of the present invention is 8-9, makes nicotine be easier to be absorbed by the body.
3. Xylitol nicotinamide spray of the present invention environmental protection, health.
Specific embodiment
Following non-limiting examples can make one of ordinary skill in the art be more fully understood the present invention, but not with
Any mode limits the present invention.
Embodiment 1
A kind of preparation method of Xylitol nicotinamide spray, the preparation method comprises the following steps：
1. 20 parts of xylitols, 2 parts of sodium citrates, 0.05 part of vitamin C are added sequentially in 59.32 parts of pure water, are obtained
To solution I；
2. 0.5 part of essence, 12 parts of glycerine are added in 5 parts of ethanol, obtain solution II；
3. solution I is mixed with solution II, adds 0.4 part of polysorbas20 to solution to clarify, add 0.63 part of nicotine, passed through
0.1 part of lemon acid for adjusting pH value obtains Xylitol nicotinamide spray to 8.3.
Embodiment 2
A kind of preparation method of Xylitol nicotinamide spray, the preparation method comprises the following steps：
1. 20 parts of xylitols, 2 parts of sodium citrates, 0.05 part of vitamin C are added sequentially in 58.7 parts of pure water, are obtained
Solution I；
2. 0.5 part of essence, 12 parts of glycerine are added in 5 parts of ethanol, obtain solution II；
3. solution I is mixed with solution II, adds 0.4 part of polysorbas20 to solution to clarify, add 1.25 parts of nicotine, passed through
0.1 part of lemon acid for adjusting pH value obtains Xylitol nicotinamide spray to 8.6.
Embodiment 3
A kind of preparation method of Xylitol nicotinamide spray, the preparation method comprises the following steps：
1. 20 parts of xylitols, 2 parts of sodium citrates, 0.05 part of vitamin C are added sequentially in 57.35 parts of pure water, are obtained
To solution I；
2. 0.5 part of essence, 12 parts of glycerine are added in 5 parts of ethanol, obtain solution II；
3. solution I is mixed with solution II, adds 0.4 part of polysorbas20 to solution to clarify, add 2.5 parts of nicotine, passed through
0.2 part of lemon acid for adjusting pH value obtains Xylitol nicotinamide spray to 8.7.
The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto,
Any one skilled in the art in the technical scope of present disclosure, technology according to the present invention scheme and its
Inventive concept is subject to equivalent or change, should all be included within the scope of the present invention.
Claims (7)
1. a kind of Xylitol nicotinamide spray, it is characterised in that：The spray includes xylitol, nicotine, vitamin C.
2. spray according to claim 1, it is characterised in that：The spray, it is by weight, composed of the following components：
Xylitol 20-30 parts
Nicotine 0.5-3 parts
Vitamin C 0.01-0.5 parts.
3. spray according to claim 1, it is characterised in that：The spray includes xylitol, glycerine, ethanol, nicotine, tells
Temperature 20, vitamin C, water.
4. spray according to claim 3, it is characterised in that：The spray, it is by weight, composed of the following components：
5. spray according to claim 1, it is characterised in that：The spray includes xylitol, glycerine, ethanol, nicotine, tells
Temperature 20, vitamin C, sodium citrate, citric acid, essence, water.
6. spray according to claim 5, it is characterised in that：The spray, it is by weight, composed of the following components：
7. the preparation method of spray described in claim 1,2,3,4,5 or 6, it is characterised in that：The preparation method includes as follows
Step：
1. predetermined weight part is pressed, said components are taken；
2. it is xylitol, sodium citrate and vitamin C is soluble in water, obtain solution I；
3. essence and glycerine are dissolved in ethanol, obtain solution II；
4. solution I is mixed with solution II, adds polysorbas20 to solution to clarify, nicotine is added, by lemon acid for adjusting pH value
To 8-9, Xylitol nicotinamide spray is obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611184947.8A CN106727449A (en) | 2016-12-20 | 2016-12-20 | A kind of Xylitol nicotinamide spray and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611184947.8A CN106727449A (en) | 2016-12-20 | 2016-12-20 | A kind of Xylitol nicotinamide spray and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106727449A true CN106727449A (en) | 2017-05-31 |
Family
ID=58894116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611184947.8A Pending CN106727449A (en) | 2016-12-20 | 2016-12-20 | A kind of Xylitol nicotinamide spray and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106727449A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107260682A (en) * | 2017-06-01 | 2017-10-20 | 防城港圣保堂制药有限公司 | A kind of ion VC powder sprays and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1607950A (en) * | 2001-12-27 | 2005-04-20 | 法马西雅公司 | A liquid pharmaceutical formulation comprising nicotine for the administration to the oral cavity |
-
2016
- 2016-12-20 CN CN201611184947.8A patent/CN106727449A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1607950A (en) * | 2001-12-27 | 2005-04-20 | 法马西雅公司 | A liquid pharmaceutical formulation comprising nicotine for the administration to the oral cavity |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107260682A (en) * | 2017-06-01 | 2017-10-20 | 防城港圣保堂制药有限公司 | A kind of ion VC powder sprays and preparation method thereof |
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| Date | Code | Title | Description |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170531 |