CN106726035A - Degradable magnesium alloy Esophageal Stent and preparation method thereof - Google Patents
Degradable magnesium alloy Esophageal Stent and preparation method thereof Download PDFInfo
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- CN106726035A CN106726035A CN201611260980.4A CN201611260980A CN106726035A CN 106726035 A CN106726035 A CN 106726035A CN 201611260980 A CN201611260980 A CN 201611260980A CN 106726035 A CN106726035 A CN 106726035A
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- magnesium alloy
- alloy
- esophageal stent
- degradable
- alloy wire
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- 229910000861 Mg alloy Inorganic materials 0.000 title claims abstract description 101
- 238000002360 preparation method Methods 0.000 title claims description 6
- 239000003814 drug Substances 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 17
- 229940079593 drug Drugs 0.000 claims description 15
- 239000011575 calcium Substances 0.000 claims description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 7
- 229910052791 calcium Inorganic materials 0.000 claims description 7
- 239000011248 coating agent Substances 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 7
- CADZRPOVAQTAME-UHFFFAOYSA-L calcium;hydroxy phosphate Chemical compound [Ca+2].OOP([O-])([O-])=O CADZRPOVAQTAME-UHFFFAOYSA-L 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 3
- 239000001506 calcium phosphate Substances 0.000 claims description 3
- 235000011010 calcium phosphates Nutrition 0.000 claims description 3
- 238000004070 electrodeposition Methods 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 150000002500 ions Chemical class 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 3
- 238000005253 cladding Methods 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 5
- 239000011777 magnesium Substances 0.000 description 5
- 229910052749 magnesium Inorganic materials 0.000 description 5
- 230000003211 malignant effect Effects 0.000 description 4
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 3
- 208000031481 Pathologic Constriction Diseases 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 238000009954 braiding Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- VDIQGOWLVYFDOU-UHFFFAOYSA-H [Ca+]O.[Ca+]O.[Ca+]O.[O-]P([O-])([O-])=O Chemical compound [Ca+]O.[Ca+]O.[Ca+]O.[O-]P([O-])([O-])=O VDIQGOWLVYFDOU-UHFFFAOYSA-H 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical group [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- MPNNOLHYOHFJKL-UHFFFAOYSA-N peroxyphosphoric acid Chemical compound OOP(O)(O)=O MPNNOLHYOHFJKL-UHFFFAOYSA-N 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
- A61F2240/002—Designing or making customized prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a kind of degradable magnesium alloy Esophageal Stent, it is characterized in that, including Mg alloy wire, Mg alloy wire is woven into the Esophageal Stent of net tubular.The present invention is rational in infrastructure, easy to use.The degradable magnesium alloy Esophageal Stent for meeting use requirement can fast and effectively be prepared.
Description
Technical field：
The present invention relates to a kind of degradable magnesium alloy Esophageal Stent and preparation method thereof.
Background technology：
Esophageal benign and malignant danger, malignant stricture are one of significant clinical problems that digestive endoscopy doctor needs solution.For esophageal benign and malignant
Property and malignant stricture, treatment method conventional at present includes that lemostenosis is expanded or esophageal stenting.In lemostenosis
Treatment aspect, conventional support is Nitinol self-inflated metallic support.For the patient of stricture of esophageal anastomosis, support is planted
Enter rear 4-12 month, can be formed because tumor or granulation tissue hyperplasia cause to be blocked in support by mesh to growth in support
It is narrow again, cause patient's dysphagia aggravate in addition cause perforation etc. complication, it is necessary to second operation take out, this adds increased
The pain of patient, Operative risk and medical expense.
The content of the invention：
To solve the deficiency in above-mentioned technical problem, it is an object of the present invention to provide one kind can overcome drawbacks described above,
Meet degradable magnesium alloy Esophageal Stent of use demand and preparation method thereof.
A kind of degradable magnesium alloy Esophageal Stent provided by the present invention, it is characterized in that, including Mg alloy wire, Mg alloy wire
It is woven into the Esophageal Stent of net tubular.
Preferably, there is di calcium layer outside described Mg alloy wire.
It is further preferred that having medication coat outside described di calcium layer.
Preferably, described Mg alloy wire is coated with magnesium alloy film.
It is further preferred that described magnesium alloy film is coated with medication coat.
Preferably, described Mg alloy wire is rolled by magnesium alloy thin slice and is extruded from, in magnesium alloy thin slice intermediate pressure system one
Bar or a plurality of groove, are placed with medicine in groove.
A kind of degradable magnesium alloy Esophageal Stent preparation method, it is characterized in that, including the one kind in following three in method：
The step of method 1, is as follows：
(1) medical magnesium alloy is drawn into Mg alloy wire, a diameter of 0.1-3mm；
(2) Mg alloy wire is put into and contains Ca2+、Mg2+And H2PO4 -The aqueous solution in, ion can effectively with Mg2+Occur
Reaction, forms calcium hydroxy phosphate, and calcium hydroxyl phosphate coating is formed after drying；Or generated in Mg alloy surface using electrodeposition process
Calcium hydroxyl phosphate coating；
(3) Mg alloy wire is woven into degradable magnesium alloy Esophageal Stent；
(4) degradable magnesium alloy Esophageal Stent is put into drug solution and is soaked or spraying medicine, then dried, obtained into
Product.
The step of method 2, is as follows：
(1) medical magnesium alloy is drawn into Mg alloy wire and magnesium alloy film；
(2) medicine is adhered on the one side of magnesium alloy film；
(3) the magnesium alloy film of good attachment medicine is coated on Mg alloy wire, the load powder of film is inwardly；
(4) it is woven into degradable magnesium alloy Esophageal Stent；
The step of method 3, is as follows：
(1) medical magnesium alloy is made magnesium alloy thin slice, thickness is 0.5mm-2mm；
(2) thin slice is cut into slice, width is between 0.1-3mm；
(3) one or more groove is suppressed in the middle of slice, medicine is prevented in groove；
(4) magnesium alloy is rolled and is extruded, form the Mg alloy wire of interior drug containing；
(5) Mg alloy wire of interior drug containing is woven into degradable magnesium alloy Esophageal Stent.
The beneficial effects of the invention are as follows：
It is rational in infrastructure, it is easy to use.The degradable magnesium alloy Esophageal Stent for meeting use requirement can fast and effectively be prepared.
And in vivo once degrading, its supporting role is gradually reduced degradable magnesium alloy, and certain hour is that degraded is finished and discharges body
Outward.Need not scope intervention again after inserting, it is to avoid second operation takes out, implantation is repeated, before wide clinical practice
Scape.
Magnesium is nutrient needed by human, is constituted together with sodium, potassium, calcium constituent most important 4 kinds inside and outside human body cell
Cation.Magnesium is the activator and confactor of various enzymes.Magnesium is the important component of bone and tooth, and prevention sclerotin is dredged
Pine has certain effect.For human recycle system, magnesium can cause blood vessel dilatation, while there is the work of atherosclerosis
With.Magnesium participates in internal three big heat production nutrientses metabolism, nerve impulse and produces with transmission, contraction of muscle etc..The degraded of magnesium alloy is right
Human body is comparatively safe.
Brief description of the drawings
Below in conjunction with the accompanying drawings and implementation method the present invention is further detailed explanation：
Fig. 1-Fig. 5 is schematic structural view of the invention；
In figure, 1, Esophageal Stent.
Specific embodiment
Degradable magnesium alloy Esophageal Stent as Figure 1-5 includes Mg alloy wire, and Mg alloy wire is woven into net tubular
Esophageal Stent 1.
Embodiment 1：
There is di calcium layer outside described Mg alloy wire.It is further preferred that having outside described di calcium layer
Medication coat.
Medical magnesium alloy is drawn into silk, be put into for Mg alloy wire and contain Ca by diameter between 0.1-3mm2+、Mg2+With
H2PO4 -The aqueous solution in, ion can effectively with Mg2+React, form calcium hydroxy phosphate, low temperature, low pressure drying form hydroxyl
Base calcium phosphate coating.Calcium hydroxyl phosphate coating can also be generated in Mg alloy surface using electrodeposition process.
Then degradable magnesium alloy Esophageal Stent of different shapes is woven into the Mg alloy wire of hydroxyl calcium phosphate coating,
There are the different models such as single trumpet type, double trumpet type, wine glass-shaped, wineglass bulb-shaped, mushroom bulb-shaped.
Such as need to increase medication coat, trachea bracket can be put into drug solution and soaked, then low temperature, low pressure drying, or
Spraying medicine, low temperature, low pressure drying.
When using, by the compression of degradable magnesium alloy Esophageal Stent, when putting into lemostenosis position, being expanded by air bag will
Support restores to the original state.
Implementation method 2：
Magnesium alloy is made film and silk, then film is covered magnesium alloy by the medicine in attachment on magnesium alloy film
On silk (the load powder of film is inwardly), process under cryogenic, load medicine film is tightly combined with Mg alloy wire.By film
Thickness it is different, process different Mg alloy wires, weave a support with different types of Mg alloy wire, it was being degraded
Medicine can discharge in the different time in journey, reach the purpose of continuous release.The support of braiding have single trumpet type, double trumpet type,
The different models such as wine glass-shaped, wineglass bulb-shaped, mushroom bulb-shaped.
When using, by the compression of degradable magnesium alloy Esophageal Stent, when putting into lemostenosis position, being expanded by air bag will
Support restores to the original state.
Implementation method 3：
Magnesium alloy is made magnesium alloy thin slice (thickness is between 0.05-2mm), cut into slice (width 0.1-3mm it
Between), in one or several groove of intermediate pressure, magnesium alloy bar is rolled and extruded by holding medicine in groove under low temperature, makes pastille
Thing Mg alloy wire.The Mg alloy wire of drug containing is woven into support net, the support of braiding has single trumpet type, double trumpet type, wineglass
The different models such as type, wineglass bulb-shaped, mushroom bulb-shaped.
When using, by the compression of degradable magnesium alloy Esophageal Stent, when putting into lemostenosis position, being expanded by air bag will
Support restores to the original state.
It is clear example of the present invention that above-mentioned case study on implementation is only, and is not the limit to embodiment of the present invention
It is fixed.To belonging to the obvious change or change still in protection scope of the present invention that spirit of the invention amplifies out.
Claims (7)
1. a kind of degradable magnesium alloy Esophageal Stent, it is characterized in that, including Mg alloy wire, Mg alloy wire is woven into the food of net tubular
Pipe holder.
2. degradable magnesium alloy Esophageal Stent according to claim 1, it is characterized in that, there is hydroxyl outside described Mg alloy wire
Calcium phosphate.
3. degradable magnesium alloy Esophageal Stent according to claim 2, it is characterized in that, described di calcium layer is outer attached
There is medication coat.
4. degradable magnesium alloy Esophageal Stent according to claim 1, it is characterized in that, described Mg alloy wire is coated with
Magnesium alloy film.
5. degradable magnesium alloy Esophageal Stent according to claim 4, it is characterized in that, described magnesium alloy film outer cladding
There is medication coat.
6. degradable magnesium alloy Esophageal Stent according to claim 1, it is characterized in that, described Mg alloy wire is by magnesium alloy
Thin slice is rolled and is extruded from, and in the groove of magnesium alloy thin slice intermediate pressure system one or more, medicine is placed with groove.
7. a kind of degradable magnesium alloy Esophageal Stent preparation method, it is characterized in that, including the one kind in following three in method：
The step of method 1, is as follows：
(1) medical magnesium alloy is drawn into Mg alloy wire, a diameter of 0.1-3mm；
(2) Mg alloy wire is put into and contains Ca2+、Mg2+And H2PO4 -The aqueous solution in, ion can effectively with Mg2+React,
Calcium hydroxy phosphate is formed, calcium hydroxyl phosphate coating is formed after drying；Or hydroxyl is generated in Mg alloy surface using electrodeposition process
Calcium phosphate coating；
(3) Mg alloy wire is woven into degradable magnesium alloy Esophageal Stent；
(4) degradable magnesium alloy Esophageal Stent is put into drug solution and is soaked or spraying medicine, then dried, obtain finished product.
The step of method 2, is as follows：
(1) medical magnesium alloy is drawn into Mg alloy wire and magnesium alloy film；
(2) medicine is adhered on the one side of magnesium alloy film；
(3) the magnesium alloy film of good attachment medicine is coated on Mg alloy wire, the load powder of film is inwardly；
(4) it is woven into degradable magnesium alloy Esophageal Stent；
The step of method 3, is as follows：
(1) medical magnesium alloy is made magnesium alloy thin slice, thickness is 0.5mm-2mm；
(2) thin slice is cut into slice, width is between 0.1-3mm；
(3) one or more groove is suppressed in the middle of slice, medicine is prevented in groove；
(4) magnesium alloy is rolled and is extruded, form the Mg alloy wire of interior drug containing；
(5) Mg alloy wire of interior drug containing is woven into degradable magnesium alloy Esophageal Stent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611260980.4A CN106726035A (en) | 2016-12-30 | 2016-12-30 | Degradable magnesium alloy Esophageal Stent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611260980.4A CN106726035A (en) | 2016-12-30 | 2016-12-30 | Degradable magnesium alloy Esophageal Stent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106726035A true CN106726035A (en) | 2017-05-31 |
Family
ID=58953908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611260980.4A Pending CN106726035A (en) | 2016-12-30 | 2016-12-30 | Degradable magnesium alloy Esophageal Stent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106726035A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111544170A (en) * | 2020-05-13 | 2020-08-18 | 东华大学 | A non-slip and anti-stenosis esophageal stent with mesoporous structure |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015711A (en) * | 2007-02-07 | 2007-08-15 | 北京大学 | Medical implantation material capable of by degraded by body fluid and its preparing process |
| CN101385875A (en) * | 2007-09-12 | 2009-03-18 | 中国科学院金属研究所 | A fully degradable and absorbable drug slow-release magnesium alloy stent and its application |
| CN102309368A (en) * | 2010-07-09 | 2012-01-11 | 微创医疗器械(上海)有限公司 | Body lumen drug-carrying bracket and preparation method thereof |
| CN102772831A (en) * | 2012-08-20 | 2012-11-14 | 道淼科技(北京)有限公司 | Degradable drug loading stent |
| CN102908216A (en) * | 2012-10-30 | 2013-02-06 | 东南大学 | Biodegradable medical human body cavity channel inner bracket and preparation method thereof |
-
2016
- 2016-12-30 CN CN201611260980.4A patent/CN106726035A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015711A (en) * | 2007-02-07 | 2007-08-15 | 北京大学 | Medical implantation material capable of by degraded by body fluid and its preparing process |
| CN101385875A (en) * | 2007-09-12 | 2009-03-18 | 中国科学院金属研究所 | A fully degradable and absorbable drug slow-release magnesium alloy stent and its application |
| CN102309368A (en) * | 2010-07-09 | 2012-01-11 | 微创医疗器械(上海)有限公司 | Body lumen drug-carrying bracket and preparation method thereof |
| CN102772831A (en) * | 2012-08-20 | 2012-11-14 | 道淼科技(北京)有限公司 | Degradable drug loading stent |
| CN102908216A (en) * | 2012-10-30 | 2013-02-06 | 东南大学 | Biodegradable medical human body cavity channel inner bracket and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111544170A (en) * | 2020-05-13 | 2020-08-18 | 东华大学 | A non-slip and anti-stenosis esophageal stent with mesoporous structure |
| CN111544170B (en) * | 2020-05-13 | 2021-12-10 | 东华大学 | Anti-slip narrow-resistance esophageal stent with mesoporous structure |
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Application publication date: 20170531 |