CN106725283B - Portable xerophthalmia detector - Google Patents

Abstract

The invention discloses a portable dry eye syndrome detector, which comprises: a probe assembly, which includes an imaging assembly, an illumination light source, a camera module, a camera fixing device, a control board and a cover plate arranged in sequence; a handle, the first end of which is connected to the At the lower end of the probe assembly, the handle is configured as a bendable structure; a portable device, which includes a base, a head rest assembly, an adjustable handle bar and an adjustable workbench assembly; and an analysis device, which is integrated in a PC, and the The analysis device is connected in communication with the probe assembly, and the analysis device includes an image data acquisition unit, a data detection unit and a data analysis unit. The invention miniaturizes the probe assembly, makes the whole dry eye analysis device portable, and the probe assembly can be used independently as a hand-held device, occupies less space, is more convenient to use, and has stronger applicability.

Description

Portable dry eye tester

technical field

The invention relates to a dry eye detection device, in particular to a portable dry eye detection device.

Background technique

Dry eye refers to the general term for various diseases characterized by abnormal tear quality and quantity or dynamic abnormalities caused by any reason, accompanied by ocular discomfort, resulting in various diseases characterized by ocular surface tissue lesions. Conjunctival xerosis. Common symptoms include dry eyes, easy fatigue, itchy eyes, foreign body sensation, burning sensation, sticky secretions, fear of wind, photophobia, and sensitivity to external stimuli. A survey in the United States shows that 10%-15% of adults suffer from dry eye, 17% in Japan, 10.3% in Australia, and the prevalence of dry eye in my country is about 21%-33.7%. The incidence of dry eye is increasing year by year. With the widespread use of electronic screens, environmental degradation, abuse of eye drops, wearing of contact lenses and other reasons, dry eye will continue to increase. Clinicians urgently need a fast, portable , Non-contact, objective, quantitative, intelligent and comprehensive dry eye analysis equipment for auxiliary diagnosis. According to the pathological characteristics of dry eye, there are mainly two types of dry eye, including lipid-deficient dry eye (LTD) and water-deficient dry eye (ATD). The present invention can make a comprehensive analysis result on dry eye, assist physicians to formulate individualized treatment plans for different types and degrees of dry eye, improve treatment effect and reduce pain of patients.

Currently commonly used dry eye detection methods mainly include invasive tear film break-up time detection, tear secretion test (such as Schirmer I and II test), slit lamp examination and the recently launched German OCULUS Keratograph 5M, etc. The traditional tear film break-up time (BUT) test is the time when the first dry spot appears on the cornea under a slit lamp microscope after corneal fluorescein sodium staining. The accuracy of the test results depends on the experience of the observer and the effect of the stain on the tear film. Stability; tear secretion test uses standard test paper for tear measurement, gently put two standard test papers into the junction of the middle and outer 1/3 of the conjunctival sac under the test eye, the patient looks down or gently closes the eyes, and removes the test paper after 5 minutes , read the scale of the test paper after leaving it for one minute, and judge the diagnosis result according to the test value. This method can also test the basic value under the state of surface anesthesia of the patient, so as to avoid the tear secretion caused by the stimulation of the test paper itself from affecting the accuracy of the test result. The test method is also one of the commonly used methods in clinical ophthalmology at present. The cost is low, but the test process lasts for a long time, and the invasive method brings some discomfort to the patient; Keratograph5M can comprehensively analyze dry eye symptoms, but the equipment is relatively large , poor portability, high cost, and poor popularity.

The existing dry eye inspection method has the following disadvantages after analysis:

1. The method of observing the fluorescein-stained cornea based on the slit lamp depends on the experience of the physician and the stability of the dye to the tear film. The test results are highly subjective and unstable. Before the test, the patient needs to instill the dye. cause certain harm to patients;

2. The test method of tear secretion lasts for a long time, and the invasion of the test paper will bring some discomfort to the patient. The test result may be affected by the tear fluid stimulated by the test paper invasion, which will reduce the accuracy;

3. Keratograph 5M equipment is bulky and poor in portability;

4. Keratograph 5M is an integrated device, which is not suitable for the examination of lying patients;

5. The Keratograph 5M equipment structure is not compatible with the current ophthalmic examination equipment, and it takes up more space and resources.

Contents of the invention

Aiming at the above technical problems, the present invention discloses a portable dry eye detector, which includes a probe assembly composed of a high-resolution image acquisition module, an intelligent light source control module, a multifunctional ring light source module, and a dry eye comprehensive analysis software analysis module , handle and portable device, realize tear film break-up time statistical inspection, tear river height measurement, meibomian gland image acquisition enhancement and human eye lipid layer analysis and other functions, provide a basis for clinical dry eye diagnosis, suitable for clinical ophthalmology diagnosis and other functions Medical applications in related fields, at the same time, the probe assembly is miniaturized, and the entire dry eye analysis device is portable. The probe assembly can be used independently as a handheld device, which occupies less space, is more convenient to use, and has stronger applicability.

In order to realize these purposes and other advantages according to the present invention, a kind of portable dry eye syndrome detector is provided, comprising:

The probe assembly includes an imaging assembly, an illumination light source, a camera module, a camera fixing device, a control panel and a cover plate arranged in sequence, the imaging assembly is provided with an exit port, and the illumination light source and the camera assembly are respectively aligned with the outlet;

a handle, the first end of which is connected to the lower end of the probe assembly, and the handle is configured as a bendable structure;

Portable device, which includes a base, a headrest assembly, an adjustable handle bar and an adjustable workbench assembly, the bottom of the headrest assembly is fixed on the base, and the adjustable workbench assembly is movably installed on the On the base, the second end of the handle is detachably mounted on the adjustable workbench assembly; and

An analysis device, which is integrated in a PC, is communicatively connected to the probe assembly, and includes an image data acquisition unit, a data detection unit and a data analysis unit.

Preferably, the illumination light source is an LED ring light source, including a circuit substrate and near-infrared LEDs and white LEDs evenly arranged on the circuit substrate. The circuit substrate adopts a ring structure and an aluminum substrate material. Infrared LEDs and white light LEDs are arranged at intervals to form a ring light source structure. Several circles of evenly arranged near-infrared LEDs and white light LEDs are concentrically arranged on the circuit substrate. The near-infrared LEDs and white light LEDs are independently driven and have adjustable brightness.

Preferably, the imaging assembly includes a filter, a fixing sleeve, and a tapered tube, the fixing sleeve is configured as a light-gathering cavity structure, and the large opening of the light-gathering cavity is aligned with the exit surface of the illumination source, The optical filter is arranged on the light path between the illumination light source and the light-gathering cavity, the tapered cylinder is a Placido cone-shaped cylinder, and the tapered end of the cone-shaped cylinder is connected from the light-gathering cavity The small opening protrudes into the light concentrating cavity, and the flat bottom end of the tapered cylinder abuts against the small opening of the light concentrating cavity.

Preferably, the inner wall of the light-gathering cavity is coated with a diffuse reflection coating, and the outgoing light of the illumination source is uniformly reflected to the tapered surface of the tapered cylinder through the diffuse reflection coating.

Preferably, the camera module is a high-resolution color module, supports white light band imaging, 850nm near-infrared band imaging, supports autofocus, and the focus position is controllable, and the camera module is configured with multiple and different measurement modes The corresponding imaging mode, and the imaging mode of the camera module can be switched through the PC.

Preferably, the center of the circuit substrate, the filter, and the tapered cylinder are aligned with a through hole to form the exit port that emits light outward, and the exit port is aligned with the patient's eye.

Preferably, the camera fixing device is a cylindrical structure, and the front and rear sides of the camera fixing device are respectively provided with interconnected cavities, and the optical filter, the lighting source and the camera module are sequentially arranged on the In the front cavity, the large opening of the light-gathering cavity of the fixed sleeve is fixed outside the front cavity, the control board is arranged in the rear cavity, and is closed with the cover plate, and the control board input terminal is communicated with the PC through the serial port interface, the output terminal of the control board is connected with the illumination light source through the light source control module, and the camera module images the patient's eyes, and transmits the generated image to the The PC.

Preferably, the handle is a hollow structure, the connecting wire of the probe assembly passes through the handle and is connected to the analysis device, and the handle can be separated from the portable device to become an independent handheld analysis device; the head rest The assembly is arranged behind the probe assembly. Adjust the front, rear, left, and right distances of the adjustable workbench assembly and the probe assembly relative to the headrest assembly by swinging the adjustable hand lever, and adjust the lower jaw of the headrest assembly by rotating the adjustable hand lever up and down. The up and down position of the bracket relative to the probe assembly.

Preferably, the data detection unit includes a tear film breakup time inspection module, a tear river height measurement module, a meibomian gland image acquisition and enhancement module, and a lipid layer analysis module, and the data detection unit communicates with the image data acquisition unit The camera module is connected, the image data acquisition unit outputs eye images in real time through a video terminal, the output end of the data detection unit is connected to the data analysis unit, and the data analysis unit sends the detection report through the information management output unit output.

Preferably, the signal input end of the PC is provided with a tear film breakup time check button, a tear river height measurement button, a meibomian gland image acquisition and enhancement button, and a lipid layer analysis button, and each button corresponds to a corresponding measurement mode, Each measurement mode corresponds to an illumination mode and an imaging mode.

The present invention at least includes the following beneficial effects:

1. The measurement result of the device is accurate, objective and stable, the inspection time is short, and it can be quickly displayed on the video terminal;

2. The inspection process of the present invention is non-invasive, which reduces the pain of patients and reduces the difficulty of inspection;

3. The portable dry eye analysis device of the present invention has strong portability, ingenious design of lighting and imaging components, and the bottom structure is compatible with the structure of the slit lamp. When in use, it can be taken off as a handheld device for special patient examination, and it can also be used on the base of the slit lamp. One design and three usage methods are not only convenient for doctors to operate, but also save precious space resources in ophthalmology clinics to a certain extent;

4. The lighting source of the imaging system of the present invention is designed as a multi-mode LED ring light source, which provides a uniform, stable, and reliable infrared and white light lighting environment. The light source and brightness are adjustable, and the automatic switching of the dry eye inspection mode is realized;

5. The design of the imaging components of the device is compact, and the Placido cone design replaces the existing Placido ring design, which ensures the statistical accuracy of tear film breakup time and realizes the simplification of the Placido ring structure;

6. The design of the Placido cone can be removed during use to meet the needs of different imaging functions;

7. The dry eye comprehensive analysis software system completes the diagnostic analysis of four aspects of dry eye, including tear film break-up time inspection, tear river height measurement, meibomian gland image capture and enhancement, and lipid layer analysis.

Other advantages, objectives and features of the present invention will partly be embodied through the following descriptions, and partly will be understood by those skilled in the art through the study and practice of the present invention.

Description of drawings

Fig. 1 is the schematic diagram of the principle of detector of the present invention;

Fig. 2 is the structural representation of probe assembly;

Fig. 3 is a structural schematic diagram of an illumination light source;

Fig. 4 is a schematic structural diagram of a portable device.

Detailed ways

The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

It should be understood that terms such as "having", "comprising" and "including" as used herein do not entail the presence or addition of one or more other elements or combinations thereof.

The invention discloses a new portable dry eye detector, which includes a high-resolution image acquisition module, an intelligent light source control module, a probe assembly composed of a multifunctional annular light source module, a dry eye comprehensive analysis software analysis module, a handle and a portable The device realizes tear film break-up time statistical inspection, tear river height measurement, meibomian gland image acquisition enhancement and human eye lipid layer analysis and other functions, providing a basis for clinical dry eye diagnosis, suitable for clinical ophthalmology diagnosis and medical treatment in related fields At the same time, the probe assembly is miniaturized, and the entire dry eye analysis device is portable. The probe assembly can be used independently as a handheld device, which occupies less space, is more convenient to use, and has stronger applicability.

At present, the most commonly used examination methods for the clinical diagnosis of dry eye include corneal fluorescein staining, tear film break-up time measurement, tear secretion test, tear osmolarity, lactoferrin, tear fern test, rose bengal staining and questionnaire survey, etc. It mainly includes two types: intrusive and non-invasive. Among them, the invasive inspection method has a complicated operation process, a long inspection process cycle, and cumbersome procedures, and the inspection process relies on the subjective judgment of medical surveyors, which lacks specificity. At the same time, invasive inspection requires the cooperation of patients and affects patient comfort; The equipment can analyze dry eye medical records more comprehensively, but the equipment is relatively large, inconvenient to operate, and expensive, and it is not popularized in most hospitals in China.

Aiming at the above problems, the present invention proposes a new portable dry eye detector, which can measure tear film breakup time, tear river height, meibomian gland image capture and lipid layer analysis, high-resolution image The acquisition module and intelligent light source control module ensure clear measurement images and accurate measurement data, which in turn makes dry eye diagnosis easier and more objective. It is a non-invasive and repeatable dry eye inspection method. The structural design of the device is highly portable, and the bottom part of the probe assembly is compatible with the slit lamp instrument in the ophthalmology clinic, which is convenient for replacement and saves space resources in the clinic.

Embodiment one

As shown in Figure 1, it is an implementation form according to the present invention, which includes: a probe assembly for taking pictures of the patient's eyes, a handle with an integrated structure with the probe assembly, a portable device for carrying the probe assembly, and image processing. An analysis system for multiple symptom analysis and a terminal for outputting images, data, and reports.

In the present invention, the probe assembly 4 is an integrated structure consisting of an imaging assembly, an illumination light source 44, a camera module 45, a camera fixture 46, a control board 47 and a cover plate 48. As shown in FIG. 2, the imaging assembly, the illumination light source 44 and the camera module 45 are fixed on one side of the camera fixing device 46, and the control board 47 is fixed on the other side of the camera fixing device 46. At the same time, it is closed into a complete structure with a cover plate 48, and the imaging assembly includes sequentially The tapered tube 41, the fixed sleeve 42 and the optical filter 43 are provided. The fixed sleeve 42 is set into a light-gathering cavity structure, and openings are respectively opened before and after the light-gathering cavity, and the large opening of the light-gathering cavity is aligned with the The exit surface of the illuminating light source 44, the filter 43 is arranged on the light path between the illuminating light source 44 and the light collecting cavity, and the conical cylinder 41 is a Placido conical cylinder, so The tapered end of the conical tube 41 stretches into the light concentrating cavity from the small opening of the conical tube 41, so that the whole conical tube 41 is concentrically accommodated in the concentric cavity, and the conical tube 41 The flat bottom end leans against the small opening of the light-gathering cavity, and the imaging components of the device are compactly designed. The Placido cone design replaces the existing Placido ring design, which ensures the statistical accuracy of tear film breakup time and realizes the Placido ring structure. The whole probe assembly is miniaturized, and finally the size of the probe assembly 4 is reduced to about 10 cm in diameter and length, which occupies less space and has stronger applicability.

In this embodiment, the camera fixing device 46 is a cylindrical structure, and the front and rear sides of the camera fixing device 46 are respectively provided with interconnected cavities, and the optical filter 43, the illuminating light source 44 and the camera module 45 It is arranged in the front cavity in sequence from outside to inside, and the large opening of the light-gathering cavity of the fixed sleeve 42 is fixed on the outside of the front cavity to seal the front cavity, and the control board 47 is arranged on the rear side cavity, and closed with the cover plate 48, the input end of the control board 47 is connected to the PC through the serial interface, the output end of the control board is connected with the illumination light source 44 through the light source control module, and the imaging The component is provided with a front and rear through outlet, and the illumination light source and the camera assembly are respectively aligned with the outlet, and the outlet is aimed at the patient's eye, and the camera module images the patient's eye, and the generated The image is transmitted to the PC through the USB interface.

The illumination light source 44 is an LED ring light source, as shown in FIG. 3 , including a circuit substrate 440 and near-infrared LEDs 441 and white LEDs 442 uniformly arranged on the circuit substrate 440. The circuit substrate 440 adopts a ring structure and an aluminum substrate material. The wavelength of the near-infrared LED is 850nm, and the near-infrared LED and the white light LED are arranged at intervals to form a ring-shaped light source structure. Two circles of evenly arranged near-infrared LEDs and white light LEDs are concentrically arranged on the circuit substrate, so that they are uniformly irradiated on the patient's eyes. Improving the imaging quality, among them, the near-infrared LED can be driven independently and the brightness can be adjusted, and the white LED can also be driven independently and the brightness can be adjusted. The lighting source of the imaging system is designed as a multi-mode LED ring light source, which provides uniform, stable and reliable infrared and White light lighting environment, adjustable light source and brightness, realizes automatic switching of dry eye inspection mode.

The input end of the control board 47 is connected to the PC through a serial interface, and the output end of the control board 47 is connected to the lighting source 44 through a light source control module, which controls the lighting mode of the lighting light source 44. Specifically, When conducting statistical examination of tear film breakup time, the lighting mode was adjusted to white light irradiation, and the intensity of the irradiation light was adjusted; when the tear river height was measured, it was also adjusted to white light irradiation, and the light intensity was adjusted; when the meibomian gland image collection was enhanced, It is also adjusted to white light irradiation, and the light intensity is adjusted; when analyzing the lipid layer of the human eye, it is adjusted to near-infrared light irradiation, and the conical tube 41 is removed to adjust the light intensity. After the measurement mode is selected, the above-mentioned white light or near-infrared light is automatically switched, and the corresponding light intensity is automatically adjusted to meet different detection requirements.

The camera module 45 adopts a high-resolution color module, which is used for high-definition photographing and imaging of the patient's eyes, supports white light band imaging, and 850nm near-infrared band imaging, and supports autofocus, and the focus position is controllable. The camera module 45 is configured with a plurality of imaging modes corresponding to different measurement modes. The camera module 45 is connected to the PC control terminal through the USB interface, and the high-definition images of the eyes are transmitted to the PC. The imaging mode can be Switching is carried out through the PC control terminal, and the PC signal input terminal is provided with a tear film breakup time check button, a tear river height measurement button, a meibomian gland image acquisition and enhancement button, and a lipid layer analysis button, when one of the buttons is selected At this time, the lighting mode of the lighting source 44 is automatically switched to the corresponding lighting mode, and at the same time, the camera module 45 automatically adjusts the imaging mode and performs autofocus to perform high-definition imaging of the patient's eyes.

Portable device, the portable device includes a headrest assembly 1, an adjustable handle bar 2, an adjustable table assembly 3, a handle is provided at the lower end of the probe assembly 4, that is to say, the first end of the handle is connected to the lower end of the probe assembly 4, The handle is configured as a bendable structure, which can conveniently adjust the relative position of the probe assembly 4 and the handle. The second end of the handle is arranged on the adjustable workbench assembly 3 through a detachable part, and the head rest assembly 1 is arranged on the probe assembly 4. Behind the component 4, when the patient is positioned on the headrest component 1, adjust the front, rear, left, and right distances of the adjustable worktable component 3 and the probe component 4 relative to the headrest component 1 by swinging the adjustable hand lever 2, and at the same time Rotate the adjustable hand lever 2 up and down to adjust the upper and lower positions of the chin rest of the headrest assembly 1, thereby adjusting the position of the human eye, so that the illumination source and camera module in the probe assembly 4 are aligned with the patient's eyes to achieve the best imaging effect , realize rapid imaging detection, improve detection efficiency, and at the same time miniaturize the probe assembly, and make the entire dry eye analysis device portable. The probe assembly can be used independently as a handheld device, taking up less space, more convenient to use, and more applicable powerful.

as well as

An analysis device, which is integrated in a PC, is connected in communication with the probe assembly, and the analysis device includes an image data acquisition unit, a data detection unit, a data analysis unit and an information management output unit, and the data detection unit The unit includes a tear film breakup time inspection module, a tear river height measurement module, a meibomian gland image acquisition and enhancement module, and a lipid layer analysis module. The data detection unit is connected to the camera module through the image data acquisition unit, The image data acquisition unit outputs eye images in real time through a video terminal, the output end of the data detection unit is connected to the data analysis unit, and the data analysis unit outputs a detection report through an information management output unit.

The signal input end of the PC is connected to the serial port interface and the USB interface through the communication module for communication and data transmission, and is used for switching measurement modes and controlling corresponding lighting modes and imaging modes. The input end of the image data acquisition unit is connected with the output end of the camera module 45, and the eye image is transmitted to the PC. The measurement module, the meibomian gland image acquisition and enhancement module, the lipid layer analysis module and the video terminal are connected to transmit the eye images taken in each mode to the corresponding detection module. At the same time, the data analysis unit is connected with the tear film The rupture time inspection module, the lacrimal river height measurement module, the meibomian gland image acquisition and enhancement module, and the lipid layer analysis module are connected to the output terminals, and the data collected and generated by each module are analyzed accordingly to obtain the detection results. At the same time, the video terminal directly displays the captured images for intuitive display and observation analysis. The measurement results of this analysis system are accurate, objective and stable, and the inspection time is short, which can be quickly displayed on the video terminal.

The output end of the data analysis unit is connected with the information management output unit, and the system can diagnose and analyze the four aspects of dry eye syndrome, including tear film break-up time inspection, tear river height measurement, meibomian gland image shooting and enhancement, lipid Quality analysis, the data generated by these tests are processed by the information management output unit to produce reports and print out. At the same time, the image data and detection data are stored and archived in the PC.

Specifically, the signal input end of the PC is provided with a tear film breakup time check button, a tear river height measurement button, a meibomian gland image acquisition and enhancement button, and a lipid layer analysis button, and each button corresponds to a corresponding measurement mode, Each measurement mode corresponds to an illumination mode and an imaging mode. Under each measurement mode, the illumination mode of the illumination source 44 and the imaging mode of the camera module 45 are automatically adjusted. When one of the buttons is selected, the illumination mode of the illumination source 44 automatically Switch to the corresponding lighting mode, and at the same time, the camera module 45 automatically adjusts the imaging mode and performs auto-focus to perform high-definition imaging of the patient's eyes. The illumination light source 44 irradiates the patient's eye through the imaging component to provide illumination, and then the camera module 45 performs high-definition imaging on the patient's eye, and transmits the generated image to the PC through the USB interface for further processing. Data analysis and detection, storage and display analysis, the inspection process is non-invasive, reducing the pain of patients and the difficulty of inspection.

Embodiment two

In this embodiment, the handle is a hollow structure, the connecting wire of the probe assembly 4 passes through the handle and is connected to the analysis device, and the handle can be separated from the portable device to become an independent handheld analysis device; The headrest assembly is arranged behind the probe assembly, and the adjustable workbench assembly and the front, rear, left, and right distances of the probe assembly relative to the headrest assembly can be adjusted by swinging the adjustable hand lever front, rear, left, and right, and the headrest can be adjusted by rotating the adjustable hand lever up and down. The up and down position of the assembly's chin rest relative to the probe assembly. Specifically, the lower end of the handle is set on the adjustable table assembly 3 through a detachable part, and the headrest assembly 1 is arranged behind the probe assembly 4. When the patient is positioned on the headrest assembly 1, the hand can be adjusted by swinging. Adjust the front, rear, left, and right distances of the adjustable workbench assembly 3 and the probe assembly 4 relative to the headrest assembly 1 by moving the rod 2 forward, backward, left, and right, and at the same time adjust the upper and lower positions of the mandible rest of the headrest assembly 1 by rotating the adjustable hand lever 2 up and down. Thereby adjusting the position of the human eye so that the illumination light source and the camera module in the probe assembly 4 are aligned with the patient's eye to achieve the best imaging effect, realize fast imaging detection, improve detection efficiency, and have strong portability and higher adaptability .

For some special patients, the head cannot be placed on the detection device by themselves. In order to perform eye detection for these patients, the handle in this embodiment can be disassembled from the adjustable workbench assembly 3 and used as a handheld device for special patients. For inspection, you only need to point the handheld device at the patient's eyes, and the patient can complete the entire inspection process while lying down, which provides convenience for the patient and the operator. The handheld device can also be used on the base of the slit lamp, which can Deep space resources can be described as one design and three usage methods. For some inconveniences, it is not only convenient for doctors to operate, but also saves precious space resources in ophthalmology clinics to a certain extent.

Embodiment three

On the basis of Embodiment 1, as shown in Figure 2, a baffle 411 is arranged laterally on the flat bottom end of the conical cylinder 41, and a positioning groove 421 is opened on the small opening of the concentrating cavity, in order to meet the Different detection functions need to switch the imaging mode, so the conical cylinder 41 needs to be removed from the fixed sleeve. For this reason, in this embodiment, the conical cylinder 41 is detachably mounted on the fixed sleeve 42, the blocking piece 411 is clamped in the positioning groove 421, and the Placido cone design can be removed during use to meet the needs of different functional imaging.

Embodiment four

On the basis of Embodiment 1 or Embodiment 2, the inner wall of the light-gathering cavity is coated with a diffuse reflection coating, and the outgoing light of the illumination source is evenly reflected to the cone through the diffuse reflection coating. The conical surface of the tube gathers the outgoing light to the conical surface of the conical tube, which enhances the effectiveness of the irradiated light, reduces polarized light and light leakage, so that the outgoing light is concentrated on the patient's eyes, providing better lighting effect, and further Improve the imaging effect and improve the accuracy, objectivity and stability of the measurement results.

Embodiment five

On the basis of Embodiment 1, the centers of the circuit board 440, the optical filter 45, and the cone 41 are aligned with a through hole, and the shooting lens of the camera module 45 is aimed at the patient's eye through the through hole, for the camera The module 45 provides a shooting optical path, optimizes the imaging optical path, reduces the size of the probe assembly 4, and makes the analysis system miniaturized and portable.

As mentioned above, the portable dry eye detection instrument in the present invention includes a high-resolution image acquisition module, an intelligent light source control module, a multifunctional ring light source module, a software module, a data processing control system and a portable dry eye comprehensive analysis device. The high-resolution image acquisition module can acquire color images and near-infrared images. The autofocus function of the acquisition module meets the different imaging requirements of tear film breakup time measurement and meibomian gland imaging principles; the multi-functional ring light source module provides lighting environment and communicates through the serial port Connected with a PC, the upper computer realizes the intelligent light source control module through software, realizes a uniform infrared lighting environment and white light lighting environment, realizes statistical inspection of tear film breakup time, measurement of tear river height, enhancement of meibomian gland image collection and human eye lipid Layer analysis and other functions.

At the same time, the dry eye comprehensive analysis system of the present invention includes a color sensitive infrared camera module, an LED ring lighting source, a control panel, a portable dry eye comprehensive analysis device and a dry eye comprehensive analysis system module. The camera module, the ring light source, and the control board are integrated in the portable device. The control board realizes the intelligent light source control function, controls the ring light source lighting system, and provides a multi-mode lighting environment. The image data is obtained by the camera module and transmitted through the USB interface. To the PC, it is analyzed and calculated by the PC dry eye syndrome comprehensive analysis system module and the results are displayed on the PC video terminal, and the diagnostic report can be printed out through the terminal.

Portable devices include head rest assembly, adjustable table assembly, adjustable hand bar, probe assembly, display screen, laptop computer, etc. Adjust the front and rear, left and right positions of the adjustable workbench, and the up and down position of the chin rest through the adjustable hand lever, so as to achieve fast and accurate pupil alignment; the instrument host is connected to the laptop through the USB3.0 interface at the bottom to realize mutual Realization of communication and related functions. The probe assembly is mainly composed of Placido cone tube, fixed sleeve, ring light source, CCD camera, camera fixing device, etc. The structural design is convenient for disassembly and installation.

The imaging system includes a camera module, LED ring light source, probe assembly, control board and USB device interface, where the camera module, LED ring light source and control board are integrated inside the imaging system equipment, the camera module is connected to the PC, and the control board is connected to The ring light source is controlled by the host computer serial port communication, and the PC is responsible for signal control and data input and output. The dry eye syndrome comprehensive analysis software system module is arranged on the PC side to display, store and process the images collected by the camera module, and to display, store and print out the measurement results. The brightness adjustment of the ring light source inside the imaging system of the device and the switch control of the light source are input by the signal sent by the PC section, and the software system is used to process image data collection, image data analysis and judgment, and output of diagnosis results.

The light source circuit adopts a ring structure and aluminum substrate material, and the wavelength of the near-infrared LED is 850nm to meet the imaging requirements. The ring light source is designed in two circles, and the infrared LEDs and white LEDs are evenly arranged on the two circles of the aluminum substrate to ensure uniform lighting brightness. The infrared light source is designed to be adjustable in brightness, and the white light source is designed to be adjustable in brightness.

The portable device includes a head rest assembly 1 , an adjustable handle bar 2 , an adjustable workbench assembly 3 and a probe assembly 4 . The front and rear, left and right positions of the adjustable workbench, and the up and down position of the chin rest can be adjusted through the adjustable hand lever, so as to adjust the position of the human eye to achieve the best imaging effect.

Probe assembly 4 is made up of Placido conical tube 41, fixed sleeve 42, optical filter 43, ring light source 44, camera module 45, camera fixing device 46, control circuit board 47 and cover plate 48, the front face of Placido conical tube Designed with two small baffles for easy disassembly and installation. The support structure at the bottom of the probe assembly is compatible with the slit lamp, and can be placed on the base of the slit lamp when in use, or can be removed and used by hand.

The camera module selects a high-resolution color module, supports 850nm near-infrared band imaging, supports auto-focus, and the focus position is controllable. The imaging mode is controlled by PC software.

The dry eye syndrome comprehensive analysis software system is arranged on a PC, and is connected to the structural device through a serial cable and USB to realize communication and data interaction. The dry eye comprehensive analysis software system includes a communication module, an image data acquisition unit, a tear film breakup time inspection module, a tear river height measurement module, a meibomian gland image acquisition and enhancement module, a data analysis module and an information management output module. Syndrome analysis function.

The Placido cone is designed for tear film breakup time inspection. During the inspection, the examinee puts his head on the lower jaw of the head rest 1, and the operating physician adjusts the human eye (left eye or right eye) for imaging through the adjustable handle 2 In the center, the testee looks straight ahead with both eyes, blinks normally until the center point is aligned with the pupil, and then asks the testee to keep their eyes open until the system automatically records the time and location of the first tear film rupture. You need to close your eyes and rest for at least 1 minute for re-measurement. The data analysis module supports multiple measurements and multiple records, which is convenient for doctors to analyze the condition statistically. After the tear film break-up time inspection, the tear river height can be measured. tube, the subject puts his head on the lower jaw of the headrest 1, and the operator captures the image of the tear river of the patient, and uses the measurement tool of the software system to measure the height of the tear river directly below the center of the pupil; the image of the meibomian gland The acquisition includes infrared imaging of the meibomian glands of the upper eyelid and lower eyelid, and the software system enhances the analysis and processing to assist doctors in clinical dry eye diagnosis; lipid layer analysis imaging, instructing the subject to blink, capture the lipid layer image of the human eye. The four modes of imaging systems are automatically switched through the software system on the PC side to complete the analysis of dry eye disease, and then adopt an individualized treatment plan for the cause, providing clinicians with a direct, fast, written, non-invasive, objective and comprehensive The diagnostic basis to assist in the diagnosis of dry eye syndrome.

The measurement results of the system and device are accurate, objective and stable, the inspection time is short, and can be quickly displayed on the video terminal; and the entire inspection process is non-invasive, reducing the pain of patients and the difficulty of inspection; the portable dry eye analysis device is highly portable, The lighting and imaging components are ingeniously designed, and the bottom structure is compatible with the slit lamp structure. When in use, it can be removed as a hand-held device for special patient examination, and can also be used on the base of the slit lamp. It can be described as one design with three usage methods, which is not only convenient for doctors to operate, It also saves precious space resources in the ophthalmology clinic to a certain extent; the lighting source of the imaging system of the present invention is designed as a multi-mode LED ring light source, which provides a uniform, stable, and reliable infrared and white light lighting environment, and the light source and brightness are adjustable. Automatic switching of eye examination modes; the design of the imaging components of the device is small and exquisite, and the Placido cone design replaces the existing Placido ring design, which ensures the statistical accuracy of the tear film breakup time and realizes the simplification of the Placido ring structure; the Placido cone The cartridge design can be removed during use to meet the needs of different functional imaging; dry eye syndrome comprehensive analysis software system completes the diagnostic analysis of four aspects of dry eye syndrome, including tear film breakup time inspection, tear river height measurement, meibomian gland image Shooting and enhancement, lipid layer analysis.

Although the embodiment of the present invention has been disclosed as above, it is not limited to the use listed in the specification and implementation, it can be applied to various fields suitable for the present invention, and it can be easily understood by those skilled in the art Therefore, the invention is not limited to the specific details and examples shown and described herein without departing from the general concept defined by the claims and their equivalents.

Claims (5)

1. A portable dry eye syndrome detector, characterized in that, comprising: The probe assembly includes an imaging assembly, an illumination light source, a camera module, a camera fixing device, a control panel and a cover plate arranged in sequence, the imaging assembly is provided with an exit port, and the illumination light source and the camera module are respectively aligned exit port; a handle, the first end of which is connected to the lower end of the probe assembly, and the handle is configured as a bendable structure; Portable device, which includes a base, a headrest assembly, an adjustable handle bar and an adjustable workbench assembly, the bottom of the headrest assembly is fixed on the base, and the adjustable workbench assembly is movably installed on the On the base, the second end of the handle is detachably mounted on the adjustable workbench assembly; and An analysis device, which is integrated in a PC, is connected in communication with the probe assembly, and the analysis device includes an image data acquisition unit, a data detection unit and a data analysis unit; The imaging assembly includes a filter, a fixing sleeve and a tapered tube, the fixing sleeve is arranged as a light-gathering cavity structure, the large opening of the light-gathering cavity structure is aligned with the exit surface of the illumination source, and the The optical filter is arranged on the optical path between the illumination source and the light-gathering cavity structure, the tapered cylinder is a Placido cone-shaped cylinder, and the tapered end of the cone-shaped cylinder is separated from the light-gathering cavity structure. The small opening protrudes into the light concentrating cavity structure, and the flat bottom end of the tapered tube leans against the small opening of the light concentrating cavity structure; The inner sidewall of the light-gathering cavity structure is coated with a diffuse reflection coating, and the outgoing light of the illumination source is evenly reflected on the tapered surface of the tapered cylinder through the diffuse reflection coating; The lighting source is an LED ring light source, including a circuit substrate and near-infrared LEDs and white LEDs evenly arranged on the circuit substrate. The circuit substrate adopts a ring structure and aluminum substrate material. The wavelength of the near-infrared LED is 850nm. The white light LEDs are arranged at intervals to form a ring-shaped light source structure, and several circles of evenly arranged near-infrared LEDs and white light LEDs are concentrically arranged on the circuit substrate, and the near-infrared LEDs and white light LEDs are independently driven and have adjustable brightness; The center of the circuit substrate, the optical filter, and the tapered tube are aligned with a through hole to form the exit port that emits outward, and the exit port is aligned with the patient's eye; The camera fixing device is a cylindrical structure, and the front and rear sides of the camera fixing device are respectively provided with interconnected cavities, and the optical filter, lighting source and camera module are sequentially arranged in the front cavity from outside to inside Inside, the large opening of the light-gathering cavity structure of the fixing sleeve is fixed on the outside of the front cavity, the control board is arranged in the rear cavity and closed with the cover plate, and the input end of the control board passes through the serial port The interface communicates with the PC, the output end of the control board is connected to the illumination light source through the light source control module, the camera module images the patient's eyes, and transmits the generated image to the PC through the USB interface. 2. The portable dry eye syndrome detector according to claim 1, wherein the camera module is a high-resolution color module, supports white light band imaging, 850nm near-infrared band imaging, supports autofocus, and focuses The position is controllable, and the camera module is equipped with multiple imaging modes corresponding to different measurement modes, and the imaging mode of the camera module can be switched through a PC. 3. The portable dry eye syndrome detector according to claim 2, wherein the handle is a hollow structure, the connecting wire of the probe assembly passes through the handle and is connected to the analysis device, and the handle can be Separate from the portable device so that the probe assembly can be used independently as a handheld device; the head rest assembly is arranged behind the probe assembly, and the adjustable workbench assembly and the probe assembly can be adjusted by swinging the adjustment hand lever front, rear, left, and right With respect to the front, back, left, and right distances of the head rest assembly, the up and down position of the mandible rest of the head rest assembly relative to the probe assembly is adjusted by rotating the adjusting handle up and down. 4. The portable dry eye syndrome detector according to claim 3, wherein the data detection unit includes a tear film breakup time inspection module, a tear river height measurement module, a meibomian gland image acquisition and enhancement module, a lipid Layer analysis module, the data detection unit is connected with the camera module through the image data acquisition unit, the image data acquisition unit outputs eye images in real time through the video terminal, the output end of the data detection unit is connected to the The data analysis unit is connected, and the data analysis unit outputs the detection report through the information management output unit. 5. portable dry eye syndrome detector as claimed in claim 4, is characterized in that, the signal input end of described PC is provided with tear film breakup time check button, tear river height measurement button, meibomian gland image acquisition and enhancement. button, lipid layer analysis button, each button corresponds to a corresponding measurement mode, and each measurement mode corresponds to an illumination mode and an imaging mode.