CN106691960A - Acne-removing composition, acne-removing skin cream and preparation method of acne-removing skin cream - Google Patents
Acne-removing composition, acne-removing skin cream and preparation method of acne-removing skin cream Download PDFInfo
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- CN106691960A CN106691960A CN201611143237.0A CN201611143237A CN106691960A CN 106691960 A CN106691960 A CN 106691960A CN 201611143237 A CN201611143237 A CN 201611143237A CN 106691960 A CN106691960 A CN 106691960A
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- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 206010000496 acne Diseases 0.000 title claims abstract description 34
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000002884 skin cream Substances 0.000 title abstract 6
- ACEWLPOYLGNNHV-UHFFFAOYSA-N Ibuprofen piconol Chemical compound C1=CC(CC(C)C)=CC=C1C(C)C(=O)OCC1=CC=CC=N1 ACEWLPOYLGNNHV-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229950005954 ibuprofen piconol Drugs 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 230000003255 anti-acne Effects 0.000 claims description 56
- 239000006071 cream Substances 0.000 claims description 46
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 14
- 229930013930 alkaloid Natural products 0.000 claims description 10
- 150000003797 alkaloid derivatives Chemical class 0.000 claims description 10
- 239000003921 oil Substances 0.000 claims description 9
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- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 8
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- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 8
- 229940041616 menthol Drugs 0.000 claims description 8
- 239000002480 mineral oil Substances 0.000 claims description 8
- 235000010446 mineral oil Nutrition 0.000 claims description 8
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 8
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 8
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- 238000001816 cooling Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000008213 purified water Substances 0.000 claims description 6
- AXPZIVKEZRHGAS-UHFFFAOYSA-N 3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one Chemical compound [O-][N+](=O)C1=CC=CC=C1OCC1OC(=O)C(CC=2C=CC=CC=2)C1 AXPZIVKEZRHGAS-UHFFFAOYSA-N 0.000 claims description 5
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- 239000002537 cosmetic Substances 0.000 claims description 5
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- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims description 4
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- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical class CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 238000007599 discharging Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims 4
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims 4
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 2
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 claims 1
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- 230000000694 effects Effects 0.000 abstract description 16
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- 231100000344 non-irritating Toxicity 0.000 abstract 1
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 abstract 1
- 208000008742 seborrheic dermatitis Diseases 0.000 abstract 1
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- 230000000052 comparative effect Effects 0.000 description 12
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- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 7
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 7
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
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- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
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- HRBMESHSNKKVBJ-OLKYXYMISA-N [(1r,4r,5r,7s)-8-benzyl-7-[[4-(dimethylamino)phenyl]carbamoyl]-8-azabicyclo[3.2.1]octan-4-yl] n-ethylcarbamate Chemical compound N1([C@@H]2C[C@@H]([C@H]1CC[C@H]2OC(=O)NCC)C(=O)NC=1C=CC(=CC=1)N(C)C)CC1=CC=CC=C1 HRBMESHSNKKVBJ-OLKYXYMISA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to an acne-removing composition, acne-removing skin cream and a preparation method of the acne-removing skin cream. The active ingredients of the acne-removing composition are prepared from the following components in parts by mass: 1-10 parts of ibuprofen piconol, 0.5-5 parts of avenanthramides and 0.5-5 parts of chlorhexidine digluconate. The acne-removing composition disclosed by the invention has an obvious acne-removing effect, has obvious effects of treating whelk, pimples and seborrheic dermatitis, is fast in efficacy, mild and non-irritating to skin, does not have any toxic or side effect and does not produce drug dependence. The acne-removing composition disclosed by the invention is prepared into the acne-removing skin cream, and the acne-removing skin cream has an acne removing function and achieves the effects of replenishing water for skin, moisturizing, moistening the skin, beautifying the skin and the like.
Description
Technical field
The present invention relates to skin care item or cosmetic field, more particularly to a kind of composition of anti-acne, anti-acne face cream and
Its preparation method.
Background technology
Acne (small pox) is a kind of common skin disease, and modern medicine is thought, small pox is the chronic inflammation of hair follicle, sebaceous glands
Venereal disease becomes, and is more common in face, chest and back isocortex and secretes vigorous position, clinical manifestation be apt to occur in the acne of face, papule,
The polymorphy skin damaged such as warts, tubercle, because acne is apt to occur in puberty, also commonly known as " whelk ".In the modern life, by
In the influence of rhythm of life and eating habit, the acne scar formed after acne and acne healing annoyings many people seeking beauties, patient
Easily there are social mentality's problems such as impaired self-esteem, self-confidence, embarrassment, depression, anxiety, human communication disorders and influence can be caused just
The problems such as industry, marriage and childbirth.
At present, in the market is various for treating the product category of whelk, and effect is also uneven, mainly there is anti-acne external application
Two kinds of medicine (or made an addition to skin care item or cosmetics in) and anti-acne medicine for oral administration, there is two kinds of Chinese herbal medicine and Western medicine.Anti-acne
Containing antibiotic Western medicine, side effect is larger, the stimulation to skin is also big, easily produces dependence, and long-term taking can aggravate liver kidney more
Burden.In anti-acne Chinese herbal medicine, there is slowly effect, easily in externally applied drug, effect is bad, and medicine for oral administration has medicine time
The problems such as length, slowly effect, and quite a few people is because the big problem of anti-acne Chinese herbal medicine smell for oral administration is difficult to adhere to taking, effect
Fruit is difficult to embody.Anti-acne method also has Chemical peeling, physical treatment etc. to perform the operation, but its somewhat expensive.
The content of the invention
Based on this, the invention provides a kind of composition of anti-acne.
Concrete technical scheme is as follows：
A kind of composition of anti-acne, its active component is prepared from by the component of following mass parts：
Ibuprofen Piconol 1-10 parts
0.5-5 parts of oat alkaloid
0.5-5 parts of gluconic acid chlorhexidine.
Wherein in some embodiments, the composition of the anti-acne, its active component is prepared by the component of following mass parts
Form：
Ibuprofen Piconol 2-6 parts
1-3 parts of oat alkaloid
1-3 parts of gluconic acid chlorhexidine.
Wherein in some embodiments, the composition of the anti-acne, its active component is prepared by the component of following mass parts
Form：
Ibuprofen Piconol 3.5-4.5 parts
1.5-2.5 parts of oat alkaloid
1.5-2.5 parts of gluconic acid chlorhexidine.
Present invention also offers the application of the composition of above-mentioned anti-acne.
Concrete technical scheme is as follows：
Application of the combinations of the above thing in anti-acne skin care item or acne-eliminating cosmetic is prepared.
Present invention also offers a kind of anti-acne face cream.
Concrete technical scheme is as follows：
A kind of anti-acne face cream, is prepared from by acceptable auxiliary material in combinations of the above thing and face cream.
Wherein in some embodiments, percentage by weight of the composition in face cream is 2-20%.
Wherein in some embodiments, percentage by weight of the composition in face cream is 7-9%.
Wherein in some embodiments, described anti-acne face cream is prepared from by the raw material of following percentage by weight：
Composition 7-9%, azone 0.8-1.2% described in claim any one of 1-3, ethanol 4.5-5.5%, menthol 0.8-
1.2%th, vaseline 4.5-5.5%, mineral oil 7-8%, PEG400 4.5-5.5%, cetostearyl alcohol 5.5-6.5%,
Methyl p-hydroxybenzoate 0.12-0.17%, propylben 0.08-0.12%, 1,3-BDO 2.5-3.5%, poly- propionyl
Amine and polyethyleneglycol diacrylate 1.5-2.5%, essence 0.45-0.55%, purifying water surplus.
Present invention also offers the preparation method of above-mentioned anti-acne face cream.
Concrete technical scheme is as follows：
A kind of preparation method of above-mentioned anti-acne face cream, comprises the following steps：
Purified water, PEG400 and 1 are added in kettle, 3 butanediols, heating for dissolving obtains aqueous mixture；
Vaseline, mineral oil, cetostearyl alcohol, azone, menthol, propylben and para hydroxybenzene are added in oil cauldron
Methyl formate, heating for dissolving obtains oil mixture；
Aqueous mixture and oil mixture are pumped into vacuum emulsifying machine, homogeneous stirs, added after cooling essence,
Ethanol, oat alkaloid, Ibuprofen Piconol and gluconic acid chlorhexidine, homogeneous are stirred, and cooling, discharging is obtained final product.
Wherein in some embodiments, the temperature of the heating for dissolving is 70-80 DEG C, and the cooling is to be cooled to 35-45
℃。
The composition of anti-acne of the invention, anti-acne face cream have advantages below and beneficial effect：
The present inventor by long-term experience accumulation and it is substantial amounts of experimental studies have found that：By Ibuprofen Piconol, swallow
Wheat alkaloid and gluconic acid chlorhexidine are coordinated with certain proportion has significant anti-acne effect.The composition of anti-acne of the invention
There is anti-(suppression) bacterium to act on to (the moon) (sun) property staphylococcus, Escherichia coli, Candida albicans, to acne vulgaris bacillus, fungi,
Dermatitis, neurodermatitis, contact dermatitis and various skin blebs, allergy etc. are effectively.Especially to whelk, dark sore, seborrheica
The therapeutic effect of dermatitis is notable.Be combined for Chinese medicine and Western medicine by the composition of anti-acne of the invention, works faster and curative effect is aobvious
Write, at the same it is gentle to skin it is non-stimulated, have no toxic side effect, drug dependence will not be produced, will not be recurred after recovery from illness.
By the moisturizing in the composition of anti-acne of the invention and skin care item or cosmetics, emollient ingredient and other auxiliary material phases
With reference to anti-acne face cream is prepared into, the effect such as moisturizing, moisturizing, moisturizing, good skin is played to skin while with acne-removal function,
The comprehensive of function above is that the medicines such as antibiotic, hormone cannot replace.
Specific embodiment
Composition, anti-acne face cream of anti-acne of the invention and preparation method thereof are carried out more below by way of specific embodiment
Detailed description.
Embodiment 1
The present embodiment provides a kind of anti-acne face cream, is prepared from the following materials：
The preparation method of the anti-acne face cream of the present embodiment is as follows：
Purified water, PEG400 and 1,3 butanediols is added to be heated to 75 DEG C of dissolvings, obtain water and mix in kettle
Thing；
Vaseline, mineral oil, cetostearyl alcohol, azone, menthol, propylben and para hydroxybenzene are added in oil cauldron
Methyl formate, is heated to 75 DEG C of dissolvings, obtains oil mixture；
Aqueous mixture and oil mixture are pumped into vacuum emulsifying machine, homogeneous stirs, added after being cooled to 40 DEG C
Enter essence, ethanol, oat alkaloid, Ibuprofen Piconol and gluconic acid chlorhexidine, homogeneous stirs, and is cooled to 38 DEG C, goes out
Material, quality inspection, packing is filling, and packaging is obtained final product.
Embodiment 2
The present embodiment provides a kind of anti-acne face cream, is prepared from the following materials：
The preparation method of the anti-acne face cream of the present embodiment is with embodiment 1.
Embodiment 3
The present embodiment provides a kind of anti-acne face cream, is prepared from the following materials：
| Material name | Mass percent |
| Ibuprofen Piconol | 6% |
| Oat alkaloid | 1% |
| Gluconic acid chlorhexidine | 3% |
| Azone | 1% |
| Ethanol | 5% |
| Menthol | 1% |
| Vaseline | 5% |
| Purified water | Surplus |
| Mineral oil | 8% |
| PEG400 | 5% |
| Cetostearyl alcohol | 6% |
| Methyl p-hydroxybenzoate | 0.15% |
| Propylben | 0.1% |
| 1,3-BDO | 3% |
| Poly- propionamide and polyethyleneglycol diacrylate | 2% |
| Essence | 0.5% |
The preparation method of the anti-acne face cream of the present embodiment is with embodiment 1.
Comparative example 1
This comparative example provides a kind of face cream, is prepared from the following materials：
| Material name | Mass percent |
| Ibuprofen Piconol | 2% |
| Azone | 1% |
| Ethanol | 5% |
| Menthol | 1% |
| Vaseline | 5% |
| Purified water | Surplus |
| Mineral oil | 8% |
| PEG400 | 5% |
| Cetostearyl alcohol | 6% |
| Methyl p-hydroxybenzoate | 0.15% |
| Propylben | 0.1% |
| 1,3-BDO | 3% |
| Poly- propionamide and polyethyleneglycol diacrylate | 2% |
| Essence | 0.5% |
The preparation method of the anti-acne face cream of the present embodiment is with embodiment 1.
Comparative example 2
This comparative example provides a kind of face cream, is prepared from the following materials：
The preparation method of the anti-acne face cream of the present embodiment is with embodiment 1.
Comparative example 3
This comparative example provides a kind of face cream, is prepared from the following materials：
| Material name | Mass percent |
| Oat alkaloid | 2% |
| Azone | 1% |
| Ethanol | 5% |
| Menthol | 1% |
| Vaseline | 5% |
| Purified water | Surplus |
| Mineral oil | 8% |
| PEG400 | 5% |
| Cetostearyl alcohol | 6% |
| Methyl p-hydroxybenzoate | 0.15% |
| Propylben | 0.1% |
| 1,3-BDO | 3% |
| Poly- propionamide and polyethyleneglycol diacrylate | 2% |
| Essence | 0.5% |
The preparation method of the anti-acne face cream of the present embodiment is with embodiment 1.
Comparative example 4
This comparative example provides a kind of face cream, is prepared from the following materials：
The preparation method of the anti-acne face cream of the present embodiment is with embodiment 1.
Embodiment 4
The face cream of embodiment 1-3 and comparative example 1-4 is carried out into clinical effect trial.
First, subject
Randomly select the whelk patient (face has obvious acne and small pox) 420 of 15-30 Sui, its average age
It is 20 years old, men and women half and half, is equally divided into 7 groups, every group of men and women half and half.Subject's energy compatibility test well, in the trial employment period
Good daily life system time and eating habit can be kept.
2nd, given the test agent, application method
The face cream that given the test agent is prepared for the anti-acne face cream and comparative example 1-4 of embodiment 1-3；
Application method：After morning and evening face cleaning, given the test agent is taken in right amount, be applied to affected part.This experiment 7 days is 1 course for the treatment of, altogether examination
With 2 courses for the treatment of.Paid a return visit after using 2 years and 4 years respectively.
3rd, evaluation of clinical curative effect standard
Recovery from illness：Small pox, acne print disappear, and skin damaged disappears, skin smooth finish, without recurrence after half a year of being discontinued；
Effectively：Total skin damaged number reduces more than 60%, remains a small amount of acne, papule；
It is invalid：Reduced without significant change or total skin damaged number and be less than 40%.
4th, result on trial analysis
Result is as shown in table 1.During subject's face cream on probation, do not occur pruitus, shouting pain, redness etc.
Adverse reaction.Anti-acne face cream of the invention preferable synergistic function because acne-removing composition has, cure rate is higher, far
Higher than the face cream of comparative example 1-4.Wherein preferably, after trying out 1 course for the treatment of, total effective rate reaches 79%, examination to the effect of embodiment 1
After with 2 courses for the treatment of, total effective rate reaches 100%.Recovery from illness patient to embodiment 1-3 is returned respectively after 2 years and after 4 years
Visit, no case was recurrence.Recovery from illness patient to comparative example 1-3 pays a return visit respectively after 2 years and after 4 years, and recurrence rate is respectively
20% and 35%.
The anti-acne face cream clinical effect trial result of table 1
It is below the specific case in part：
1st, willow ××, female, 25 years old, whelk patient, facial large area acne long was protected using the anti-acne of the embodiment of the present invention 1
Skin frost, after morning and evening face cleaning, takes anti-acne face cream and is applied to affected part in right amount, is within 7 days 1 course for the treatment of, and after trying out 1 course for the treatment of, small pox is complete
Totally disappeared and remove, be continuing with one month, flexible using rear skin smooth, acne print disappears, and has rosy cheeks, and feedback skin is without any
, there are not the adverse reactions such as pruitus, shouting pain, redness in excitant.Paid a return visit after 2 years, without recurrence.
2nd, river ××, man, 29 years old, whelk patient, forehead and chin portion acne long use dispelling for the embodiment of the present invention 1
Acne face cream, after morning and evening face cleaning, takes anti-acne face cream and is applied to affected part in right amount, is within 7 days 1 course for the treatment of, after trying out 1 course for the treatment of, acne
Acne is substantially eliminated, and is continuing with one month, and small pox is completely eliminated, and feedback skin without any excitant, do not occur pruitus,
The adverse reactions such as shouting pain, redness.Paid a return visit after 2 years, without recurrence.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
Apply all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, the scope of this specification record is all considered to be.
Embodiment described above only expresses several embodiments of the invention, and its description is more specific and detailed, but simultaneously
Can not therefore be construed as limiting the scope of the patent.It should be pointed out that coming for one of ordinary skill in the art
Say, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of composition of anti-acne, it is characterised in that its active component is prepared from by the component of following mass parts：
Ibuprofen Piconol 1-10 parts
0.5-5 parts of oat alkaloid
Chlorhexidine gluconate 0.5-5 parts.
2. the composition of anti-acne according to claim 1, it is characterised in that its active component by following mass parts component
It is prepared from：
Ibuprofen Piconol 2-6 parts
1-3 parts of oat alkaloid
Chlorhexidine gluconate 1-3 parts.
3. the composition of anti-acne according to claim 2, it is characterised in that its active component by following mass parts component
It is prepared from：
Ibuprofen Piconol 3.5-4.5 parts
1.5-2.5 parts of oat alkaloid
Chlorhexidine gluconate 1.5-2.5 parts.
4. application of the composition described in any one of claim 1-3 in anti-acne skin care item or acne-eliminating cosmetic is prepared.
5. a kind of anti-acne face cream, it is characterised in that can in the composition and face cream as described in claim any one of 1-3
The auxiliary material of receiving is prepared from.
6. anti-acne face cream according to claim 5, it is characterised in that weight percent of the composition in face cream
Than being 2-20%.
7. anti-acne face cream according to claim 6, it is characterised in that weight percent of the composition in face cream
Than being 7-9%.
8. anti-acne face cream according to claim 7, it is characterised in that prepared by the raw material of following percentage by weight and
Into：Composition 7-9%, azone 0.8-1.2% described in claim any one of 1-3, ethanol 4.5-5.5%, menthol 0.8-
1.2%th, vaseline 4.5-5.5%, mineral oil 7-8%, PEG400 4.5-5.5%, cetostearyl alcohol 5.5-6.5%, right
Methyl hydroxybenzoate 0.12-0.17%, propylben 0.08-0.12%, 1,3-BDO 2.5-3.5%, poly- propionamide
With polyethyleneglycol diacrylate 1.5-2.5%, essence 0.45-0.55%, purifying water surplus.
9. the preparation method of the anti-acne face cream described in a kind of claim 8, it is characterised in that comprise the following steps：
Purified water, PEG400 and 1 are added in kettle, 3 butanediols, heating for dissolving obtains aqueous mixture；
Vaseline, mineral oil, cetostearyl alcohol, azone, menthol, propylben and P-hydroxybenzoic acid are added in oil cauldron
Methyl esters, heating for dissolving obtains oil mixture；
Aqueous mixture and oil mixture are pumped into vacuum emulsifying machine, homogeneous stirs, essence, second are added after cooling
Alcohol, oat alkaloid, Ibuprofen Piconol and chlorhexidine gluconate, homogeneous are stirred, and cooling, discharging is obtained final product.
10. the preparation method of anti-acne face cream according to claim 9, it is characterised in that the temperature of the heating for dissolving
It it is 70-80 DEG C, the cooling is to be cooled to 35-45 DEG C.
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|---|---|---|---|
| CN201611143237.0A CN106691960A (en) | 2016-12-12 | 2016-12-12 | Acne-removing composition, acne-removing skin cream and preparation method of acne-removing skin cream |
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| CN201611143237.0A CN106691960A (en) | 2016-12-12 | 2016-12-12 | Acne-removing composition, acne-removing skin cream and preparation method of acne-removing skin cream |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107213038A (en) * | 2017-06-12 | 2017-09-29 | 南京凯创协同纳米技术有限公司 | Anti-acne face cream and preparation method thereof |
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| CN1552303A (en) * | 2003-06-03 | 2004-12-08 | 张金铎 | Beauty lotion cream and its preparation |
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| CN1552303A (en) * | 2003-06-03 | 2004-12-08 | 张金铎 | Beauty lotion cream and its preparation |
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