CN106668841A - Anti-tumor yak ossein protein peptide composition and preparation method thereof - Google Patents
Anti-tumor yak ossein protein peptide composition and preparation method thereof Download PDFInfo
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- CN106668841A CN106668841A CN201510742382.XA CN201510742382A CN106668841A CN 106668841 A CN106668841 A CN 106668841A CN 201510742382 A CN201510742382 A CN 201510742382A CN 106668841 A CN106668841 A CN 106668841A
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Abstract
The invention discloses an anti-tumor yak ossein protein peptide composition. The anti-tumor yak ossein protein peptide composition comprises 15 to 25 parts of yak ossein protein peptide powder, 2 to 4 parts of chicory powder, 40 to 50 parts of mixed berry primary pulp, 10 to 20 parts of cordyceps militaris, 10 to 20 parts of lucid ganoderma, 10 to 20 parts of mushroom, 5 to 15 parts of grifola frondosa, and 5 to 15 parts of cordyceps. The invention also provides a preparation method of the anti-tumor yak ossein protein peptide composition. The anti-tumor yak ossein protein peptide composition provided by the invention is good in treatment effect, low in toxic and side effects, low in cost, simple and convenient in process, high in efficiency, and environment friendly, and maintains the biological activity of a separated substance to the greatest extent.
Description
Technical field
The invention belongs to derive from the medicinal preparation of mammal, more particularly to one kind is made using Os Bovis grunniens collagen peptide
Anti-tumor compositions health food.
Background technology
Qinghai has abundant Os Bovis grunniens resource, and exploitation in recent years has the basic biochemistries such as bone meal, gelatin, peptone, yak chrondroitin former
The health food such as material and Medulla Bovis grunniens powder.Jing Atomic Absorption Spectrometries, contain K, Na, Ca, Mg, P, Cu, Zn in Os Bovis grunniens,
12 kinds of mineral elements such as Fe, Mn, Ni, Pb, Cd, have particularly important effect to the growth promoter of skeleton.
Jing is studied, and Os Bovis grunniens are carried out with collagen protein extractive process carries out ossein extraction and complex enzyme hydrolysis, obtains small molecule ammonia
The collagen peptide of base acid succeeds, and obtains patent.A kind of Os Bovis grunniens collagen peptide of the patent No. 201310271584.1
Preparation method, Authorization Notice No. CN103783254B, authorized announcement date 2015 year 09 month 09 day.
Cancer is a kind of malignant tumor, and the nutrient substance that cancerous cell can make one internal is consumed in a large number；Cancerous cell discharges various poison
Element, cancerous cell also can be transferred to whole body growth and breeding everywhere, cause human body to be become thin, powerless, anemia, inappetence, heating
And serious organ function is damaged.Malignant tumor can also destroy the 26S Proteasome Structure and Function of tissue, organ, cause exhaustion and
It is dead.At present the essential therapeutic arsenals of tumor are operation, chemotherapy, radiotherapy.Also there is the successful experience for the treatment of by Chinese herbs cancer.But
It is still no that anti-tumor drug is prepared as raw material with the collagen peptide of small molecule aminoacid.
The content of the invention
It is an object of the present invention to Os Bovis grunniens collagen peptide as major ingredient, make a kind of antitumor drug, there is provided a kind of anticancer
Novel drugs.It is beneficial to absorption of human body, is easy to use.
The technical scheme is that a kind of antitumor Os Bovis grunniens collagen peptide compositionss are made up of following material, its is heavy
Measuring component is：
Wherein with Os Bovis grunniens collagen peptide as major ingredient, Os Bovis grunniens collagen peptide be Os Bovis grunniens through steaming and decocting, complex enzyme hydrolysis,
Decolouring, membrane filtration, evaporation and concentration and spray drying are obtained.Os Bovis grunniens small-molecular peptides may not necessarily digest through gastrointestinal, liver
Etc. extremely strong absorbability, gastrointestinal, burden of liver are mitigated significantly, greatly improve bioavailability；Os Bovis grunniens small-molecular peptides can be with
The synthesis for directly participating in human body collagen protein plays a role again without breaks down into amino acids, and polypeptide does not then reach these.
Compound certain kind of berries oleo stock be rich in anthocyanidin, vitamin and mineral, the combination of anthocyanidin and collagen protein and hard elastics albumen,
So that forming one layer of antioxidative protective layer on the cell membrane of mastocyte and basophil, play and repair and protect cell
Effect.Compound certain kind of berries oleo stock can be cranberry oleo stock, blueberry protoplasm, blackberry plasmogen and Fructus Fragariae Ananssae oleo stock.
Cordycepin, ergosterol, Cordyceps polysaccharide, superoxide dismutase and selenium are rich in Cordyceps militaris (L.) Link.；Cordyceps militaris (L.) Link. element can antiviral,
Antibacterial, the tumour growth that substantially suppresses, the RNA and DNA synthesis of interference human body；Ergosterol, superoxide dismutase are to suppressing
Or elimination urges the superoxide radical formation of people's aging and anticancer, health care, attenuation to have good action.
Rich in Ganoderma triterpenoidss and polysaccharide in Ganoderma.Triterpeness Ganodenic acid has the cytotoxicity of the specificity for tumor cell,
Tumor cell is directly killed, diffusion is prevented, until tumors destroyed cell.Ganoderan can suppress oncoprotein Acacia farnesiana Willd. ester to turn
The activity of enzyme (FPT) is moved, the Acacia farnesiana Willd. esterification modification of Tumour DNA is blocked, the conversion and film fusion of tumor cell is prevented,
So as to suppress Nasopharyngeal neoplasms.
Contain lentinan in Lentinus Edodess, lentinan scalable people Xiu Nei has the T cell activity of immunologic function, it is possible to decrease methyl gallbladder
The ability of anthracene induced tumor.Lentinan has strong inhibitory action to cancerous cell, is to the suppression ratio of white mice sarcoma 180
97.5%, it is 80% to the suppression ratio of ehrlich carcinoma.
There is grifolan activated immune function, induction cancerous cell natural apoptosis, anticancer to grow, prevent cancerous cell
Shift, prevent normal cancerous cell canceration and anticarcinogen from sharing generation synergistic function, mitigate chemotherapeutical side effect, lure
T cell differentiation is led, human immunity is improved.
Cordycepin contained by Cordyceps can be remarkably reinforced the ability of red blood cell adhesion tumor cell, suppress growth and metastasis of tumours,
Leukocyte and platelet counts can be obviously improved, the nausea of the vomiting after chemicotherapy, poor appetite, alopecia, mistake are improved rapidly
The symptoms such as dormancy.
Herba Cichorii powder is the mixture of the natural levan of a class, inulin before Di, itself be just fermented into short-chain fatty acid and
Lactate, lactate is the regulator of liver metabolism.The membership that adds of inulin promotes small intestinal many to aminoacid, mineral and mushroom
The absorption of the materials such as sugar, these compositions be combined with each other the absorbability of promotion intestinal mucosa, incretion balance, effectively, reach
To antitumor efficacy.
A kind of antitumor Os Bovis grunniens collagen peptide compositionss as above, its step of preparation process includes：
(1) Grifola frondosa, Ganoderma, Lentinus Edodess, Cordyceps militaris (L.) Link. and Cordyceps are accurately weighed by the composition by weight, is crushed, cross 80-120
Mesh sieve, obtains fine powder；
(2) step (1) gained fine powder is added in pot for solvent extraction, is first soaked 1 hour in 65-70 DEG C of 20% ethanol water,
Ethanol water consumption is 10-20 times of the fine powder weight, is then heated to boiling, persistently boils 2-3 hours；
(3) complex liquid obtained by step (2) is filtered, is then pumped in blending vat；
(4) compound certain kind of berries oleo stock, Herba Cichorii powder, Os Bovis grunniens collagen protein peptide powder are accurately weighed by the composition by weight, adds step
Suddenly in (3) blending vat, stir 30 minutes；
(5) by step (4) resulting material by homogenization, homogenizer one-step valve 20MP, secondary valve 40MP；
(6) the material Jing pipelines sterilizing for obtaining step (5), outlet temperature 80-85 DEG C；
(7) the material pump-in pressure Centrafugal spray drying tower for obtaining step (6), 180-190 DEG C of air intake, air-out
85-90 DEG C, 60 DEG C of temperature of charge is dried and sterilizing, and a step is completed, and obtains powder；
(8) fill, using packer fill into bag；
(9) mounted box, is distributed into box, sealing；
(10) product inspection, qualified warehouse-in.
It is an advantage of the invention that：Processing method of the present invention is simple, instant, it is to avoid the nutrient that secondary operations are caused
Loss.Compound certain kind of berries oleo stock is rich in anthocyanidin, vitamin and mineral, and the addition of Herba Cichorii powder promotes intestinal to Os Bovis grunniens collagen
The absorption of the materials such as protein peptide, anthocyanidin, grifolan, Ganoderma triterpenoidss, ganoderan, vitamin and mineral, this
A little materials improve body immunity through biochemical reaction and synergism, play function of tumor inhibition.
Specific embodiment
Below by a kind of antitumor Os Bovis grunniens collagen peptide composite powder and its system in the specific embodiment narration present invention
Preparation Method, unless stated otherwise, technological means used are method known in those skilled in the art in the present invention.Separately
Outward, embodiment is interpreted as illustrative, and unrestricted the scope of the present invention, and the spirit and scope of the invention are only by right
Claim is limited.To those skilled in the art, on the premise of without departing substantially from spirit and scope of the present invention, to these
The various changes or change that material component and consumption in embodiment is carried out fall within protection scope of the present invention.
Embodiment 1
A kind of antitumor Os Bovis grunniens collagen peptide compositionss are made up of the raw material of following composition by weight：
15 parts of Os Bovis grunniens collagen protein peptide powder, 3 parts of Herba Cichorii powder, 22 parts of cranberry oleo stock, 20 parts of blueberry protoplasm, Cordyceps militaris (L.) Link. 10
Part, 10 parts of Ganoderma, 10 parts of Lentinus Edodess, 5 parts of Grifola frondosa, 5 parts of Cordyceps.
(1) Grifola frondosa, Ganoderma, Lentinus Edodess, Cordyceps militaris (L.) Link. and Cordyceps are accurately weighed by the composition by weight to crush, crosses 80-120
Mesh sieve, obtains fine powder；
(2) step (1) gained fine powder is added in pot for solvent extraction, is first soaked 1 hour in 70 DEG C of 20% ethanol water,
Ethanol water consumption is 15 times of the fine powder weight, is then heated to boiling, persistently boils 2-3 hours；
(3) complex liquid obtained by step (2) is filtered, is then pumped in blending vat；
(4) compound certain kind of berries oleo stock, Herba Cichorii powder, Os Bovis grunniens collagen protein peptide powder are accurately weighed by the composition by weight, adds step
Suddenly in (3) blending vat, stir 30 minutes；
(5) by step (4) resulting material by homogenization, homogenizer one-step valve 20MP, secondary valve 40MP；
(6) the material Jing pipelines sterilizing for obtaining step (5), 85 DEG C of outlet temperature；
(7) the material pump-in pressure Centrafugal spray drying tower for obtaining step (6), 190 DEG C of inlet temperature goes out pathogenic wind-warm
90 DEG C of degree, 60 DEG C of temperature of charge is dried and sterilizing, and a step is completed, and obtains powder；
(8) fill, using packer fill into bag；
(9) mounted box, is distributed into box, sealing；
(10) product inspection, qualified warehouse-in.
Embodiment 2
A kind of antitumor Os Bovis grunniens collagen peptide compositionss are made up of the raw material of following composition by weight：
17 parts of Os Bovis grunniens collagen protein peptide powder, 2 parts of Herba Cichorii powder, 40 parts of blackberry plasmogen, Cordyceps militaris (L.) Link. 10, Ganoderma 10, Lentinus Edodess 10
Part, 5 parts of Grifola frondosa, 6 parts of Cordyceps.
(1) Grifola frondosa, Ganoderma, Lentinus Edodess, Cordyceps militaris (L.) Link. and Cordyceps are accurately weighed by the composition by weight to crush, crosses 80-120
Mesh sieve, obtains fine powder；
(2) step (1) gained fine powder is added in pot for solvent extraction, is first soaked 1 hour in 70 DEG C of 20% ethanol water,
With 10 times that ethanol water amount is the fine powder weight, boiling is then heated to, persistently boils 3 hours；
(3) complex liquid obtained by step (2) is filtered, is then pumped in blending vat；
(4) compound certain kind of berries oleo stock, Herba Cichorii powder, Os Bovis grunniens collagen protein peptide powder are accurately weighed by the composition by weight, adds step
Suddenly in (3) blending vat, stir 30 minutes；
(5) by step (4) resulting material by homogenization, homogenizer one-step valve 20MP, secondary valve 40MP；
(6) the material Jing pipelines sterilizing for obtaining step (5), 82 DEG C of outlet temperature；
(7) the material pump-in pressure Centrafugal spray drying tower for obtaining step (6), 185 DEG C of air intake, 90 DEG C of air-out,
60 DEG C of temperature of charge, is dried and sterilizing, and a step is completed, and obtains powder；
(8) fill, using packer fill into bag；
(9) mounted box, is distributed into box, sealing；
(10) product inspection, qualified warehouse-in.
Embodiment 3
A kind of antitumor Os Bovis grunniens collagen peptide compositionss are made up of the raw material of following composition by weight：
15 parts of Os Bovis grunniens collagen protein peptide powder, 3 parts of Herba Cichorii powder, 40 parts of cranberry oleo stock, 10 parts of Cordyceps militaris (L.) Link., 10 parts of Ganoderma,
10 parts of Lentinus Edodess, 7 parts of Grifola frondosa, 5 parts of Cordyceps.
(1) Grifola frondosa, Ganoderma, Lentinus Edodess, Cordyceps militaris (L.) Link. and Cordyceps are accurately weighed by the composition by weight to crush, crosses 80-120
Mesh sieve, obtains fine powder；
(2) step (1) gained fine powder is added in pot for solvent extraction, is first soaked 1 hour in 65 DEG C of 20% ethanol water,
With 20 times of water that ethanol water amount is the fine powder weight, boiling is then heated to, persistently boils 2 hours；
(3) complex liquid obtained by step (2) is filtered, is then pumped in blending vat；
(4) compound certain kind of berries oleo stock, Herba Cichorii powder, Os Bovis grunniens collagen protein peptide powder are accurately weighed by the composition by weight, adds step
Suddenly in (3) blending vat, stir 30 minutes；
(5) by step (4) resulting material by homogenization, homogenizer one-step valve 20MP, secondary valve 40MP；
(6) the material Jing pipelines sterilizing for obtaining step (5), 80 DEG C of outlet temperature；
(7) the material pump-in pressure Centrafugal spray drying tower for obtaining step (6), 190 DEG C of air intake, 90 DEG C of air-out,
60 DEG C of temperature of charge, is dried and sterilizing, and a step is completed, and obtains powder；
(8) fill, using packer fill into bag；
(9) mounted box, is distributed into box, sealing；
(10) product inspection, qualified warehouse-in.
To antitumor evaluating drug effect：
1. laboratory animal and modeling
Regular grade ICR white mice 140, male and female half and half, body weight 18-22g；7 groups, 20 per group are randomly divided into after weighing；
Respectively：Blank group, it is positive controls, the high, medium and low dosage group of antineoplastic pharmaceutical compositions of the present invention 1, anti-swollen
2 groups of tumor compositionss, 3 groups of anti-tumor compositions.
From the S180 sarcoma tumors of well-grown 7-10 days, it was subcutaneous to be inoculated in right side of mice armpit, about 4.5-5 × 106
Cell/only.
2. Experimental agents
Positive control drug：5-FU：5-FU injection 0.5ml (12.5mg) is drawn, in adding 9ml normal saline, is matched somebody with somebody
Into the solution of 1.25mg/ml.
Antineoplastic pharmaceutical compositions 1：The antineoplastic pharmaceutical compositions prepared by embodiment 1.
Antineoplastic pharmaceutical compositions 2：The antineoplastic pharmaceutical compositions prepared by embodiment 2.
Antineoplastic pharmaceutical compositions 3：The antineoplastic pharmaceutical compositions prepared by embodiment 3.
3. test and result
After tumor inoculation 24h, in addition to blank control group, remaining group mice gives corresponding medicine.
Determine body weight during administration daily, put to death mice within the 8th day, claim knurl weight, the average knurl weight of each group is calculated, by following formula
Calculate tumor control rate.
Antineoplastic pharmaceutical compositions of the present invention affect little to S180 sarcomas Mouse Weight, but have significantly suppression to S180 sarcomas
Make and use, the results are shown in Table 1, comparing with blank control group has significant differences P ＜ 0.01.
Impact of the antineoplastic pharmaceutical compositions of the present invention of table 1 to S180 implanted solid tumor growths
P ＜ 0.01.
Claims (3)
1. a kind of antitumor Os Bovis grunniens collagen peptide compositionss, it is characterised in that be made up of the raw material of following composition by weight：
Os Bovis grunniens collagen protein peptide powder 15-25 parts, Herba Cichorii powder 2-4 parts, compound certain kind of berries oleo stock 40-50 part, Cordyceps militaris (L.) Link. 10-20 parts,
Ganoderma 10-20 parts, Lentinus Edodess 10-20 parts, Grifola frondosa 5-15 part and Cordyceps 5-15 parts.
2. a kind of antitumor Os Bovis grunniens collagen peptide compositionss as claimed in claim 1, it is characterised in that：Described answers
It is one or more in cranberry oleo stock, blueberry protoplasm, blackberry plasmogen and Fructus Fragariae Ananssae oleo stock to close certain kind of berries oleo stock.
3. a kind of antitumor Os Bovis grunniens collagen peptide compositionss as claimed in claim 1, it is characterised in that preparation technology
Step is：
(1) Grifola frondosa, Ganoderma, Lentinus Edodess, Cordyceps militaris (L.) Link. and Cordyceps are accurately weighed by the composition by weight to crush, crosses 80-120
Mesh sieve, obtains fine powder；
(2) step (1) gained fine powder is added in pot for solvent extraction, is first soaked 1 hour in 65-70 DEG C of 20% ethanol water,
With 10-20 times that ethanol water amount is the fine powder weight, boiling is then heated to, persistently boils 2-3 hours；
(3) complex liquid obtained by step (2) is filtered, is then pumped in blending vat；
(4) compound certain kind of berries oleo stock, Herba Cichorii powder, Os Bovis grunniens collagen protein peptide powder are accurately weighed by the composition by weight, adds step
Suddenly in (3) blending vat, stir 30 minutes；
(5) by step (4) resulting material by homogenization, homogenizer one-step valve 20MP, secondary valve 40MP；
(6) the material Jing pipelines sterilizing for obtaining step (5), outlet temperature 80-85 DEG C；
(7) the material pump-in pressure Centrafugal spray drying tower for obtaining step (6), 180-190 DEG C of air intake, air-out
85-90 DEG C, 60 DEG C of temperature of charge is dried and sterilizing, and a step is completed, and obtains powder；
(8) fill, using packer fill into bag；
(9) mounted box, is distributed into box, sealing；
(10) product inspection, qualified warehouse-in.
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| CN201510742382.XA CN106668841A (en) | 2015-11-05 | 2015-11-05 | Anti-tumor yak ossein protein peptide composition and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108066743A (en) * | 2018-01-26 | 2018-05-25 | 陈保国 | A kind of Chinese medicine for the treatment of cancer and preparation method thereof |
| CN108783465A (en) * | 2018-05-22 | 2018-11-13 | 湖北和格复合骨胶原生物科技有限公司 | A kind of nutrition formula product with oncotherapy function |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108066743A (en) * | 2018-01-26 | 2018-05-25 | 陈保国 | A kind of Chinese medicine for the treatment of cancer and preparation method thereof |
| CN108783465A (en) * | 2018-05-22 | 2018-11-13 | 湖北和格复合骨胶原生物科技有限公司 | A kind of nutrition formula product with oncotherapy function |
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