CN106606798A - Medical hyaluronic acid bioremediation plaster and preparation method thereof - Google Patents
Medical hyaluronic acid bioremediation plaster and preparation method thereof Download PDFInfo
- Publication number
- CN106606798A CN106606798A CN201611113430.XA CN201611113430A CN106606798A CN 106606798 A CN106606798 A CN 106606798A CN 201611113430 A CN201611113430 A CN 201611113430A CN 106606798 A CN106606798 A CN 106606798A
- Authority
- CN
- China
- Prior art keywords
- hyaluronic acid
- molecular weight
- medical
- component
- biological prosthetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 228
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 214
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 214
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000011505 plaster Substances 0.000 title abstract 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 65
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 50
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 49
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 48
- 239000008213 purified water Substances 0.000 claims abstract description 42
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 25
- 229960000458 allantoin Drugs 0.000 claims abstract description 25
- 229940069521 aloe extract Drugs 0.000 claims abstract description 25
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 24
- 235000011187 glycerol Nutrition 0.000 claims abstract description 24
- 239000001649 glycyrrhiza glabra l. absolute Substances 0.000 claims abstract description 23
- 229940051810 licorice root extract Drugs 0.000 claims abstract description 23
- 235000020725 licorice root extract Nutrition 0.000 claims abstract description 23
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims abstract description 21
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims abstract description 21
- 239000004744 fabric Substances 0.000 claims abstract description 15
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 15
- 230000000694 effects Effects 0.000 claims abstract description 11
- 229940085237 carbomer-980 Drugs 0.000 claims abstract description 8
- 208000010668 atopic eczema Diseases 0.000 claims abstract description 4
- 201000004624 Dermatitis Diseases 0.000 claims abstract description 3
- 239000007788 liquid Substances 0.000 claims abstract description 3
- 230000000474 nursing effect Effects 0.000 claims abstract description 3
- 230000029087 digestion Effects 0.000 claims description 40
- 238000006384 oligomerization reaction Methods 0.000 claims description 39
- -1 D-pantothenyl Chemical group 0.000 claims description 34
- 239000011159 matrix material Substances 0.000 claims description 24
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 20
- 229940036350 bisabolol Drugs 0.000 claims description 20
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 20
- 238000002156 mixing Methods 0.000 claims description 20
- 229920002125 Sokalan® Polymers 0.000 claims description 17
- 230000029663 wound healing Effects 0.000 claims description 16
- 239000004745 nonwoven fabric Substances 0.000 claims description 13
- 230000001954 sterilising effect Effects 0.000 claims description 11
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Natural products OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 10
- 238000010521 absorption reaction Methods 0.000 claims description 10
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 10
- 229910052782 aluminium Inorganic materials 0.000 claims description 10
- 239000011888 foil Substances 0.000 claims description 10
- 238000007789 sealing Methods 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 230000008961 swelling Effects 0.000 claims description 10
- 230000004888 barrier function Effects 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 230000002980 postoperative effect Effects 0.000 claims description 4
- 230000036299 sexual function Effects 0.000 claims description 4
- 208000020154 Acnes Diseases 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 244000020998 Acacia farnesiana Species 0.000 claims 1
- 235000003074 Acacia farnesiana Nutrition 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 230000035876 healing Effects 0.000 abstract description 13
- 208000002874 Acne Vulgaris Diseases 0.000 abstract description 6
- 206010000496 acne Diseases 0.000 abstract description 6
- 230000001815 facial effect Effects 0.000 abstract description 2
- 238000005067 remediation Methods 0.000 abstract 2
- 239000011703 D-panthenol Substances 0.000 abstract 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 abstract 1
- 235000004866 D-panthenol Nutrition 0.000 abstract 1
- 229960003949 dexpanthenol Drugs 0.000 abstract 1
- 238000001976 enzyme digestion Methods 0.000 abstract 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 abstract 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 abstract 1
- 229960002216 methylparaben Drugs 0.000 abstract 1
- 230000003716 rejuvenation Effects 0.000 abstract 1
- 230000008591 skin barrier function Effects 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 24
- 208000027418 Wounds and injury Diseases 0.000 description 14
- 206010052428 Wound Diseases 0.000 description 11
- 230000006378 damage Effects 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 4
- 230000035617 depilation Effects 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 206010053615 Thermal burn Diseases 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- 206010012435 Dermatitis and eczema Diseases 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- 241000825107 Hierochloe Species 0.000 description 2
- 235000015466 Hierochloe odorata Nutrition 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 230000012292 cell migration Effects 0.000 description 2
- 150000002016 disaccharides Chemical group 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 2
- 229940099552 hyaluronan Drugs 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 229910052979 sodium sulfide Inorganic materials 0.000 description 2
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000000451 tissue damage Effects 0.000 description 2
- 231100000827 tissue damage Toxicity 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- QQGISFDJEJMKIL-JAIQZWGSSA-N (5z)-5-[[3-(hydroxymethyl)thiophen-2-yl]methylidene]-10-methoxy-2,2,4-trimethyl-1h-chromeno[3,4-f]quinolin-9-ol Chemical compound C1=CC=2NC(C)(C)C=C(C)C=2C2=C1C=1C(OC)=C(O)C=CC=1O\C2=C/C=1SC=CC=1CO QQGISFDJEJMKIL-JAIQZWGSSA-N 0.000 description 1
- 108010022579 ATP dependent 26S protease Proteins 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 240000008632 Cota tinctoria Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 102000001974 Hyaluronidases Human genes 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 229960002773 hyaluronidase Drugs 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- JKQOBWVOAYFWKG-UHFFFAOYSA-N molybdenum trioxide Chemical compound O=[Mo](=O)=O JKQOBWVOAYFWKG-UHFFFAOYSA-N 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 229910001948 sodium oxide Inorganic materials 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a medical hyaluronic acid bioremediation plaster and a preparation method thereof; a hyaluronic acid raw liquid in the bioremediation plaster comprises the following components by the mass percentage: 0.001%-0.3% of a higher-molecular-weight hyaluronic acid, 0.001%-0.1% of a medium-molecular-weight hyaluronic acid, 0.001%-0.3% of an enzyme-digestion oligomeric hyaluronic acid, 0.01%-5% of butanediol, 1%-15% of glycerin, 0.001%-0.2% of dragosantol, 0.01%-1.5% of allantoin, 0.1%-0.8% of carbomer 980, 0.01%-0.6% of D-panthenol, 0.02%-1% of sodium hydroxide, 0.05%-5% of an aloe extract, 0.05%-3% of a licorice root extract, 0.001%-0.5% of methylparaben, and the balance purified water. The medical hyaluronic acid bioremediation plaster takes non-woven cloth or silk cloth as a substrate. The medical hyaluronic acid bioremediation plaster prepared from the hyaluronic acids with the high molecular weight, medium molecular weight and oligomeric molecular weight is applied in remediation and nursing of facial acne, eczematous dermatitis, and laser and photon rejuvenation postoperation, promotes wound surface healing, and achieves the effects of remediation and reconstruction of a skin barrier function.
Description
Technical field
The present invention relates to medical reparation field, and in particular to a kind of medical hyaluronic acid is biological prosthetic to be pasted and its preparation side
Method.
Background technology
Hyaluronic acid（Hyaluronic Acid, HA）For a kind of linear polysaccharide, by β -1,3- glucose acetamides（β-1,
3-N-acetylglucosamine）With β -1,4- gluconic acids（β-1,4-glucuronic acid）With β-Isosorbide-5-Nitrae glucosides key-shaped
Into repetition disaccharide unit, this disaccharides repetitive again with β -1,3 glycosidic bonds repeat connect, formed straight chain polymer polymer.
Hyaluronic acid can absorb the moisture of more than 500 times of relative self-molecules present amount, at the same can affect the transfer of cell, differentiation, growth,
Blood vessel transfer, immunological regulation and radicals scavenging etc..Additionally, hyaluronic acid does not have kind sex differernce, with extremely excellent life
Thing compatibility and biodegradability, in being widely used in medicine and skin care item.
Skin is the important storage vault of hyaluronic acid, while being also the important component of extracellular matrix, is maintaining skin
Form, 26S Proteasome Structure and Function aspect have important function.Almost all of tissue and liquid contain hyaluronic acid in human body, and machine
The body hyaluronic acid of more than half is enriched in epidermis and corium positioned at skin, and during skin wound healing, hyaluronic acid rises
Vital effect, is to reach one of material of wound after body injury earliest, combined with fibrinogen, in HA enzymes
The lower hydrolysis of effect, excites subsequent wound reparation until repairing completely.HA can also strengthen the effect of fibrin ferment in injury, make
For the catalyst that fibrin clot is formed.Monocytic pathology phagocytosis reaction can also be promoted simultaneously.Due to HA water conservations and hydrability
Can, by expanding intercellular space, promote signaling, bring up one and be suitable for inflammatory cell entrance and maintain its active ring
Border, exception, hyaluronic acid promotes the entrance of epidermal cell and sticks, and can also promote fibrocellular increment and migration.
The hyaluronic acid of different molecular weight has different expression ways during skin ultrastructure.Existing market product
Prepared by the hyaluronic acid of unimodal molecular weight mostly or the hyaluronic acid of several different molecular weights is arbitrarily arranged in pairs or groups, it is impossible to will be saturating
Barrier protection and repair maximization of the bright matter acid to skin.Molecular weight hyaluronic acid, the intermediate molecular weights such as Jing height of the present invention
The scientific matching of hyaluronic acid and digestion oligomerization hyaluronic acid, auxiliary in other palliative compositions, hyaluronic acid opposite is realized in perfection
The postoperative reparation of portion's acne, dermatitis and eczema, laser, photon delicate skin and nursing, promote wound healing, reach reconstruction skin
The effect of the barrier sexual function of skin.
The content of the invention
It is an object of the invention to provide a kind of biological prosthetic patch of medical hyaluronic acid for having a scientific matching, can eliminate skin
Skin inflammation, promotes wound healing, reaches the effect of the barrier sexual function of reconstruction skin.
To reach above-mentioned purpose, the present invention is employed the following technical solutions：
A kind of biological prosthetic patch of medical hyaluronic acid, including：The hyaluronic acid stoste that matrix is adsorbed with matrix.Wherein hyalomitome
Sour stoste includes the component of following percentage：The molecular weight hyaluronic acids such as 0.001%～0.3% height, decile in 0.001%～0.1%
Son amount hyaluronic acid, 0.001%～0.3% digestion oligomerization hyaluronic acid, 0.01%～5% butanediol, 1%～15% glycerine, 0.001%
～0.2% bisabolol, 0.01%～1.5% allantoin, 0.1%～0.8% Carbopol, 0.01%～0.6% D-pantothenyl aleohol, 0.02%
～1% NaOH, 0.05%～5% aloe extract, 0.05%～3% licorice root extract, 0.001%～0.5% methyl hydroxybenzoate,
Remaining is purified water.Its mesostroma is non-woven fabrics or silk fabric carrier.
The high molecular weight hyaluronic acid of the present invention has good lubricity and film forming, can be formed in skin surface
The netted hydration shell of gas, adjusts the water balance of skin and can effectively completely cut off the intrusion of the pathogen such as extraneous bacterial micro-organism；
There is intermediate molecular weight hyaluronic acid cell migration to act on, and hydrolyze in the presence of hyaluronidase, effectively facilitate tissue damage
Reparation；Digestion oligomerization hyaluronic acid can infiltrate into skin base layer, and moisturizing maintenance is provided from root, while removing excessive
Free radical, stimulate circulation, blood vessel hyperplasia and regulate and control the synthesis of collagen.The biological prosthetic patch of medical hyaluronic acid of the present invention
Using the scientific matching of high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid and digestion oligomerization hyaluronic acid, three association
Same-action, high molecular weight hyaluronic acid forms protecting film and provides wet environment, and intermediate molecular weight hyaluronic acid promotes cell
Migration and tissue damage reparation, digestion oligomerization hyaluronic acid is stimulated circulation, promotes granulation growth, accelerating wound healing energy
Power.
Butanediol is 1,3- dihydroxy butane, is one kind of polyalcohol, often makees NMF, because butanediol is that small molecule is protected
Wet composition, so water ratio very little is grabbed, while also there is certain bacteriostasis.
Glycerine is glycerine, as NMF, avoids periwound skin from suffering damage while sepage can be absorbed.
Bisabolol is a kind of composition in yellow chamomile, it is possible to provide good skin-friendliness, while with anti-inflammatory suppression
Bacterium acts on, and there is an optimum concentration, and validity is reduced on the contrary after optimum concentration.
Allantoin is 5- Allantoins, is that one kind is releived composition, can mitigate outside stimulus, improve medical hyalomitome
The skin-friendliness of sour biology maintenance patch, promotion cell growth.
Carbomer is polyacrylic resin, is common thickener.And Carbopol viscosity is higher, residual solvent is less,
Biocompatibility is more excellent.
D-pantothenyl aleohol is the NMF that can be penetrated deep into, and stimulates the growth of epithelial cell, promotes wound healing and play to disappear
Inflammation effect.
Aloe extract has skin whitening, moisturizing, antiallergy, the regeneration for promoting injury tissue and healing function.
Licorice root extract is the composition for having a medical value extracted from Radix Glycyrrhizae, and it has clearing heat and detoxicating, anti-inflammatory and anti-
Abnormal ability, can suitably alleviate allergic symptom of the only a few to hyaluronic acid autopath.
Methyl hydroxybenzoate is a kind of efficient germicide, heat-resist, and the growth to suppressing bacterial micro-organism has work well
With the holding time of the biological prosthetic patch of medical hyaluronic acid can be extended.
NaOH adjusts that medical hyaluronic acid is biological prosthetic to be labelled to skin optimal pH as antalkali.
Preferably, the hyaluronic acid stoste in the biological prosthetic patch of medical hyaluronic acid includes the component of following percentage：
The molecular weight hyaluronic acids such as 0.08% height, 0.02% intermediate molecular weight hyaluronic acid, 0.1% digestion oligomerization hyaluronic acid, 3% fourth two
Alcohol, 8% glycerine, 0.05% bisabolol, 0.2% allantoin, 0.1% Carbopol, 0.2% D-pantothenyl aleohol, 0.07% NaOH,
0.5% aloe extract, 0.5% licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
Preferably, the molecular weight of high molecular weight hyaluronic acid is more than 1800 kDa, preferably 2000 kDa；Medium molecule
The molecular weight of amount hyaluronic acid is 400 kDa～800 kDa, and preferably 680 kDa, the molecular weight of digestion oligomerization hyaluronic acid is less than
10 kDa, preferably 5600 Da.
Preferably, the matter of high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid and digestion oligomerization hyaluronic acid
Amount is than being 4:1:5.
Preferably, the matrix in the biological prosthetic patch of medical hyaluronic acid adopts non-woven fabrics or silk fabric for carrier.
Preferably, the biological prosthetic patch of medical hyaluronic acid adopts Co60 irradiation sterilizations.
Present invention also offers the preparation method of the biological prosthetic patch of medical hyaluronic acid, each distributed components and not can be made
Influence each other, the biological prosthetic patch stability of medical hyaluronic acid of preparation is optimum.
The preparation method of the biological prosthetic patch of above-mentioned medical hyaluronic acid, comprises the following steps：
Step one：By high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbomer
980 are added in appropriate purified water, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Preferably, it is 5～7, preferably 6.2 that step 3 NaOH adjusts hyaluronic acid stoste pH value.
Compared with prior art, the invention has the beneficial effects as follows：
（1）Prepared using the scientific matching of equimolecular quantity hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid
Medical hyaluronic acid it is biological prosthetic patch particular for the postoperative reparation of face acnes, dermatitis and eczema, laser, photon delicate skin and shield
Reason, promotes wound healing, reaches effect of barrier sexual function of reconstruction skin etc.；
（2）Bisabolol and D-pantothenyl aleohol are added, diminish inflammation the factor, skin permeation deep layer, stimulate epithelial cell growth, promote wound
Mouth healing；
（3）Natural aloe extract and licorice root extract is added, the biological prosthetic patch of medical hyaluronic acid is at utmost played
Repair to skin, while reducing probability of the only a few patient to hyaluronic acid allergic symptom.
（4）Allantoin is added, the skin-friendliness of the biological prosthetic patch of medical hyaluronic acid is improve, mitigates environmental stimuli thing
Bring the skin irritatin caused by skin into.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further illustrated.
Embodiment 1
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：The molecular weight hyaluronic acids such as 0.1% height, 0.1% intermediate molecular weight hyaluronic acid, 2.9% butanediol, 8% glycerine, 0.05% is red
Bisabol, 0.1% allantoin, 0.2% Carbopol, 0.2% D-pantothenyl aleohol, 0.1% NaOH, 0.5% aloe extract, 0.5%
Licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of high molecular weight hyaluronic acid is 2000 kDa；The molecular weight of intermediate molecular weight hyaluronic acid is 800
kDa。
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：High molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid and Carbopol are added to into appropriate purified water
In, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Embodiment 2
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：0.1% intermediate molecular weight hyaluronic acid, 0.1% digestion oligomerization hyaluronic acid, 2.0% butanediol, 8% glycerine, 0.05% red does not have
Medicine alcohol, 0.1% allantoin, 0.15% Carbopol, 0.2% D-pantothenyl aleohol, 0.1% NaOH, 0.5% aloe extract, 0.5% is sweet
Grass roots extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of intermediate molecular weight hyaluronic acid is 680 kDa；The molecular weight of digestion oligomerization hyaluronic acid is 8000
Da。
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：Intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbopol are added to into appropriate purified water
In, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Embodiment 3
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：The molecular weight hyaluronic acids such as 0.1% height, 0.1% digestion oligomerization hyaluronic acid, 2.0% butanediol, 8% glycerine, 0.05% red does not have
Medicine alcohol, 0.1% allantoin, 0.2% Carbopol, 0.2% D-pantothenyl aleohol, 0.1% NaOH, 0.5% aloe extract, 0.5% is sweet
Grass roots extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of high molecular weight hyaluronic acid is 2000 kDa；The molecular weight of digestion oligomerization hyaluronic acid is 5600
Da。
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：High molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbopol are added to into appropriate purified water
In, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Embodiment 4
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：The molecular weight hyaluronic acids such as 0.08% height, 0.02% intermediate molecular weight hyaluronic acid, 0.1% digestion oligomerization hyaluronic acid, 3%
Butanediol, 8% glycerine, 0.05% bisabolol, 0.2% allantoin, 0.1% Carbopol, 0.2% D-pantothenyl aleohol, 0.07% hydroxide
Sodium, 0.5% aloe extract, 0.5% licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of high molecular weight hyaluronic acid is 2000 kDa；The molecular weight of intermediate molecular weight hyaluronic acid is 680
kDa；The molecular weight of digestion oligomerization hyaluronic acid is 5600 Da.
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：By high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbomer
980 are added in appropriate purified water, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Embodiment 5
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：The molecular weight hyaluronic acids such as 0.1% height, 0.08% intermediate molecular weight hyaluronic acid, 0.02% digestion oligomerization hyaluronic acid, 3%
Butanediol, 8% glycerine, 0.05% bisabolol, 0.2% allantoin, 0.1% Carbopol, 0.2% D-pantothenyl aleohol, 0.07% hydroxide
Sodium, 0.5% aloe extract, 0.5% licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of high molecular weight hyaluronic acid is 2000 kDa；The molecular weight of intermediate molecular weight hyaluronic acid is 680
kDa；The molecular weight of digestion oligomerization hyaluronic acid is 8000 Da.
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：By high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbomer
980 are added in appropriate purified water, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Embodiment 6
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：The molecular weight hyaluronic acids such as 0.08% height, 0.1% intermediate molecular weight hyaluronic acid, 0.02% digestion oligomerization hyaluronic acid, 3%
Butanediol, 8% glycerine, 0.05% bisabolol, 0.2% allantoin, 0.1% Carbopol, 0.2% D-pantothenyl aleohol, 0.07% hydroxide
Sodium, 0.5% aloe extract, 0.5% licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of high molecular weight hyaluronic acid is 2000 kDa；The molecular weight of intermediate molecular weight hyaluronic acid is 680
kDa；The molecular weight of digestion oligomerization hyaluronic acid is 5600 Da.
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：By high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbomer
980 are added in appropriate purified water, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Embodiment 7
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：The molecular weight hyaluronic acids such as 0.02% height, 0.08% intermediate molecular weight hyaluronic acid, 0.1% digestion oligomerization hyaluronic acid, 3%
Butanediol, 8% glycerine, 0.05% bisabolol, 0.2% allantoin, 0.1% Carbopol, 0.2% D-pantothenyl aleohol, 0.07% hydroxide
Sodium, 0.5% aloe extract, 0.5% licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of high molecular weight hyaluronic acid is 2000 kDa；The molecular weight of intermediate molecular weight hyaluronic acid is 680
kDa；The molecular weight of digestion oligomerization hyaluronic acid is 5600 Da.
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：By high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbomer
980 are added in appropriate purified water, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Embodiment 8
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：The molecular weight hyaluronic acids such as 0.065% height, 0.065% intermediate molecular weight hyaluronic acid, 0.065% digestion oligomerization hyalomitome
Acid, 3% butanediol, 8% glycerine, 0.05% bisabolol, 0.2% allantoin, 0.1% Carbopol, 0.2% D-pantothenyl aleohol, 0.07% hydrogen
Sodium oxide molybdena, 0.5% aloe extract, 0.5% licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of high molecular weight hyaluronic acid is 2000 kDa；The molecular weight of intermediate molecular weight hyaluronic acid is 680
kDa；The molecular weight of digestion oligomerization hyaluronic acid is 5600 Da.
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：By high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbomer
980 are added in appropriate purified water, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
The biological prosthetic patch of 1 medical hyaluronic acid is tested to laser operation white mouse wound healing effect
Take 15 Wistar big white mouse, body weight about 120g is randomly divided into after five groups and carried out back with 6.5% sodium sulfide solution and take off
Hair is processed, and depilation area is 2.5 cm × 2 cm, normal after distilled water flushing is clean to feed 12h.Laser is used after being anesthetized with ether
Beam carries out surface of a wound cutting along depilation position, and rate of cutting is 0.5m/min, causes laser beam postoperative wound.
Reference examples：With example 1, but it is not added with hyaluronic acid.
Medical hyaluronic acid prepared by embodiment 1, embodiment 2, embodiment 3 and embodiment 4 is biological prosthetic to stick on
Each mouse back is simultaneously wound with sterile bandage, and daily dressing once, observes the last healing time of the surface of a wound（With decrustation as final healing
Point）.The results are shown in Table 1.
The biological prosthetic patch of the different medical hyaluronic acids of table 1 is to white mouse wound healing effect after laser operation
Conclusion：（1）Embodiment 1, embodiment 2, embodiment 3, embodiment 4 are compared with control group, and healing time substantially shortens, and says
It is bright：Hyaluronic acid is obviously promoted wound healing.（2）Embodiment 1, embodiment 2, embodiment 3 are using two kinds of differences point
The hyaluronic acid of son amount, wound healing time is all more than 14 days, and digestion oligomerization hyaluronic acid and high equimolecular quantity is transparent
Matter acid accounting is higher, and wound healing time is shorter.（3）The healing time of embodiment 4 is foreshortened to 12 ± 1 days, shows three kinds of differences point
The hyaluronic acid synergy of son amount, to the wound healing best results after laser operation, the hyaluronic acid of high equimolecular quantity can
Wound moist environment is kept, while forming barrier film prevents outside contamination, and the hyaluronic acid of intermediate molecular weight can promote group
The reparation of damage is knitted, digestion oligomerization hyaluronic acid is permeable to skin base layer, further repair the impaired surface of a wound.
Test 2
Three kinds of hyaluronan molecule amounts are with the impact for comparing wound healing
15 facial mild acnes and the patient with light inflammation are chosen, wherein man 5, female 10, average age 25.5
Year.Being classified as surface of a wound degree in five groups, and five groups at random does not have significant difference to ensure that experimental result has contrast value.
The medical hyaluronic acid prepared in embodiment 4, embodiment 5, embodiment 6, embodiment 7 and embodiment 8 biological prosthetic is sticked
On acne surface, sooner or later respectively once, continuously stick more than two weeks until wound healing.Statistics wound healing time, the results are shown in Table
2。
2 three kinds of hyaluronan molecule amounts of table match somebody with somebody the Healing for comparing mild acne and carrying light inflammation patient
Conclusion：The healing effect with comparison acne of different molecular weight hyaluronic acid is different, when high equimolecular quantity and digestion oligomerization
When hyaluronic acid contents are higher, healing effect is optimal, and high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid and digestion are few
The mass ratio of poly- hyaluronic acid is 4:1:When 5, as long as acne healing time 10 ± 1 days.
Test 3
Regulating and controlling effect of the biological prosthetic patch of medical hyaluronic acid to scalding healing
Take 8 Wistar big white mouse, body weight about 120g, be randomly divided into after two groups carries out back depilation with 6.5% sodium sulfide solution
Process, depilation area is 2.5 cm × 2 cm, normal after distilled water flushing is clean to feed 12h.With 80 DEG C of water after being anesthetized with ether
Scald and process 15s, and ensure that scalding area does not have notable difference.
The medical hyaluronic acid of the preparation of Example 4 is biological prosthetic to stick on each mouse back and is twined with sterile bandage
Around daily dressing once, is continuously sticked two weeks, and by table 3 its average scalding area size is recorded（It is defined by scab forming time）.
Reference examples：With example 1, but it is not added with hyaluronic acid.
Conclusion：The biological prosthetic patch of medical hyaluronic acid substantially, quickly heals to minor scald healing effect with scald wound is promoted
Conjunction ability.
Claims (9)
1. the biological prosthetic patch of a kind of medical hyaluronic acid, it is characterised in that include：The hyaluronic acid that matrix is adsorbed with matrix is former
Liquid.
2. the biological prosthetic patch of medical hyaluronic acid according to claim 1, it is characterised in that hyaluronic acid stoste include with
The component of lower percentage：The molecular weight hyaluronic acids such as 0.001%～0.3% height, 0.001%～0.1% intermediate molecular weight hyaluronic acid,
0.001%～0.3% digestion oligomerization hyaluronic acid, 0.01%～5% butanediol, 1%～15% glycerine, 0.001%～0.2% opopanax
Alcohol, 0.01%～1.5% allantoin, 0.1%～0.8% Carbopol, 0.01%～0.6% D-pantothenyl aleohol, 0.02%～1% hydroxide
Sodium, 0.05%～5% aloe extract, 0.05%～3% licorice root extract, 0.001%～0.5% methyl hydroxybenzoate, remaining is purifying
Water.
3. hyaluronic acid stoste according to claim 2, it is characterised in that including the component of following percentage：0.08% is high
Equimolecular quantity hyaluronic acid, 0.02% intermediate molecular weight hyaluronic acid, 0.1% digestion oligomerization hyaluronic acid, 3% butanediol, 8% is sweet
Oil, 0.05% bisabolol, 0.2% allantoin, 0.1% Carbopol, 0.2% D-pantothenyl aleohol, 0.07% NaOH, 0.5% aloe
Extract, 0.5% licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
4. the hyaluronic acid stoste according to Claims 2 or 3, it is characterised in that the molecule of high molecular weight hyaluronic acid
Amount is more than 1800 kDa；The molecular weight of intermediate molecular weight hyaluronic acid be 400 kDa～800 kDa, digestion oligomerization hyaluronic acid
Molecular weight be less than 10 kDa.
5. the hyaluronic acid stoste according to Claims 2 or 3, it is characterised in that high molecular weight hyaluronic acid, middle decile
The mass ratio of son amount hyaluronic acid and digestion oligomerization hyaluronic acid is 4:1:5.
6. the biological prosthetic patch of medical hyaluronic acid according to claim 1, it is characterised in that the matrix be non-woven fabrics or
Silk fabric is carrier.
7. the biological prosthetic patch of medical hyaluronic acid according to claim 1, it is characterised in that be applied to face acnes, skin
The postoperative reparation of scorching eczema, laser, photon delicate skin and nursing, promote wound healing, reach the barrier of reconstruction skin
The effect of sexual function.
8. the composition of the biological prosthetic patch of medical hyaluronic acid being based on described in claim 1, it is characterised in that preparation process is included
Following steps：
Step one：By high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbomer
980 are added in appropriate purified water, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
9. the preparation process of the biological prosthetic patch of medical hyaluronic acid according to claim 8, it is characterised in that in step 3 plus
The pH value for entering hyaluronic acid stoste after NaOH is 5～7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611113430.XA CN106606798A (en) | 2016-12-07 | 2016-12-07 | Medical hyaluronic acid bioremediation plaster and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611113430.XA CN106606798A (en) | 2016-12-07 | 2016-12-07 | Medical hyaluronic acid bioremediation plaster and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106606798A true CN106606798A (en) | 2017-05-03 |
Family
ID=58636510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611113430.XA Withdrawn CN106606798A (en) | 2016-12-07 | 2016-12-07 | Medical hyaluronic acid bioremediation plaster and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106606798A (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107007876A (en) * | 2017-06-02 | 2017-08-04 | 江苏昌吉永生物科技股份有限公司 | Hyaluronic acid medical aseptic dressing and preparation method thereof |
| CN108210887A (en) * | 2017-11-27 | 2018-06-29 | 南京天纵易康生物科技股份有限公司 | A kind of Medical cold application and preparation method thereof |
| CN108210983A (en) * | 2017-11-27 | 2018-06-29 | 南京天纵易康生物科技股份有限公司 | A kind of nasal cavity is grafted hyaluronic acid sponge and preparation method thereof with agarose |
| CN109200275A (en) * | 2018-11-23 | 2019-01-15 | 杭州炬九生物科技有限公司 | A kind of Medical cold application for micro- whole rear easing pain and diminishing inflammation promoting healing |
| CN109394675A (en) * | 2018-09-19 | 2019-03-01 | 广州睿森生物科技有限公司 | A kind of skin matrix and its preparation method and application of quick reparation skin |
| CN110151643A (en) * | 2019-04-30 | 2019-08-23 | 深圳玉莱漫生物科技有限公司 | A kind of anti-aging, the Medical cold application for repairing damaged skin and preparation method thereof |
| CN110215461A (en) * | 2019-07-04 | 2019-09-10 | 西安汇智医疗集团有限公司 | A kind of formula and preparation method of medical cosmetology product |
| CN110237091A (en) * | 2019-07-27 | 2019-09-17 | 海南希睿达生物技术有限公司 | A kind of hyaluronic acid maintenance biomembrane can be used for children |
| CN110507558A (en) * | 2019-09-20 | 2019-11-29 | 成都迪康中科生物医学材料有限公司 | A kind of hyaluronic acid mask liquid for wound repair and preparation method thereof |
| CN110585062A (en) * | 2019-09-30 | 2019-12-20 | 华熙生物科技股份有限公司 | Hyaluronic acid oral care composition and preparation method and application thereof |
| CN111714681A (en) * | 2019-03-19 | 2020-09-29 | 陕西佰傲再生医学有限公司 | Medical adhesive dressing and preparation method thereof |
| CN111714396A (en) * | 2020-07-22 | 2020-09-29 | 华熙生物科技股份有限公司 | Composition containing ectoin and application thereof in laser beauty treatment |
| CN112237552A (en) * | 2019-07-17 | 2021-01-19 | 杰途凯生物有限公司 | Skin external composition containing complex hyaluronic acid |
| CN115845112A (en) * | 2022-11-24 | 2023-03-28 | 方林健(广州)健康产业有限公司 | Medical sodium hyaluronate repair patch and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686158A (en) * | 2005-03-21 | 2005-10-26 | 凌沛学 | Adhesive bandage containing hyaluronic acid biological composition |
| CN104983647A (en) * | 2015-07-31 | 2015-10-21 | 桂林市宏旭生物科技有限公司 | Deep restoration mask and making method thereof |
| CN105194719A (en) * | 2015-10-28 | 2015-12-30 | 成都清科生物科技有限公司 | Facial wound restoration dressing and plaster, and preparation methods thereof |
-
2016
- 2016-12-07 CN CN201611113430.XA patent/CN106606798A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686158A (en) * | 2005-03-21 | 2005-10-26 | 凌沛学 | Adhesive bandage containing hyaluronic acid biological composition |
| CN104983647A (en) * | 2015-07-31 | 2015-10-21 | 桂林市宏旭生物科技有限公司 | Deep restoration mask and making method thereof |
| CN105194719A (en) * | 2015-10-28 | 2015-12-30 | 成都清科生物科技有限公司 | Facial wound restoration dressing and plaster, and preparation methods thereof |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107007876A (en) * | 2017-06-02 | 2017-08-04 | 江苏昌吉永生物科技股份有限公司 | Hyaluronic acid medical aseptic dressing and preparation method thereof |
| CN108210887A (en) * | 2017-11-27 | 2018-06-29 | 南京天纵易康生物科技股份有限公司 | A kind of Medical cold application and preparation method thereof |
| CN108210983A (en) * | 2017-11-27 | 2018-06-29 | 南京天纵易康生物科技股份有限公司 | A kind of nasal cavity is grafted hyaluronic acid sponge and preparation method thereof with agarose |
| CN109394675A (en) * | 2018-09-19 | 2019-03-01 | 广州睿森生物科技有限公司 | A kind of skin matrix and its preparation method and application of quick reparation skin |
| CN109200275A (en) * | 2018-11-23 | 2019-01-15 | 杭州炬九生物科技有限公司 | A kind of Medical cold application for micro- whole rear easing pain and diminishing inflammation promoting healing |
| CN111714681A (en) * | 2019-03-19 | 2020-09-29 | 陕西佰傲再生医学有限公司 | Medical adhesive dressing and preparation method thereof |
| CN110151643A (en) * | 2019-04-30 | 2019-08-23 | 深圳玉莱漫生物科技有限公司 | A kind of anti-aging, the Medical cold application for repairing damaged skin and preparation method thereof |
| CN110215461A (en) * | 2019-07-04 | 2019-09-10 | 西安汇智医疗集团有限公司 | A kind of formula and preparation method of medical cosmetology product |
| CN112237552B (en) * | 2019-07-17 | 2024-04-30 | 杰途凯生物有限公司 | Skin external preparation composition containing composite hyaluronic acid |
| CN112237552A (en) * | 2019-07-17 | 2021-01-19 | 杰途凯生物有限公司 | Skin external composition containing complex hyaluronic acid |
| CN110237091A (en) * | 2019-07-27 | 2019-09-17 | 海南希睿达生物技术有限公司 | A kind of hyaluronic acid maintenance biomembrane can be used for children |
| CN110507558A (en) * | 2019-09-20 | 2019-11-29 | 成都迪康中科生物医学材料有限公司 | A kind of hyaluronic acid mask liquid for wound repair and preparation method thereof |
| CN110507558B (en) * | 2019-09-20 | 2020-08-28 | 成都迪康中科生物医学材料有限公司 | A kind of wound repairing hyaluronic acid facial mask liquid and preparation method thereof |
| CN110585062B (en) * | 2019-09-30 | 2022-08-02 | 华熙生物科技股份有限公司 | Hyaluronic acid oral care composition and preparation method and application thereof |
| CN110585062A (en) * | 2019-09-30 | 2019-12-20 | 华熙生物科技股份有限公司 | Hyaluronic acid oral care composition and preparation method and application thereof |
| CN111714396A (en) * | 2020-07-22 | 2020-09-29 | 华熙生物科技股份有限公司 | Composition containing ectoin and application thereof in laser beauty treatment |
| CN115845112A (en) * | 2022-11-24 | 2023-03-28 | 方林健(广州)健康产业有限公司 | Medical sodium hyaluronate repair patch and preparation method thereof |
| CN115845112B (en) * | 2022-11-24 | 2024-07-23 | 方林健(广州)健康产业有限公司 | Medical sodium hyaluronate repair patch and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106606798A (en) | Medical hyaluronic acid bioremediation plaster and preparation method thereof | |
| CN104587518B (en) | Hyaluronic acid dressing and preparation method thereof | |
| CN105194719B (en) | A kind of facial wound repairs dressing, application and preparation method thereof | |
| CN110882207B (en) | A kind of preparation technology and method of essence for skin repair | |
| CN106822988B (en) | Alginate fiber functional dressing and application thereof, and alginate fiber functional dressing patch | |
| CN111658818A (en) | Medical repair dressing and application thereof | |
| WO2014117316A1 (en) | Multi-function aloe gel and preparation method thereof | |
| CN107496325A (en) | Facial mask containing peony essential oil, green cucumber extract solution and snail stoste and preparation method thereof | |
| CN107137760A (en) | A kind of moisturizing maintenance dressing and preparation method thereof | |
| WO2023231051A1 (en) | Antibacterial, antioxidant hydrogel dressing for treating diabetic wounds and preparation method therefor | |
| CN108478453A (en) | Hyaluronic acid face mask liquid and preparation method thereof | |
| CN108578266A (en) | A kind of antioxidant composition and its application in facial mask liquid | |
| CN106110389A (en) | A kind of moist dressing of skin wound and its preparation method and application | |
| CN105749333B (en) | A kind of hyaluronic acid medical dressing and preparation method thereof | |
| CN108261361A (en) | A kind of anti-acne repairing paste containing Porcine HGF and preparation method thereof | |
| WO2014190179A2 (en) | Urea silicon gel for scars and hydration treatment and method of using same | |
| CN104740677B (en) | A kind of skin is medical to repair dressing and preparation method thereof | |
| CN109700750A (en) | A kind of anti-ageing face mask and preparation method thereof containing sodium hyaluronate | |
| CN109700998A (en) | A kind of compound skin injury regeneration renovation agent and preparation method thereof | |
| CN113648251A (en) | Skin repairing composition and preparation method thereof | |
| CN115998940B (en) | Repairing dressing and processing technology thereof | |
| CN102988962A (en) | Composition for preventing or treating pruritus cutanea | |
| CN115282324B (en) | Silk fibroin hydrogel dressing and preparation method and application thereof | |
| CN113616587B (en) | Aerosol for repairing skin after being exposed to sun and preparation method thereof | |
| WO2023187632A1 (en) | Composition, application of the composition, cosmetic preparation hydrogel bio-mask in the form of a compress, method of manufacturing the preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170503 |