CN106591384A - Comprehensive treatment method of xylose mother liquor - Google Patents
Comprehensive treatment method of xylose mother liquor Download PDFInfo
- Publication number
- CN106591384A CN106591384A CN201611194776.7A CN201611194776A CN106591384A CN 106591384 A CN106591384 A CN 106591384A CN 201611194776 A CN201611194776 A CN 201611194776A CN 106591384 A CN106591384 A CN 106591384A
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- CN
- China
- Prior art keywords
- xylose
- mother liquid
- xylose mother
- arabinose
- mother liquor
- Prior art date
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- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 title claims abstract description 304
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 title claims abstract description 198
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 title claims abstract description 153
- 238000000034 method Methods 0.000 title claims abstract description 33
- 239000012452 mother liquor Substances 0.000 title abstract 9
- 239000007788 liquid Substances 0.000 claims abstract description 104
- SRBFZHDQGSBBOR-HWQSCIPKSA-N L-arabinopyranose Chemical compound O[C@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-HWQSCIPKSA-N 0.000 claims abstract description 45
- 239000013078 crystal Substances 0.000 claims abstract description 24
- 239000012535 impurity Substances 0.000 claims abstract description 24
- 239000011347 resin Substances 0.000 claims abstract description 24
- 229920005989 resin Polymers 0.000 claims abstract description 24
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 22
- 239000008103 glucose Substances 0.000 claims abstract description 21
- 108010015776 Glucose oxidase Proteins 0.000 claims abstract description 14
- 239000004366 Glucose oxidase Substances 0.000 claims abstract description 14
- 229940116332 glucose oxidase Drugs 0.000 claims abstract description 14
- 235000019420 glucose oxidase Nutrition 0.000 claims abstract description 14
- 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 12
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims abstract description 11
- 230000003647 oxidation Effects 0.000 claims abstract description 11
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 11
- 239000000843 powder Substances 0.000 claims abstract description 11
- 229920000642 polymer Polymers 0.000 claims abstract description 10
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims abstract description 7
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims abstract description 7
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims abstract description 7
- 239000000174 gluconic acid Substances 0.000 claims abstract description 7
- 235000012208 gluconic acid Nutrition 0.000 claims abstract description 7
- 239000000176 sodium gluconate Substances 0.000 claims abstract description 7
- 229940005574 sodium gluconate Drugs 0.000 claims abstract description 7
- 235000012207 sodium gluconate Nutrition 0.000 claims abstract description 7
- 238000001914 filtration Methods 0.000 claims abstract description 3
- 238000003756 stirring Methods 0.000 claims abstract description 3
- 238000006116 polymerization reaction Methods 0.000 claims abstract 2
- 239000000243 solution Substances 0.000 claims description 49
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 30
- 238000000926 separation method Methods 0.000 claims description 26
- 238000006243 chemical reaction Methods 0.000 claims description 18
- 239000000126 substance Substances 0.000 claims description 17
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 16
- 239000003957 anion exchange resin Substances 0.000 claims description 12
- 239000012528 membrane Substances 0.000 claims description 11
- 238000007445 Chromatographic isolation Methods 0.000 claims description 10
- 238000005119 centrifugation Methods 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- UPMFZISCCZSDND-JJKGCWMISA-M sodium gluconate Chemical compound [Na+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O UPMFZISCCZSDND-JJKGCWMISA-M 0.000 claims description 10
- 239000003480 eluent Substances 0.000 claims description 9
- 239000012530 fluid Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 238000002425 crystallisation Methods 0.000 claims description 6
- 230000008025 crystallization Effects 0.000 claims description 6
- 238000009413 insulation Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 239000003456 ion exchange resin Substances 0.000 claims description 2
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 2
- 239000010413 mother solution Substances 0.000 claims description 2
- 229920001221 xylan Polymers 0.000 claims 1
- 150000004823 xylans Chemical class 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 abstract description 14
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 238000013375 chromatographic separation Methods 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 2
- 238000001728 nano-filtration Methods 0.000 description 11
- 238000000605 extraction Methods 0.000 description 8
- 238000005342 ion exchange Methods 0.000 description 7
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 6
- 238000005349 anion exchange Methods 0.000 description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 6
- 239000000811 xylitol Substances 0.000 description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 6
- 229960002675 xylitol Drugs 0.000 description 6
- 235000010447 xylitol Nutrition 0.000 description 6
- 239000000203 mixture Substances 0.000 description 4
- NAOLWIGVYRIGTP-UHFFFAOYSA-N 1,3,5-trihydroxyanthracene-9,10-dione Chemical compound C1=CC(O)=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1 NAOLWIGVYRIGTP-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 235000009392 Vitis Nutrition 0.000 description 3
- 241000219095 Vitis Species 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 150000001450 anions Chemical class 0.000 description 3
- 239000003729 cation exchange resin Substances 0.000 description 3
- 229930182830 galactose Natural products 0.000 description 3
- 150000002972 pentoses Chemical class 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- AUTALUGDOGWPQH-UBLOVXTBSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;(2r,3s,4r)-2,3,4,5-tetrahydroxypentanal Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)C=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O AUTALUGDOGWPQH-UBLOVXTBSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229940023913 cation exchange resins Drugs 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000006911 enzymatic reaction Methods 0.000 description 2
- 238000005984 hydrogenation reaction Methods 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- 241000609240 Ambelania acida Species 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000000940 FEMA 2235 Substances 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 230000000170 anti-cariogenic effect Effects 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- 239000010905 bagasse Substances 0.000 description 1
- 230000001013 cariogenic effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/58—Aldonic, ketoaldonic or saccharic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The invention discloses a comprehensive treatment method of a xylose mother liquor. The method includes: (1) adding a flocculant into the xylose mother liquor, performing stirring and controlling the material temperature, carrying out filtering to obtain an impurity removed xylose mother liquor; (2) subjecting the impurity removed xylose mother liquor to enzymatic oxidation at 35-45DEG C by immobilized glucose oxidase resin to obtain gluconic acid-containing oxidation liquid, collecting the oxidation liquid and performing treatment to obtain sodium gluconate crystals; (3) carrying out xylose polymerization reaction on glucose removed xylose mother liquor through an immobilized xylanase bed so as to obtain a xylooligosaccharide-containing polymer liquid, collecting the polymer liquid and performing treatment to obtain xylooligosaccharide powder; and (4) conducting chromatographic separation on the xylose removed xylose mother liquor to obtain L-arabinose rich fraction, and treating the fraction so as to obtain L-arabinose crystals. The method provided by the invention separates and recovers components with high economic benefits in the xylose mother liquor one by one, realizes the effect of co-production of multiple effective components, and improves the comprehensive utilization efficiency of the xylose mother liquor.
Description
Technical field
The present invention relates to the preparation technology of xylose or xylitol, more particularly to a kind of integrated conduct method of xylose mother liquid.
Background technology
Xylose is a kind of pentose.Natural D- xyloses are present in plant with the form of polysaccharide, wherein many in corn cob
Contracting pentose content highest.Xylose can manufacture xylitol by hydrogenation.Xylitol is a kind of natural, healthy sweeting agent, sugariness
Suitable with sucrose, xylitol is not cariogenic and has anticariogenic effect, and metabolism is not adjusted by insulin, complete in human body metabolism
Entirely, can be used as the heat energy of diabetes patient.
At present the production method of xylitol is mainly chemical method, i.e., (contain 36 rich in poly-pentose using corn cob, bagasse etc.
～40% pentosan) raw material, Jing acid hydrolysis into containing xylose hydrolyzed solution, then neutralized, decolouring, ion exchange, knot
The complicated purification process such as crystalline substance isolates and purifies out xylose from hydrolyzed solution, then makes xylose generate xylose xylose chemistry hydrogenation
Alcohol.
It is above-mentioned prepare xylitol during can produce substantial amounts of xylose mother liquid, xylose mother liquid is stayed after xylose crystalline
The deeper thick liquid of color, the total sugar content of the xylose mother liquid of different manufacturers and different lot numbers is different, it is general come
Say, sugared concentration about 50～60% in xylose mother liquid, xylose, L-arabinose, glucose, galactose, mannose etc. are contained in the inside
Various saccharic compositions, wherein glucose contain 12～18% or so, and xylose contains 40～50% or so, and arabinose contains 17～23%, half
Lactose contains 0～6%.
Because the miscellaneous sugar content inside xylose mother liquid is higher, the dissolubility for causing xylose therein and L-arabinose increases
Greatly, traditional method is caused to crystallize out.At present xylose mother liquid is also failed to be used well, typically gone out with low price
Caramel color factory is sold to, the benefit of xylose alcohol production is greatly reduced, while causing the substantial amounts of wasting of resources and serious environment
Pollution.
The content of the invention
The present invention provides a kind of integrated conduct method of xylose mother liquid, is individually separated extraction and obtains sodium gluconate, oligomeric
Xylose and L-arabinose, are comprehensively utilized xylose mother liquid, improve the economic worth of xylose mother liquid.
A kind of integrated conduct method of xylose mother liquid, including：
(1) flocculant, stirring and control material temperature are added in xylose mother liquid, the xylose Jing after filtering and obtain remove impurity is female
Liquid；
(2) xylose mother liquid after remove impurity is carried out into oxydasises at 35～45 DEG C by immobilized glucose oxidase resin,
The oxidation solution containing gluconic acid is obtained, oxidation solution is collected and process is obtained gluconic acid sodium crystal；
(3) xylose mother liquid for removing glucose is carried out into xylose polyreaction by Immobilized Xylanase bed, is contained
There is the polymer fluid of oligomeric xylose, collect polymer fluid and process obtains xylo-oligosaccharide powder；
(4) xylose mother liquid for removing xylose is carried out into chromatographic isolation, obtains the fraction rich in L-arabinose, the fraction
L-arabinose crystal is obtained Jing after processing.
The mass percent concentration of total sugar is 45～60% in heretofore described xylose mother liquid, and wherein xylose accounts for total sugar
40～55%, L-arabinose accounts for the 15～25% of total sugar, and glucose accounts for the 10～25% of total sugar, and galactose accounts for the 5 of total sugar
～10%, and on a small quantity other sugared parts account for the 10～15% of total sugar.
In step (1), the impurity in xylose mother liquid is removed by flocculation, preferably, dry by sugar liquid in xylose mother liquid
0.3～1.0 addition flocculant of amount of substance degree, control material temperature is 50～80 DEG C, is stirred 20～50 minutes, is stirred
Mix rotating speed is 100～500 revs/min.
Preferably, in step (2), it is 2～6 to control xylose mother liquid by the speed of immobilized glucose oxidase resin
Times immobilized glucose oxidase resin volume/hour.Xylose mother liquid is at such speeds by immobilized glucose oxidase tree
Fat, it is ensured that the glucose in xylose mother liquid is fully converted into gluconic acid.
Preferably, in step (2), the process of oxidation solution includes：
(2-a) oxidation solution is controlled into the electrical conductivity ＜ 10us/cm of effluent by anion exchange resin；
(2-b) mass percent concentration is adopted to wash to anion exchange resin for 7～10% sodium hydroxide solution
De-, eluent is sodium gluconate solution；Sodium hydroxide solution pump into anion exchange resin volume that speed is 3～4 times/
Hour；
(2-c) eluent decolourized, concentrated, being centrifuged, being dried, being obtained gluconic acid sodium crystal.
Preferably, in step (3), the pH value of xylose polyreaction is 5～6, and temperature is 45～65 DEG C, and control removes Portugal
The xylose mother liquid of grape sugar is by Immobilized Xylanase bed volume that the speed of Immobilized Xylanase bed is 0.3～4.5 times/little
When.
Under the reaction conditions, by controlling enzyme reaction balance, enzyme reaction is made to carry out to the direction for generating oligomeric xylose, will
Xylose is the higher oligomeric xylose of economic worth, realizes the recycling to xylose in xylose mother liquid.
It is further preferred that the pH value of xylose polyreaction is 5～5.5, temperature is 50～60 DEG C, and control removes glucose
Xylose mother liquid by Immobilized Xylanase bed volume/hour that the speed of Immobilized Xylanase bed is 0.3～1 times.
Under the reaction conditions, the conversion ratio of xylose is higher.
Preferably, in step (3), the process of polymer fluid includes：
By polymer fluid by the NF membrane that molecular cut off is 100～300KD, volume ratio is obtained for 1：3～5 raffinate
With extracting solution, oligomeric xylose is rich in raffinate, concentrated, centrifugation, drying obtain xylo-oligosaccharide powder.
Jing after a membrance separation, oligomeric xylose is separated not thoroughly, more oligomeric xylose is also contained in extracting solution, further
Preferably, secondary membrance separation is carried out to extracting solution and obtains secondary raffinate and secondary raffinate, raffinate will be merged twice.
It is further preferred that it is 90～95% to control oligomeric xylose content in the raffinate after merging, in secondary raffinate
Oligomeric xylose content ＜ 5%.
Also contain unpolymerized xylose in secondary raffinate, it is further preferred that by secondary raffinate and removing glucose
Xylose mother liquid with volume ratio as 2～5:1 mixing, aggregated reaction and membrance separation, until xylose contains in the extracting solution of membrance separation
Amount ＜ 10%.
Jing after aforesaid operations, the xylose in xylose mother liquid can be fully converted into oligomeric xylose and be reclaimed, fully be gone back
Receive the recycling that L-arabinose in xylose mother liquid is also beneficial to after the xylose in xylose mother liquid.
L-arabinose is combined in extracting solution in step (3), preferably, in step (4), with pure water as eluant,
With chromatographic isolation resin as separating medium, the xylose mother liquid to removing glucose and xylose carries out chromatographic isolation, chromatographic isolation temperature
For 45～60 DEG C, eluant flow velocity is 1.5～3.0m3/h。
It is further preferred that the process of the fraction rich in L-arabinose includes：
(4-a) fraction that will be enriched in L-arabinose is concentrated to dryness amount of substance percent concentration for after 50～70%, by sugar
0.1～0.5 addition activated carbon of liquid amount of dry matter degree, control material temperature is 50～80 DEG C, and speed of agitator is 60
～150 revs/min, insulation is filtered after 20～50 minutes；
(4-b) by filtrate Jing ion exchange resin remove impurity, and be further concentrated to dryness amount of substance percent concentration for 65～
75%, Jing cooling crystallization, centrifugation, drying, obtain L-arabinose crystal.
Compared with prior art, beneficial effects of the present invention are：
(1) present invention successfully one by one separates and recovers the composition of high financial profit in xylose mother liquid, obtains various high-purity
Degree composition, realizes the effect of many effective ingredient coproduction, improves the comprehensive utilization ratio of xylose mother liquid, advantageously reduces production
Cost；
(2) balance of flexible utilization enzymatic conversion reaction, by xylose the higher oligomeric xylose of economic worth is produced.
Description of the drawings
Fig. 1 is the schematic flow sheet of the integrated conduct method of xylose mother liquid in embodiment.
Specific embodiment
The mass percent concentration of total sugar is 45～60% in the xylose mother liquid of following examples, and wherein xylose accounts for total sugar
40～55%, L-arabinose accounts for the 15～25% of total sugar, and glucose accounts for the 10～25% of total sugar, galactose account for total sugar 5～
10%, and on a small quantity other sugared parts account for the 10～15% of total sugar.The integrated conduct method of xylose mother liquid in following embodiment
Flow process is as shown in Figure 1.
Embodiment 1
(1) remove impurity：By 0.3 addition flocculant of sugar liquid amount of dry matter degree, control material in xylose mother liquid
Temperature is 50 DEG C, and speed of agitator is 100 revs/min, is incubated 20 minutes, is then filtered with flame filter press, obtains the wood after remove impurity
Sugared mother solution；
(2) separating glucose acid sodium：
A, oxydasises：Xylose mother liquid after remove impurity is pumped in immobilized glucose oxidase resin column, 40 DEG C of temperature
Under constant temperature, oxydasises are carried out, it is 3 times of immobilized glucose oxidase resin volume/hours that xylose mother liquid pumps into speed, until mistake
Till flowing out without gluconic acid in the oxydasises liquid of post, oxydasises liquid is collected, carry out ion exchange；
B, anion exchange and regeneration：Oxydasises liquid pump is entered in anion exchange resin, anion exchange is carried out, is pumped into
Speed is 6 times of anion exchange resin volume/hours, is monitored by on-line chromatograph work station, until without Fructus Vitis viniferae in effluent
Till saccharic acid；In regenerative process, first pump into 3 times of resin anion (R.A.) volume purified water and washed, collect effluent and with before
Effluent merges, and by pumping into 7% sodium hydroxide solution eluting is carried out, and the speed that pumps into of sodium hydroxide solution is 3 times of negative resins
Volume/hour, without till sodium gluconate in eluent；Eluent is obtained through subsequent concentration, centrifugation, drying steps
To gluconic acid sodium crystal, the purity of gluconic acid sodium crystal is 96.54%, and yield is 78%；
(3) separating oligomeric xylose：
A, enzymatic conversion are separated with oligomeric xylose：By the pH regulator for removing the xylose mother liquid after glucose to 5.5, fixation is pumped into
In changing the fixed bed of xylanase, volume is pumped into for 0.5 times of fixed bed volume/hour, 55 DEG C of fixed bed jacket heat-preservation, from fixation
Oligomeric xylose content is 10% in the enzymatic conversion liquid flowed out in bed, collects the effluent after enzymatic conversion, is directly entered NF membrane point
From system, raffinate is 1 with extracting liquid volume ratio:5, secondary membrance separation is carried out to extracting solution, merge raffinate twice, finally carry
Extraction raffinate oligomeric xylose content is 95.43%, and it is 40.86% that extracting solution oligomeric xylose content is 2.18%, Xylose Content, will be extracted
Liquid is by volume 3 with xylose mother liquid after glucose is removed:1 mixing, then Jing enzymatic conversions, membrance separation, until the wood in extracting solution
Sugared content ＜ 10%；
B, extraction oligomeric xylose：Add by the 0.2 of raffinate amount of dry matter degree in nanofiltration membrane separation raffinate
Plus activated carbon decolourized, ion exchange remove impurity, be finally concentrated to dryness amount of substance percent concentration to carry out spray dried after 50%
Dry, inlet temperature is 180 DEG C, and leaving air temp is 85 DEG C, and charging rate is 1m3/ h, finally obtains xylo-oligosaccharide powder, oligomeric xylose
The purity of powder is 94.32%, and yield is 93.77%；
(4) L-arabinose is separated：
A, L-arabinose are separated：Final extracting solution after by nanofiltration separation is pumped in chromatographic separation device, is with pure water
Eluant, with chromatographic isolation resin as separating medium, to nanofiltration membrane separation after final extracting solution in component separate, separate
Temperature is 55 DEG C, and separation flow velocity is 2.5m3/ h, extracting solution is separated into two fractions, and a part is based on L-arabinose
The content of fraction, wherein L-arabinose is more than 70%；Another part is the fraction based on miscellaneous sugar, collects two kinds respectively and evaporates
Point；
The extraction of b, L-arabinose：Take the fraction based on L-arabinose and measure amount of dry matter percent concentration and be
30%, the fraction is concentrated to dryness into amount of substance percent concentration for after 50～70%, by sugar liquid amount of dry matter degree
0.3 addition activated carbon, control material temperature is 60 DEG C, and speed of agitator is 100 revs/min, and insulation uses flame filter press after 30 minutes
Filter, then Jing anion-cation exchange resins remove impurity, and it is 70% to be further concentrated to dryness amount of substance percent concentration, is imported normal
Crystallization is cooled down in piezocrystallization tank, make L-arabinose crystal separate out, most after Jing centrifugation, drying process obtain L- I
Primary sugar crystal, the purity of L-arabinose crystal is 99.36%, and yield is 90.44%.
Embodiment 2
(1) remove impurity：By 1.0% addition flocculant of sugar liquid amount of dry matter degree in xylose mother liquid, thing is controlled
Material temperature degree is 80 DEG C, and speed of agitator is 500 revs/min, is incubated 50 minutes, is then filtered with flame filter press, after obtaining remove impurity
Xylose mother liquid；
(2) separating glucose acid sodium：
A, oxydasises：Xylose mother liquid after remove impurity is pumped in immobilized glucose oxidase resin column, 35 DEG C of temperature
Under constant temperature, oxydasises are carried out, it is 2 times of immobilized glucose oxidase resin volume/hours that xylose mother liquid pumps into speed, until mistake
Till flowing out without gluconic acid in the oxydasises liquid of post, oxydasises liquid is collected, carry out ion exchange；
B, anion exchange and regeneration：Oxydasises liquid pump is entered in anion exchange resin, anion exchange is carried out, is pumped into
Speed is 6 times of anion exchange resin volume/hours, is monitored by on-line chromatograph work station, until without Fructus Vitis viniferae in effluent
Till saccharic acid；In regenerative process, first pump into 3 times of resin anion (R.A.) volume purified water and washed, collect effluent and with before
Effluent merges, and by pumping into 10% sodium hydroxide solution eluting is carried out, and the speed that pumps into of sodium hydroxide solution is 4 times of negative resins
Volume/hour, without till sodium gluconate in eluent；Eluent is obtained through subsequent concentration, centrifugation, drying steps
Gluconic acid sodium crystal, the purity of gluconic acid sodium crystal is 95.87%, and yield is 79.17%；
(3) separating oligomeric xylose：
A, enzymatic conversion are separated with oligomeric xylose：By the pH regulator for removing the xylose mother liquid after glucose to 5, immobilization is pumped into
In the fixed bed of xylanase, volume is pumped into for 0.3 times of fixed bed volume/hour, 45 DEG C of fixed bed jacket heat-preservation, from fixed bed
Oligomeric xylose content is 8% in the enzymatic conversion liquid of middle outflow, collects the effluent after enzymatic conversion, is directly entered nanofiltration membrane separation system
System, raffinate is 1 with extracting liquid volume ratio:5, secondary membrance separation is carried out to extracting solution, merge raffinate twice, last raffinate
Oligomeric xylose content be 90.98%, extracting solution oligomeric xylose content be 2.25%, Xylose Content be 45.74%, by extracting solution with
It is by volume 2 to remove xylose mother liquid after glucose:1 mixing, then Jing enzymatic conversions, membrance separation, until the xylose in extracting solution contains
Amount ＜ 10%；
B, extraction oligomeric xylose：Add by the 0.2 of raffinate amount of dry matter degree in nanofiltration membrane separation raffinate
Plus activated carbon decolourized, ion exchange remove impurity, be finally concentrated to dryness after amount of substance percent concentration 50% and be spray-dried,
Inlet temperature is 180 DEG C, and leaving air temp is 85 DEG C, and charging rate is 1m3/ h, finally obtains xylo-oligosaccharide powder, xylo-oligosaccharide powder
Purity be 90.51%, yield is 90.66%；
(4) L-arabinose is separated：
A, L-arabinose are separated：Final extracting solution after by nanofiltration separation is pumped in chromatographic separation device, is with pure water
Eluant, with chromatographic isolation resin as separating medium, to nanofiltration membrane separation after final extracting solution in component separate, separate
Temperature is 45 DEG C, and separation flow velocity is 1.5m3/ h, extracting solution is separated into two fractions, and a part is based on L-arabinose
The content of fraction, wherein L-arabinose is more than 70%；Another part is the fraction based on miscellaneous sugar, collects two kinds respectively and evaporates
Point；
The extraction of b, L-arabinose：Take the fraction based on L-arabinose and measure amount of dry matter percent concentration and be
30%, the fraction is concentrated to dryness into amount of substance percent concentration after 50%, to add by the 0.1 of sugar liquid amount of dry matter degree
Plus activated carbon, control material temperature is 50 DEG C, and speed of agitator is 60 revs/min, and insulation is filtered after 20 minutes with flame filter press, so
By anion-cation exchange resin remove impurity, and it is 65% to be further concentrated to dryness amount of substance percent concentration, imports normal pressure crystallization
Crystallization is cooled down in tank, L-arabinose crystal is separated out, most after Jing centrifugations, that drying process obtains L-arabinose is brilliant
Body, the purity of L-arabinose crystal is 98.33%, and yield is 86.08%.
Embodiment 3
(1) remove impurity：By 1.0% addition flocculant of sugar liquid amount of dry matter degree in xylose mother liquid, thing is controlled
Material temperature degree is 80 DEG C, and speed of agitator is 500 revs/min, is incubated 50 minutes, is then filtered with flame filter press, after obtaining remove impurity
Xylose mother liquid；
(2) separating glucose acid sodium：
A, oxydasises：Xylose mother liquid after remove impurity is pumped in immobilized glucose oxidase resin column, temperature 45 C
Under constant temperature, oxydasises are carried out, it is 6 times of immobilized glucose oxidase resin volume/hours that xylose mother liquid pumps into speed, until mistake
Till flowing out without gluconic acid in the oxydasises liquid of post, oxydasises liquid is collected, carry out ion exchange；
B, anion exchange and regeneration：Oxydasises liquid pump is entered in anion exchange resin, anion exchange is carried out, is pumped into
Speed is 6 times of anion exchange resin volume/hours, is monitored by on-line chromatograph work station, until without Fructus Vitis viniferae in effluent
Till saccharic acid；In regenerative process, first pump into 3 times of resin anion (R.A.) volume purified water and washed, collect effluent and with before
Effluent merges, and by pumping into 8% sodium hydroxide solution eluting is carried out, and the speed that pumps into of sodium hydroxide solution is 4 times of negative resins
Volume/hour, without till sodium gluconate in eluent；Eluent is obtained through subsequent concentration, centrifugation, drying steps
Gluconic acid sodium crystal, the purity of gluconic acid sodium crystal is 96.13%, and yield is 76.61%；
(3) separating oligomeric xylose：
A, enzymatic conversion are separated with oligomeric xylose：By the pH regulator for removing the xylose mother liquid after glucose to 6, immobilization is pumped into
In the fixed bed of xylanase, volume is pumped into for 0.5 times of fixed bed volume/hour, 65 DEG C of fixed bed jacket heat-preservation, from fixed bed
Oligomeric xylose content is 12% in the enzymatic conversion liquid of middle outflow, collects the effluent after enzymatic conversion, is directly entered nanofiltration membrane separation
System, raffinate is 1 with extracting liquid volume ratio:5, secondary membrance separation is carried out to extracting solution, merge raffinate twice, last raffinate
Liquid oligomeric xylose content is 96.99%, and it is 40.01% that extracting solution oligomeric xylose content is 2.34%, Xylose Content, by extracting solution
It is by volume 5 with xylose mother liquid after glucose is removed:1 mixing, then Jing enzymatic conversions, membrance separation, until the xylose in extracting solution
Content ＜ 10%；
B, extraction oligomeric xylose：Add by the 0.2 of raffinate amount of dry matter degree in nanofiltration membrane separation raffinate
Plus activated carbon decolourized, ion exchange remove impurity, be finally concentrated to dryness after amount of substance percent concentration 50% and be spray-dried,
Inlet temperature is 180 DEG C, and leaving air temp is 85 DEG C, and charging rate is 1m3/ h, finally obtains xylo-oligosaccharide powder, xylo-oligosaccharide powder
Purity be 95.87%, yield is 92.15%；
(4) L-arabinose is separated：
A, L-arabinose are separated：Final extracting solution after by nanofiltration separation is pumped in chromatographic separation device, is with pure water
Eluant, with chromatographic isolation resin as separating medium, to nanofiltration membrane separation after final extracting solution in component separate, separate
Temperature is 60 DEG C, and separation flow velocity is 3.0m3/ h, extracting solution is separated into two fractions, and a part is based on L-arabinose
The content of fraction, wherein L-arabinose is more than 70%；Another part is the fraction based on miscellaneous sugar, collects two kinds respectively and evaporates
Point；
The extraction of b, L-arabinose：Take the fraction based on L-arabinose and measure amount of dry matter percent concentration and be
30%, the fraction is concentrated to dryness into amount of substance percent concentration after 70%, to add by the 0.5 of sugar liquid amount of dry matter degree
Plus activated carbon, control material temperature is 80 DEG C, and speed of agitator is 150 revs/min, and insulation is filtered after 50 minutes with flame filter press,
Then Jing anion-cation exchange resins remove impurity, and it is 75% to be further concentrated to dryness amount of substance percent concentration, imports normal pressure knot
Crystallization is cooled down in brilliant tank, make L-arabinose crystal separate out, most after Jing centrifugation, drying process obtain L-arabinose
Crystal, the purity of L-arabinose crystal is 99.05%, and yield is 88.78%.
Claims (10)
1. a kind of integrated conduct method of xylose mother liquid, it is characterised in that include：
(1) flocculant, stirring and control material temperature, the xylose mother liquid Jing after filtering and obtain remove impurity are added in xylose mother liquid；
(2) xylose mother liquid after remove impurity is carried out into oxydasises at 35～45 DEG C by immobilized glucose oxidase resin, is obtained
Oxidation solution containing gluconic acid, collects oxidation solution and process obtains gluconic acid sodium crystal；
(3) xylose mother liquid for removing glucose is carried out into xylose polyreaction by Immobilized Xylanase bed, is obtained containing low
The polymer fluid of xylan, collects polymer fluid and process obtains xylo-oligosaccharide powder；
(4) xylose mother liquid for removing xylose is carried out into chromatographic isolation, the fraction rich in L-arabinose is obtained, at fraction Jing
L-arabinose crystal is obtained after reason.
2. the integrated conduct method of xylose mother liquid according to claim 1, it is characterised in that in step (2), controls xylose
The speed that mother solution passes through immobilized glucose oxidase resin is 2～6 times of immobilized glucose oxidase resin volume/hours.
3. the integrated conduct method of xylose mother liquid according to claim 1, it is characterised in that in step (2), oxidation solution
Process includes：
(2-a) oxidation solution is controlled into the electrical conductivity ＜ 10us/cm of effluent by anion exchange resin；
(2-b) adopt mass percent concentration carries out eluting for 7～10% sodium hydroxide solution to anion exchange resin, washes
De- liquid is sodium gluconate solution；Sodium hydroxide solution pumps into anion exchange resin volume/hour that speed is 3～4 times；
(2-c) eluent decolourized, concentrated, being centrifuged, being dried, being obtained gluconic acid sodium crystal.
4. the integrated conduct method of xylose mother liquid according to claim 1, it is characterised in that in step (3), xylose polymerization
The pH value of reaction is 5～6, and temperature is 45～65 DEG C, and control removes the xylose mother liquid of glucose and passes through Immobilized Xylanase bed
Speed be 0.3～4.5 times of Immobilized Xylanase bed volume/hour.
5. the integrated conduct method of xylose mother liquid according to claim 1, it is characterised in that in step (3), polymer fluid
Process includes：
By polymer fluid by the NF membrane that molecular cut off is 100～300KD, volume ratio is obtained for 1：3～5 raffinate with carry
Liquid is taken, oligomeric xylose is rich in raffinate, concentrated, centrifugation, drying obtain xylo-oligosaccharide powder.
6. the integrated conduct method of xylose mother liquid according to claim 5, it is characterised in that secondary film is carried out to extracting solution
Isolated secondary raffinate and secondary raffinate, raffinate will merge twice.
7. the integrated conduct method of xylose mother liquid according to claim 6, it is characterised in that control merge after raffinate
Middle oligomeric xylose content is 90～95%, oligomeric xylose content ＜ 5% in secondary raffinate.
8. the integrated conduct method of xylose mother liquid according to claim 7, it is characterised in that by secondary raffinate with remove
The xylose mother liquid of glucose is with volume ratio as 2～5: 1 mixing, aggregated reaction and membrance separation, until in the extracting solution of membrance separation
Xylose Content ＜ 10%.
9. the integrated conduct method of xylose mother liquid according to claim 1, it is characterised in that in step (4), be with pure water
Eluant, with chromatographic isolation resin as separating medium, the xylose mother liquid to removing glucose and xylose carries out chromatographic isolation, chromatograph point
It it is 45～60 DEG C from temperature, eluant flow velocity is 1.5～3.0m3/h。
10. the integrated conduct method of xylose mother liquid according to claim 1, it is characterised in that rich in L-arabinose
The process of fraction includes：
(4-a) fraction that will be enriched in L-arabinose is concentrated to dryness amount of substance percent concentration for after 50～70%, dry by sugar liquid
0.1～0.5 addition activated carbon of amount of substance degree, control material temperature is 50～80 DEG C, and speed of agitator is 60～150
Rev/min, insulation is filtered after 20～50 minutes；
(4-b) by filtrate Jing ion exchange resin remove impurity, and it is 65～75% to be further concentrated to dryness amount of substance percent concentration,
Jing cooling crystallizations, centrifugation, drying, obtain L-arabinose crystal.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107974474A (en) * | 2018-01-09 | 2018-05-01 | 山东大学 | A kind of method of low cost production D-Tag |
| CN109180839A (en) * | 2018-09-25 | 2019-01-11 | 山东百龙创园生物科技股份有限公司 | A kind of preparation method of araboxylan |
| CN109384819A (en) * | 2018-11-14 | 2019-02-26 | 浙江华康药业股份有限公司 | The minimizing technology of xylose mother liquid impurity |
| CN111254231A (en) * | 2020-02-22 | 2020-06-09 | 浙江华康药业股份有限公司 | Method for extracting crystalline xylose from xylose mother liquor |
| CN114213215A (en) * | 2021-12-29 | 2022-03-22 | 浙江华康药业股份有限公司 | System and method for co-producing xylitol and caramel pigment by using xylose mother liquor |
| CN116516078A (en) * | 2023-06-14 | 2023-08-01 | 浙江华康药业股份有限公司 | A system and method for co-producing arabinose and xylooligosaccharides using xylose mother liquor |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101586129A (en) * | 2009-07-03 | 2009-11-25 | 重庆大学 | Method of preparing sodium gluconate from xylose crystallization mother liquor |
| CN101705253A (en) * | 2009-10-28 | 2010-05-12 | 安徽丰原发酵技术工程研究有限公司 | Method for treating xylose mother solution |
| CN102241707A (en) * | 2011-05-09 | 2011-11-16 | 浙江华康药业股份有限公司 | Method for extracting L-arabinose and preparing xylitol |
| CN101665523B (en) * | 2009-09-30 | 2015-09-30 | 济南圣泉唐和唐生物科技有限公司 | The production method of L-arabinose and D-xylose pref |
-
2016
- 2016-12-21 CN CN201611194776.7A patent/CN106591384A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101586129A (en) * | 2009-07-03 | 2009-11-25 | 重庆大学 | Method of preparing sodium gluconate from xylose crystallization mother liquor |
| CN101665523B (en) * | 2009-09-30 | 2015-09-30 | 济南圣泉唐和唐生物科技有限公司 | The production method of L-arabinose and D-xylose pref |
| CN101705253A (en) * | 2009-10-28 | 2010-05-12 | 安徽丰原发酵技术工程研究有限公司 | Method for treating xylose mother solution |
| CN102241707A (en) * | 2011-05-09 | 2011-11-16 | 浙江华康药业股份有限公司 | Method for extracting L-arabinose and preparing xylitol |
Non-Patent Citations (1)
| Title |
|---|
| 吴梧桐: "《酶类药物学》", 31 January 2011, 中国医药科技出版社 * |
Cited By (11)
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|---|---|---|---|---|
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| CN107974474B (en) * | 2018-01-09 | 2020-11-20 | 山东大学 | A kind of method for producing D-tagatose |
| CN109180839A (en) * | 2018-09-25 | 2019-01-11 | 山东百龙创园生物科技股份有限公司 | A kind of preparation method of araboxylan |
| CN109384819A (en) * | 2018-11-14 | 2019-02-26 | 浙江华康药业股份有限公司 | The minimizing technology of xylose mother liquid impurity |
| CN111254231A (en) * | 2020-02-22 | 2020-06-09 | 浙江华康药业股份有限公司 | Method for extracting crystalline xylose from xylose mother liquor |
| CN111254231B (en) * | 2020-02-22 | 2022-07-26 | 浙江华康药业股份有限公司 | Method for extracting crystalline xylose from xylose mother liquor |
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| US12006281B2 (en) | 2021-12-29 | 2024-06-11 | Zhejiang Huakang Pharmaceutical Co., Ltd. | Systems and methods for co-producing xylitol and caramel pigment by utilizing xylose mother liquid |
| CN116516078A (en) * | 2023-06-14 | 2023-08-01 | 浙江华康药业股份有限公司 | A system and method for co-producing arabinose and xylooligosaccharides using xylose mother liquor |
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Application publication date: 20170426 |