CN106573138A - Methods and apparatuses for user control of neurostimulation - Google Patents
Methods and apparatuses for user control of neurostimulation Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0492—Patch electrodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36034—Control systems specified by the stimulation parameters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61N1/02—Details
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
Described herein are methods and apparatuses for allowing a user to control a neuromodulator to modify a cognitive state being experienced by the user. The user may select a waveform ensemble from a hand-held user device having an interface, and the user may adjust the perceived intensity of the applied waveform ensemble with the user device while the waveform ensemble is being applied. Also described are methods of managing communication between the hand-held user device (such as a smartphone or the like) and a wearable neurostimulator. Methods of displaying and visually tracking and controlling the applied waveform ensemble are also described herein.
Description
Cross reference related application
The priority of each in the following U.S. Provisional Patent Application of patent application claims：Carry within 2 27th, 2014
(" the TRANSDERMAL ELECTRICAL STIMULATION SYSTEMS of U.S. Provisional Application No. 61/945,135 of friendship
FOR INDUCING PHOSPHENES”)；The U.S. Provisional Application No. 61/975,118 that on April 4th, 2014 submits to
(“TRANSDERMAL ELECTRICAL STIMULATION SYSTEMS”)；The U. S. application that on May 25th, 2014 submits to
62/002, No. 860 (" TRANSDERMAL ELECTRICAL STIMULATION SYSTEMS FOR INDUCING
COGNITIVE EFFECTS AND METHODS OF USING THEM”)；And the U.S. of the submission of on January 5th, 2015 is interim
Apply for the 62/099th, No. 960 (" METHODS AND APPARATUSES FOR USER CONTROL OF
NEUROSTIMULATION”).The full content of each is herein incorporated by reference in these applications.
Present patent application may further relate to following U.S. Patent application, and entire contents are herein incorporated by reference：
Entitled " the TRANSDERMAL ELECTRICAL STIMULATION METHODS FOR that on June 30th, 2014 submits to
The U. S. application the 14/320th, 443 of MODIFYING OR INDUCING COGNITIVE STATE ", it was required in 2013 years
Entitled " the Wearable Transdermal Electrical Stimulation Devices and that November 26 submitted to
The priority of the U.S. Patent Application No. 14/091,121 of Methods of Using Them ".
Merged by quoting
The all publications mentioned in this manual and patent application are such as each single publication or patent application
By ad hoc and the identical degree that is one by one indicated as by way of reference is merged in is come by quoting it in full
It is expressly incorporated herein.
Field
The present invention relates generally to neuroregulation, and relate more specifically to the user's control to neuroregulation and neuroregulation waveform
The method and apparatus of system.
Background
Brain is made up of neuron and other cell types in the network in connection, and it processes sense organ input, produces
Movement instruction and all other behavior of control and cognitive function.Neuron is mainly by electrochemistry pulse communication, electrochemistry pulse
The transmission signal between the cell connected in the brain region and between brain region.Neururgic noinvasive nerve is affected to adjust
Section technology can adjust neururgic pattern, and cause behavior, cognitive state, perception and the movement output for changing, and not
Need invasive process.
By the Jing craniums of scalp electrode/electricity irritation (hereinafter referred to as " TES ") of percutaneous has been used for affecting the brain of the mankind
Function.TES has been shown for improving motor control and motor learning, the memory reinforcing during improving S sleep, specification
Decision-making and risk assessment, affect sensory perception, and cause action.TES is used in various clinical practices in treatment, bag
Include the treatment of pain, weak, epilepsy and tinnitus.Although studying TES nerve stimulations so far, but existing it is used for
The method and apparatus of TES lacks the ability for allowing user's control nerve stimulation session.
Electric stimulation of the great majority with nervous system as target includes desktop or handpiece type hardware, and the hardware includes use
Family interface, electric control circuit, power supply (such as battery), leading electrode attach to the line of user and make a reservation for and/or pre-configured electricity
Stimulation protocol.The system that can be sold is limited in terms of allowing user to select TES waveforms and run the development of TES waveforms.
Additionally, the system that can be sold do not allow user's adjustment it is predetermined/electrical stimulation scheme that is pre-configured with.
Existing neuroregulation equipment and/or system (for example, TES system) are generally unworthy of standby user interface, for allowing
User selects TES waveforms and runs the user interface of TES waveforms adjusting and/or control TES waveforms, and with other users point
Enjoy TES waveforms.Method and apparatus for allowing user's control TES nerve stimulator will be beneficial.In addition, being configured to use
Family can in real time or near real-time ground select and adjust stimulus parameter and particularly such as have and be suitable for causing specific knowledge to imitate
The such as handss of the perceptive intensity of the complex stimulus waveform of the set waveform of various (for example, the 3 kinds or more kinds of) irritations answered
The user equipment for holding computing device (for example, smart mobile phone, panel computer, kneetop computer etc.) will be beneficial.This system
High-caliber effect, comfortable and facility can be allowed.For controlling the method and apparatus of TES sessions in setting daily
The self-excited system for using can be beneficial.
Accordingly, there exist the transcutaneous electrostimulation waveform to novel and useful permission user's control nerve stimulator method and
The needs of device.The invention provides this novel and useful method and apparatus.
Open general introduction
It is described herein for allowing user to receive nerve stimulation with from the menu of this therapy (" set waveform ")
The method and apparatus for selecting specific neural stimulation therapy, it can be organized by expected cognitive effect, and can include ranking
And/or classification (that is, giving a mark) information, and the intensity (for example, increasing or decreasing perceptive intensity) of control therapy, and at some
Effect is added to into ongoing therapy in situation, (such as, arouse phosphene or extend the waveform of current operation).
In general, the method and apparatus being described herein include allow user by from ranking and/or divided
Neural stimulation waveform set is selected and applied in the menu of the waveform sets of class to control nerve stimulator, to arouse specific knowledge
The method of effect.Waveform sets can be the combination of transcutaneous electrostimulation waveform.Waveform sets can induce strong and reliable
Cognitive effect, and mitigate skin irritation, pain and tissue injury.Can be according to frequency, peak strength, dutycycle, positive operation
The ratio (i.e. ' direct current percentage ratio ') of non-zero current, waveform be whether two-phase, charge unbalance, whether put including electric capacity
One or more in electric part etc. is limiting waveform.Waveform sets can continually or intermittently be applied.Perceived by user
Overall cognitive effect (effect including experiencing as dermal sensation) can be by the following waveform sets that will be discussed in detail
Perceptive intensity indicating.Perceptive intensity also refers to the effect of the intensity with regard to Consumer's Experience.For example, when change intensity
When (for example, changing one or more among frequency, current amplitude, dutycycle etc.), user can be experienced at one or more
In mode perceive intensity change, for example, such as perception skin irritation on change, in the cognitive effect of subjective experience
Change, in the change (for example, muscular tone or eyelid muscle twitch), etc. of physiologically muscle response.
In general, the method for allowing user to change cognitive state is described herein.The method can include adopting
User equipment to user is presented multiple waveform sets.User equipment can be formulated into user mutual according to being described herein and
Allow user's control.For example, user equipment can be using software, hardware, firmware or the like (including these combination), example
Such as, it is herein by performing " applying (application) " or " applying (app) " execution of the processor of control user equipment
The method of description is being configured.In general, user equipment can be included with processor and/or controller (for example, micro-control
Device processed) handheld device, including such as smart mobile phone (for example, iPhone, Android type telephone etc.), panel computer (iPad
Deng), wearable electronic (for example, Google glasses, intelligent watch etc.) or the like (including customization/special set
It is standby).The method being described herein can include allowing user to be downloaded in user equipment application.User equipment herein
It is referred to as user's computing device.User equipment can include display, processor and one or more input equipment (its
Touch screen can be included) and for the nerve stimulator equipment dressed by user and/or with the electrode group dressed by user
Part carries out the wireless communication module of wireless pairing and communication (for example, bluetooth, near-field communication etc.).
In general, application can allow user's observation to be applied to induce the waveform collection of cognitive effect by nerve stimulator
The storehouse of conjunction.The method and apparatus being described herein may be configured to allow users with user interface on a user device
Waveform sets are selected from multiple waveform sets.Method can include waveform sets to transmit to the god being worn in user's head
Jing stimulators.Method may also include the cognitive state for applying the waveform sets from nerve stimulator to change user.Nerve
Stimulation can be touched by user using user's computing device that radio communication is carried out with the nerve stimulator for being applied to user's head
Send out.The operation of the affable self-activation TES of user.For example, user circle that nerve stimulator can include passing through application by user is activated
Trigger the activity of nerve stimulator in face.
For example, the method that user changes cognitive state that allows being described herein includes：User is allowed in user equipment
On select waveform sets from multiple waveform sets；In order to apply waveform sets, the identifier of selected waveform sets or
The waveform parameter alternative one (or the two) of waveform sets is transmitted to the nerve stimulator for being worn on user's head；And allow user
The perceptive intensity of applied waveform sets is adjusted using user equipment during waveform sets are applied.
Waveform sets used herein generally include a series of waveform parameter group, and (wherein, waveform parameter group can be with
The intensity of specified current flow, frequency, dutycycle and charge unbalance percentage ratio and alternatively specified capacitance are discharged and are shaken
Width is adjusted), it together defines the stimulation protocol with tactic multiple different wave parameters, and used herein
Waveform sets can include per group of persistent period.For example, gathering waveform can include a series of 3 or more (examples
Such as, 4 or more, 5 or more, 6 or more, 7 or more, 8 or more, 9 or more, 10
It is individual or more etc.) component waveform, all wherein in component waveform or some be two-phase and with the persistent period with
And, including the predefined waveform parameter group of frequency, intensity, dutycycle and charge unbalance percentage ratio, wherein, each component
It is before at least one of waveform parameter of waveform waveform parameter and the component waveform in the series, afterwards or
The waveform parameter of before and afterwards component waveform is different.Functionally, waveform sets can be created, specific to arouse
Cognitive effect, loosens, calmness, energy etc..The example of waveform sets is described herein.
For example, any method that user is changed in the method for cognitive state that allows being described herein can include：Profit
Multiple waveform sets are presented to user with user equipment (for example, computing device)；User is allowed to select from multiple waveform sets
Waveform sets；The waveform parameter of waveform sets, the identifier of waveform sets, and/or waveform sets is transmitted to being worn on user
Nerve stimulator on head；Apply the waveform sets from nerve stimulator, to change the cognitive state of user；And
The perceptive intensity of the waveform sets that user equipment adjustment applies is allowed users with during applied waveforms set.
As it is used in the present context, the perceptive intensity of the waveform sets for applying is the cognition for stimulating, for example it is, existing expected
The cognitive perception (such as tranquil or energy) of cognitive effect and/or the perception of electrode and the stimulation applied on subjects skin,
Tingling, burning sensation, prurituss, " having the pins and needles ", muscle twitchess or anxiety etc..For example, can be adjusted by following action
Whole perceptive intensity：Change peak strength (for example, increase or decrease peak value and apply electric current), the applying electricity applied by nerve stimulator
The frequency (for example, generally increasing the frequency for applying to reduce perceptive intensity, reduce the frequency for applying to increase perceptive intensity) of stream,
To apply waveform in pulse in some or all applying capacitive discharges (also referred to as apply " short circuit " pulse, its
Generally reduce the perceptive intensity of waveform), increase or decrease dutycycle (generally increase dutycycle and increased perceptive intensity), Yi Jizeng
One or many added deduct in few charge unbalance percentage ratio (generally increasing charge unbalance percentage ratio will increase perceptive intensity)
It is individual adjusting perceptive intensity.Can cause relatively low dermal sensation in the stimulation of upper frequency, and actually be more beneficial for induction
Cognitive effect.
As mentioned, any method in these methods can allow user from being configured to arouse a class cognitive state
Waveform sets subset in select.The group of waveform sets or list can include being configured to arouse Different Cognitive effect (such as
Arouse " calmness " (for example, strengthen loosen, tranquil, clearheaded, gentle, introspection, promote induction or improve sleep quality, etc.
Deng) or arouse " energy " and (for example, generally arouse the sensation of energy, strengthen concentration power and attention；Strengthen Vigilance；Increase collection
Middle power and/or attention；Strengthen awakening；Increase the subjective sensation of energy；Increase objective physiology's energy level；Increase dynamic
Machine；Increase physiology to evoke；And cause warm somatosensory in the chest of experimenter)) waveform sets.
So, waveform can be based on the effect (broadly, tranquil and energy) aroused and is grouped, and these compared with
By other qualifiers, (degree of such as effect or is beaten at persistent period of (set waveform) session, ranking in the packet of broad sense
Point, the persistency of effect etc.) and be grouped into subgroup.Then user can manually select one or more from these classification,
It can on a user device be expressed as menu or the like, or can be based on Consumer's Experience, user preference, user's population system
Meter data etc. are produced from list and automatically selected.
In some variations, user equipment can be communicated with electrode assemblie, and can be with automatic detection electrode assemblie
With the time that nerve stimulator is attached (and/or being fully contacted with user's skin).The information can present on a user device and/
Or can be used for helping instruct user to select the waveform sets to be used.In some variations, the type of waveform sets or classification
(for example, it is desirable to cognitive effect, such as tranquil or energy) can depend on electrode type and/or electrode putting on user
Put.So, in some variations, device can be communicated with electrode assemblie, to confirm that, the type of electrode assemblie (for example fits
Configure together in " calmness " electrode assemblie for the temple and cervical region for being worn on user, or be suitable for being worn on the temple of user
Configure with " energy " electrode assemblie of mastoid region).When user's computing device (handheld device) confirms the certain kinds of electrode assemblie
During type, the subset of waveform sets related to the type of waveform sets can be represented to user, and other waveform sets can
To be hidden, do not start or cover.
So, in some variations, nerve stimulator can have been attached to user equipment sending signal, indicating electrode
Nerve stimulator and/or attached electrode are any types.In some variations, nerve stimulator (and/or electrode group
Part) extraneous information that can be communicated with regard to electrode assemblie with the user equipment of coordination electrode component, such as batch and/or system
Make data；Dimension information (for example, for different size or the head of shape)；With regard to making before the electrode that can reuse
Information；Capacitance information (that is, in the case where the pH for not exhausting electrode buffers consumable component, can be transmitted cosily
, with specific charge imbalance parameter stimulation magnitude) etc..
Any waveform sets during user also can be allowed to waveform sets carry out ranking, labelling, classification or marking
(such as experience them after), or observation made by other users ranking, labelling (for example, describing), classification, and/or
Marking.For example, in some variations, user can be allowed to or invite arrange the waveform sets in multiple waveform sets
Name or marking, and and then user equipment or system the ranking of the user of the waveform sets or marking can be stored, passed
It is defeated or store and transmit.In certain embodiments, (it is included in generation intensity when method can also be included in broadcasting waveform sets
The time point during waveform during adjustment) to made by user intensity adjustment carry out (for example, to the adjustment of perceptive intensity) beat
Divide, transmit or give a mark and transmit.When method is allowed or asks user to carry out ranking or marking, ranking can be based on user
Grade is provided；In some variations, grade can be generated as by the measurement of user physiology that (it can remember including brain
Record, heart rate, GSR etc.) or cognitive assessment automatically or algorithmically to determine (be different from user oneself report, or except
User oneself report beyond) efficacy ratings.
In general, any method in the method being described herein can also include user it is extra (for example, newly
) waveform sets download on user equipment or obtain extra (for example, new) waveform sets on a user device.
For example, waveform sets can be obtained (for example, download from internet site, shop, forum or market) from remote server,
Or can be generated by user and/or from other shared.
In any method in the method being described herein, user equipment with the ranking of display waveform set or can be beaten
Point, this select will using which kind of waveform when can be useful or helpful to user.Additionally, ranking can be used as comment
A part completed by the those of skill in the art of (or the link provided the it) TES that can be provided that.
In any modification in the modification being described herein, while nerve stimulator is just in applied waveforms set,
User can trigger predetermined effect from user equipment.During predetermined effect can be suspended, interrupts or change and carries out
Set waveform, to carry out predetermined effect.For example, user can be allowed to during applied waveforms set from user
Equipment is triggered to nerve stimulator and (for example, by starting control on a user device, such as pushed away from the touch screen on equipment
Dynamic button) interrupt signal transmission, wherein, interrupt signal interim modification waveform sets in predefined timer period
Apply.Be described herein the example of predetermined effect, but generally include it is of short duration (for example, less than several seconds, less than 3
Second, less than 4 seconds, less than 5 seconds, less than 6 seconds, less than 7 seconds, less than 8 seconds, less than 9 seconds, less than 10 seconds, less than 20 seconds etc.) waveform or
The modification of the waveform sets of current operation, the increase such as on perceptive intensity is (for example, by adjusting frequency, current amplitude, accounting for
It is empty than, charge unbalance percent etc.) the subsequent interim reduction on induction or be configured to arouse light in user
The waveform of photis.During set waveform, predetermined effect can be effectively (i.e., for triggering in restriction time point
So that the comfort level and effectiveness of predetermined effect may be very high).
For example, method can include allowing user to trigger interrupt signal to god from user equipment during applied waveforms set
The transmission of Jing stimulators, wherein, the interrupt signal waveform sets that interim modification applies in predefined timer period, and
And, wherein, interrupt signal is configured to arouse phosphene.For example, in some variations, user during applied waveforms set from
User equipment triggers interrupt signal to the transmission of nerve stimulator, wherein, interrupt signal is in predefined timer period
The waveform sets that temporarily modification applies, wherein, then interrupt signal is configured to instantaneously reduce increases (or alternatively, instantaneously
Increase and then reduce) perceptive intensity of waveform sets.
User equipment can also be configured to be in the subject's head of tram to operating the system aspects
And/or the user in terms of application apparatus (for example, electrode and nerve stimulator) provides help.For example, it is described herein
Any method in method can also include that display on a user device includes regarding for the instruction for using for nerve stimulator
Frequently.In some variations, method (and being configured to perform its device) can be configured to by real-time on a user device
Show that the image from camera allows user to observe the image of user's head to allow the user to confirm that nerve stimulator
Position.Notice that " real-time " is referred to about in real time, because may have due to signal transmission and process time necessary to some prolonging
When (for example, about might mean that in real time less than time delay in about 1 second within).
Any method and apparatus in the method and apparatus being described herein can include that the user of tracks of device uses
And/or the quantity of electrode that user has.Because electrode can be disposable and/or single quantity or low number count using
Electrode, so method and/or device can based on using and/or based on time passage, automatic conveying user's electrode is (for example,
The electrodes such as energy, calmness).For example, user can initially set up the quantity of the electrode assemblie to be transported and for based on the time
(that is, monthly ordering) and/or transport extra using (once i.e., user is from five electrode assemblies used in goods before)
Electrode assemblie threshold value.For example, after satisfaction imposes a condition (for example, user having less than 3 electrodes whenever)
User can set up the electrode that (for example, on user equipment and/or remote server) transports their predetermined quantity
Component (for example, 5 electrodes).The quantity and type of the electrode to be sent, payment information, transport preference and trigger condition can
With by user initially setting up (for example, including electrode initial number, it can alternatively be assumed to 1, zero or in " starting
Quantity in thing matching component ").The electrode assemblie to be transported can be electrode group or cantilever electrode, be included herein and retouch
Any electrode stated, including the electrode assemblie with multiple active regions.In some variations, device is (for example, for controlling user
Control logic of equipment etc.) can be based on system operation (historical information for using), by user via user equipment user
Interface provide renewal counting, and/or with telex network (for example, by send text, Email or other communication),
Come estimate or calculate total electrode that is that user has or being desired to have quantity record.So, these method or apparatus
In any method or apparatus can include estimating the quantity of the electrode that user have, and prompting purchase on a user device automatically
Buy the request of extra electrode.
In general, any apparatus and method in the apparatus and method being described herein can track nerve stimulator
User operation (for example, by tracking the use of control logic for running on a user device).The tracking can be concentrated
(for example, on long-range (" cloud ") server), or can be local in user equipment and/or nerve stimulator.For example, fill
Putting (for example, control software and/or circuit) can track user's applied waveforms set, including waveform sets type, in transmission
During set waveform to the user of perceptive intensity adjustment and any grade of relevant waveform sets from user, ranking,
Marking or comment.Tracking can alternatively include following Arbitrary Term：Measurement (for example, the perceptive intensity of measurement adjustment)；
Value is stored in memorizer (for example, being stored on user equipment and/or nerve stimulator)；And value is transmitted to controller equiment
Or transmit to remote server (for example, via the Internet).
In general, multiple waveform sets being presented can include：Indicate each waveform sets in multiple waveform sets
History use information, its can include the perceptive intensity to waveform user adjustment.
Multiple waveform sets are presented can be included：Based on the ranking, grade, labelling or marking made by other users, refer to
Show ranking, grade, labelling or marking the information of each waveform sets in multiple waveform sets.In some changes
In type, multiple waveform sets are presented can be included：Based on the ranking, labelling, grade or marking made by user, indicate many
Ranking or marking the information of each waveform sets in individual waveform sets.Can ranking, label, grade, beat
Point information include as description, if obtainable, its adopt title, the persistent period, distribution date or with regard to each
Other descriptive informations of waveform sets are annotating.
The device of any method in also illustrating herein for performing the method being described herein, described device
Including software, firmware, and/or hardware (or its combination).For example, also illustrating herein can be described as non-transient meter
The software of the readable storage medium of calculation machine, stores the fortune of nerve stimulator that can be by computing device to control to be dressed by user
One group of capable instruction, and the function that one group of instruction causes computing device to be described herein when by computing device
In any function.For example, non-transient computer readable storage medium storage can be by computing device controlling to be worn by user
One group of instruction of the operation of the nerve stimulator worn, and one group of instruction is when by computing device, can cause to process
Device：One group of waveform sets of the cognitive state for being configured to change user are presented to user；User is allowed from this group of waveform sets
One waveform sets of middle selection；Waveform sets parameter is transferred to nerve stimulator, for being applied to by nerve stimulator
The head of user；And allow user to adjust the perceptive intensity of the waveform sets applied during applied waveforms set.Process
Device can be that (such as smart mobile phone (for example, iPhone, Android type telephone etc.), tablet PC are (for example, for handheld device
IPad), wearable computer (for example, Google glasses, intelligent watch etc.) or the like) processor.
For example, the readable storage medium of non-transient computer is described herein, its storage can by computing device with
One group of instruction of the operation of the nerve stimulator dressed by user is controlled, and one group of instruction is when by computing device,
Processor can be caused：One group of waveform collection for being configured to change user cognition state is shown on the screen being connected with processor
Close；Allow user that a waveform sets are selected from this group of shown waveform sets；Waveform sets from being connected with processor
Wireless Transmitter be transferred to nerve stimulator, for waveform sets being put on by nerve stimulator the head of user；With
And start the control for being connected to processor, wherein, during applied waveforms set, user can adjust control to change applying
The perceptive intensity of waveform sets.
The group instruction can also cause processor when by computing device：User is allowed from by every in by waveform sets
Waveform sets are selected in the waveform sets subset that the cognitive state that one waveform sets are aroused is grouped.Group instruction by
Reason device is also possible that processor when performing：The letter that indicating electrode has been attached to nerve stimulator is received from nerve stimulator
Number.
For example, one group of instruction is also possible that processor when by computing device：Receive from nerve stimulator and indicate electricity
Pole has been attached to the signal of nerve stimulator；And the type of electrode is determined according to the signal from neural sensor.Such as
Discussed above, the group is instructed when by computing device, can also cause processor to allow user to enter the waveform sets transmitted
Row classification, labelling, ranking or marking, and In Grade, labelling, ranking or give a mark and stored, transmitted or stored and passed
It is defeated.
For example, user can provide effect with regard to gathering waveform, comfortable or effect and the comfortable feedback marking of the two
(numerical value or otherwise), but ranking may not necessarily be carried out to the waveform and other waveforms.However, user can also or
Alternatively waveform is classified compared to other waveforms (for example, it be labeled as liking and/or marking or labelling be provided
For " holding up thumb/thumb down " etc.).One group of instruction is also also possible that processor allows user to see when by computing device
Examine and/or download new waveform sets (for example, from remote server).
In some variations, the group instruction also causes processor to be displayed in this group of waveform sets when by computing device
The grade of waveform sets, ranking or marking.
As mentioned above, any device or equipment in these devices or equipment can also be configured to permit user's choosing
Select and perform (during transmission waveform sets, even if or in some modifications when waveform sets are not transmitted) pre-
The effect for first determining.For example, one group of instruction can also allow for user's handle during applied waveforms set when by computing device
Interrupt signal is transferred to nerve stimulator, wherein, interrupt signal interim modification waveform collection in predefined timer period
The applying of conjunction.For example, the group is instructed when by computing device, be can also allow for user's handle during applied waveforms set and is interrupted
Signal transmission to nerve stimulator, wherein, interrupt signal interim modification waveform sets in predefined timer period
Apply, to arouse phosphene.The group is instructed when by computing device, can also allow for user's handle during applied waveforms set
Interrupt signal is transferred to nerve stimulator, wherein, then interrupt signal is configured to instantaneously reduce increases (or be instantly increased so
Reduce afterwards) perceptive intensity of waveform sets.
Any device in these devices can also be configured to assist in user operation equipment, including set up and/or apply
Electrode.For example, one group of instruction, when by computing device, can cause processor to show including for using nerve stimulator
Instruction video.The group instruction, when by computing device, can cause processor to show in real time and derive from and processor
The image of the camera of connection so that user can observe the image of the head of user.
The group instructs the quantity that processor can be caused to estimate the electrode that user has automatically when by computing device simultaneously
And point out user to buy extra electrode.The group instruction can cause processor tracking to be applied by user when by computing device
Waveform sets, including adjustment of the user to perceptive intensity.The group instruction can cause processor to refer to when by computing device
Show the past use information of each waveform sets in this group of waveform sets, including tune of the user to the perceptive intensity of waveform
It is whole.Group instruction also cause processor based on the grade, label, ranking made by other users when by computing device or
Give a mark to indicate the information of the grade, label, ranking of each waveform sets in this group of waveform sets or marking.
The group instruction can cause processor and be indicated based on the ranking made by user in this group of waveform collection when by computing device
Grade, label, ranking or marking the information of each waveform sets in conjunction.
The method and dress of communication of the control between wearable nerve stimulator and user equipment are also illustrated herein
Put, it allows user to practise the high-level interaction and control of the transmission of nerve stimulation, including according to being configured for transmitting
Perceptive intensity is adjusted into the waveform sets for arousing cognitive state, and allows user's selection or selected, ranking and in some feelings
The waveform sets that will be transmitted are changed in condition.In modification, wherein, device is to include wearable nerve stimulator (having electrode)
With user equipment (such as, the handheld device with processor, for example, be configured to control nerve stimulator smart mobile phone) be
System, control device (user equipment) can first with nerve stimulator " pairing ", and user equipment and nerve stimulator it
Between set up safe radio communication.The communication can be radio frequency (for example, bluetooth, Zigbee, UWB etc.) or other (light
, ultrasound etc.).Once establishing communication, can confirm that communication is in carries out middle mode.If in user equipment and nerve stimulation
Confirmation between device is lost or is degraded less than threshold value, then nerve stimulator can enter standby mode or " shut " mode", and this can be with
Prevent it is further stimulate and can to optimize safe mode in the case of not excessive disruption nerve stimulation under perform.Example
Such as, if nerve stimulator unit loses the communication of the user equipment for matching before, can gradually turn down stimulation and stop until stimulating
Only.Prompting (for example, the push prompting in application) on a user device can point out user to terminate stimulating and and equipment
Release pairing.This after the connection with user equipment is lost is automatically switched off the important security feature of behavior representation, to guarantee
Nerve stimulator keeps the state that can be controlled by user equipment, including the control to stopping, suspending or reduce stimulus intensity.
In some variations, control device (for example, user equipment) can be to nerve stimulator offer rule (for example, per 400 milliseconds
Or faster) train of pulse of instruction, it can include the perception to nerve stimulation of parameter or reference and user of waveform sets
The adjustment of intensity.In that way it is possible to particularly importantly checking communication was not only sane but also correct, to avoid the unsuitable adjustment of intensity
And/or apply incorrect or unsuitable waveform.For this reason, in some variations, user equipment and nerve
Stimulator can exchange (and in some predetermined modifications) two-way or unidirectional confirmation signal of multicycle, and it can be
It is duplex or semiduplex.Some or all in communication can be with encrypted, including salt adding and hash (salting and
hashing).Specifically, can to control communication (for example, waveform sets information and/or to apply waveform adjustment) enter
Row coding, including error correcting coding etc..
For example, it is described herein and nerve stimulator is controlled to change the cognitive state of user using user equipment
Method, the method includes：During the stimulation cycle, by the very first time interval waveform sets parameter from user equipment wirelessly or
Nerve stimulator is transferred to periodically；By the second time interval less than very first time interval in a user device from nerve stimulation
Device wirelessly receives confirmation signal；And if user equipment is not received by confirmation signal, then stop transmitted waveform set ginseng
Number.
In some variations, degrade less than threshold value magnitude, nerve thorn if losing the communication with user equipment or communicating
Sharp device can stop (or oblique deascension) electricity irritation.In general, nerve stimulator may be at constant (although between discrete
Every) communication, and can be by user equipment control, it can allow user equipment to provide the real-time or near reality of nerve stimulator
When (in several seconds) control.
Any method in the method being described herein can also provide adopt user equipment control nerve stimulator with
Just the method for changing the cognitive state of user, the method includes：Indicating electrode is received from nerve stimulator in a user device
Attach to the signal of nerve stimulator；During nerve stimulation, it is spaced by the very first time, waveform sets parameter from user equipment
Transmit wirelessly and periodically to nerve stimulator；By the second time interval less than very first time interval in a user device
Confirmation signal is wirelessly received from nerve stimulator；And if user equipment is not received by confirmation signal, then stop transmission
Waveform sets parameter.
For example, in these methods any method (or being configured to perform their device) can be according to from nerve
The signal (for example, energy, calmness, lot number etc.) of stimulator determines the type of electrode.Any method in these methods can also
Including applying nerve stimulation from nerve stimulator to user using the lumped parameter received from user equipment, and/or set in user
Standby middle receipt source is in the signal of the contact of the instruction between user and the electrode of nerve stimulator of nerve stimulator.
In some variations, these methods can include that in a user device receipt source exists in the instruction of nerve stimulator
The signal of the contact between user and the electrode of nerve stimulator, wherein, the signal for indicating contact is coded in from nerve
In the confirmation signal of stimulator.
Method can also include in a user device receipt source in nerve stimulator instruction (or being associated with) in user
And the signal of the impedance between the electrode (or electrode group) of nerve stimulator, wherein, about per minute (or in some modifications
In, lower frequency or higher frequency) receive the signal for once indicating impedance.In some variations, method can include：Such as
Fruit impedance (or relating value) is higher than predefined threshold value, then stop or suspend to stimulate by nerve stimulator.
In general, during stimulating, by the very first time interval lumped parameter from user equipment wirelessly or periodically
Be transferred to nerve stimulator, can include between certain time period interval (for example, 10 milliseconds to 10 seconds, 100 milliseconds extremely
5 seconds, 200 milliseconds to 1 second, 300 milliseconds and 500 milliseconds, about 400 milliseconds etc.) hop waveform sets parameter.For example, exist
It is spaced by the very first time during stimulation and the waveform sets parameter from user equipment wirelessly or is periodically transferred to nerve
Stimulator, can be included with about 400 milliseconds of interval transmission portion waveshape lumped parameter.
The second time interval by being spaced less than the very first time is wirelessly received really in a user device from nerve stimulator
Recognize signal, can include in a user device every about 300 milliseconds, 250 milliseconds, 200 milliseconds, 150 milliseconds, 100 milliseconds, 50 millis
Second, etc. receive a confirmation signal.
The method being described herein can also include：In transmission before the waveform sets parameter of user equipment,
User equipment and nerve stimulator are matched.
As mentioned above, in any modification in these modifications, user equipment and nerve stimulator can be encrypted in
Between transmission.For example, encryption can include：Before waveform sets parameter from user device transmissions to nerve stimulator,
(or vice versa for encryption waveform sets parameter；Encryption is transmitted to the information of user equipment from nerve stimulator).
In general, reception and registration is also illustrated herein with regard to neural stimulation scheme (set waveform is also referred to as waveform sets)
Selection information particularly effective method, and to allow user to be readily seen that perceptive intensity and for comfort level and having
How effect property can adjust method of the mode of perceptive intensity to show the neural stimulation scheme of selection.Also illustrate herein
It is configured to perform the device (including software and user interface) of any method in these methods.
For example, the cognition that experimenter is changed using the nerve stimulator of the head for being worn on experimenter is described herein
The method of state, the method includes：Show on wearable and/or hand-held user equipment and will be transmitted by nerve stimulator
The expression of the maximum perceptive intensity of waveform sets；When waveform sets are put on user, it is allowed to which user adjusts from user equipment
The perceptive intensity for being applied of the waveform sets applied by nerve stimulator；And in the maximum perceptive intensity of waveform sets
Expression on show adjusted applying perceptive intensity expression.
Showing the expression of the maximum perceptive intensity of the waveform sets that will be transmitted by nerve stimulator can include that display will
The expression of the maximum perceptive intensity of the whole waveform sets to be transmitted by nerve stimulator.For example, the entire set waveform of display
The pattern of similar experience intensity is represented during the full duration that (or will) be applied can be shown as.It is aobvious
Show it can is figure or explanatory.Showing can be based on such as perceptive intensity (or maximum/perceptive intensity of peak value).
For example, display can be based on according to set waveform (for example, based on peak point current, frequency, current imbalance percent, Yi Jizhan
Sky ratio) time shafts of the value of perceptive intensity (for example, perceive instantaneous) that calculate are (linear or radial) shows.Example
Such as, perceptive intensity (or maximum perceptive intensity) can be calculated as electric current x (11000/ frequency) x (0.5+ charge unbalance percentages
Than/200) x (dutycycle/100).
For example, showing can include the expression of maximum perceptive intensity to be shown as linear display, wherein, for waveform sets
The expression of maximum perceptive intensity be arranged to the form of line.Alternatively, the maximum that can include whole waveform sets is shown
The expression of perceptive intensity is shown as ring, wherein, the expression of the maximum perceptive intensity of the starting point of waveform sets and the end of waveform sets
The expression of the maximum perceptive intensity of point is adjacent to show.
In any modification in these modifications, user can adjust the perceptive intensity being currently running (for example, in the phase of applying
Between).For example, it is allowed to which the step of user adjusts the perceptive intensity of the applying of waveform sets can be included in the display of user equipment
Upper presentation control, to adjust the perceptive intensity of applying.The perceptive intensity for being applied that user adjusts waveform sets is allowed to wrap
Include：When user adjusts downwards applied perceptive intensity, with the intensity that first rate lowers waveform；And when user is to rise
During whole applied perceptive intensity, with the intensity that the second speed raises waveform；Wherein, first rate is faster than the second speed.For example,
In some variations, can have in fixed time period (that is, in 10 seconds be not more than 1 milliampere, in 20 seconds be not more than 1
Milliampere, be not more than in 5 seconds 1 milliampere, be not more than in 1 second 1 milliampere etc.) restriction of great intensity can be increased.At some
In modification, there is the block for some time periods after increasing with the maximum, or in each unit interval limit
System increases to the limiter of the amount.User's adjustment can more rapidly be produced and reduce intensity, however, still can with restricted,
Prevent from reducing other waveform parameters (for example, frequency, dutycycle and electric charge injustice of electric current and/or impact perceptive intensity immediately
Weighing apparatus percentage ratio) because the perceptive intensity for stimulating is lowered too much and/or too soon may be uncomfortable.However, usually not
The block that the perceptive intensity of stimulation is lowered, and the maximum rate for lowering is usually faster than the maximum rate for raising.
For example, the cognition that experimenter is changed using the nerve stimulator of the head for being worn on experimenter is described herein
The method of state, the method includes：In multiple time intervals, showing in hand-held consumer devices will be passed by the nerve stimulator
The expression of the transient peak perceptive intensity of the waveform sets passed；When waveform sets are put on user, it is allowed to user by from
Control on user equipment selects or adjust the percentage ratio of peak value perceptive intensity to be come from user equipment to adjust by nerve stimulator just
In the perceptive intensity for being applied of the waveform sets for applying；And when waveform sets are applied, in each time interval in waveform
The expression of adjusted perceptive intensity is shown in the expression of the transient peak perceptive intensity of set.
As discussed above, show the moment that can include showing the whole waveform sets that will be transmitted by nerve stimulator
The expression of peak value perceptive intensity.For example, showing can include the expression of transient peak perceptive intensity to be shown as linear display, its
In, the expression for the transient peak perceptive intensity of waveform sets is arranged to the form of line.In some variations, display can be with
Expression including the transient peak perceptive intensity whole waveform sets is shown as ring, wherein, the moment of the starting point of waveform sets
The expression of peak value perceptive intensity is adjacent to show with the expression of the transient peak perceptive intensity of the terminal of waveform sets.
As mentioned above, it is allowed to which the perceptive intensity of the applying of user's adjustment waveform sets can be included in user equipment
Slider bar or rotating disk are presented on display, to adjust the perceptive intensity of applying.In some variations, user can be pressed using a pair
Button (one is used to increase, and one is used to reduce) is adjusting perceptive intensity.In any modification in the modification being described herein,
User equipment and/or nerve stimulator may be configured such that the acquiescence of user's adjustment of the perceptive intensity for waveform sets
Value or initial value.Default value or initial value can be identicals (i.e. from the perceptive intensity of waveform sets for all users
Value 50%), or default value or initial value can for user be based on before transmission by with and the user-association
The adjustment made during (for example, the ID related to the data for tracking and store) that system is tracked and stored set waveform and
Customization.Default value or initial value can be based on demographic, psychographic, and/or physiology data for user
And be customized.During set waveform stimulates, user's adjustment can be to electric current, frequency, electric current and frequency or following appoint
The adjustment of meaning combination：Electric current, frequency, dutycycle, charge unbalance percent (it is alternatively referred to as DC percentage ratios) and amplitude are adjusted
The presence of system and waveform shape.
For example, it is allowed to which the perceptive intensity for being applied of user's adjustment waveform sets can include：When user adjusts downwards institute
During the perceptive intensity of applying, with the intensity that first rate lowers waveform；And when user adjusts upward applied perceptive intensity
When, with the intensity that the second speed raises waveform；Wherein, first rate is faster than the second speed.
Brief description
The novel feature of the present invention has carried out special statement in ensuing claim.The present invention characteristic and
Being better understood from of advantage will be obtained by reference to the specific embodiment of exemplary embodiment set forth below, wherein using sending out
Bright principle, and accompanying drawing is：
Figure 1A and Fig. 1 D illustrate for induce the electrode of attention, Vigilance or the cognitive state concentrated first
Place the approximate region of configuration.
Figure 1B is shown schematically for enhanced attention, Vigilance or the second placement of the electrode concentrated is matched somebody with somebody
The approximate region put.
Fig. 1 C and Fig. 1 E illustrate the approximate of another placement configuration of the electrode of the mental status for strengthening calmness or loosening
Region.
The one embodiment of Fig. 2A -2B according to the disclosure, it is schematically shown TES waveforms.
Fig. 3 A according to one embodiment of present invention, illustrate an example of nerve stimulator.
Fig. 3 B-3G illustrate another example for the nerve stimulator being described herein.
Fig. 3 H-3K illustrate the first example of a modification of an electrode assemblie for being configured to " calmness " electrode assemblie.
Fig. 3 L-3o illustrate the second example of a modification of an electrode assemblie for being configured to " energy " electrode assemblie.
Fig. 3 P are illustrated can be worn on the head, and/or head and cervical region of experimenter to induce the electrode group of cognitive effect
The application of part.
Fig. 3 Q illustrate the nerve stimulator equipment of the head for being worn on experimenter.
Fig. 4 each embodiment of the invention, schematically shows the system to the control of nerve stimulation for user.
Fig. 5 A illustrate the user interface for allowing user's registration account and logon account.
Fig. 5 B are illustrated allows user as user name and to select user circle of password using his/her E-mail address
Face.
Fig. 6 A illustrate the user interface for allowing user to match user's computing device and nerve stimulator.
Fig. 6 B are illustrated allows user to select nerve stimulator to be connected to the user interface of user's computing device.
Fig. 6 C show that when setting up connection application program can point out user.
Fig. 6 D show that when connection is successfully established application program can notify user.
Fig. 7 illustrates according to one embodiment of present invention the user interface of the subset that each cognitive effect is presented.
Fig. 8 A some embodiments of the invention, illustrate the multiple ripples being presented in the subset of " calmness " of application program
The example of the user interface of shape set.
Fig. 8 B some embodiments of the invention, illustrate the multiple ripples being presented in the subset of " energy " of application program
The example of the user interface of shape set.
Fig. 8 C illustrate the example of the user interface for multiple waveform sets being shown as playlist of application program.
Fig. 9 A illustrate the example for reminding user to check the user interface whether head machine (electrode assemblie) correctly connects.
Fig. 9 B illustrate showing for the user interface for showing user using the history of the nerve stimulator with specific collection waveform
Example.
Figure 10 A some enforcements of the invention are exemplified and allow user that the ripple for applying is controlled during waveform sets are applied
The example of the user interface of shape set.
Figure 10 B some enforcements of the invention are exemplified and allow user that the ripple for applying is controlled during applied waveforms set
Another example of the user interface of shape set.
Figure 10 C other enforcements of the invention are exemplified and allow user to control what is applied during applied waveforms set
Another example of the user interface of waveform sets.
Figure 10 D are to show another example (similar to shown display in Figure 10 A-10B), and it is illustrated will be by
The display of the maximum perceptive intensity of the waveform sets of nerve stimulator equipment (dotted line) transmission, also show the sense of the applying of adjustment
Know intensity (solid line)；Maximum perceptive intensity is expressed as the bar of circular arrangement, with show at center, remaining for waveform sets
The remaining time.
Figure 10 E are another examples for showing, it shows the waveform sets that will be transmitted by nerve stimulator equipment most
Big perceptive intensity (dotted line), wherein illustrating the perceptive intensity (solid line) of the applying of adjustment above maximum perceptive intensity；Most
Big perceptive intensity is expressed as a winding displacement or bar.
Figure 10 F and Figure 10 G illustrate with regard to being divided into the time cycles such as 100 in a modification set waveform after handle
One modification of set waveform is shown as the maximum perceptive intensity of the display (Figure 10 G) of radial display (Figure 10 F) and figure
Display a modification.User's modification or adjustment perceptive intensity can mark and draw the top shown at these.Set waveform
The modification be 20 minutes long " energy " set waveform.
Figure 10 H and Figure 10 I illustrate with regard to being divided into the time cycles such as 100 in a modification set waveform after handle
One modification of set waveform is shown as the maximum perceptive intensity of the display (Figure 10 I) of radial display (Figure 10 H) and figure
Another modification.User's modification or adjustment perceptive intensity can mark and draw the top shown at these.Gather being somebody's turn to do for waveform
Modification is 16 minutes long " calmness " set waveform.
Figure 11 A illustrate the user interface for allowing user's selection ranking and sharing waveform sets (or its ranking).
Figure 11 B illustrate the user interface for allowing user to submit response to.
Figure 11 C illustrate another example for the user interface for allowing user to share his/her experience with friend.
Figure 11 D illustrate that permission user comes and friend via Facebook, Google+, Twitter, Email or text
Share another example of the user interface of his/her experience.
Figure 11 E illustrate that the estimation of the electrode for showing user is supplied and allows user to adjust the user interface of the estimation.
Figure 11 F illustrate the user interface of the order service for providing a user with automatic conveying electrode.
Figure 12 some embodiments of the invention, show for user by controlling waveform sets come to nerve stimulation
The flow chart that device is controlled.
Describe in detail
Each embodiment of the following description of the present invention is not intended to limit the invention to these embodiments, but makes this
Any technical staff in field can manufacture and use the present invention.
The method and apparatus being controlled to neural stimulation waveform for user is described herein (including equipment and is
System), particularly for transcutaneous electrostimulation (TES) waveform user's control method and apparatus.In general, the method, device
Electricity irritation control neuroregulation can be allowed users with system, to induce having on cognitive function and/or cognitive state
Profit or desired change.In general, user can dress neuroregulation equipment, and apply one using neuroregulation equipment
Or multiple waveforms are inducing cognitive effect.In general, user can control wearable neuroregulation equipment by user equipment.
User equipment can be used to control the waveform (" set waveform ") for being applied for transcutaneous electrostimulation scheme.System can include can
Wearing neuroregulation equipment and the user's computing device for controlling transcutaneous electrostimulation (TES) waveform.
System description
In general, the neural modulation system being described herein can set including light wearable nerve stimulator
Standby (nerve stimulator), it is configured to be worn on head and is consumable/disposable electrode assemblie；In addition, bag
Equipment (" user equipment ") including processor and wireless communication module, being held by user's wearing and/or user can be used to control
The nerve stimulation that system is applied by wearable nerve stimulator.Although the configuration and operation sense herein especially to user equipment is emerging
Interest, but the disclosure may also benefit from whole system possible feature and aspect (including nerve stimulator related to this
And/or electrode assemblie) briefly describe.
Herein user equipment is alternatively referred to as controller, and controller (user equipment or user's computing device) generally with
Nerve stimulator is separated but communicated with nerve stimulator.For example, in some variations, controller can be with nerve stimulator without
The user equipment of line communication.In some variations, controller be mobile telecommunication apparatus (for example, smart mobile phone or panel computer) or
Wearable electronic (for example, Google glasses, intelligent watch etc.), it passes through to send instruction and exchange with nerve stimulator
The application of two-way communication signals is being controlled.Any embodiment in these embodiments can be described as handheld device, because they
Can be gripped in user's handss or be worn on the body of user.However, can equally use the user equipment of non-hand-held control
(for example, desktop computer etc.).User equipment can be the common apparatus (for example, smart mobile phone) for running application software, described to answer
The user equipment concrete configuration is used as into controller with software, user equipment or can be equipment for customizing, its by it is concrete (and
And may be exclusively) be configured to and the nerve stimulator that is described herein is used together.For example, controller can be software,
Hardware or firmware, and can include being downloaded so as in (that is, by the bluetooth) equipment (example that can wirelessly connect by user
Such as, the handheld device of such as smart mobile phone or panel computer) on run application program, with allow user select by nerve stimulation
The waveform of device transmission, including allow the nerve stimulation that modulated in real time is transmitted to change the cognitive shape of the user being described herein
State.
For example, system can be operable to induce " calmness " mental status or " energetic " mental status.This is operated to be
Unite with the state for inducing the energy of increase can alternatively be described as it is following in one or more：Strengthen concentration power and attention
Power；Strengthen Vigilance；Increase concentration power and/or attention；Strengthen awakening；Increase the subjective sensation of energy；Increase objectively raw
Energy level of science；Increase motivation；Increase physiology to evoke；And arouse warm somatosensory in the chest of experimenter.
The mental status for operating the system to induce enhanced tranquility or loosen can alternatively be described as it is following in one kind
Or it is various：Tranquility in start TES sessions about 5 minutes；The carefree state of spirit；Carefree spiritual shape
State；Sleep derivation；Auxiliary is fallen asleep；Improve sleep quality；Slow down the perception of time passage；Loosening all muscless；Enhanced concentration；Suppression
System is divert one's attention；It is enhanced cognitive clear；It is enhanced to feel clear；Splitting status；Calomel poisoning；Euphoric state；Relaxation state；Strengthen
Audio experience and visual experience enjoyment；The physiology of reduction evokes；The process emotion or the ability of other stressors of increase；
The reduction that the psychophysiology related to the movable change of hypothalmus-pituitary-adrenal axis evokes；Stress, anxiety and spirit
The reduction of the biomarker of obstacle；Anxiety；Spiritual clearly state；Enhanced physical performance；To stress recovery
Power；The somatosensory for loosening of periphery；And the consciousness of sensation heartbeat.
For example, in order to strengthen energy, electrode assembly can be attached to the temple of user and in ear's (example of user
Such as, mastoid region) rear.In order to induce enhanced tranquility, electrode to be attached to the temple of user and in user
Cervical region rear portion.In both embodiments, nerve stimulator can apply to gather waveform about 2-30 minutes (for example, 3-
30 minutes, 4-30 minutes, 5-30 minutes, 2-35 minutes, 2-40 minutes, 2-45 minutes, 2-50 minutes, 2-55 minutes, 2-60 point
Clock is more long), the set waveform is made up of different " blocks " with repetitive pattern feature；Waveform sets can be included in not
Transitional region between same block.In general, in waveform block at least some (and is in some variations their big portion
Divide or whole) generally have>5 milliamperes (for example, between 5 milliamperes and 40 milliamperes, between 5 milliamperes and 30 milliamperes, at 5 milliamperes
And between 22 milliamperes etc.) current amplitude and>750 hertz (for example, between 750 hertz and 25 KHz, at 750 hertz
And 20 between KHz, between 750 hertz and 15 KHz etc.) frequency, electric current be typically two-phase and typically
Charge unbalance, and between 10-99% (for example, between 20-95%, between 30-80%, in 30-60%
Between etc.) dutycycle.One or more features in these features can be during stimulating as every several seconds to per a few minutes
The time scale of clock and change.In some cases, parameter quickly can change (that is, in hundreds of millisecond of time scale).
In addition, tiltedly change can be included in the transition of any parameter value so that the component of waveform sets continuously changes.
When being worn, system can be tested with being attached at as shown similar to the system shown in Fig. 3 Q
The electrode assemblie at two positions on the head and/or cervical region of person (point or region) place and it is attached to the nerve thorn of electrode assemblie
Sharp device；In some variations, detached controller can be attached the applying to coordinate to stimulate.
As will be described in further detail herein, nerve stimulator can be it is light (for example, less than 30 grams, it is little
In 25 grams, less than 20 grams, less than 18 grams, less than 15 grams etc.) and self-contained, such as closed circuit, power supply and radio communication
Part such as rechargeable battery and charging circuit, Bluetooth chip and antenna, microcontroller, it is configured to in 10 seconds sums
Persistent period between ten minutes transmits the current source of waveform.Nerve stimulator can also include safety circuit.Nerve stimulator
Can also include for determining that electrode is attached and electrode " species " is (that is, for tranquil pattern or energy model；Or indicate
The batch of manufacture and/or source) circuit.Fig. 3 A and Fig. 3 B-3G illustrate two kinds of modifications of nerve stimulator.
For example, Fig. 3 A illustrate the first example of nerve stimulator as described in this article.In figure 3 a, nerve thorn is shown
Sharp utensil has the electrode of paired attachment.The main body 603 of the direct-coupling TES applicators 602 of first electrode 601, and second is electric
Pole 606 connects the main body 603 of applicator 602 by cable or wire 604.These electrodes are separated from each other, and can replace
Change/disposable.Electrode of different shapes 607 can be used for the reusable nerve stimulator of identical.In this example
Nerve stimulator include the hard outer main body that can be attached of paired electrode, its via one or more type of plug company
Connect device and produce electrical contact.
Fig. 3 B-3G illustrate another preferred embodiment of nerve stimulator as described in this article.In the modification, god
Jing stimulators are also light wearable nerve stimulator, its electrodes attached, and including for two on electrode
(or possible more) electro-active region (for example, anode region and cathode zone) produces the contact of electrical connection.However,
In the example, nerve stimulator is configured to be operated together with cantilever electrode device, and be configured to in nerve stimulator
The electrode assembly in the region of offset from center was not only attached mechanically but also electrically on bottom (downside or towards skin side), this permission
One end regions is firmly held in skin and other marginal areas are not pinned in this way.Therefore, i.e., convenient electrode group
Part (can be flexible) is firmly held when skin, and " floating " end can also somewhat be adjusted to the differently curved of head.
Therefore, the cantilever attachment means can strengthen the comfort level and adjustment capability of equipment.In addition, nerve stimulator equipment can be had
Even body is configured in the glasses of user's wearing, it is also allowd to fit comfortably in the temple of user.For example, should
Device may be configured so that towards skin side (it is connected to electrode assemblie via one or more adapters) and bend to
The surface for somewhat becoming to be recessed with the angle somewhat reversed.The curved shape can be with aid-device more closely (preferably)
Adapt to temporal surface.In addition, (end is arranged to the ear pair of the edge with eyes of user and user for one end of equipment
Together) can (for example, less than 2 centimetres, less than 1.5 centimetres, less than 1 centimetre, less than 0.8 centimetre etc.) thinner than opposite end, Ke Yi
Get Geng Gao is worn on temple.
For example, Fig. 3 B-3G respectively illustrate before the modification of nerve stimulation apparatus (nerve stimulator or electrostimulator),
Afterwards, the perspective view of left side, right side, top and bottom, the nerve stimulation apparatus can be used together with cantilever electrode device.Nerve thorn
The global shape of sharp device can be triangle, and be more particularly suitable for connection electrode device and towards the nerve stimulation of patient
Device surface (despite bending/spill and torsion) can be three sides (for example, being probably triangle).It is this
Generally the shape of triangle can include circular edge, and stimulator thickness (with the table for contacting cantilever electrode device
On the vertical direction in face) can change, for example, along a side and especially along by the direction of ear from eye
The side (part between orbital border and auricle edge) that the edge of eyeball is extended transversely with is relatively thin.When contribute to assembling/
Be worn on most people face/head tend to not with hair region in when, this shape can also be beneficial
's.Both the binding agent and electric conductivity hydrogel in active electrode area can be covered on the skin with little or no hair more
Effectively work.This thin relatively low turning (socket of the eye week/ear turning) can match between eyebrow and head hair line, while compared with
Wide portion is disposed in the top of the prefrontal area that can not possibly wherein have hair.
In Fig. 3 B-3G, as shown in Fig. 3 Q, the position of object wearing device marked neural thorn according to experimenter
Each edge of sharp device.In general, the unit dressed is auricle edge towards the side of ear, during wearing on forehead
Highest side is top edge, and side during wearing near eyes/eyebrow is socket of the eye circumferential edges.The entirety of nerve stimulator
Shape is triangle (including circular edge).As shown, triangle as used herein includes having three sides
Between circle/smooth transition shape.Surface towards experimenter is specifically contoured, with by predefined direction
Assembling so that experimenter is difficult or impossible to misapply and take a risk that the active region of the cantilever electrode device of attachment is placed on into mistake
Where.When cantilever electrode device is attached to into nerve stimulator, cantilever electrode device can be with warpage or bending so that it is
The surface of contoured bent with matching and torsion.The surface is the section of saddle type shape, wherein there is curvature axis and torsion
Shaft axis, are bow around the surface of the curvature axis, and the torsion axis can make curved surface distort (two axles
Line can be with similar and different).
In housing, any nerve stimulator in the nerve stimulator being described herein can include processor (example
Such as, microprocessor) or controller and the wireless communication module and power supply (for example, battery etc.) of processor connection.Power supply can
Be configured to internally circuit and/or when user dresses between the anode region and cathode zone of electrode driving current electricity
Road provides electric power.Power supply can be high voltage power supply, for example, can provide up 60V through these electrode terminals.In general,
Device may also comprise the circuit for being configured to the energy (for example, electric current) of specification transmission in processor requirement, and this can anti-mistake
To be received from controller via wireless communication module and instruct.Controller can also pass on information, and especially with regard to the letter of electrode
Breath, include validating that electrode assemblie be connection and/or attached electrode assemblie type (for example, calmness, energy, manufacturer/
Model/size, batch etc.), and (for example, impedance is proportional to impedance or root with designator that the skin of user is contacted
The value of the estimation of electrode impedance can be obtained according to it).
As will be described in further detail herein, electrode assemblie can mechanically and/or electrically connect neural thorn
Sharp device, for example, by the nerve stimulator being buckled at one or more (for example, two) adapters of such as buckle receptor
Downside.So, in some variations, nerve stimulator can be maintained at (user's) head of experimenter by electrode assemblie
Portion；Electrode assemblie can adhesively connect the head and/or cervical region of user and be connect with forming electricity with the desired region on user
Touch, and nerve stimulator can such as adhesively and/or electrically connection electrode component.It is as described below, in nerve stimulator
Adapter and electrode assemblie between can be arranged in specific and predetermined position, described specific and predetermined position
Allow nerve stimulator be firmly attached electrode assemblie and therefore connect user head/neck and do not upset connection, and
Simultaneously permission system is worn on a variety of bodily forms.
Electrode assemblie has hereinafter carried out general detailed description together with specific example and modification.Especially, at this
Electrode assemblie described in text be it is thin (for example, typically less than 4 millimeters, less than 3 millimeters, less than 2 millimeters, less than 1 millimeter etc.
Thick, this can not include the thickness of the adapter that can be extended out from thin electrodes component) and flexibility, and can be
Flat (for example, being formed in the planes).For example, they can be printed on flexible material, such as printing flexibility
The material of circuit.In use, they can around head parcel so that its at least two positions (for example, in temple and
The rear portion of cervical region and/or the rear in ear) contact.Electrode assemblie can include adapter (electric and/or machinery), should
Adapter extends out from the surface of other flat/plane so that the active region of electrode assemblie is connected to nerve stimulator.
For example, nerve stimulator can be by being mechanically connected and electrically connecting from anterior one or more buckles for extending of electrode assemblie.
In some instances, one snaps connection by circular the first active electrode region (anode region or cathode zone) of binding agent,
So that active region adheres to the head of user.The second electrode region on the detached part of electrode assemblie is (anode or cloudy
Pole) other adapters can be electrically connected.For example, the second electrode region may adapt to be assemblied in it is in mastoid, receiving
The region of (energy electrode configuration) or the cervical region through the user at the base portion of hair line on the region at the ear rear of examination person
On, such as the region (tranquil electrode configuration) near the center line of cervical region.
Electrode assembly can be printed (for example, by flexible printing, the laser printing using electrically conductive ink, silk screen printing
Deng) in flexible plastic substrates (flexible substrates), and also can include with the electrode towards skin relative to side on into
To adapter (buckle).Electrode activity region on the rear portion of component can include conductor layer (for example, silver), in the conductor
Ag/AgCl layers are deposited as the layer sacrificed and serve as pH buffers on layer.The hydrogel layer for closing on covers Ag/AgCl electrodes, makes
Obtaining it through active region can equably be transferred to electric charge in skin.The part around active electrode area of electrode assemblie can
With with the binding agent allowed with the skin good contact of user.
As the above mentioned, there may be the various configurations (for example, shape) of electrode assemblie, also, as herein
It is more fully described, electrode assemblie generally can be formed and mechanically and electrically on flexible material (' flexible circuit ' material)
It is connected to nerve stimulator gas.
Fig. 3 H-3K illustrate a modification of cantilever electrode device (" electrode assembly "), and it can be together with nerve stimulator
Use, and can be worn on the head of experimenter.The modification is referred to alternatively as " calmness " configuration, because it is suitably connected to
The rear portion of the cervical region in the temple region and user of user.In this example, cantilever electrode device 100 includes multiple electrodes portion
It is divided to (illustrate two) 103,105.In Fig. 3 H, it is shown that front perspective view.Above for when worn away from the side of experimenter.
Cantilever electrode device is thin so that electrode portion point includes that front side (visible in Fig. 3 H and Fig. 3 I) and rear side (can in Fig. 3 K
See).As the side view in Fig. 3 J shows that equipment has thin main body, it includes electrode part 103,105 and in two electrodes
The elongation body region 107 extended between part.Elongation main body is also that thin (it has the diameter more much bigger than thickness and high
Degree).Thickness is shown in Fig. 3 J.
In this example, (electric connector and mechanical connector are shown as in this example card to two adapters 115,117
Button) extend from the front portion of cantilever electrode device.The front portion of the first electric part 103 can also include optional foam and/or glue
Condensation material 121, is stretched out by buckle its described from first electric part.First electric part its shape and size are manufactured into
So that buckle will be connected with the plug (port, bracket, opening, concave type matching etc.) on electrostimulator.As described above, adapter
Can be separated between about 0.6 inch and about 0.9 inch (for example, between about 0.7 inch and about 0.8 inch etc., in figure
Show to be for about 0.72 inch in 3H-3K).Second electrode part may also comprise foam or support section 123.The foam/support area
Domain can be optional.In some variations, interval between connectors is not limited to 0.7 to 0.8, and can more greatly (for example,
Between 0.7 inch and 1.2 inches, between 0.7 inch and 1.1 inches, between 0.7 inch and 1.0 inches, in 0.7 English
It is very little and 0.9 inch between etc.) or it is less (for example, between 0.2 inch and 0.7 inch, between 0.3 inch and 0.7 inch,
Between 0.4 inch and 0.7 inch, between 0.5 inch and 0.7 inch, between 0.6 inch and 0.7 inch etc.).
Fig. 3 K are shown the rearview of first example of cantilever electrode device.In this example, first electrode portion
Points 103 and second electrode part 105 be also shown, and comprising active region 133,135.Active region is bordered in binding agent 140.
First electrode part 103 includes the first active region 133, in the first active region 103 on the back of the body (contact patient) side
Divide and defined by binding agent 140, such as whole circumference of the part in the first active region 103, or at least in circumference
A part on.Active region may include conductive of material (for example, electrical conductivity colloid).Similarly, second electrode part 105
Back include the second active region 135, the second active region 135 on two side faces by binding agent 140 around to electrode side
Edge.Binding agent can releasedly retain the material in the binding agent that any biology on skin mixes.
Fig. 3 L-3o illustrate another example of cantilever electrode device.The example is very similar to what is shown in Fig. 3 H-3K
Modification, but be properly termed as " energy " configuration because it be configured to by head area not only contacted user temple region but also
Region of the contact behind user ear.Adapter (buckle 417,415) in such as the same position as shown in Fig. 3 H-3K,
The shape of first electrode part 403 and foam/gasket material 421 (it can also or be alternatively jointing material) is also identical.
The advantage that multiple electrodes equipment is of similar shape is set to be that they are convertibly used with single nerve stimulator device.
However, the example shown in Fig. 3 L-3o includes different global shapes, and can be used for connecting such as patient head/neck
The zones of different in portion.Specifically, the elongation body region 407 for being formed in extension between two electrode parts 403,405 of substrate
Partial shape it is slightly different.In this example, cantilever electrode device can be configured to for example by the temple of experimenter with
First electrode part (nerve stimulator may be connected thereto) connects, and it is with can surrounding subject's head curved to extend body region
It is bent so that the region electrical contact behind second electrode part and experimenter ear (for example, at lug or near lug).Pass through
First active region 433 of first electrode part 405 is positioned to make electrical contact with the skin in temple region, and by making
With the jointing material 440 around electro-active region 433 electroactive area (and nerve stimulator of attachment) is firmly held in and is received
Position on the skin of examination person, the second electro-active region can also be attached ground 441 and be held in skin so that the second electroactive area
Domain 435 contacts with head area.
In general, connecting the elongation body region of two electrode parts can have any suitable length, but generally ratio
Several inches long (for example it is, long than 2 inches, longer than 3 inches, longer than 4 inches, longer than 5 inches, longer than 6 inches, longer than 7 inches, compare 8
Inch is long, longer than 9 inches etc.).As shown in two modifications in Fig. 3 H-3K and Fig. 3 L-3o, elongation body region can also be by
It is bending or bending.For example, as shown in Fig. 3 P and Fig. 3 Q, wherein elongation main body even can be in the curved of the doubling with
Song, or material flexes or bending can be allowed, to allow its adjustable ground to be located on the head of experimenter and/or around experimenter
Head.
Fig. 3 P show the cantilever electrode device being worn in subject's head (with the electrode shown in Figure 1A and Fig. 4 A
Device is similar to).As directed, device is oriented to make first electrode part adhesively attach at temple region and makes
Two electrode parts are attached in the region of head rear (for example, at ear or neck area rear, not showing).Nerve stimulator
(not showing in Fig. 3 P) can be attached to cantilever electrode device before or after it is applied to experimenter.Show in Fig. 3 P
In the example shown, electrode assembly is energy reversal, and on the temple region for being shown as being attached at experimenter and in ear
In region (not shown) below.As shown in Fig. 3 Q, nerve stimulator by be snapped on the adapter of protrusion and can be with
The front side of cantilever electrode device is attached to, and is extended body region 107 and is curved to be extended behind simultaneously in the head of experimenter
And the part on the center line at the rear portion for extending downward the cervical region of patient.First electrode part and second electrode part can be with
The electric active regions for propping up skin are adhesively held in, this allows nerve stimulator to apply energy, and particularly such as exists
Entitled " the TRANSDERMAL ELECTRICAL STIMULATION METHODS FOR that on June 30th, 2014 submits to
The application 14/320 of MODIFYING OR INDUCING COGNITIVE STATE ", the waveform described in 443, and this application are led to
Cross reference to be entirely expressly incorporated herein it.
In use, user can be with controller (for example, by the smart mobile phone of application software/firmware control) interaction, should
Controller is matched with nerve stimulator (for example, by bluetooth).User can with operational control device with selection operation pattern, for example,
The type (for example, energy model or tranquil pattern) of the cognitive effect that will be induced, and/or equipment can be attached based on device
To the configuration of electrode automatically detect pattern.For example, user can select the set ripple to be performed from one group of set waveform
Shape.There may be detached waveform to arouse desired experience/effect (for example, the set waveform of " calmness " or " energy ").Collection
Close waveform generally can be between about 3-90 minutes (for example, between about 3-60 minutes, between about 5-60 minutes, about
Between 5-40 minutes etc., between about 3-25 minutes etc.) it is long or more long (for example, more than 3 minutes, more than 5 minutes, it is big
In 10 minutes, more than 12 minutes etc.).In general, gather waveform can with specific pulse parameter (i.e. current amplitude, frequency,
Dutycycle, charge unbalance, short circuit dischange/capacitive discharge, Modulation and Amplitude Modulation etc.) and section is broken down into, and these parameters
New section can be changed to them and in advance specific time change；Transition period can be included, with special in block
Property between change.Once user have selected set waveform, they can start nerve stimulation and user can use controller
(that is, the application program run on smart mobile phone) control changes perceptive intensity (for example, by the user interface of application program
Element is by changing up or down perceptive intensity), suspend or stop session.In general, perceptive intensity can be using can be with
Control (such as one or more buttons, the slip presented on the controller (for example, smart mobile phone) communicated with nerve stimulator
Bar, rotating disk, trigger etc.) by user, in target perceptive intensity, (for example, target current, frequency, dutycycle, charge unbalance, amplitude are adjusted
System, and/or short circuit dischange/capacitive discharge) 0-100% between scale.Controller can also allow for user's activation and (" press
Need ") it is designed to arouse the contoured configuration of predetermined response.For example, control device may adapt to show one or more icons
With the reinforcing of triggering phosphene or the cognitive effect for perceiving or dermal sensation intensity.Additionally, controller may be configured to permit
Family allowable presses icon, to contribute to using electrode assembly and/or nerve stimulator.For example, activating this control can cause intelligence
Can mobile phone Activate Phone on front-facing camera to help user that device is attached to into head.Ession for telecommunication or session it
Afterwards, user can enter help screen, the overview page, social shared interface (that is, pushing away special (tweet) your experience), with regard to meeting
The feedback of words and previously used analysis/history.In general, system can also be configured to pass data to control
Device and/or nerve stimulator transmit the data from controller and/or nerve stimulator and pass data via the Internet
It is handed to data of the remote server/transmission from remote server.These data can include user profile, Wave data, pass
Information of function or state in hardware device or electrode assemblie etc..
In general, described herein is to can be used to arousing, strengthen or changing the general of various cognitive states
TES waveform parameters.Although apparatus and method described herein can be used to providing TES and various be recognized with inducing and/or changing
Know state, describe two specific examples in detail herein, including induce enhanced attention, Vigilance or concentrate
The mental status that is tranquil with induction or loosening.Especially describe in detail be exclusively used in strengthen attention, Vigilance or concentrate and
Induction is tranquil or the configuration of the apparatus and method of the mental status loosened, including for causing the particular configuration of neuroregulation, institute
State the cognitive effect that neuroregulation is realized in these specific cognition effects in experimenter.
Therefore, the general nerve stimulator for changing cognitive state may include paired electrode (or two arrays of electrodes, example
Such as, for convenience, one is referred to alternatively as " anode ", and one is " negative electrode "), it can put on the given zone of experimenter's body
Domain, and stimulate for the TES in effectively relative high intensity, high-frequency range as described herein for providing.Generally exist
Apply electric current between anode electrode and cathode electrode (or groups of anode electrode and cathode electrode).Specifically do not operated
In the case of theory constraint, electric current can pass through body between the anode and cathode, potentially will in suitable therapeutic scheme
Energy is applied to nervous tissue's (cranial nerve, brain etc.) of the lower floor in specific nervous pathway to cause desired target to be imitated
Should (for example it is to be noted that power, Vigilance or concentrate-or induction is tranquil or the mental status loosened).Therefore, electrode is in experimenter
Placement location on body is very important to providing desired cognitive effect.It is specifically designed for the electrode of desired cognitive effect
Placement schemes or configuration are referred to alternatively as to the placement location of (anode electrode and cathode electrode).For example, be referred to alternatively as " configuration A " or
First placement configuration of the cognitive state for inducing attention, Vigilance or concentrating of " configuration 2 ", receives including putting on
The close temple region of examination person (for example, eyes side, such as slightly above right eye and on the right side of right eye or slightly above left eye and on a left side
Eye left side) first electrode and existing with the first electrode of head area (for example, in mastoid process or close mastoid process) after ear
The second electrode of the same side.Figure 1A and Fig. 1 D illustrate the approximate region placed for electrode in the configuration (configuration A, " energy ").
In the modification, first electrode 10,302 is disposed in temple, and second electrode 11,303 be disposed in experimenter 15,
Head area after 300 ear.High intensity TES in the region stimulates (being described in detail below) can cause enhanced attention
Power, Vigilance are concentrated.Figure 1B schematically show for enhanced attention, Vigilance or concentrate another match somebody with somebody
Put.(for example, second configuration (for convenience's sake, referred to herein as " configuration C " or " configuration 1 ") may include in temple region
Eyes side, such as slightly above right eye and on the right side of right eye or slightly above left eye and on the left of left eye) first electrode 10 and position
In the placement of the second electrode 13 of forehead (for example, the close nasion or higher than the nasion).
Another configuration (for convenience's sake, referred to herein as " configuration B " or " configuration 3 ") may include to be located close to tested
Person's temple region (for example, eyes side, such as slightly above right eye and on the right side of right eye or slightly above left eye and on the left of left eye
Subjects skin on electrode 10, and in the second electrode 12,306 of experimenter's cervical region, e.g., centered on center line and
Along hair line base portion be horizontally oriented and the spinal cord that partly overlaps).Fig. 1 C and Fig. 1 E illustrate that the electrode of configuration B is placed
Approximate region.The TES in the region stimulates can be caused to strengthen the mental status that is tranquil or loosening.
Electrode described above is placed and can also be used for causing phosphene in Figure 1A -1E, below that its is more particularly described below.
Carrying out non-invasive transcutaneous electrostimulation by using the device being described herein can be induced to phosphene.The all percutaneous electricity of first socket of the eye
Pole (very close to eyes) and for it arrangement be that (that is, second electrode can be placed on offside socket of the eye to the second secondary percutaneous electrode
On other positions of axle area, skull, cervical region, shoulder, leg or experimenter's body) transmission percutaneous current waveform, to cause light unreal
Depending on.In Fig. 1 D, experimenter 300 has the single mastoid electrode 300 and socket of the eye week electrode 302 behind ear 303, and this is
Typically configure with " energy " configuration identical for showing in figure ia, for arousing the energy response being described herein.In figure
In 1E, experimenter 300 has single neck electrodes 306 and two sockets of the eye week electrode 304,305, its can be it is equipotential or
Detached circuit, it can be independently triggered with for retinal location induces clearly phosphene；The configuration be with this
" calmness " configuration identical in content and Fig. 1 C described in text is typically configured.
In general, the peak value stimulus intensity of at least more than 3mA can be beneficial to by brain, nerve (for example, cranium god
Jing, vagus nerve, peripheral nerve) and/or spinal cord cause the transcutaneous electrostimulation of neuroregulation as target.In order to realize these
Peak strength and pain is not produced in experimenter, is stimulated or uncomfortable, it may be necessary to suitable electrode and TES waveforms.Favourable
Electrode can have pH damping characteristics, and can include and passed towards skin portion through electrode for equably (or relatively evenly)
Pass the part of electric current.
The TES waveforms being used together with any configuration in the configuration being described herein can be transmission (for example, percutaneous
Ground) to the pattern of the electric current in experimenter's tissue.Although there may be recognizing for each configuration (electrode position) and each target
Know these waveforms of state and the modification (optimization) of electric scheme, but in general, pattern can be in the same range of value, to carry
For the signal of high intensity, altofrequency, high duty ratio and charge unbalance (for example, direct current offset), the signal is applied in big
Steadily arouse response in most individualities, also result in the uncomfortable and/or pain of low-level (for example, minimum or nothing).
Herein, TES waveforms can be referred to as gathering waveform, because they generally include multiple (for example, 3 or more
It is multiple) component waveform, its have it is following in the predetermined value of each：Current amplitude (" intensity "), frequency, charge unbalance hundred
Point than (also referred herein as " DC skews "), dutycycle, Modulation and Amplitude Modulation (in some variations) and some deform in
Capacitive discharge.Each in these component waveforms also has the persistent period, and is linked in sequence together, with the phase of arousing
The cognitive effect of prestige.It is tiltedly to become that these form some component waveforms in the component waveform of set waveform, and wherein waveform is to work as ripple
When shape component the past value changes, waveform component value (frequency, intensity, charge unbalance percentage ratio and dutycycle) is reached
Tiltedly become.
Percutaneous and/or Jing craniums are transmitted the time-varying pattern of the electricity irritation adjusted with inducing neural and are referred to alternatively as transcutaneous electrostimulation ripple
Shape (" TES waveforms ").Stimulation protocol can limit the temporal mode of the electric current for being delivered to anode-cathode group, and can be including one
Individual or multiple waveform components, the waveform component is included but is not limited to：DC current, alternating current, pulse current, linear tiltedly change
Electric current, non-linear oblique time-dependent current, the oblique time-dependent current of index, current-modulation (for example, the amplitude modulation(PAM) in one or more frequencies,
Stimulate including explosion and sine wave modulation stimulate) and more complicated (including repetition, random, pseudorandom and chaotic pattern).
In operation, the equipment can be target area (for example, in brain, face nerve, vagus nerve, and/or other neuronal targets)
There is provided electric current flowing to adjust with the inducing neural when appropriate electrode configuration and stimulation protocol are passed.
In general, TES waveforms can be by persistent period, direction (and being one pole or two-phase), peak point current and frequency
To limit.Fig. 2A is according to one embodiment of present invention, it is schematically shown that TES waveforms.In certain embodiments, TES
Waveform also by percent duty cycle, direct current percentage ratio (also referred to as uneven electric charge percentage ratio), tiltedly become or other Modulation and Amplitude Modulations, one
Individual or multiple frequency components, the phase relation of biphase current, flat or structured noise, waveform (i.e. sawtooth waveforms, triangular wave, just
String ripple, square wave, index or other waveforms), capacitance compensation feature or be such as on November 26th, 2013 submit to it is entitled
“Wearable Transdermal Electrical Stimulation Devices and Methods of Using
The other parameters discussed in the U.S. Patent Application No. 14/091121 of Them " are limiting, and No. 14/091121 U.S. is special
Profit application entire contents are herein incorporated by reference.As used in this article, " percent duty cycle " also refers to cause
Non-zero (nominally or being non-zero) electric current carries out the period proportional of the waveform of transdermal transfer (referring to the equation of Fig. 2).Additionally, " straight
Stream percentage ratio " also refers to the non-zero (referring to the equation of Fig. 2A) of the wave period of positive traveling.
Induction is significantly, sane and/or reliably cognition effect generally needs the appropriate TES ripples limited by one group of parameter
Shape.Stimulation protocol (' TES waveforms ') can limit the temporal mode of the electric current for being delivered to anode-cathode group, and can be including one
Individual or multiple waveform components, the waveform air quantity is included but is not limited to：DC current, alternating current, pulse current, linear tiltedly change
Electric current, non-linear oblique time-dependent current, the oblique time-dependent current of index, current-modulation and it is more complicated (including repeating, random, pseudorandom and
Chaotic pattern).In operation, the equipment can target area (for example, in the brain, in cranial nerve) provide electric current flowing with
When appropriate electrode configuration and stimulation protocol are passed, inducing neural is adjusted.
In order to draw phosphene, it is possible to use big quick on the electric current between socket of the eye axial electrode and another electrode
Change.The amplitude of very first time of electric current change reciprocal and on electric current be reliably induce the factor of phosphene-for
It is bigger for phosphene induces then better for both.For example, at least change of 5mA of peak point current is in less than one second
For reliably inducing the effective TES wave characters of phosphene.In addition, apply waveform Modulation and Amplitude Modulation (" Modulation and Amplitude Modulation " or
" burst mode ") it is the Burst frequency or Modulation and Amplitude Modulation for working as (upper frequency carrier wave)<(especially less than 70Hz is simultaneously optional for 100Hz
Ground is in about 8Hz and about between 50Hz) when, trigger another kind of effective means of phosphene.
Fig. 2 B show peak point current (or voltage) value for inducing the TES waveforms of the example of phosphene.Peak value electricity
403 (it can be positive or negative in different modifications) of stream are passed to experimenter for a period of time, then quickly reduce by 400,
It is maintained at low value one second 401, then gradually ramps up to high intensity 402, this enables another phosphene in time point below
It is induced into.In variant of the invention, the quick big of short duration increase of current intensity also can effectively induce phosphene.Such as exist
Described herein, peak point current (or voltage) value can correspond to pulse ac electric current or another high frequency TES waveforms
Peak value.For most people, the maximally effective waveform for causing phosphene be in superciliary polarity from negative to positive
Reverse (or in this case, or charge unbalance biphasic waveform is basically negative reverse to being substantially just
).
Waveform parameter group can be according to quantity, the position of electrode, the size of electrode, the electricity of required cognitive effect and electrode
The anode-cathode of the shape of pole, the combination of electrode and electrode is to (that is, whether thermocouple is combined into anode or cathode to one group electrode；Separately
Whether multiple autonomous channels of external stimuluss occur via the current source for driving independent positive level-cathode sets) being selected.Change
Becoming any feature in above-mentioned list may need to be adjusted by changing one or more parameters to obtain desired cognitive effect
Section TES waveforms.For example, for high frequency overlap biphasic impulse, relative to galvanic stimulation, current intensity can the nothing in oblique ascension very fast
It is uncomfortable.The advantage of this feature is being capable of the favourable cognitive effect of rapid induction and without pain, the side effect that stimulates or divert one's attention.
As mentioned above, waveform sets are arranged to arouse specific neutral response or specific knowledge effect waveform
Combination.Some waveforms (waveform sets) are configured to induce quietism state, and can be used for such as in Fig. 1 C and
The special electrodes configuration illustrated in Fig. 1 E.Some waveforms are configured to the mental status that induction ratio is more energetic or concentrates, and
These waveforms can be used for such as the electrode configuration shown in Figure 1A and Figure 1B and Fig. 1 D.Waveform sets may also comprise " embedding
Set " waveform, it may include shorter waveform elements through at least two time scales, to obtain the cognitive effect of extension.Bag
The waveform sets for including the waveform of nesting can be used for inducing sustained, stronger or offer correlation but subjective different experience
(for example, a TES stimulus waveforms can cause the power of increase to cognitive effect, and the TES stimulus waveforms of the second correlation cause increase
Clearheaded and concentration).Device (including applicator and/or the teleprocessing unit with applicator pairing) can include that these are various
Sets of waveforms, and can be selected by experimenter (in some cases, changed by experimenter).
As mentioned above, be adapted for the nerve stimulator of method and apparatus described herein may include for
The Hardware ＆ software system of TES, such as：With the battery or power supply of main power source security isolation；It is every for triggering TES events and control
The control hardware of the waveform of the stimulation of individual electrode, persistent period, intensity and other specification, firmware and/or software；It is used for carrying
It is electrically coupled to one or more pairs of electrodes of the gel, saline or another kind of material of scalp.For the hardware of TES, firmware and software
Extra or less part can be included.Can include various parts for the hardware of TES, firmware and software.
The TES methods and various configurations being described herein can be used for being capable of appointing for the appropriate TES waveforms of transdermal transfer
What TES system.In general, TES system can use the electrode of adhesion and/or by wearable device (that is, cap, headband, item
Chain, spectacle-frame can make other constituent elements that electrode contacts with the physical skin of experimenter) electricity that is secured in place
Pole.In general, the power supply of TES controllers, current controller and other electronic circuits (for example, safety circuit and alternatively, nothing
Line communication chipset) can be in hand-held, desk-top or other hand-held control device systems；It is directly connected to one or two electrode
Or be wired to electrode and otherwise another wear structure (for example, head (or can be placed on by user's wearing
Band or cuff；Pocket；Necklace, earrings or frame) in) wearable part；Or be entirely it is disposable and with the system
One or more percutaneous electrodes it is integrated.
For example, embodiments of the invention are included with regard to using electrode by by appropriate TES according to configuration A and/or configuration B
The method that waveform induces above-mentioned cognitive effect from transcutaneous electrostimulation systems communicate to experimenter.Generally, embodiments of the invention
Also include system, thus except storage one group can by the readable storage medium of the non-transient computer of the instruction of computing device it
Outer TES devices include power supply (such as battery), current control and safety circuit, processor (i.e. microprocessor, microcontroller or similar
Thing), conductive connector and/or be connected to the cable of anode and negative electrode, and alternatively include wireless communication module, wherein institute
State instruction when being executed by a processor, cause TES waveforms in anode (or a group etc. electric anode) and negative electrode (or electricity the moon such as one group
Pole) between transdermal transfer.
Fig. 4 each embodiment of the invention, the system for schematically showing the user's control for nerve stimulation.One
In a little embodiments, the system can include Neuroregulators and application on the user computing device.User's computing device can be with
Select from the list for including, without being limited to the following：The operation Android of such as iPhone or Samsung Galaxy or
The panel computer of the smart mobile phone of iOS operating systems, such as iPad, the PC including kneetop computer and desktop computer,
Wearable computing devices (for example, Google glasses or intelligent watch), remote controllers or any other applicable calculating set
It is standby.User's computing device may also include biosensor (or can match with biosensor, with from the sensor receiving data)
(for example, the sensor of heart beating, breathing, direction of gaze, platycoria, cerebral activity (that is, by EEG), circulation molecule etc.).
In some embodiments, Neuroregulators can include the controller of at least one pair of percutaneous electrode and Neuroregulators.In some realities
In applying example, bonding or wearable nerve stimulator can include component：Battery, memorizer, microprocessor, current control electricity
Road, electric fuse and other safety circuits, wireless antenna and chipset and waveform generator.User's computing device can be with
Including component：Wireless antenna and chipset, graphic user interface, for provide the feedback with regard to TES sessions one or many
Individual display element, one or more user's control element, memorizer and microprocessors.Application program can be downloaded to by user
User's computing device, to run and control the nerve stimulator for TES nerve stimulation sessions.In certain embodiments, user
Computing device can be arranged to control the remote controllers of nerve stimulator；The application program can be stored in remotely control
On device.One of this area those having ordinary skill in the art will be appreciated that nerve stimulator can include various parts, user's computing device
Various computing devices can be included, and application program can be stored in remote server, Data Holding Equipment, and/or user
In computing device.
Nerve stimulator is configured to wireless communication protocol and user's computing device two-way communication.The system can
It is configured to wirelessly pass on various forms of data, including but not limited to trigger, control signal, safety alarm signal, thorn
Swash timing, stimulus duration, stimulus intensity, other aspect, electrode quality, electrode impedance and battery levels of stimulation protocol.
Can be communicated with equipment and controller using methods known in the art, methods described include but is not limited to RF, WIFI,
WiMax, bluetooth, BLE, UHF, NHF, GSM, CDMA, LAN, WAN or other wireless protocols.By the pulse of such as remote controller
Infrared ray is extra wireless forms of communication.Near-field communication (NFC) is for entering with neural modulation system or neuroregulation disk
Another kind of useful technology of row communication.One of ordinary skill in the art will be understood that exist and can be used for embodiments of the invention
Various wireless communication agreement, and embodiments of the invention are envisioned for being used together with any wireless communication protocol.
As mentioned, waveform sets can include nested waveform and/or including it is multiple (for example, 3 or more, 4
It is individual or more, 5 or more, 6 or more, 7 or more etc.) component waveform of tandem compound, to obtain the phase
The cognitive effect of prestige.Favourable cognitive effect Jing is often with several seconds to a few minutes even to the time lengthening of a few houres.For example, if
They extend a period of time (for example, a few minutes are to dozens of minutes or longer), tranquility or the energy for perceiving or power
Increase it is best for user would is that.In order to realize the cognitive effect for extending in time, waveform can be by including repetition
The shorter element of element is constituted.
Neuroregulators can include the shorter waveform of the cognitive effect for realizing extending through at least two time scales
Element.Neuroregulators can include carrying out at least one pair of percutaneous electrode of telecommunication with controller.In general, user can be with
The all or part of neuroregulation equipment is worn on his/her head so that each percutaneous electrode may be arranged at the head of user
In portion.In general, the quantity of electrode, combination and be distributed and the position of percutaneous electrode, size and dimension can affect by with
The neuroregulation that family receives.In general, the percutaneous electrode dressed by user can induce recognizing for type as described above
Main effect.
Neuroregulators (nerve stimulator) can include that waveform sets can be received from user equipment that (or description is selected
Waveform sets parameter) processor, remote server or other storage facilities.In general, processor (nerve stimulation
The controller of device/controller in nerve stimulator) waveform sets can be caused to be delivered to percutaneous electrode pair, and control by
The nested waveform that percutaneous electrode is used.In general, nerve stimulator can include the induction battery or another species of outside
The power supply of type.
It is being described herein, be included on Neuroregulators device run or it is using Neuroregulators plant running
The device of control logic, may be configured to receive, store, transmit and analyze in some cases the user with the device
Interactive data.For example, the device can record or notice all or part of of the user mutual of the device, for example, include：
Set waveform, one or more skins/contact reading asked by device and/or played are (for example, by device continuously or the cycle
The Skin Resistance history of ground sampling), for adding (add-in) effect (for example, phosphene, prolongation etc.) in any effect
Request/order, the time for playing set waveform, it is early terminate, and/or user feedback (ranking, grade, labelling etc.), and/or with regard to
The information (for example, age, sex, position etc.) of user.
In some variations, (for example, the information can be transferred to the remote server for storing and/or analyzing
" cloud ").For example, the information can be used for improve consumption experience (for example, based on including extension information customer interaction information and repair
The set waveform for changing/setting up).In some variations, the information can be used to determine whether client needs one or more new parts
(for example, for the electrode of Neuroregulators), and remote server can contact user, be to order or order again extra
Part (for example, the electrode of particular module) is offered (including discount offers are adopted).
In some variations, all tracking informations as described above may be used to provide customer support.For example, based on user
Use, can to user send with regard to device operation message and/or suggestion；If user terminates ahead of time all the time transmission set
Waveform, or if user is all the time by intensity decreases to less than threshold level or any other tolerance or the combination measured, clothes
Business device can initiate the communication (for example, calling, text, Email etc.) with user, to provide suggestion/guidance.In some changes
In type, user can cancel this, and/or cancel some or all in collection data described above.
In various embodiments, user equipment can allow user's control Neuroregulators, such as provide dynamic for controller
The nested waveform of power, operation, and/or control transcutaneous electrostimulation session.User equipment can include transporting on the user computing device
Capable application software.Operate using the nerve stimulator that can be dressed by user.Pass through using user's computing device can be controlled
The communication of wireless two-way is carried out with nerve stimulator to nerve stimulator transmission instruction and from nerve stimulator reception signal.
In various embodiments, user equipment can be used by user, cognitive to run and/or control nerve stimulator modification
State.In certain embodiments, waveform sets can be downloaded and be saved in the application program in user's computing device.User
Equipment can be presented multiple waveform sets to the user with user's computing device in the user interface.User equipment can be allowed
User selects waveform sets from multiple waveform sets.User equipment can be wirelessly transmitted to neural tune the parameter of waveform sets
The controller of section device, such as by bluetooth.Radio communication may be configured to via the Internet or other LANs or wide area
Net is being transmitted.Any content of radio communication can be used, the information listd under being related to including but not limited to：With regard to
The diagnosis of apparatus function, battery electric quantity, TES sessions, user data, geographic position data, from being included in TES devices
The original and/or treated data of sensor (for example, accelerometer, EEG sensors, EMG sensors etc.) or other letters
Breath.
In general, the present invention can include that storage can be referred to by one of the computing device in user's computing device group
The readable storage medium of non-transient computer of order, one group of instruction makes when being executed by a processor processor allow user to select
For controlling one or more (or one group) control parameters of nerve stimulator.The group instruction can be included validating that and nerve stimulation
The communication of device link, and one group of waveform sets for being configured to change user cognition state are presented to user.The group instruction
Can be included on the screen being connected with processor and show one group of waveform sets for being configured to change user cognition state.One
In a little embodiments, the group instruction can include presenting the list of the controlling value being pre-selected and/or menu (for example, with regard to electric current
Amplitude, power frequency, pulse width, pulse duration, pulse frequency, impulse waveform, burst duration, train of pulse frequency
Among rate, turn-off time, burst waveforms, positive dutycycle, negative duty, Modulation and Amplitude Modulation parameter and on/off etc. one
It is individual or multiple).The group instruction can allow user that a waveform sets are selected from this group of waveform sets.One group of instruction can
With the transmission for allowing controlling value or indexing nerve stimulator, with nerve stimulator from possible predetermined waveform collection
These controlling values are selected in the list of conjunction.Group instruction can be included to be applied to the head of user by nerve stimulator and handle
Waveform sets parameter is transferred to nerve stimulator.
In certain embodiments, user equipment can allow user's registration account and the login account as shown in fig. 5
Family.As shown in figure 5b, user equipment can allow user as user name and to select using his/her E-mail address
Select password.User equipment can allow user to store relevant user information in the account of user.
In certain embodiments, user equipment can allow user with nerve stimulator bidirectionally (for example, via bluetooth)
Communicated.As shown in fig. 6, user equipment can allow user to match user's computing device and nerve stimulator.
User equipment can within the specific limits search nerve stimulator, and user is notified after nerve stimulator is found, such as Fig. 6 B
It is shown.After user equipment located nerve stimulator, user equipment can be attempted being calculated in nerve stimulator and user and set
Connection is set up between standby.Fig. 6 C show that when setting up connection user equipment can point out user.Fig. 6 D show and treat as
When work(sets up connection, user equipment can notify user.User equipment can allow user to be named nerve stimulator, or
Person skips over name and continues directly to start and control nerve stimulation session.
In certain embodiments, user equipment also allows for user's confirmation and applies electrode.User equipment can be configured to
User's computing device is allowed to detect whether to apply electrode.In certain embodiments, nerve stimulator is configured with finger
Show whether apply electrode and the element using electrode in which kind of configuration.For example, in one embodiment, ought not have
Can be that nerve stimulator is configured with capacitor in the case of zero using the electric current of capacitor during electrode, and
Whether " calmness " whether apply the electric current of capacitor after electrode can be in shown in Fig. 1 C with indicating electrode configures, locates
" energy " configuration shown in Figure 1B is configured or whether is in shown in figure ia " energy ".In some other enforcements
In example, in some other elements such as, the electrical quantity of electric current, inductance or resistance can be used to detecting whether applying electrode with
And the configuration of electrode.
Fig. 7 according to one embodiment of present invention, illustrates the user interface of the subset that each cognitive effect is presented.At each
In embodiment, the waveform sets for changing cognitive state can be downloaded to and be saved in the application journey in user's computing device
In the storehouse (that is, data base) of sequence.Waveform sets may be logically divided into different subsets, for example, " calmness " or " energy ".In tranquil " son
Waveform sets in collection " are designed to be had in tranquil effect on user.On the other hand, the waveform collection in " energy " subset
Conjunction is designed to make user feel more energetic, impassioned and concentrate.
In certain embodiments, user equipment can allow user to select in expectation cognitive state (for example, such as in Fig. 7
In the tranquil or energy that illustrates) waveform sets subset.In certain embodiments, the electrode of application is detected in user equipment
With postponing, user directly can be taken to user equipment the use of the multiple waveform sets being presented in the corresponding subset of cognitive effect
Family interface.For example, detect that the electrode of application is that " calmness " as shown in fig. 1 c is matched somebody with somebody and postponed in user equipment, user equipment can
So that user directly to be taken to the user interface of the multiple waveform sets being presented in the subset of " calmness " effect.Therefore, Yong Hushe
The step of for the subset that can skip over the cognitive effect of user's selection.
In certain embodiments, user equipment can help user the application of electrode of nerve stimulator in user's body
Tram.User equipment can show film, to be given about how application of electrode is right to realize in different configurations
The guidance of the cognitive effect answered.For example, as shown in FIG. 7, user equipment can allow user by clicking on bottom of screen
The small icon with alphabetical " i ", watch about how the guidance for correctly applying electrode.
In certain embodiments, user equipment can be configured to allow user to help using the camera of user equipment god
The electrode of Jing stimulators is correctly positioned.For example, user equipment can allow user by being pressed against the little shooting of bottom of screen
Machine icon watching " mirror " (forward direction camera), as shown in Figure 7.After user's pressing camera icon, user equipment can be with
The camera function of user equipment is opened, to help user that electrode is correctly placed at desired position.In certain embodiments, use
Family equipment can allow user by pressing camera button to catch video, to aid in user to arrange electrode.For example, put in user
While putting electrode, user equipment can show real-time video or camera figure on screen with " mirror mode " (forward mode)
Piece.Additionally, user equipment can be the visual guide of the configuration with regard to showing on screen together with real-time video or camera picture
It is concomitantly introduced into.In another embodiment, in " augmented reality " framework, computer vision algorithms make user on the face or head
Upper use reference mark so that electrode configuration is piled up in video or camera picture higher slice, it is fixed with regard to electrode to provide the user
The feedback of position.User equipment can be static from forward direction cameras capture or image of video recording is used for automatic or artificial analysis,
To provide the user feedback with regard to equipment positioning.
The group instruction being stored in non-transient storage medium may also comprise for by the equipment (for example, main electrode area
Both domain and auxiliary electrode region) instruction of tram that is applied on body and/or guidance.For example, in user's computing device
Processor on executable one group of instruction may include to show one or more figures that this one or more figures are indicated nerve
The position on user that the first electrode and second electrode of stimulation apparatus is arranged in.The group instruction can include playing film,
The film is illustrated how using nerve stimulator electrode.The group instruction can also include showing by using the camera of user equipment
Show mirror, to help being properly positioned for the electrode to nerve stimulator.
Fig. 8 A and Fig. 8 B respectively some embodiments of the invention and illustrate and be presented on respectively " calmness " and " energy "
The example of the user interface of the user equipment of the multiple waveform sets in subset.User equipment can be presented in storehouse to user
Multiple waveform sets.User equipment can allow user that specific waveform sets are selected from multiple waveform sets.Waveform sets
Selection instruction user want to run special waveform sets in transcutaneous electrostimulation ession for telecommunication.For example, user equipment can be in
The list of each waveform sets for showing in Fig. 8 A and Fig. 8 B now.User equipment can be presented continuing for waveform sets to user
Time, average rank and user gradation.User can select waveform collection by pressing " being vibrated (Play Vibe) "
Close, wherein " vibration (Vibe) " is the short notes of " waveform sets ".
Fig. 8 C illustrate another example of user interface according to another embodiment.User equipment can be in user interface
It is middle that " playlist (playlist) " is presented to user.Selection instruction user from the waveform sets of playlist is wanted
The specific waveform sets are run in transcutaneous electrostimulation ession for telecommunication.
User equipment can in a variety of manners (including but not limited to list, form, image or other various forms) to
Family is presented on the multiple waveform sets in storehouse.In certain embodiments, user equipment can also provide personalized waveform sets.Example
Such as, user equipment can be by providing diagnosis to a user's query basket.User equipment can be according to answering from user
Case is recommending waveform sets.User equipment can create user's overview using the answer from diagnosis problem.Recommend waveform
Set can be personalized waveform sets select and/or design by analysis user's overview.
The waveform sets parameter or index that user equipment can select user is wirelessly transmitted to nerve stimulator.In user
Equipment allows user to select after specific waveform sets, and user equipment can communicate with nerve stimulator, and indicate nerve
Stimulator applies the waveform sets that the spy of user's selection selects.In certain embodiments, user equipment can be specific waveforms set
Control parameter transmit to nerve stimulator.In some other embodiment, user equipment can be the rope of specific waveforms set
Draw and transmit to nerve stimulator.
In certain embodiments, user equipment can be wirelessly and periodically during the stimulation cycle waveform sets
Parameter is in the way of chunk from user device transmissions to nerve stimulator.When user equipment can press first during the stimulation cycle
Between be spaced waveform sets parameter transmitted to nerve stimulator.For example, very first time interval can be 100 milliseconds, 200 milliseconds,
300 milliseconds, 400 milliseconds, 500 milliseconds, 600 milliseconds, 700 milliseconds or 800 milliseconds or any value between them.It is also possible to
It can be the value outside range above.Alternatively, very first time interval can be very short so that waveform sets parameter for example passes through
Using the interval less than 100 milliseconds (that is, less than 50 milliseconds；Less than 25 milliseconds；Less than 10 milliseconds；Less than 5 milliseconds；Or less than 1 milli
Second) and in real time or near real-time be transmitted.Nerve stimulator may be configured to transmit confirmation letter in the second time interval
Number (for example, heart beating).Second interval can be spaced less than the very first time.In certain embodiments, if user equipment does not connect
Confirmation signal is received, user equipment can stop the transmission to waveform sets parameter with instruction user computing device.
Before operation user selects the specific waveforms set for nerve stimulation session, user equipment may remind the user that
Correct union joint machine (that is, electrode assembly) is checked whether, as shown in Figure 9 A.In some variations, can be with automatic detection electrode class
Type, and be only suitable for the waveform of the electrode group and cognitive effect and be displayed for user's selection.As discussed above, electricity
The different configurations of pole can cause different cognitive effects.For user it is important that electrode assemblie is used for electricity with correct configuration
Pole, cosily to receive significant cognition effect.User equipment also can hold the record user use nerve stimulator history,
Configuration that it includes applied electrode, selected waveform sets, user have played the total time of specific waveforms set, user
Last time of waveform sets, all users are played (or according to demographic, psychographic or geography point
The subset of the selected user of class) global average rank；And the user gradation of waveform sets etc..Fig. 9 B illustrate presentation user
Using the example of the user interface of the history of nerve stimulator.As shown in figures 9 b and 9, user equipment can be presented to number of users
According to analysis.For example, analysis can include the history of the Consumer's Experience for using specific waveforms set (including the time using waveform
(that is, timeline)), and effect and/or comfort level grade.Analysis can be indicated via the following control that will be discussed
The TES that user has selected stimulates the perceptive intensity of ession for telecommunication.
Figure 10 A, Figure 10 B and Figure 10 C some enforcements of the invention exemplify permission user and are applying the waveform sets phase
Between control applied waveform sets user interface example.In various embodiments, user equipment can allow user to exist
Applied waveform sets are controlled during applying waveform sets using user equipment.For example, when user is by clicking on icon, by thing
When reason button, switch etc. carry out activated user interface, the transmission of waveform sets can start, suspend, stopping or being modulated (example
Such as, the parameter of TES waveforms is changed).
In various embodiments, storing one group can be by the non-transient meter of the instruction of the computing device of user's computing device
The readable storage medium of calculation machine cause user interface for start the waveform sets that will show on the screen of computing device, and
Startup is connected to the control of processor.The group instruction can include these control parameters for the waveform sets for allowing modification applied
In one or more.User can adjust control to change applied waveform sets during waveform sets are applied.The group
Instruction can include the perceptive intensity for allowing user that applied waveform sets are adjusted during waveform sets are applied.
Figure 10 A show and calculated in the user for controlling and/or changing waveform sets in transcutaneous electrostimulation ession for telecommunication
One example of the user interface on equipment.In certain embodiments, user interface can include at least one interactive component, institute
Interactive component is stated at least one element in modulation waveform set.In certain embodiments, user can pierce in percutaneous electricity
Before sharp session and/or period modulation waveform set.In certain embodiments, user can modulate TES waveform sets intensity,
Frequency, amplitude, tiltedly persistent period, change, pulse length, peak point current, percent duty cycle, Modulation and Amplitude Modulation parameter or electric charge injustice
Weighing apparatus percentage ratio.In certain embodiments, user equipment can allow users with user equipment and lead to during waveform sets are applied
Cross overall cognitive effect of the perceptive intensity of the applied waveform sets of adjustment to adjust in nerve stimulation ession for telecommunication.Perceive strong
Degree can be used to represent the overall cognitive effect that user perceives from the waveform sets for being applied.Perceptive intensity may arise from including
Electric current, frequency, dutycycle, Modulation and Amplitude Modulation parameter (amplitude modified frequency, amplitude modulation waveforms, Modulation and Amplitude Modulation dutycycle etc.), with
And the combination of the waveform parameter of charge unbalance percentage ratio.For example, perceptive intensity can be calculated by following equalities：
Perceptive intensity=electric current x (11000/ frequency) x (0.5+ charge unbalances percentage ratio/200) x (dutycycle/100)
As shown in Figure 10 A, user equipment can pass through to include allowing what is will be applied in certain embodiments
The control of the percentage ratio (0%-100%) of perceptive intensity modulates applied waveform sets allowing user.User equipment can be with
User is allowed to control Neuroregulators to control overall cognitive effect by adjusting perceptive intensity.Storing can be calculated by user
The readable storage medium of non-transient computer of one group of instruction of the computing device of equipment can cause user interface to allow user
Adjust the perceptive intensity of the waveform sets applied during waveform sets are applied.The group instruction can also allow for experimenter and beat
Opening/closing equipment.
User equipment can allow user by icon 101 of the pressing with "+" symbol gradually to increase perceptive intensity.Can
Gradually to increase perceptive intensity with little step, to guarantee the safety of user and comfortable.On the other hand, for enhanced perceptive intensity
Time delay can not be too big.Otherwise, user can pass through several increments in the case of the change for not feeling the intensity on skin
To strengthen intensity, therefore intensity too fast will be increased by increase user and be not conducive to feeding back perceptive intensity via dermal sensation
Change probability and cause safety problem.For example, perception can be increased from 0.01 milliampere per second to 1 milliampere per second
Intensity.It can be the value outside range above to be also possible to.For example, by can by user press button represent and its
Induction of phosphene 105 or the of short duration change in the intensity of electricity irritation is caused to strengthen the specific of the cognitive effect 106 of induction
" addition " effect can trigger the change more than 1 milliampere/second in intensity.
User equipment can allow user quickly to reduce perceptive intensity or terminate TES nerve stimulation sessions.When user may
When feeling uncomfortable or pain, or when the electronic circuit of TES nerve stimulators has some problems, user equipment can be permitted
By icon 102 of the pressing with "-" symbol, to reduce perceptive intensity, (for example, repeated presses icon 102 is to drop in a large number at family allowable
Low perceptive intensity) or (there are pros by pressing " time-out " button (there is the icon of two parallel lines) or " stopping " button
The icon of shape) terminating waveform sets.In certain embodiments, user equipment can allow user reduce immediately perceptive intensity or
Terminate TES nerve stimulation sessions.In certain embodiments, user equipment can allow user relatively fast with cycle regular hour
Perceptive intensity is reduced fastly or terminates TES nerve stimulation sessions so that user will not feel because of perceptive intensity is reduced suddenly
Pain (that is, the intensity of stimulation can be by five seconds come gradually oblique deascension).For example, can be from 0.5 milliampere per second to per second 10 millis
Perceptive intensity is reduced between peace.It can be the value outside range above to be also possible to.
Figure 10 C show the use in transcutaneous electrostimulation ession for telecommunication in the user's computing device for being used to control waveform sets
Another embodiment at family interface.In certain embodiments, user can with the intensity of modulation waveform set, frequency, amplitude, continue
Time, tiltedly change, pulse, peak point current, percent duty cycle, Modulation and Amplitude Modulation parameter or charge unbalance percentage ratio.In some enforcements
In example, as shown in Figure 10 C, interactive component can include virtual rotating disk, slider bar, button, stick, drop-down row
The interactive component of table, data input field, and/or any other type.For example, can be by the way that virtual slider be slid onto or is slided
To increase or decrease frequency and electric current.In some variations, user interface can include a control, its change immediately two or
More parameters (for example, frequency and peak strength, it can together increase/reduce, or in any other relation, for example,
Increase frequency and reduce intensity simultaneously, vice versa).
In certain embodiments, user interface can include " restarting " slider bar, intervalometer, connection status hurdle, with
And other designators (for example, the button of broadcasting/time-out group).In certain embodiments, " restart " slip hurdle and can be used for weight
Newly start transcutaneous electrostimulation session.In certain embodiments, user interface can indicate to the user that the state of connected equipment.
For example, connection status hurdle can indicate that controller, paired percutaneous electrode or another equipment are connected.In another example
In, connection status hurdle can indicate the battery charging state of controller.In certain embodiments, connection can be hardwire connection
Or wireless connection.In certain embodiments, software is configurable to continuously check and sets in neuroregulation equipment and controller, calculating
Wireless connection conditions between standby or any other type equipment.
Any modification in the modification being described herein can allow user and extend ongoing with the time of additional quantity
(or just terminated) set waveform.For example, control (for example, button, slider bar etc.) can be presented on a user interface, or
During the terminal of the passing time that can work as close set waveform (or after set waveform one is complete then immediately) occur.Then,
The button or slider bar can be selectable, (be added with allowing to add the extra time on the afoot set waveform of user
Plus extra set waveform duration).Component waveform before the waveform of addition can repeat (for example, forms last x minutes
Set waveform component waveform, wherein, last x minutes refer to seek the time quantum by extending addition, and for example, x can be with
Between 30 seconds to 1 hour (for example, 30 seconds, 1 minute, 2 minutes, 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9
Minute, 10 minutes, 15 minutes, 20 minutes etc.)) in one or more.The device can allow the unrestricted prolongation of time,
Or the quantity for extending can be limited in some quantity (for example, 1,2,3,4,5,6,7,8,9,10 etc.).This is properly termed as " shaking
It is dynamic " extend or play prolongation (or set waveform extends).
As mentioned, in some variations, prompting and/or control (example near the terminal of waveform sets passing time
Such as, button etc.) can become visual and/or available.User can also be prompted to extend and/or be asked whether they are ready
Extending sessions.For example, when set waveform of the operation with 10 minute persistent period, when still suffering from (for example, 5 points of remaining time
Clock, 4 minutes, 3 minutes, 2 minutes, 1.5 minutes, 60 seconds, 30 seconds, 15 seconds etc.) when, device (for example, user interface) can be inquired
User they whether want increase session time (for example, 5 minutes).If they select/agree to extend, extraneous component ripple
Shape is added to the end of waveform and transmits without the need for stopping.This is when user has selected appropriate intensity and got used to dermal sensation
Can be highly useful so that they can feel stronger effect (for example, the effect of tranquil or energy), and it will pass through
The waveform of prolongation and fully experienced.
With reference to Figure 10 A, Figure 10 B and Figure 10 C, user equipment can allow the triggering of user's control nerve stimulator to predefine
Signal, the predetermined signal include but is not limited to phosphene, booster (that is, one or more set waveform parameters
Of short duration (be less than 20 seconds, be alternatively less than 10 seconds)) (what is generally stimulated being instantly increased and then instantaneous reducing or instantaneous for modulation
Reduce and then be instantly increased)) or any other signal.In certain embodiments, user can be in the transcutaneous electrostimulation session phase
Between introduce phosphene scheme.As shown in Figure 10 A, phosphene scheme or tiltedly change train of pulse can select empty by user
Intend button (that is, the button in the user interface of user's computing device) to initiate.When user can select can it is confined such as
When phosphene scheme or the tiltedly waveform modulator of change train of pulse, user interface can limit time point in TES ession for telecommunication.Pass through
Limit time point when manipulator can be triggered, system can only allow user modulator signal it is suitably comfortable and/or
Modulator signal is triggered when effectively.In certain embodiments, user equipment can include instructing the instruction for placing electrode, for
It is reliably produce phosphene.User equipment also allows for user's triggering booster.Booster can allow user to pass through instantaneously to subtract
The applied waveform characteristics of few then increase or the waveform characteristics by being instantly increased and then reduction is applied, and there is enhancing
Experience.In various embodiments, user equipment can allow user to trigger any predetermined signal.Storing can be by
The readable storage medium of non-transient computer of one group of instruction that reason device is performed can cause processor to refer to when by computing device
Show that nerve stimulator triggers predetermined signal, the predetermined signal include but is not limited to phosphene, booster or
Any other signal.
Pulse train, a kind of amplitude-modulated form, wherein make TES vibrate altofrequency (>750Hz) train of pulse is utilized
There is the stimulation for suspending being transmitted in centre, pulse train is that (that is, the cycle is contrary between train of pulse in the frequency of train of pulse
Things) less than during 100Hz (about 8Hz can be selected in and about between 70Hz) for inducing effective waveform of phosphene.
In certain embodiments, user equipment can on a user device show that the perception of the waveform sets that will be transmitted is strong
The expression of degree.This waveform sets that can be displayed next to or adjust with user in the perceptive intensity of the waveform sets of user's adjustment
Perceptive intensity superposition ground show, it can be by the actually applied perceptive intensity of nerve stimulator.In certain embodiments, will
The display of operation is shown as the annular as shown in in Figure 10 A and Figure 10 B (and and in figure 10d) and shows.
In general, user equipment can be shown the expression of the perceptive intensity of waveform sets to be delivered so that used
Family can be the estimation both of which visualization of the progress by set waveform and perceptive intensity.For example, user equipment can be more
The transient peak perceptive intensity of individual time interval display waveform set.As discussed above, when waveform sets put on user,
User equipment can allow user to strengthen button 101 or reduction button 102 to increase or decrease the sense of waveform sets by pressing
Know intensity.These user controls (button, rotating disk, slider bar, knob etc.) can be virtual (for example, on the touchscreen), or
Person they can be solid state on a user device control.Control can be pre-set in intermediate value (for example, by collecting
Close wave setting maximum perceptive intensity or peak value perceptive intensity 50%), the intermediate value can be can raise or can under
Adjust (for example, up to by set wave setting peak value perceptive intensity 100% or down to 0%, or close).Alternatively,
Control can be based on before the selected set waveform for using, other similar set waveforms or other with regard to user
Information (sex, age, skin quality, risk partiality etc.), and it is pre-set in the personalized value for user.Control can
To be indicated as percentage ratio or be not indicated.For example, user can select perceptive intensity by the control from user equipment
Percentage ratio adjusting the perceptive intensity of the waveform sets applied by nerve stimulator.User equipment can pass through will
The perceptive intensity of the waveform sets being passed expression come show user adjust perceptive intensity.For example, user equipment can be
Each time interval by the expression of perceptive intensity to be delivered by showing in different colors the perceptive intensity that user adjusts.Figure
10B illustrates that the operation when TES nerve stimulations session develops is covered and shows.In some other embodiments, operation is covered and shown
Can show including waterfall.Operation shows that the covering that can include chart, list, image, form or any other form shows
Show.User equipment can allow user's adjustment perceptive intensity and record the perceptive intensity of user's adjustment, and this can allow user
Or automatic system creates personalized waveform sets to realize personalized cognition effect.
Figure 10 D and Figure 10 E also show the example of display, wherein display set waveform (dotted line is shown as in figure 10d,
And be dotted line in Figure 10 E) maximum (or target) perceptive intensity, and show in Figure 10 D-10E and be shown as solid
, perceptive intensity after the adjustment of thicker line, it overlaps expression maximum/peak value perceptive intensity on dotted line.In the embodiment
In, perceptive intensity is calculated as the combination of the value of waveform parameter, it includes that frequency, current amplitude (are referred to as intensity, itself and perception
Intensity, distinguishes, can with but need not include one or more other waveform parameters), charge unbalance percentage ratio, Modulation and Amplitude Modulation parameter,
And dutycycle etc..Figure 10 D the figure for the maximum perceptive intensity of complete waveform sets being shown as to radial/ring-type,
And by arrow (it can be either any other symbol such as the point in Figure 10 A-10B --- or in perceptive intensity
Indicated by the embodiment of color or filling position in expression) indicate transmission waveform in user electric current place.In Figure 10 E
In, the perceptive intensity of maximum perceptive intensity and user's adjustment with regard to gathering waveform is shown as linear arrangement.In some variations,
This can be shown as line chart rather than the bar chart shown in Figure 10 D and Figure 10 E.Other arrangements are possible.Figure 10 F-10G with
And Figure 10 H-10I illustrate two kinds of set waveform (energy in Figure 10 F-10G and the calmness in Figure 10 H-10I)
Maximum or peak value perceptive intensity two other example.Although showing whole peak for the persistent period for gathering waveform
Value/maximum perceptive intensity is particularly helpful, but in some variations, it may be desirable to less window is only shown,
It can be updated to moving window and/or waterfall type shows (not shown).These displays can also show other features, including
User selects the control or phosphene 105 of such as booster 106 (for example, tiltedly becoming train of pulse) to trigger time of these events.
As shown in Figure 10 A and Figure 10 B, shown the display of the time that can also include keeping and/or running the time of waveform always.
In certain embodiments, user equipment can allow user provide with regard to waveform sets grade/labelling/ranking/
Marking/feedback.For example, Figure 11 A illustrate the user interface for allowing user's selection grade and sharing waveform sets.In some enforcements
In example, user equipment can also create community, wherein, user's group can share waveform sets, and from other users ranking is observed, and
And pass on their experience.For example, Figure 11 B illustrate the user interface for allowing user to submit response to.Figure 11 C illustrate user interface
Another example, it allows user to share his/her experience with friend, and including self-produced, (for example, personalization sets for the experience
It is meter or adaptation) waveform sets.Figure 11 D illustrate another example of user interface, its allow user for example via
Facebook, Google+, Twitter, Email or text and share his/her experience with friend.In some enforcements
Example in, user equipment allow user contact supports, Report a Problem, obtain with regard to nerve stimulation knowledge and access quickly open
Begin to instruct, as shown in Figure 11 B, Figure 11 C and 11D.
As used in this article, when " user equipment " (or user's computing device) is carrying out function or operation, should
It is understood by, can realizes configuring by software (for example, applying), hardware, firmware or some of which combination and control to use
The operation of family equipment.
In certain embodiments, user equipment can be provided a user with for buying, peddling, rent, borrow or in addition
Obtain set waveform or cause set waveform can (rent, lend) for sale market.User equipment can also be carried to user
The market that more multi-electrode matching component is bought at family allowable by user equipment is allowed for, as shown in Figure 11 A.In some embodiments
In, user equipment can be by the use of user monitoring electrode, as shown in Figure 11 E.User equipment can keep user to buy
Electrode quantity and amount record, and keep track electrode use.When user runs TES nerve stimulation sessions, use
Family equipment can detect the type of the electrode that user is applying, and remaining electrode is updated after nerve stimulation session
Quantity.In certain embodiments, user equipment can estimate electrode demand and automatic conveying is to user.In some embodiments
In, user equipment can allow user select order service, its will electrode counts be less than user's specified level when automatic conveying
Electrode.For example, Figure 11 F are illustrated that the user interface of the order service for providing a user with automatic conveying electrode.In some enforcements
In example, user equipment can allow a user to specify the level of electrode, to trigger automatic conveying.In certain embodiments, Yong Hushe
It is standby can also allow a user to specify will automatic conveying electrode amount.
Figure 12 according to one embodiment of present invention, shows user by controlling waveform sets to enter nerve stimulator
The flow chart of row control.In certain embodiments, the method for controlling waveform sets can include：In transcutaneous electrostimulation session
Period, from the user's computing device for being configured with application program waveform sets are run and control so that application program is stored in non-temporary
On state computer-readable medium, and can perform by computing device.Method can include allowing user on the user computing device
Select the subset of cognitive state.The method can include S100：Multiple waveform sets are presented to user using user equipment.Method
S110 can be included：User is allowed to select waveform sets on the user computing device.Method can include S120：User is allowed to set
It is standby to be communicated with nerve stimulator, and the parameter of the waveform sets that user is selected is transferred to nerve stimulator.Additionally, side
Method can include：In transcutaneous electrostimulation ession for telecommunication modulation waveform set.For example, method can include S130：User is allowed to exist
Neuroregulation ession for telecommunication controls waveform using at least one interactive component in user interface on the user computing device
Set.For example, method can include the perceptive intensity for allowing user that waveform sets are adjusted in neuroregulation ession for telecommunication.At some
In embodiment, method can include S140：User is allowed to share at least one element of waveform sets with Neuroregulators user.
In certain embodiments, method can alternatively include：User is allowed to trigger light in transcutaneous electrostimulation ession for telecommunication
Photis or booster or other predetermined signals.In certain embodiments, method can include：User is allowed via society
Hand over network web sites, be shared in the element of waveform sets at least by the communications framework of Email or any other type
One element.In certain embodiments, user can share before, during and/or after transcutaneous electrostimulation session element and/
Or the waveform of nesting.In certain embodiments, user equipment can generate user interface, dialog box or pop-up window, to carry
Show the element of users to share waveform sets.In certain embodiments, other friends and/or user can pass through Email, text
This, the user interface of social networking website or another type be sent to user with regard to his/her element and/or nesting
The request of waveform.
In certain embodiments, method can include that user is transferred to the control of neuroregulation equipment waveform sets parameter
Device.In certain embodiments, transmission can include preserving, derive, send Email, send text, upload, download or appoint
What other kinds of strategy for e-file being sent to identical or another position or virtual location and/or it is
System.In certain embodiments, waveform sets can be transferred to user's computing device (including kneetop computer, desktop computer, shifting
The computing device of mobile phone, panel computer or any other type).
In certain embodiments, method can include allowing user to set using in the first computing device or the second calculating
Waveform sets are controlled at least one interactive component in upper user interface.In certain embodiments, control can include
Add, remove, record, resequence, change, change, replace, exchange, and/or switch element and/or parameter.In some enforcements
In example, user can be controlled and/or be repaiied using the user interface of the user interface with network startup or any other type
Change transcutaneous electrostimulation session.In certain embodiments, waveform sets can be downloaded to into user's calculating as described above to set
It is standby.
The system of preferred implementation, apparatus and method and its modification can at least be realized and/or be embodied as being configured to connect
Receipts store a part for the machine of the computer-readable medium of computer-readable instruction.Instruction preferably can perform by computer
Part is performed, the executable part of the computer preferably with the system integration comprising the computing device using software arrangements.Meter
Calculation machine computer-readable recording medium can be stored on any suitable computer-readable medium, such as RAM, ROM, flash memory, EEPROM, optics
Equipment (for example, CD or DVD), hard disk drive, floppy disk or any suitable equipment.The executable part of computer is excellent
Selection of land is general processor or application specific processor, but, alternatively or additionally, any suitable specialized hardware or hardware/
The combination of firmware can carry out instruction.
When a feature or element are when " in another feature or element " is described herein as, it can be directly special at other
Levy or element on, also likely to be present centre another feature or element.Conversely, when a feature or element are described as " directly
It is connected on another feature or element " when, exist without middle feature or element.It should be appreciated that when a feature or element quilt
It is described as " connection ", " attachment " or during " coupled " in another feature or element, it can be directly connected to, be attached or coupled to it
His feature or element, or there may be the feature or element of centre.Conversely, when a feature or element be referred to as " being directly connected to ",
When " being directly attached " or " direct-coupling " is to another feature or element, exist without middle feature or element.Although with regard to one
Individual embodiment description illustrates feature and element, but feature so describing or illustrating and element are applicable to other enforcements
Example.It will be appreciated by those skilled in the art that the structure or feature with reference to the configuration of " neighbouring " another feature can have and adjacent feature
Overlap or the part below adjacent feature.
Terms used herein is intended merely to describe the purpose of specific embodiment, rather than intends to limit the present invention.For example,
In addition to context is clearly stated, as used herein, singulative " a (one) ", " an (one) " and " the (described) " be intended to together
Sample includes plural form.It is to be further understood that term " including (comprises) " and/or " including (comprising) " when
When using in this manual, it is intended that the presence of feature, step, operation, element and/or the part stated, but it is not excluded for depositing
Or add one or more of the other feature, step, operation, element, part and/or their group.As used herein, term
"and/or" includes any combination in the Listed Items of one or more correlation and all combinations, and can be abbreviated as "/".
The term of space correlation, such as " ... under (under) ", " ... under (below) ", " be less than (lower) ",
" ... upper (over) ", " top (upper) " etc. can be used herein, in order to describe an element as shown in drawings
Or feature is relative to the relation of other one or more elements or feature.It should be appreciated that the term of space correlation is intended to
The different directions of the equipment for using or operation in addition to the direction described in accompanying drawing.For example, if the equipment in accompanying drawing is
It is reverse, such as element be described as " under other elements or feature (under) ", " under other elements or feature
(beneath) ", then the element will be oriented to " (over) on other elements or feature ".Therefore, exemplary term
" ... under (under) " can cover ... and ... under two kinds of directions.The device (can be rotated by 90 ° by positioning in addition
Or in other directions), and correspondingly explain the description of space correlation used herein.Similarly, except other special instruction
Outside, term " (upwardly) upwards ", " downwards (downwardly) ", " vertical (vertical) ", " level
" etc. (horizontal) it is for the purpose of illustration herein.
Although term " first " and " second " are possibly used for describing various features/element (including step) herein,
It is that these features/elements should not be limited by these terms, unless otherwise indicated by context.These terms be likely to be used for by
A kind of features/elements are distinguished with another feature/element.Therefore, it is discussed below without departing from the teachings of the present invention
Fisrt feature/element can be referred to as second feature/element, and equally, second feature/element discussed below can be referred to as
One features/elements.
As used by herein in the specification and in the claims, be included in it is used in embodiment, unless otherwise clear and definite
Illustrate, all numerals can be read as seeming to start with word " about (about) " or " about (approximately) ", even if should
Term does not clearly occur.When describing size and/or during position, it is possible to use phrase " about (about) " or " about
(approximately) ", indicating described value and/or position in the range of the rational expectation of value and/or position.For example,
Digital numerical value can have the numerical value (or numerical range) ± 0.1% numerical value, ± the 1% of the numerical value (or numerical range)
Numerical value, the numerical value (or numerical range) ± 2% numerical value, the numerical value (or numerical range) ± 5% numerical value, institute
State ± 10% numerical value of numerical value (or numerical range) etc..Any numerical range mentioned herein is intended to include being included in
Whole subranges.
Although various exemplary embodiments are described above, without departing from this by described in claims
In the case of bright scope, any amount of change can be made to various embodiments.For example, wherein performing various described
The order of method and step generally can change in alternative embodiments, and in other alternate embodiments, can completely skip one
Individual or multiple method and steps.The optional feature of various equipment and system embodiment can be included in certain embodiments, and not
Including in other embodiments.Therefore, description above is provided mainly for exemplary purpose, and is not necessarily to be construed as limiting
The scope of the present invention stated in the claims.
The example and explanation for being included in this paper is illustrated by way of illustration, not of limitation wherein can be with the concrete of practical matter
Embodiment.As mentioned, it is possible to use and therefrom derive other embodiment so that without departing from the scope of the present disclosure
In the case of, the replacement and change of structure and logic can be made.For convenience's sake, such embodiment of present subject matter is at this
Wen Zhongke is only separately or cooperatively quoted by term " invention ", and if in fact disclosed more than one, it is no intended to will
Scope of the present application is actively restricted to any single invention or inventive concept.Therefore, although illustrated herein
Can be substituted by shown specific embodiment with any arrangement for describing specific embodiment, but calculating to realize identical purpose.
The disclosure is intended to any and all modifications or the modification of various embodiments.On the basis of description above is read,
Above-described embodiment will be apparent with the combination of the other embodiments not specifically described herein to those skilled in the art.
Claims (61)
1. a kind of method of the cognitive state that the user is changed using the nerve stimulator being worn on the head of user, described
Method includes：
The user is allowed to select waveform sets from multiple waveform sets on a user device；
Identifier corresponding with selected waveform sets or one group of parameter are transmitted to the institute of the head for being worn on the user
State nerve stimulator for the waveform sets applying；And
The user is allowed to adjust applied waveform sets using the user equipment during the applying of the waveform sets
Perceptive intensity.
2. a kind of method that nerve stimulator using the head for being worn on user changes the cognitive state of the user, the side
Method includes：
Multiple waveform sets are presented to user using hand-held consumer devices；
The user is allowed to select waveform sets from the plurality of waveform sets；
Identifier corresponding with selected waveform sets or one group of parameter are transmitted to the institute of the head for being worn on the user
State nerve stimulator；
Apply the waveform sets from the nerve stimulator, to change the cognitive state of the user；And
The user is allowed to adjust applied waveform sets using the user equipment during the applying of the waveform sets
Perceptive intensity.
3. a kind of method that nerve stimulator using the head for being worn on user changes the cognitive state of the user, the side
Method includes：
The user is allowed to select waveform sets from multiple waveform sets on a user device；
Identifier corresponding with selected waveform sets or one group of parameter are transmitted to the nerve for being worn on user's head
Stimulator for the waveform sets applying；And
On the user equipment, the maximum perceptive intensity of the waveform sets that will be transmitted by the nerve stimulator is shown
Expression；
When the waveform sets are put on the user by the nerve stimulator, it is allowed to which the user adjusts the ripple
The perceptive intensity for being applied of shape set；And
The expression of adjusted perceptive intensity is shown in the expression of the maximum perceptive intensity of the waveform sets.
4. the method according to claim 1,2 or 3, also is being configured to arouse class cognition shape including the permission user
Selected in the subset of the waveform sets of state.
5. the method according to claim 1,2 or 3, is additionally included in the user equipment and receives from nerve stimulator
Indicating electrode has been attached to the signal of the nerve stimulator.
6. the method according to claim 1,2 or 3, is additionally included in the user equipment and receives from nerve stimulator
Indicating electrode has been attached to the signal of the nerve stimulator, and based on the letter received from the nerve stimulator
Number determine the type of the electrode.
7. the method according to claim 1,2 or 3, also including allowing the user in the plurality of waveform sets
Waveform sets carry out ranking or marking, and store, transmit or store and transmit user's ranking or marking.
8. the method according to claim 1,2 or 3, also described including allowing the user that new waveform sets are downloaded to
User equipment.
9. the method according to claim 1,2 or 3, also including the ranking or marking shown with regard to the waveform sets.
10. the method according to claim 1,2 or 3, also including allowing applying phase of the user in the waveform sets
Between trigger interrupt signal to the transmission of the nerve stimulator from the user equipment, wherein, the interrupt signal is fixed in advance
Change the applying of the waveform sets in the timer period of justice temporarily.
11. methods according to claim 1,2 or 3, are also applying including the permission user described in the waveform sets
Plus period triggers interrupt signal to the transmission of the nerve stimulator from the user equipment, wherein, the interrupt signal is pre-
Change the applying of the waveform sets in the timer period for first defining temporarily, also, wherein, the interrupt signal is matched somebody with somebody
It is set to and arouses phosphene.
12. methods according to claim 1,2 or 3, also including allowing the applying phase of the user in the waveform sets
Between trigger interrupt signal to the transmission of the nerve stimulator from the user equipment, wherein, the interrupt signal is fixed in advance
The applying of the waveform sets is changed temporarily to trigger in the timer period of justice, also, wherein, the interrupt signal quilt
It is configured to the instantaneous perceptive intensity for reducing and then increasing or be instantly increased and then reduce the waveform sets.
13. methods according to claim 1,2 or 3, being additionally included in display on the user equipment is included for using
State the video of the instruction of nerve stimulator.
14. methods according to claim 1,2 or 3, also include by near real-time being shown on the user equipment come
Enable the user to observe the image of the head of the user from the image of camera, it is described so as to allow the user to confirm
Nerve stimulator, electrode or nerve stimulator and electrode position.
15. methods according to claim 1,2 or 3, also including the quantity for estimating the electrode that the user has automatically, and
And the request of extra electrode is bought in prompting on the user equipment.
16. methods according to claim 1,2 or 3, the waveform sets for also being carried out by the user including tracking
Apply, including adjustment of the user to the perceptive intensity.
17. methods according to claim 2, wherein, the plurality of waveform sets are presented to be included indicating in the plurality of ripple
The history use information of each waveform sets in shape set, including adjustment of the user to the perceptive intensity of the waveform.
18. methods according to claim 2, wherein, the plurality of waveform sets of presentation include being based on to be done by other users
The ranking that goes out or marking are indicating ranking or marking the information of each waveform sets in the plurality of waveform sets.
19. methods according to claim 2, wherein, the plurality of waveform sets of presentation include being based on is produced by the user
Raw ranking or marking are indicating ranking or marking the information of each waveform sets in the plurality of waveform sets.
A kind of readable storage medium of 20. non-transient computers, its storage can be by computing device controlling what is dressed by user
One group of instruction of the operation of nerve stimulator, and one group of instruction is when by the computing device so that the process
Device：
One group of waveform sets for being configured to the cognitive state for changing the user are presented to the user；
Allow the user that a waveform sets are selected from one group of waveform sets；
The waveform sets parameter is transferred to the nerve stimulator, for being carried out to the use by the nerve stimulator
The applying of the head at family；And
Allow the user that the perceptive intensity of applied waveform sets is adjusted during the applying of the waveform sets.
A kind of readable storage medium of 21. non-transient computers, its storage can be by computing device controlling what is dressed by user
One group of instruction of the operation of nerve stimulator, and one group of instruction is when by the computing device so that the process
Device：
One group of waveform collection for being configured to the cognitive state for changing the user is shown on the screen being connected with the processor
Close；
Allow the user that a waveform sets are selected from shown one group of waveform sets；
The waveform sets are transferred to the nerve stimulator from the Wireless Transmitter being connected with the processor, for by
The nerve stimulator carries out the applying of the waveform sets to the head of the user；And
The control that startup is connected with the processor, wherein, the user can adjust during the applying of the waveform sets
The control is changing the perceptive intensity of applied waveform sets.
The readable storage medium of 22. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, the processor is also caused to allow the user from basis by each ripple in the waveform sets
Waveform sets are selected in the subset of the waveform sets that the cognitive state that shape set is aroused is grouped.
The readable storage medium of 23. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, also cause the processor to receive indicating electrode from the nerve stimulator and be attached to the god
The signal of Jing stimulators.
The readable storage medium of 24. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, also cause the processor to receive indicating electrode from the nerve stimulator and be attached to the god
The signal of Jing stimulators；And the type of the electrode is determined according to the signal from the nerve stimulator.
The readable storage medium of 25. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, the processor is also caused to allow the user to carry out ranking to the waveform sets transmitted or beat
Point, and store, transmit or store and transmit the ranking or marking.
The readable storage medium of 26. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, the processor is also caused to allow the user to download new waveform sets.
The readable storage medium of 27. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, the ranking of waveform sets or beat that the processor is displayed in one group of waveform sets are also caused
Point.
The readable storage medium of 28. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, also allow the user that interrupt signal is transferred to institute during the applying of the waveform sets
Nerve stimulator is stated, wherein the interrupt signal changes the institute of the waveform sets in predetermined timer period temporarily
State applying.
The readable storage medium of 29. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, also allow the user that interrupt signal is transferred to institute during the applying of the waveform sets
Nerve stimulator is stated, wherein the interrupt signal changes the institute of the waveform sets in predetermined timer period temporarily
Applying is stated, to arouse phosphene.
The readable storage medium of 30. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, also allow the user that interrupt signal is transferred to the god during the applying of the waveform sets
Jing stimulators, wherein the interrupt signal is configured to instantaneous reduction and then increasing or being instantly increased and then reduce the waveform
The perceptive intensity of set.
The readable storage medium of 31. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, the processor is also caused to show including for using the video of the instruction of the nerve stimulator.
The readable storage medium of 32. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, the processor near real-time ground is also caused to show the figure from the camera being connected with the processor
Picture so that the user can observe the image of the head of the user.
The readable storage medium of 33. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, also cause the processor to estimate the quantity of the electrode that the user has automatically, and point out institute
State user and buy extra electrode.
The readable storage medium of 34. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, the processor is also caused to track the applying of the waveform sets carried out by the user, including
Adjustment of the user to the perceptive intensity.
The readable storage medium of 35. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, the processor is also caused to indicate the past of each waveform sets in one group of waveform sets
Use information, including adjustment of the user to the perceptive intensity of the waveform.
The readable storage medium of 36. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
During the computing device, also cause the processor based on the ranking or marking made by other users, indicate described one
Ranking or marking the information of each waveform sets in group waveform sets.
The readable storage medium of 37. non-transient computers according to claim 20 or 21, wherein, one group of instruction by
Also cause the processor based on the ranking or marking made by the user during computing device, indicate at described one group
Ranking or marking the information of each waveform sets in waveform sets.
A kind of method of the 38. utilization user equipment control nerve stimulators in order to change the cognitive state of user, methods described
Including：
During the stimulation cycle, wirelessly and periodically passed to nerve stimulator from the user equipment with very first time interval
Defeated waveform sets parameter；
By wireless from the nerve stimulator in the user equipment less than second time interval at very first time interval
Ground receives confirmation signal；And
If the user equipment is not received by the confirmation signal, stop the transmission to the waveform sets parameter.
A kind of method of the 39. utilization user equipment control nerve stimulators in order to change the cognitive state of user, methods described
Including：
The signal that the indicating electrode from nerve stimulator has been attached to the nerve stimulator is received in a user device；
Wirelessly and periodically passed to nerve stimulator from the user equipment with very first time interval during the stimulation cycle
Defeated waveform sets parameter；
With wireless from the nerve stimulator in the user equipment less than second time interval at very first time interval
Ground receives confirmation signal；And
If the user equipment is not received by the confirmation signal, stop the transmission to the waveform sets parameter.
40. methods according to claim 39, are also included according to the signal from the nerve stimulator determines
The type of electrode.
41. methods according to claim 38 or 39, are also included using the lumped parameter received from the user equipment, from
The nerve stimulator applies nerve stimulation to the user.
42. methods according to claim 38 or 39, are additionally included in the user equipment receipt source in the nerve
The signal of contact of the instruction of stimulator between the user and the electrode of the nerve stimulator.
43. methods according to claim 38 or 39, are additionally included in the user equipment receipt source in the nerve
The signal of contact of the instruction of stimulator between the user and the electrode of the nerve stimulator, wherein, connect described in instruction
The tactile signal is coded among the confirmation signal of the nerve stimulator.
44. methods according to claim 38 or 39, are additionally included in the user equipment receipt source in the nerve
The signal of impedance of the instruction of stimulator between the electrode of the user and the nerve stimulator, wherein, indicate the resistance
Anti- signal is once received with about per minute.
45. methods according to claim 38 or 39, wherein, it is spaced from the use with the very first time during the stimulation cycle
To nerve stimulator, wirelessly and periodically transmitted waveform lumped parameter includes family equipment：With 300 milliseconds to 500 milliseconds it
Between interval transmission portion waveshape lumped parameter.
46. methods according to claim 38 or 39, wherein, it is spaced from the use with the very first time during the stimulation cycle
To nerve stimulator, wirelessly and periodically transmitted waveform lumped parameter includes family equipment：Passed with about 400 milliseconds of interval
Defeated portion waveshape lumped parameter.
47. methods according to claim 38 or 39, wherein, with less than second time interval at very first time interval
Wirelessly receiving confirmation signal from the nerve stimulator in the user equipment includes：In the user equipment every about
100 milliseconds once wirelessly receive the confirmation signal.
48. methods according to claim 38 or 39, be additionally included in from the user device transmissions waveform sets parameter it
Before, the user equipment is matched with the nerve stimulator.
49. methods according to claim 38 or 39, also include：Passing to the nerve stimulator from the user equipment
Before defeated waveform sets parameter, the waveform sets parameter is encrypted.
The method that a kind of 50. nerve stimulators using the head for being worn on user change the cognitive state of the user, it is described
Method includes：
The maximum sense of the waveform sets that will be transmitted by the nerve stimulator is shown on wearable or hand-held user equipment
Know the expression of intensity；
When the waveform sets are put on the user, it is allowed to which the user is adjusted by the nerve from the user equipment
The perceptive intensity for being applied of the waveform sets that stimulator is applying；And
The expression of the perceptive intensity of adjusted applying is shown in the expression of the maximum perceptive intensity of the waveform sets.
51. methods according to claim 50, wherein, show that the expression of maximum perceptive intensity will be by the god including display
The expression of the maximum perceptive intensity of the whole waveform sets of Jing stimulators transmission.
52. methods according to claim 50, wherein, showing the expression of maximum perceptive intensity is included the maximum perception
The expression of intensity is shown as linear display, wherein the expression for the described maximum perceptive intensity of the waveform sets is arranged to
The form of line.
53. methods according to claim 50, wherein, showing the expression of maximum perceptive intensity is included whole waveform sets
The expression of described maximum perceptive intensity be shown as ring, wherein, the expression of the maximum perceptive intensity of the starting point of the waveform sets
It is adjacent to show with the expression of the maximum perceptive intensity of the terminal of the waveform sets.
54. methods according to claim 50, wherein allowing the user to adjust the sense for being applied of the waveform sets
Know that intensity includes：Control is presented on the display of the user equipment, to adjust applied perceptive intensity.
55. methods according to claim 50, wherein allowing the user to adjust the sense for being applied of the waveform sets
Know that intensity includes：When the applied perceptive intensity of user adjustment downwards, with the intensity that first rate lowers the waveform,
And when the user adjusts upward applied perceptive intensity, with the intensity that the second speed raises the waveform, wherein, it is described
First rate is faster than second speed.
The method that a kind of 56. nerve stimulators using the head for being worn on user change the cognitive state of the user, it is described
Method includes：
In multiple time intervals, show the moment of the waveform sets transmitted by the nerve stimulator in hand-held consumer devices
The expression of peak value perceptive intensity；
When the waveform sets are put on the user, it is allowed to which the user is selected by the control from the user equipment
The percentage ratio of the peak value perceptive intensity is selected, to adjust by described in the nerve stimulator is applying from the user equipment
The perceptive intensity for being applied of waveform sets；And
Apply the waveform sets when, each time interval the transient peak perceptive intensity of the waveform sets expression
The upper expression for showing adjusted perceptive intensity.
57. methods according to claim 56, wherein, show the expression bag of the transient peak perceptive intensity of the waveform
Include：Show the expression of the transient peak perceptive intensity of the whole waveform sets that will be transmitted by the nerve stimulator.
58. methods according to claim 56, wherein, show the expression bag of the transient peak perceptive intensity of the waveform
Include：The expression of the transient peak perceptive intensity is shown as linear display, wherein, perceive with regard to the maximum of the waveform sets
The expression of intensity is arranged to the form of line.
59. methods according to claim 56, wherein, show the expression bag of the transient peak perceptive intensity of the waveform
Include：The expression of the transient peak perceptive intensity of whole waveform sets is shown as ring, wherein, the wink of the starting point of the waveform sets
Between expression and the expression of the transient peak perceptive intensity of the terminal of the waveform sets of peak value perceptive intensity be adjacent to show.
60. methods according to claim 56, wherein, it is allowed to the user adjusts the sense for being applied of the waveform sets
Know that intensity includes：Present on the display of the user equipment for adjust the button of applied perceptive intensity, slider bar,
Or rotating disk.
61. methods according to claim 56, wherein, it is allowed to the user adjusts the sense for being applied of the waveform sets
Know that intensity includes：The intensity that the waveform is lowered with first rate when user adjustment downwards applied perceptive intensity,
And the intensity of the waveform is raised with the second speed when the user adjusts upward the applied perceptive intensity, its
In, the first rate is faster than second speed.
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| PCT/US2015/018090 WO2015131093A1 (en) | 2014-02-27 | 2015-02-27 | Methods and apparatuses for user control of neurostimulation |
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| EP (1) | EP3110497A4 (en) |
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| CN118662784B (en) * | 2024-08-23 | 2024-12-03 | 中国科学院自动化研究所 | Multi-brain-area nerve stimulation system and control method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| US9968780B2 (en) | 2018-05-15 |
| WO2015131093A1 (en) | 2015-09-03 |
| US9399126B2 (en) | 2016-07-26 |
| EP3110497A1 (en) | 2017-01-04 |
| EP3110497A4 (en) | 2018-12-05 |
| US20160317809A1 (en) | 2016-11-03 |
| US20150238762A1 (en) | 2015-08-27 |
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