CN106535966A

CN106535966A - Handheld medical substance dispensing system, apparatus and methods

Info

Publication number: CN106535966A
Application number: CN201580039430.7A
Authority: CN
Inventors: 霍华德·S·苏特金; 杰里·博特金
Original assignee: Akunite Co Ltd
Current assignee: Akunite Co Ltd
Priority date: 2014-05-23
Filing date: 2015-05-22
Publication date: 2017-03-22
Also published as: JP2017518858A; EP3145566A1; EP3145566A4; WO2015179783A1; KR20170019368A

Abstract

Various handheld medical dispensing configurations and methods including the following: Handheld medical dispensing system comprises a syringe, which has a plunger, releasably mounted to syringe actuation apparatus, the apparatus having an actuator configured such that it can move the plunger more than once to dispense a plurality of amounts of substance from the syringe and having a housing adapted for singled handed administration of an injection. A method of dispensing fluid from a syringe comprises holding a medical substance delivery system including a syringe, which has a needle, and which is secured to syringe actuation apparatus configured to dispense predetermined amounts of the substance from the syringe, penetrating the needle at one patient site and using the apparatus to deliver a predetermined amount of the substance, and penetrating the needle at another patient site and using the apparatus to deliver a predetermined amount of the substance.

Description

Hand-held medical physical distribution system, apparatus and method

Related application

The application is the continuity of No. 14/286,701 U. S. application No.14/286,701 that on May 23rd, 2014 submits to Case, which is the cip application of the 13/550th, No. 473 U. S. application that on July 16th, 2012 submits to.The application or 2014 The continuity case of the 14/481st, No. 708 U. S. application that September is submitted on the 9th, which is the 14/286 for submitting on May 23rd, 2014, The cip application of No. 701 U. S. applications, the cip application of the 14/286th, No. 701 U. S. application are to carry on July 16th, 2012 The cip application of No. 13/550,473 U. S. application handed over.The full content of each in above-mentioned application is by quoting simultaneously Enter herein.

Background of invention

In field of orthopedic surgery, non-invasive procedures (non-invasive procedure) are in the past decade increasingly by joyous Meet.Modal operation is included in facial line and wrinkle injecting fluid implant and using making facial muscle optionally numb The medicament of numbness is providing the reduction of wrinkle and smooth.Generally, dermal filler or paralysis medicament, such as BOTOX (Botox.RTM.Cosmetic (onabotulinumtoxinA)) is used for regular outpatient.These medicaments are generally with jelly The sterile vials product of dry form can be obtained.Basis is added to clinician the spy of the Sterile Saline (fluid) in product bottle Determine formula and carry out reconstituted formula.Once mixing, by preparation inhalation syringe, carries out subcutaneous delivery using small-bore medical needle.Most Disposable syringe of the common delivering method using a milliliter that disposable aspiration needle is housed.Importantly, will by multiple injection A small amount of reproducible fluid distribution thing is delivered to the muscle (for example, by the frontalis in the facial zone benefited from treatment) of face In.

Further, it is known that during face injection, the main body to being sitting on chair uses little syringe for medical care Personnel are typically uncomfortable, and undergo syringe not due to must push on positioned at the plunger of the rear end of injector assembly Stable operation, so while attempt to keep syringe steady.Therefore, there is a kind of demand in such application, the demand is used In provide more stable handheld dispensers or syringe or from handheld dispensers or syringe provide desired filler or The amount of fluid, to obtain predictable and/or desired result.

Summary of the invention

The present invention relates to the improvement of medical treatment material delivery system, and can be used for delivering any material.As one Example includes the pharmaceutical substance delivery system for treating facial line and/or wrinkle.

One modification of devices disclosed herein includes the allocation unit for being used together with syringe.For example, it is such Equipment can include the syringe with cylinder and relative to cylinder slidably to distribute the plunger of the material in cylinder, doctor Included with distribution system：Casing assembly, which is configured to the cylinder of non-movable piston so that the distal end adjacent housings component of cylinder Distal end；Drive mechanism, which is connected to casing assembly, and drive mechanism includes the plunger counterpart of engagement pistons；Actuator；And tooth Wheel drive component, which is connected between plunger counterpart and actuator, and gear drive component is configured to respond to the shifting of actuator It is dynamic and move so that plunger counterpart produces on the first direction relative to the distal end of shell it is mobile and it is subsequent with first party Movement is produced in contrary second direction.

The modification of allocation unit includes gear drive component, and the gear drive component makes post in the single stroke of actuator Plug counterpart is moved in a first direction, and subsequent mobile plunger counterpart in a second direction.In addition, in some modifications In, a part of of gear drive component can depart from so that actuator single stroke inner plunger counterpart in second direction Upper movement.

As noted herein, allocation unit disclosed herein can include gear drive component, and the drive component includes At least first gear structure and second gear structure, first gear structure are configured to make plunger counterpart produce in a first direction Raw movement, second gear structure are configured to make plunger counterpart produce movement in a second direction；And the wherein list of actuator Individual stroke includes first paragraph and second segment, and wherein actuator movement in the first paragraph causes the movement of first gear structure, and Movement of the actuator in second segment causes the movement of second gear structure.In other modification, gear drive component is being caused Mobile period in the second segment of dynamic device departs from first gear structure.

As discussed herein, the modification of allocation unit can be using the gear train of one or more rack-and-pinions Part.But, any such mechanism can be used to achieve same result.

The example of allocation unit includes one or more first gear structures, and the first gear structure can be released by first axle It is connected to actuator with putting so that actuator causes first axle and actuator to disengage connection by the movement of first paragraph to second segment Connect.In other modification, second gear structure can be departed from till actuator moves through first paragraph with actuator.

In another modification, allocation unit can include：Syringe, the syringe have cylinder and can relative to cylinder The plunger of the material slided to distribute in cylinder；Casing assembly, which is configured to the cylinder of non-movable piston so that cylinder The distal end of distal end adjacent housings component；Drive mechanism, which is connected to casing assembly, and the drive mechanism includes the plunger of engagement pistons Counterpart；Actuator；And gear drive component, which is connected to plunger counterpart and actuator, and the gear drive component is matched somebody with somebody It is set to the movement of responsive actuation device and moves, so that plunger counterpart produces shifting on the first direction relative to the distal end of shell Move and subsequently produce movement in a second direction that is opposite the first direction.

The disclosure also includes the method that material is injected into patient.In one example, the method includes：Syringe is adjacent The tissue site positioning of nearly patient, the intubation that the syringe has the plunger for being connected to cylinder and extends from cylinder；Intubation is pushed away Enter in tissue site；Drive mechanism of the actuation linkages to syringe, wherein drive mechanism are configured to make plunger and cylinder exist During the actuating in the single direction of the actuator of drive mechanism, in a first direction and subsequently in the second party contrary with first direction It is moved relative to each other upwards.

In another modification, the method may include the method for implementing the injection that material enters patient, such as by noting Injection device is positioned adjacent to the tissue site of patient, and the injection device has reservoir and intubation, and the reservoir is carried and can be slided in reservoir Dynamic plunger, intubation extend from cylinder；Intubation is advanced in tissue site；One-handed actuation bar increases institute to cause plunger first State the volume of reservoir and subsequently cause plunger to reduce the volume of reservoir, patient is entered with delivered substance.

Another modification of equipment of the invention includes the equipment for injection mass to be delivered to tissue regions, its In the equipment include：Reservoir, which is configured to preserve material；Plunger, which is connected to reservoir so that the mobile change reservoir of plunger Volume；Intubation, which is fluidly connected to reservoir in far-end, and the intubation is configured to be pierced in tissue regions；Actuator, its Plunger is mechanically coupled to, wherein the actuator is configured to delivery location be moved to from resting position, wherein actuator is from quiet The movement of the part that stop bit is put makes plunger produce movement, and the shifting that wherein actuator continues towards delivery location in a first direction Dynamic to make the plunger produce movement in a second direction, wherein first direction and second direction is contrary.

Any feature or multiple features of any embodiment or modification can be with another embodiment or any spy of modification Levy or multiple combinations of features, regardless of whether it is preferred that.For example, any embodiment or modification can be with any one in following characteristics Individual or combination：Syringe plunger and the actuation means with actuator, the actuator make syringe plunger movement more than once with Distribute the material of multiple quantity (or volume)；Securing member, for being fixed to actuated syringes device by syringe；Note with pin Emitter；Syringe plunger and actuator, actuator include the pusher of pushing syringe plunger；Including actuator or drive component Actuator, the actuator or drive component are connected to syringe plunger pusher to drive pusher and/or plunger；Including bar Actuator, the bar is pivotally coupled to actuated syringes device to activate actuator or drive component；With cylinder and bar Syringe, distal end of the bar with and radial separation adjacent with the distal portions of cylinder；Bar with distal end and have cylinder and The syringe of pin, wherein bar are in non-overlapped relation (for example, through its whole stroke) with pin；Stopper element, which is connected to Actuated syringes device and there is contact portion in predetermined position, with the propulsion for limiting bar come from syringe distribution it is predetermined (or It is desired or default) material of quantity (or volume)；Stopper element, which is connected to actuated syringes device and has contact site Point, the contact portion has adjustable position and provides variable default stop with the propulsion to bar so that from syringe distribution The material of predetermined (or expecting or default) quantity (or volume) can change；The position of traveling limiting device be it is adjustable, with The traveling of adjusting lever so that can from syringe distribute multiple and variable predetermined (desired or default) quantity (or Volume) material；Actuator, its be configured to from multiple predetermined (the desired or default) quantity of syringe distribution (or Volume) material or distribute the material of different predetermined (desired or default) quantity (or volumes) from syringe；Note Emitter actuation means, which has syringe mounted thereto, is configured so that the actuated syringes device can be held in Only operated in one hands of user and with the handss or used；The syringe of medicine is accommodated, which is used for facial line and/or wrinkle Treatment；Reusable actuated syringes device；Actuated syringes device with multiple Syringe supports, syringe It is mounted or is fixed in the Syringe support；Actuated syringes device with surface (for example, the surface of curved shape), Syringe is mounted or fixes on a surface；Or the actuation means that syringe is releasably attached.

Additionally, dose or dosage can be the amounts of material.

The disclosure also includes being used together with syringe and being configured to permit by user one-handed actuation to deliver note The allocation unit penetrated.For example, in such systems, syringe can include cylinder and plunger, and plunger is to slide relative to cylinder The dynamic material to be distributed in cylinder by intubation；Allocation unit can include shell, the shell have be connected to thereon Drive mechanism, the drive mechanism includes actuator, and actuator makes gear assembly movement to advance plunger counterpart；Shell includes Load surface, base surface, bar side face and support side, wherein：Load table face includes window, wherein window exposure driving group Part, to allow to inject in shell syringe in the way of the longitudinal axis with shell align so that the distal end of cylinder is neighbouring outer The distal end of shell and intubation extend beyond the distal end of shell, and wherein the plunger of syringe is pieceable with plunger counterpart；Base Portion surface is configured to keep shell when being positioned on the surface of outside in static position, and when through window connection injection Allow to keep the stability of shell during device；At least multiple recesses, which has curve form on shell, and the plurality of recess includes base Portion's recess and support recess, base portion recess are located at base surface, support recess along support side from base portion recess towards shell Remote extension；And wherein support recess and base portion recess to be oriented to allow thumb and tiger's jaw (dorsal web) phase of user That what is answered is embedded, and the end of forefinger engages actuator and when forefinger moves actuator towards the distal orientation.

Allocation unit can also include at least one distal recess, and at least one distal recess is in bar surface and adjacent Near to load surface, wherein the distal recess allows the middle finger of the handss from user on the side relative with support housing to shell The application of applying power.

In another modification, the shell of distribution can include that one or more are located at least one of multiple recesses One or more indicants on recess, to allow the identification to recess.This indicant may include tactile or vision finger Show thing.

The other modification of shell may include at least one orientation force surface, and at least one orientation force surface is substantially horizontal To in the longitudinal axis of shell so that when inserting or removing intubation from patient, user can apply normal force to the orientation force Surface.Alternatively or in combination, the shell of allocation unit may include bar recess, and the bar recess has at least one orientation force table Face, at least one orientation force surface extend substantially transversely to the longitudinal axis of shell so that when from patient insert or remove intubation When user may be rubbed against the orientation force surface and push or pull on.

In another modification, shell can also include bar recess, and the bar recess is along bar side face from base portion recess direction The remote extension of shell, wherein the bar recess allow forefinger embedded on the actuator side of shell.

Additionally, the modification of housing main body can include guide recess, the guide recess be located at shell actuator side and Adjacent distal end, wherein the guide recess allow the embedded of the end of other finger, with further steady during mobile actuator Determine shell.

The modification of equipment can include the actuator surface for being connected to actuator, and wherein this actuator surface can include The indicant recognized by which.

The shell being discussed herein can with it is being discussed herein or be connected similar to the arbitrary drive component being discussed herein.

In another modification, the disclosure includes the method for being injected into patient for part material, and the method includes：Will injection Device is positioned adjacent to the tissue site of patient, and the syringe is fixed on the shell with drive mechanism, and drive mechanism includes causing Dynamic device, the actuator make gear assembly movement to advance plunger counterpart to be connected to the plunger of syringe；Wherein shell includes dress Carry surface, base surface, bar side face and support side and at least multiple recesses, the plurality of recess has curved on shell Shape, the plurality of recess includes base portion recess and supports recess, and base portion recess is located in base surface, supports recess along support-side Remote extension of the face from base portion recess towards shell；And shell is grasped with singlehanded so that the thumb of handss and tiger's jaw are respectively embedded in Support in recess and base portion recess, to allow singlehanded propulsion syringe to enter patient, and allow the end of forefinger to engage actuator And distal orientation is retained towards when forefinger moves actuator to perform injection.

It is more than the brief description to some defects of the prior art and advantages of the present invention.Describe and attached from following Figure, the further feature of the present invention, advantage and embodiment will be apparent to those of ordinary skill in the art, and wherein be merely to illustrate Purpose, the present invention concrete form show in detailed description in detail.Access device (access device) described herein and The modification of process includes the combination of the feature of various embodiments or the combination of embodiment itself in the conceived case.

Brief description

Fig. 1 is the decomposing schematic representation of the held dispensing systems (or device) of an embodiment of the invention.

Fig. 2 schematically illustrates the side view of the embodiment of Fig. 1 of assembling, and wherein syringe installs system in FIG Actuated syringes device on and actuation means pusher member separate with syringe plunger.

The system that Fig. 3 schematically illustrates Fig. 2, the lever arm for wherein illustrating partly is depressed so that pusher member is engaged Syringe plunger thumb portion simultaneously advances syringe plunger, makes device be to use to do to spray a small amount of liquid from syringe needle It is good to prepare.

The system that Fig. 4 schematically illustrates Fig. 3 from opposite side, and discharged in lever arm and allowed to return to such as Fig. 2 institutes After its starting shown or resting position, and the system is pushed into towards the target site on patient skin.

The system that Fig. 5 schematically illustrates Fig. 4, the system operator or doctor sticked a needle into patient skin it Afterwards, lever arm and is fully depressed to engagement bar stopper element to distribute intended volume or default and/or predetermined body from syringe Long-pending material.

The system that Fig. 6 schematically illustrates Fig. 5, the system is after the pin of system is removed from patient, and lever arm quilt Discharge and allow to return to its starting as shown in Figure 4 or resting position.

Fig. 7 A are the schematic partial sections intercepted approximately along the line 7A-7A in Fig. 2.

Fig. 7 B are the schematic plans of the shell illustrated in Fig. 7 A, are shown secured to the framework of actuated syringes device Or the side wall of outer shell edge of base portion.

Fig. 7 C are the schematic plans of the shutdown device or component for the lever arm as described by example in Fig. 1.

Fig. 7 D are the generally schematic enlarged partial sectional views of the relieving mechanism of schematic representation in Fig. 7 A.

Fig. 7 E schematically illustrate the promoting button in Fig. 7 D that have rotated 180 degree and lever arm.

Fig. 7 F schematically illustrate the cross section view that the line 7F-7F generally in Fig. 7 D is intercepted.

Fig. 8 A schematically illustrate the generally shown in fig. 7 ratchet mechanism for advancing pusher member.

Fig. 8 B schematically illustrate the mechanism in Fig. 8 A, and the ratchet rotation and pusher member in wherein Fig. 8 A is advanced.

Fig. 8 C schematically illustrate the mechanism in Fig. 8 B, and the ratchet in wherein Fig. 8 A is further rotated and pusher member is entered One step is advanced.

Fig. 8 D schematically illustrate the mechanism in Fig. 8 C, and its median claw is moved inward and pusher member is reset or retracts.

Fig. 9 schematically depict a method with the system in Fig. 2 that is hold by one hand.

Figure 10 illustrates the axonometric chart of the modification of allocation unit, and the allocation unit is configured to the thing in delivering storage reservoir Negative pressure is produced in cylinder or reservoir before the content of matter.

Figure 11 A and Figure 11 B show the corresponding front view and rearview of equipment 100 in Figure 10.

Figure 12 A to Figure 12 E show the example of the gear drive component during actuator is by the movement of the first trip segment.

Figure 12 F show the disengaging of anti-driven gear mechanism.

Figure 13 shows the bottom view of the modification shown in Figure 10.

Figure 14 A to Figure 14 C illustrate the propulsion that the movement of actuator causes plunger counterpart.

Figure 15 A and Figure 15 B show another modification of equipment, wherein cylinder relative to plunger movement forming negative pressure.

Figure 16 shows another modification for the element for being used for being used together with injecting systems including shell and circuit.

Figure 17 A to Figure 17 E illustrate another modification of the allocation unit with improved shell, and which improves user behaviour Make the singlehanded ability placed and activate of unit.

Figure 18 A and Figure 18 B illustrate the shell of Figure 17 A-17E and how to facilitate implementation the one-handed performance of injecting unit and show Example.

Figure 19 A to Figure 19 C illustrate the various views of another modification of shell, and the various mark parts of wherein shell are intended to By handss or the finger engagement of user.

Figure 20 illustrates another related design, and which is included for the conventional syringe and/or injecting systems one with the disclosure Act the sensing unit for using.

Figure 21 illustrates another related design, and which is included for the conventional syringe and/or injecting systems one with the disclosure Act the holding unit for using.

Describe in detail

Before describing the present invention, it should be appreciated that the present invention is not intended to be limited to described specific embodiment Or example, because these embodiments or example are it is of course possible to changing.Additionally, when referring to the figures, similar labelling represents phase As element.

An embodiment of the invention, hand-held medicine or medical treatment material delivery system (or device) include Actuation means and the allotter (for example, syringe) of medical or medical treatment, actuation means can be mechanical actuation means, wherein divide Orchestration install or be connected to actuation means so that people grip material delivery system when, can with manually handle actuation means from Allotter delivered substance (for example, for treat any suitable medicine or medicament of facial line and wrinkle, such as paralyzant) is to suffering from Person position or target site (for example, Musclar layer immediately below skin) or each in multiple patient positions or target site It is individual.Actuation means are configured to operator and provide motility at the aspect of the amount of delivered substance, such as by allowing operation Person determines the degree that actuation means activated.For example, operator does not need fully actuated actuation means so that small amount or volume Material be allocated.Actuation means may be additionally configured to allow operator to deliver desired, default or predetermined amount or volume Material.Actuation means may be additionally configured to facilitate implementation the material of desired, the default or predetermined amount of identical or volume Repeatable delivering, this can facilitate implementation from allotter the material for delivering reproducible precise volume or volume.Accurate amount can With the drop for example corresponding to liquid, the size wherein dripped can depend on density and the ambient pressure (surrounding of liquid Pressure), or a value, such as the 0.1 of material milliliter.By contrast, syringe is gripped using handss and use another The thumb of handss or the same hand depresses traditional method (if possible) of plunger, the accurate reproducible amount of delivering or body Long-pending material is probably difficult.

Additionally, the actuation means described in the preceding paragraph can be provided with optional adjustment mechanism, in order to realize delivering The material of different desired, default or predetermined amounts (or volume) or different doses or dosage.

Material delivery system may be additionally configured to be hold by one hand and use (for example, by similar to grip pen in the way of), This can be with strengthening system controllability during use and stability.(for example, the one-handed performance of this external system allows its user Operator or doctor) other things are done using his/her idle handss.For example, it is when using the systematic treating wrinkle, single Handss operation allows the handss of the free time of user to keep the skin of patient and in crumple zone stretched skin, and this contributes to using another Handss deliver the correct placement of medicament.Therefore, using the construction, medicament can be gripped using singlehanded (or only needing one hand) or material is passed System is sent, the system is operated to desired position, guide the system that syringe needle is pierced into desired position and injection is manipulated Device actuation means are injected the medicament or material of desired amount and enter patient.One of this invention for using is facilitated implementation in basis In embodiment, actuation means are included with lever actuator, and the lever actuator has neighbouring or radial separation in syringe cylinder Tip position or distal end one end and the other end is connected to actuation means.This can strengthen the singlehanded control of equipment.For example, pass Send the base section of system can be held between forefinger and thumb between the tiger's jaw (web space) of handss and user forefinger For depressing lever actuator.The end of the distal part or distal end of the neighbouring syringe cylinder of lever actuator can be exposed with pin Part be nonoverlapping relation so that pin is injected patient by without prejudice to.Additionally, bar can be pivotally mounted to device so that making User can be with single clenching of the hand bar, while gripping system to distribute material from allotter with the handss.Constructed using the bar, used Person can feel returning pressure and control the delivery rate of just allocated material.Made with one hand as the bar arrangement can strengthen With the ability of equipment, so which can lift the convenience for using.Additionally, singlehanded characteristic can be with strengthening system during use Stability.

Actuated syringes device may be additionally configured to reusable.For example, actuated syringes device can be configured to point Orchestration or syringe releasedly or are removedly installed or are connected to thereon so that for example replaced with new allotter or syringe Change used allotter or syringe.Additionally, actuation means can be configured to is connected to ready-made medical dispenser or syringe.

An embodiment of the invention, hand-held medicine or medical treatment physical distribution system include syringe (or allotter), which can have the cylinder of comprising medicine or medical treatment material, and the cylinder releasedly or is removedly installed Or it is connected to the base portion or framework of actuation means.Actuation means include the base portion for being slideably mounted to actuation means or framework Pusher (or slider) and can shift with activate or mobile pusher bar.Bar may be disposed to, and one end is positioned adjacent to note The end in the distally of emitter cylinder or end sections, the end in the distally of the syringe cylinder or end sections can be equipped with pin. For example, the system (can be positioned at the retainer of predetermined position, to limit dominant bit of the bar from original position including mechanism Move) so that when bar is shifted completely from original position, bar activates pusher (or slider) so that injection in syringe cylinder Device plunger moves specific range, and this is reproducible (for example, when bar is shifted from its original position again completely).Become at one In type, the specific distance that syringe plunger is advanced, which can be the same distance that pusher is advanced, and can be adjusted and adjust Distance can reproduce, for example, preset the maximum rod displacement of adjustment by using adjustable mechanism.For example, pusher and syringe The travel distance of plunger can be preset using adjustable retainer, and the retainer is carried from the maximum displacement of its original position to bar For adjustable restriction so that the material of default plunger distance and distribution can be changed.

Specific syringe plunger travel distance, which can be preset based on the position of such as bar retainer, can be changed Into volume that is known and remaining the reproducible material discharged from above-mentioned syringe or material, this can make user The material (for example, fluid or paralysis medicament) of desired, default or predetermined amount can repeatedly be delivered to such as patient's Face is treating facial line or wrinkle.The system can be also used for repeating the above-mentioned substance of delivering doses to treat facial stricture of vagina Or wrinkle.The dosage can also change.Generally speaking, bar, pusher and plunger are advanced amount or distance, mobile amount or displacement Can preset for example, by bar retainer, to distribute, deliver, spray or inject desired, default or predetermined amount, body The material of product, dose or dosage.For example, maximum rod displacement can be predetermined so that pusher and/or plunger movement are desired, pre- If or predetermined distance, to distribute the material of desired, default or predetermined amount from syringe.

Additionally, system may be configured such that its it is available it is singlehanded support, this can strengthen the steady of its system during use It is qualitative, and the arrangement of bar can strengthen the convenience that operator is used with the singlehanded ability using equipment and lifting.

With reference to Fig. 1 and Fig. 2, the illustrated examples of one embodiment of the invention are shown.Fig. 1 is hand-held medical thing The exploded view of matter distribution, delivering, ejection or injecting systems 100, the system include syringe 200 and actuated syringes and/or survey Determine device or equipment 300.Fig. 2 shows syringe 200, and the syringe 200 releasedly or is removedly coupled or mounted to Actuated syringes device 300.

Syringe 200, which can be any standard hypodermic, and the standard hypodermic has injecting fluid (example Such as, liquid or gas) enter the hypodermic needle 202 of bodily tissue, couple the cylinder or pipe 204 of pin thereon and in cylinder The plunger 208 of slidable movement in 204.

Fig. 1 is returned to, there is distal portions 204a and proximal part 204b, cylinder or pipe 204 to accommodate fluid for cylinder or pipe 204 (for example, any of suitable paralysis medicament or dermal filler for being used for treating facial line or wrinkle) simultaneously has at one end Hole is for dispensing liquid into pin 202 from hole.Plunger 208 is with the close-fitting piston head 210 in the cylinder 204 and can be pushed away Dynamic thumb actuator or handle 212 with from cylinder and pin distribution fluid.Cylinder can be provided with distal end taper tip 206, pin quilt Connection is refined on the distal end taper tip, and cylinder can be transparent so that the amount of fluid therein or material can be supervised Control.Syringe cylinder 204 can have the graduated labelling of mark or mark 214a, 214b, 214c, 214d, 214e, 214f ..., 214n is indicating the volume of fluid therein.In illustrated examples, two (for example, 214d of arbitrary neighborhood in these lines And 214e) between volume correspond to 0.1 milliliter.Labelling between these lines further indicates 0.05 milliliter of amount.It is any Suitable material (for example, plastics or glass) can be used to manufacture cylinder.

Although showing a syringe construction, any suitable syringe construction can be used and for this area is common Technical staff will be apparent.For example, without the syringe of pin, but pin can be installed to the syringe, for example, can use one The pin of secondary property.

Before syringe is installed to base portion, operator or doctor can perform air known in the art and remove journey Sequence, and syringe is tapped while keeping syringe to make pin upwards, then pushing syringe plunger is distributing some liquid. Alternatively, as will be described in more detail, operator or doctor can be moved from syringe using actuated syringes device 300 Except air.

Syringe 200 releasedly or is removedly coupled or mounted to actuated syringes or determines device or equipment 300. In illustrated examples, actuated syringes device 300 includes base portion or framework 302, and Syringe support 304 is attached to the base portion Or framework 302.Alternatively, framework and support member, which can be any suitable material, and such as plastics may be integrally formed For one-piece construction.As shown in Figure 7A, support member 304b has curved surface (for example, which can be spill or U-shaped surface), Syringe cylinder 204 is laid in the curved surface.The support member 304a being hidden in the view of Fig. 7 A has identical structure Make.Although showing a kind of curved surface formed in support member 304b, can be come using any other suitable surface Support syringe.

Syringe 200 can be fixed to actuated syringes device base portion 302 using any suitable method.In illustrated examples In, syringe cylinder 204 is fixed to support member 304a, 304b (for example, seeing Fig. 2 and Fig. 7 A) by belt 306a, 306b.Due to every Individual belt is fixed to respective support member in an identical manner, so in order to simplification is only described the fixation of belt 306b.Belt 306b has first end 306b1 for being fixedly secured to support member 304b (for example, along support side) and separably fixes To the second end 306b2 of support member 304b (for example, the another side of support member) so that belt extends across syringe cylinder simultaneously Closely keep the syringe cylinder to exclude or minimize the relative axle between syringe cylinder and support member against support member To motion.Any suitable separable fixed mechanism can be used for for the second end 306b2 being detachably secured to support member.Example Such as, loop fasteners can be used, which can be the loop fasteners of Velcro.RTM. brands.One can be provided along the side of belt Group hook fastener, one group of ring fastener for being provided with the part along support member are engaged.Alternatively, can be along the side of belt One group of hook fastener engagement that the part that one group of ring fastener is provided to engage along support member is provided.In a modification, band The two ends of son can be detachably secured to its respective support member.Although it is also understood that show two support members, Support member, two support members, plural support member or no support members can be used.For example, can shape in base portion 302 Into curved surface, or curved surface is not provided, syringe 200 is fixed to injection by fixed mechanism can still be used in this case Device actuation means 300.

Actuated syringes device 300 may also include actuator, and the actuator can make syringe plunger 208 towards syringe Pin 202 moves to distribute or inject the material of multiple desired volumes or predetermined volume.In illustrated examples, one is shown Individual such actuator, and the actuator includes pusher or pusher member 308, bar or lever arm 320 and connection pusher structure The driver or drive component of part 308 and lever arm 320.The desired volume of the material for changing to be allocated can also be included or made a reservation for Volume mechanism, as by described in below with reference to the exemplary shown by FIG.It will be appreciated, however, that Although a kind of actuator construction will be described, other can make the syringe plunger 208 in syringe cylinder 204 towards syringe needle 202 movements are constructed with the actuator for distributing or spraying the material of multiple desired volumes or predetermined volume, and other changes The desired volume of material to be allocated or being injected into patient or the mechanism of predetermined volume can also be used.

With reference to Fig. 1 and Fig. 7 A, base portion 302 has the vertical passage or groove 302a for being formed wherein, and pusher 308 can It is slidably mounted in the passage or groove so that as shown in drawings, when syringe is installed to base portion 302, pusher can be big Cause to move parallel to the plunger 208 of syringe 200.Groove 302a can extend the whole length of base portion 302, and can with The construction that the construction of pusher 308 is engaged so that ought orient during pusher 308 is maintained at groove and as shown in such as Fig. 7 A Shi Buhui is dropped out from base portion 302, for example as shown in Figure 7 A.In illustrated examples, groove 302a has the first of neighbouring its opening The part 302a1 and Part II 302a2 inwardly positioned from Part I, Part I have the first width, Part II tool There is the second width more than the first width.Pusher 308 has corresponding first width of neighbouring its tooth 310 and extends laterally shape Into the second width coordinated with the wider portion of groove 302a, as shown in Figure 7 A.Although it is shown that a kind of groove-pusher structure Make, but it is to be understood that pusher 308 can be maintained at into the groove being formed in base portion 302 using other constructions or mechanism In.For example, as will be described below, when ratchet shell 314 is fixed to base portion 302 and is fixed into and pusher ratchet 316 When tooth 310 is engaged, ratchet 316 can be maintained at pusher 308 in the groove being formed in base portion 302, push away in this case Dynamic device can have single width.However, groove construction can help to the assembling of device and avoid the need for ratchet to prop up as described above Support pusher.Shell 314 can also include that this is for this area around the single element for being mounted in mechanism's assembling therein Those of ordinary skill be obvious.It is also understood that shell 314 can be with other constructions in addition to shown circle. For example, shell 314 can be square or rectangle, and one side opening is being attached to base portion 302.

Pusher tooth 310 extends from the bottom of pusher 308 and along its length with the drive gear teeth with ratchet 316 318 are engaged so that ratchet 316 can be moved towards the plunger handle of syringe plunger 208 or plunger thumb actuator part 212 Dynamic or driving pusher 308, or when pusher as shown in Figure 3 308 and plug portion 212 make pusher 308 and post when engaging Plug portion 212 is moved with it.Pusher 308 is included in the upwardly extending part in the side contrary with pusher tooth 310 or prolongs Extending portion 309, and the part or extension 309 be arranged or be aligned to engage or extrude the plunger handle of syringe plunger 208 or Plunger thumb portion 212.In this way, when pusher 308 is moved towards the distal end or pin end of syringe 200, pusher Plunger in the propulsion of part 309 plunger cylinder 204.For example in the diagram, when system 100 is moved (such as direction towards patient's therapentic part Shown in arrow 102a) when, device 300 does not advance the state of plunger 208 in pusher 308.Then pin 202 exists as shown in Figure 5 Therapentic part be pierced into through patient skin " S ", rear bar 320 be fully depressed on the direction of arrow 322, make ratchet 316 Rotate up in the side of arrow 324, so that pusher 308 and plunger 208 are advanced with ratchet on the direction of arrow 326 (Fig. 5) Pharmaceutical substance injection is entered into patient.After injection, as with indicated by direction arrow 102b (Fig. 6), system 100 can be from Patient retracts or removes and do not move ratchet or plunger.This can repeat in one or more different parts, with each position To the desired amount of patient delivery or the material of predetermined amount.

Any suitable known ratchet assembly can be used to make driver a side as a part for driver Rotate up, such as the ratchet assembly with the ratchet combined with spring loads pawl, the ratchet have handle ratchet wheel tooth and external gear Tooth.

With reference to Fig. 7 A and Fig. 8 A-8B, for illustrative purposes, show in illustrative embodiment and use ratchet mechanism A kind of driver or drive component.In this example, lever arm 320 is connected to pusher 308 by driver or drive component. Shown driver or drive component include ratchet mechanism 312 (for example, seeing Fig. 8 A), and the ratchet mechanism generally includes ratchet 316 and pawl 342a, 342b, the ratchet 316 also serves as drive gear, and pawl 342a, 342b will be described in greater detail below.Letter For it, bar 320 rotate or activate ratchet 316 with towards the distal end of syringe 200 drive pusher 308.

Ratchet mechanism 312, which is accommodated in ratchet shell 314 (for example, seeing Fig. 8 A) with extending from the ratchet shell To the axle or pin 336 of lever arm 320 (Fig. 7 A), including ratchet 316, the ratchet 316 is with along in its annular inner surface extension Handle ratchet wheel tooth 317.Ratchet 316 also have external gear teeth 318, the external gear teeth be engaged with pusher tooth 310 with such as figure The side that arrow 326 shown in 8B is indicated drives up pusher 308, and forms circular gear by this way.Handle ratchet wheel Tooth 317 is engaged with ratchet pawl 342a, 342b, and ratchet pawl is pivotally coupled to pawl support member 340 or is supported on pawl support member On 340, pawl support member is fixedly secured to pin or axle 336, and pin or axle extend through the formation of the center in pawl support member 340 Hole.Pawl 342a, 342b by pin 344a, 344b (for example, seeing Fig. 8 A) be pivotally mounted to pawl support member or wheel 340, pin 344a, 344b is fixed to pawl support member 304 and carries out spring loads by spring so that pawl is biased towards internal tooth 317 or promoted, With allow ratchet 316 only a direction (arrow for example, seen in Fig. 8 B 324) on rotate.In illustrative embodiment, spiral shell Rotation spring 346a, 346b are placed in the recess in support member 340 and are arranged towards internal tooth 317 and bias or driving pawl.However, It should be understood that, it is possible to use other layout of spring or construction, other layout of spring or construction including no recess or use which Other layout of spring of the spring of its type or construction, this will be obvious for those of ordinary skill in the art.Additionally, as follows What face will be described in further detail, pawl 342a, 342b are made into including inclined-plane or wedge-like portion 343a, 343b to help pawl from spine Wheel release.In operation, when the bar 320 for being fixedly secured to pin or axle 336 is depressed, bar 320 is in Figure 5 with numeral 322 The side of instruction is moved upward so that dynamic drive component.That is, bar 320 rotates pin or axle 336, and pin or axle 336 are fixedly secured to Pawl support member 340 simultaneously rotates pawl support member 340, and pawl support member 340 rotates with it pawl 342a, 342b.As pawl 342a, 342b When moving with the pawl support member 340 of rotation, these pawls promote the hook tooth 317 engaged with them, and these pawls to be biased, with Ratchet 316 is made to rotate up in the side indicated by arrow 324 as seen in fig. 8b.When ratchet 316 rotates companion in this direction When coordinating with pusher tooth 310 with its tooth 318, ratchet is driven up or mobile pusher 308 in the side of arrow 326 so that Pusher extension or arm 309 is engageable and propulsion syringe plunger 208 is distributing liquid.When bar 320 is allowed to return to which During initial or resting position, for example, as shown in Figure 6 (for example, by release lever arm 320), can be helical spring lever arm The side that spring 334 is moved towards its resting position and indicated in arrow 327 (Fig. 6) is lifted up or mobile lever arm 320 arrives which Starting or resting position.In example shown in Fig. 1-7A, spring 334, which is towards its starting or resting position catch bar 320, one end 334a with the post 335 being fixed to from the extension of base portion 302 is fixed to the other end 334b of lever arm 320 with which.With This mode, when lever arm is not depressed, lever arm can be maintained at its starting or resting position by spring 335.Other mechanisms Can be used to promote lever arm 320 towards its starting or resting position, this should be obvious for a person skilled in the art.

As lever arm 320 returns to its starting or resting position, which passes through pin or axle 336 in the opposite direction supports pawl Part 340 rotates.When pawl support member 340 rotates in this opposite direction, pawl 342a, 342b are on continuous hook tooth 317 Slip over, in illustrated examples, hook tooth 317 is shown as with asymmetric construction, wherein the side of each tooth compared to Opposite side has steeper gradient.It will be appreciated, however, that can also be using other hook tooth constructions.Lever arm 320 can again by Activate to be pushed further into ratchet 316 and pusher 308, and repeat as schematically shown in Fig. 8 C as needed.

Although it is shown that a kind of drive or drive component it should be appreciated that many other drivings or drive component Can be used as, this will be apparent for the person of ordinary skill of the art, and illustrated examples are not intended limit The scope of the present invention processed.

With reference to Fig. 8 D, show the release of pawl 342a, 342b to reset pusher 308.It is as directed and as below in incited somebody to action It is more fully described, when pawl is moved radially inward, user can be by pusher to pusher, such as with arrow 360 substantially Upper instruction, so as to the side indicated in arrow 362 is rotated up the ratchet for discharging.By this way, user will can be promoted Device 308 be reset to desired position (for example, syringe 200 be removed after, return to its position shown in fig. 2, with Prepare device 300 and desired medicament or material is loaded for another syringe).

With regard to the connection of lever arm 320 to ratchet 316, lever end 320b is fixedly secured to axle using any suitable method 336 or axle 336 in the recess that formed, and sell or axle 336 is fixedly secured to pawl support member or wheel using any suitable method 340 (for example, seeing Fig. 7 A and Fig. 7 E).For example, lever arm 320 can be fixed to into pin or axle using glue, adhesive or weldment 336, and spline connection is provided between pin or axle 336 and pawl support member or wheel 340.Alternatively, all these connections can be used For example glue, adhesive or weldment are made.By this way, bias towards its static or initial position (for example, seeing Fig. 4) Lever arm 320 can be depressed, so that pin 336 and pawl support wheel 340 rotate, and Then it is released so that lever arm 320 is moved up in the side that arrow 327 (Fig. 6) is indicated and its shown in returning to is initial or static Fig. 4 and Fig. 6 (for example, is seen) in position.

Fig. 7 A are returned to, pin or axle 336 extend through the opening on side wall 314a, 314b of ratchet shell 314.Side wall 314a Bearing or bushing 338 can be provided with, in order to realize or strengthen the rotation wherein of pin or axle 336.Alternatively, can select to use In manufacture axle and the side wall of shell material in order to realize the desired rotation in the wall 314a of side of axle 336, and without bearing Or bushing.Promoting button 354, which will be discussed in greater detail below, and extends through side wall 314b and provides support member, sell or axle 336 can rotate in the support member.It is also possible to select material in order to realize desired rotation, this is for this area Should be obvious for those of ordinary skill.

With reference to Fig. 7 B, cut-out of the ratchet shell 314 with exposed sidewalls edge 315a, 315b so that sidewall edge Base portion 302 is fixedly secured to, as shown in Figure 7A.

As ratchet 316 is supported by pawl 342a, 342b, pawl 342a, 342b are arranged on pawl support member 340, pawl support member 340 are arranged on pin 336, and pin 336 is arranged in shell 314, and shell 314 is fixed to base portion 302, so ratchet 316 is supported Engage with pusher tooth 310 in shell 314.Alternatively, ratchet can be maintained at such as Fig. 7 A institutes using ratchet maintaining body The desired position for showing.In this arrangement, ratchet maintaining body 319 includes that disk 319a, disk 319a have exterior section 319a1, interior section 319a2 and cylindrical bosses 319b, exterior section 319a1 are fixedly secured to ratchet 316, interior section 319a2 is alignd with ratchet wheel 340 but is not attached to thereon so that allow shifting relative between interior section 319a2 and ratchet wheel 340 Dynamic, cylindrical bosses 319b are rotatably mounted to axle 336 and disk interior section 319a2 extends from wheel hub 319b.Interior section 319a2 is also rotatably mounted to axle 336, and axle 336 extends through the central opening of interior section 319a2.Interior section 319a2 Can be with recessed so that being spaced apart with ratchet wheel 340.Additionally, maintaining body 319 can be formed single integral member and can With including any suitable material, such as plastics.

As discussed above, lever arm 320 can be configured and/or be arranged to facilitate implementation the one hand use of system.In explanation Property embodiment in, lever arm 320 have distal end or free end 320a (Fig. 1-6), near-end 320b (Fig. 7 E) and part 321 (Fig. 1- 6), the part 321 can be used to push up, activate or depress lever arm 320 in the side of arrow 322 (for example, seeing Fig. 5).Part 321 Angle can be adjusted to be substantially parallel to syringe cylinder 204 or note when syringe is installed to actuated syringes device 300 The longitudinal axis of emitter pin 202 extend.The distal portions for being located adjacent to syringe pipe 204 of part 321, and which is retouched The construction stated can strengthen finger can presses lever 320 convenience.However, other constructions can be used as.Lever arm distal end or from It is arranged in moving beside cylinder 204 by end 320a.It is also adjacent to the distal portions of syringe cylinder 204 and with pin 202 In not overlapping relation, so as not to disturb placement of the pin in patient's body, such as shown in figures 4 and 5, in Fig. 4 and Fig. 5 Caused by Lever Arm is shown as in total travel and 202 one-tenth nonoverlapping relations of pin.As shown in fig. 7, bar free end 320a Or the distal free end part of bar 320 can be also radially separated from cylinder 204.

In the embodiment shown in Fig. 1-6, it is desired, default that a kind of mechanism is provided so that distribution system can be delivered Or the material of predetermined amount or volume.In one embodiment, mechanism is configured to limit lever arm 320 in 322 (example of arrow Such as, see Fig. 5) direction on movement or propulsion (or limiting maximum radian or the arc length which can be advanced).By this way, the limit Mechanism processed also limits the rotation of corresponding ratchet 316 and the translation of pusher 308.The limiting mechanism is arranged such that lever arm 320th, travel distance or position when lever arm 320 is fully depressed by or is activated from its initial position of ratchet 316 and/or pusher 308 Shifting can be preset by this way so that can distribute or spray multiple desired, default or predetermined bodies from syringe 200 Long-pending material.The maximum movement of lever arm 320 can be predetermined with driving pawl 316 and/or the default distance of pusher.In diagram In embodiment, there is provided (for example, retainer or limiting device be 328) for bar retainer or bar traveling limiting device.Retainer 328 With arm 330, arm 330 extends from ratchet shell 314 and rotates 90 degree or any suitable amount to extend into the road of lever arm 320 Footpath.Part II 330b of the arm 330 with the Part I 330a extended from shell 314 and the path for extending into lever arm 320 (for example, seeing Fig. 7 C).As bar 320 cannot be traveled beyond retainer, what retainer arranged or defined bar 320 is fully advanced position Put.In another embodiment, retainer can be formed with from base portion 302 structure for extending and extending below bar 320 Part.When retainer does not have adjustable stopper element, actuated syringes device 300 can be with syringe 200 or therewith Any syringe for using or allotter use known technology to be calibrated to positioning, and wherein retainer will be positioned or be preset to The material being ejected of desired, default or predetermined amount or volume is provided.

With reference to Fig. 1-6, the retainer arm 330 of retainer 328 can include selectable mechanism or component to change lever arm Range or ultimate range or radian that 320 maximum displacement or lever arm are advanced, it is allocated desired, default to change Or predetermined amount or volume.In illustrative embodiment, retainer arm 330 can be provided with optional screwed hole, optionally Stopper element or setting screw 332 be rotatably positioned in the optional screwed hole so that setting screw 332 can be raised or Reduce the scope so that the movement that lever arm 320 can be advanced is altered or modified.Setting screw has contact surface or part 332a, lever arm 320 contact the contact surface or part 332a when which is fully advanced, and now can be increased or decreased due to setting screw, contact Portion is adjustable so that can change desired, the default or predetermined amount of allocated material.Setting screw 332 can include any suitable means, be used to help rotation setting screw so which moves up or down, such as its lower end In groove or any other suitable mechanism, this will be obvious for those of ordinary skills.

Desired, default or predetermined distribution, the spraying or note that setting screw 332 can include labelling to indicate The amount penetrated or volume so that its can be positioned in desired position or it is default with provide desired, default or predetermined amount or The material of the distribution of volume.For example, labelling can allow user (for example, operator or doctor) adjustment setting 332 (stop of screw Component) so that the amount or volume of the material of distribution can be changed and (for example, spray 0.1 milliliter, 0.2 milliliter or 0.3 from syringe Milliliter).For example, these volumes may correspond to be allocated desired, the default or predetermined amount or volume of material.Syringe is caused Dynamic device 300 can be calibrated using known technology with syringe 200 or any syringe being used therewith or allotter, To create labelling and provide the result.For example, tag line " 1 ", " 2 " and " 3 " can be by calibrating actuation means 300 and syringe 200 are created so that when set screw be in certain level when after 320 complete displacement of lever arm from syringe spray 0.1 milliliter, 0.2 milliliter or 0.3 milliliter, and tag line is provided based on the result on setting screw.

Therefore, Fig. 2, Fig. 4 and Fig. 5 and is for example referred to, system 100 can be calibrated such that stopper element or setting screw 332 Position can be being predetermined as shown in Fig. 2 or Fig. 4 so that pusher make plunger move it is desired, default or predetermined Distance (pusher removable same distance so that the result to be provided) with when bar 320 from its original position (for example, such as institute in the diagram Show) (as shown in FIG. 5, its Caused by Lever Arm is contacted and is carried from syringe 200 when setting screw 332) to be depressed into fully depressed position For desired, default or predetermined ejection or 0.1 milliliter of material (for example, fluid).When setting screw 332 is in the position When, the bottom of tag line " 1 " is alignd or is flushed with the upper surface of stopper arms 300 (for example, seeing Fig. 4).With reference to Fig. 2, when based on school The accurate material (for example, fluid) for creating tag line " 2 " to provide 0.2 milliliter and stopper element or setting screw 332 be adjusted or Reduce causing the bottom of tag line " 2 " to align or flush with the upper surface of stopper arms 330, and lever arm 320 is from its original position When being depressed at its contact stopper element or setting screw 332, the material for distributing 0.2 milliliter from syringe 200 (for example, flows Body).Another tag line, such as tag line " 3 " (for example, seeing Fig. 2) can be arranged on above tag line 2 so that in its bottom When aliging or flush with the upper surface of stopper arms 330, when lever arm 320 by from its initial position depress to its contact stopper element or Distribute 0.3 milliliter of material (for example, fluid) during setting screw 332.

Lever arm 320 activates pusher 308 so that the specific distance of movement in syringe cylinder 204 of plunger 208, this is specific Distance be adjustable and can be predetermined based on the position of such as bar stopper element 332, preset the maximum displacement of lever arm 320 Ability can change into the material discharged from syringe as described above or known to material and be still reproducible volume, Which can enable a user to repeatedly deliver the material of desired, default or predetermined amount or volume (for example, such as paralysis medicament Fluid) arrive patient.For example, this can strengthen the uniform result or uniform in certain region of the acquisition of user or operator The ability of the desired medicament of ground delivering.

It is also noted that (1) the lever arm actuator for adopting either individually or in combination or (2) lever arm retainer or stopper element have Help the human engineering of held dispensing systems.

With regard to the release of pawl described above, shown with one that resets the pawl relieving mechanism of pusher 308 for release piece Example for example schematically shows in Fig. 7 D-7F and is generally represented with reference number 350.With reference to Fig. 7 D, relieving mechanism 350 is substantially It is upper to include promoting button 354, open cylinder 351 and biasing mechanism, promoting button move open cylinder 351 with pawl The pawl inclined-plane of 342a, 342b or wedge-like portion 343a, 343b are engaged, and biasing mechanism (such as helical spring 352) makes cylinder 351 bias away from pawl 342a, 342b.

Promoting button or actuator 354 are the hollow tubular elements with closed end 354a and opening 354b.Promote Button 354 is rotatable and is slidably mounted on axle 336 and with groove formed therein or window 356, and lever arm 320 prolongs The groove or window 356 is extended through, such as schematic representation in figure 7e, Fig. 7 E schematically illustrate the promotion of Fig. 7 D from opposite side Button and lever arm.The otch of the formation groove 356 in promoting button 354 has top edge 356a, lower limb 356b and lateral edges 356c、356d.Fig. 7 F diagrammatically illustrate the top edge 356a of the promoting button of Fig. 7 E and the cross section of lever arm and groove and under Edge 356b.The width " w " of groove 356 be sized so that lever arm 320 can advance when being depressed or discharge its intention or Desired distance or stroke.The length " I " of groove 356 be dimensioned with allow promoting button 354 around lever arm 320 operation and Slide so that promoting button can be promoted with release piece and allow to return to its position not activated.

Promoting button 354 also extends through the opening in the wall 314b of ratchet shell side on axle 336, for example institute in fig. 7d Show, wherein promoting button 354 engages helical spring 352 and can move back and forth in sidewall opening.Helical spring 352 is around axle Ring-shaped edge face at 336, and the opening of the adjacent pawl support member 340 in one end and the adjacent promoting button 354 of its other end.With This mode, helical spring 352 make promoting button 354 towards its initial position or unactuated position biasing or promote, for example, such as exist Shown in Fig. 7 D.As directed can be that the open cylinder 351 of hollow cylinder includes the cylindrical wall with opening 351a and annular wall portions 351b in its other end.Annular wall portions 351b have central opening, and promoting button 354 extends logical Cross the central opening (as represented with reference number 353) and regularly fixed.Annular wall portions 351b and promoting button 354 Between be fixedly connected and can be made by any suitable method (such as welding, adhesive or glue), such as welding, adhesive or Glue continuously applies or discontinuous with interval mode applying for 360 degree or less than 360 degree.Spring 352 promotes promoting button 354 Away from pawl support member 340, and by promoting button 354, spring 352 promotes annular wall portions 351b of cylinder 351 against outer Shell side wall 314b.In this way, operator can towards 340 promoting button 354 of pawl support member so that pawl is moved radially inward, and Then discharge promoting button 354 so which can return to the unactuated position shown in its Fig. 7 D, such as generally use reference arrow Indicated by 358.Pawl 342a, 342b are formed into including inclined-plane or wedge-like portion 343a, 343b, inclined-plane or wedge-like portion 343a, 343b form a part of pawl 342a, 342b.As schematically shown in fig. 7d, inclined-plane or wedge-like portion 343a, 343b has side inclined taper configurations radially inward so that when cylinder 351a engagement ramps or wedge-like portion, its Pawl 342a, 342b is made to move radially inward.The shape taper configurations in the slope of diagram or inclined side can extend inclined-plane or wedge The length of shape part 343a, 343b, the distal portions that the length can be for example along pawl are apart from the distal end of respective pawl or freedom End extends short distance, or extends close to distances at pivot pin or different from the distal end of pawl or free end.However, should manage Solution, inclined-plane or wedge-like portion 343a, 343b can with it is shown be differently adjusted angle, configuration and/or arrangement with cylinder Body 351 is engaged so that when cylinder 351 is promoted towards pawl support member 340 and abuts this inclined-plane or wedge-like portion, pawl 342a, 342b are moved radially inward, and this will be apparent to those skilled in the art.Other relieving mechanisms Can also be used.

With reference to Fig. 7 D, when user wants to reset pusher 308, user promotes promoting button 354 so as to face pawl The opening of the cylindrical member 351 of support member 340 is moved towards pawl 342a, 342b.As schematically shown in Fig. 8 D, work as circle When the opening engaging claw inclined-plane of cylindrical wall 351a or wedge-like portion 343a, 343b, which makes chamfered portion 343a, 343b or pawl 342a, 342b are promoted radially inward around the pivot pin of pawl.In the position, the position of the resettable pusher of user 308.Also It should be appreciated that other relieving mechanisms can be used.After pusher 308 is reseted, promoting button 354 can be released to allow Pawl is re-engaged ratchet 316.

Following example is proposed to illustrate a kind of operational approach of behaviour of the present invention, and is not limiting as the scope of the present invention. For example, method described below will be associated with treatment facial wrinkles or line and will be disclosed, but be not intended to be constrained to this controlling Treat.More specifically, example is related to the injection of liquid filler or paralysis medicament in facial line or wrinkle to benumb face below Selectivity muscle, to provide the reduction of line or wrinkle and smooth.The injection it is repeatable with treat other lines or wrinkle or Add more liquid filleies to treat line or wrinkle.

The syringe 200 of paralysis medicament described above is accommodated, actuated syringes as described above can be installed at which Air is therefrom removed in advance before device 300, or actuated syringes device 300 can be used to make syringe carry out use Preparation.In the later case, syringe 200 can be fixed to actuated syringes device 300 and device is held so that Injection needle 202 is upwardly extended.Then actuated syringes device 300 can by depresses lever arm 320 (for example, with forefinger) activated with The proximal part or thumb end part 212 of propulsion pusher part or pusher arm 309 and syringe plunger 208 contact (if The proximal part or thumb end part 212 of pusher part or pusher arm 309 and syringe plunger 208 is not engaged (figure 2)), and and then as shown in FIG. 3, further activate to advance in syringe cylinder 204 by further depression bar arm 320 Syringe plunger 208, so as to distribute the first small amounts of material (for example, the drop " d " of material), so that syringe carries out the standard for using It is standby.Fig. 3 shows that lever arm 320 is only partially depressed to distribute the material of a small amount of.

If device 300 is not applied to make syringe carry out the preparation for using (for example syringe is being fixed to injection, Before device actuation means 300, get out syringe) or pusher extension 309 without and syringe thumb actuator part 212 (Fig. 2) are engaged, then bar 302 is depressed so that pusher 308 is engaged with thumb actuator part 212 and and then release lever 302 To allow which to return its initial position as shown in FIG. 4 or remain static.

When hand held system 100 is ready to use, operator or doctor are with the system that is hold by one hand 100, system embedment quilt Support is in the tiger's jaw (web) between thumb and forefinger of the handss of doctor or operator and forefinger is in bar part 321, such as schemes Generally schematically show in 9.Middle finger can provide the further support for grip device 300.Operator or doctor make The skin of patient and stretched skin are kept to help correctly place syringe needle with another handss in facial line or crumple zone With delivering medicament.Then operator or doctor advance distributor 100 towards the target site on patient skin, such as in the diagram With indicated by arrow 102a.

With reference to Fig. 5, after operator or doctor have used syringe needle 202 to be pierced into patient skin, he or she presses completely Lower lever arm 320 engaging the setting screw or stopper element 332 of bar retainer 328 so that pusher 308 and syringe plunger 208 move desired (or default and/or predetermined) distance and inject desired (or default and/or predetermined) amount (or Volume, dose or dosage) paralysis medicament enter treated facial line or wrinkle under muscle in.

Fig. 6 shows Distributor 100 after initial position shown in Fig. 4.Then operator or doctor can stick a needle into another position To treat other lines or wrinkle, or increase more liquid filleies to the line or wrinkle for the treatment of, and this can be repeated Until syringe is emptying or wherein no longer accommodates desired (or default and/or predetermined) amount (or volume, dose or dosage) Material or paralysis medicament till.Then syringe 200 can be removed from actuated syringes device 300, and pusher 308 can be weighed If, and another receiving it is desired paralysis medicament syringe can be installed to device 300 with continual cure patient or treatment not Same patient.Additionally, after any injection, the stopper element or setting screw 332 of retainer 328 can be adjusted, with The desired amount (or volume, dose or dosage) of the medicament that perioperative any time point change or change will be injected or phase (or default and/or predetermined) amount (or volume, dose or dosage) hoped.

Figure 10 illustrates another modification of allocation unit 100, and the allocation unit is configured to the thing in delivery reservoirs Negative pressure is produced in cylinder or reservoir 204 before the content of matter.The modification of the diagram also show setting with internal mechanism Standby 100, for purposes of clarity without any outer cover or shell.However, can provide to the example devices for illustrating Any amount of covering, shell, ergonomic fit part etc..As noted below, some modifications of the equipment include Healthcare is allowed using the covering of one-handed performance equipment.And, feature in addition can be included in allocation unit, Can for example allow to report and submit the feedback transducer of the electric current by the pin on syringe or the electrode for being connected to pin and/or syringe Or other circuit arrangements.

As shown, allocation unit 100 includes being connected to the syringe 200 of equipment 100.In the example shown in the series of figures, note Emitter 200 is releasably attached to allocation unit 100 by one or more connections or fixed mechanism 304,306.In unit 100 In can use any number of fixed mechanism.Additionally, the modification of the replacement of allocation unit 100 can include being built in allocation unit It is interior or with allocation unit all-in-one-piece syringe.

The equipment 100 described in Fig. 10 includes actuator 230, and the actuator 230 is by respective first axle 234 and Two axles 238 be mechanically coupled to first gear 232 and second gear 236 (wherein in Fig. 10, second gear and the second axle position in Behind ways 240).The other modification of equipment 100 allows nursing staff to catch equipment using thumb and middle finger, while Actuator 320 is operated using forefinger.Therefore, shell (not shown) can be configured to contribute to this operation.Additionally, in equipment In 100 some modifications, actuator 230 extends (for example, the end of the cannula/needle 202 of ancillary equipment) towards distribution end.The structure Offer user forefinger is provided and middle finger catches main body or equipment and the ability with forefinger actuator lever 230.Obviously, it is other to grip Construction is in the range of the modification of the replacement of the equipment of the disclosure.However, when forefinger pressure is applied to bar 230 and contact point When 231 persons that are moved through Proximity operation catch radian or the path of unit, the stability (when tissue is injected) of equipment increases.

Figure 10 also show the plunger 208 of syringe 200, and the plunger 208 is coupled to plunger counterpart 242, and plunger is matched somebody with somebody Component 242 makes plunger 208 be connected to bar by gear train.Therefore, when gear drive component is activated, plunger counterpart 242 makes Plunger is moved, and gear drive component is started by actuator 230.As shown, plunger counterpart 242 can also include various keys With passage 242 allowing the smooth propulsion of plunger 208.

In this embodiment, gear train is shown as the gear train of rack-and-pinion, and the first rack pinion 250 makes post Plug 208 is being moved up and the second rack pinion 252 makes plunger 208 move up rearward forwards.

Figure 11 A and Figure 11 B show the corresponding front view and rearview of the equipment 100 in Figure 10.Bar 230 and guiding structure 240 (not shown) of part is hidden so that the drive mechanism of illustrated modification is better described in Figure 11 A and Figure 11 B, is wherein driven Motivation structure causes the movement of plunger when lever actuator 230 is moved.As seen in Figure 11 A, the first drive gear 232 connects Close the first rack pinion 250.First drive gear 232 is rotated in response to the rotation of first axle 232.Figure 11 B illustrate coupled To the opposite side of the first axle 232 of drive rod 244.The modification of diagram also includes the anti-driven gear for being fixed to anti-driven axle 236 238.Anti-driven axle 238 is moved when anti-driven pulley 254 rotates.

The modification of equipment allows to make plunger 208 move in a first direction using the single stroke of bar 230 and subsequently the Two sides move up.Generally, this way moving allows healthcare that pin is injected patient and subsequent activated apparatus 100, So that producing negative pressure in reservoir, the negative pressure causes blood or other fluids to be retrieved reservoir or window 203 into equipment 100. In some cases, these as discussed above, healthcare attempt to confirm that pin is placed on muscle or other tissues In and not in the blood vessel.If by the inspection stroke, nursing staff confirms that pin is placed with being expected to, nursing staff can continue to make With delivering stroke implement injection.A benefit for performing this bidirectional-movement in single stroke is to make 202 remains stationary of pin. The risk that pin cursorily may be moved is which reduced, the risk causes to inject the undesirable region for being delivered to body.

Figure 11 B show example, and the stroke of bar 230 may include one or more sections 110 and 112 to allow in this example 208 inverted orientation of plunger.It should be noted that the length of section 110 and 112 can be adjusted on request, and the segment length shown in this merely for Exemplary purpose.

Figure 12 A to Figure 12 E show the gear driving group of the mobile period in actuator 230 by the first trip segment 110 The example of part.Figure 12 A illustrate the static or initial position of bar 230.It should be noted that the element of bar and other systems 100 and/ Or drive component can be by the biasing of spring allowing gears/actuators/wait return initial position.As shown in Figure 12 B, bar The movement of 230 continuation in the direction 150 causes anti-driven bar 248 anti-driven pulley 254 is rotated on direction 152.It is anti-to drive Movable pulley 254 is coupled to anti-driven axle 238 (illustrating in Figure 11 A) and rotates anti-driven gear 236, causes plunger to couple Movement of the part 242 on direction 154 backward.In shown example, the rear portion 231 of bar 230 not yet engages main driving Bar 244.Once the rear portion 231 of bar 230 engages the rear portion 231 of main drive rod 244, main drive rod 244 and bar in side Move on 156.However, main drive shaft 234 can adopt one-way clutch so that movement of the main drive rod 244 on direction 156 The movement that master gear drives 232 is not produced.As plunger attachment 242 movement backward causes main rack pinion 250 backward It is mobile, what the clutch was a need for.

Figure 12 D illustrate the movement of the continuation of bar 230 and the rotation of anti-driven gear 236 and anti-driven axle 238, so that post Plug connector 242 is continued to move in backward directions 154.Figure 12 E illustrate the feelings that the movement 150 of bar 230 reaches second segment 112 Condition.As depicted in fig. 12f, the movement 150 of bar 230 causes the anti-drive of anti-driven bar 248 into second segment 112 in this condition Dynamic surface 246 departs from from anti-driven pulley 254.In the example shown in the series of figures, the groove 256 on anti-driven bar 248 allows anti-drive Movement of the dynamic surface 246 away from anti-driven pulley 254.However, any amount of construction is (such as cam/driven member design, curve Shape etc.) can be used for preventing the movement of anti-driven pulley 254.Figure 12 E are returned to, the movement of 230 section 112 of bar causes master The movement of continuation of the drive rod 244 on direction 156, causes first or the rotation in direction 162 of master gear 232, causes post Plug connector 242 master gear 232 engage the first rack pinion 240 when (as shown in Figure 11 A) propulsion.

Disengaging prevents the movement backward of plunger counterpart so that bar 230 causes the by the movement of the continuation of second segment 12 The movement of one gear 232 and first axle 234, this finally causes the movement forward of plunger counterpart and plunger to discharge positioned at reservoir Or the material in cylinder.Further it is provided that the position of bar 230 is for illustrative purposes only, and first paragraph 110 and second segment 120 Arc length based on the amount of negative pressure and the amount of fluid of delivering can be needed to be adjusted.Furthermore, it is possible to adjust tooth as needed Wheel compares desired displacement or movement to obtain plunger counterpart.

In said sequence, first paragraph 110 is corresponding to inspection and second segment corresponds to delivered substance.Obviously, if medical Nursing staff observes the presence (or any other negative situation) of blood, the releasable actuator 230 of nursing staff and permission System recovery is to the static or initial position (if nursing staff is just attempting injection mass and avoiding muscle) shown in Figure 12 A. Alternatively, injecting systems can be used for confirmation and deliver substances in blood vessel, in the case, can confirm pin quilt using the inspection It is placed within blood vessel.The disclosure includes the conversion for using of any amount of system, and this allows plunger in the two directions Move and minimize the movement of pin and/or the single stroke with actuator.

Figure 13 shows the bottom view of the modification that figure 10 illustrates.The view of the diagram shows optional locking feature 258, locking feature 258 has one or more surfaces 260, and one or more surfaces 260 can engage anti-driven bar 248 (in this example, 262) locking feature 258 engages one or more pins of anti-driven bar 248 to a part.In the example of the diagram In, locking feature 258 can be pushed on direction 158 and perform inspection feature to engage anti-driven bar 248 and depart from equipment.

Figure 14 A to Figure 14 C illustrate the propulsion that the movement of actuator 230 causes plunger counterpart 242.Showing shown in these Example is illustrated and is departing from equipment when feature 258 makes anti-driven bar 248 separate from anti-driven pulley 254.However, identical principle Apply and depart from anti-driven pulley 254 in the anti-driven arm 248 when actuator 230 is into second segment as above traveling 112 When.

Figure 14 A illustrate the equipment when bar 230 is in static or initial position and can be moved on direction 164 100.As shown in Figure 14 B, when bar 230 is moved by direction 164, a part for actuator engages lever arm 248 and makes lever arm Move on direction 156.As anti-driven pulley 236 does not cause reverse movement, master gear 232 move in direction 162 and Engage with the main rack pinion 252 of plunger counterpart 242 so that plunger counterpart 242 is moved on direction 160.As shown , this also causes plunger 208 to move.Figure 14 C show the actuator 230 in end of travel.Additionally, relative to equipment 100 Remainder, the position of actuator 230 can change as needed.Some modifications of the present invention 100 are included by one or more bullets The spring that spring 266 is provided resets feature, and when the power for being applied to bar 230 is removed, the spring resets feature allows mobile jib 230 to recover To the initial position shown in Figure 14 A.The spring resets feature also makes lever arm 248,244 return to its resting position.In diagram Example in, spring 266 causes movement of the actuator 230 on direction 166, and now cavity feature returns can anti-driven bar 248 Return and second spring (not shown) contributes to movement of the bar 244 on direction 168.

The present disclosure contemplates any number of of equipment shown in herein is altered or modified, when delivered substance, this is any The way moving that permission plunger is altered or modified of quantity.For example, Figure 15 A illustrate the design of replacement, and wherein actuator 230 makes Cylinder 204 is mobile on direction 170 to keep plunger 208 stable simultaneously, and the wherein relative movement produces negative pressure in cylinder 204 To perform audit function.Figure 15 A and Figure 15 B show an example of the construction for performing the relative movement, wherein actuator 230 Including the first groove 270 and the second groove 272, cylinder is advanced in initial first groove 270 of mobile period and the second groove 272 of bar 230 204 and subsequently propulsion plunger 208 keeps cylinder 204 stable simultaneously so that plunger advances to distribute syringe on direction 160 204 content.

Figure 16 shows another modification for the element being used together with injecting systems described herein, as shown , unit 100 can include selectively contributing to the singlehanded any kind of outer cover 280 for performing the equipment or outer Shell.For illustrative purposes, shell 280 is shown without top cover.Additionally, shell 280 is may include by intubation 202 And/or any of sensing can perform by any number of electrode 286,288 being arranged in intubation 202 or in intubation 202 Power supply, electric contact, internal memory or processor (as specified by with 282).Circuit 282 can use any conventional conductive member 284 It is connected to pin/electrode 284.

Figure 17 A illustrate the perspective view of another example of allocation unit 100, and the allocation unit has the shell of improvement 420, the shell 420 of the improvement lifts the singlehanded positioning and the ability for activating of user implementation unit 100.The example of the diagram is also Show the plunger 208 being positioned in shell 420, plunger 208 relative to syringe 200 cylinder 204 slidably.

Shell 420 includes any amount modification of drive mechanism and/or gear assembly (such as these described herein) In one, wherein drive mechanism and/or gear assembly includes actuator 320, and the actuator 320 makes as discussed herein drive The movement of motivation structure is advancing the plunger counterpart of the plunger 208 for being connected to unit (as shown in Figure 17 b).

As discussed below, the shell for illustrating in Figure 17 A is configured with multiple features, and the plurality of feature lifts medical treatment and nursing Personnel perform the ability of calibrated shot.

Figure 17 B illustrate the top view of the unit 100 of Figure 17 A.As shown, the gear assembly and syringe of unit can In the window 424 of shell 420.In the modification of diagram, window 424 is exposed along top loading surface 422, and this allows will Syringe 200 is loaded in gear assembly.In the modification of diagram, loading surface 422 and window 424 allows enough spaces to use In syringe 200 is positioned in shell 420 so that syringe and plunger can be coupled to the suitable part of mechanism.Institute In the modification for illustrating, the exposure drive component of window 424, it is allowed to which syringe is alignd with the longitudinal axis of shell 420 reeve shell, So that the distal end of the distal end adjacent housings of cylinder 204 and cannula/needle extend beyond the distal end of shell.Window 424 also allows to use The plunger of syringe is engaged on gear assembly by person with plunger counterpart.Although not shown, window can be by one or many Individual lid closure.

The bottom view of Figure 17 C diagram shells 420 with illustrated base base surface 426, when positioning on the outer surface when outside Shell 420 is in static and stable position.When syringe is combined by the window 424 loaded on surface 422 or with other sides When formula is connected to unit, the base surface 426 allows user to keep stablizing for shell.

Figure 17 D illustrate the side view of the shell 420 of Figure 17 A, and show the support side 430 of shell 420 and many The individual recess for contributing to one-handed performance equipment.For example, shell 420 includes at least one base portion recess 432, at least one base portion Recess 432 is located at base surface 426.As discussed below, base portion recess 432 allows the tiger's jaw of the handss of user recessed in the base portion It is embedded in portion.Base portion recess 432 can also include orientation force surface 434, and orientation force surface 434 is allowed in the direction of injection On (towards pin 202) applying power and therefore mitigate hold strength or need pin 202 is advanced into the power of destination organization.Do not having In the case of orientation force surface 434, user must increase compression stress on shell to drive pin by using the finger of person Into tissue.

Figure 17 D also show the support recess 436 positioned at stayed surface 430, wherein support recess 436 to accommodate user The thumb of handss.Figure 17 E illustrate the reverse angle view of equipment, show bar side face 228, and the bar side face is with prolonging from base portion 426 Reach the bar recess 438 of the distal end of main body 420.When user one-handed actuation bar 320, bar recess 438 allows the food of user Refer to or middle finger maintenance/control device, bar recess 438 additionally aids holding forefinger in relatively straight profile.Main body 420 can be with Including positioned at bar side face 428 and adjacent to the distally or guide recess 440 for loading surface 422.When the forefinger engagement of user is activated During device 320, distally/guide recess 438 allows the embedded to balance main body 420 of user middle finger.It is as shown below go out, support Recess 436 and base portion recess 432 allow main body 420 embedded at the tiger's jaw of the handss of user, while distal recess 440 is allowed User is maintained at the power in the bar side face 428 of main body 420.

Figure 18 A and Figure 18 B illustrate the one-handed performance how shell 420 of Figure 17 A-17E facilitates implementation injecting unit Example.As shown, user can be with the tiger's jaw 4 of the handss 2 of user positioning base portion recess 432, while recessed along supporting Portion 434 extends thumb 6.As noted above, base portion recess 26 also (does not show in Figure 18 A or Figure 18 B including distal force surface Go out).The handss (palm or region especially proximate to thumb heel) of user can be used for the applying power or remote on the direction of pin End power enters tissue to drive pin.The surface reduce user and apply the compression stress of increase to the side of shell to drive which forward Demand.Figure 18 B illustrate the bar side face 428 of shell 420, and the wherein middle finger 10 of user handss 2 engages distal recess 440, far Side pocket 440 is in bar side face and adjacent to loading surface 422.Distal recess 440 allow user using middle finger 10 with thumb phase To equipment side on apply stable power.As shown, forefinger 8 engages actuator 320 with activation equipment.Figure 18 B are also Illustrate that the base surface 426 of the either side in base portion recess 432 provides increased surface region with support housing for user, Either still remaining finger 12 is used at the rear portion of equipment by the distal portions in equipment.

As discussed above, shell 402 construction allow using be hold by one hand and use unit (for example, with similar to The mode for holding a pen, or thumb and the first two finger forward or far end party is upwardly-directed).Set to grip using this positioning It is standby can strengthening system controllability during use and stability.The one-handed performance of this external system allows its user (for example, to grasp Author or doctor) other things are done using his/her idle handss.For example, it is when using the systematic treating wrinkle, singlehanded Operation allows the handss of the free time of user to keep the skin of patient and in crumple zone stretched skin, and this contributes to using another handss The correct placement of delivering medicament.The construction of the shell for illustrating also provides the behaviour to desired position that surface orientation is used for lifting Vertical property and the syringe needle for being lifted enter the penetrance of tissue.

Figure 19 A to Figure 19 C illustrate the various views of another modification of shell 420, the wherein various labeling section of the shell Divide and be intended to by handss or the finger engagement of user.For example, Figure 19 A illustrate bar 320 and distal recess 440, such as with visually obvious Mode or the labelling experienced by tactile.Figure 19 B and 19C show an example, in this example 440 He of distal recess Support recess 436 labeled and/or identified.

Figure 20 illustrates the design of another correlation, and which can be used together with injecting systems described herein or can conduct The independent improvement of conventional injection equipment is used, the independent improvement gives nursing staff and determines tissue before injection The ability of type.As shown, sensing counterpart 380 may include the sleeve 382 at opening 383, and sleeve 382 receives business Upper obtainable syringe, counterpart, female Luer (luer) etc..Sleeve 382 can include conductive intubation 384 and/or Individual or multiple electrodes 386,388.Intubation 384 (and/or electrode) can be coupled to counterpart 390, and counterpart 390 is illustrated in and sets On standby 380 sleeve 382 (but may be located at), wherein the counterpart allows sensing to match somebody with somebody Component 380 and power supply/processor/user interface section/wait 394 to couple.Unit 394 can include any amount of user feedback Signal, such as audition, vision, image display etc..Once injecting in tissue, unit 394 can recognize that care-giver whether will Pin is put in skin, muscle, fat, blood vessel etc..As noted above, pin (can be wherein needed using ground connection with monopolar mode Electrode 396) or using double pole mode (any one in two of which electrode combines or be used alone two electrodes with pin) as A part for current path.

When nursing staff must deliver injection enters tissue (for example, blood vessel, skin, fat, the muscle etc.) for determining, pass Sense unit 380 can be used.Conductive pin 384 (and/or electrode) can by recognize any known pattern of this tissue come There is provided electric current to recognize the type of tissue.

Figure 21 is illustrated for injecting systems described herein or another with what any independent injecting systems were used together On the one hand.Figure 21 shows holding unit 400, and the holding unit has region 402 to receive any kind of can generally obtain The bottle 402 containing medicine.Holding unit 400 includes one or more ports 406, and one or more ports are used for inserting pin To fetch the material in the syringe of infusion appliance (not shown).Holding unit 400 is generally coupled to power supply (DC source or friendship Stream power supply), power supply allows holding unit 400 to keep medicine/material in desired temperature.Alternatively, holding unit 400 can include Can be used to be heated or cooled material 404 without any power supply 410 material (for example dry ice, freon, ice, cold water, Hot water etc.).

Therefore, holding unit 400 can include user interface 408, and user interface 408 provides listening for the temperature with regard to material Feel, vision and/or image information and such as extra information such as time, batch, drug type.Allocation unit 400 Wall, go-cart, desk etc. can be attached to.The modification of replacement includes that Portable desk type is constructed.

In one example, the allocation unit for illustrating in Figure 18 can be used to throw in BOTOX (Botox), western horse Or any similar material (Xeomin).Such material is generally from dry lipophilic state reconstruction.Once reconstruct, such material Effect reduces over time, and its temperature and time is proportional.The usual way of standard is included in the standard of 35 degree of Fahrenheit temperature At a temperature of store the BOTOX of reconstruct.Holding unit 400 can prevent into/out freezer/refrigerator of having to when dispensing.Replace Bottle can be maintained at desired temperature by Dai Di, holding unit 400, obtain material to perform so as to allow nursing staff to repeat Injection.

Holding unit 400 further additional benefit is that nursing staff can loading injector without grip bottle 404, because bottle is temporarily affixed in holding unit 400.

Any feature described in any one embodiment described herein can be with any other embodiment Any other combinations of features, regardless of whether be preferred.

Devices disclosed herein and changing and modifications for method will be apparent to those of ordinary skill in the art.Therefore, should Work as understanding, foregoing detailed description and appended diagram are, for the purpose being aware and understand, and to be not limiting as the present invention's Scope, the scope of the present invention are defined by the following claims.

Although according to above embodiments describes the method for the present invention and equipment, for people in the art For member, some modifications and/or addition to above-mentioned preferred embodiment will be apparent.It is intended that the scope of the present invention extension To all such modifications and/or addition, and the scope of the present invention is only by the claim restriction of the present invention.

Claims

1. a kind of allocation unit, for being used together with syringe, the syringe has cylinder and relative to the allocation unit In the cylinder slidably to distribute the plunger of the material in the cylinder, the medical distribution system includes：

Casing assembly, the casing assembly are configured to fix the cylinder of the plunger so that the distal end of the cylinder is adjacent The distal end of the nearly casing assembly；

Drive mechanism, the drive mechanism are connected to the casing assembly, and the drive mechanism includes the post for engaging the plunger Plug counterpart；

Actuator；And

Gear drive component, the gear drive component are connected between the plunger counterpart and the actuator, the tooth Wheel drive component is configured to respond to the movement of the actuator and moves, with produce the plunger counterpart relative to institute Movement in the backward directions of the distal end for stating shell and subsequently produce the plunger counterpart contrary with the backward directions Forward direction on movement, the mobile generation plunger of the wherein described actuator on a continuous direction described Movement in backward directions and the forward direction.

2. allocation unit according to claim 1, single stroke of the wherein described gear drive component in the actuator In the plunger counterpart is rearward moved up and is subsequently moved up described forwards described.

3. allocation unit according to claim 1, a part for wherein described gear drive component can depart from so that institute State plunger counterpart to be moved up described forwards in the single stroke of the actuator.

4. allocation unit according to claim 1, wherein described gear drive component include at least first gear structure and Second gear structure, the first gear structure are configured to produce shifting of the plunger counterpart in the backward directions Dynamic, the second gear structure is configured to produce movement of the plunger counterpart in the forward direction；And

The single stroke of wherein described actuator includes first paragraph and second segment, and wherein described actuator is in the first paragraph Movement causes the movement of the first gear structure, and movement of the actuator in the second segment causes second tooth The movement of wheel construction.

5. allocation unit according to claim 4, the mobile period institute wherein in the actuator in the second segment State gear drive component and depart from the first gear structure.

6. allocation unit according to claim 4, wherein described first gear structure include rack-and-pinion component.

7. allocation unit according to claim 4, wherein described second gear structure include rack-and-pinion component.

8. allocation unit according to claim 4, wherein described first gear structure are releasedly coupled by first axle To the actuator so that the actuator causes the first axle and institute through the first paragraph to the movement of the second segment State actuator and disengage connection.

9. allocation unit according to claim 4, wherein described second gear structure are departed from the actuator, Zhi Daosuo State till actuator moves through the first paragraph.

10. allocation unit according to claim 4, wherein described second gear structure are connected to the cause by the second axle Dynamic device.

11. allocation units according to claim 1, wherein described actuator are connected to first axle, and the first axle is relative It is rotatable in the casing assembly, a part for wherein described first axle is connected to the gear drive component.

12. allocation units according to claim 11, wherein described first axle are located at the nearside of the cylinder.

A kind of 13. allocation units, including：

Syringe, the syringe have cylinder and relative to the cylinder slidably to distribute the material in the cylinder Plunger；

Actuator；And

Gear drive component, the gear drive component are connected to the plunger counterpart and the actuator, and the gear drives Dynamic component is configured to respond to the movement of the actuator and moves, to produce the plunger counterpart relative to the shell Distal end backward directions on movement and subsequently produce movement in forward direction, wherein described plunger counterpart it is described to Mobile generation in rear direction and the forward direction is during the actuator is moved in a single direction.

A kind of 14. methods for material is injected into patient, methods described include：

Tissue site of the syringe in neighbouring patient is positioned, the syringe has the plunger that is connected to cylinder and from described The intubation that cylinder extends；

The intubation is advanced in the tissue site；

Drive mechanism of the actuation linkages to the syringe, wherein described drive mechanism are configured to make the plunger and the circle Cylinder in the actuating in the single direction of the actuator of the drive mechanism in a first direction and subsequently with the first direction It is moved relative to each other in contrary second direction.

15. methods according to claim 14, also including the Part I for departing from the drive mechanism, with the driving Plunger movement in said first direction is prevented during the single actuating of mechanism.

16. methods according to claim 14, also include the cause in the described single direction partially by the actuator Part II that is dynamic and engaging the drive mechanism so that the Part II of the drive mechanism makes the plunger and cylinder It is moved relative to each other in this second direction.

17. methods according to claim 14, the actuating in the described single direction of wherein described drive mechanism include first Section and second segment, when methods described is additionally included in the second segment of the actuating in the single direction or in the single direction The amount of the blood of the cylinder is observed before the second segment for activating.

18. methods according to claim 14, the actuating in the described single direction of wherein described drive mechanism include described The first paragraph of actuator is advanced and second segment is advanced.

19. methods according to claim 17, are additionally included in the actuator into during second segment traveling or in institute State the amount that actuator observes the blood of the cylinder into before second segment traveling.

20. methods according to claim 17, wherein syringe are divided during the second segment of the actuator is advanced The material with predetermined amount.

21. methods according to claim 19, also including adjusting the drive mechanism to adjust the described pre- of the material Fixed amount.

22. methods according to claim 14, also including the intubation is kept, activate the drive mechanism, so that described Plunger and cylinder are subsequently moved relative to each other in said first direction and in this second direction and do not move described inserting Pipe.

Into the method for the injection of patient, methods described includes a kind of 23. materials of implementing：

The tissue site located injection means of neighbouring patient, the injection device have reservoir and intubation, and the reservoir is carried can The plunger slided in the reservoir, the intubation extend from the cylinder；

The intubation is advanced in the tissue site；And

One-handed actuation bar increases the volume of the reservoir and subsequently causes the plunger reduction described to cause the plunger first The material is deliverrf into patient by the volume of reservoir.

A kind of 24. equipment for the injected delivery of material is entered in tissue regions, the equipment include：

Reservoir, the reservoir are configured to preserve the material；

Plunger, the plunger are connected to the reservoir so that the volume of the mobile change reservoir of the plunger；

Intubation, the intubation are fluidly coupled to the reservoir in far-end, and the intubation is configured to be pierced into the tissue regions In；

Actuator, the actuator are mechanically coupled to the plunger, and wherein described actuator is configured to from resting position move Delivery location is moved, wherein described actuator makes the plunger produce in a first direction from the movement of the part of the resting position Raw movement, and wherein described actuator makes the plunger exist towards the movement of the continuation in the same direction of the delivery location Movement is produced in second direction, and wherein described first direction and the second direction are contrary.

A kind of 25. allocation units, for being used together with syringe, the syringe has cylinder and post to the allocation unit Plug, the plunger are that, slidably to distribute the material in the cylinder, the medical treatment distributes system relative to the cylinder System includes：

Actuator, the actuator are configured to move on the stroke in single direction, and the stroke in the single direction includes One stroke section and the second trip segment；And

Gear drive component, the gear drive component are connected between the plunger counterpart and the actuator, the tooth Wheel drive component is configured to respond to the movement of the actuator and moves, to produce the plunger counterpart in the first row Movement during journey section on the first direction of the distal end relative to the shell and the plunger counterpart is subsequently produced in institute Movement during stating the second trip segment in second direction opposite to the first direction.

26. allocation units according to claim 25, wherein described a part of of gear drive component can depart from so that The plunger counterpart is moved up forwards described in the single stroke of the actuator.

27. allocation units according to claim 25, wherein described gear drive component include at least first gear structure With second gear structure, the first gear structure is configured to produce shifting of the plunger counterpart in the backward directions Dynamic, the second gear structure is configured to produce movement of the plunger counterpart in the forward direction；And

28. allocation units according to claim 27, the wherein mobile period in the actuator in the second segment The gear drive component departs from the first gear structure.

29. allocation units according to claim 27, wherein described first gear structure are releasedly joined by first axle Be connected to the actuator so that the actuator through the first paragraph to the movement of the second segment cause the first axle and The actuator disengages connection.

A kind of 30. allocation units, the allocation unit is for being used together with syringe, and the allocation unit is configured to permit Perhaps by user one-handed actuation to deliver injection, the syringe has cylinder and plunger, and the plunger is relative to the cylinder It is that, slidably with the material by intubation distribution in the cylinder, the allocation unit includes：

Shell, the shell have the drive mechanism being connected to thereon, and the drive mechanism includes actuator, and the actuator makes Gear assembly movement is advancing plunger counterpart；

The shell includes loading surface, base surface, bar side face and support side, wherein：

The load table face includes window, and wherein the window exposes the drive component, with allow by the syringe with The mode of the longitudinal axis alignment of the shell is injected in the shell so that the distal end of the cylinder is remote adjacent to the shell The end and intubation extends beyond the distal end of the shell, and the plunger of wherein described syringe and the plunger counterpart It is pieceable；

The base surface is configured to keep the shell in static position when being positioned on the surface of outside, and ought wear Cross and allow to keep the stability of the shell when window couples the syringe；

At least multiple recesses, which has curve form on the housing, and the plurality of recess includes base portion recess and supports recessed Portion, the base portion recess are located in the base surface, and the support recess is along the support side from the base portion recess Towards the remote extension of the shell；And

It is wherein described to support recess and the base portion recess to be oriented to allow the thumb of user and tiger's jaw to be embedded in accordingly, and The end of forefinger engages the actuator and when the forefinger moves the actuator towards the distal orientation.

31. allocation units according to claim 30, also include the finger at least one of the plurality of recess Show thing, to allow the identification of the recess.

32. allocation units according to claim 31, wherein described indicant include tactile or vision indicant.

33. allocation units according to claim 30, wherein described support recess include at least one orientation force surface, institute State the longitudinal axis that at least one orientation force surface extends substantially transversely to the shell so that when from patient insert or remove During the intubation, user can apply normal force to the orientation force surface.

34. allocation units according to claim 30, also including bar recess, the bar recess is along the bar side face from institute Base portion recess is stated towards the remote extension of the shell, wherein described bar recess allows the forefinger in the cause of the shell It is embedded on dynamic device side.

35. allocation units according to claim 34, also include the indicant on the bar recess, to allow to institute State the identification of bar recess.

36. allocation units according to claim 30, wherein described bar recess include at least one orientation force surface, described At least one orientation force surface extends substantially transversely to the longitudinal axis of the shell so that when from patient insert or remove institute When stating intubation, user can be pushed or pull on against the orientation force surface.

37. allocation units according to claim 30, also including recess is guided, the guide recess is positioned at the shell The actuator side and the neighbouring distal end, the wherein described end for guiding recess to allow other finger it is embedded, with Further stablize the shell during the movement actuator.

38. allocation units according to claim 37, are also included positioned at the indicant guided on recess, right to allow The identification for guiding recess.

39. allocation units according to claim 30, the lid being additionally included on the window of the loaded surfaces, wherein The lid is removably coupled to the shell.

40. allocation units according to claim 30, also including the actuation surfaces for being connected to the actuator.

41. allocation units according to claim 40, also include the indicant in the actuation surfaces, right to allow The identification of the actuation surfaces.

42. allocation units according to claim 30, wherein described drive component also include that being connected in the plunger coordinates Gear drive component between part and the actuator, the gear drive component are configured to respond to the movement of the actuator And move, to produce movement of the plunger counterpart on the first direction of the distal end relative to the shell and subsequently produce Movement of the plunger counterpart in second direction opposite to the first direction.

43. allocation units according to claim 30, wherein described drive component also include gear drive component, the tooth Wheel drive component is connected to the plunger counterpart and the actuator, and the gear drive component is configured to respond to the cause The movement of dynamic device and move, to produce movement of the plunger counterpart on the first direction of the distal end relative to the shell And subsequently produce movement of the plunger counterpart in second direction opposite to the first direction.

44. allocation units according to claim 30, single row of the wherein described gear drive component in the actuator The plunger counterpart is made to move in said first direction and subsequently move in this second direction in journey.

45. allocation units according to claim 30, a part for wherein described gear drive component can depart from so that The plunger counterpart is moved in the single stroke of the actuator in this second direction.

46. allocation units according to claim 30, wherein described gear drive component include at least first gear structure With second gear structure, the first gear structure is configured to produce plunger counterpart shifting in said first direction Dynamic, the second gear structure is configured to produce plunger counterpart movement in this second direction；And

47. allocation units according to claim 46, the wherein mobile period in the actuator in the second segment The gear drive component departs from the first gear structure.

48. allocation units according to claim 46, wherein described first gear structure include rack-and-pinion component.

49. allocation units according to claim 46, wherein described second gear structure include rack-and-pinion component.

50. allocation units according to claim 46, wherein described first gear structure are releasedly joined by first axle Be connected to the actuator so that the actuator through the first paragraph to the movement of the second segment cause the first axle and Actuator disengages connection.

51. allocation units according to claim 46, wherein described second gear structure are departed from the actuator, until Till the actuator moves through the first paragraph.

52. allocation units according to claim 46, wherein described second gear structure are connected to described by the second axle Actuator.

53. allocation units according to claim 30, wherein described actuator are connected to pivot, and the pivot is relative to institute It is rotatable to state casing assembly, and a part for wherein described axle is coupled to the gear drive component.

54. allocation units according to claim 53, wherein described pivot are located at the nearside of the cylinder.

A kind of 55. methods for material is injected into patient, methods described include：

Tissue site of the syringe adjacent to patient is positioned, the syringe is fixed on the shell with drive mechanism, institute Stating drive mechanism includes actuator, and the actuator makes gear assembly movement to advance the post of the plunger for being connected to the syringe Plug counterpart；

Wherein described shell includes loading surface, base surface, bar side face and supports side and at least multiple recesses, described many Individual recess has curve form on the housing, and the plurality of recess includes base portion recess and supports recess, and the base portion is recessed Portion is located in the base surface, and the support recess is along the support side from the base portion recess towards the remote of the shell End extends；And

With the singlehanded grasping shell so that the thumb of the handss and tiger's jaw are respectively embedded in the support recess and the base portion In recess, to allow the singlehanded propulsion syringe to enter patient, and allow the forefinger end engage the actuator and The distal orientation is retained towards when the forefinger moves the actuator with implement injection.