CN106511489A - Drug for treatment of rheumatism and preparation method thereof - Google Patents
Drug for treatment of rheumatism and preparation method thereof Download PDFInfo
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- CN106511489A CN106511489A CN201611137400.2A CN201611137400A CN106511489A CN 106511489 A CN106511489 A CN 106511489A CN 201611137400 A CN201611137400 A CN 201611137400A CN 106511489 A CN106511489 A CN 106511489A
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- radix angelicae
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Classifications
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a drug for treatment of rheumatism and a preparation method thereof, and the drug comprises notopterygium root, radix angelicae pubescentis, cassia twig, radix gentianae macrophyllae, radix angelicae sinensis, rhizoma ligustici wallichii, liquorice, kadsura pepper stem, Mulberry Twig, frankincense and Radix Aucklandiae in a certain weight ratio. The drug has the effects of dispelling wind and eliminating dampness, promoting menstruation, regulating qi, eliminating cold to stop pain, harmonizing blood, relaxing muscles and tendons, reducing fever and causing dieresis, is used for the treatment of rheumatism, is quick in effect and good in curative effect, and is non-recurrence.
Description
Technical field
The present invention relates to a kind of treat medicine of rheumatism and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Rheumatism is one group of infringement joint, skeleton, muscle, blood vessel and about the disease based on soft tissue or connective tissue,
Wherein most is autoimmune disease.The traditional Chinese medical science then thinks the damp and hot heresy institute obturation of rheumatism and wind and cold, causes that QI and blood is obstructed, meridians
Numbness resistance is relevant.Due to western medicine large side effects, therefore there is great demand to the Chinese medicine of effectively treatment rheumatism in people,
Up to now, it has not been found that with regard to the relevant report of the present invention.
The content of the invention
The present inventor have found effectively treatment rheumatism finally according to the research and the checking repeatedly of clinical trial of theory of Chinese medical science
Medicine, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine composition of effectively treatment rheumatism.
Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.
Medicine of the present invention be select Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentiss, Ramulus Cinnamomi, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Glycyrrhizae, Caulis Piperis Kadsurae, Ramulus Mori, Olibanum,
Radix Aucklandiae medicine is combined preparation, causes each efficacy of drugs to produce synergism these drug regimens such that it is able to effectively
Treatment rheumatism.Wherein it is because that its nature and flavor is worked hard from Rhizoma Et Radix Notopterygii, temperature enters bladder, kidney channel, has a scattered exterior cold, wind-damp dispelling, sharp joint
Function, cure cold wind and cold, lossless, anemofrigid-damp arthralgia of having a headache, stiffness of the nape muscular contracture, joint ache, edema due to wind pathogen edema, skin sore.From only
Work is because that its nature and flavor is worked hard, and temperature enters kidney, bladder warp, has wind-dispelling, wins wet, cold expelling, and the function of pain relieving controls anemofrigid-damp arthralgia, waist paint
Ache, trick spasm and pain, chronic tracheitiss, headache, toothache.Its property acrid-sweet flavor is because from Ramulus Cinnamomi, temperature enters bladder, the heart, lung
Jing, has sweating expelling pathogenic factors from muscles and skin, and the function of warming the meridian and promoting blood circulation controls exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea abdominal mass.From the Qin
Macrophylla is because its nature and flavor toil, puts down, and enter liver, stomach, gallbladder meridian have expelling wind and removing dampness, and blood relaxing muscles and tendons, the function of clearing away heat and promoting diuresis, dispelling the wind and dampness pathogens
Arthralgia pain, muscles and bones contracture, jaundice are had blood in stool, osteopyrexia and fever, children's infantile malnutrition with fever, dysuria.It is because that its nature and flavor is sweet pungent from Radix Angelicae Sinensis,
Temperature, enter the heart, liver, spleen channel have benefiting blood and regulating blood circulation, and menstruction regulating and pain relieving, the function of moisturize laxation control menoxenia, amenorrhea stomachache, abdominal mass knot
Poly-, metrorrhagia, headache due to deficiency of blood, dizziness, flaccidity syndrome and arthralgia syndrome, dryness of the intestine are difficult just, weight, ulcer sores, incised wound, injury from falling down after bloody dysentery.From Rhizoma Chuanxiong
It is because that its nature and flavor is pungent, temperature, enter liver, gallbladder meridian have activating QI to alleviate the depression, and dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain control air-cooled headache rotation
It is dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.It is because that its nature and flavor is sweet from Radix Glycyrrhizae
It is flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxify, the function of coordinating the actions of various ingredients in a prescription is processed with weakness of the spleen and stomach is controlled, and lack of appetite is suffered from abdominal pain
Carbuncle is shied in loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, solve poison of drug and
Alimentary toxicosis.It is because that its nature and flavor is worked hard from Caulis Piperis Kadsurae, tepor, enter the heart, kidney two warp have wind-damp dispelling, the meridian dredging, the work(of qi-regulating
Can, control anemofrigid-damp arthralgia, arthralgia, muscle arteries and veins contraction, traumatic injury, asthma, chronic cough.It is because that its nature and flavor is bitter from Ramulus Mori, puts down,
Enter Liver Channel, have wind-damp dispelling, anemofrigid-damp arthralgia, spasm of the limbs, beriberi edema, human body pruritus due to wind pathogen are controlled in sharp joint, the function of water-filling gas.Choosing
It is because that its nature and flavor is worked hard with Olibanum, temperature, enter the heart, liver, spleen channel have regulating qi and activating blood, and coagulation of QI-blood is controlled in analgesic therapy, the function of chasing after poison,
Trusted subordinate's pain, ulcerative carbuncle pyogenic infections, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.It is because that its nature and flavor is worked hard from the Radix Aucklandiae, temperature enters
Lung, liver, spleen channel, have promoting the circulation of QI to relieve pain, and the function of warming middle-JIAO for easing the stomach controls the invasion by pathogenic cold stagnation of QI, and chest and abdomen swelling and pain, vomiting are had loose bowels, after dysentery pain in the abdomen
Weight, colic of cold type.
Specific embodiment
The drug dose of instant component be also inventor through groping in a large number to summarize what is drawn, the consumption of each component is following heavy
All there is in the range of amount preferable curative effect：
10-20 gram of Rhizoma Et Radix Notopterygii, 10-20 gram of Radix Angelicae Pubescentiss, 5-15 gram of Ramulus Cinnamomi, 10-20 gram of Radix Gentianae Macrophyllae, 10-20 gram of Radix Angelicae Sinensis, 5-15 gram of Rhizoma Chuanxiong are sweet
Careless 5-10 gram, 45-55 gram of Caulis Piperis Kadsurae, 45-55 gram of Ramulus Mori, 3-7 gram of Olibanum, 5-15 gram of the Radix Aucklandiae.
Preferably：
15 grams of Rhizoma Et Radix Notopterygii, 15 grams of Radix Angelicae Pubescentiss, 10 grams of Ramulus Cinnamomi, 15 grams of Radix Gentianae Macrophyllae, 15 grams of Radix Angelicae Sinensis, 10 grams of Rhizoma Chuanxiong, 7 grams of Radix Glycyrrhizae, 50 grams of Caulis Piperis Kadsurae
, 50 grams of Ramulus Mori, 5 grams of Olibanum, 10 grams of the Radix Aucklandiae.
The preparation method of medicine of the present invention is as follows
First, get the raw materials ready
1st, Rhizoma Et Radix Notopterygii：Impurity is picked, is cleaned, is run through, cut into slices, dry；
2nd, Radix Angelicae Pubescentiss：Impurity is picked, separates size, cleaned, cut into slices after running through, be dried；
3rd, Ramulus Cinnamomi：Slightly soaked with water, pulled out, moistening is dried, weeds out bits to saturating, section；
4th, Radix Gentianae Macrophyllae：Impurity is picked, except removing LU, is slightly soaked, run through section, dry；
5th, Radix Angelicae Sinensis：Impurity is picked, is cleaned, moistening slightly dries in the air, and section is dried；
6th, Rhizoma Chuanxiong：Impurity is picked, is separated large and small, is soaked in water, solarization is dried in the air, cut into slices after moistening, be dried；
7th, Radix Glycyrrhizae：Pick impurity, clean, be soaked in water to eighty per cant it is saturating when, pull out, run through section, dry；
8th, Caulis Piperis Kadsurae：Active compound is soaked 30-60 minutes in putting clear water, and profit 16-24 hours in square-bottomed bamboo basket are put in taking-up, and section is dried；
9th, Ramulus Mori：Impurity is picked, is cleaned, is soaked in water, after running through, cutting is dried；
10th, Olibanum：Pick sand impurity；
11st, the Radix Aucklandiae：Crude drug in whole is put in clear water and is cleaned, pull out, moistening makes soft, section for 12 24 hours, dries.
2nd, prepare
1st, the Rhizoma Et Radix Notopterygii after processing, Radix Angelicae Pubescentiss, Ramulus Cinnamomi, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Glycyrrhizae, Caulis Piperis Kadsurae, Ramulus Mori, Olibanum, the Radix Aucklandiae are put into
In decocting container, add water for the first time 6 times and measure, after soaking 100 minutes, fry by intense fire to boil and rise, then with being cooked by slow fire 20 minutes, filter
First time decoction liquor is obtained, first time decoction liquor is poured in container；
2nd, the medicinal residues of filtration are added into 4 times of amounts, is boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；
3rd, will decoction liquor mixing and stirring twice, be divided into 2 doses and take.
In prescription, Caulis Piperis Kadsurae has a wind-damp dispelling, the meridian dredging, the function of qi-regulating, controls anemofrigid-damp arthralgia, arthralgia, muscle arteries and veins contraction
Function is monarch drug；Ramulus Mori expelling wind and removing dampness, sharp joint, water-filling gas；Radix Angelicae Pubescentiss have a wind-dispelling, win wet, cold expelling, the function of pain relieving, and the two is
Ministerial drug, three taste medicines play expelling wind and removing dampness jointly, qi-regulating of stimulating the menstrual flow, dispersing cold for relieving pain, control the effect of passages through which vital energy circulates contracture, and treatment rheumatism effect is complete
Face, and with expelling wind and removing dampness, qi-regulating of stimulating the menstrual flow can be effected a permanent cure based on dispersing cold for relieving pain；Radix Gentianae Macrophyllae has expelling wind and removing dampness, and blood relaxing muscles and tendons, clearing away heat and promoting diuresis
Function be adjuvant drug；Radix Glycyrrhizae has and middle emergency, lung moistening, removing toxic substances, and the function of coordinating the actions of various ingredients in a prescription, for making medicine, is to take stopgap measures with remaining all medicines.
Medicine of the present invention has expelling wind and removing dampness, qi-regulating of stimulating the menstrual flow, dispersing cold for relieving pain, and blood relaxing muscles and tendons, and the function of clearing away heat and promoting diuresis is used for
Treatment rheumatism, short treating period, instant effect, non-relapse after healing.
Specific embodiment：
The beneficial effect of medicine of the present invention is expanded on further below by way of test example, and these test examples include medicine of the present invention
The animal toxicity test report of thing and clinical observation on the therapeutic effect data.
The animal toxicity test report of [test example 1] medicine of the present invention：
Rabbit 30 is taken, male and female dual-purpose, 2.0 2.5kg of body weight are divided to two groups, 15 per group, one of which is tested for overdose
Group, another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is given for administration by gavage
Medicine, twice daily, serve on 7 days, the reaction of observation administration daily, as a result shows that two groups of rabbit activities, diet are normal, and medicine is without bad
Toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1st, physical data
Accept rheumatism out-patient totally 19 for medical treatment.
2nd, diagnostic criteria
Classical symptom is arthralgia, stiff, swelling, tenderness, joint deformity and dysfunction, the symptom such as weak fatigue.
3rd, Therapeutic Method
From above-mentioned medicament, take to patient, each take 1 dose, early daily, evening respectively takes 1 time, be within 10 days a course for the treatment of, continuously
Take 3 courses for the treatment of.
4th, efficacy assessment standard
It is effective：Rheumatism symptom disappears, and body constitution recovers normal, recovery from illness；
Take a turn for the better：Patient articular's pain, swelling are stiff, and the symptom mitigation such as tenderness, rheumatism symptom are clearly better, and body constitution is progressively recovered；
It is invalid：Improvement standard person is not reached.
5th, therapeutic outcome（See the table below）
In above-mentioned treatment, with Drug therapy rheumatic sufferers of the present invention 19, as a result effective 15, obvious effective rate is 78.95%, good
Turn 3, improvement rate is 15.79%, and invalid 1, total effective rate is 94.74%.
Claims (3)
1. a kind of medicine for treating rheumatism, it is characterised in that：It is made up of the crude drug in following weight range：
10-20 gram of Rhizoma Et Radix Notopterygii, 10-20 gram of Radix Angelicae Pubescentiss, 5-15 gram of Ramulus Cinnamomi, 10-20 gram of Radix Gentianae Macrophyllae, 10-20 gram of Radix Angelicae Sinensis, 5-15 gram of Rhizoma Chuanxiong are sweet
Careless 5-10 gram, 45-55 gram of Caulis Piperis Kadsurae, 45-55 gram of Ramulus Mori, 3-7 gram of Olibanum, 5-15 gram of the Radix Aucklandiae.
2. medicine according to claim 1, the consumption of wherein each crude drug is：
15 grams of Rhizoma Et Radix Notopterygii, 15 grams of Radix Angelicae Pubescentiss, 10 grams of Ramulus Cinnamomi, 15 grams of Radix Gentianae Macrophyllae, 15 grams of Radix Angelicae Sinensis, 10 grams of Rhizoma Chuanxiong, 7 grams of Radix Glycyrrhizae, 50 grams of Caulis Piperis Kadsurae
, 50 grams of Ramulus Mori, 5 grams of Olibanum, 10 grams of the Radix Aucklandiae.
3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：
（One）Get the raw materials ready
（1）Rhizoma Et Radix Notopterygii：Impurity is picked, is cleaned, is run through, cut into slices, dry；
（2）Radix Angelicae Pubescentiss：Impurity is picked, separates size, cleaned, cut into slices after running through, be dried；
（3）Ramulus Cinnamomi：Slightly soaked with water, pulled out, moistening is dried, weeds out bits to saturating, section；
（4）Radix Gentianae Macrophyllae：Impurity is picked, except removing LU, is slightly soaked, run through section, dry；
（5）Radix Angelicae Sinensis：Impurity is picked, is cleaned, moistening slightly dries in the air, and section is dried；
（6）Rhizoma Chuanxiong：Impurity is picked, is separated large and small, is soaked in water, solarization is dried in the air, cut into slices after moistening, be dried；
（7）Radix Glycyrrhizae：Pick impurity, clean, be soaked in water to eighty per cant it is saturating when, pull out, run through section, dry；
（8）Caulis Piperis Kadsurae：Active compound is soaked 30-60 minutes in putting clear water, and profit 16-24 hours in square-bottomed bamboo basket are put in taking-up, and section is dried；
（9）Ramulus Mori：Impurity is picked, is cleaned, is soaked in water, after running through, cutting is dried；
（10）Olibanum：Pick sand impurity；
（11）The Radix Aucklandiae：Crude drug in whole is put in clear water and is cleaned, pull out, moistening makes soft, section for 12 24 hours, dries；
（Two）Prepare
（1）Rhizoma Et Radix Notopterygii after processing, Radix Angelicae Pubescentiss, Ramulus Cinnamomi, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Glycyrrhizae, Caulis Piperis Kadsurae, Ramulus Mori, Olibanum, the Radix Aucklandiae are put into
In decocting container, add water 6 times and measure, after immersion 100 minutes, fry by intense fire to boil and rise, then with being cooked by slow fire 20 minutes, filter first
Secondary decoction liquor, first time decoction liquor is poured in container；
（2）The medicinal residues of filtration are added water 4 times and is measured, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；
（3）Decoction liquor mixing and stirring twice is incited somebody to action, is divided into 2 doses and is taken.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2022227333A1 (en) * | 2021-04-27 | 2022-11-03 | 广东省中医院 | Composition for preventing and/or treating rheumatoid arthritis, preparation method therefor, and application thereof |
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