CN106491832A - A kind of Chinese medicine composition and its preparation for treating stomach trouble - Google Patents
A kind of Chinese medicine composition and its preparation for treating stomach trouble Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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Abstract
The invention provides a kind of Chinese medicine composition for treating stomach trouble, the Chinese medicine composition includes that ratio of weight and number is 15～25:1 matrimony vine and Radix Glycyrrhizae.Present invention also offers the preparation that is made with the composition, the preparation is tablet or oral liquid.Can have a stomach upset, treat disease of stomach with relatively simple Chinese traditional medicine composition alleviation provided by the present invention for treating the composition of stomach trouble, the kind of raw materials used medicine is few, side effect is less, and the complementing each other of each Chinese medicine material medicine can be realized, cooperate with the purpose for playing curative effect, and lasting medicine, it is difficult to recur.After making tablet or oral liquid, take and carry convenient, and the curative effect of Chinese medicine composition can be given full play to；The interpolation of various auxiliary agents makes the compound traditional Chinese medicine composite property more stable, helps to maintain its therapeutic effect, and can provide good mouthfeel, takes convenient.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of composition and its preparation for treating stomach trouble.
Background technology
Stomach trouble is the general designation of multiple diseases related to stomach, and clinically common stomach trouble has acute gastritis, chronic gastritis, stomach
Ulcer, duodenal ulcer, gastroduodenal complex ulcer, polyp of stomach, gastric concretion, the also innocent and malignant tumour of stomach, stomach lining
Prolapsus disease, acute gastric dilatation, pyloric stenosis etc., these diseases have similar symptom, such as upper abdomen gastral cavilty portion discomfort, pain, meal
Glutted afterwards, belch, acid reflux, or even Nausea and vomiting etc..Occur multiple medicines for different stomach trouble on the market at present,
Wherein more with Western medicine.With rapid-action, evident in efficacy more than these Western medicine, it is suitable for alleviating acute disease, but
Due to relatively costly, and using rear easy generation side effect, therefore it is not suitable for Long-Time Service.
The big multicomponent of Chinese medicine of existing treatment stomach trouble is more at present, manufacturing procedure is complex, such as Authorization Notice No.
Patent of invention for CN102178887B discloses a kind of Chinese medicine of formula for treating gastropathy, including matrimony vine, Radix Glycyrrhizae, corydalis tuber, raw lacquer etc. 32
Taste Chinese medicine, wherein raw lacquer have certain toxicity, the symptom such as initiation allergic dermatitis easy to part population；Application publication number is
The application for a patent for invention of CN103463583A discloses a kind of Chinese herbal medicine for treating enterogastritis, including fructus alpiniae oxyphyllae, dandelion, sweet
The 21 taste Chinese medicine such as grass, reed rhizome, wherein reed rhizome are cold in nature, and deficiency-cold in spleen and stomach person should not take；Application publication number is CN105664114A's
Application for a patent for invention discloses one kind and treats the special digestant traditional Chinese herbal decoction of stomach trouble, including the malt, the membrane of a chicken's gizzard, root of Chinese trichosanthes, white
There is the effect of clearing heat-fire, deficiency-cold in spleen and stomach and phlegm wet person should not use for the 26 taste Chinese medicine such as art, wherein root of Chinese trichosanthes.Each Chinese medicine above
Although evident in efficacy, effect persistently, considers that user's physique is different, habits and customs are different, easily produce during use
Malaise symptoms, restricted application.Therefore, it is less while remaining to keep good drug effect that a kind of use Chinese medicine species is developed
Medicine, becomes the technical problem that those skilled in the art are badly in need of solving.
Content of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of composition and its preparation for treating stomach trouble.
Concrete technical scheme of the present invention is as follows：
One aspect of the present invention provides a kind of Chinese medicine composition for treating stomach trouble to be used in the medicine for treating stomach trouble in preparation
Application, the Chinese medicine composition include ratio of weight and number be 15～25:1 matrimony vine and Radix Glycyrrhizae.
Further, the ratio of weight and number of the matrimony vine and Radix Glycyrrhizae is 20:1.
Said components can play a part of to alleviate with simplest Chinese traditional medicine composition has a stomach upset, treats disease of stomach, while
It is not likely to produce side effect；There is good therapeutic effect using medicine of its treatment disease of stomach for preparing, and persistent,
It is difficult to recur.
Further, the Chinese medicine composition also includes the composition of following parts by weight：1～2 part of the bighead atractylodes rhizome, monkshood 0.5～
1.5 parts, 1.5～2.5 parts of Medicated Leaven, 1.5～2.5 parts of the Radix Astragali, 0.5～1.5 part of wrinkled giant hyssop, 0.5～1.5 part of the banksia rose and Rosa roxburghii 1
～2 parts.
Above-mentioned each ingredient combination is used, and with promotion digestion, pain-alleviating diarrhea-relieving, alleviates the functions such as raw, the maintenance taste of taste,
Auxiliary therapeutic action can be played, further enhance spleen and stomach function, improve therapeutic effect.
The present invention further provides a kind of Chinese medicine composition for treating stomach trouble, the Chinese medicine composition includes weight portion
Number is than being 15～25:1 matrimony vine and Radix Glycyrrhizae.
In order to easy to use, the invention provides the Chinese medicine preparation for the treatment of stomach trouble, including aforesaid Chinese medicine composition, described
Preparation is selected from tablet, capsule, pill, oral solutions or granule.
Another aspect of the present invention provides a kind of tablet for treating stomach trouble, and the tablet includes the Chinese medicine composition
1～2 part and 5～8 parts of auxiliary material, the auxiliary material includes the composition of following parts by weight：2.5～4 parts of filler, disintegrant 1～2
0.9～1.2 part of part, 0.6～0.8 part of adhesive and lubricant.
Further, the filler includes the composition of following parts by weight：1.5～2 parts of microcrystalline cellulose, D-sorbite
0.5～1 part and 0.5～1 part of poloxamer.
Microcrystalline cellulose, D-sorbite and poloxamer are used in combination as filler, the tensile strength of tablet and
Formability is considerably better than effect when one of which or two kinds are used alone.
Further, the disintegrant includes the composition of following parts by weight：0.5～1 part of sodium bentonite, colloidal state dioxy
0.25～0.5 part of 0.25～0.5 part of SiClx and gellan gum.
Sodium bentonite, colloidal silica and gellan gum are used in combination as disintegrant, piece can be significantly improved
The disintegration efficiency of agent, reduction disintegration time limited, greatly shorten the onset time of active ingredient.
Further, described adhesive includes the composition of following parts by weight：0.3～0.5 part of sodium alginate, peach gum 0.1
～0.15 part and 0.1～0.15 part of Carbomer.
Sodium alginate, peach gum and Carbomer are used in combination as binding agent, are obviously improved can adhesive effect, and
And the mouthfeel of tablet finished product can be improved, it is allowed to be easier to take.
Further, lubricant includes the composition of following parts by weight：0.5～1 part of sodium carboxymethylcellulose, laruyl alcohol sulphur
0.25～0.5 part of 0.25～0.5 part of sour magnesium and Compritol 888 ATO.
Sodium carboxymethylcellulose, magnesium laurylsulfate and Compritol 888 ATO are used in combination as lubricant, which moistens
Slip can be significantly improved, and can be obviously improved the efficiency of pelletizing press sheet process, improve tablet hardness.
The invention has the beneficial effects as follows：Can be with relatively simple Chinese medicine provided by the present invention for treating the composition of stomach trouble
Combination alleviation is had a stomach upset, treats disease of stomach, with promotion digestion, pain-alleviating diarrhea-relieving, alleviates the work(such as raw, the maintenance taste of taste
Can, the kind of raw materials used medicine is few, and side effect is less, and can realize complementing each other, cooperateing with performance to treat for each Chinese medicine material medicine
The purpose of effect, can reach the purpose of strong taste by reducing gastric acid secretion, enhancing gastroenteritic power, promotion digestion etc., so as to
There is to various stomach good therapeutic effect, and lasting medicine, be difficult to recur.After making tablet, take and carry more
Convenient, and the curative effect of Chinese medicine composition can be given full play to；The interpolation of various auxiliary agents makes the compound traditional Chinese medicine composite property
More stable, its therapeutic effect is helped to maintain, and good mouthfeel can be provided, taken convenient.
Specific embodiment
Embodiment 1
A kind of Chinese medicine composition for treating stomach trouble, including the composition of following parts by weight：1 part of 15 parts of matrimony vine and Radix Glycyrrhizae.
Embodiment 2
A kind of Chinese medicine composition for treating stomach trouble, including the composition of following parts by weight：1 part of 25 parts of matrimony vine and Radix Glycyrrhizae.
Embodiment 3
A kind of Chinese medicine composition for treating stomach trouble, including the composition of following parts by weight：1 part of 20 parts of matrimony vine and Radix Glycyrrhizae.
Embodiment 4
A kind of Chinese medicine composition for treating stomach trouble, including the composition of following parts by weight：15 parts of matrimony vine, 1 part of Radix Glycyrrhizae, the bighead atractylodes rhizome
1 part of 1 part, 0.5 part of monkshood, 1.5 parts of Medicated Leaven, 1.5 parts of the Radix Astragali, 0.5 part of wrinkled giant hyssop, 0.5 part of the banksia rose and Rosa roxburghii.
Embodiment 5
A kind of Chinese medicine composition for treating stomach trouble, including the composition of following parts by weight：25 parts of matrimony vine, 1 part of Radix Glycyrrhizae, the bighead atractylodes rhizome
1.5 parts of 1.5 parts, 1 part of monkshood, 2 parts of Medicated Leaven, 2 parts of the Radix Astragali, 2 parts of wrinkled giant hyssop, 1 part of the banksia rose and Rosa roxburghii.
Embodiment 6
A kind of Chinese medicine composition for treating stomach trouble, including the composition of following parts by weight：20 parts of matrimony vine, 1 part of Radix Glycyrrhizae, the bighead atractylodes rhizome
2 parts of 2 parts, 1.5 parts of monkshood, 2.5 parts of Medicated Leaven, 2.5 parts of the Radix Astragali, 1.5 parts of wrinkled giant hyssop, 1.5 parts of the banksia rose and Rosa roxburghii.
Embodiment 7
A kind of tablet for treating stomach trouble, including the composition of following parts by weight：1 part of Chinese medicine composition described in embodiment 1,
0.9 part of 2.5 parts of filler, 1 part of disintegrant, 0.6 part of adhesive and lubricant；The filler includes microcrystalline cellulose 1.5
0.5 part of part, 0.5 part of D-sorbite and poloxamer；The disintegrant includes 0.5 part of sodium bentonite, colloidal silica
0.25 part and 0.25 part of gellan gum；Described adhesive includes 0.1 part of 0.3 part of sodium alginate, 0.1 part of peach gum and Carbomer；
The lubricant includes 0.2 part of 0.5 part of sodium carboxymethylcellulose, 0.2 part of magnesium laurylsulfate and Compritol 888 ATO.
Embodiment 8
A kind of tablet for treating stomach trouble, including the composition of following parts by weight：1 part of Chinese medicine composition described in embodiment 2,
1 part of 3 parts of filler, 1.5 parts of disintegrant, 0.7 part of adhesive and lubricant；The filler include 1.5 parts of microcrystalline cellulose,
0.5 part of 1 part of D-sorbite and poloxamer；The disintegrant includes 0.75 part of sodium bentonite, 0.4 part of colloidal silica
And 0.35 part of gellan gum；Described adhesive includes 0.15 part of 0.4 part of sodium alginate, 0.15 part of peach gum and Carbomer；Described
Lubricant includes 0.25 part of 0.5 part of sodium carboxymethylcellulose, 0.25 part of magnesium laurylsulfate and Compritol 888 ATO.
Embodiment 9
A kind of tablet for treating stomach trouble, including the composition of following parts by weight：2 parts of Chinese medicine composition described in embodiment 3,
1.2 parts of 4 parts of filler, 2 parts of disintegrant, 0.8 part of adhesive and lubricant；The filler includes 2 parts of microcrystalline cellulose, mountain
1 part of 1 part of pears sugar alcohol and poloxamer；The disintegrant includes 1 part of sodium bentonite, 0.5 part of colloidal silica and knot
0.5 part of cold glue；Described adhesive includes 0.15 part of 0.5 part of sodium alginate, 0.15 part of peach gum and Carbomer；The lubricant bag
Include 0.3 part of 0.6 part of sodium carboxymethylcellulose, 0.3 part of magnesium laurylsulfate and Compritol 888 ATO.
Embodiment 10
A kind of tablet for treating stomach trouble, including the composition of following parts by weight：1 part of Chinese medicine composition described in embodiment 4,
0.9 part of 2.5 parts of filler, 1 part of disintegrant, 0.6 part of adhesive and lubricant；The filler includes microcrystalline cellulose 1.5
0.5 part of part, 0.5 part of D-sorbite and poloxamer；The disintegrant includes 0.5 part of sodium bentonite, colloidal silica
0.25 part and 0.25 part of gellan gum；Described adhesive includes 0.1 part of 0.3 part of sodium alginate, 0.1 part of peach gum and Carbomer；
The lubricant includes 0.2 part of 0.5 part of sodium carboxymethylcellulose, 0.2 part of magnesium laurylsulfate and Compritol 888 ATO.
Embodiment 11
A kind of tablet for treating stomach trouble, including the composition of following parts by weight：2 parts of Chinese medicine composition described in embodiment 5,
1 part of 3 parts of filler, 1.5 parts of disintegrant, 0.7 part of adhesive and lubricant；The filler include 1.5 parts of microcrystalline cellulose,
0.5 part of 1 part of D-sorbite and poloxamer；The disintegrant includes 0.75 part of sodium bentonite, 0.4 part of colloidal silica
And 0.35 part of gellan gum；Described adhesive includes 0.15 part of 0.4 part of sodium alginate, 0.15 part of peach gum and Carbomer；Described
Lubricant includes 0.25 part of 0.5 part of sodium carboxymethylcellulose, 0.25 part of magnesium laurylsulfate and Compritol 888 ATO.
Embodiment 12
A kind of tablet for treating stomach trouble, including the composition of following parts by weight：2 parts of Chinese medicine composition described in embodiment 6,
1.2 parts of 4 parts of filler, 2 parts of disintegrant, 0.8 part of adhesive and lubricant；The filler includes 2 parts of microcrystalline cellulose, mountain
1 part of 1 part of pears sugar alcohol and poloxamer；The disintegrant includes 1 part of sodium bentonite, 0.5 part of colloidal silica and knot
0.5 part of cold glue；Described adhesive includes 0.15 part of 0.5 part of sodium alginate, 0.15 part of peach gum and Carbomer；The lubricant bag
Include 0.3 part of 0.6 part of sodium carboxymethylcellulose, 0.3 part of magnesium laurylsulfate and Compritol 888 ATO.
Reference examples 1
Authorization Notice No. is the Chinese medicine composition disclosed in the patent of invention of CN102178887B.
Reference examples 2
Application publication number is the Chinese medicine composition disclosed in the application for a patent for invention of CN103463583A.
Reference examples 3
Application publication number is the Chinese medicine composition disclosed in the application for a patent for invention of CN105664114A.
Reference examples 4
A kind of tablet for treating stomach trouble, including the composition of following parts by weight：2 parts of Chinese medicine composition described in embodiment 3,
1.2 parts of 4 parts of filler, 2 parts of disintegrant, 0.8 part of adhesive and lubricant；The filler include 2 parts of D-sorbite and
2 parts of poloxamer；The disintegrant includes 1 part of 1 part of colloidal silica and gellan gum；Described adhesive includes peach gum 0.4
0.4 part of part and Carbomer；The lubricant includes 0.6 part of 0.6 part of magnesium laurylsulfate and Compritol 888 ATO.
Reference examples 5
A kind of tablet for treating stomach trouble, including the composition of following parts by weight：2 parts of Chinese medicine composition described in embodiment 3,
1.2 parts of 4 parts of filler, 2 parts of disintegrant, 0.8 part of adhesive and lubricant；The filler include 2 parts of microcrystalline cellulose with
And 2 parts of poloxamer；The disintegrant includes 1 part of 1 part of sodium bentonite and gellan gum；Described adhesive includes sodium alginate
0.5 part and 0.3 part of Carbomer；The lubricant includes 0.6 part of 0.6 part of sodium carboxymethylcellulose and Compritol 888 ATO.
Reference examples 6
A kind of tablet for treating stomach trouble, including the composition of following parts by weight：2 parts of Chinese medicine composition described in embodiment 3,
1.2 parts of 4 parts of filler, 2 parts of disintegrant, 0.8 part of adhesive and lubricant；The filler include 2 parts of microcrystalline cellulose with
And 2 parts of D-sorbite；The disintegrant includes 1 part of 1 part of sodium bentonite and colloidal silica；Described adhesive includes sea
0.3 part of 0.5 part of mosanom and peach gum；The lubricant includes 0.6 part of sodium carboxymethylcellulose and magnesium laurylsulfate 0.3
Part.
Experimental example 1
Anti-tensile effect comparative experiments
With in embodiment 7～12 provide treatment stomach trouble tablet as experimental group 1～6, with reference examples 4～6 offer
The tablet for the treatment of stomach trouble is control group 1～3.The radial direction destructive power of each set product is measured with analyzer using tablet four,
And tensile strength is calculated with formula T=2F/ π DL, wherein T represents tensile strength (MPa), and F is radial direction destructive power (kgf), and D is system
Obtain the diameter (cm) of tablet, thickness (cm) of the L for tablet.According to the compression molding that the size of tensile strength evaluates different fillers
Property.
The measurement result of 1 each group sample tensile strength of table
The tensile strength of tablet is typically between 1.5～3MPa, and the bigger expression compressibility of tensile strength is better.
As shown in Table 1, the tensile strength of each group reaches standard, and the tensile strength of experimental group each group is all remarkably higher than control group.
As a result show that these fillers are respectively provided with preferable anti-tensile effect, the wherein filling of microcrystalline cellulose+D-sorbite+poloxamer
Plus the lubricant combination of sodium carboxymethylcellulose+magnesium laurylsulfate+Compritol 888 ATO, to give tablet good for agent combination
Tensile strength and compact property, its effect is significant is better than only using wherein several fillers and effect during lubricant individually
Really.
Experimental example 2
Disintegration effect comparative experiments
The tablet of the treatment stomach trouble provided using in experimental example 7～12 as experimental group 1～6, with offer in reference examples 4～6
Treatment stomach trouble tablet as a control group 1～4, the disintegration time limited of each group sample is measured with hanging basket method, concrete grammar
As follows：Take each group tablet each 6, be respectively placed in the glass tube of hanging basket, often manage respectively plus a piece of, starting instrument makes hanging basket immerse 37
In ± 1.0 DEG C of water, move back and forth by the frequency of 30-32 time/min and the amplitude of 55 ± 2mm, from the beginning of being placed in glass tube from tablet
Timing, to tablet is broken and all solids particle all passes through the screen cloth of glass bottom of the tube, the time is collapsing for the tablet
The solution time；Undesirable if any 1, should separately take 6 retrials.With disintegration time limited as index, the disintegration effect of disintegrant is entered
Row is evaluated.
The disintegration time limited of 2 each group sample of table
2005 editions《Chinese Pharmacopoeia》Regulation, conventional tablet should be disintegrated in 15min completely.As shown in Table 2, experimental group each group
Disintegration time limited within the regulation time limit, and the disintegration time limited of experimental group each group, significantly less than control group each group, this shows
The disintegrant combination of sodium bentonite+colloidal silica+gellan gum has good disintegrating property, can greatly improve tablet
Disintegration efficiency, and sodium alginate+Carbomer+peach gum adhesive combination can provide suitable bonding effect, prevent because glue
Mixture improper use causes prolonged disintegration, and its effect is significant is better than wherein several disintegrants and during adhesive individually are used alone
Disintegrating property.
Experimental example 3
Clinical trial
1. case is tested
Patient with disease of stomach such as gastritis, gastric ulcer of 180 ages between 20～60 years old is chosen, is randomly divided into
9 groups, per group of 20 people, without the gestational period or nursing period patient in all patients, also without tumor patient.
2. dosage
The composition provided with embodiment 1～6, as experimental group 1～6, is right with the composition provided in reference examples 1～3
According to group 1～3,12 groups of patients are allowed to take above each set product respectively, 3 times a day, each 3g, bfore meals, continuous treatment 30 days,
The medicine of other treatment stomach trouble is not used during treatment.
3. evaluation index
Clinical manifestation：Upper abdomen gastral cavilty portion is uncomfortable, pain, glutted after meal, belch, acid reflux, Nausea and vomiting, and spitting blood, excrement are in
Black or bronzing.
Significantly effectively：After treatment, state of an illness sign is obviously improved, and malaise symptoms disappear substantially, and stool colour recovers normal；
Effectively：After treatment, state of an illness sign makes moderate progress, and malaise symptoms are eased, and vomiting, spitting blood number of times are significantly reduced, excrement
Just lighter；
Invalid：Without substantially change before and after treatment.
4. data processing
Finishing analysis are carried out to patient clinical data, the therapeutic effect of experimental group and control group is compared by t inspections
Compared with.
5. experimental result
3 each group patient's treatment of table
Experimental group and control group significant difference (p<0.05).
6. analyze and conclusion
As shown in Table 3, the efficient of experimental group is not less than 85%, and control group each group is efficient less than 80%,
Show that the curative effect of experimental group is better than control group；The efficient of experimental group 4～6 is generally higher than experimental group 1～3, shows components I+group
Divide II than single components I better efficacy；Experimental group 3 efficient higher than experimental group 1 and 2, while the efficient height of experimental group 6
In experimental group 4 and 5, illustrate that when the mass fraction ratio of matrimony vine and Radix Glycyrrhizae be 20:When 1, said composition to the therapeutic effect of stomach trouble most
Good.And over the course for the treatment of, there is allergic dermatitis, stomach weakness and the bad reaction such as increase in control group some patientss, and real
Test all patients of group and bad reaction do not occur during treating, show composition provided in an embodiment of the present invention to multiple common
Stomach trouble has a good therapeutic effect, and effect persistently, have no toxic side effect, suitably promoted.
Embodiment described above only expresses the several embodiments of the present invention, and its description is more concrete and detailed, but simultaneously
Therefore the restriction to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for one of ordinary skill in the art
For, without departing from the inventive concept of the premise, some deformations and improvement can also be made, these belong to the guarantor of the present invention
Shield scope.Therefore, the protection domain of patent of the present invention should be defined by claims.
Claims (10)
1. application of a kind of Chinese medicine composition in the medicine for being used for treating stomach trouble is prepared, the Chinese medicine composition include weight portion
Number is than being 15～25:1 matrimony vine and Radix Glycyrrhizae.
2. application as claimed in claim 1, it is characterised in that the ratio of weight and number of the matrimony vine and Radix Glycyrrhizae is 20:1.
3. application as claimed in claim 1, it is characterised in that the Chinese medicine composition also include following parts by weight into
Point：1～2 part of the bighead atractylodes rhizome, 0.5～1.5 part of monkshood, 1.5～2.5 parts of Medicated Leaven, 1.5～2.5 parts of the Radix Astragali, 0.5～1.5 part of wrinkled giant hyssop,
1～2 part of 0.5～1.5 part of the banksia rose and Rosa roxburghii.
4. a kind of Chinese medicine composition for treating stomach trouble, it is characterised in that the Chinese medicine composition include ratio of weight and number for 15～
25:1 matrimony vine and Radix Glycyrrhizae.
5. a kind of Chinese medicine preparation for treating stomach trouble, including the Chinese medicine composition any one of claim 4, its feature exists
In the Chinese medicine preparation is selected from tablet, capsule, pill, oral solutions or granule.
6. as claimed in claim 5 treatment stomach trouble Chinese medicine preparation, it is characterised in that the Chinese medicine preparation be tablet, described
Tablet includes 5～8 parts of 1～2 part of the Chinese medicine composition and auxiliary material, and the auxiliary material includes the composition of following parts by weight：Fill out
Fill 0.9～1.2 part of 2.5～4 parts of agent, 1～2 part of disintegrant, 0.6～0.8 part of adhesive and lubricant.
7. as claimed in claim 6 treatment stomach trouble Chinese medicine preparation, it is characterised in that the filler includes following weight portion
Several compositions：0.5～1 part of 1.5～2 parts of microcrystalline cellulose, 0.5～1 part of D-sorbite and poloxamer.
8. as claimed in claim 6 treatment stomach trouble Chinese medicine preparation, it is characterised in that the disintegrant includes following weight portion
Several compositions：0.25～0.5 part of 0.5～1 part of sodium bentonite, 0.25～0.5 part of colloidal silica and gellan gum.
9. as claimed in claim 6 treatment stomach trouble Chinese medicine preparation, it is characterised in that described adhesive includes following weight portion
Several compositions：0.1～0.15 part of 0.3～0.5 part of sodium alginate, 0.1～0.15 part of peach gum and Carbomer.
10. as claimed in claim 6 treatment stomach trouble Chinese medicine preparation, it is characterised in that the lubricant includes following weight
The composition of number：0.5～0.6 part of sodium carboxymethylcellulose, 0.2～0.3 part of magnesium laurylsulfate and Compritol 888 ATO 0.2
～0.3 part.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094959A (en) * | 1993-05-13 | 1994-11-16 | 山东省医学科学院基础医学研究所 | A kind of Chinese medicine for the treatment of gastropathy |
| CN1131553A (en) * | 1995-05-06 | 1996-09-25 | 刘润保 | Prescription of weifuyuan capsule and its preparation method |
| CN104824548A (en) * | 2015-04-09 | 2015-08-12 | 周学义 | Matrimony vine composite health care enzyme and preparation method thereof |
-
2016
- 2016-11-30 CN CN201611083357.6A patent/CN106491832A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094959A (en) * | 1993-05-13 | 1994-11-16 | 山东省医学科学院基础医学研究所 | A kind of Chinese medicine for the treatment of gastropathy |
| CN1131553A (en) * | 1995-05-06 | 1996-09-25 | 刘润保 | Prescription of weifuyuan capsule and its preparation method |
| CN104824548A (en) * | 2015-04-09 | 2015-08-12 | 周学义 | Matrimony vine composite health care enzyme and preparation method thereof |
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