CN106474172A - A kind of reducing swelling and alleviating pain ointment and preparation method thereof - Google Patents
A kind of reducing swelling and alleviating pain ointment and preparation method thereof Download PDFInfo
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- CN106474172A CN106474172A CN201611071284.9A CN201611071284A CN106474172A CN 106474172 A CN106474172 A CN 106474172A CN 201611071284 A CN201611071284 A CN 201611071284A CN 106474172 A CN106474172 A CN 106474172A
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- ointment
- alleviating pain
- reducing swelling
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- radix arnebiae
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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Abstract
The invention discloses a kind of reducing swelling and alleviating pain ointment and preparation method thereof, belong to field of traditional Chinese.Discutient and analgesic plaster calculates by weight, including：36 parts of Oleum Radix Arnebiae (Oleum Radix Lithospermi), 27 parts of thickening agent and 10 15 parts of Gypsum Fibrosum preparata.During manufacture, after Radix Arnebiae (Radix Lithospermi) is used vegetable oil fried, the Oleum Radix Arnebiae (Oleum Radix Lithospermi) obtaining and thickening agent and Gypsum Fibrosum preparata are pressed setting proportioning and mixs homogeneously, obtain mastic.Reducing swelling and alleviating pain ointment disclosed by the invention has the effect such as stronger blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic, promoting the flow of QI in the collateral by warming the meridian and cold expelling by the effect of each component coordinated, all kinds of joint of effectively treatment is acute, habitual sprain, the misery turning round the wounded can fast and effeciently be released, and can be used for athlete quickly effectively curing because of training and competition acute sprain, by above-mentioned ointment, the misery of the sick and wounded process of muscles and bones is alleviated in time rapidly on maximum degree, improves the effective percentage of ointment absorption.
Description
Technical field
The present invention relates to the technical field of traditional Chinese medical science preparation, more particularly, to a kind of reducing swelling and alleviating pain ointment and preparation method thereof.
Background technology
Sprain and refer to the indirect violences such as rotation, tractive or the fierce and inharmonic contraction of muscle, so that joint is occurred suddenly super
Go out physiological range movable when, cause muscle, tendon, ligament, fascia and joint capsule etc. tissue produce tear, fracture or shift
Deng, with local swelling, pain, the purple blue or green injury disease for mainly showing of limitation of activity and color of the leather, generally the spraining of acute grade
Commonly soft tissue injury and ligament injury.
At present, being directed to the acute treating method spraining contusion is to smear the ointment of reducing swelling and alleviating pain, now uses on the market
The reducing swelling and alleviating pain ointment for acute muscles and bones bruise be primarily present following problem：Firstth, most external-applied ointments are
Chinese herbal medicine is processed through simply morcelling blending, and thus this ointment contains that impurity component is many, and absorbable effective ingredient is few, and to skin
The zest of skin is strong, easily causes allergy；Secondth, contain anti-inflammatory analgetic class Western medicine chemical composition in part ointment, side effect is relatively
Many；3rd, most external-applied ointments solidify liquid shape using half, there is storage, carry and use the inconveniences such as process,
Often dressing must come to maintain curative effect, be restricted for needing long period fixed position to use；4th, most
The efficient functional of external-applied ointment is uneven, and it is difficult to play timely treatment, thus, the present invention is directed to acute muscles and bones bruise,
Propose a kind of reducing swelling and alleviating pain rapidly it is not easy to allergy uses, with being easy to carry, the reducing swelling and alleviating pain ointment storing.
Content of the invention
Present invention aims to weak point of the prior art, provide a kind of reducing swelling and alleviating pain ointment and its preparation
Method, preparation process is easy, low production cost, and prepared reducing swelling and alleviating pain ointment out has significant blood circulation promoting and blood stasis dispelling, temperature
Effect through dredging collateral and reducing swelling and alleviating pain, all kinds of joint of effectively treatment is acute, habitual sprain, can fast and effeciently release torsion the wounded
Misery, and can be used for athlete quickly effectively curing because of training and competition acute sprain.
For reaching this purpose, the present invention employs the following technical solutions：
A kind of reducing swelling and alleviating pain ointment, calculates by weight, including：Oleum Radix Arnebiae (Oleum Radix Lithospermi) 3-6 part, thickening agent 2-7 part and Gypsum Fibrosum preparata
10-15 part.
The deficiency existing for existing reducing swelling and alleviating pain ointment, it is main that the reducing swelling and alleviating pain ointment of the present invention adopts with Oleum Radix Arnebiae (Oleum Radix Lithospermi)
Constituent, with thickening agent and Gypsum Fibrosum preparata as adjuvant, the impurity component that it contains is few, and the property of medicine of constituent is gentle, to skin
Zest and side effect are less, the effect that each component drug effect cooperates, and have subsiding swelling and resolving stagnation, expelling wind and cold, dredge the meridian passage, disappear
Scorching pain relieving and effect of bone and muscle strengthening, reducing swelling and alleviating pain ointment is especially for spraining or dampening and play detumescence and only in acute muscles and bones
Pain act on evident in efficacy it is not easy to allergy, being directed to traumatic injury, swelling and pain due to blood stasis, all pains of muscles and bones and arthralgia has well
Therapeutic effect, without any poisonous and harmful element, both safe and effective, this reducing swelling and alleviating pain ointment has to be easy to absorb, user
Just, duration of efficacy is long, with low cost, few side effects, markedly fast and evident in efficacy the advantages of.
It is further illustrated, described Oleum Radix Arnebiae (Oleum Radix Lithospermi) is that Radix Arnebiae (Radix Lithospermi) fried rear filtration in vegetable oil obtains.
It is further illustrated, described thickening agent is Yellow Vaselin and/or hard paraffin.Yellow Vaselin is faint yellow or yellow
Color uniformly soft paste, also known as soft paraffin, odorless or almost odorless, contact soapy feeling with skin, there is certain wire drawing
Property, stable chemical nature, can be with most drug compatibility, for preparing the ointment of medicine and the raw material of skin care ointment；
The dispensing of cosmetic cream, face cream greasepaint etc.；Textile industry lubricates the emulsifying ointment of silk it can also be used to make cables manufacturing
Additive use, mainly use its insulating effect；It is used Yellow Vaselin as auxiliary element, suitably adjust except having
Beyond denseness and stretchability, when using ointment, skin wet can be kept, make the skin histology of wound location keep optimal shape
State, accelerates the repair ability of skin itself.
Hard paraffin is a kind of mineral wax, is from light lubricating oil fractions cold pressing or the cured cream of solvent dewaxing gained, through diaphoresis
Or the hydrocarbon solid obtaining after solvent deoiling, main component is C18-C30 linear paraffin, also contains isoparaffin, cycloalkane and few
Amount aromatic hydrocarbons, can be used for manufacture rubber, paraffin paper wax crayon, food and medicine group and grades, by adjusting hard paraffin come regulating
The denseness of cream, in order to use smearing ointment.
Preferably, calculate by weight, described Yellow Vaselin is 1-4 part, described hard paraffin is 1-3 part.Using upper
Stating the described Yellow Vaselin of number scope and hard paraffin is the viscosity to be adjusted ointment as suitable proportion, allows ointment
Can be formulated into required solid-state lipoid shape, carry out smearing in order to user and use and carry, make ointment easily by people simultaneously
Body skin is absorbed, and improves the drug effect efficiency of ointment.
Preferably, calculate by weight, described Oleum Radix Arnebiae (Oleum Radix Lithospermi) is 4.5 parts, described Yellow Vaselin is 2.5 parts, described solid
Paraffin is 0.75 part, described Gypsum Fibrosum preparata is 12.5 parts；The optimum formula component of the above group of reducing swelling and alleviating pain ointment being divided into the present invention,
Using this recipe ingredient, can farthest play the collaborative of each component drug effect and complementary action, drug action is higher, controls curative effect
Fruit is more notable；Especially in acute muscles and bones sprain or dampen play detumescence and analgesic effect curative effect more significantly.
It is below the specific drug effect of main component in reducing swelling and alleviating pain ointment：
Radix Arnebiae (Radix Lithospermi)：Hardship, trembles with fear；Enter percardium, Liver Channel；Removing heat from blood, heat clearing and blood circulation promoting, rash of detoxifying；For treatment warm macule, damp and hot
Jaundice, purpura, tells nosebleed hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer；Belong to comfrey Radix Arnebiae (Radix Lithospermi) (firmly purple
Grass) and lithospermum euchromum Royle (Radix Arnebiae) root, shikonin extract can suppress staphylococcus aureuses, Bacterium prodigiosum, pyogenic baeceria, large intestine bar
Bacterium etc., and epithelial growth can be accelerated, promote local wound more and and antiinflammatory action.
The Naphthaquinone Pigments containing in modern pharmacological research Radix Arnebiae (Radix Lithospermi) have good antibacterial, antiinflammatory promotes the work of wound healing
With, and the benzoquinone containing in Radix Arnebiae (Radix Lithospermi) and phenol have good analgesic effect；Its remarkable repair ability, has east lavandula angustifolia
Title, there is the antiallergic sense of brilliance, take off redness, the function of activation epidermis cell metabolism, and there is antibacterial action, there is purple simultaneously
Grass has the effect of significant anti-acne and antiinflammatory, has very big its cosmetic values, and the scope of application of Comfrey Balm is very wide, positioned at skin
On minor cut or wound, nearly all can apply Comfrey Balm come to make it restore, seem imprudence fall scratch, by knife hurt, by hot water
Scald, the xerosis cutiss that are cold cracking etc., feature and practicality have its suitable effect.
It is below that in reducing swelling and alleviating pain ointment, auxiliary element specifically acts on：
Gypsum Fibrosum preparata：Gypsum Fibrosum is carried out calcine and forms by described Gypsum Fibrosum preparata, though life, Gypsum Fibrosum preparata are jljl, its effect
Significantly different, take orally Gypsum Fibrosum, Gypsum Fibrosum preparata is mainly external more, be mainly used in removing dampness expelling pus and promoting granulation etc., Gypsum Fibrosum preparata has solidifying
Knot hardening is fast, has micro-expansibility, and porosity is big and plasticity is good, can be used as in grit, paper implant, gas dryer
And plaster bandage medically.
Thus, add described Gypsum Fibrosum in ointment, have functions that cohesion is hardening, improve the hardness of ointment, reduce ointment
Mobility so that ointment is turned into required solid-state lipoid shape, carry out smearing in order to user and use and carry storage, with
When contribute to ointment and be stably sticky on the positions such as affected part it is not necessary to the frequent dressing also effective curative effect of sustainable maintenance, improve
The drug effect efficiency of ointment so that ointment to have a storage time long, easy to carry, the spy such as easy to use and duration of efficacy length
Point.
Vegetable oil：Vegetable oil is Oleum Arachidis hypogaeae semen, yellowish transparent, mild-natured, loosening bowel to relieve constipation, and external acupoint injection therapy controls enteritis etc., institute
State vegetable oil high temperature resistant, be suitable for deep fried foodstuff.By using vegetable oil, the main component in the Radix Arnebiae (Radix Lithospermi) in ointment composition is entered
Row frying so that in Radix Arnebiae (Radix Lithospermi) most effective ingredient all blast, play mixing the major pharmaceutical component of Radix Arnebiae (Radix Lithospermi) and be immersed in
In vegetable oil, obtain preliminary Oleum Radix Arnebiae (Oleum Radix Lithospermi), in order to the follow-up allotment preparing Radix Arnebiae (Radix Lithospermi) ointment, and vegetable oil have faint antibacterial
Effect, is conducive to extending storage time and the service life of ointment.
Preferably, described reducing swelling and alleviating pain ointment is in solid-state lipoid shape.Because most external-applied ointments solidify liquid shape, storage with half
Deposit, carry, using all having inconvenience it is necessary to frequent dressing maintains curative effect, for needing long period fixed position using being subject to
To restriction.According to the demand of patient comfort's degree and use, the present invention is designed as to described balm in solid-state lipoid shape, should
Ointment carries and stores conveniently, only need to simply smear row again in affected part and wrap up, contribute to ointment stably viscous glutinous during use
On the positions such as affected part, length of holding time, without frequent dressing, there is no zest or sense of discomfort it is not easy to allergy, to ensure to suffer from
The experience of person's comfort level.
A kind of preparation method of reducing swelling and alleviating pain ointment, comprises the steps：
(1) calculate by weight, add vegetable oil 3-6 part to carry out Radix Arnebiae (Radix Lithospermi) 0.2-1 part fried, filter, obtain Radix Arnebiae (Radix Lithospermi)
Oil；
(2) add Yellow Vaselin 1-4 part to the described Oleum Radix Arnebiae (Oleum Radix Lithospermi) of step (1), hard paraffin 1-3 part is dissolved, then
Gypsum Fibrosum preparata 10-15 part is added to be stirred, until semi-solid state, placing, obtaining balm.
The component of the preparation method of the present invention is scientific and reasonable, has no toxic side effect few, formula gently non-stimulated, the infant of safety
And become can use per capita；Manufacture method easily, is in i.e. operable, is not required to add preservative, and a small amount of making is put using safety
The heart；The reducing swelling and alleviating pain ointment of the present invention not only has sterilizing and itch-relieving, reducing swelling and alleviating pain, helps the medical effects such as wound healing, also has
Have functions that whitening and skin-protecting, in particular for acute muscles and bones sprain contusion play significant reducing swelling and alleviating pain effect.
Preferably, the deep-fat frying time in described step (1) is 10-20min.The Chinese medicinal material overwhelming majority is dry product, is dried
And be of close texture, effective ingredient has crystallized or has shaped and has been deposited in intracellular, and effective medicine divides and is difficult to ooze out, using directly getting angry with oil
Frying 10-20min, can make the effective ingredient within medical material directly quickly overflow, and the efficiency of Oleum Radix Arnebiae (Oleum Radix Lithospermi) is prepared in raising, and medicine is treated
Effect substantially, therefore, the Radix Arnebiae (Radix Lithospermi) fried 10-20min of vegetable oil, is conducive to the allotment of postorder ointment, improves effective one-tenth of ointment
The drug effect content divided, strengthens the effect of the reducing swelling and alleviating pain of ointment.
Preferably, the standing time in described step (2) is 3-7 days.It is stirred until partly solid by adding Gypsum Fibrosum preparata
Body state, accelerates the setting rate of ointment, then places a couple of days, just obtains described balm.Using standing time it is
3-7 days, ointment is made to obtain abundant coagulation forming to solid-state lipoid state.If standing time is too short, Gypsum Fibrosum preparata does not have enough time to adjust
The hardness of the ointment of fluidised form shape, causes ointment to be difficult to into required form, if standing time is longer, is more conducive to improving ointment
Viscosity and hardness so that whole ointment exuberant the composition of Radix Arnebiae (Radix Lithospermi), such ointment is just easier performance function itself and treatment
The effects such as, it is easy to user and smear.
It is further illustrated, a kind of above-mentioned reducing swelling and alleviating pain ointment is used for treating muscles and bones bruise.The medicine of the present invention
Cream employs Radix Arnebiae (Radix Lithospermi) Chinese medicine and carries out making ointment, and ointment has dispelling wind and removing obstruction in the collateral, relaxing muscles and tendons to promote blood circulation, the work(of reducing swelling and alleviating pain and sterilization antiinflammatory
Effect, the performance that can be simultaneous for multiple diseases also has good effect, especially, for the acute outside such as muscles and bones bruise
Injury, reaches the fast treatment mesh ground of curative effect, dispels because spraining or dampening the symptoms such as the bones and muscles pain causing, from there through above-mentioned group
Divide the ointment of preparation, the effect such as blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian and reducing swelling and alleviating pain is higher it is ensured that the speed of component drug effect performance is mutual
Cooperation, makes component drug effect play maximum, improve the absorbance of effective point of balm so that ointment reach best
The therapeutic effect of reducing swelling and alleviating pain.
The reducing swelling and alleviating pain ointment of the present invention adopts with Oleum Radix Arnebiae (Oleum Radix Lithospermi) as main constituents, supplemented by thickening agent and Gypsum Fibrosum preparata
Material, has the effect such as stronger blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic, promoting the flow of QI in the collateral by warming the meridian and cold expelling by the effect of each component coordinated, its
The impurity component containing is few, and the property of medicine of constituent is gentle, less to skin irritation and side effect, can be widely applied to treat
The pains of injury such as muscles and bones joint, especially in acute muscles and bones sprain or dampen play detumescence and analgesic effect evident in efficacy, simultaneously
Have with low cost, carry easy to use, safe, few side effects, duration of efficacy length, markedly fast and evident in efficacy etc.
Advantage, by above-mentioned ointment, alleviates rapidly the misery of the sick and wounded process of muscles and bones in maximum degree, improves ointment and absorbs
Effective percentage, meet the market demand of traditional Chinese medicine industry.
Radix Arnebiae (Radix Lithospermi) can be fried into Oleum Radix Arnebiae (Oleum Radix Lithospermi) by the manufacture method of the reducing swelling and alleviating pain ointment of the present invention, add thickening agent and Gypsum Fibrosum preparata
Allocated, be adjusted to into the ointment of required solid-state lipoid shape, operational approach is simple, with low cost, efficient and convenient, you can system
Standby go out above-mentioned reducing swelling and alleviating pain ointment.
Specific embodiment
The present invention program is described in detail below by some specific embodiments.Those skilled in the art should manage
Solution, following be embodied as preferred embodiment, it only explains to the present invention program, and wherein might have to known skill
The suitable omission of art, those skilled in the art should understand to the present invention in conjunction with the explanation of known technology and embodiment.
A kind of reducing swelling and alleviating pain ointment, calculates by weight, including：Oleum Radix Arnebiae (Oleum Radix Lithospermi) 3-6 part, thickening agent 2-7 part and Gypsum Fibrosum preparata
10-15 part.
The deficiency existing for existing reducing swelling and alleviating pain ointment, it is main that the reducing swelling and alleviating pain ointment of the present invention adopts with Oleum Radix Arnebiae (Oleum Radix Lithospermi)
Constituent, with thickening agent and Gypsum Fibrosum preparata as adjuvant, the impurity component that it contains is few, and the property of medicine of constituent is gentle, to skin
Zest and side effect are less, the effect that each component drug effect cooperates, and have subsiding swelling and resolving stagnation, expelling wind and cold, dredge the meridian passage, disappear
Scorching pain relieving and effect of bone and muscle strengthening, reducing swelling and alleviating pain ointment is especially for spraining or dampening and play detumescence and only in acute muscles and bones
Pain act on evident in efficacy it is not easy to allergy, being directed to traumatic injury, swelling and pain due to blood stasis, all pains of muscles and bones and arthralgia has well
Therapeutic effect, without any poisonous and harmful element, both safe and effective, this reducing swelling and alleviating pain ointment has to be easy to absorb, user
Just, duration of efficacy is long, with low cost, few side effects, markedly fast and evident in efficacy the advantages of.
It is further illustrated, described Oleum Radix Arnebiae (Oleum Radix Lithospermi) is that Radix Arnebiae (Radix Lithospermi) fried rear filtration in vegetable oil obtains.
It is further illustrated, described thickening agent is Yellow Vaselin and/or hard paraffin.Yellow Vaselin is faint yellow or yellow
Color uniformly soft paste, also known as soft paraffin, odorless or almost odorless, contact soapy feeling with skin, there is certain wire drawing
Property, stable chemical nature, can be with most drug compatibility, for preparing the ointment of medicine and the raw material of skin care ointment；
The dispensing of cosmetic cream, face cream greasepaint etc.；Textile industry lubricates the emulsifying ointment of silk it can also be used to make cables manufacturing
Additive use, mainly use its insulating effect；It is used Yellow Vaselin as auxiliary element, suitably adjust except having
Beyond denseness and stretchability, when using ointment, skin wet can be kept, make the skin histology of wound location keep optimal shape
State, accelerates the repair ability of skin itself.
Hard paraffin is a kind of mineral wax, is from light lubricating oil fractions cold pressing or the cured cream of solvent dewaxing gained, through diaphoresis
Or the hydrocarbon solid obtaining after solvent deoiling, main component is C18-C30 linear paraffin, also contains isoparaffin, cycloalkane and few
Amount aromatic hydrocarbons, can be used for manufacture rubber, paraffin paper wax crayon, food and medicine group and grades, by adjusting hard paraffin come regulating
The denseness of cream, in order to use smearing ointment.
Preferably, calculate by weight, described Yellow Vaselin is 1-4 part, described hard paraffin is 1-3 part.Using upper
Stating the described Yellow Vaselin of number scope and hard paraffin is the viscosity to be adjusted ointment as suitable proportion, allows ointment
Can be formulated into required solid-state lipoid shape, carry out smearing in order to user and use and carry, make ointment easily by people simultaneously
Body skin is absorbed, and improves the drug effect efficiency of ointment.
Preferably, calculate by weight, described Oleum Radix Arnebiae (Oleum Radix Lithospermi) is 4.5 parts, described Yellow Vaselin is 2.5 parts, described solid
Paraffin is 0.75 part, described Gypsum Fibrosum preparata is 12.5 parts；The optimum formula component of the above group of reducing swelling and alleviating pain ointment being divided into the present invention,
Using this recipe ingredient, can farthest play the collaborative of each component drug effect and complementary action, drug action is higher, controls curative effect
Fruit is more notable；Especially in acute muscles and bones sprain or dampen play detumescence and analgesic effect curative effect more significantly.Above-mentioned
Explain drug effect or the effect of each component, thus just no longer burden elaboration one by one here.
Preferably, described reducing swelling and alleviating pain ointment is in solid-state lipoid shape.Because most external-applied ointments solidify liquid shape, storage with half
Deposit, carry, using all having inconvenience it is necessary to frequent dressing maintains curative effect, for needing long period fixed position using being subject to
To restriction.According to the demand of patient comfort's degree and use, the present invention is designed as to described balm in solid-state lipoid shape, should
Ointment carries and stores conveniently, only need to simply smear row again in affected part and wrap up, contribute to ointment stably viscous glutinous during use
On the positions such as affected part, length of holding time, without frequent dressing, there is no zest or sense of discomfort it is not easy to allergy, to ensure to suffer from
The experience of person's comfort level.
A kind of preparation method of reducing swelling and alleviating pain ointment, comprises the steps：
(1) calculate by weight, add vegetable oil 3-6 part to carry out Radix Arnebiae (Radix Lithospermi) 0.2-1 part fried, filter, obtain Radix Arnebiae (Radix Lithospermi)
Oil；
(2) add Yellow Vaselin 1-4 part to the described Oleum Radix Arnebiae (Oleum Radix Lithospermi) of step (1), hard paraffin 1-3 part is dissolved, then
Gypsum Fibrosum preparata 10-15 part is added to be stirred, until semi-solid state, placing, obtaining balm.
The component of the preparation method of the present invention is scientific and reasonable, has no toxic side effect few, formula gently non-stimulated, the infant of safety
And become can use per capita；Manufacture method easily, is in i.e. operable, is not required to add preservative, and a small amount of making is put using safety
The heart；The reducing swelling and alleviating pain ointment of the present invention not only has sterilizing and itch-relieving, reducing swelling and alleviating pain, helps the medical effects such as wound healing, also has
Have functions that whitening and skin-protecting, in particular for acute muscles and bones sprain contusion play significant reducing swelling and alleviating pain effect.
Preferably, the deep-fat frying time in described step (1) is 10-20min.The Chinese medicinal material overwhelming majority is dry product, is dried
And be of close texture, effective ingredient has crystallized or has shaped and has been deposited in intracellular, and effective medicine divides and is difficult to ooze out, using directly getting angry with oil
Frying 10-20min, can make the effective ingredient within medical material directly quickly overflow, and the efficiency of Oleum Radix Arnebiae (Oleum Radix Lithospermi) is prepared in raising, and medicine is treated
Effect substantially, therefore, the Radix Arnebiae (Radix Lithospermi) fried 10-20min of vegetable oil, is conducive to the allotment of postorder ointment, improves effective one-tenth of ointment
The drug effect content divided, strengthens the effect of the reducing swelling and alleviating pain of ointment.
Preferably, the standing time in described step (2) is 3-7 days.It is stirred until partly solid by adding Gypsum Fibrosum preparata
Body state, accelerates the setting rate of ointment, then places a couple of days, just obtains described balm.Using standing time it is
3-7 days, ointment is made to obtain abundant coagulation forming to solid-state lipoid state.If standing time is too short, Gypsum Fibrosum preparata does not have enough time to adjust
The hardness of the ointment of fluidised form shape, causes ointment to be difficult to into required form, if standing time is longer, is more conducive to improving ointment
Viscosity and hardness so that whole ointment exuberant the composition of Radix Arnebiae (Radix Lithospermi), such ointment is just easier performance function itself and treatment
The effects such as, it is easy to user and smear.
It is further illustrated, a kind of above-mentioned reducing swelling and alleviating pain ointment is used for treating muscles and bones bruise.The medicine of the present invention
Cream employs Radix Arnebiae (Radix Lithospermi) Chinese medicine and carries out making ointment, and ointment has dispelling wind and removing obstruction in the collateral, relaxing muscles and tendons to promote blood circulation, the work(of reducing swelling and alleviating pain and sterilization antiinflammatory
Effect, the performance that can be simultaneous for multiple diseases also has good effect, especially, for the acute outside such as muscles and bones bruise
Injury, reaches the fast treatment mesh ground of curative effect, dispels because spraining or dampening the symptoms such as the bones and muscles pain causing, from there through above-mentioned group
Divide the ointment of preparation, the effect such as blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian and reducing swelling and alleviating pain is higher it is ensured that the speed of component drug effect performance is mutual
Cooperation, makes component drug effect play maximum, improve the absorbance of effective point of balm so that ointment reach best
The therapeutic effect of reducing swelling and alleviating pain.
With reference to specific embodiment, the present invention is described in detail.
Embodiment 1：
Radix Arnebiae (Radix Lithospermi), 0.2 part adds 3 parts of vegetable oil to carry out fried 20min, filters, obtains Oleum Radix Arnebiae (Oleum Radix Lithospermi), add to described Oleum Radix Arnebiae (Oleum Radix Lithospermi)
Enter 1 part of Yellow Vaselin, 1 part of hard paraffin is dissolved, be subsequently adding 10 parts of Gypsum Fibrosum preparata and be stirred, until semi-solid state, putting
Put 7 days, obtain balm.
Embodiment 2：
Radix Arnebiae (Radix Lithospermi), 1 part adds 6 parts of vegetable oil to carry out fried 20min, filters, obtains Oleum Radix Arnebiae (Oleum Radix Lithospermi), adds to described Oleum Radix Arnebiae (Oleum Radix Lithospermi)
4 parts of Yellow Vaselin, 3 parts of hard paraffin is dissolved, and is subsequently adding 15 parts of Gypsum Fibrosum preparata and is stirred, until semi-solid state, placing
7 days, obtain balm.
Embodiment 3：
Radix Arnebiae (Radix Lithospermi), 0.8 part adds 3 parts of vegetable oil to carry out fried 20min, filters, obtains Oleum Radix Arnebiae (Oleum Radix Lithospermi), add to described Oleum Radix Arnebiae (Oleum Radix Lithospermi)
Enter 1.5 parts of Yellow Vaselin, 3.5 parts of hard paraffin is dissolved, be subsequently adding 13.5 parts of Gypsum Fibrosum preparata and be stirred until semisolid
State, places 7 days, obtains balm.
Embodiment 4：
Radix Arnebiae (Radix Lithospermi), 0.4 part adds 5 parts of vegetable oil to carry out fried 20min, filters, obtains Oleum Radix Arnebiae (Oleum Radix Lithospermi), add to described Oleum Radix Arnebiae (Oleum Radix Lithospermi)
Enter 3 parts of Yellow Vaselin, 2 parts of hard paraffin is dissolved, be subsequently adding 13 parts of Gypsum Fibrosum preparata and be stirred, until semi-solid state, putting
Put 7 days, obtain balm.
Embodiment 5：
Radix Arnebiae (Radix Lithospermi), 0.6 part adds 4 parts of vegetable oil to carry out fried 20min, filters, obtains Oleum Radix Arnebiae (Oleum Radix Lithospermi), add to described Oleum Radix Arnebiae (Oleum Radix Lithospermi)
Enter 2 parts of Yellow Vaselin, 1.5 parts of hard paraffin is dissolved, be subsequently adding 12 parts of Gypsum Fibrosum preparata and be stirred until semi-solid state,
Place 7 days, obtain balm.
Embodiment 6：
Radix Arnebiae (Radix Lithospermi), 0.5 part adds 4.5 parts of vegetable oil to carry out fried 20min, filters, obtains Oleum Radix Arnebiae (Oleum Radix Lithospermi), to described Oleum Radix Arnebiae (Oleum Radix Lithospermi)
Add 2.5 parts of Yellow Vaselin, 0.75 part of hard paraffin is dissolved, be subsequently adding 12.5 parts of Gypsum Fibrosum preparata and be stirred until partly solid
Body state, places 7 days, obtains balm.
Comparative example 1：
Radix Arnebiae (Radix Lithospermi), 0.5 part adds 4.5 parts of vegetable oil to carry out fried 20min, filters, obtains Oleum Radix Arnebiae (Oleum Radix Lithospermi), to described Oleum Radix Arnebiae (Oleum Radix Lithospermi)
Add 2.5 parts of Yellow Vaselin to be dissolved, be subsequently adding 12.5 parts of Gypsum Fibrosum preparata and be stirred, until semi-solid state, placing 7 days,
Obtain contrasting balm.
Note：This product is not add hard paraffin component.
Comparative example 2：
Radix Arnebiae (Radix Lithospermi), 0.5 part adds 4.5 parts of vegetable oil to carry out fried 20min, filters, obtains Oleum Radix Arnebiae (Oleum Radix Lithospermi), to described Oleum Radix Arnebiae (Oleum Radix Lithospermi)
Add 0.75 part of hard paraffin to be dissolved, be subsequently adding 12.5 parts of Gypsum Fibrosum preparata and be stirred, until semi-solid state, placing 7
My god, obtain contrasting balm.
Note：This product is not add Yellow Vaselin component.
Comparative example 3：
Radix Arnebiae (Radix Lithospermi), 0.5 part adds 4.5 parts of vegetable oil to carry out fried 20min, filters, obtains Oleum Radix Arnebiae (Oleum Radix Lithospermi), to described Oleum Radix Arnebiae (Oleum Radix Lithospermi)
Add 2.5 parts of Yellow Vaselin, 0.75 part of hard paraffin carries out dissolving stirring, places 7 days, obtain contrasting balm.
Note：This product is not add Gypsum Fibrosum preparata component.
Balm for each embodiment and comparative example preparation carries out effect proof property test.
Clinical testing data：Selection Fushan City, Guangdong Province 130 is sprained patient and is carried out clinical observation treatment, wherein man 65
Example, female 65, age 11-58 year, 37 years old mean age.Sprain in patient for 130, lumbar strain patient 20, ankle sprain
Patient 20, knee sprain patient 18, shoulder sprains patient 16, wrist sprains patient 18, ancon sprains patient 18,
Hip sprains patient 20；Above patients symptomatic have following some one of or two or more：Sprain position local swelling, severe pain,
Limitation of activity, joint subcutaneous extvavasated blood form hematoma.
Above 130 patient's stochastic averagina are divided into Liang Ge treatment group, each treatment group 65, wherein treatment group 1 adopt
The balm of embodiment 1-6 preparation is treated, and treatment group 2 is entered using contrast balm prepared by comparative example 1-3
Row treatment.
The using method of the Chinese medicine preparation that the treatment of the present invention is sprained：To sprain after position cleans up, use medical cotton stick
The balm dipping the present invention is smeared, and natural gift are sooner or later each to clean once, is within three days a course for the treatment of；Then proceed in experiment
After 3rd day, after recording its treatment, state (inclusion is sprained position symptom and improved situation, untoward reaction etc.) is scored, and (scoring is marked
Accurate corresponding table see table 1), the recovery from illness institute of each patient is counted using the number of times of ointment and the number of recovery from illness simultaneously, record
With calculate cure rate, obtained experimental result see table 2- table 3.
Table 1 standards of grading correspond to table
Table 2 embodiment 1-6 therapeutic effect is tested
As seen from the results in Table 1:
(1) pass through the contrast of embodiment 1-6 as can be seen that the ointment component of embodiment 6 and consumption are optimum formula, embodiment
After spraining the treatment of patient in 6, the said components of score ratio embodiment 1-5 that scores of state is high, and the number that treatment is cured is wanted
Many, for the curative effect sprained preferably, the corresponding numerical value in value range of other components has corresponding change, and patient is after three days
All can reach the therapeutic effect of recovery from illness, do not observe untoward reaction.
Table 3 comparative example's 1-3 therapeutic effect is tested
As seen from the results in Table 3:
(1) pass through comparative example 1-3 contrast as can be seen that when other components are necessarily constant, without Yellow Vaselin,
Hard paraffin and Gypsum Fibrosum preparata a certain component therein, after the treatment of patient, the scoring fraction of state is not high, belong to patients with mild with
Between recovery from illness patient, treatment number is in medium level, the treatment that patient has some of the staff not reach recovery from illness after testing three days
Effect.
From table 2 and 3 results:
(1) embodiment 6 and comparative example 1-3 contrast are passed through as can be seen that when other components are necessarily constant, without
Yellow Vaselin, hard paraffin and Gypsum Fibrosum preparata a certain component therein, after spraining the treatment of patient, the scoring score ratio of state is implemented
Example 6 all adds the low of said components, and treatment number will be lacked, and patient has some of the staff not reach recovery from illness after testing three days
Therapeutic effect.
In sum, the reducing swelling and alleviating pain ointment of the present invention adopts with Radix Arnebiae (Radix Lithospermi) as main constituents, with thickening agent, Gypsum Fibrosum preparata
It is adjuvant with vegetable oil, stronger blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic, promoting the flow of QI in the collateral by warming the meridian are had by the effect of each component coordinated and dissipates
Cold wait effect, can be widely applied to treat the pains of injury such as muscles and bones joint, all kinds of joint of effectively treatment is acute, habitual sprain, can be fast
Speed releases the misery turning round the wounded effectively, and can be used for athlete quickly effectively curing because of training and competition acute sprain, passes through
Above-mentioned ointment, alleviates rapidly the misery of the sick and wounded process of muscles and bones in maximum degree, improves the effective percentage of ointment absorption,
Meet the market demand of traditional Chinese medicine industry, market prospect is considerable.
The above-mentioned description to embodiment is to be understood that and use invention for ease of those skilled in the art.
Person skilled in the art obviously easily can make various modifications to these embodiments, and described herein general
Principle is applied in other embodiment without through performing creative labour.Therefore, the invention is not restricted to above-described embodiment, ability
, according to the announcement of the present invention, the improvement made without departing from scope and modification all should be the present invention's for field technique personnel
Within protection domain.
Claims (10)
1. a kind of reducing swelling and alleviating pain ointment is it is characterised in that calculate by weight, including：Oleum Radix Arnebiae (Oleum Radix Lithospermi) 3-6 part, thickening agent 2-7 part
With Gypsum Fibrosum preparata 10-15 part.
2. a kind of reducing swelling and alleviating pain ointment according to claim 1 is it is characterised in that described Oleum Radix Arnebiae (Oleum Radix Lithospermi) is Radix Arnebiae (Radix Lithospermi) in vegetable oil
In fried after filter obtain.
3. a kind of reducing swelling and alleviating pain ointment according to claim 1 it is characterised in that described thickening agent be Yellow Vaselin and/
Or hard paraffin.
4., it is characterised in that calculating by weight, described Huang is all for a kind of reducing swelling and alleviating pain ointment according to claim 1
Intellectual circle is 1-4 part, and described hard paraffin is 1-3 part.
5. a kind of reducing swelling and alleviating pain ointment according to claim 4 is it is characterised in that calculate by weight, described Radix Arnebiae (Radix Lithospermi)
Oil is 4.5 parts, described Yellow Vaselin is 2.5 parts, described hard paraffin is 0.75 part, described Gypsum Fibrosum preparata is 12.5 parts.
6. a kind of reducing swelling and alleviating pain ointment according to claim 1 is it is characterised in that described reducing swelling and alleviating pain ointment coagulates in solid-state
Smectic.
7. a kind of preparation method of reducing swelling and alleviating pain ointment is it is characterised in that comprise the steps：
(1) calculate by weight, add vegetable oil 3-6 part to carry out Radix Arnebiae (Radix Lithospermi) 0.2-1 part fried, filter, obtain Oleum Radix Arnebiae (Oleum Radix Lithospermi)；
(2) add Yellow Vaselin 1-4 part to the described Oleum Radix Arnebiae (Oleum Radix Lithospermi) of step (1), hard paraffin 1-3 part is dissolved, and is subsequently adding
The stirring of Gypsum Fibrosum preparata 10-15 part, until semi-solid state, is placed, is obtained balm.
8. a kind of preparation method of reducing swelling and alleviating pain ointment according to claim 7 is it is characterised in that in described step (1)
Deep-fat frying time be 10-20min.
9. a kind of preparation method of reducing swelling and alleviating pain ointment according to claim 7 is it is characterised in that in described step (2)
Standing time be 3-7 days.
10. a kind of reducing swelling and alleviating pain ointment as described in any one in claim 1-6 is used for treating muscles and bones bruise.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416859A (en) * | 2002-12-03 | 2003-05-14 | 赵淑文 | Externally applied Chinese medicine with functions of diminishing inflammation, promoting granulation, stopping itch and stopping pain and its prepn process |
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2016
- 2016-11-29 CN CN201611071284.9A patent/CN106474172A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416859A (en) * | 2002-12-03 | 2003-05-14 | 赵淑文 | Externally applied Chinese medicine with functions of diminishing inflammation, promoting granulation, stopping itch and stopping pain and its prepn process |
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