CN106472535A - A kind of new and effective Pesticidal combination - Google Patents
A kind of new and effective Pesticidal combination Download PDFInfo
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- CN106472535A CN106472535A CN201610777847.XA CN201610777847A CN106472535A CN 106472535 A CN106472535 A CN 106472535A CN 201610777847 A CN201610777847 A CN 201610777847A CN 106472535 A CN106472535 A CN 106472535A
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- effective
- pesticidal combination
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- trifluoro
- ethiprole
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- 230000000361 pesticidal effect Effects 0.000 title claims abstract description 29
- FNELVJVBIYMIMC-UHFFFAOYSA-N Ethiprole Chemical compound N1=C(C#N)C(S(=O)CC)=C(N)N1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl FNELVJVBIYMIMC-UHFFFAOYSA-N 0.000 claims abstract description 55
- 239000000203 mixture Substances 0.000 claims abstract description 23
- HVQHXBNMBZJPLK-UHFFFAOYSA-N 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-[(2-methylprop-2-en-1-yl)amino]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound CC(=C)CNC1=C([S+]([O-])C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl HVQHXBNMBZJPLK-UHFFFAOYSA-N 0.000 claims abstract description 21
- 241000607479 Yersinia pestis Species 0.000 claims abstract description 20
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 17
- 239000000470 constituent Substances 0.000 claims abstract description 14
- 239000002917 insecticide Substances 0.000 claims abstract description 13
- 239000004615 ingredient Substances 0.000 claims abstract description 10
- OEDUIFSDODUDRK-UHFFFAOYSA-N 5-phenyl-1h-pyrazole Chemical group N1N=CC=C1C1=CC=CC=C1 OEDUIFSDODUDRK-UHFFFAOYSA-N 0.000 claims abstract description 7
- 241001498622 Cixius wagneri Species 0.000 claims abstract description 5
- 241000270322 Lepidosauria Species 0.000 claims abstract description 4
- 230000000694 effects Effects 0.000 claims description 20
- 241000238631 Hexapoda Species 0.000 claims description 16
- 239000000375 suspending agent Substances 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000003094 microcapsule Substances 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- 239000002552 dosage form Substances 0.000 claims description 7
- 239000011248 coating agent Substances 0.000 claims description 6
- 230000000749 insecticidal effect Effects 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 6
- 239000002270 dispersing agent Substances 0.000 claims description 5
- 239000004563 wettable powder Substances 0.000 claims description 5
- 239000003995 emulsifying agent Substances 0.000 claims description 4
- 239000006185 dispersion Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 239000000080 wetting agent Substances 0.000 claims description 3
- AJKNNUJQFALRIK-UHFFFAOYSA-N 1,2,3-trifluorobenzene Chemical compound FC1=CC=CC(F)=C1F AJKNNUJQFALRIK-UHFFFAOYSA-N 0.000 claims description 2
- 241001600407 Aphis <genus> Species 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 244000045947 parasite Species 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- JWXJRRHHNXLANU-UHFFFAOYSA-N pyrimidine 1,2,3-trifluorobenzene Chemical compound N1=CN=CC=C1.FC=1C(=C(C=CC1)F)F JWXJRRHHNXLANU-UHFFFAOYSA-N 0.000 abstract description 54
- 239000000575 pesticide Substances 0.000 abstract description 11
- 241001124076 Aphididae Species 0.000 abstract description 8
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 238000003912 environmental pollution Methods 0.000 abstract 1
- 230000001151 other effect Effects 0.000 abstract 1
- 244000144977 poultry Species 0.000 abstract 1
- 238000000034 method Methods 0.000 description 30
- 241001425390 Aphis fabae Species 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- 239000002994 raw material Substances 0.000 description 11
- 241001556089 Nilaparvata lugens Species 0.000 description 10
- 230000002265 prevention Effects 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 239000004562 water dispersible granule Substances 0.000 description 9
- 231100000419 toxicity Toxicity 0.000 description 8
- 230000001988 toxicity Effects 0.000 description 8
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 240000007594 Oryza sativa Species 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- 239000005995 Aluminium silicate Substances 0.000 description 5
- 235000007164 Oryza sativa Nutrition 0.000 description 5
- 235000012211 aluminium silicate Nutrition 0.000 description 5
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- 241001648788 Margarodidae Species 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 4
- 230000008485 antagonism Effects 0.000 description 4
- 239000000440 bentonite Substances 0.000 description 4
- 229910000278 bentonite Inorganic materials 0.000 description 4
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 4
- -1 butene-fipronil compound Chemical class 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 230000000149 penetrating effect Effects 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 235000009566 rice Nutrition 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 231100000820 toxicity test Toxicity 0.000 description 4
- 238000009736 wetting Methods 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 239000004141 Sodium laurylsulphate Substances 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 239000002689 soil Substances 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 206010011732 Cyst Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000012271 agricultural production Methods 0.000 description 2
- 230000002528 anti-freeze Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 208000031513 cyst Diseases 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000007667 floating Methods 0.000 description 2
- 238000003958 fumigation Methods 0.000 description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 229920002689 polyvinyl acetate Polymers 0.000 description 2
- 239000011118 polyvinyl acetate Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- LPXFITACVAQQAL-UHFFFAOYSA-M sodium;prop-2-enoylazanide Chemical compound [Na+].[NH-]C(=O)C=C LPXFITACVAQQAL-UHFFFAOYSA-M 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- 239000012991 xanthate Substances 0.000 description 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
- 241001136249 Agriotes lineatus Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241001414720 Cicadellidae Species 0.000 description 1
- 241000254173 Coleoptera Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000289763 Dasygaster padockina Species 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 244000037666 field crops Species 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000003063 flame retardant Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 150000008048 phenylpyrazoles Chemical class 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 150000003219 pyrazolines Chemical class 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of new and effective Pesticidal combination and its application, it is related to technical field of pesticide combination.Pesticidal combination of the present invention comprises effective constituents A and B.Effective constituents A is trifluoro-benzene pyrimidine, and effective ingredient B is Phenylpyrazole insecticides ethiprole or butene-fipronil, and wherein effective constituents A and B weight ratio are 1：60～40：1, preferably 1：30～20：1.Above-mentioned built agent reasonable mixture ratio, have significant synergies, particularly excellent to sucking pest such as aphid, planthopper, a red-spotted lizard, flea, louse and other effects, the amount of application of each single dose can effectively be reduced, reach and delay Drug resistance, mitigate environmental pollution, strengthen to person poultry safety's property, there is obvious application and popularization value.
Description
Technical field
The present invention relates to technical field of pesticide combination, more particularly to one kind are killed containing trifluoro-benzene pyrimidine and phenyl pyrazoles
Worm agent ethiprole or the new and effective Pesticidal combination of butene-fipronil.
Background technology
In the real process of agricultural production, chemical prevention remains the most effective means of pest control, but due to chemistry
The lasting and substantial amounts of use of insecticide, pest resistance to insecticide problem constantly projects.Various effect of chemical control are decreased obviously, prevent
Control cost to improve constantly.
Trifluoro-benzene pyrimidine belongs to mesoionic insecticides, and mechanism of action is unique, and various suckings pest are had very
Good prevention effect.
Ethiprole is a kind of Phenylpyrazole insecticides, and insecticidal spectrum is wide, to insect based on stomach poison function, have concurrently tag and
Certain systemic action, its insecticidal mechanism be hinder insecticide γ-aminobutyric acid control chloride metabolism, therefore to aphid,
The important pests such as leafhopper, plant hopper, lepidopterous larvae, flies and coleoptera have very high insecticidal activity, to crop no poisoning.Can apply
In soil, also can foliar spray.Impose on soil and can effectively prevent and treat corn root leaf A, wireworm and cutworm.
Butene-fipronil is also Phenylpyrazole insecticides, is Ruize Farm-Chemicals Co., Ltd., Dalian on ethiprole basis
The noval chemical compound of upper exploitation.With ethiprole, there is same isoreactivity, simultaneously as this medicament is to Fish low toxicity, for it in Oryza sativa L., vegetable
Application in dish, health opens wider array of space.
For the insect in preventing and treating agricultural production and resistant insect, a kind of method be release new with existing kind no interactions
The new component of resistance.But, the development cost of new effective ingredient is high, and the construction cycle is long, usual cost billions of dollars, lasts 5
More than year, and once resistance, often resulting in chemical control lost efficacy, and is forced to disable or eliminates.And develop medicament generally all
Produce the speed of resistance less than insect.Other methods such as crop structure adjustment, different pesticide rotation etc., in practical operation
During, it is difficult to really play obvious effect.
The mixed of insecticide is one of most useful means in current Chemical Control of Harmful Insects.Agriculture chemical compounding have potentiation, addition,
Three kinds of distinct results of antagonism, compounding between even two kinds pesticide, because proportioning difference potentiation degree is also different,
The even antagonism having.The obvious compositionss of potentiation selected by testing sieve, not only can improve the preventive effect to insect,
Reduce the usage amount of chemical pesticide, reduce production cost, and delay the generation of pest resistance to insecticide.
Content of the invention
It is an object of the invention to provide a kind of good disinsection effect, the low Pesticidal combination of drug cost.It is mainly used in preventing
Control sucking pest such as aphid, planthopper, a red-spotted lizard, flea, louse etc..
In order to reach object above, the present invention is achieved by the following technical solutions：
A kind of new and effective Pesticidal combination of the present invention, comprises effective constituents A and B, and effective constituents A is trifluoro-benzene
Pyrimidine, effective ingredient B is Phenylpyrazole insecticides ethiprole or butene-fipronil, and wherein, described effective constituents A becomes with effectively
The weight of point B ratio is for 1：60～40：1.
Further, the weight of effective constituents A and effective ingredient B is than for 1：30～20：1.
Further, the weight of effective constituents A and effective ingredient B is than for 1：15～10：1.
Also contain pesticidal preparations auxiliary element in Pesticidal combination of the present invention, be suitable for agriculturally using to make
Dosage form.
Pesticidal preparations auxiliary element of the present invention is solvent, emulsifying agent, dispersant, stabilizer, antifreezing agent, in wetting agent
At least one.
Pesticidal combination of the present invention, according to the method well known to those skilled in the art of the present technique, can be configured to be suitable for
Arbitrary dosage form of agricultural use, preferable dosage form is can be suspension seed-coating agent, wet seed dressing, fumicants, suspending agent, microcapsule suspension
Agent, wettable powder, water dispersion granule.
Pesticidal combination of the present invention, can apply to prevent and treat the application of plant and health and pest.Particularly apply
Preparation in the preparation of controlling sucking insects.Be particularly applied to anti-eliminate aphis, planthopper, a red-spotted lizard, flea, the pesticide system of louse etc.
The preparation of agent.
Pesticidal combination of the present invention can be provided with finished product preparation form, and that is, in compositionss, each material has mixed
Close, or the composition of compositionss can also be provided with unit dose form, directly mixed in bucket or tank using front, be then diluted to
Required concentration.
The method that Pesticidal combination of the present invention is applied to prevention and elimination of disease and pests, active component A and component B are with above-mentioned
Than applying, it can apply after being mixed in proportion, apply in proportion simultaneously or apply successively in proportion weight.Concrete method of application can
Be powder injection process, smog method, fumigation and steaming method, seed treatment, soil treatment method, ultra low volume spray, mix fertile method, broadcast application and
Root-pouring method.
Compared with prior art, the invention has the beneficial effects as follows：1st, compared with single dose, compounding have obvious Synergistic
Effect, improves prevention effect；2nd, compositionss are made up of two kinds of different effective ingredient of mechanism of action, good disinsection effect, favorably
In overcoming and delay drug-fast generation；3rd, medicament mixture decreases dosage, thus reducing cost and alleviating to environment
Pollution.
Specific embodiment
With reference to embodiment, the present invention is further illustrated.
For making the technical problem to be solved in the present invention, technical scheme and advantage clearer, specific embodiment will be used below
It is described in detail, but the present invention is limited to absolutely not these examples.Described below be only the preferable embodiment of the present invention, only in order to
Explain the present invention, therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that all the present invention's
Any modification, equivalent and improvement made within spirit and principle etc., should be included within the scope of the present invention.
Therefore, the protection domain of patent of the present invention should be defined by claims.
The combination of active principles of different pesticide is made pesticide, is to develop and develop novel pesticide at present and prevent and treat agriculturally
A kind of effective and quick way of resistance pathogenic bacteria.After the pestsides synthesis of different cultivars, typically exhibit a large amount of three kinds of effect classes
Type：Summation action, potentiation and antagonism.The good formula of compound synergic, can significantly improve actual prevention effect, fall
The usage amount of low pesticide, thus contributing to delaying drug-fast generation speed, is the important means of integrated control pest and disease damage.
Present composition effective ingredient is A and B, and wherein, effective constituents A is trifluoro-benzene pyrimidine, and effective ingredient B is phenyl
Insecticidal pyrazolines ethiprole or butene-fipronil, combine between them and have obvious synergistic function to pest control,
And be not only two kinds of pharmacy effects simple superposition, this can be clearly understood that from following test result.
In order to prevent and treat harmful organism sucking pest, inventor is with trifluoro-benzene pyrimidine and Phenylpyrazole insecticides ethiprole
Or the potentiation research that two kinds of compositions of butene-fipronil are mutually compounded respectively.Test adopts bean aphid, Brown Planthopper
For test object, concrete grammar is：
Indoor biometricses compound screening is tested：
Reagent agent：Trifluoro-benzene pyrimidine active compound, ethiprole active compound, butene-fipronil active compound
Selected insect source：
Bean aphid：In May, 2014 picks up from Ganzhou City sandstone town Semen Viciae fabae ground, and the Semen Viciae fabae Seedling using no medicine is raised,
Raising temperature is 25 ± 1 DEG C, relative humidity 60%-75%, and the photoperiod is 14：10h(L：D).
Brown Planthopper：In July, 2014 picks up from Ganzhou City sandstone town rice terrace, indoors with not contacting the Shan of medicament
Excellent 63 rice plants are raised, and raising temperature is 27 ± 1 DEG C, relative humidity 60%-80%, and the photoperiod is 16：8h(L：D).
Test method：
Bean aphid assay method：Using FAO (Food and Agriculture Organization of the United Nation) recommend infusion process carry out toxicity test (FAO,
1980).With on brush pen rejecting blade, less aphid is individual and has wing adult aphid, make the first-born long hair of 50-70 is retained on every leaf
Educate consistent aptery adult aphid.Leaf with aphid is impregnated 10s in the medicinal liquid preparing, it is unnecessary to be blotted with filter paper after taking-up
Medicinal liquid, encases petiole base immersion moisturizing with absorbent paper, puts in disposal plastic cup and with gauze and rubber band sealing, prevents
Aphid escapes.In 25 ± 1 DEG C of temperature, relative humidity 70%, photoperiod L：D=14：Raise in the artificial temperature case of 10h, each
Concentration is repeated 3 times, and with dipped 0.1% TritonX-100 aqueous solution for comparison.Dead borer population is checked, with little brush pen after 24h
Touching worm foot and feeler nonresponder is death.
Brown Planthopper assay method：Rice-stem dipping method according to village woods and Shen Jinliang introduction forever carries out toxicity test, even
The rice strain in tillering stage to the boot stage of stalwartness of eradicating out, cleans, is cut into about 10cm long band root rice stem, 3 plants one group, dries in the air in the moon place of drying in the air
Dry；With distilled water by medicament by etc. ratio be serially diluted 5-6 concentration, then by rice stem respectively in the medicinal liquid of variable concentrations soak
30s, using distilled water as comparison, each concentration is repeated 3 times, and takes out after drying, encases root with the absorbent cotton soaking and put into training
In foster cup, 3 consistent age mid-term nymphs of access standard, 15 every glass；After standing 1-2h, reject impaired individuals.Connect a training after worm
Foster cup is put into temperature and is 27 ± 1 DEG C, and the photoperiod is 16：8h(L：D raise in incubator).Check dead after chemicals treatment 96h
Borer population, is moved with fine, soft fur style of writing and is unable to coordination exercise as death standard after polypide.
Data processing：
Using POLO Plus computed in software toxicity regression formula.Calculating parameter includes：Slope b value and standard error, card square,
Degree of freedom, LC50Value and 95% confidence limit.
Co-toxicity evaluation methodology：
The lab screening of composite formula adopts the abundant co-toxicity coefficient method of Sun Yun：
Toxicity index (TI)=(LC of standard agent50The LC of/reagent agent50)×100
The actual toxicity index of mixture (the ATI)=alone LC of medicament A50The mixed LC of/medicament A with B50)×100
Mixture theoretical toxicity index (TTI)=TI (A) × a+TI (B) × b
a：Represent percentage composition in mixture for the medicament A；
b：Represent percentage composition in mixture for the medicament B.
Co-toxicity coefficient CTC=(mixture actual toxicity index ATI/ mixture theoretical toxicity index TTI) × 100
According to the regulation of the Institute for the Control of Agrochemicals of the Ministry of Agriculture,PRC, the criterion of mixture formula potentiation is：Co-toxicity coefficient more than 120 is
Potentiation；Co-toxicity coefficient 80-120, is summation action；Co-toxicity coefficient is less than 80, is antagonism.
The selection of optimum proportioning is with the co-toxicity coefficient of mixture and LC50(or LD50) to weigh, that is, be total to poison is value two indices
The higher and LC of number50(or LD50) value minimum (i.e. actual measurement toxicity index is maximum).
Experimental result is as follows：It is shown in Table 1 and 2
The toxicity test result to bean aphid for the single dose and mixture of table 1 trifluoro-benzene pyrimidine and ethiprole
The toxicity test result to Brown Planthopper for the single dose and mixture of table 2 trifluoro-benzene pyrimidine and butene-fipronil
Table 1 table 2 Toxicity Determination result shows, compares 1 in weight：60-40：In the range of 1, trifluoro-benzene pyrimidine and ethiprole
Mixture is all higher than 120 with butene-fipronil mixture to the co-toxicity coefficient of Brown Planthopper to bean aphid and trifluoro-benzene pyrimidine, all
Show potentiation, wherein in trifluoro-benzene pyrimidine and ethiprole or butene-fipronil weight than for 1：30～20：In the range of 1,
All show as obvious potentiation, in trifluoro-benzene pyrimidine and butene-fipronil weight than for 1：15～10：In the range of 1, potentiation
Effect becomes apparent from.Therefore, trifluoro-benzene pyrimidine and ethiprole or butene-fipronil compound and can reach effective preventing and treating bean aphid
And Brown Planthopper, reduce the purpose of single dose consumption, there is extremely strong Development volue.
For making the technical problem to be solved in the present invention, technical scheme and advantage clearer, compare 1 in weight：60～40：1
In the range of, build the embodiment that trifluoro-benzene pyrimidine is compounded with ethiprole and butene-fipronil, be described in detail, but the present invention is exhausted
It is not limited to these examples.
The Pesticidal combination of the present invention can be prepared into any one dosage form of suitable agricultural use with known method, than
Preferably dosage form is suspension seed-coating agent, wet seed dressing, fumicants, suspending agent, microcapsule suspending agent or water dispersion granule.All formula
Middle percentage ratio is all weight percentage.The processing technique of the various dosage form of the present composition is prior art, according to not sympathizing with
Condition can be varied from.
With reference to embodiment, present invention is described further.
First, trifluoro-benzene pyrimidine with Firponil compounded
Embodiment 1：24.4% trifluoro-benzene pyrimidine ethiprole suspending agent (1：60)
Trifluoro-benzene pyrimidine 0.4%, ethiprole 24%, agriculture breast 400#5%th, sodium lauryl sulphate 2%, sodium lignin sulfonate
5%th, silicone oil 1%, Polyethylene Glycol 2%, sodium carboxymethyl cellulose 5%, deionized water supply 100%.By above raw material routinely
The method preparing suspending agent is mixed to prepare 24.4% trifluoro-benzene pyrimidine ethiprole suspending agent.
Embodiment 2：44% trifluoro-benzene pyrimidine ethiprole suspension seed-coating agent (1：43)
Trifluoro-benzene pyrimidine 1%, ethiprole 43%, film former 3%, wetting agent 2%, thickening agent 0.5%, warning coloration 0.5%,
Filler supplies 100%.The method that above raw material is routinely prepared suspension seed-coating agent is mixed to prepare 44% trifluoro-benzene pyrimidine fluorine
Worm nitrile suspension seed-coating agent.
Embodiment 3：15.5% trifluoro-benzene pyrimidine ethiprole water dispersible granules (1：30)
Trifluoro-benzene pyrimidine 0.5%, ethiprole 15%, wetting and penetrating agent (F) 4%, sodium lignin sulfonate 4%, bentonite
2%th, Kaolin supplies 100%.The method that above raw material is routinely prepared water dispersible granules is mixed to get 15.5% trifluoro-benzene
Pyrimidine ethiprole water dispersible granules.
Embodiment 4：20% trifluoro-benzene pyrimidine ethiprole suspending agent (1：19)
Trifluoro-benzene pyrimidine 1%, ethiprole 19%, agriculture breast 400#5%th, sodium lauryl sulphate 1%, sodium lignin sulfonate
4%th, silicone oil 0.5%, Polyethylene Glycol 1%, sodium carboxymethyl cellulose 1.2%, deionized water supply 100%.Above raw material is pressed
The method that dry suspending agent is formulated conventionally is mixed to prepare 20% trifluoro-benzene pyrimidine ethiprole suspending agent.
Embodiment 5：13% trifluoro-benzene pyrimidine ethiprole microcapsule suspending agent (1：5.5)
Trifluoro-benzene pyrimidine 2%, ethiprole 11%, cyst material polyvinyl acetate resin 5%, curing materials acrylamido
Sodium isopropyl xanthate 2%, dispersant 4%, emulsifying agent 0.5%, Polyethylene Glycol 1%, antifreeze 1.2%, deionized water are supplied
100%.Above raw material is routinely prepared microcapsule suspension agent method it is mixed to prepare 13% trifluoro-benzene pyrimidine ethiprole microcapsule and hang
Floating agent.
Embodiment 6：10% trifluoro-benzene pyrimidine ethiprole microcapsule suspending agent (1：1)
Trifluoro-benzene pyrimidine 5%, ethiprole 5%, cyst material polyvinyl acetate resin 4%, curing materials acrylamido
Sodium isopropyl xanthate 2%, dispersant 3%, emulsifying agent 0.5%, Polyethylene Glycol 1%, antifreeze 1.2%, deionized water are supplied
100%.Above raw material is routinely prepared microcapsule suspension agent method it is mixed to prepare 10% trifluoro-benzene pyrimidine ethiprole microcapsule and hang
Floating agent.
Embodiment 7：24% trifluoro-benzene pyrimidine ethiprole water dispersible granules (5：1)
Trifluoro-benzene pyrimidine 20%, ethiprole 4%, wetting and penetrating agent (F) 5%, sodium lignin sulfonate 4%, bentonite 2%,
Kaolin supplies 100%.The method that above raw material is routinely prepared water dispersible granules is mixed to prepare 24% trifluoro-benzene pyrimidine
Ethiprole water dispersible granules.
Embodiment 8：10.5% trifluoro-benzene pyrimidine ethiprole wettable powder (9.5：1)
Trifluoro-benzene pyrimidine 9.5%, ethiprole 1%, wetting and penetrating agent (F) 8%, sodium lignin sulfonate 10%, bentonite
10%th, Kaolin supplies 100%.The method that above raw material is routinely prepared wettable powder is mixed to prepare 10.5% trifluoro-benzene
Pyrimidine ethiprole wettable powder.
Embodiment 9：48% trifluoro-benzene pyrimidine ethiprole wet seed dressing (15：1)
Trifluoro-benzene pyrimidine 45%, ethiprole 3%, sodium lauryl sulphate 8%, sodium lignin sulfonate 5%, dispersant 2%,
Kaolin supplies 100%.Above raw material is routinely prepared the method mixing of wet seed dressing, be crushed to certain fineness, then through mixed
Even one-tenth product, obtains 48% trifluoro-benzene pyrimidine ethiprole wet seed dressing.
Embodiment 10：26% trifluoro-benzene pyrimidine ethiprole water dispersible granules (25：1)
Trifluoro-benzene pyrimidine 25%, ethiprole 1%, wetting and penetrating agent (F) 5%, sodium lignin sulfonate 4%, bentonite 2%,
Kaolin supplies 100%.The method that above raw material is routinely prepared water dispersible granules is mixed to prepare 26% trifluoro-benzene pyrimidine
Ethiprole water dispersible granules.
Embodiment 11：8.2% trifluoro-benzene pyrimidine ethiprole fumicants (40：1)
Trifluoro-benzene pyrimidine 8%, ethiprole 0.2%, oxidant 20%, smoke agent 20%, pilot agent 2%, fire retardant chemical 5%,
Adhesive 2%, wood flour supply 100%.It is phonetic that the method that above raw material is routinely prepared fumicants is mixed to get 8.2% trifluoro-benzene
Pyridine ethiprole fumicants.
2nd, trifluoro-benzene pyrimidine and butene-fipronil compound
Ethiprole in above example can mutually be replaced with butene-fipronil, to form new embodiment.To this no longer
Carry out repeating to enumerate it is noted that for those skilled in the art, without departing from principle of the present invention
On the premise of, some improvements and modifications can also be made, these improvements and modifications also should be regarded as protection scope of the present invention.
3rd, land for growing field crops application test
Carry out contrast experiment with embodiment and trifluoro-benzene pyrimidine, ethiprole, butene-fipronil single dose.With bean aphid, water
Brown plant-hopper, oil tea thorn giant coccid, sanitary insect pest flea are experimental subject, and wherein bean aphid is using seed dressing and two kinds of dispensers of spraying
Mode is prevented and treated, and Brown Planthopper, oil tea thorn giant coccid adopt spray pattern dispenser, occur Sheng phase beginning to carry out dispenser with insect pest,
Dispenser 1 time altogether, before dispenser, 3 days after dispenser, 7 days, investigates number of pest and calculates prevention effect for 14 days respectively, sanitary insect pest
Flea adopts fumicants fumigation control method.Prevention effect calculates as follows：
PT in formula0：Before dispenser, PT1：After dispenser, PT：Chemicals treatment district, CK：Blank district.
Result of the test see table：
Table 3 trifluoro-benzene pyrimidine and ethiprole/butene-fipronil single dose and compositionss are to bean aphid field seed dressing preventing and treating effect
Really
Note：Lowercase letter significant difference in 0.05 level, capitalization represents significant difference in 0.01 level.
(similarly hereinafter)
Table 4 trifluoro-benzene pyrimidine and ethiprole/butene-fipronil single dose and compositionss prevent and treat effect to bean aphid field spray
Really
Table 5 trifluoro-benzene pyrimidine and ethiprole/butene-fipronil single dose and compositionss are to Brown Planthopper field control effect
Table 6 trifluoro-benzene pyrimidine and ethiprole/butene-fipronil single dose and compositionss pierce giant coccid field control effect to oil tea
Table 7 trifluoro-benzene pyrimidine and ethiprole/butene-fipronil single dose and compositionss are to flea prevention effect
Table 3-7 test of pesticide effectiveness result shows, trifluoro-benzene pyrimidine and Phenylpyrazole insecticides ethiprole or butene-fipronil
Complex synergism substantially, compares 1 in weight：60-40：In the range of 1, particularly 1：30-20：In the range of 1, especially 1：15-
10：In the range of 1, bean aphid, Brown Planthopper, oil tea thorn giant coccid, sanitary insect pest flea prevention effect are all significantly better than
Single dose, reaches significant level.The present invention can be applied to other agriculturals, sanitary insect pest and mite class preventing and treating further in the same manner simultaneously, by
Limited in length, it is not repeated.
The above is the preferred embodiment of the present invention it is noted that for those skilled in the art
For, on the premise of without departing from principle of the present invention, some improvements and modifications can also be made, these improvements and modifications
Should be regarded as protection scope of the present invention.
Embodiment described above only have expressed the preferred embodiment of the present invention, and its description is more concrete and detailed, but simultaneously
Therefore the restriction to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, some deformation, improvement and replacement can also be made, these broadly fall into this
Bright protection domain.Therefore, the protection domain of patent of the present invention should be defined by claims.
Claims (9)
1. a kind of new and effective Pesticidal combination it is characterised in that：Comprise effective constituents A and B, effective constituents A is that trifluoro-benzene is phonetic
Pyridine, effective ingredient B is Phenylpyrazole insecticides ethiprole or butene-fipronil, the weight of described effective constituents A and effective ingredient B
Amount ratio is 1：60～40：1.
2. a kind of new and effective Pesticidal combination according to claim 1 it is characterised in that：Described effective constituents A with have
The weight ratio of effect composition B is for 1：30～20：1.
3. a kind of new and effective Pesticidal combination according to claim 2 it is characterised in that：Described effective constituents A with have
The weight ratio of effect composition B is for 1：15～10：1.
4. a kind of new and effective Pesticidal combination according to claim 1 or 2 or 3 it is characterised in that：Described Insecticidal combinations
Pesticidal preparations auxiliary element is also contained, to make the dosage form being suitable for use in thing.
5. a kind of new and effective Pesticidal combination according to claim 4, its feature exists：Described pesticidal preparations auxiliary element
For at least one in solvent, emulsifying agent, dispersant, stabilizer, antifreezing agent, wetting agent.
6. a kind of new and effective Pesticidal combination according to claim 4 it is characterised in that：The agent of described Pesticidal combination
Type is suspension seed-coating agent, wet seed dressing, fumicants, suspending agent, microcapsule suspending agent, wettable powder, water dispersion granule.
7. a kind of new and effective Pesticidal combination described in any one of claim 1-6 application it is characterised in that：Described parasite killing
Compositionss are applied to prevent and treat insect pest of the plant and sanitary insect pest.
8. a kind of new and effective Pesticidal combination described in claim 7 application it is characterised in that：Described Pesticidal combination should
For controlling sucking insects.
9. a kind of new and effective Pesticidal combination described in claim 7 or 8 application it is characterised in that：Described Insecticidal combinations
Thing be applied to anti-eliminate aphis, planthopper, a red-spotted lizard, flea, in the pesticidal preparations of louse.
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Cited By (1)
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| CN107156153A (en) * | 2017-06-30 | 2017-09-15 | 江苏省绿盾植保农药实验有限公司 | A kind of application of seed treatment of containing chlorine fluorine cyanogen insect amide in preventing and treating rice grub |
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| CN102665415A (en) * | 2009-08-05 | 2012-09-12 | 杜邦公司 | Mixtures of mesoionic pesticides |
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| CN105519551A (en) * | 2016-01-27 | 2016-04-27 | 江西省农业科学院植物保护研究所 | Efficient compound pesticide composition containing trifluoro-benzene pyrimidine |
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