CN106455969A - Eye imaging apparatus and systems - Google Patents

Abstract

Various embodiments disclose an eye imaging device. In some embodiments, the eye imaging device may include a light source, an image sensor, a handheld computing device, and an adapter module. The adapter module includes a microcontroller and a signal processor configured to adapt to the handheld computing device to control the light source and the image sensor. In some embodiments, the eye imaging device may include an external imaging module for imaging the anterior segment of the eye, and/or an anterior segment imaging module for imaging the posterior segment of the eye. The eye imaging device can be applied to an eye imaging medical system. Images of the eye can be captured by the eye imaging device, transmitted to an image computing module, stored in an image storage module, and displayed on a viewing module.

Description

Eye Imaging Devices and Systems

technical field

Embodiments of the present invention relate generally to ocular imaging devices and systems, eg, hand-held ocular imaging devices and related systems.

Background technique

Eye imaging systems are becoming more important in eye exams. Early diagnosis of eye disease is often important for effective treatment and prevention of vision loss. In general, a comprehensive eye examination should include examination of the anterior segment of the eye (such as the cornea), examination of the posterior segment of the eye (such as the retina), and visual function tests.

Traditionally, slit-lamp imaging systems have been used to examine the cornea. However, slit lamp imaging systems may lack mobility, making it difficult for medical personnel to move the equipment within a hospital and/or over long distances. For example, a cart carrying a slit lamp imaging system can be relatively heavy and difficult to move. A computer or console, and other system accessories associated with the system can reduce its portability within a hospital and can reduce the ability to move the system to remote rural areas. A retinal exam is usually done with another sophisticated eye imaging device. Switching between multiple eye imaging systems can be inconvenient and time consuming for the patient. Further, today's eye exams are often performed using a localized, self-contained imaging device. It can therefore be difficult to transfer medical data between different geographic locations and different hospitals. The problem of medical data transmission can be even more acute for some hospitals in developing countries or places where eye care is limited.

Contents of the invention

Various embodiments disclosed herein include an eye imaging device that includes a housing, a light source configured to illuminate the eye, and an image sensor configured to receive images of the eye. The light source and image sensor are inside the housing. For example, the light source and image sensor may be disposed inside the housing, or the light source and imaging sensor may be disposed on an external portion of the housing. The imaging device may also include a computing and communication unit within the housing that includes a handheld computing device configured to receive and transmit images. The imaging device may also include an adapter module inside the housing, which includes a microcontroller and a signal processing unit. The adaptation module is configured to adapt the handheld computing device to control the light source and image sensor.

For example, various embodiments may include an imaging device that includes a housing, within the housing a front imaging module that includes a light source configured to illuminate an eye, and an optical imaging system. The optical imaging system may include an optical window at a front end of the housing; the optical window has a front concave surface for receiving an eye. The imaging device may also include a main module within the housing including an imaging sensor configured to receive an image of the eye from the optical imaging system. The imaging system may also include a handheld computing device configured to accept and transmit images. The imaging device may also include an adapter module within the housing, which includes a microcontroller and a signal processing unit. The adaptation module is configured to adapt the handheld computing device to control the light source and image sensor.

Various embodiments also include an imaging device that includes a housing and an external imaging module, such as an anterior segment of the eye imaging module. The external imaging module includes an illumination unit including a light source configured to illuminate the eye, and an image sensor configured to receive an image of the eye. The external imaging module is positioned on an external portion of the housing. The imaging device may also include a handheld computing device and an adaptation module. The adaptation module includes a microcontroller and a signal processing unit, allowing the handheld imaging device to control the light source and image sensor.

In various embodiments, a handheld eye imaging device includes a housing and an external imaging module positioned outside the housing. The external imaging module includes a first lighting unit including a first light source for illuminating an eye, and a second lighting unit including a second light source for illuminating an eye. The external imaging module also includes a miniature camera. The miniature camera includes an image sensor configured to receive an image of the eye, and at least one lens positioned between the eye and the image sensor. The image sensor is placed between the first lighting unit and the second lighting unit. The first optical axis of the first lighting unit and the second optical axis of the second lighting unit converge on the optical axis of the micro camera. The external imaging module is configured to image the anterior segment of the eye.

In some embodiments, a handheld eye imaging device includes a housing and an external imaging module positioned on an outer portion of the housing. The external imaging module may include a first lighting unit including a first light source for illuminating the eye, and a special optical element located in front of the first light source configured to generate a focused light beam. The external imaging system may also include a miniature camera. The miniature camera may include an image sensor configured to receive an image of the eye. The first lighting unit is placed near the image sensor, and the distance between them is smaller than the size of the image sensor itself. The miniature camera may also include at least one lens located between the eye and the image sensor. The focused beam has a beam waist positioned less than 5 mm from the optical axis of the micro-camera. The external imaging module is configured to image the anterior segment of the eye.

In other embodiments, a handheld eye imaging device includes a housing and an external imaging module disposed on an outer portion of the housing. The external imaging module may include a first lighting unit including a first light source configured to generate a diverging light beam. The external imaging module may also include a miniature camera. The miniature camera may include an image sensor configured to receive an image of the eye. The first lighting unit is placed near the image sensor, and the distance between them is smaller than the size of the image sensor itself. The miniature camera may also include a lens positioned between the eye and the image sensor. The first optical axis of the first lighting unit is almost parallel to the optical axis of the miniature camera. The external imaging module is configured to image the anterior segment of the eye.

Various embodiments disclose a stereoscopic handheld eye imaging device. The stereoscopic handheld eye imaging device includes a housing and an external imaging module located at an outer portion of the housing. The external imaging module includes a first lighting unit including a first light source, and a second lighting unit including a second light source. In addition to the first micro-camera including the first image sensor, the external imaging module further includes a second micro-camera including a second image sensor. The first image sensor and the second image sensor are placed between the first lighting unit and the second lighting unit. The first optical axis of the first micro-camera and the second optical axis of the second micro-camera converge at a convergence angle.

In some embodiments, a stereoscopic handheld eye imaging device includes a housing and an external imaging module positioned on an outer portion of the housing. The external imaging module includes a first lighting unit including a first light source. In addition to the first micro-camera including the first image sensor, the external imaging module also includes a second micro-camera including a second image sensor. The first image processor is placed near the first lighting unit at a first distance and less than 10 mm from the first distance, and the second image sensor is placed near the first lighting unit at a second distance and at a second distance less than 10mm. The first optical axis of the first micro-camera and the second optical axis of the second micro-camera converge at a convergence angle. The first lighting unit may be configured to generate a focused beam or a diverging beam.

In various implementations, a handheld eye imaging device configured to image an anterior segment of an eye and a posterior segment of an eye is disclosed. The imaging device includes a housing, a front imaging module located within the housing, and an external imaging module located at an outer portion of the housing. The anterior imaging module includes a posterior light source configured to illuminate a posterior portion of the eye, and a posterior optical imaging system including an optical window at the forward end of the housing, the optical window having a concave anterior surface for receiving the eye. Also included within the housing is a posterior segment image sensor for receiving images of the posterior segment of the eye. The external imaging module includes a first anterior illumination unit including an anterior light source for illuminating an anterior portion of the eye, and a miniature camera including an anterior image sensor configured to receive images from the anterior portion of the eye.

Various embodiments also disclose a consumable package for an eye imaging device. In some embodiments, the consumable kit includes a vial with a back cap, an optically index-matched gel within the vial, and an alcohol tablet. The small tube is placed behind the at least one alcohol tablet, and the small tube is configured to eject the at least one alcohol tablet after the consumable pack is opened. In other embodiments, the consumable kit includes a cup with a tightened rim. The size of the cup matches the contour of the front end of the housing. A disinfectant and alcohol tablet are also included in the consumable pack. The disinfectant is placed in a sealed package. The sanitizing agent is configured to be released in the cup after the seal is removed.

In various implementations, an eye imaging medical system is disclosed that includes an eye imaging device. The eye imaging device includes a housing, a light source, and an image sensor for receiving an image of the eye. The light source and the image sensor are connected with the casing. The apparatus also includes a handheld computing device configured to receive and transmit images. The eye imaging device also includes an adaptation module within the housing that includes a microcontroller and a signal processing unit. The adaptation module is configured to adapt the handheld computing device to control the light source and image sensor. The eye imaging medical system further includes an image calculation module, which is configured to receive images from the eye imaging device and perform data interaction with the eye imaging device; includes an image storage module, which includes a database, and is configured to store images; also includes The review module, which includes a display screen, is configured to display images.

In other embodiments, an eye imaging medical system includes an eye imaging device including a housing and an external imaging module configured to form an image of an anterior segment of the eye. The external imaging system includes a first lighting unit including a first light source for illuminating an eye; a second lighting unit including a second light source for illuminating an eye; and a miniature camera. The miniature camera includes an image sensor configured to receive an image of the eye, and at least one lens positioned between the eye and the image sensor. The image sensor is placed between the first lighting unit and the second lighting unit. The first optical axis of the first lighting unit and the second optical axis of the second lighting unit converge on the optical axis of the micro camera. The eye imaging device also includes a computing and communication unit within the housing configured to receive and transmit images. The eye imaging medical system further includes an image computing module configured to accept images from the eye imaging device and perform data interaction with the eye imaging device; includes an image storage module including a database configured to store the the image; and a review module including a display configured to display the image.

In some additional embodiments, an eye imaging medical system includes an eye imaging device including a housing, an anterior segment imaging module for imaging a posterior segment of an eye, and an external imaging module for imaging an anterior segment of an eye. The front segment imaging module includes a rear segment light source; includes a rear segment optical imaging system, which includes an optical window located at the front end of the housing, and the optical window has a front concave surface for receiving eyes; includes a rear segment image sensor located in the housing, which Set to receive images of the posterior segment of the eye. The external imaging module includes a first anterior lighting unit comprising a first anterior light source for illuminating the anterior portion of the eye; comprising a miniature camera comprising an anterior image sensor arranged to receive images from the anterior eye; and comprising A computing communication unit within the housing configured to accept and transmit the image. The eye imaging medical system also includes an image calculation module configured to receive images from the eye imaging device and perform data interaction with the eye imaging device; includes an image storage module, which includes a database, configured to store the an image; and including a review module including a display configured to display the image.

Various embodiments also disclose a method for eye imaging. The method includes forming an image of the eye by illuminating the eye with a light source, receiving the image by using an image sensor, controlling the light source and the image sensor by using a handheld computing device through an adaptation module, and receiving and transmitting the image by using the handheld computing device the image.

In some embodiments, a method of imaging an anterior segment of an eye is disclosed. The method includes illuminating an anterior segment of the eye by a first lighting unit including a first light source and a second lighting unit including a second light source, receiving an image of the anterior segment of the eye by using an image sensor, wherein the image sensor is placed at the second between the first lighting unit and the second lighting unit. The method also includes controlling the first light source, the second light source, and the image sensor by using a handheld computing device, and receiving and transmitting the image by using the handheld computing device.

Various embodiments disclose methods of eye imaging using an eye imaging medical system. The method includes imaging the anterior and posterior segments of the eye by use of a handheld ocular imaging device. Using the handheld eye imaging device includes illuminating a posterior portion of the eye using a first light source within the housing, receiving a first image of the posterior portion using a first image sensor, illuminating an anterior portion of the eye using a second light source, using A second image sensor receives a second image of the anterior portion of the eye, and a handheld computing device within the housing is used to control the first and second light sources and first and second sensors, and the handheld computing device is used to receive and transmit the Describe the first and second images. The method also includes transmitting the first and second images to an image calculation module, storing the first and second images in an image storage module with a database, and on a review module including a larger display screen Display the first and second images.

Various embodiments include a handheld eye imaging device that is compact and portable to remote rural areas. The handheld eye imaging device utilizes the advanced capabilities of wireless data transmission and the high-speed computing capabilities of handheld computing devices. The handheld eye imaging device is capable of imaging both the anterior segment of the eye and the posterior segment of the eye. Moreover, the hand-held eye imaging device can also be connected with an ultrasound probe. The multifunctional handheld eye imaging device can use miniature cameras and solid state lighting technology to achieve high imaging performance and significant size reduction.

The handheld eye imaging device may be used in an eye imaging medical system. The hand-held eye imaging system in a small suitcase can be carried to remote rural areas with a little training by the user. By using the handheld eye imaging device, pictures of a patient's eye can be taken, including pictures of the anterior and posterior segments of the eye. The captured images can be sent to the image calculation module, stored in the image storage module, and displayed on the review module. These images can be reviewed by trained medical professionals through the eye imaging medical system at more convenient locations such as urban hospitals or large eye care clinics.

Various embodiments disclosed herein include:

Embodiment 1. An eye imaging device comprising:

a light source configured to illuminate the eye;

an image sensor configured to receive an image of the eye;

a computing and communication unit comprising a mobile computing device configured to receive and transmit said image; and

An adaptation module configured to adapt the improved mobile computing device to control the light source and image sensor.

Embodiment 2. The eye imaging device of embodiment 1, wherein said improved mobile computing device comprises a modified handheld computing device.

Embodiment 3. The eye imaging device of embodiment 2, wherein the modified mobile computing device is a modified smartphone.

Embodiment 4. The eye imaging device of embodiment 2, wherein the signal processing unit includes instructions to convert signals from the image processor and light source to one of the input/output ports of the handheld computing device. and converting a signal from one of the input/output ports of the handheld computing device to a data format recognizable by the image sensor and light source.

Embodiment 5. The eye imaging device in Embodiment 1 further includes a main control button, wherein the main control button includes a multi-function and multi-turn button, wherein the main control button includes an electric switch, so that through the adaptation A module controls the light source and image sensor.

Embodiment 6. The eye imaging device of embodiment 2, further comprising at least one lens positioned between the eye and the image sensor, wherein the lens is movable by an actuator, and wherein the adaptation module is further configured An actuator for adapting the handheld computing device to control the lens.

Embodiment 7. The eye imaging device described in Embodiment 6, wherein the signal processing unit includes instructions to convert a signal from at least one of the image sensor, light source, and lens actuator into the hand-held a data format recognized by one of the input/output ports of the computing device, and converting a signal from one of the input/output ports of the handheld computing device into at least one of the actuators of the image sensor, light source, and lens One of the recognized data formats.

Embodiment 8. The eye imaging device described in Embodiment 6 further includes a main control button, the main control button includes a multi-functional and multi-directional button, and the main control button includes an electric switch, so that through the adapter module Actuators that control the light source, image sensor and lens.

Embodiment 9. The eye imaging device of embodiment 1, further comprising a driving module configured to drive the light source.

Embodiment 10. The eye imaging device of Embodiment 1, further comprising a multiplexing module.

Embodiment 11. The eye imaging device of embodiment 2, further comprising at least one control button exposed from the handheld computing device and configured to be operated by mechanical transmission.

Embodiment 12. The eye imaging device of embodiment 1, wherein the computing and communication unit is configured to receive and transmit images via a wired communication system.

Embodiment 13. The eye imaging device of embodiment 1, wherein the computing and communication unit is configured to receive and transmit images via a wireless communication system.

Embodiment 14. The eye imaging device of embodiment 1, wherein the eye imaging device is configured to be battery powered.

Embodiment 15. The eye imaging device described in Embodiment 3, the improved smartphone includes at least one of the following: a low-power CPU, an image processor, an operating system, a touch screen display, a microphone, a speaker, and a wireless connection module .

Embodiment 16. The eye imaging device of embodiment 1, wherein the image comprises a video stream.

Embodiment 17. The eye imaging device of embodiment 1, wherein the light source, image sensor, and adaptation module are disposed within a housing.

Embodiment 18. The eye imaging device of embodiment 1, wherein the light source and image sensor are disposed on an outer portion of the housing.

Embodiment 19. An eye imaging device comprising:

Anterior imaging module, including:

a light source configured to illuminate the eye;

An optical imaging system comprising:

an optical window at the forward end of the housing having a front concave surface for receiving the eye; and

The main modules include:

an image sensor arranged to receive an image of the eye from said optical imaging system,

a computing and communication unit comprising an improved mobile computing device configured to receive and transmit images; and

An adaptation module configured to adapt the improved mobile computing device to control the light source and image sensor.

Embodiment 20. The eye imaging device of embodiment 19, wherein the improved mobile computing device is a handheld computing device.

Embodiment 21. The eye imaging device of embodiment 20, wherein the modified mobile computing device is a modified smartphone.

Embodiment 22. The eye imaging device of embodiment 19, wherein said adaptation module includes instructions to convert a signal from at least one of said image sensor and light source to one of the inputs/outputs of said improved mobile computing device and converting a signal from one of the output/input ports of the improved mobile computing device into a data format recognizable by at least one of the image sensor and light source.

Embodiment 23. The eye imaging device of Embodiment 19, further comprising a main control button, wherein the main control button comprises a multi-functional and multi-directional button, wherein the main control button comprises an electrical switch, whereby through the adaptive A matching module controls the light source and image sensor.

Embodiment 24. The eye imaging device of embodiment 19, further comprising at least one lens positioned between the eye and the image sensor, wherein the at least one lens is movable by an actuator, and wherein the adaptation module is further configured to The improved mobile computing device is adapted to control an actuator of a lens.

Embodiment 25. The eye imaging device of Embodiment 24, wherein the adaptation module includes instructions for converting the signal from at least one of the image sensor, light source, and lens actuator into a signal that can be read by the a data format recognized by an input/output port of the improved mobile computing device; and converting a signal from one of the input/output ports of the improved mobile computing device into actuating A data format recognized by at least one of the drives.

Embodiment 26. The eye imaging device of Embodiment 24, further comprising a main control button, wherein the main control button includes a multi-function and multi-directional button, wherein the main control button includes an electrical switch to pass through the adapter module Actuators that control the light source, image sensor, and lens.

Embodiment 27. The eye imaging device of embodiment 19, further comprising a driving module configured to drive the light source.

Embodiment 28. The eye imaging device of Embodiment 19, further comprising a multiplexing module.

Embodiment 29. The eye imaging device of Embodiment 19, further comprising at least one control button exposed from the improved mobile computing device configured to operate by mechanical transmission.

Embodiment 30. The eye imaging device of embodiment 19, wherein the anterior imaging module can be repeatedly attached and removed from the main module.

Embodiment 31. The eye imaging device of Embodiment 30, wherein the eye imaging device further comprises a locking ring interposed between the anterior segment imaging module and the main module.

Embodiment 32. The eye imaging device of Embodiment 19, wherein the anterior segment imaging module is configured to be replaced by an ultrasound probe.

Embodiment 33. The eye imaging device of Embodiment 19, wherein the improved mobile computing device is mounted on the top of the housing, wherein the front imaging module is mounted on the other side of the housing, and the optical window is in bottom of the case.

Embodiment 34. The eye imaging device of embodiment 19, wherein the improved mobile computing device is mounted at an oblique angle to the optical axis of the optical imaging system.

Embodiment 35. The eye imaging device of embodiment 19, wherein the improved mobile computing device is mounted substantially perpendicular to the optical axis of the optical imaging system.

Embodiment 36. The eye imaging device of embodiment 19, wherein the improved mobile computing device is mounted substantially parallel to the optical axis of the optical imaging system.

Embodiment 37. The eye imaging device of Embodiment 19, wherein the eye imaging device is configured to receive and transmit images via a wired communication system.

Embodiment 38. The eye imaging device of Embodiment 19, wherein the eye imaging device is configured to receive and transmit images via a wireless communication system.

Embodiment 39. The eye imaging device of Embodiment 19, wherein the eye imaging device is configured to be battery powered.

Embodiment 40. The eye imaging device of embodiment 19, wherein the eye imaging device further comprises a power receiver unit configured to receive power without a cable connection.

Embodiment 41. The eye imaging device of Embodiment 19, wherein the improved mobile computing device includes at least one of the following: a low power central processing unit, an image processing unit, an operating system, a touch screen display, a microphone, a speaker, and a wireless Connect the modules.

Embodiment 42. The eye imaging device of Embodiment 19, wherein the image comprises a video stream.

Embodiment 43. The ocular imaging device of embodiment 19, comprising a housing having a cylindrical portion and a cuboidal portion.

Embodiment 44. The eye imaging device of Embodiment 43, further comprising a rubber ring with raised nubs, wherein the handle rubber ring is disposed along the cylindrical portion of the housing, wherein the raised nubs are configured to Conforms to the user's palm.

Embodiment 45. The eye imaging device of Embodiment 19, further comprising a second imaging module comprising a second light source, a second image sensor, wherein the second image sensor is configured to receive a second image of the eye, wherein the The adaptation module is further configured to adapt the improved mobile computing device to control the second light source and the second image sensor.

Embodiment 46. An eye imaging device comprising:

shell;

external imaging modules, including

a lighting unit comprising a light source configured to illuminate an eye;

an image sensor configured to receive an image of the eye;

wherein the external imaging device is disposed on an external portion of the housing; and

The main module inside the housing consists of

computing and communication units, including improved mobile computing devices configured to receive and transmit images; and

an adaptation module located within the housing, wherein the adaptation module is configured to adapt the handheld computing device to control the light source and image sensor.

Embodiment 47. The eye imaging device of Embodiment 46, wherein the improved mobile computing device comprises a modified handheld computing device.

Embodiment 48. The eye imaging device of embodiment 46, wherein the improved mobile computing device comprises a modified smartphone.

Embodiment 49. The eye imaging device of Embodiment 46, wherein the adaptation module includes instructions to convert a signal from at least one of the image sensor and light source into one of the inputs of the improved mobile computing device A data format recognizable to the \output port, and converting a signal from one of the input\output ports of the improved mobile computing device into a data format recognizable by the light source and image sensor.

Embodiment 50. The eye imaging device of Embodiment 46, further comprising a main control button, wherein the main control button includes a multi-function and multi-directional button, wherein the main control button includes an electrical switch to pass through the adapter module The light source and image sensor are controlled.

Embodiment 51. The eye imaging device of Embodiment 46, further comprising at least one lens positioned between the eye and the image sensor, wherein the lens is movable by an actuator; wherein the adaptation module is further configured to adapt The improved mobile computing device is configured to control the lens actuator.

Embodiment 52. The eye imaging device of Embodiment 51, wherein the adaptation module includes a signal processing unit including instructions to convert signals from at least one of the image sensor, light source, and lens actuator to Convert to a data format recognizable by one of the input/output ports of the improved mobile computing device, and convert the signal sent by one of the input/output ports of the improved mobile computing device into the light source, image sensor and a data format recognizable by at least one of the lens actuators.

Embodiment 53. The eye imaging device according to Embodiment 51, further comprising a main control button, wherein the main control button includes a multi-functional and multi-directional button disposed on the casing, wherein the main control button includes an electric switch to pass through The adaptation module controls actuators of the light source, image sensor and lens.

Embodiment 54. The eye imaging device of Embodiment 46, further comprising a drive module within the housing configured to drive the light source.

Embodiment 55. The eye imaging device of Embodiment 46, further comprising a multiplexing module located inside the housing.

Embodiment 56. The eye imaging device of Embodiment 46, further comprising at least one control button exposed from the improved mobile computing device configured to be operated by mechanical transmission.

Embodiment 57. The eye imaging device of Embodiment 46, wherein the eye imaging device is configured to receive and transmit images via a wired communication system.

Embodiment 58. The eye imaging device of Embodiment 46, wherein the eye imaging device is configured to receive and transmit images via a wireless communication system.

Embodiment 59. The eye imaging device of Embodiment 46, wherein the eye imaging device is configured to be powered by a battery.

Embodiment 60. The eye imaging device of embodiment 46, wherein the improved mobile computing device includes at least one of the following: a low power central processing unit, a graphics processor, an operating system, a touch screen display, a microphone, a speaker, and wireless connectivity modules.

Embodiment 61. The eye imaging device of embodiment 46, wherein the image comprises a video stream.

Embodiment 62. The eye imaging device of Embodiment 46, further comprising a front imaging module including a second light source and an optical window at the front with a front concave surface for receiving the eye, wherein the main module further includes a second an image sensor, wherein the second image sensor is configured to receive a second image of an eye, wherein the adaptation module is further configured to adapt the improved mobile computing device to control the second light source and the second image sensor.

Embodiment 63 A handheld eye imaging device comprising:

The anterior segment imaging module includes

a first lighting unit including a first light source for illuminating eyes;

a second lighting unit including a second light source for illuminating eyes;

Micro cameras, including:

an image sensor configured to receive an image of the eye; and

at least one lens positioned between the eye and the image sensor;

Wherein the image sensor is located between the first lighting unit and the second lighting unit, wherein the first optical axis of the first lighting unit and the second optical axis of the second lighting unit converge on the optical axis of the miniature camera .

The anterior segment of the eye imaging module described therein is configured to image the anterior segment of the eye.

Embodiment 64. The handheld eye imaging device of Embodiment 63, wherein the image sensor is positioned a first distance from the first lighting unit and a second distance from the second lighting unit , where the first distance is equal to the second distance.

Embodiment 65. The handheld eye imaging device of Embodiment 63, wherein the first light source comprises a first light emitting element and the second light source comprises a second light emitting element.

Embodiment 66. The handheld eye imaging device of Embodiment 63, wherein the first illumination unit is configured to emit a first divergent beam of light, and the second illumination unit is configured to emit a second divergent beam of light.

Embodiment 67. The handheld eye imaging device of Embodiment 63, wherein the light emitted by the first and second light sources is in a narrowband spectral range.

Embodiment 68. The handheld eye imaging device of Embodiment 63, wherein the light emitted by the first and second light sources is in a broadband spectral range.

Embodiment 69. The first divergent beam handheld eye imaging device of Embodiment 63, wherein the light emitted by the first and second light sources is in the visible spectrum.

Embodiment 70. The handheld eye imaging device of Embodiment 63, wherein the light emitted by the first and second light sources is in the non-visible spectrum.

Embodiment 71. The hand-held eye imaging device of Embodiment 63, wherein said image sensor comprises a miniature sensor with a format no larger than about 1/2.2 inch or about 1/3.2 inch.

Embodiment 72. The handheld eye imaging device of Embodiment 63, wherein the image sensor detects light in the visible light spectrum.

Embodiment 73. The handheld eye imaging device of Embodiment 63, wherein the image sensor detects light in the non-visible light spectrum.

Embodiment 74. The handheld eye imaging device of Embodiment 63, wherein the handheld eye imaging device is configured to be battery powered.

Embodiment 75. The handheld eye imaging device of Embodiment 63, wherein the first and second illumination units are configured to be independently activated.

Embodiment 76. The hand-held eye imaging device of Embodiment 63, wherein the anterior segment of the eye imaging module further includes a third lighting unit that includes a third light source, the third lighting unit is located near the image sensor, and its two The distance between them is smaller than the size of the image sensor itself and is configured to produce a focused beam with a beam waist positioned less than 5 mm from the optical axis of the miniature camera.

Embodiment 77. The handheld eye imaging device of Embodiment 76, wherein the third light source comprises a third light emitting element.

Embodiment 78. The hand-held eye imaging device of Embodiment 76, wherein the anterior segment of the eye imaging module further includes a fourth illumination unit, which includes a fourth light source, and is disposed near the image sensor, with the distance between them The distance is smaller than the size of the image sensor itself, configured to produce a diverging beam.

Embodiment 79. The handheld eye imaging device of Embodiment 78, wherein the fourth light source comprises a fourth light emitting element.

Embodiment 80. The hand-held eye imaging device of Embodiment 63, wherein the anterior segment of the eye imaging module further includes a third lighting unit, which includes a third light source, located near the image sensor with a distance of less than The size of the image sensor itself, and is configured to produce a diverging beam.

Embodiment 81. The handheld eye imaging device of Embodiment 80, wherein the third light source comprises a third light emitting element.

Embodiment 82. The handheld eye imaging device of Embodiment 80, wherein the third light source emits light in the visible light spectrum.

Embodiment 83. The handheld eye imaging device of Embodiment 80, wherein the light emitted by the third light source is in the non-visible light spectrum.

Embodiment 84. The hand-held eye imaging device of Embodiment 63, further comprising an anterior imaging module configured to image a posterior segment of the eye, wherein the anterior imaging module includes a posterior light source, an anterior concave surface for receiving the eye An optical window, an imaging lens behind and optically aligned with the optical window, wherein the handheld imaging device further includes a second image sensor configured to receive a second image of the eye.

Embodiment 85. The hand-held eye imaging device of Embodiment 63, further comprising a main module comprising a computing and communication unit comprising a modified mobile computing device configured to receive and transmit images, and to adapt A module is configured to adapt said improved mobile computing device to control at least one of said first light source, second light source, and image sensor.

Embodiment 86 A handheld eye imaging device comprising:

Anterior segment imaging module, including:

A first lighting unit comprising

a first light source for illuminating the eyes; and

optics in front of the first light source configured to produce a focused beam of light;

and, miniature cameras, including

an image sensor configured to receive an image of an eye, wherein the first illumination unit is located adjacent to the image sensor at a distance smaller than the size of the image sensor itself; and

at least one lens positioned between the eye and the image sensor;

Wherein the beam waist of the focused beam is positioned less than about 5 mm from the optical axis of the micro-camera.

Wherein the anterior segment imaging module is configured to image the anterior segment of the eye.

Embodiment 87. The hand-held eye imaging device of Embodiment 86, wherein the image sensor comprises a miniature sensor with a format no larger than about 1.2/2 inches or about 1/3.2 inches.

Embodiment 88. The hand-held eye imaging device of Embodiment 86, wherein the image sensor operates in the frequency of light visible to the human eye.

Embodiment 89. The handheld eye imaging device of Embodiment 86, wherein the image sensor operates in the non-visible light spectrum of the human eye.

Embodiment 90. The handheld eye imaging device of Embodiment 86, wherein the handheld eye imaging device is configured to be battery powered.

Embodiment 91. The handheld eye imaging device of Embodiment 86, wherein the first light source comprises a first light emitting element.

Embodiment 92. The hand-held eye imaging device of Embodiment 86, wherein the anterior segment of the eye imaging module further comprises a second illumination unit comprising a second light source located near the image sensor with a distance of less than The size of the image sensor itself, wherein the second illumination unit is configured as a diverging light beam, wherein the second optical axis of the second illumination unit is substantially parallel to the optical axis of the micro camera.

Embodiment 93. The handheld eye imaging device of Embodiment 92, wherein the second light source comprises a second light emitting element.

Embodiment 94. The handheld eye imaging device of Embodiment 92, wherein the second light source emits light in the visible light spectrum.

Embodiment 95. The handheld eye imaging device of Embodiment 92, wherein the light emitted by the second light source is in the non-visible light spectrum.

Embodiment 96. The hand-held eye imaging device of Embodiment 86, further comprising an anterior segment imaging module configured to image a posterior segment of the eye, wherein the anterior segment imaging module comprises a posterior segment light source, has an anterior segment for receiving the eye A concave optical window, an imaging lens located behind the optical window and optically aligned with the optical window, wherein the handheld eye imaging device further includes a second image sensor for receiving a second image of the eye.

Embodiment 97 The hand-held eye imaging device of Embodiment 86, further comprising a main module within the housing that includes a computing and communication unit comprising a modified computing device configured to receive and transmit images, and an adaptation module configured to adapt the improved mobile computing device to control the first light source, the second light source, and the image sensor.

Embodiment 98 A handheld eye imaging device comprising:

The anterior segment imaging module includes:

A first lighting unit, comprising:

a first light source configured to generate a divergent light beam to illuminate the eye; and

Micro cameras, including:

an image sensor configured to receive an image of an eye, wherein the first illumination unit is located adjacent to the image sensor at a distance smaller than the size of the image sensor itself; and

at least one lens positioned between the eye and the image sensor;

wherein the first optical axis of the first lighting unit is substantially parallel to the optical axis of the micro camera;

Wherein the anterior segment of the eye imaging module is configured to image the anterior segment of the eye.

Embodiment 99 The hand-held eye imaging device of Embodiment 98, wherein the image sensor comprises a miniature sensor with a format no larger than about 1.2/2 inches or about 1/3.2 inches.

Embodiment 100. The handheld eye imaging device of Embodiment 98, wherein the image sensor detects light in the visible light spectrum.

Embodiment 101. The handheld eye imaging device of Embodiment 98, wherein the image sensor detects light in the non-visible light spectrum.

Embodiment 102. The handheld eye imaging device of Embodiment 98, wherein the handheld eye imaging device is configured to be battery powered.

Embodiment 103. The handheld eye imaging device of Embodiment 98, wherein the first light source comprises a first light emitting element.

Embodiment 104. The handheld eye imaging device of Embodiment 98, wherein the first light source emits light in the visible spectrum.

Embodiment 105. The handheld eye imaging device of Embodiment 98, wherein the first light source emits light in the non-visible spectrum.

Embodiment 106. The hand-held eye imaging device of Embodiment 98, further comprising an anterior segment imaging module configured to image a posterior segment of the eye, wherein the anterior segment imaging module comprises a posterior segment light source and has an anterior concave surface for receiving the eye an optical window, an imaging lens positioned behind the optical window and optically aligned with the optical window, wherein the handheld imaging device further includes a second image sensor within the housing configured to receive a second image of the eye.

Embodiment 107. The hand-held eye imaging device of Embodiment 98, further comprising a main module within said housing that includes a computing and communication unit comprising a modified mobile computing device configured to receive and transmitting an image; and including an adaptation module, wherein the adaptation module is configured to adapt the improved mobile computing device to control at least one of the first light source, second light source, and image sensor.

Embodiment 108. A stereoscopic handheld eye imaging device comprising:

Anterior segment imaging module, including:

a first lighting unit comprising a first light source for illuminating eyes;

a second lighting unit comprising a second light source for illuminating the eyes;

a first micro-camera including a first image sensor configured to receive a first image of the eye;

a second micro-camera comprising a second image sensor configured to receive a second image of the eye; wherein the first image sensor and the second image sensor are located between the first lighting unit and the second lighting unit,

Wherein the first optical axis of the first micro-camera and the second optical axis of the second micro-camera converge at a convergence angle, wherein the anterior segment of the eye imaging module is configured to image the anterior segment of the eye.

Embodiment 109. The stereoscopic handheld eye imaging device of Embodiment 108, wherein the first image sensor is a first distance from the first lighting unit and a second distance from the second lighting unit. distance, wherein the first distance and the second distance are substantially equal, and wherein the second image sensor is located adjacent to the first image sensor to provide stereoscopic imaging.

Embodiment 110. The stereoscopic handheld eye imaging device of Embodiment 109, wherein the first image sensor is optically aligned with the optical axis of the eye, and wherein the second image sensor is inclined to the optical axis.

Embodiment 111. The stereoscopic handheld eye imaging device of Embodiment 109, wherein the anterior segment of the eye imaging module further includes an optical element located in front of the second image sensor, wherein the optical element and the second image sensor The second optical axis and the first optical axis are parallel, wherein the optical element is configured to fold the second optical axis to form a converging angle with the first optical axis.

Embodiment 112. The stereoscopic handheld eye imaging device of Embodiment 108, wherein the first image sensor and the second image sensor are positioned symmetrically about the optical axis of the eye.

Embodiment 113. The stereoscopic handheld eye imaging device of Embodiment 108, wherein the anterior segment of the eye imaging module further includes an optical element located in front of the first image sensor and the second image sensor, wherein the first light axis and the second optical axis are parallel and have a certain distance between the optical element and the first and second image sensors, wherein the special optical element is configured to change the first optical axis and the The direction of the second optical axis is thus formed so as to form a convergence angle.

Embodiment 114. The stereoscopic handheld eye imaging device of Embodiment 108, wherein the first image sensor and the second image sensor are symmetrically tilted to form a convergence angle.

Embodiment 115. The stereoscopic handheld eye imaging device of Embodiment 108, wherein the first light source comprises a first light emitting element and the second light source comprises a second light emitting element.

Embodiment 116. The stereoscopic handheld eye imaging device of embodiment 108, wherein the angle of convergence is fixed.

Embodiment 117. The stereoscopic handheld eye imaging device of Embodiment 108, wherein the angle of convergence is adjustable.

Embodiment 118. The stereoscopic handheld eye imaging device of embodiment 108, wherein the angle of convergence is between 5 degrees and 13 degrees.

Embodiment 119. The stereoscopic hand-held eye imaging device of Embodiment 108, wherein the light emitted by the first and second light sources is within a narrowband spectral range.

Embodiment 120. The stereoscopic handheld eye imaging device of embodiment 108, wherein the light emitted by the first and second light sources is in a broadband spectral range.

Embodiment 121. The stereoscopic handheld eye imaging device of embodiment 108, wherein the first and second light sources emit light in the visible light spectrum.

Embodiment 122. The stereoscopic hand-held eye imaging device of Embodiment 108, wherein the light emitted by the first and second light sources is within the non-visible light spectrum.

Embodiment 123. The stereoscopic hand-held eye imaging device of Embodiment 108, wherein the first image sensor comprises a first microsensor having a format no larger than about 1/2.2 inch or about 1/3.2 inch, and wherein the first The second image sensor includes a second microsensor having a format no larger than about 1/2.2 inch or about 1/3.2 inch.

Embodiment 124. The stereoscopic handheld eye imaging device of embodiment 108, wherein the first and second image sensors detect light in the visible light spectrum.

Embodiment 125. The stereoscopic hand-held eye imaging device of Embodiment 108, wherein the first and second image sensors detect light in the non-visible light spectral range.

Embodiment 126. The stereoscopic handheld eye imaging device of Embodiment 108, wherein the handheld stereoscopic eye imaging device is configured to be powered by a battery.

Embodiment 127. The stereoscopic handheld eye imaging device of Embodiment 108, wherein the first and second illumination units are configured to be independently activated.

Embodiment 128. The stereoscopic handheld eye imaging device of Embodiment 108, wherein the anterior segment of the eye imaging module further includes a third lighting unit, which includes a third light source and an optical element, wherein the third lighting unit is positioned on the image Near the sensor, and the distance between the two is smaller than the size of the image sensor itself, wherein the optical element is configured to focus the beam with its beam waist positioned less than about 5 mm from the optical axis of the micro-camera.

Embodiment 129. The stereoscopic handheld eye imaging device of Embodiment 128, wherein the third light source comprises a third light emitting element.

Embodiment 130. The stereoscopic handheld eye imaging device of Embodiment 128, wherein the anterior segment of the eye imaging module further includes a fourth lighting unit, which includes a fourth light source, the fourth light source is located near the image sensor, and both The distance between them is smaller than the size of the image sensor, configured to generate a divergent light beam, wherein the fourth optical axis of the fourth lighting unit is substantially parallel to the optical axis of the micro camera.

Embodiment 131. The stereoscopic handheld eye imaging device of Embodiment 130, wherein said fourth light source comprises a fourth light emitting element.

Embodiment 132. The stereoscopic handheld eye imaging device of Embodiment 108, wherein the external imaging module further comprises a third illumination unit comprising a third light source located in the vicinity of the image sensor and both The distance between them is smaller than the size of the image sensor itself, and is configured to generate a diverging light beam, wherein the third optical axis of the third lighting unit is substantially parallel to the optical axis of the micro camera.

Embodiment 133. The stereoscopic handheld eye imaging device of Embodiment 132, wherein the third light source comprises a third light emitting element.

Embodiment 134. The stereoscopic handheld eye imaging device of Embodiment 132, wherein the light emitted by the third light source is in the visible light spectrum.

Embodiment 135. The stereoscopic handheld eye imaging device of Embodiment 132, wherein the light emitted by the third light source is in the non-visible light spectrum range.

Embodiment 136. The stereoscopic handheld eye imaging device of Embodiment 108, further comprising an anterior segment imaging module configured to image the posterior segment of the eye, wherein the anterior segment imaging module includes a posterior segment light source, has a An optical window on the front concave surface of the optical window, an imaging lens located behind the optical window and optically aligned with the optical window, wherein the handheld imaging device further includes a posterior segment image sensor configured to receive a posterior segment image of the eye.

Embodiment 137. The stereoscopic handheld eye imaging device of Embodiment 108, further comprising a main module comprising a computing and communication unit comprising a modified mobile computing device and configured to receive and transmit images, and An adaptation module configured to adapt the handheld computing device to control at least one of the first light source, second light source, first image sensor, and second image sensor.

Embodiment 138 A stereoscopic handheld eye imaging device comprising:

Imaging devices for the anterior segment of the eye include:

a first lighting unit comprising a first light source for illuminating eyes;

a first micro-camera including a first image sensor configured to receive a first image of an eye;

a second micro-camera including a second image sensor configured to receive a second image of the eye;

Wherein the first image sensor is located near the first lighting unit with a first distance between them less than 10 mm, and the second image sensor is located near the first lighting unit with a second distance between them The distance is less than 10mm,

Wherein the first optical axis of the first micro-camera and the second optical axis of the second micro-camera converge at a convergence angle.

Wherein the external imaging module is configured to image the anterior segment of the eye.

Embodiment 139. The stereoscopic handheld eye imaging device of Embodiment 138, wherein the first image sensor is optically aligned with the optical axis of the eye, and wherein the second image sensor is in close proximity to the first image sensor.

Embodiment 140. The stereoscopic hand-held eye imaging device of Embodiment 139, wherein the second image sensor is tilted with respect to the optical axis.

Embodiment 141 The stereoscopic handheld eye imaging device of Embodiment 139, wherein the external imaging module further comprises an optical element positioned in front of the second image sensor, wherein the optical element is configured to alter the second light axis so as to form a converging angle with said first optical axis.

Embodiment 142. The stereoscopic handheld eye imaging device of Embodiment 138, wherein the first and second image sensors are positioned symmetrically about the optical axis of the eye.

Embodiment 143. The stereoscopic handheld eye imaging device of Embodiment 142, wherein the anterior segment of the eye imaging module further comprises an optical element located in front of the first image sensor and the second image sensor, wherein the optical element is configured to change the directions of the first optical axis and the second optical axis to form a convergence angle.

Embodiment 144 The stereoscopic handheld eye imaging device of Embodiment 138, wherein said first image sensor and said second image sensor are symmetrically tilted to form a convergence angle.

Embodiment 145. The stereoscopic handheld eye imaging device of Embodiment 138, wherein the first illumination unit further comprises an optical element configured to generate a focused beam with a beam waist positioned less than about 5 mm from the optical axis of the eye place.

Embodiment 146. The stereoscopic handheld eye imaging device of Embodiment 138, wherein the first illumination unit is configured to generate a diverging light beam, wherein the first optical axis of the first illumination unit is substantially parallel to the optical axis of the eye .

Embodiment 147. The stereoscopic handheld eye imaging device of Embodiment 138, wherein the first light source comprises a first light emitting element.

Embodiment 148 The stereoscopic handheld eye imaging device of Embodiment 138, wherein the angle of convergence is fixed.

Embodiment 149 The stereoscopic handheld eye imaging device of Embodiment 138, wherein the angle of convergence is adjustable.

Embodiment 150. The stereoscopic handheld eye imaging device of embodiment 138, wherein the angle of convergence is between 5 degrees and 13 degrees.

Embodiment 151 The hand-held eye imaging device of Embodiment 138, wherein the first image sensor comprises a first microsensor having a format no larger than about 1/2.2 inch or about 1/3.2 inch, and wherein the second The image sensor includes a second microsensor having a format no larger than about 1/2.2 inch or about 1/3.2 inch.

Embodiment 152. The handheld eye imaging device of Embodiment 138, wherein the handheld eye imaging device is configured to be battery powered.

Embodiment 153 The hand-held eye imaging device of Embodiment 138, further comprising an anterior segment imaging module configured to image a posterior segment of the eye, wherein the anterior segment imaging module includes a posterior segment light source, has a An optical window on the front concave surface, an imaging lens placed behind the optical window and optically aligned with the optical window, wherein the stereoscopic handheld imaging device further includes a posterior segment imaging sensor configured to receive the posterior segment of the eye segment image.

Embodiment 154. The stereoscopic handheld eye imaging device of Embodiment 138, further comprising a main module within the housing that includes a computing and communication unit comprising a handheld computing device configured to receive and transmit images , and an adaptation module configured to adapt the handheld computing device to control at least one of the first light source, first image sensor, and second image sensor.

Embodiment 155 A handheld eye imaging device comprising:

Anterior segment imaging module, including:

a posterior segment light source configured to illuminate the posterior segment of the eye,

A rear segment optical imaging system, comprising:

an optical window having a front concave surface for receiving the eye;

an imaging lens positioned behind and optically aligned with the optical window;

a posterior segment image sensor configured to receive a posterior segment image from the posterior segment of the eye; and

Anterior segment imaging module, including:

a first front lighting unit comprising a first front light source for illuminating the front of the eyes; and

miniature camera, including

an anterior segment image sensor configured to receive an anterior segment image from an anterior segment of the eye; and

at least one lens located between the eye and the front image sensor.

Embodiment 156. The hand-held eye imaging device of Embodiment 155, wherein the anterior eye imaging module further comprises a second anterior lighting unit comprising a second anterior light source for illuminating the anterior eye, wherein the anterior image sensor It is arranged between the first front lighting unit and the second front lighting unit, wherein the first optical axis of the first front lighting unit and the second optical axis of the second front lighting unit are in the direction of the micro camera converge at the optical axis.

Embodiment 157. The hand-held eye imaging device of Embodiment 155, wherein the anterior eye imaging module further comprises an optical element, wherein the first anterior illumination unit is placed near and between the anterior image sensor The distance is less than the size of the front-end image sensor itself, wherein the optical elements are configured to generate a focused beam with a beam waist positioned less than about 5 mm from the optical axis of the micro-camera.

Embodiment 158. The hand-held eye imaging device of Embodiment 155, wherein the first front illumination unit is placed adjacent to the front image sensor at a distance smaller than the size of the front image sensor itself, wherein the The first front lighting unit is configured to generate a diverging light beam, wherein the first optical axis of the first front lighting unit is substantially parallel to the optical axis of the micro camera.

Embodiment 159 The handheld eye imaging device of Embodiment 155, wherein the handheld eye imaging device is configured to be battery powered.

Embodiment 160 The handheld eye imaging device of Embodiment 155, further comprising a main module comprising a computing and communication unit comprising a handheld computing device configured to receive and transmit images; and an adaptation module, It is configured to adapt the handheld computing device to control at least one of the rear light source, rear image sensor, first front light source, and front image sensor.

Embodiment 161. The handheld eye imaging device of Embodiment 160, wherein the handheld eye imaging device is configured to receive and transmit images wirelessly.

Embodiment 162 A lens cleaning device comprising:

One accessory includes:

A consumable kit comprising:

a small tube;

an optically index-matched gel within the vial; and

Alcohol tablets.

Embodiment 163 A lens cleaning device comprising:

A consumable kit comprising:

a cup with a screwed-on rim, wherein the cup is sized to match the contour of the front end of a hand-held camera;

a sanitizer in a sealed package, wherein the sanitizer is configured to be released into the cup; and

Alcohol tablets.

Embodiment 164 An eye imaging medical system comprising:

An eye imaging device comprising:

light source for illuminating the eyes;

an image sensor for receiving an image of the eye;

a computing and communication unit comprising an improved mobile computing device configured to receive and transmit images; and

an adaptation module configured to adapt the handheld computing device to control the light source and image sensor; and

an image computing module configured to accept and exchange data with images from the eye imaging system;

an image storage module, including a database, configured to store images; and

A review module, which includes a display, is configured to display images.

Embodiment 165. The eye imaging medical system of Embodiment 164, wherein the images are transmitted in real time between the eye imaging device, image calculation module, image storage module, and review module.

Embodiment 166 The eye imaging medical system of Embodiment 164, wherein the images are wirelessly transmitted between the handheld eye imaging device, image computation module, image storage module, and review module.

Embodiment 167. The eye imaging medical system of Embodiment 164, further comprising a carrying case, wherein the eye imaging device is placed within the carrying case.

Embodiment 168 The eye imaging medical system of Embodiment 167, wherein the carrying case has dimensions less than 600mm x 400mm x 300mm.

Embodiment 169 The eye imaging medical system of Embodiment 167, wherein the suitcase is placed on a shelf of a mobile cart on which the information input device is placed.

Embodiment 170. The eye imaging medical system of Embodiment 167, wherein said carrying case includes a plurality of areas for housing one or more of said eye imaging device, said image computing module, a power supply, a spare battery, and Supplies pack.

Embodiment 171 The eye imaging medical system of Embodiment 169, wherein the carrying case further comprises an area for placing a printer.

Embodiment 172. A kit comprising a consumable pack comprising a sufficient amount of an optically index-matched gel in a vial, and an alcohol sheet, wherein the vial is placed on at least one alcohol sheet rear of the device, wherein the small tube is configured to eject at least one alcohol tablet.

Embodiment 173 A kit comprising a consumable pack comprising a cup with a screw-on rim, wherein the cup is sized to match the profile of the camera front; comprising a sterile , in which the sanitizer is configured to be released into the cup; and includes alcohol tablets.

Embodiment 174. An eye imaging medical system comprising:

A handheld eye imaging device comprising:

Anterior segment imaging modules include:

a first lighting unit comprising a first light source for illuminating eyes;

a second lighting unit comprising a second light source for illuminating the eyes;

Micro cameras, including:

an image sensor configured to receive an image of the eye; and

at least one lens positioned between the eye and the image sensor;

Wherein, the image sensor is placed between the first lighting unit and the second lighting unit, wherein the first optical axis of the first lighting unit and the second optical axis of the second lighting unit are in the converge on the optical axis of the miniature camera;

Wherein the anterior segment of the eye imaging module is configured to image the anterior segment of the eye; and

a computing and communication unit configured to receive and transmit images; and

an image calculation module configured to receive images from the eye imaging device and exchange data with them;

an image storage module, including a database, configured to store images; and

A review module, including a display, is configured to display images.

Embodiment 175 An eye imaging medical system comprising:

A handheld eye imaging device comprising:

shell;

Anterior segment imaging module, including:

a light source configured to illuminate the eye;

An optical imaging system comprising:

an optical window with a front concave surface for receiving the eye; and

Main module, including:

an image sensor configured to receive an image of the eye from the optical imaging system; and

a computing and communication unit configured to receive and transmit images, and

an image computing module configured to receive and exchange data with images from the eye imaging device;

an image storage module, including a database, configured to store images; and,

A review module, including a display, is configured to display images.

Embodiment 176. An eye imaging medical system comprising:

A handheld eye imaging device comprising:

Anterior segment imaging module, including:

a posterior segment light source configured to illuminate the posterior segment of the eye,

A posterior segment optical imaging system comprising an optical window at the front segment of the housing having an anterior concave surface for receiving the eye;

a posterior segment image sensor configured to receive a posterior segment image from the posterior segment of the eye;

An anterior segment of the eye imaging module located on the outer portion of the housing, comprising:

The first front lighting unit includes a first front light source for illuminating the front of the eyes;

a miniature camera including an anterior segment image sensor configured to receive an anterior segment image from the anterior segment of the eye; and

a computing and communication unit within the housing configured to receive and transmit images, and

an image computing module configured to receive and exchange data with images from the eye imaging device;

an image storage module comprising a database configured to store images;

and a review module including a display screen configured to display an image.

Embodiment 177. A method of imaging an eye comprising

forming an image of the eye by illuminating the eye with a light source;

receiving said image by using an image sensor;

using a modified computing device through an adaptation module to control said light source and image sensor; and

Images are received and transmitted using the improved mobile computing device.

Embodiment 178. The method of imaging an eye of Embodiment 177, further comprising using the improved mobile computing device through an adaptation module to control an actuator of at least one lens.

Embodiment 179. The imaging method for the eye of Embodiment 177, further comprising converting the signal from at least one of the image sensor and the light source into the improved A data format recognizable by an input\output port in the mobile computing device, and converting a signal from an input\output port in the improved mobile computing device into a data format recognizable by at least one of the image sensor and the light source a data format.

Embodiment 180 A method of imaging the anterior segment of the eye comprising:

illuminating the front segment of the eye by a first lighting unit comprising a first light source and a second lighting unit comprising a second light source,

receiving an image of the anterior segment of the eye by using an image sensor, wherein the image sensor is positioned between the first lighting unit and the second lighting unit;

controlling said first light source, second light source and image sensor by using an improved mobile device; and

Images are received and transmitted using the improved mobile computing device.

Embodiment 181. The method of imaging the anterior segment of the eye of embodiment 180, further comprising illuminating the anterior segment of the eye with a third lighting unit comprising a third light source, wherein the third lighting unit is located near the image sensor and two The distance between them is smaller than the size of the image sensor itself, wherein the third illumination unit is configured to generate a focused beam with a beam waist less than about 5 mm from the optical axis of the eye.

Embodiment 182. The method for imaging the anterior segment of the eye in Embodiment 181, further comprising illuminating the anterior segment of the eye with a fourth lighting unit comprising a fourth light source, wherein the fourth lighting unit is located near the image sensor and two The distance between them is smaller than the size of the image sensor itself, wherein the fourth illumination unit is configured to generate a diverging light beam.

Embodiment 183. A method of eye imaging using an eye imaging medical system comprising:

Imaging of the anterior and posterior segments of the eye by using a hand-held eye imaging device, including

By illuminating the posterior segment of the eye using a first light source within the housing,

receiving a first image of the posterior segment of the eye using a first image sensor,

By illuminating the front segment of the eye with a second light source,

receiving a second image of the anterior segment of the eye using a second image sensor,

by using a modified handheld computing device to control said first and second light sources, and first and second image sensors,

receiving and transmitting the first and second images by using the improved handheld computing device;

transmitting the first and second images to an image computing module;

storing the first and second images in an image storage module having a database; and

The first and second images are displayed on a review module including a large display screen.

Description of drawings

Fig. 1 schematically shows a handheld eye imaging device according to various embodiments.

Fig. 2(A) schematically shows a perspective view of the handheld eye imaging device according to some embodiments, including a detachable anterior imaging module, a main module and a locking ring.

Fig. 2(B) schematically shows a side view of the handheld eye imaging device according to some embodiments, including a detachable anterior segment imaging module, main module and a locking ring.

FIG. 3(A) schematically shows additional details of the handheld eye imaging device, including a detachable anterior segment imaging module and a main module, according to various embodiments.

Fig. 3(B) schematically shows the optical imaging system of the handheld eye imaging device according to various embodiments, including a detachable front imaging module and a main module.

Fig. 3(C) schematically shows a block diagram of the eye imaging device, including an adaptation module.

FIG. 3(D) schematically shows a block diagram of the handheld eye imaging device, including a handheld computing device, according to various embodiments.

Figure 3(E) schematically shows a block diagram of the handheld eye imaging device, including the main control buttons interfaced with the adapter module, according to various embodiments.

Figure 4 schematically shows an external imaging module disposed on an external portion of the housing of an eye imaging device according to various embodiments.

Fig. 5 schematically shows a special lighting configuration of the external imaging module according to various embodiments.

Fig. 6(A) schematically shows the eye imaging device according to some embodiments, including a second miniature camera with a second image sensor for capturing stereoscopic images.

Fig. 6(B) schematically shows a special lighting system for the stereoscopic external imaging module.

Fig. 7(A) schematically shows another embodiment of a stereoscopic external imaging module.

Fig. 7(B) schematically shows an external imaging module with stereoscopic (3D) imaging according to some embodiments.

Figure 8(A) schematically shows the additional stereoscopic external imaging module according to some embodiments.

Fig. 8(B) schematically shows other stereoscopic external imaging modules according to some embodiments.

Fig. 9 schematically shows a consumable package of the handheld eye imaging device according to some embodiments.

Figure 10 schematically shows a consumable package of the eye imaging device according to some embodiments.

Figure 11 schematically shows a consumable pack of the hand-held eye imaging device for improved disinfection processing in accordance with some embodiments.

Fig. 12 schematically shows a networked eye imaging system including the handheld eye imaging device.

Figure 13 schematically shows a networked eye imaging system placed on a cart according to some embodiments.

14 is a schematic block diagram of the networked eye imaging system including the handheld eye imaging device, according to various embodiments.

detailed description

Referring now to the accompanying drawings, the present invention will be described in detail. This invention may be embodied in many different forms and should not be construed as limited to the exemplary embodiments discussed herein.

Fig. 1 schematically shows a handheld eye imaging device 100 according to various embodiments. For example, the eye imaging device 100 may comprise a housing comprising a cylindrical portion 111 and a cuboidal portion 112 . The cuboidal portion 112 may be mounted on top of the cylindrical portion 111 in some embodiments. The cylindrical portion 111 may have a tapered front end portion 116 which may be brought closer to the patient's eye during the examination. In some embodiments, the length of the cylindrical portion 111 may be between about 50 mm and 200 mm, and the diameter may be between about 20 mm and 80 mm. The cylindrical portion 111 may have a front portion 116 and a rear portion 118 . In some embodiments, the front portion 116 of the cylindrical portion 111 may be frusto-conical or truncated-conical, the length of which is about 10mm to 50mm, and the diameter of the front end 113 of the cylindrical portion 111 is about 5mm to 20mm. The rear portion 118 of the cylindrical portion 111 may be connected to the cuboidal portion 112 . The cube portion 112 may include a touch screen display 105 . In some embodiments, the cube portion 112 may have dimensions between about 50mm x 100mm and about 130mm x 200mm. The cubic part 112 may be mounted on the cylindrical part 111 at an angle. In some embodiments, the angle is approximately between 0 degrees and 90 degrees. In some embodiments, the cube portion 112 and the cylinder portion 111 may be perpendicular to each other. In some other embodiments, the cube part 112 and the cylinder part 111 may also be parallel to each other. The cuboidal portion 112 and cylindrical portion 111 may be integrally formed, for example, to form a single body. For example, the cuboidal portion 112 may be along the sidewall of the cylindrical portion 111 in some embodiments. In various alternative implementations, the eye imaging device 100 may only include the cylindrical part 111 , or only the cubic part 112 . In some embodiments, the housing of the eye imaging device 100 may have other shapes, and is not limited to a combination of a cylindrical part and a cubic part.

The eye imaging device 100 may be compact to enhance its mobility, maneuverability, and/or portability. For example, in various embodiments, the longest dimension of the eye imaging device 100 may be less than about 250 mm. For example, in some embodiments, the longest dimension of the eye imaging device may be approximately 250 mm, 200 mm, 150 mm, or 100 mm. In some embodiments, the eye imaging device 100 may weigh less than about 1 kg. For example, in various embodiments, the eye imaging device 100 may weigh between about 0.5 kg and 1 kg, between about 0.3 kg and 1 kg, or between about 0.2 kg and 1 kg. Relative to other systems, the small size and light weight of the eye imaging device 100 can advantageously increase the portability of the device 100, thus allowing the user to easily move the device 100 to different places And it is easy to operate the device 100 during use.

In various implementations, the eye imaging device 100 may include an anterior segment imaging module 101 and a main module 102 . In various embodiments, the front-end imaging module 101 is configured to be repeatedly removed from and attached to the main module 102 . The anterior imaging module 101 may be placed in the anterior portion 116 of the cylindrical portion 111 of the housing. The main module 102 can be placed in the rear part 118 of the cylindrical part 111 and possibly also in the cuboidal part 112 of the housing. The handheld eye imaging device 100 can be used to image the posterior segment of the eye through the anterior segment imaging module 101 . In various implementations, the front-end imaging module 101 can be detachable and can be replaced by other imaging and illumination optical components. When the imaging and illumination optics can be removed and replaced, the potential applications of the eye imaging device 100 can be significantly expanded. For example, the eye imaging device 100 may be used to image the posterior segment of the eye at different magnifications and under different lighting conditions, including illumination from broadband or narrowband spectrum light sources. The patient's iris may or may not need to be dilated with special medications before the imaging procedure begins. The captured color image of the posterior segment of the eye can be a planar (2D) or stereoscopic (3D) image. The anterior segment imaging module 101 may be designed to image the anterior segment of the eye. The anterior segment imaging module 101 can also be replaced by an ultrasound probe, which will be described in detail below.

The main module 102 may include a computing and communication unit. In some implementations, the computing and communication unit may include a handheld computing device 104, eg, a modified mobile computing device. For example, the handheld computing device 104 shown in FIG. 1 is a modified smartphone; in other embodiments, the handheld computing device 104 may be any other suitable modified mobile computing device. For example, in some configurations the improved mobile computing device 104 may comprise a retrofit device. The improved mobile computing device 104 may include any low power central processing unit (CPU), graphics processing unit (GPU), operating system, touch screen display, microphone, speaker, and miniature digital camera, among other modules for wireless connectivity Such as WiFi, Bluetooth, and/or 3G or 4G or any combination of the above. The improved mobile computing device 104 is capable of providing voice and/or data communications. The improved mobile computing device 104 can also be configured to connect to a wireless data communication network through a wireless connection for web browsing. The improved mobile computing device 104 may have enhanced and expanded high-speed data communication capabilities and higher computing capabilities compared to conventional mobile phones. The modified mobile computing device 104 (eg, a modified smartphone) may be based on a smartphone with an Android or iOS mobile operating system, among other operating systems. The improved mobile computing device 104 may have built-in high-speed data transfer capabilities and high-speed computing capabilities. Adapting a standard mobile smartphone to an improved smartphone can be more cost-effective than designing a computing and communication unit from scratch. In addition, the touch screen display 105 of the mobile computing device 104 can be used as a display to review images and also as a user input interface to control the image capture process. Captured images can be transmitted to other computing devices or Internet-based devices, such as storage units, via wired or wireless communication systems. In various embodiments, the imaging device may be battery powered, thus improving user handling and operation.

The handheld eye imaging device 100 can be designed to be operated by a user with little training. The cylindrical portion 111 can act as a handle allowing the user to easily hold the device 100 with one hand. Users can precisely adjust the position and/or angle of the device with one hand, freeing the other hand for other tasks, such as opening a patient's eyelid with their fingers. The cube portion 112 may include a display screen and/or a user input interface such as a touch screen display 105, allowing the user to manipulate various functions of the imaging device and control the photographing process.

The eye imaging device 100 can be used as a device for disease screening or medical diagnosis in various ophthalmic applications. The device 100 may be used in remote or rural areas where access to eye care facilities is inconvenient. The device 100 can also be used as a portable medical imaging device to meet other medical needs, such as otolaryngology or dermatology applications. In addition, the device 100 may have applications in other fields besides medical applications; for example, in security screening applications, images of the anterior segment or posterior segment of the eye may be used for personal identification purposes. The eye imaging device 100 can also be used to image the eyes of animals. In these applications, the optical design of the device 100 may be substantially the same as that applied to a human eye. In some other embodiments, the optical design of the device 100 can be modified to image the eyes of the animal. For example, the eye imaging device 100 can be used to image and photograph the eyes of animals, such as livestock, pets, and experimental test animals, including horses, cats, dogs, rabbits, rats, guinea pigs, mice, and the like.

FIG. 2(A) and FIG. 2(B) schematically show a handheld eye imaging device 200 . Reference numbers used in FIG. 2 denote components similar to those shown in FIG. 1 , and reference numbers increase in increments of 100, unless otherwise stated. As shown in FIG. 2(A) and FIG. 2(B), the handheld eye imaging device 200 may include a detachable anterior segment imaging module 201 , a main module 202 and a locking ring 203 . The cube part 212 can be installed on the top of the cylinder part 211 at a certain inclination angle, so that the user can operate the device 200 more conveniently. This cube portion 212 may include a touch screen display 205 . However, the orientation of the cuboidal portion 212 shown in FIG. 2 may be different from the cuboidal portion 112 in the embodiment shown and described in FIGS. 2 and 1 . The longer sides of the cuboidal portion 212 in FIG. 2 run from left to right, while the shorter sides of the cuboidal portion 112 in FIG. 1 run from left to right. The orientation of the cube portion 212 in FIG. 2 allows the user to see the image in a more natural manner. However, the long side of the rectangular portion 212 may block the user's view, so that the user cannot directly see the object being photographed.

The imaging device further includes a locking ring 203 configured to mount and/or detach the front imaging module 201 from the main module 202 . For example, the detachable front imaging module 201 can be detached from the main module 202 by rotating or moving the locking ring 203 from a locked position to an unlocked position. The use of the locking ring 203 can not only prevent the module 201 from falling off accidentally; it can also seal the gap between two modules when waterproof sealing is required. The locking ring 203 can be connected to the main module 202 through its mechanical locking structure. The locking structure allows the user to securely connect the front imaging module 201 and the main module 202 , and also detach the front imaging module 201 from the main module 202 . A part of the locking structure can be placed on the front module 201 , and another part can be placed on the main module 202 . Furthermore, a liquid-tight closure comprising two torus-shaped surfaces may be placed within the locking ring 203 and around the cylindrical portion 211 of the housing. The two ring-shaped surfaces can be respectively placed in the front imaging module 201 and the main module 201 , and there can be precisely matched contact surfaces between them. The two donut-shaped surfaces may comprise metal, plastic or rubber material. When the two ring-shaped surfaces are pressed against each other, a liquid-tight seal can be formed to prevent external water or liquid from entering the cylindrical portion 211 of the housing. After the front imaging module 201 is connected to the main module 202, the locking ring 203 can be rotated or moved from an unlocked position to a locked position. Moving the locking ring 203 to the locked position can help prevent accidental movement of the module 201 and can create a fluid-tight seal between the modules 201 and 202 . The locking ring 203 can also be used in the embodiment shown in FIG. 1 .

3(A) and 3(B) schematically show more details of a handheld eye imaging device 300 . In various implementations, the device 300 may include the detachable anterior segment imaging module 301 and the main module 302 . The handheld eye imaging device 300 may be configured to image the anterior and posterior segments of the eye. To form an image of the posterior segment of the eye, the optical window 303 of the detachable anterior segment imaging module 301 can be carefully placed on the cornea of the eye. The optical window 303 can be designed such that the radius of curvature of the anterior surface closely matches the radius of curvature of the cornea. In some embodiments, for example, the outer surface of the optical window can have a radius of curvature between approximately 6 mm and 15 mm. An optical index matching gel can be added between the cornea and the optical window to reduce light scattering and optical aberration. In certain embodiments, the viscosity of the optical index matching gel can be at least about 100 centipoise, at least about 200 centipoise, or at least about 300 centipoise.

As shown in FIG. 3(B), the illuminating light can be projected from the optical window 303 . Light conditioning element 322 may be used to direct light through specific areas on the cornea and lens of the eye and ultimately onto the posterior segment of the eye. An imaging lens 324 positioned behind the optical window 303 can be used to form an image of the posterior portion of the eye including the retinal region as well as the vitreous portion of the posterior portion of the eye. The first set of relay lenses 325 may be used to relay the image of the subsequent segment onto the second imaging surface 328 . The second imaging surface 328 can be placed in the front imaging lens 301 or the main module 302 . A second set of relay lenses 329 may be added for relaying the image of the second imaging plane 328 to the image sensor 320 placed within the main module 302 . The image sensor 320 may be configured to stream live video images and/or capture high resolution still images through various pre-programmed functions. The image sensor 320 may be any suitable image sensor, such as CCD or CMOS sensor. Other types of image sensors can also be used.

The handheld eye imaging device 300 may include at least one focusing lens 321 located in front of the image sensor 320 . The focusing lens or lens group 321 may be configured to adjust the focal length and magnification of the eye imaging device 300 . In various implementations, one or more focusing lenses 321 may be moved or adjusted. For example, one or more focusing lenses 321 may be longitudinally translated relative to one or more other focusing lenses in the lens group 321 along the optical axis of the optical imaging system. Moving the relative positions of the lenses in the focusing lens group 321 can change the effective focal length of the focusing lens group 321, so that the magnification can be changed and the optical zoom of the captured image can be achieved. Actuators such as voice coils, stepper motors or other types of actuators or combinations thereof may be used to longitudinally translate one or more or all of the focusing lenses, thereby changing the effective focal length (S) and/or providing The image is enlarged. During eye imaging, the focusing lens or lens group 321 can be controlled manually or automatically. In the fully automatic mode, the eye imaging device 300 can automatically find the features in the image and try to adjust the focusing lens or the actuators of the lens group 321 to achieve the best focus. In the manual mode, the user can select a focus area on the real-time screen by using the touch screen 305 . The eye imaging device 300 may adjust the focusing lens or lens group 321 to achieve the best focus in a particular area and then provide a visual or audible indication when the selected area is in focus. The brightness or exposure of the image can also be controlled in manual or automatic mode. In the automatic exposure mode, the user can allow the eye imaging device to automatically adjust the brightness of the image according to the preset imaging standard. In addition, the user can fine-tune the exposure by estimating the appropriate exposure for a selected area of the image, which is often the area for fine focus adjustments. The overall brightness of the image can be adjusted or set by the user according to their preferences. The brightness of the image can be controlled by the sensitivity of the image sensor or the brightness of the light source. In some embodiments, when image quality or image noise is a key measure, the sensitivity of the image sensor can be set at a fixed value. The brightness of the light source can be adjusted according to the darkness of the retinal pigment layer so as to achieve the desired brightness. Due to concerns about eye phototoxicity, in order to prevent the illumination brightness from exceeding the specified range, a maximum illumination brightness value can be set.

During the imaging process, the operator may spend a considerable amount of time adjusting the brightness, focus, and field of view of the image while viewing the live image on the screen. The operator can then take a few pictures in a short time. In some embodiments, in order to reduce the exposure of the patient's eyes, the sensitivity of the image sensor can be configured to increase appropriately during the adjustment process, for example, it can be higher than the sensitivity required when capturing images during the imaging process out 2x or 4x. Increased sensitivity may result in 2x or 4x reduction in illumination, although such increased sensor sensitivity may result in higher noise levels in live images and lower image quality. When the operator captures still images during imaging, the sensitivity of the sensor can be configured to temporarily decrease to a desired value to provide acceptable image quality. At the same time, the amount of illumination light can be configured to temporarily increase by the same ratio, which can result in a still image with higher image quality and lower noise with the same exposure and brightness. During the adjustment, the light sensitivity of the sensor may be increased by any level between 2 times, 3 times, 5 times, 8 times and higher than the desired sensitivity level during imaging. In some alternative implementations, the brightness of the light source may be fixed or user-selectable when there is a specific desired exposure value. The sensitivity of the image sensor can be automatically adjusted accordingly.

In various implementations, as shown in FIG. 3(C), the main module 302 of the handheld eye imaging device 300 may include a computing and communication unit 331 and an image processing unit 332 . With continuous reference to FIGS. 3A to 3C , images from the image sensor 320 may be processed by the image processing unit 332 and/or transmitted out of the eye imaging device via a computing and communication device 331 using a wireless or wired communication system. 300. The computing and communication device 331 may include a handheld computing device 304, eg, a modified mobile computing device in various embodiments, with built-in data communication capabilities. In some embodiments, the improved mobile computing device 304 may be housed within the main module 302, while the touch screen display 305 and various control buttons 306 are exposed. The improved mobile computing device 304 may be mounted on the main module 302 . The front imaging module 301 can be installed on the opposite side and the optical window 303 is on the bottom. In some implementations, the improved mobile computing device 304 may be mounted at an inclined angle, thereby allowing a user to more easily operate the improved mobile computing device 304 . In some alternative implementations, the improved mobile computing device 304 may also be installed perpendicular to the optical axis of the front imaging module 301 . The improved mobile computing device 304 also includes a touch screen display 305 . The touch screen display 305 may be configured to display images, including simple planar images and/or stereoscopic (3D) images. In addition, the touch screen display 305 may also have a touch screen control function, so that the operator can interact with the display 305 . The control buttons 306 and 307 can operate through mechanical transmission. The control buttons 306 and 307 can be configured to respond to certain command actions of the user's fingers. The mechanical transmission may include a mechanical structure that translates user actions into commands to which one of the electrical switches on the computing device 304 can respond. For example, the improved mobile computing device 304 may include an electrical switch configured to respond to a pushing action, such as an inwardly applied force relative to the device 304 . When the user slides the button 307, the mechanical transmission converts the user's sliding action into an inward pushing action on the switch. As a result, the electrical switch of the computing device 304 can respond to a sliding action on the button 307 .

The main module 302 may be configured to sequentially and/or simultaneously receive real-time images from the one or more image sensors 320 . The main module 302 can be configured to display real-time images on the touch screen display 305 . The image sensor 320 and image capturing functionality can be controlled on the touch screen display 305 through functions of the modified mobile computing device 304, and/or can be controlled through the Control buttons 306 are controlled, and/or may be controlled through voice control functionality of the mobile computing device 304 . The main module 302 can also be configured to exchange data with other electronic communication devices through wired or wireless communication systems, such as WiFi or 3G standard telecommunication specifications.

As noted above, in various embodiments the eye imaging apparatus 300 may include the improved mobile computing device 304 . For example, in some implementations the handheld computing device 300 may comprise a modified smartphone. The eye imaging device can take advantage of the smartphone's built-in high-speed wireless data communication function and high computing power. However, typical smartphones are primarily configured for audio signal communication with limited input/output communication ports. For example, a smartphone may have only a few output\input communication ports such as a charging input port, a speaker output port, and some control buttons, such as volume adjustment buttons. A conventional smartphone may not be able to control complex devices located outside the phone.

In various embodiments the eye imaging device 300 may include an adaptation module 309 . FIG. 3(C) schematically shows a block diagram of the eye imaging device 300, which includes an adaptation module 309. A conventional smartphone can be modified and reconfigured to control the process of image capture and transmit captured images via said adaptation module 309 . The adaptation module 309 can be added and connected to the improved mobile computing device 304 (eg, the improved smart phone), thereby further extending the control capability and flexibility of the improved smart phone. The adaptation module 309 may be configured to adapt the modified mobile computing device 304, thereby controlling the operation of the light source 323 and the image capture function of the image sensor 320, which may be placed on the The exterior of the improved mobile computing device 304 described above. The adaptation module 309 can also be configured to adapt the modified mobile computing device 304 to control the actuator of the focusing lens or lens group 321 in front of the image sensor 320, thereby adjusting the imaging device 300 of the eye effective focal length and\or magnification. Data from the image sensor 320 , light source 323 and/or actuators of a lens or lens group 321 may be input into the improved mobile computing device 304 via the adaptation module 309 .

The adaptation module 309 may also include a microcontroller 339 and a signal processing unit 360 . In various implementations, the microcontroller 339 may include a central processing unit, memory, and multiple communication output\input ports. In some embodiments, the central processing unit may range from 16-bit to 64-bit. The microcontroller 339 may also include any suitable type of memory device, such as ROM, EPROM, EEPROM, flash memory, and the like. In various implementations, the microcontroller 339 may include an analog-to-digital converter and/or a digital-to-analog converter. The microcontroller 339 may include input/output ports such as I ² C, SCCB, MIPI and RS-232. In some embodiments, a USB or Ethernet port may also be used. The microcontroller 339 can be connected to the light source 323, the image sensor 320, and the actuators of the focusing lens or lens group 321 through a plurality of communication input/output ports. The microcontroller 339 may include a signal processing unit 360 . The signal processing unit 360 may include instructions to convert signals from the image sensor 320 , light source 323 , and actuators of the focusing lens or lens group 321 into input/output signals that can be used by the improved mobile computing device 304 A data format recognized by one of the communication ports. The signal processing unit 360 may also be configured to convert the signal from the improved mobile computing device 304 into a signal recognizable by the actuators of the image sensor 320, light source 323, and focusing lens or lens group 321. a data format. For example, audio input/output ports of the modified mobile computing device 304 may be used in some implementations. Control signals from the image sensor 320 can be read by a microcontroller through an ^I2C port. The signal processing unit 360 within the microcontroller 339 may include a series of instructions to convert the control signal into a series of data encoded as an audio signal, and the microcontroller 339 may output the audio signal to The audio input port of the mobile computing device 304 . The microcontroller 339 may also include another series of instructions to convert the audio signal from the audio output port of the modified mobile computing device 304 into a signal recognizable by the image sensor 320 . Conversion between different signals can use different instructions with different conversion algorithms.

In some implementations, when the required electric power of the light source 323 is significantly higher than that of a conventional light source of a smartphone, the eye imaging device 300 may further include an independent driving module 335 to drive the light source 323 . In some implementations, the driving module 335 may include an integrated multi-channel current source driving chip. The driver chip can adjust the light output or the brightness of the light source based on the pulse width adjustment configuration. As a result, the stand-alone driver module 335 may be configured to drive a light source having a greater power than conventional light sources within a typical smartphone. In addition, as shown in FIG. 3(C), the driving module 355 can be configured to drive multiple light sources 323 simultaneously. The drive module 335 may be powered by a battery within the improved mobile computing device 304 or by a separate battery with greater capacity and current. The control of the light source 323 and the driving module 335 can be performed by the microcontroller 339 in the adaptation module 309 of the improved mobile computing device 304 .

Conventional smartphones typically have a limited number of image sensors and light sources. To extend the functionality of a smartphone to control and drive multiple image sensors, light sources, and focusing lenses, a multiplexing module 314 can be added to the main module, allowing the improved mobile computing device 304 to operate on multiple image sensors 320 and The light sources 323 are switched through the adaptation module 309 . The multiplexing module 314 can act as a digital switch, so that the improved mobile computing device 304 can exchange data with a larger number of image sensors 320 and light sources 323 . Additionally, control of the multiplexing module 314 may be implemented directly through the improved mobile computing device 304 . It should be understood that the multiplexing module 314 may not be used, for example, if the improved mobile computing device 304 is capable of multiplexing to interact with multiple devices.

Advantageously, the eye imaging device can be more cost-effective by utilizing the built-in wireless high-speed communication capabilities of conventional smartphones. However, a handheld computing device may also be provided without the use of a modified mobile computing device. For example, in various embodiments, the handheld computing device may include any suitable computing device that includes a microprocessor, memory, wireless transmitter, and wireless receiver and that can be picked up or carried by a user. For example, in various implementations, the computing device can support email, web browsing, text messaging, and the like. However, in some embodiments, the handheld computing device includes a modified smartphone, tablet computer, or other type of handheld computing device. The handheld computing device may include a modified conventional cell phone, although it may provide less functionality than a modified smart phone. In some implementations, the handheld computing device may not include a touch screen display.

The battery used in the handheld eye imaging device 300 shown in FIG. 3(A) to FIG. 3(C) can be charged by being connected to a cable through a standard USB port or other charging ports. However, the presence of such electrical ports can be problematic in order to maintain the seal of the eye imaging device. One possible solution is to use a charging device without the connecting cable. The main module 302 may also include a power receiver module 338 placed near one side surface of the main module 302 . When the main module 302 is placed next to the charging mat or charging board, the battery of the imaging device 300 can be connected to the electronic receiving module 338 through the power supply from the charging board without using a connecting cable. Perform power exchange for charging.

As shown in FIG. 3(A), the main module 302 can provide a platform for integrating more functional modules and features into the eye imaging device 300 . When the front imaging module 301 is connected with the main module 302, an electrical connection can also be formed between the two modules 301 and 302 so as to supply power to the electronic equipment in the front imaging module 301, and transmit electrons The signal is sent to the main module 302. In some embodiments, the anterior imaging module 301 may be replaced by an ultrasound probe 341 having a similar profile and size as the anterior imaging module 301 . The ultrasound probe 341 may include an A-scan probe and a B-scan probe for measuring the size and structure of the eye. Both types of probes can be provided with an ultrasonic wand (ultrasonic sensor\ultrasonic transducer) 343 with an outer concave surface similar to that of the optical window 303 so that it can be placed during an eye examination On the cornea or eyelids. A gel similar to that used in optical imaging applications can be used between the probe and tissue. The ultrasonic sensor 343 can generate high-frequency sound waves to pass through the eye, and can also detect the reflection (echo) of the sound waves, thereby forming an image of the structure of the eye. Measurements from the A-scan probe can provide structural information about the eye, and measurements from the B-scan probe can provide a cross-sectional, two-dimensional image of the inner eye. Data from the ultrasound probe 341 may be processed by an electronic circuit 342 located in the main module before being sent to the improved computing device 304 by the adaptation module 309 . The resulting results can be displayed on the touch screen display 305, or can be transferred to other computing or display devices.

It should be understood that, in some embodiments, the front imaging module 301 and the main module 302 may not form two separate units. The anterior segment imaging module 301 and the main module 302 can be integrated, that is, the anterior segment imaging module 301 and the main module 302 of the eye imaging device 300 can be permanently fixed together.

FIG. 3(D) is a flowchart of the handheld eye imaging apparatus 300 including a modified mobile computing device 304, according to various embodiments. The eye imaging device 300 may include circuitry built around the modified mobile computing device 304, such as a modified smartphone. The adaptation module 309 can be connected with the modified mobile computing device 304, so as to expand the communication function of the conventional smart phone. Multiplexing module 314 may also be used to expand the ability of the improved mobile computing device 304 to directly control and drive the plurality of image sensors 320 and/or light sources 323 . The image sensor 320 and light source 323 can interact with the improved mobile computing device 304 through an adaptation module 309 . The standard data bus between the multiplexing module 314 and the improved mobile computing device 304 may also include serial ports or parallel ports, as well as MIFI and DVP, as long as there are digital ports required for transmitting digital images. . The data bus may also include an exchange interface/channel to control the actuators of the focusing lens or lens group 321 . In some embodiments, the driver module 335 can also be used to drive a higher power light source 323 . The improved mobile computing device 304 can control the light source 323 and the driver module 335 through the input and output ports of the adaptation module 309 . The real-time images captured by the image sensor 320 may be transmitted to the improved mobile computing device 304, for example in RAW data format. This live image can be processed and collated to form a standard video stream, which can be displayed on the small touch screen display 305 of the modified mobile computing device 304 . The same video stream can be transmitted outside the device 304 in real-time.

As shown in FIG. 3(E) and FIG. 3(C), the eye imaging device 300 in various embodiments may further include a main control button 350 interfaced with the adaptation module 309 . The main control button 350 may comprise a multifunctional and multidirectional button located on the housing of the device 300 . The main control button 350 may be configured to control the light source 323 , actuators of the focusing lens or lens group 321 and the image sensor 320 . For example, in some embodiments, the main control button 350 can be placed on the cylindrical portion 311 of the housing of the eye imaging device 300, thereby allowing the user to easily operate it with one hand. As shown in FIG. 3(E), in some embodiments, the eye imaging device 300 can be held by the user with four fingers, while the main control button 350 can be freely operated with the index finger (or other fingers). Introducing the main control button 350 enables the imaging device 300 to be operated with one hand. The main control button 350 may comprise an electrical switch to control the light source 323 , the actuator of the focusing lens or lens group 321 , and/or the image sensor 320 . Accordingly, the main control button 350 may allow a user to control focus, light intensity, and/or image capturing process using only one finger. For example, in some embodiments, the light intensity of the light source 323 can be adjusted by pushing the main control button 350 to the left and/or right, and the actuator of the focusing lens or lens group 321 can be adjusted by pushing up and/or right. \ Or push down the multi-function control button 350 to adjust. In other embodiments, the light intensity of the light source 323 can be adjusted by pushing the main control button 350 upward or \ and downward, and the actuator of the focusing lens or lens group 321 can also be adjusted by moving the left or \ And push the multi-function control button 350 to the right to adjust. In some embodiments, the main control button 350 can be used as a trigger for the image sensor 320 by pushing the main control button 350 inwardly. Other variations of using the main control button 350 to control the eye imaging device may also be possible.

It can be seen from FIG. 3(E) that the housing of the imaging device 300 may further include a rubber ring 352 with protruding blocks. The protruding pieces of the rubber ring 352 can suitably match the user's palm, so as to allow the user's palm to hold the body of the imaging device 300 tightly. The rubber ring 352 can simply be replaced. Various types of rubber ring 352 may be provided with different sized nubs to fit the size of the user's hand. The rubber grip ring 352 is rotatable along the cylindrical portion of the imaging system, thus allowing a proper fit in the palm of the user. The rubber grip ring 352 can accommodate both left-handed and right-handed users. The rubber grip ring 352 may also include various shapes other than a complete ring shape, such as a partial ring shape.

FIG. 3(C) schematically shows a block diagram of the eye imaging device 300 , which includes a main control button 350 . In various embodiments, the main control button 350 is configured to control the light source 323 , control the actuators of the focusing lens or lens group 321 , and/or the image sensor 320 through the adaptation module 309 . The micro-controller 339 in the adaptation module 309 can convert the actions of the user's finger on the main control button 350 into instructions or signals recognizable by the modified mobile computing device 304 . The communication between the adaptation module 309 and the improved mobile computing device 304 can be realized through the standard output/input ports of the improved mobile computing device 304, and the improved mobile computing device 304 can also be an improved smart phone. For example, a microphone port of the improved mobile computing device 304 may be used to provide such communication. The adaptation module 309 may transmit instructions including a signal (eg, a five-digit signal) to the improved mobile computing device 304 . To do this, the adaptation module 309 may encode a series of electrical pulses representing a five-digit signal into an audio signal, which is then transmitted to the microphone port of the improved mobile computing device 304 . The modified mobile computing device 304 (eg, a modified smartphone) can receive the audio signal as if the audio signal were a voice call. However, the improved mobile computing device 304 may include an additional signal processing unit that includes an additional set of instructions to convert and recognize the received audio signal, thereby recovering the instructions. From the other direction, commands from the mobile device smartphone can be encoded into audio signals and sent to the speaker port. The adaptation module can receive audio signals and interpret them into instructions that can be used by the adaptation module 309 to control the light source 323, or the actuator of the focusing lens or lens group, or the image sensor 320 . In some embodiments, while the speaker port and microphone port of the modified mobile computing device 304 can be used to communicate with the adaptation module 309, other canonical input/output of the modified mobile computing device 304 can also be used port. The adaptation module 309 may include other signal processing units for converting various instructions into signals recognizable by other input/output ports.

Various embodiments of the handheld eye imaging device 300 also include a method of eye imaging. The method includes illuminating the eye with a light source 323, thereby forming an image of the eye through the optical window and imaging lens. The method may also include receiving an image by using an image sensor 320, controlling a light source 323 and image sensor 320 by using a modified mobile computing device 304, receiving and transmitting an image by using the modified mobile computing device 304, such as a modified smartphone image. The image may be an image of the posterior segment of the eye or an image of the anterior segment of the eye. The method may also include adjusting the focus length and magnification by controlling the actuators of the focus lens or lens group 321 using the improved mobile computing device 304 . Additionally, the method may include displaying an image on the touch screen display 305 of the improved mobile computing device 304 .

The handheld eye imaging device 300 may be used to image the posterior segment of the eye or\and the anterior segment of the eye. After proper focus adjustment is completed, the eye imaging device 300 can image the front segment of the eye through the front segment imaging module 301 . However, the image of the anterior segment of the eye captured by the anterior segment imaging module 301 may present a large-area curvature of field. Furthermore, for posterior and anterior imaging to share the same portion of the optical system, the image quality of the posterior and/or anterior may be compromised. However, in order to achieve high imaging quality and achieve special illumination on the front part of the eye, the eye imaging device 300 may also include an external imaging module configured to photograph the front part of the eye. The handheld eye imaging device 300 may also include a stereoscopic color imaging function of the anterior segment of the eye. When using an appropriate three-dimensional display device, captured images can be viewed in stereo (3D).

FIG. 4 schematically shows an external imaging module 460 located on an external portion of the housing of an eye imaging device 400, according to various embodiments. For example, the eye imaging device 400 described in some embodiments may include an anterior imaging module 401 , an external imaging module 460 , a main module 402 , an anterior optical window 403 , and a handheld computing device 404 . In some embodiments, the external imaging module 460 may be disposed on, say, the outside surface of the housing's cuboidal portion 412 (which may have rounded edges in various embodiments). The external imaging module 460 may include two lighting units 405 , 460 and a miniature camera 407 located between the two lighting units 405 , 406 . The lighting units 405, 406 may comprise light sources and possibly light conditioning optics located in front of the light sources. The light source may include a light emitting element. The light emitting elements may comprise solid state light emitters such as light emitting diodes and/or any other element capable of emitting light. The light emitting element can be compact, highly efficient, and driven by low voltage. In some arrangements, the lighting units 405 , 406 may be placed approximately equal distances from the miniature camera 407 . The illumination units 405, 406 may emit light with a narrow-band spectrum, such as a bandwidth less than about 100 nanometers, and wavelengths within the visible, ultraviolet and/or infrared spectrum. The lighting elements 405, 406 may also emit light in a broadband spectral range, such as white light approximately from 400 nm to 700 nm in the visible spectral range. The miniature camera 407 may include an image sensor and at least one focusing lens located in front of the image sensor. The image sensor may comprise a miniature image sensor having a format no larger than about 1/2.2 inch or about 1/3.2 inch. The focusing lens or lens group may comprise a microlens or lens group having a diameter of less than about 10 mm, less than about 5.0 mm, or less than about 2 mm. The miniature camera 407, which may include the image sensor and the focusing lens or lens group, has a length x width between 10mm x 10mm to 5mm x 5mm, or smaller in some arrangements. In some embodiments, the image sensor may have an active area between about 8mm and 4mm x 6mm and 3mm or between about 7mm and 5mm x 5mm and 4mm. The miniature camera 407 can work in the visible light spectrum or the invisible light spectrum, or work in the visible light spectrum and the invisible light spectrum at the same time. In some other implementation manners, the external imaging module 460 may only include one lighting unit.

The external imaging module 460 may also include two additional lighting units 408 , 409 . The two lighting units 408, 409 can be placed near the miniature camera 407, and the lighting units 408/409 can have different purposes. The two lighting elements 408 and 409 may be used to provide special lighting for imaging of the anterior segment of the eye as described above, which will be discussed below. The lighting element 408 may include a solid-state light emitting element, and the light emitted by it is in a broadband spectral range, such as white light visible to human eyes. The light emitted by the illuminating element 409 may be within a narrow-band spectral range or a wide-band spectral range, within the visible light spectrum or non-visible light spectrum of the human eye. The light emitted from said lighting units 405, 406, 408 and/or 409 may be activated simultaneously, in different combinations or individually.

The miniature camera 407 may include a set of focus lens groups with a focus adjustment function, thereby allowing high-quality imaging at different working distances. The focusing lens group may include at least one focusing lens. The focusing lens or lens group may also have an optical zoom function, allowing the user to change the magnification of the captured image of the object within a fixed distance. Actuators, such as voice coils, stepper motors, or other types of actuators, may be used to longitudinally translate one or more or all of the focusing lenses, thereby changing the effective focal length and/or providing zoom. In various embodiments, the focusing lens group can be configured to be movable or adjustable, for example, the position of the entire focusing lens group can be adjusted longitudinally along the optical axis of the external imaging system to change the Effective focal length whereby the focus of the eye imaging device can be changed for anterior segment imaging. In various embodiments, one or more imaging lens groups may be configured to be movable or adjustable, for example, along the optical axis of the external imaging system relative to one or more other focusing lens groups Move or adjust, so as to change the effective optical focal length of the focusing lens group, which can change the magnification of external imaging and realize the optical zoom of the previous image.

Figure 5 schematically shows a particular lighting configuration for an external imaging module 560 in various embodiments. The lighting units 505, 506, 508, 509 may be the same as or similar to the lighting units 405, 406, 408, 409 shown in FIG. 4, respectively. The miniature camera 507 may be the same as or similar to the miniature camera shown in FIG. 4 . The miniature camera 507 may include an image sensor 520 and a set of focusing lenses 522 . The focusing lens group 522 may include at least one focusing lens. The lighting elements 505 and 506 may include light sources and light conditioning optics, and may be configured to emit a divergent light beam. The divergence angle of the illumination elements 505 , 506 may be wide enough to cover imaged objects visible through the image sensor 520 throughout the field of view. The image sensor 520 may be substantially centered and may be positioned between the lighting unit 505 and the lighting unit 506 . The optical axes of the lighting units 505 and 506 may converge on the optical axis of the micro camera 507 . In FIG. 5 , the eye 501 can also be positioned at the converging point of the light beams emitted by the lighting units 505 and 506 . The converging point of the light beams emitted from the illumination units 505 and 506 may be positioned at a distance between about 40 mm and 200 mm from the image sensor 507 . The imaging of the eyes can be done by taking pictures with the miniature camera 507 at or near the center of the pictures 502 and 503 . The intensity and brightness of the light emitted by the lighting units 505 and 506 are adjustable, for example, manually or automatically. Two bright spots 510 and 511 of specularly reflected light from the cornea can be seen in the photo 502 , and the two bright spots originate from the lighting units 505 and 506 respectively. With the optical illumination configuration shown in FIG. 5 , when the illumination units 505 and 506 are activated at the same time, uniform illumination can be generated for the eye 501 ; and when only one illumination unit is activated, a high-contrast image can be produced. The contrast of the image can be adjusted by the ratio of the light intensities from the two lighting units 505 and 506 . Default settings may result in the lighting units 505 and 506 having exactly the same brightness, while the brightness of both units 505 and 506 can be adjusted.

The miniature camera 507 may also include a focus sensor, which can detect the focus state in a specific area, and the specific area refers to an area of the focus area indicated to the user within the real-time imaging window. For example, in photo 502, a small colored square 512 represents the area of the focal zone. A user may select or change the focus area 512 by tapping a desired location within the live image window displayed on the touch screen of the mobile computing device. The color change of the box 512 may indicate whether the object is in focus. In various implementations, the miniature camera 507 can have two focusing modes: manual focusing and automatic focusing. If auto focus is selected, the miniature camera 507 can automatically focus on the target object in the area indicated by the focus area through its own focus sensor and focus lens or lens group. In some embodiments, the actuator of the focusing lens 522 can move one or more focusing lenses 522 longitudinally relative to one or more other focusing lenses 522 along the optical axis of the miniature camera 507, thereby according to A feedback signal from the focus sensor changes the sharpness of the optical image. The focus sensor may include a special chip and/or instructions within the image sensor 520 . The special chip and/or instructions may be based on a measure of image sharpness of the real-time image. In some implementations, the focus sensor may include several special pixels in the image sensor 520, so that the focus of the optical image can be detected in real time. Because the display used by the imaging system to preview the live image typically has a low display resolution, the state of fine focus may be determined by the focus sensor rather than the sharpness of the live image on the display. The resulting focus state may be indicated by a marker in the frame of the real-time image, for example, the color of the focus area 512 or an audible sound. If manual focus is selected, it can be used to capture objects at a predetermined focus distance. In some embodiments, the relative positions of the focusing lens group 522 of the micro-camera 507 can be calibrated to provide a predetermined (fixed) focus distance for the micro-camera. To achieve optimal focus during imaging, the user can move the miniature camera 507 back and forth (by holding the eye imaging device) while using the focus sensor logo 512 as a guide. If the focal length of the focusing lens 522 is also fixed, or a focusing lens 522 with a fixed focal length is used, the optical magnification of the imaging system is also fixed in this case. With the help of the focus sensor, the focus lens 522 with a fixed focal length and/or with a fixed optical focal length can allow the images taken by the user to have a fixed magnification; if it is necessary to perform geometric measurements on the taken images in the future, A fixed magnification will be important.

As shown in FIG. 5, the lighting unit 508 may be used to provide special lighting for the front segment of the eye. The lighting unit 508 can be placed near the image sensor 520 , the distance between them is smaller than the size of the image sensor 520 , or as close as possible to the miniature camera 507 . Special optics may be used in front of the lighting unit 508 to form a focused light beam. Its beam waist (the narrowest part of the beam or the focus of the beam) can be placed at a predetermined distance from the micro-camera 507 between 40mm and 200mm. For example, when the human eye 501 is positioned at the preset distance, the light emitted by the lighting unit 508 can be focused to the vicinity of the same position, but slightly away from the optical axis of the micro camera 507, for example, away from the The optical axis is less than a distance of about 5 millimeters. The photo 503 may show an individual field of view seen from the miniature camera 507 when the eye is photographed. The circle 513 in the center of the photograph 503 may indicate the opening of the iris on the eye. A beam of light from the illumination unit 508 may be focused and projected into the eye from the edge of the opening of the iris, as shown by the spot 514 in the photograph 503 . The configuration of Figure 5 can provide a special lighting condition known as backlight lighting. The retroreflective lighting method may allow a user to observe eye diseases, including cataracts in the eye.

The lighting unit 509 can also be used to provide another special lighting for the imaging of the anterior segment of the eye. The lighting unit 509 can be placed near the image sensor, for example, the distance between them is smaller than the size of the image sensor, or as close as possible to the camera 507 . The light from the lighting unit 509 can form a divergent light beam, and the optical axis of the lighting unit can be almost parallel to the optical axis of the micro camera 507 . The divergence of the light beam can ensure that the objects within the field of view of the micro camera 507 are well illuminated at the working distance. This lighting setup, placing the light source 509 in close proximity to the miniature camera 507, may allow a user to inspect objects in confined spaces or enclosed cavities. When the illumination unit 509 is used to illuminate and image the eyes at close range, a "shadowless" image can be formed, as shown in photo 503 . The bright spot 515 represents the specular reflection of the cornea, which originates from the illumination unit 509 . The lighting conditions created by the lighting unit 509 can also be used as supplemental "background" lighting to photograph cataracts in the eye under retroreflective lighting. For example, the focus indicator area 516 in the photograph 503 may be used to precisely focus on a cataract seen within the lens. In some embodiments, the lighting unit 509 may include a light source, for example, a light-emitting element whose wavelength is in the visible light spectrum (about 450nm to 700nm) or the invisible light spectrum (for example, near infrared light, about 680nm to 850nm) range, or a plurality of light-emitting elements whose wavelengths are within the visible and invisible spectrum. In some other implementations, the lighting unit 509 may include two light emitting elements, one of which has a wavelength in the visible light spectrum range, and the other has a wavelength in the near-infrared spectrum range. The two light emitting elements can be activated individually or simultaneously. When the patient is positioned no more than 200mm from the miniature camera 507, an image of the patient's face illuminated by the illumination unit 509 can be used to diagnose a medical condition called amblyopia. Here, light from the illumination unit 509 may enter the patient's eye and create a diffuse reflection of light from the retinal region. When such light returns through the patient's iris, it often appears as a "red eye" in facial images. If the reflected light from both eyes shows that the opening of the iris is not symmetrical, it can mean that there may be a problem with the eye, such as amblyopia. Additional potential applications for this special lighting could include photographing a patient's ear, mouth and nasal cavities. In other embodiments, the eye imaging device may include the external imaging module, which only includes the lighting unit 508 or only the lighting unit 509 .

As shown in FIG. 5 , various implementations of the external imaging module 560 may use only a single miniature camera 507 . According to some embodiments, FIG. 6(A) and FIG. 6(B) schematically show an eye imaging device 600, which includes a first micro-camera 607b with a first image sensor 627b and a second image sensor The second miniature camera 610b of the sensor 620b is used to capture stereoscopic images. Stereoscopic images may have the advantage of showing depth information and better visualization of transparent media such as the cornea. As shown in FIG. 6(A), the lighting units 605a, 606a, 608a, 609a may function in the same manner as the lighting units 405, 406, 408, 409 shown in FIG. 4 . Meanwhile, the miniature camera 607a and the miniature camera 407 shown in FIG. 4 may include substantially the same optical elements and may perform the same tasks. A second micro-camera 610a can be added near the micro-camera 607a so as to operate synchronously with the micro-camera 607a. In other words, the shutters of miniature cameras 607a and 610a can be opened or closed substantially simultaneously. When focusing on the same target, the miniature cameras 607a and 610a can together form a picture similar to the image seen by two eyes of a person.

Figure 6(B) schematically shows the same illumination of the external imaging module shown in Figure 6(A), wherein the illumination unit 605b, the illumination unit 606b, the miniature camera 607b and the miniature camera 610b are respectively the same as the illumination unit 605a, The lighting unit 606a, the micro camera 607a and the micro camera 610a are the same. An object 610b to be photographed, for example an eye, is positioned near the point of convergence of the light beams emitted by the illumination units 605b and 606b, and also at the point of convergence of the optical axes of the two miniature cameras 607b and 610b. The angle of convergence 604b formed by the optical axes of the two miniature cameras 607b and 610b can be fixed or adjustable. In some embodiments, wherein the convergence angle 604b is fixed, the distance between the target object 601b and the imaging device 600 can be determined according to the size of the target object in the images 602B and 603B and the two miniature cameras The distance between 610b and 607b is selected. Depending on the viewing conditions of the stereoscopic display system, the convergence angle 604b may generally be between about 5 degrees and about 13 degrees. The image 611b from the micro-camera 607b and the image 612b from the micro-camera 610b can be combined and superimposed into one display frame 603b. Because the miniature cameras 607b and 610b are all focused on the converging point of the optical axis, if the target object (such as eyes) is not on the converging point, the images 611b and 612b captured by the miniature cameras 610b and 607b will not be will overlap each other as shown in photo 603b. In order to generate a stereoscopic image with correct focus and stereopsis, the user can move the imaging device 600 back and forth so that the two images 611b and 612b overlap each other as shown in photo 602b. In photograph 602b, two bright spots 613b and 614b represent the specular reflection of the light beams from said illumination units 606b and 605b by the patient's cornea 601b. When the convergence angle 604b is fixed, the working distance when the two images captured by the miniature cameras 607b and 606b completely overlap is also predetermined and fixed. Thus, using two cameras 607b and 610b not only produces a stereoscopic image for review, but also provides an accurate way to set a constant working distance from the object being photographed to the miniature cameras 610b and 607b. In addition, if the focal lengths of the focusing lenses at the front ends of the miniature cameras 610b and 607b are the same, images captured at a constant working distance can also have the same optical magnification. Such a fixed magnification is important for many medical applications, since geometrical measurements of the captured images can be performed at a later stage. In addition, the outline of the photographed object can also be obtained from the calculation of the pair of stereo images. Although the focal lengths of the miniature camera 607b and the miniature camera 610b can be pre-fixed on the converging point of the optical axes of the miniature camera 607b and the miniature camera 610b, the miniature cameras 607b, 610b can also be set to an automatic focus mode, and their The focal length is adjustable.

FIG. 6(B) also schematically shows various implementations of the handheld stereoscopic eye imaging device 600 . In some implementations, the micro-camera 610b can be inclined relative to the optical axis of the micro-camera 607b at a converging angle 604b. In some other implementation manners, the miniature camera 610b can be placed parallel to the miniature camera 607b. Then a small optical component 615b, such as an optical wedge, can be placed at the front end of the micro-camera 610b to change the direction of the optical axis of the micro-camera 610b to meet the required convergence angle 604b. If necessary, the angle at which the direction of the optical axis is bent can be adjusted through the optical component 615b.

Because the lighting units 608a and 609a can be constructed in the same way as the lighting units 508 and 509, the miniature camera 607a alone can perform all the tasks of the miniature camera 507 for the lighting conditions discussed above, including, for example Rear reflector lighting and background lighting. The images may be planar or non-stereoscopic. However, when the image from the miniature camera 610a is added, the stereoscopic image pair can be generated to provide depth information to the user.

The exact locations of the lighting unit 608a, lighting unit 609a, and miniature camera 610a may be different from those shown in FIG. 6(A). For example, the miniature camera 610a could be placed to the right of the miniature camera 607a and still function well. The positions and layouts of the lighting unit 608a, the lighting unit 609a, and the miniature camera 610a can also have other configurations. Any suitable configuration of the lighting unit 608a, lighting unit 609a, lighting unit 605a, lighting unit 606a, miniature camera 607a, and miniature camera 610a may be used.

FIG. 7(A) schematically shows some other implementations of the stereoscopic external imaging module 760, which can perform the same or similar functions as the implementation shown in FIG. 6(A). The lighting units 705a, 706a, 708a, and 709a may be the same or similar to the lighting units 605a, 606a, 608a, and 609a, and may function in the same manner. The stereoscopic pair of micro-cameras 710a and 711a can be synchronized and can work the same or similarly as the pair of micro-cameras 607a and 610a to form a stereoscopic image pair. However, the configuration of the stereoscopic micro camera module 760 shown in FIG. 7(A) is different. In FIG. 7(A), the lighting units 708a and 709a can be placed on the same side as the miniature cameras 710a and 711a, but in FIG. 6(A), the lighting units 608a and 609a are shown as are placed on opposite sides of the miniature cameras 607a and 610a. In FIG. 7(A), the miniature cameras 710a and 711a may be placed symmetrically about the optical axis of the eye. In contrast, in FIG. 6(A), the miniature camera 607A can be placed along the optical axis of the eye; the miniature camera 610a can be placed at a certain distance from the optical axis of the eye. The positions of the lighting units 705a, 706a, 708a, and 709a and the micro-cameras 710a and 711a can also have other changes. For example, the lighting units 708a and 709a may be placed below the miniature cameras 710a and 711a instead of above.

As shown in FIG. 7(B), in some embodiments, a special optical element 712b can be placed in front of the miniature cameras 710b and 711b, which are the same as those shown in FIG. 6(A). The miniature cameras 610a and 611a may be the same or similar. The lighting units 705b, 706b, and 708b may be the same or similar to the lighting units 705a, 706a, and 708a. The external imaging module may include the miniature cameras 710b and 711b, which may be placed such that their optical axes are parallel but may be spaced apart from the special optical element 712b by a certain distance. The special optical element 712b can cause the optical axes of the micro-cameras 710b and 711b to fold symmetrically, thereby forming a converging angle 704b. The special optical element 712b may be in the form of a flat spherical lens or a double wedge prism. The optical power of the special optical element 712b may be fixed or adjustable, resulting in a fixed or adjustable convergence angle 704b. Fig. 7(B) also schematically shows some other implementations of the stereoscopic external imaging module 706 with the fixed convergence angle 704b. The convergence angle 704 can be formed by tilting the optical axes of the micro-camera 713b and the micro-camera 714b.

FIG. 8(A) schematically shows further embodiments of the stereoscopic external imaging module 860 . The external imaging module 860 composed of the lighting units 805a, 806a, 808a, 809a and miniature cameras 810a and 811a can be the same as that shown in FIG. The external imaging modules of miniature cameras 710a and 711a function the same or similarly. However, the position of the lighting unit shown in FIG. 8(A) may be different from the position of the lighting unit in FIG. 7(A). In FIG. 8(A), two lighting elements may be used in the lighting unit 808A to increase the illumination of the target. In some other implementations in FIG. 8(B), the stereoscopic imaging module 860, which includes the lighting units 805b, 806b, 809b and the miniature cameras 810b, 811b, can be combined with a two-dimensional imaging module 870, so The two-dimensional imaging module 870 includes the illumination units 808b, 809b and a miniature camera 807b. The lighting unit 809b can be used in the stereoscopic imaging module 860 and the 2D imaging module 870b. The lighting unit 808b can generate a focused light beam for rear reflective lighting applications. Under illumination from the diverging light beam emitted by the illumination unit 809b, the 2D camera 807b can be used for various imaging applications when stereoscopic images are not required. The light emitted by the lighting unit 808b may be visible or invisible to human eyes. The miniature camera 807b can also operate in manual focus or auto focus mode. The stereoscopic imaging module 860 shown in Fig. 8 (A) and Fig. 8 (B), it comprises miniature camera 810a, 811a and 810b, 811b, can be with above-mentioned miniature camera 710b and 711b shown in Fig. 7 (B) , or 713b and 714b are constructed from similar optical designs.

Various embodiments of the eye imaging device including an external imaging module include a method of imaging an anterior segment of the eye. The imaging method of the front segment of the eye may include illuminating the front segment of the eye by a first lighting unit including a first light source and a second lighting unit including a second light source. The method may include receiving an image of the anterior segment of the eye by using an image sensor. The optical axes of the first and second light sources may converge on the anterior segment of the eye. The image sensor may be placed between the first light source and the second light source. The method also includes controlling the first light source, the second light source, and the image sensor by using a handheld mobile computing device. Also, the method may include receiving and transmitting images through use of the mobile computing device. In some embodiments, the method of imaging the anterior segment of the eye may include illuminating the eye by using an illumination unit comprising a light source located near the image sensor. The lighting unit may be configured to form a focused light beam. The method may also include directing the focused light beam with its beam waist at the edge of the iris opening of the eye, thereby providing retroreflective illumination; and using a handheld computing device to control the light source and image sensor and receive and transmit images. In some embodiments, the method of imaging the anterior segment of the eye may include illuminating the eye by using a light source; the light source producing a diverging beam that is located in close proximity to the image sensor; and directing the light source so that its optical axis is nearly The image sensors are parallel to each other to provide background illumination. The method may also include receiving and transmitting images by controlling the light source using the handheld computing device. In some embodiments, the method of imaging the anterior segment of the eye may further include receiving a second image of the anterior segment of the eye by using a second image sensor, and controlling the second image sensor by using the handheld mobile computing device. The first optical axis of the first image sensor and the second optical axis of the second image sensor may form a convergence angle to form a stereoscopic image.

The handheld eye imaging device may only include the anterior segment imaging module; or include both the anterior segment imaging module and the external imaging module, or a part of the external imaging module. In various embodiments, the eye imaging device may only include the external imaging module. The eye imaging device may be capable of imaging the posterior segment of the eye (eg, the retina) as well as the anterior segment of the eye (eg, the cornea). The eye imaging device may be used as a handheld imaging device to perform screening for eye diseases, including, for example, retinal disease and/or corneal disease screening.

According to some embodiments, FIG. 9 schematically shows a consumable package 901 of the handheld eye imaging device 900 . Because in various embodiments, the optical window of the anterior segment imaging module may directly contact the patient's cornea, the optical window and nearby area should be disinfected before and after each imaging session; typically by using rubbing alcohol. disinfect. Before each imaging session, a small amount of optically clear gel can be applied to the cornea and the optical window of the patient's eye. The consumable package 901 for the handheld eye imaging device may include a sufficient amount of optically index-matched gel in a small tube 903, and two antiseptic sheets 902 and 906, eg, alcohol sheets 902,906. The contents of the consumable pack 901 may only be used for only one imaging session; the consumable pack 901 may be sterilized during manufacture and may be kept in a sterile state. Before use, tear or cut one side of the consumables package 901 , thereby allowing one of the alcohol sheets 902 to be ejected from the consumables package 901 together with the small tube 903 . The alcohol wipe 902 may be used to sanitize the optical window and the front portion of the housing of the eye imaging device prior to each imaging session. The small tube 903 may comprise plastic or other materials. During manufacture, the small tube 903 can be bent behind the alcohol swab 902 and stored inside the package. When a part of the package is cut, the small tube 903 can be released like a spring and ejected from the package. As shown in Figure 9, one end of the small tube 903 may include a top end cap 904, while the other end may be sealed (bonded) within a resilient but airtight container (bottle) 905, which is used to store the optical refraction Rate matching gel. Care should be taken to confirm that the small tube 903 and the container 905 are filled with the optical refractive index matching gel, and there are no air bubbles in the gel. After cutting off the top cap 904, the gel can be extruded from one end of the small tube 903 by squeezing the top of the container 905. After the imaging session is over, the other side of the consumable pack can be cut or torn to remove the second alcohol tablet 906 . The two alcohol swabs 902, 906 and the consumable pack 901 can be disposed of after one-time use.

Fig. 10 schematically shows another embodiment of a disposable consumable pack 1001 for an eye imaging device. The container containing the optical index matching gel 1005 may be placed at one end of the consumable pack 1001 rather than in the middle of the consumable pack as shown in FIG. 9 above. During manufacture, a portion of the flexible tube 1003 may be bent and placed between alcohol swabs 1002, 1006, which are located within the consumable pack 1001. When one side of the consumable package 1001 is cut or torn, the released curved tube 1003 can push the first alcohol sheet 1002 out of the consumable package 1001 . When the top cap 1004 is sheared off, the optical index matching gel can be released by squeezing the container 1005 . When the consumables package is cut or torn, the second alcohol sheet 1006 can be pushed out of the consumables package 1001 .

The optical window and surrounding area can not only be sanitized by alcohol before and after each imaging session, but can also be dipped in a solution of bleach-based chemicals for a more thorough sanitization frequently. FIG. 11 shows a single-use consumable pack 1100 for the disinfection procedure that can be conveniently and directly applied to the eye imaging device 1105 . The disposable kit may include a cup 1101 , a sanitizer 1103 and a hygiene tablet 1104 (such as an alcohol tablet), and the disposable kit may be sterilized and packaged in a compact package for on-site use. The cup 1101 may comprise plastic or other lightweight and resilient material, and the size of the cup 1101 may be configured to conform to the contours of the eye imaging device 1105 . The rim of the cup 1102 may comprise a rubber-like material, and when the cup 1101 is placed on the eye imaging device 1105, the rim 1102 of the cup may act as a rubber band. The disinfectant 1103 may be stored in a sealed package, and when the sealed package is cut or torn, the disinfectant 1103 will be released into the cup 1101 . When the cup 1101 is placed under the optical window of the eye imaging device 1105, the optical window may be immersed in a disinfectant. The tightened rim of the cup 1102 can form a seal around the front of the housing of the eye imaging device 1105, preventing accidental spillage of antiseptic liquid. After the sanitization procedure is complete, the alcohol tablet 1104 can be removed from the closed package and used to clean the surface of the device 1105 from chemical residues. In some embodiments, the sealed package of disinfectant 1103 and alcohol swab 1104 may be placed under the bottom of the cup 1101 during the manufacturing process. When a plurality of said consumable kits are stacked in a larger shipping box, it can help save packing space. However, the package of sanitizer 1103 and alcohol tablet 1104 could also be placed inside the cup and/or against the bottom thereof.

FIG. 12 schematically shows a networked eye imaging system 1200 comprising a handheld eye imaging device 1201 similar to the device 100 shown in FIG. 1 . The handheld eye imaging device 1201 can be used in an eye imaging system. In the eye imaging system 1200, images of the patient's eyes and related patient information can be captured and/or received by the hand-held eye imaging device 1201, and can be input to the image computing module 1202 and stored in the image storage Module 1203. Images and/or other patient information may be shared and/or reviewed via the review module 1204 at the same or different locations. In various implementations, the eye imaging system 1200 may include the handheld eye imaging device 1201 , an image calculation module 1202 , an image storage module 1203 , and a separate image review module 1204 . The hand-held eye imaging device 1201, image calculation module 1202, image storage module 1203, and review module 1204 may have their own power supply/battery, although when the eye imaging device and different imaging modules are connected to each other, the eye The batteries of the imaging device 1201, the image calculation module 1202, the image storage module 1203, and the review module 1204 may be automatically charged. For example, when the eye imaging device 1201 is placed inside the suitcase 1205 and/or is connected to the imaging module 1202, such as via a USB cable, the battery of the eye imaging device 1201 can be The relatively large battery within the imaging module 1202 is automatically charged. When the battery is fully charged, the charging process can be stopped.

Because the device 1201 is relatively compact and portable for the user, the user can carry the eye imaging device 1201 by using a small carrying case 1205 with a handle. For example, in some embodiments, a suitcase may measure less than approximately 600mm x 400mm x 300mm and may weigh less than 15kg. In some embodiments, for example, the suitcase (with or without the handheld device) may be between (600mm to 300mm) x (400mm to 200mm) x (300mm to 150mm). Additionally, in some arrangements, the suitcase 1205 may weigh between about 10 kg and 15 kg; or in some embodiments, between about 5 kg and 15 kg. Dimensions of the eye imaging system 1200 and carrying case 1205 outside the above ranges are also possible.

The handheld eye imaging device 1201 and image computing module 1202 may be stored in the carrying case 1205 and carried by the user. The suitcase 1205 may include a power source, which may be connected to an external power source; including a spare battery 1206 and the aforementioned consumable pack. The backup battery 1206 may be placed at the bottom of the box 1205 . When the handheld eye imaging device 1206 and the image computing module 1202 are both stored in the box 1205 or connected to it, the batteries in the handheld eye imaging device 1201 and the image computing module 1202 can pass through the backup battery 1206 to charge. The eye imaging device 1201 can be configured to operate for a long time by charging the backup battery 1206 with a relatively large capacity without external power supply.

The handheld eye imaging device 1201 may temporarily store the captured images in a memory in the eye imaging device 1201 . The captured images can also be immediately transmitted to the image computing module 1202, such as through a wired or wireless communication system. Wireless transmission may include any suitable wireless protocol, such as WiFi, Bluetooth, and the like. Image transmission from the eye imaging device 1201 to the image computing module 1202 may be in the form of still images and/or live video images with or without real-time image compression processing. After the live video has been transmitted, the real-time image captured by the eye imaging device 1201 can be reviewed in real time on the display of the image calculation module 1292 . The real-time images from the eye imaging device 1201 can also be viewed on one or more larger external display screens, such as display screens 1207 and 1208 , which can receive signals from the image computing module 1202 . The image from the eye device 1201 can also be further processed by the image computing module 1202 to improve the quality of the image. Subsequently, images and other relevant information of the patient may be displayed and/or recorded on the image computing module 1202 . Thus, a user can capture an image using the smaller handheld eye imaging device 1201 on a larger display from the image computing module 1202, or on one or more large displays associated with the image review module 1204 View real-time images on devices, such as displays 1207, 1208. Larger displays 1207, 1208 associated with the review module 1204 may also allow images to be reviewed by more people in a more convenient location. The data transmission between the eye imaging device 1201 and the image computing module 1202 can be bidirectional. For example, data transmission may also allow related patient information to be transmitted synchronously from the image computing module 1202 to the eye imaging device 1201 . According to the needs of the user, the image records in the image calculation module 1202 may include still images and \video clips. Video and still images can have the same or different form\resolution. Images recorded in the image computing module 1202 may be stored to a database, which may be temporary in some embodiments.

The image storage module 1203 may include relatively permanent storage of images and associated patient information. The image storage module 1203 may be placed in a safe place to ensure data security. The data exchange/synchronization between the image calculation module 1202 and the image storage module 1203 can be implemented through a wired or wireless communication system. The storage device in the image storage module 1203 can have super large capacity and information redundancy so as to protect data. The image storage module 1203 may have a database for storing data from one or more devices of the image calculation module 1202 . The review module 1204 may include a display device associated with the image storage device 1203; or a detachable computing device that communicates with the image storage module 1203, for example, through a wired or wireless communication system. In some implementations, the review module 1204 may include one or more detachable or detachable display devices with wireless connection functions, such as one or more tablet computers. The user can use one or more devices of the review module 1204 within a certain range from the image storage module 1203 to view patient information and images.

The eye imaging device 1201 can store images, such as still images or \and video streams, and at the same time directly play video\instant images to multiple display devices 1207 or 1208 without the image computing module 1202 . In some implementations, the user can also operate the eye imaging device 1202 without the computing module 1202; and can directly transmit images to the image storage module 1203 for safe storage. In some other implementations, network storage 1209 (such as the Internet) may be used to store images and other patient data. Images from the eye imaging device 1201 and the image computing module 1202 can be directly transmitted through a wired or wireless network connection instead of using a local memory. Such data transmission may also be bidirectional. Data from the Internet storage 1209 can also be downloaded and synchronized to the eye imaging device 1201 or image computing module 1202 . The images and patient information stored in the image storage module 1203 can be synchronized with the database in the Internet storage 1209, so that the images and patient information can be shared among a larger group of patients.

In various implementations, the color images from the database of the eye imaging device 1201, the image calculation module 1202 or the image storage module 1203 can be printed out by the color printer 1210, and the patient's information can also be selected from the report The printer 1211 prints out. The transfer between the one or more printers 1210, 1211, eye imaging device 1210, image computing module 1202 and image storage module 1203 may be via wireless or wired connections. The printers 1210 and 1211 may also include independent printers. An additional color printer 1212 can be placed inside the suitcase 1205 for more convenient printing of color photos. Additional storage space 1213 may also be provided within the carrying case 1205 for additional optics and other accessories, such as the aforementioned consumable kit.

The eye imaging system can have various embodiments with different configurations, settings and arrangements. FIG. 13 schematically shows some other embodiments of the networked eye imaging system 1300 . The handheld eye imaging device 1301 can be placed on a mobile cart 1315 for convenient use in outpatient clinics and operating rooms. The cart 1315 can be constructed with multiple shelves and wheels to store multiple devices and allow for easy maneuvering in tight spaces. A suitcase 1305 containing the eye imaging device 1301 can be placed on one of the shelves. A user may remove the entire case 1305 from the cart 1315 and subsequently use the case 1305 elsewhere, or may use the case 1305 for storage on the cart 1315 . The image computing module 1302 and backup battery 1306 can also be placed in the suitcase 1305 and used in the same manner as above. When the suitcase 1305 is placed on the shelf of the cart 1315, the power cord of the suitcase can be directly connected to the cart's power supply system; the battery of the suitcase 1305 can be automatically charged. In some implementations, the display 1316 may comprise a display device of the review module 1304 . The display 1316 can be used to display dynamic and static images, and can also display patient related information. In some other implementation manners, the display 1316 may also include the display of the image calculation module 1302 . An information input device 1317 may be placed on a shelf of the cart 1315 to allow a user to enter patient information and navigate through the image computing module 1302 . The input device 1317 may be, for example, a mouse, a keyboard, or a touch screen display connected to the image computing module 1302 . The connection or information exchange between the input device 1317 and the display device 1316 can be through a wireless or wired communication system. The image storage module 1303 can be used to permanently store patient information and images. The printing device 1310 can be used to print out color images and/or print out diagnostic reports on site. According to the needs of the user, the device 1310 may include one or more printers. , the power regulator 1318 can be used to provide power for the hand-held eye imaging device 130, the image calculation module 1302, the image storage module 1303 and the review module 1304 placed on the cart 1315 as required by medical regulations, and Uninterruptible power is provided when the cart 1315 is disconnected from mains power. In various implementations, it may not be necessary to use all of the components shown in FIG. 12 .

FIG. 14 is a schematic block diagram of the networked eye imaging system 1400 including a handheld eye imaging device 1480 in various embodiments. In some embodiments, the eye imaging device 1480 includes a handheld computing device 1401, such as a modified smartphone, and an electronic system built around the handheld computing device. The electronic system can be configured to further increase the control capability and flexibility of the handheld computing device 1401 . In various embodiments, the eye imaging device 1480 may include an anterior segment imaging module 1421 for imaging the posterior segment of the eye. The front imaging module 1421 may include an imaging sensor 1402 and a light source 1403 . In some implementations, the imaging sensor 1402 and light source 1403 can communicate with the handheld computing device 1401 through a standardized data bus, which can include MIPI serial interface or DVP parallel interface of the imaging processor 1402 input interface and the communication\drive port of the light source 1403. In various implementations, the eye imaging device 1480 may also include an external imaging module 1422 . In some implementations, the external imaging module 1422 may optionally include two image sensors 1405 , 1407 and two lighting units 1406 , 1408 . In some embodiments, the two image sensors 1405 , 1407 and the two lighting units 1406 , 1408 may interface with the handheld computing device 1401 via, for example, a multiplexing module 1404 . The multiplexing module 1404 can be built around the canonical data bus of the data image sensor\illumination unit, allowing interaction between the handheld computing device 1401 and a single image sensor and light source. The multiplexing module 1404 can act as a digital switch and can expand the number of image sensors and light sources that the mobile computing device 1401 can access. In addition, control of the multiplexing module 1404 may be accomplished through canonical input/output ports already built into the canonical data bus and/or directly controlled by the handheld computing device 1401 . The standard data bus can also include serial ports or parallel ports other than MPI and DVP, as long as the provided digital interface meets the requirements of digital image transmission. In various embodiments, the data bus may also include interfaces/channels for controlling focus motors or other actuators used in the front imaging module 1421 and the external imaging module 1422 . Although only two imaging modules are shown in FIG. 14 (which include the image sensor 1402, image sensor 1405, image sensor 1407, light source 1403, lighting unit 1406 and/or lighting unit 1406), additional imaging modules, image sensors, and\or light sources are possible and can be added to the configuration. The front imaging module 1421 and/or the external imaging module 1422 may include any reasonable number of image sensors or light sources. In some other implementations, the eye imaging device 1480 may only include the anterior imaging module 1421 or only the external imaging module 1422 .

In order to further expand the function and flexibility of the eye imaging device 1480 , the eye imaging device 1480 may also include an adaptation module 1409 . The adaptation module 1409 may interface with the handheld computing device 1401 through a standard interface port of the handheld computing device 1401, which is typically built around a standard USB port. The adaptation module 1409 may include a microcontroller and a signal processing unit. In some implementations, the adaptation module 1409 may be configured to adapt the handheld computing device 1401 to control the image sensors 1402, 1405, 1407 and light sources 1403, 1406, 1408, while the standard interface ports of the handheld computing device 1401 may not be able to control the image sensor and light sources without the adaptation module 1409. Therefore, in some embodiments, the image sensor 1402 and the light source 1403 can be connected with the handheld computing device 1401 through the adaptation module 1409 .

The eye imaging device 1400 may further include a driving module 1410 . When the power of the light source in the eye imaging device 1400 is greater than the power of a conventional light source in the handheld mobile computing device 1401 (for example, the original light source of a smart phone), the driving module 1410 can be used to provide power and drive higher power light sources. In some implementations, the driving module 1410 can be connected with the light source 1403 , the lighting unit 1406 and the lighting unit 1408 . The driving module 1410 can be powered by a battery in the handheld computing device 1401 or by an independent battery 1411 with a larger capacity and a larger driving current. The handheld mobile computing device 1401 can control the light source 1403 , lighting units 1406 , 1408 and the driving module 1410 through the input/output ports of the adaptation module 1409 . The control of the multiplexing module 1404 can also be performed through the driving module 1410 or directly through the input/output ports of the adaptation module 1409 . Because the latency of a USB-type interface can be considerable, control of the light source 1403, lighting unit 1406, and/or lighting unit 1408 can be communicated via the driver module 1410 with a compliant data bus directly from the handheld computing device 1401 interaction between them. For example, power and status can be set through the driver module 1410 , while real-time triggering can be synchronized through the existing digital input/output ports of the lighting device in the specification data bus of the handheld computing device 1401 .

As shown in FIG. 14 , the real-time images captured by the imaging sensors 1402 , 1405 , 1407 can be transmitted to the handheld computing device 1401 , for example in RAW data format. These real-time images can be processed and collated into a canonical video stream, which can be displayed on the small touch screen display of the handheld computing device 1401 . The same video stream, with or without the video compression process, can be transmitted out of the handheld computing device 1401 in real time and can be received by the image computing module 1412 . The live video stream may be displayed on the touch screen display of the imaging device 1400 and/or on an external display device of the review module 1413 . The live image can be viewed on any display device, allowing the user to preview while minimizing video lag. Depending on the type of shutter used by the imaging sensors 1402, 1405, 1407, the light from the light source 1403, the lighting unit 1406, and the lighting unit 1408 may be continuous or intermittent in order to synchronize with the opening of the shutter. The video stream can be recorded by the handheld computing device 1401 or the image computing module 1412 . The video stream may also be directly transmitted to the external display device on the review module 1413 without being relayed by the image calculation module 1412 . A backup version of the video stream may also be sent to the image storage module 1414 . The data transmission or exchange between the imaging device 1400 , the image calculation module 1412 , the review module 1413 and the image storage module 1414 or any combination thereof can be performed through a wired or wireless communication system.

When the user triggers the shutter to capture a still image, the imaging sensors 1402, 1405, 1407 can be reset to different sensitivities and resolutions. The light output from the light source 1403, lighting unit 1406, and lighting unit 1408 may also be reset to correspond to the new state of the imaging sensors 1402, 1405, 1407 and synchronized with the shutter. Image data, which may be in RAW format, may be transferred from the image sensors 1402, 1405, 1407 to the handheld computing device 1401; and images may be pre-processed through an image processing pipeline in order to generate high quality still images. deal with. The image processing unit, which may be specific to the type of the photographed object, may perform image processing in the handheld computing device 1401 or the image computing module 1412 . The final composite image can be displayed on the display screen of the image calculation module 1412 or on the external display device of the review module 1413 for review by the user. Images can be relatively permanently stored in the image storage module 1414 .

The image storage module 1014 may include a computer database that may be configured to store a complete copy of information including the identification and address of the eye imaging device 1480, patient personal and diagnostic information, and/or time stamps /exposure time parameter. Initial data entry and updating of patient information can be performed in the handheld computing device 1401 or image computing module 1412 . As shown in FIG. 10 , the information can then be automatically updated and synchronized among the handheld computing equipment 1401 , the image computing module 1412 , the review module 1413 , the image storage module 1414 or a combination thereof.

Various embodiments of the networked eye imaging system disclose a method of eye imaging using the networked eye imaging system. In some embodiments, the method may include imaging the eye using a hand-held eye imaging device, transmitting the image to an image computing module, storing the image in an image storage module with a database, and displaying the image on a display or at least a review module with a display larger than the handheld. A method of imaging an eye by using a handheld eye imaging device may include illuminating the eye by using a light source within a housing, receiving an image of the eye by using an image sensor, controlling the light source and image sensor by using a handheld computing device within the housing, controlling the light source and image sensor by using the handheld computing device Receive and send images. In some embodiments, an eye imaging method using a networked eye imaging system may include imaging an anterior segment and a posterior segment of the eye using a hand-held eye imaging device. The method may include illuminating a portion of the rear segment by using a first light source within the housing, and receiving a first image of the rear segment by using a first image sensor. The method may also include illuminating the front portion by using a second light source, and receiving a second image of the front portion by using a second image sensor. The method may include controlling the first and second light sources and the first and second image sensors by using the handheld computing device, and receiving and transmitting the first and second images by using the handheld computing device. The method may also include transmitting the first and second images to an image computing module, storing the first and second images to an image storage module with a database, and displaying the first and second images on a display comprising a large display on a review module, such as in some embodiments a display that is larger than the display on the handheld imaging device.

Although the invention has been disclosed in exemplary embodiments, those skilled in the art will recognize and appreciate that many additions, deletions and modifications to the disclosed embodiments and variations thereof can be made without departing from the scope of the invention. .

Claims (183)

1. a kind of eye imaging devices, including：

Light source, it is configured to illuminate eyes；

Imageing sensor, it is arranged to receive the image of eyes；

Calculate and communication unit, it includes the improved mobile computing device being configured to receive and transmit described image；And

Adaptation module, it is configured to be adapted to described improved mobile computing device to control described light source and imageing sensor.

2. eye imaging devices according to claim 1, wherein said improved mobile computing device includes improved handss Hold computing device.

3. eye imaging devices according to claim 2, wherein said improved mobile computing device is improved intelligence Mobile phone.

4. eye imaging devices according to claim 2, wherein said signal processing unit includes instructing, and will come from institute State imageing sensor and light source signal be converted to described handheld computing device one of input output port discernible Data form, and the signal coming from one of Shu Ru output port of described handheld computing device is converted to described Imageing sensor and the discernible data form of light source.

5. eye imaging devices according to claim 1, also include main control button, and wherein said main control button includes Multi-functional and multi-direction button, wherein said main control button includes electric switch, thus controlled described by described adaptation module Light source and imageing sensor.

6. eye imaging devices according to claim 2, also include at least between eyes and imageing sensor Individual lens；Wherein said lens can be actuated device and be moved, and wherein said adaptation module is further configured to be adapted to Described handheld computing device is to control the actuator of described lens.

7. eye imaging devices according to claim 6, wherein signal processing unit include instructing, and described image is sensed The signal that at least one of actuator of device, light source and lens sends is converted to one of defeated in described handheld computing device Enter the discernible data form of output port, and by one of input of described handheld computing device output port send Signal be converted to the discernible data form of at least one of actuator of described image sensor, light source and lens.

8. eye imaging devices according to claim 6, also include main control button, and wherein said main control button includes Multi-functional and multi-direction button, wherein said main control button includes electric switch, thus controlling light source, image by adaptation module Sensor and the actuator of lens.

9. eye imaging devices according to claim 1, also include the drive module being configured to drive light source.

10. eye imaging devices according to claim 1, also include multiplexing module.

11. eye imaging devices according to claim 2, also include at least one and expose the control outside handheld computing device Button processed, it is configured to machine driving and is operated.

12. eye imaging devices according to claim 1, wherein said calculating and communication unit are configured to wired Communication system is receiving and to transmit image.

13. eye imaging devices according to claim 1, wherein said calculating and communication unit are configured to wirelessly Communication system is receiving and to transmit image.

14. eye imaging devices according to claim 1, wherein said eye imaging devices are configured to be supplied by battery Electricity.

15. eye imaging devices according to claim 3, described improved smart mobile phone include at least following wherein it One：Lower powered CPU, graphics processing unit, operating system, touch-screen display, mike, speaker and nothing Line link block.

16. eye imaging devices according to claim 1, wherein image includes video flowing.

17. eye imaging devices according to claim 1, wherein said light source, imageing sensor and adaptation module are set Put inside the housing.

18. eye imaging devices according to claim 1, wherein said light source and imageing sensor are arranged on shell Exterior section.

A kind of 19. eye imaging devices, including：

Leading portion image-forming module, including：

For illuminating the light source of eyes；

Optical imaging system, including：

Positioned at the optical window of case nose, it has the front concave surface for accommodating eyes；And

Primary module, including：

Imageing sensor, it is arranged to receive the image of the eyes from described optical imaging system,

Calculate and communication unit, including improved mobile computing device, it is configured to receive and transmit described image；And

It is configured to be adapted to described improved mobile computing device thus controlling the adaptation module of described light source and imageing sensor.

20. eye imaging devices according to claim 19, wherein said improved mobile computing device is hand-held calculating Equipment.

21. eye imaging devices according to claim 20, wherein said improved mobile computing device is improved intelligence Can mobile phone.

22. eye imaging devices according to claim 19, wherein said adaptation module includes instructing, and described image is passed The signal that at least one of sensor and light source send be converted to described improved mobile computing device one of input output The discernible data form in port, and by one of input of described improved mobile computing device output port send Signal be converted to the discernible data form of at least one of described image sensor and light source.

23. eye imaging devices according to claim 19, also include main control button, wherein said main control button bag Include multi-functional and multi-direction button, wherein said main control button includes electric switch thus controlling light source and figure by adaptation module As sensor.

24. eye imaging devices according to claim 19, are also included between eyes and imageing sensor at least One lens, at least one lens wherein said can be actuated device and move, and wherein said adaptation module is additionally configured to It is adapted to the actuator to control described lens for the described improved mobile computing device.

25. eye imaging devices according to claim 24, wherein said adaptation module includes instructing, and described image is passed The signal that at least one of actuator of sensor, light source and lens sends is converted to described improved mobile computing device wherein One input the discernible data form of output port, and by one of input of described improved mobile computing device The signal that output port sends is converted to the discernible number of at least one of actuator of described image processor, light source and lens According to form.

26. eye imaging devices according to claim 24, also include a main control button, and wherein said main control is pressed Button includes a multi-functional and multi-direction button, and wherein said main control button includes electric switch thus controlling by adaptation module The actuator of light source, imageing sensor and lens.

27. eye imaging devices according to claim 19, also include the drive module for driving light source.

28. eye imaging devices according to claim 19, also include multiplexing module.

29. eye imaging devices according to claim 19, also include exposing outside improved mobile computing device At least one control knob, it is configured to machine driving and is operated.

30. eye imaging devices according to claim 19, wherein said leading portion image-forming module can be by repeatedly from master Load onto in module and take off.

31. eye imaging devices according to claim 30, wherein said eye imaging devices are additionally included in leading portion imaging Locking ring between module and primary module.

32. eye imaging devices according to claim 19, wherein said leading portion image-forming module is configured to by ultrasound wave Probe replaces.

33. eye imaging devices according to claim 19, wherein said improved mobile computing device is installed in outer The top of shell, wherein said leading portion image-forming module is arranged on the opposite side of described shell, and described optical window is in described shell Bottom.

34. eye imaging devices according to claim 19, wherein said improved mobile computing device is arranged on and light The optical axis learning imaging system has the position at certain inclination angle.

35. eye imaging devices according to claim 19, wherein said improved mobile computing device is arranged on and light Learn the position of the optical axis perpendicular of imaging system.

36. eye imaging devices according to claim 19, wherein said improved mobile computing device is arranged on and light Learn the substantially parallel position of the optical axis of imaging system.

37. eye imaging devices according to claim 19, wherein said eye imaging devices are configured to wired Communication system receives and transmission image.

38. eye imaging devices according to claim 19, wherein said eye imaging devices are configured to wirelessly Communication system receives and transmission image.

39. eye imaging devices according to claim 19, wherein said eye imaging devices are configured to be supplied by battery Electricity.

40. eye imaging devices according to claim 19, wherein said primary module also includes power receiver unit, quilt It is configured to receiving power in the case of not having electric wire to connect.

41. eye imaging devices according to claim 19, described improved mobile computing device include at least following its One of：Low-power CPU, graphics processing unit, operating system, touch-screen display, mike, speaker and Wireless link block.

42. eye imaging devices according to claim 19, wherein said image includes video flowing.

43. eye imaging devices according to claim 19, including the shell with column part and parallelepiped body portion.

44. eye imaging devices according to claim 43, also include the rubber ring with protruding block, wherein said rubber Becket is configured to match with the palm of user along the cylindrical part setting of shell, wherein said protruding block.

45. eye imaging devices according to claim 19, also include the second image-forming module, and it includes secondary light source, the Two imageing sensors, wherein said second imageing sensor is configured to receive the second image of eyes, wherein said adaptation mould Block is additionally configured to be adapted to described improved mobile computing device to control described secondary light source and the second imageing sensor.

A kind of 46. eye imaging devices, including：

Shell；

Outside image-forming module, including：

Lighting unit, including being configured to illuminate the light source of eyes；

Imageing sensor, is arranged to receive the image of eyes；

Wherein said outside image-forming module is arranged on the exterior section of shell；And

In the primary module of inside the shell, including：

Calculate and communication unit, including the improved mobile computing device being configured to receive and transmit described image；And

In the adaptation module of inside the shell, it is described to control that wherein said adaptation module is configured to be adapted to described handheld computing device Light source and imageing sensor.

47. eye imaging devices according to claim 46, wherein said improved mobile computing device includes improved Handheld computing device.

48. eye imaging devices according to claim 46, wherein said improved mobile computing device includes improved Smart mobile phone.

49. eye imaging devices according to claim 46, wherein said adaptation module includes instructing, and described image is passed The signal that at least one of sensor and light source send be converted to described improved mobile computing device one of input output The discernible data form in port, and by one of input of described improved mobile computing device output port send Signal be converted to the discernible data form of at least one of described image sensor and light source.

50. eye imaging devices according to claim 46, also include main control button, wherein said main control button bag Include multi-functional and multi-direction button, wherein said main control button includes electric switch thus controlling light source and figure by adaptation module As sensor.

51. eye imaging devices according to claim 46, are also included between eyes and imageing sensor at least One lens, wherein said lens can be actuated device and move, and it is described that wherein said adaptation module is configured to adaptation Improved mobile computing device is to control the actuator of described lens.

52. eye imaging devices according to claim 51, wherein said adaptation module includes signal processing unit, its bag Include instruction, the signal that at least one of actuator of described image sensor, light source and lens is sent is converted to described improvement Mobile computing device one of input the discernible data form of output port, and improved mobile computing is set Standby one of input the signal that sends of output port be converted in the actuator of imageing sensor, light source and lens at least One of discernible data form.

53. eye imaging devices according to claim 51, also include main control button, wherein said main control button bag Include the multi-functional and multi-direction button being placed on shell, wherein said main control button includes electric switch thus passing through adaptation module Control the actuator of light source, imageing sensor and lens.

54. eye imaging devices according to claim 46, also include the drive module positioned inside the shell, and it is configured to Drive light source.

55. eye imaging devices according to claim 46, also include the multiplexing module positioned inside the shell.

56. eye imaging devices according to claim 46, also include at least one and expose setting in improved mobile computing Control knob outside standby, it is configured to mechanical delay and is operated.

57. eye imaging devices according to claim 46, wherein said eye imaging devices are configured to wired Communication system receives and transmission image.

58. eye imaging devices according to claim 46, wherein said eye imaging devices are configured to wirelessly Communication system receives and transmission image.

59. eye imaging devices according to claim 46, wherein said eye imaging devices are configured to be supplied by battery Electricity.

60. eye imaging devices according to claim 46, wherein said improved mobile device include at least following its One of:Low-power CPU, graphics processing unit, operating system, touch-screen display, mike, speaker and Wireless link block.

61. eye imaging devices according to claim 46, wherein said image includes video flowing.

62. eye imaging devices according to claim 46, also include leading portion image-forming module, it include secondary light source and The optical window of front end, this optical window has the front concave surface for accommodating eyes, and wherein said primary module also includes the second figure As sensor, wherein said second imageing sensor is configured to receive the second image of eyes, and wherein said adaptation module is also It is configured to be adapted to described improved mobile computing device to control described secondary light source and the second imageing sensor.

A kind of 63. hand-held eye imaging devices, including：

Eyes leading portion image-forming module, including：

First lighting unit, including the first light source for illuminating eyes；

Second lighting unit, including the secondary light source for illuminating eyes；

Micro-camera, including：

It is configured to receive the imageing sensor of the image of eyes；And

At least one lens between eyes and imageing sensor；

Wherein said imageing sensor is located between the first lighting unit and the second lighting unit, wherein said first lighting unit Primary optic axis and the second optical axis of the second lighting unit be focused on the optical axis of described micro-camera；

Wherein said eyes leading portion image-forming module is configured to the front section imaging to eyes.

64. hand-held eye imaging devices according to claim 63, the position of wherein said imageing sensor and the first photograph There is the first distance between bright unit, and have second distance and the second lighting unit between, wherein said first distance and second Distance is equal.

65. hand-held eye imaging devices according to claim 63, wherein said first light source includes the first light-emitting component, And secondary light source includes the second light-emitting component.

66. hand-held eye imaging devices according to claim 63, wherein said first lighting unit is configured to send First divergent beams, and the second lighting unit is configured to send the second divergent beams.

67. hand-held eye imaging devices according to claim 63, the light that wherein said first and second light sources send It is in the range of narrow band spectrum.

68. hand-held eye imaging devices according to claim 63, the light that wherein said first and second light sources send It is in the range of broader frequency spectrum.

69. hand-held eye imaging devices according to claim 63, the light that wherein said first and second light sources send It is in visible light spectrum.

70. hand-held eye imaging devices according to claim 63, the light that wherein said first and second light sources send It is in non-visible light frequency spectrum.

71. hand-held eye imaging devices according to claim 63, wherein said imageing sensor includes microsensor, Its form is less than 1/2.2 inch or 1/3.2 inch.

72. hand-held eye imaging devices according to claim 63, wherein said imageing sensor detects visible light spectrum Interior light.

73. hand-held eye imaging devices according to claim 63, wherein said imageing sensor detects non-visible optical frequency Light in spectrum.

74. hand-held eye imaging devices according to claim 63, wherein said hand-held eye imaging devices are configured to Battery-powered.

75. hand-held eye imaging devices according to claim 63, wherein said first and second lighting units are configured For independently activating.

76. hand-held eye imaging devices according to claim 63, wherein said eyes leading portion image-forming module also includes Three lighting units, it includes the 3rd light source, wherein said 3rd lighting unit is placed near imageing sensor, and it is therebetween Distance is less than the size of imageing sensor itself, and is configured to produce focus on light beam, and its beam waist is positioned apart from described The optical axis of micro-camera is less than about at 5mm.

The 77. hand-held eye imaging devices according to claim 76, wherein said 3rd light source includes the 3rd light-emitting component.

The 78. hand-held eye imaging devices according to claim 76, wherein said eyes leading portion image-forming module also includes Four lighting units, it includes the 4th light source, and its distance near imageing sensor is less than the size of imageing sensor itself Position, and be configured to produce divergent beams.

The 79. hand-held eye imaging devices according to claim 78, wherein said 4th light source includes the 4th illumination component.

80. hand-held eye imaging devices according to claim 63, wherein said eyes leading portion image-forming module also includes Three lighting units, it includes the 3rd light source, and near imageing sensor, and distance therebetween is less than imageing sensor The size of itself, and be configured to produce divergent beams.

81. hand-held eye imaging devices described in 0 according to Claim 8, wherein said 3rd light source includes the 3rd light-emitting component.

82. hand-held eye imaging devices described in 0 according to Claim 8, the light that wherein said 3rd light source is launched is in In visible light spectrum.

83. hand-held eye imaging devices described in 0 according to Claim 8, at the light that the 3rd wherein said light source is launched In non-visible light frequency spectrum.

84. hand-held eye imaging devices according to claim 63, also include being configured to the hindfoot portion of eyes is entered Row imaging leading portion image-forming module, wherein said leading portion image-forming module include back segment light source, have recessed before eyes for accommodating The optical window in face, it is located at optical window rear and becomes the imaging len of optical alignment with optical window, wherein said hand-held one-tenth Also include the second imageing sensor of the second image for receiving eyes as device.

85. hand-held eye imaging devices according to claim 63, also include primary module, and it includes calculating and communicates list Unit, this calculating and communication unit include improved mobile computing device, are configured to receive and transmit image, and adaptation mould Block, is configured to be adapted to described improved mobile computing device, thus controlling the first light source, secondary light source and imageing sensor At least one of.

A kind of 86. hand-held eye imaging devices, including：

Eyes leading portion image-forming module, including：

First lighting unit, including

For illuminating the first light source of eyes；And

Optical element in front of the first light source, is configured to produce focus on light beam；And

Micro-camera, including

It is configured to receive the imageing sensor of the image of eyes, it is attached that wherein said first lighting unit is located at imageing sensor Closely, distance therebetween is less than the size of imageing sensor itself；And

At least one lens between eyes and imageing sensor；

The beam waist of wherein said focus on light beam is positioned to be less than about at 5mm apart from the optical axis of micro-camera；

Wherein said eyes leading portion image-forming module is configured to the leading portion of eyes is imaged.

87. hand-held eye imaging devices described in 6 according to Claim 8, wherein said imageing sensor includes form and is less than About 1/2.2 inch or about 1/3.2 inch of microsensor.

88. hand-held eye imaging devices described in 6 according to Claim 8, wherein said imageing sensor is in the visible ray of human eye Work in the range of frequency spectrum.

89. hand-held eye imaging devices described in 6 according to Claim 8, wherein said imageing sensor is non-visible in human eye Work in optical spectrum.

90. hand-held eye imaging devices described in 6 according to Claim 8, wherein said hand-held eye imaging devices are configured to Battery-powered.

91. hand-held eye imaging devices described in 6 according to Claim 8, wherein said first light source includes the first light-emitting component.

92. hand-held eye imaging devices described in 6 according to Claim 8, wherein said eyes leading portion image-forming module also includes Two lighting units, it includes secondary light source, and near imageing sensor, and distance therebetween is less than imageing sensor originally The size of body, wherein said second lighting unit be configured to produce divergent beams, the second of wherein said second lighting unit Optical axis is substantially parallel with the optical axis of micro-camera.

The 93. hand-held eye imaging devices according to claim 92, wherein said secondary light source includes the second light-emitting component.

The 94. hand-held eye imaging devices according to claim 92, the light that wherein said secondary light source sends is located at can See in optical spectrum.

The 95. hand-held eye imaging devices according to claim 92, the light that wherein said secondary light source sends is located at non- In visible light spectrum.

96. hand-held eye imaging devices described in 6 according to Claim 8, also include leading portion image-forming module, are configured to eyes Back segment be imaged, wherein said leading portion image-forming module includes back segment light source, has the light of front concave surface for accommodating eyes Learn window, be located at optical window rear and become the imaging len of optical alignment, wherein said hand-held imaging device with optical window Also include the second imageing sensor of the second image for receiving eyes.

97. hand-held eye imaging devices described in 6 according to Claim 8, are additionally included in the primary module of inside the shell, and it includes calculating And communication unit, described calculating and communication unit include improved computing device, and it is configured to receive and transmit image, and Adaptation module, is configured to be adapted to described improved mobile computing device, thus controlling the first light source, secondary light source and image Sensor.

A kind of 98. hand-held eye imaging devices, including：

Eyes leading portion image-forming module, including：

First lighting unit, including：

First light source, it is arranged to produce divergent beams to illuminate eyes；And

Micro-camera, including：

Imageing sensor, it is configured to receive the image of eyes, and wherein said first lighting unit is located at described image and senses Near device, distance therebetween is less than the size of imageing sensor itself；And

At least one lens between eyes and imageing sensor；

The primary optic axis of wherein said first lighting unit is substantially parallel with the optical axis of described micro-camera；

Wherein said eyes leading portion image-forming module is configured to the leading portion of eyes is imaged.

Hand-held eye imaging devices described in 99. claim 98, wherein said imageing sensor includes microsensor, its lattice Formula is less than about 1/2.2 inch or about 1/3.2 inch.

The 100. hand-held eye imaging devices according to claim 98, wherein said imageing sensor detects and is in visible ray Light in frequency spectrum.

The 101. hand-held eye imaging devices according to claim 98, wherein said imageing sensor detection is in non-visible Light in optical spectrum.

The 102. hand-held eye imaging devices according to claim 98, wherein said hand-held eye imaging devices are configured to Battery-powered.

The 103. hand-held eye imaging devices according to claim 98, wherein said first light source includes the first luminous unit Part.

The 104. hand-held eye imaging devices according to claim 98, the light that wherein said first light source is launched is visible In optical spectrum.

The 105. hand-held eye imaging devices according to claim 98, the light that the first wherein said light source is launched is non- In visible light spectrum.

The 106. hand-held eye imaging devices according to claim 98, also include leading portion image-forming module, are configured to eye The back segment of eyeball is imaged, and wherein said leading portion image-forming module includes back segment light source, has front concave surface for accommodating eyes Optical window, it is located at the rear of optical window and becomes the imaging len of optical alignment with optical window, wherein said hand-held one-tenth As device is additionally included in the second imageing sensor of inside the shell, it is configured to receive the second image of eyes.

The 107. hand-held eye imaging devices according to claim 98, also include the primary module of described inside the shell, it includes Calculate and communication unit, described calculating and communication unit include improved mobile computing device, are configured to receive and transmit figure Picture, and adaptation module, it is described to control that wherein said adaptation module is configured to be adapted to described improved mobile computing device At least one of first light source, secondary light source and imageing sensor.

A kind of 108. three-dimensional handheld eye imaging devices, including：

Eyes leading portion image-forming module, including：

First lighting unit, including the first light source for illuminating eyes；

Second lighting unit, including the secondary light source for illuminating eyes；

First micro-camera, including the first imageing sensor, it is configured to receive the first image of eyes；

Second micro-camera, including the second imageing sensor, it is configured to receive the second image of eyes；

Wherein said first imageing sensor and the second imageing sensor are located at described first lighting unit and the second lighting unit Between,

Second optical axis of the primary optic axis of wherein said first micro-camera and described second micro-camera is with a convergent angle meeting It is poly-,

Wherein said eyes leading portion image-forming module is configured to the leading portion of eyes is imaged.

The 109. three-dimensional handheld eye imaging devices according to claim 108, wherein said first imageing sensor and institute State and have the first distance between the first lighting unit, and have second distance and described second lighting unit between, wherein said One distance and described second distance are substantially equal, and wherein said second imageing sensor is located near the first image sensing The position of device is thus provide three-dimensional imaging.

The 110. three-dimensional handheld eye imaging devices according to claim 109, wherein said first imageing sensor and eye The optical axis of eyeball becomes optical alignment, and wherein said second imageing sensor and described optical axis tilt.

The 111. three-dimensional handheld eye imaging devices according to claim 109, wherein said eyes leading portion image-forming module is also Including the optical element in the front positioned at described second imageing sensor, the wherein second optical axis is in described optical element and the second figure As paralleling with primary optic axis between sensor, wherein said optical element be configured to change the direction of described second optical axis from And form a convergent angle with described primary optic axis.

The 112. three-dimensional handheld eye imaging devices according to claim 108, wherein said first imageing sensor and institute The optical axis stating the second imageing sensor with regard to eyes is symmetrically positioned.

The 113. three-dimensional handheld eye imaging devices according to claim 108, wherein said eyes leading portion image-forming module is also Including the optical element in front of described first image sensor and described second imageing sensor, wherein said primary optic axis And second optical axis be parallel to each other and have certain and described optical element and described first and second imageing sensors between Distance, wherein said special optical element be configured to change described primary optic axis and described second optical axis direction thus Form a convergent angle.

The 114. three-dimensional handheld eye imaging devices according to claim 108, wherein said first imageing sensor and Two imageing sensors are symmetrically inclined thus forming a convergent angle.

The 115. three-dimensional handheld eye imaging devices according to claim 108, wherein said first light source includes one One light-emitting component, and described secondary light source includes second light-emitting component.

The 116. three-dimensional handheld eye imaging devices according to claim 108, wherein said convergent angle is fixing.

The 117. three-dimensional handheld eye imaging devices according to claim 108, wherein said convergent angle is adjustable.

The 118. three-dimensional handheld eye imaging devices according to claim 108, wherein said convergent angle 5 degree to 13 degree it Between.

The 119. three-dimensional handheld eye imaging devices according to claim 108, wherein said first and second light source transmittings The light going out is in the range of narrow band spectrum.

The 120. three-dimensional handheld eye imaging devices according to claim 108, wherein said first and second light source transmittings The light going out is in the range of broader frequency spectrum.

The 121. three-dimensional handheld eye imaging devices according to claim 108, wherein said first and second light source transmittings The light going out is in visible light spectrum.

The 122. three-dimensional handheld eye imaging devices according to claim 108, wherein said first and second light source transmittings The light going out is in non-visible light frequency spectrum.

The 123. three-dimensional handheld eye imaging devices according to claim 108, wherein said first imageing sensor includes First microsensor, its form is less than about 1/2.2 inch or 1/3.2 inch, and wherein said second image sensing Device includes second microsensor, and its form is less than about 1/2.2 inch or about 1/3.2 inch.

The 124. three-dimensional handheld eye imaging devices according to claim 108, wherein said first and second image sensings Device detects the light being in visible light spectrum.

The 125. three-dimensional handheld eye imaging devices according to claim 108, wherein said first and second image sensings Device detects the light being in non-visible light frequency spectrum.

The 126. three-dimensional handheld eye imaging devices according to claim 108, wherein said hand-held three-dimensional eye imaging dress Put be configured to battery-powered.

The 127. three-dimensional handheld eye imaging devices according to claim 108, wherein said first and second lighting units It is configured to be independently activated.

The 128. three-dimensional handheld eye imaging devices according to claim 108, wherein said eyes leading portion image-forming module is also Including the 3rd lighting unit, it includes the 3rd light source and optical element, and wherein said 3rd lighting unit is located at imageing sensor Near, distance therebetween is less than the size of described image sensor itself, and wherein said optical element is configured to produce Focus on light beam, its beam waist is positioned to be less than about at 5mm apart from the optical axis of described micro-camera.

The 129. three-dimensional handheld eye imaging devices according to claim 128, wherein said 3rd light source includes the 3rd Optical element.

The 130. three-dimensional handheld eye imaging devices according to claim 128, wherein said eyes leading portion image-forming module is also Including the 4th lighting unit, it includes the 4th light source, and positioned at the vicinity of imageing sensor, and distance therebetween is less than described The size of imageing sensor itself, is configured to produce divergent beams, the 4th optical axis of wherein said 4th lighting unit and institute The optical axis stating micro-camera is substantially parallel.

The 131. three-dimensional handheld eye imaging devices according to claim 130, wherein said 4th light source includes the 4th Optical element.

The 132. three-dimensional handheld eye imaging devices according to claim 108, wherein outside image-forming module also includes one 3rd lighting unit, it includes the 3rd light source, and the 3rd light source is located near imageing sensor, and distance therebetween is little In the size of imageing sensor itself, and it is configured to produce divergent beams, the 3rd light of wherein said 3rd lighting unit Axle is substantially parallel with the optical axis of described micro-camera.

The 133. three-dimensional handheld eye imaging devices according to claim 132, wherein said 3rd light source includes the 3rd Optical element.

The 134. three-dimensional handheld eye imaging devices according to claim 132, the light that wherein said 3rd light source is launched In visible light spectrum.

The 135. three-dimensional handheld eye imaging devices according to claim 132, the light that wherein said 3rd light source is launched In non-visible light frequency spectrum.

The 136. three-dimensional handheld eye imaging devices according to claim 108, also include leading portion image-forming module, are configured to The back segment of eyes is imaged, wherein said leading portion image-forming module include back segment light source, have recessed before eyes for accommodating The optical window in face, it is located at optical window rear and becomes the imaging len of optical alignment with described optical window, wherein said handss Hold imaging device and also include back segment imageing sensor, be arranged to receive the back segment image of eyes.

The 137. three-dimensional handheld eye imaging devices according to claim 108, also include primary module, and it includes calculating and logical News unit, this calculating and communication unit include improved mobile computing device, and described calculating and communication unit are configured to receive With transmission image, and adaptation module, it is configured to be adapted to described handheld computing device to control described first light source, the second light At least one of source, the first imageing sensor and second imageing sensor.

A kind of 138. three-dimensional handheld eye imaging devices, including：

Eyes leading portion image-forming module, including：

First lighting unit, including the first light source for illuminating eyes；

First micro-camera, including the first imageing sensor being configured to the first image receiving eyes；

Second micro-camera, including the second imageing sensor being configured to the second image receiving eyes；

Wherein said first imageing sensor is located at described first lighting unit, and nearby and the first distance is less than 10mm and described Second imageing sensor is located at described first lighting unit nearby and second distance is less than 10mm,

Second optical axis of the primary optic axis of wherein said first micro-camera and described second micro-camera is with a convergent angle phase Assemble,

Wherein said outside image-forming module is configured to the leading portion of eyes is imaged.

The 139. three-dimensional handheld eye imaging devices according to claim 138, wherein said first imageing sensor and eye The optical axis of eyeball becomes optical alignment, wherein said second imageing sensor next-door neighbour's described first image sensor.

The 140. three-dimensional handheld eye imaging devices according to claim 139, wherein said second imageing sensor and institute State optical axis to tilt.

The 141. three-dimensional handheld eye imaging devices according to claim 139, wherein said outside image-forming module also includes Optical element in front of the second imageing sensor, wherein said optical element be configured to change the direction of the second optical axis from And form a convergent angle with primary optic axis.

The 142. three-dimensional handheld eye imaging devices according to claim 138, wherein said first imageing sensor and Two imageing sensors are symmetrically positioned with regard to the optical axis of eyes.

The 143. three-dimensional handheld eye imaging devices according to claim 142, wherein said eyes leading portion image-forming module is also Including the optical element in front of the first imageing sensor and the second imageing sensor, wherein said optical element is configured to Change the direction of described primary optic axis and described second optical axis thus forming a convergent angle.

The 144. three-dimensional handheld eye imaging devices according to claim 138, the wherein first imageing sensor and the second figure As sensor is symmetrically inclined thus forming a convergent angle.

The 145. three-dimensional handheld eye imaging devices according to claim 138, the wherein first lighting unit also includes optics Element, it is configured to produce focus on light beam, and its beam waist is positioned to be less than about at 5mm apart from the optical axis of eyes.

The 146. three-dimensional handheld eye imaging devices according to claim 138, wherein said first lighting unit is configured For producing divergent beams, the primary optic axis of the wherein first lighting unit is substantially parallel with the optical axis of eyes.

The 147. three-dimensional handheld eye imaging devices according to claim 138, wherein said first light source includes first Optical element.

The 148. three-dimensional handheld eye imaging devices according to claim 138, wherein said convergent angle is fixing.

The 149. three-dimensional handheld eye imaging devices according to claim 138, wherein said convergent angle is adjustable.

The 150. three-dimensional handheld eye imaging devices according to claim 138, wherein convergent angle are at about 5 degree to about 13 Between degree.

The 151. three-dimensional handheld eye imaging devices according to claim 138, wherein said first imageing sensor includes First microsensor, its form is less than about 1/2.2 inch or 1/3.2 inch, and wherein said second image sensing Device includes the second microsensor, and its form is less than about 1/2.2 inch or 1/3.2 inch.

The 152. three-dimensional handheld eye imaging devices according to claim 138, wherein said three-dimensional handheld eye imaging dress Put be configured to battery-powered.

The 153. three-dimensional handheld eye imaging devices according to claim 138, also include leading portion image-forming module, are configured to The back segment of eyes is imaged, wherein said leading portion image-forming module include back segment light source, have recessed before eyes for accommodating The optical window in face, it is placed on described optical window rear and becomes the imaging len of optical alignment with described optical window, its Described in three-dimensional handheld imaging device also include back segment imageing sensor, its be arranged to receive eyes back segment image.

The 154. three-dimensional handheld eye imaging devices according to claim 138, are additionally included in the primary module of inside the shell, its bag Include calculating and communication unit, this calculating and communication unit include handheld computing device, it is arranged to receive and transmits image, with And adaptation module, it is configured to be adapted to described handheld computing device thus controlling described first light source, described first image to pass At least one of sensor and described second imageing sensor.

A kind of 155. hand-held eye imaging devices, including：

Leading portion image-forming module, including：

Back segment light source, it is configured to illuminate the back segment of eyes,

A kind of back segment optical imaging system, including：

Optical window, it has the front concave surface for accommodating eyes；

Imaging len, it is located at described optical window rear and becomes optical alignment with described optical window；Back segment image sensing Device, it is arranged to receive the back segment image of the back segment coming from eyes；And

Eyes leading portion image-forming module, including：

First leading portion lighting unit, including the first leading portion light source, for illuminating the leading portion of eyes；And

Micro-camera, including

Leading portion imageing sensor, it is arranged to receive the leading portion image of the leading portion coming from eyes；And

At least one lens between eyes and leading portion imageing sensor.

The 156. hand-held eye imaging devices according to claim 155, wherein said eyes leading portion image-forming module also includes Second leading portion lighting unit, it includes the second leading portion light source of the leading portion for illuminating eyes, wherein said leading portion image sensing Device is arranged between described first leading portion lighting unit and described second leading portion lighting unit, wherein said first leading portion illumination Second optical axis of the primary optic axis of unit and described second leading portion lighting unit is assembled at the optical axis of described micro-camera.

The 157. hand-held eye imaging devices according to claim 155, wherein said eyes leading portion image-forming module also includes Optical element, wherein said first leading portion lighting unit is placed on the vicinity of leading portion imageing sensor, and therebetween away from From less than the described leading portion imageing sensor size of itself, wherein said optical element is configured to produce focus on light beam, its light The optical axis being positioned apart from described micro-camera with a tight waist is less than about at 5mm.

The 158. hand-held eye imaging devices according to claim 155, wherein said first leading portion lighting unit is placed Near leading portion imageing sensor, and distance therebetween is less than the leading portion imageing sensor size of itself, and wherein said the One leading portion lighting unit is configured to produce divergent beams, and the primary optic axis of wherein said first leading portion lighting unit is micro- with described The optical axis of type camera is substantially parallel.

The 159. hand-held eye imaging devices according to claim 155, wherein said hand-held eye imaging devices are configured For battery-powered.

The 160. hand-held eye imaging devices according to claim 155, also include primary module, and it includes calculating and communicates list Unit, this calculating and communication unit include the handheld computing device being configured to receive and transmit image, and adaptation module, its quilt It is configured to be adapted to described handheld computing device to control described back segment light source, described back segment imageing sensor, described first leading portion At least one of light source and described leading portion imageing sensor.

The 161. hand-held eye imaging devices according to claim 160, wherein said hand-held eye imaging devices are configured For wirelessly receiving and transmitting image.

A kind of 162. lens cleaning devices, including：

A kind of accessory, including：

A kind of consumptive material bag, including：

A kind of small tubes；

The gel that light refractive index in small tubes matches；And alcohol film.

A kind of 163. lens cleaning devices, including：

A kind of consumptive material bag, including：

A kind of have the cup tightening up edge, and the size of wherein said cup is matched with the profile of the front end of handheld camera；

A kind of disinfectant in packaging in sealing, wherein said disinfectant is configured to be discharged in cup；And

Alcohol film.

A kind of 164. eye imaging medical systems, including：

A kind of eye imaging devices, including：

Light source, is configured to illuminate eyes；

Imageing sensor, is arranged to receive the image of eyes；

Calculate and communication unit, it includes improved mobile computing device, is configured to receive and transmit described image；And

Adaptation module, it is configured to be adapted to described handheld computing device controlling described light source and imageing sensor, and

Image computing module, it is configured to receive the image coming from described eye imaging devices and fill with described eye imaging Put and carry out data exchange；

Image storage module, it includes data base, is configured to store described image；And

Inspection module, it includes display, is display configured to described image.

The 165. eye imaging medical systems according to claim 164, wherein said image described eye imaging devices, Carry out real-time Transmission between described image computing module, described image memory module and described inspection module.

The 166. eye imaging medical systems according to claim 164, wherein said image is in described hand-held eye imaging By being wirelessly transferred between device, described image computing module, described image memory module and described inspection module.

The 167. eye imaging medical systems according to claim 164, also include a kind of suitcase, and wherein said eyes become As device is placed in described suitcase.

The 168. eye imaging medical systems according to claim 167, wherein said suitcase is less than 600mm x 400mm x 300mm.

The 169. eye imaging medical systems according to claim 167, wherein said suitcase is placed on mobile handcart Shelf on, wherein information input equipment is placed in described go-cart.

The 170. eye imaging medical systems according to claim 167, wherein said suitcase includes multiple regions, is used for Place described eye imaging devices, described image computing module, power supply, one or more of reserve battery and consumptive material bag.

The 171. eye imaging medical systems according to claim 169, wherein said suitcase also include for place beat The region of print machine.

A kind of 172. test kits, including consumptive material bag, this consumptive material bag includes the light refractive index phase of the q.s in small tubes The gel joined and alcohol film, wherein said small tubes are placed on the rear of at least a piece of alcohol film, wherein said small tubes It is configured to eject at least a piece of alcohol film.

A kind of 173. test kits, including consumptive material bag, it includes the cup with the edge tightened up, the size of wherein said cup with The profile of described camera front end matches；A kind of disinfectant in packaging being placed on sealing, wherein said disinfectant is joined It is set to and be discharged into described cup；And alcohol film.

A kind of 174. eye imaging medical systems, including：

A kind of hand-held eye imaging devices, including：

Eyes leading portion image-forming module, including：

First lighting unit, it includes the first light source for illuminating eyes；

Second lighting unit, it includes the secondary light source for illuminating eyes；

Micro-camera, including：

Imageing sensor, it is configured to receive the image of eyes；And

At least one lens, between eyes and imageing sensor；

Wherein, described image sensor is placed between described first lighting unit and described second lighting unit, wherein institute Second optical axis of the primary optic axis and the second lighting unit of stating the first lighting unit is assembled on the optical axis of described micro-camera；

Wherein, described eyes leading portion image-forming module is configured to the leading portion of eyes is imaged；And

Calculate and communication unit, it is configured to receive and transmit image, and

Image computing module, it is configured to receive the image coming from described eye imaging devices and fill with described eye imaging Put and carry out data exchange；

Image storage module, including data base, it is configured to storage image；And

Inspection module, including display, it is display configured to image.

A kind of 175. eye imaging medical systems, including：

A kind of hand-held eye imaging devices, including：

Shell；

Leading portion image-forming module, including：

Light source, is configured to illuminate eyes；

Optical imaging system, including：

Optical window, it has the front concave surface for accommodating eyes；And

Primary module, including：

Imageing sensor, it is arranged to receive the image of the eyes from optical imaging system；And

Calculate and communication unit, it is configured to receive and transmit image, and

Image computing module, its be configured to receive the image coming from described eye imaging devices and with described eye imaging Device carries out data exchange；

Image storage module, including data base, it is configured to storage image；And

Inspection module, including display, it is display configured to image.

A kind of 176. eye imaging medical systems, including：

A kind of hand-held eye imaging devices, including：

Leading portion image-forming module, including：

Back segment light source, it is configured to illuminate the back segment of eyes；

A kind of back segment optical imaging system, it includes the optics of the front concave surface having for accommodating eyes of the front end positioned at shell Window；

Back segment imageing sensor, it is arranged to receive the back segment image of the back segment from eyes；

Positioned at the eyes leading portion image-forming module of the outside of shell, including：

First leading portion lighting unit, it includes the first leading portion lighting source, for illuminating the leading portion of eyes；

Micro-camera, it includes leading portion imageing sensor, and it is arranged to receive the leading portion image of the leading portion from eyes；And

In calculating and the communication unit of inside the shell, it is configured to receive and transmit image, and

Image computing module, its be configured to receive the image coming from described eye imaging devices and with described eye imaging Device carries out data exchange；

Image storage module, it includes data base, is configured to storage image；And

Inspection module, it includes display, is display configured to image.

A kind of 177. methods of eye imaging, including：

Illuminate eyes by using light source thus forming the image of eyes；

Receive image by using imageing sensor；

Light source and imageing sensor are controlled by adaptation module using improved mobile computing device；And

Receive by using improved mobile computing device and transmission image.

The method of 178. eye imagings according to claim 177, is also included by adaptation module using described improved Mobile computing device, to control the actuator of at least one lens.

The method of 179. eye imagings according to claim 177, is also included described image sensor and described light source In at least one signal of sending described improved mobile computing device is converted to by the signal processing unit in adaptation module One of the discernible data form of input/output end port, and will be defeated for one of described improved mobile computing device Enter/signal that sends of output port is converted in imageing sensor and light source at least by the signal processing unit in adaptation module One discernible data form.

A kind of 180. imaging methods of eyes leading portion, including：

Illuminate the leading portion of eyes using the first lighting unit and the second lighting unit, wherein said first lighting unit includes one First light source, described second lighting unit includes a secondary light source,

Receive the image of eyes leading portion by using imageing sensor, wherein said imageing sensor is positioned described first illumination Between unit and the second lighting unit；

Control described first light source, described secondary light source and described image sensor by using improved mobile device；And

Receive by using described improved mobile computing device and transmission image.

The imaging method of the 181. eyes leading portions according to claim 180, also includes illuminating eye using the 3rd lighting unit The leading portion of eyeball, described 3rd lighting unit includes the 3rd light source, and wherein said 3rd lighting unit is located at described image sensor Near, and distance therebetween is less than the size of described image sensor itself, wherein said 3rd lighting unit is configured For producing focus on light beam, its beam waist is less than about at 5mm in the optical axis apart from eyes.

The imaging method of the 182. eyes leading portions according to claim 181, also includes illuminating eye using the 4th lighting unit The leading portion of eyeball, described 4th lighting unit includes the 4th light source, and wherein said 4th lighting unit is located at described image sensor Near, distance therebetween is less than the size of described image sensor itself, and wherein said 4th lighting unit is configured to Produce divergent beams.

A kind of 183. eye imaging methods by using eye imaging medical system, including：

By using hand-held eye imaging devices, the back segment of eyes and leading portion are imaged, including

The first light source by using inside the shell illuminates eyes back segment,

Receive the first image of eyes back segment by using the first imageing sensor,

Illuminate eyes leading portion by using secondary light source,

Receive the second image of eyes leading portion by using the second imageing sensor,

By using improved handheld computing device, control described first and second light sources, and described first and second images Sensor,

By using described improved handheld computing device, receive and transmit described first and second images；

Described first and second images are sent to image computing module；

Described first and second images are stored in the image storage module with data base；And

The inspection module including big display shows described first and second images.