CN106426899B - Auxiliary device and method for micro-hot embossing rapid prototyping polymer microneedles - Google Patents
Auxiliary device and method for micro-hot embossing rapid prototyping polymer microneedles Download PDFInfo
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- CN106426899B CN106426899B CN201610916532.9A CN201610916532A CN106426899B CN 106426899 B CN106426899 B CN 106426899B CN 201610916532 A CN201610916532 A CN 201610916532A CN 106426899 B CN106426899 B CN 106426899B
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- micropin
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
- B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
- B29C59/022—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing characterised by the disposition or the configuration, e.g. dimensions, of the embossments or the shaping tools therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
- B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
- B29C59/022—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing characterised by the disposition or the configuration, e.g. dimensions, of the embossments or the shaping tools therefor
- B29C2059/023—Microembossing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/753—Medical equipment; Accessories therefor
- B29L2031/7544—Injection needles, syringes
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Casting Or Compression Moulding Of Plastics Or The Like (AREA)
Abstract
The invention discloses a kind of auxiliary devices and method for subfebrile temperature in pression rapid shaping polymer micro needle, lower die plate is located at upper pressure plate lower part, lower die plate is connected with upper pressure plate by coupling part, coupling part includes screw bolt and nut, stacked micropin mold is formed by stacking by multiple sheet cuboids with micropin concave structure, stacked micropin mold is located at the center of lower die plate, tight fit is crossed with lower die plate, the movable plate heart is between upper pressure plate and lower die plate, there is the rectangular parallelepiped space of a polymer sheet for being suitble to place a certain size between the movable plate heart and lower die plate.The present invention is suitable for board-to-board hot stamping device, when hot padding, the device is placed on as a whole between marking press or more mould bases, temperature and pressure needed for polymer sheet deformable filler enters micropin die microstructure both is from marking press, at the end of coining, it is simple to directly take out the auxiliary device auxiliary transposition structure, can greatly shorten imprint time.
Description
Technical field
The present invention relates to polymer subfebrile temperature in pression shaping technologies, more particularly to a kind of subfebrile temperature in pression rapid shaping that is used for polymerize
The auxiliary device of object micropin and the forming method for using the device, belong to polymer micro-structural field shaping technique.
Background technique
Subfebrile temperature in pression technology is a kind of high-precision minute manufacturing technology by microreplicated mold molded micro structure, the low-grade fever
Stamping technique has many advantages, such as that at low cost, accuracy of repetition is high, residual stress is small and is widely used in application and preparation in mechanical, doctor
Micro-cell electron capture detector, micropin, micro-fluidic chip, light guide plate of the every field such as treatment, biology etc..Polymer micro needle medicine-feeding technology combines biography
The advantages of system percutaneous dosing mode subcutaneous administrations and Transdermal delivery systems, such as quick controllable drug delivery, can convey big component
Drug etc., and evaded subcutaneous administrations and given patient's bring feeling of pain, the slow disadvantage of transdermal patch medicine-feeding rate is avoided, this
Outside, the medical staff that profession can not be needed when micropin is administered is administered, and allows patient's self-administration, convenient and safe.
The core of polymer micro needle medicine-feeding technology is exactly micropin, and needle body shape is in cone or asymmetric inclined-plane
Shape is highly differed at 200 μm to 1mm, and needle body draw ratio belongs to big L/D ratio micro-structure usually between 3:1 to 5:1.With micro-
When hot pressing stamped method prepares the micropin of such draw ratio, hot padding temperature is generally at least above glass transition temperature of polymer 10
℃.Before demoulding, it is necessary to so that polymer and mold pressure maintaining is cooled down, just when temperature is reduced to 10 DEG C of glass transition temperature or less
It can demould, otherwise polymer sheet can generate warpage, and molding micro-structure can generate the defects of wire drawing is broken.Hot embossing process packet
Heating, pressure heat-preserving coining, pressure maintaining cooling, release knockout course are included, i.e., needs for polymer and mold to be all heated to before coining
More than the glass transition temperature of polymer, the temperature by polymer and mold is needed all to drop to polymer after pressure heat-preserving coining
It can be demoulded below glass transition temperature, the entire moulding process period is long.The existing method for shortening imprinting cycles is main
There are ultrasonic wave auxiliary heating, graphene coating quick changeable temperature method etc., although these modes solve plate to a certain extent
The problem of thermal imprint process excessive cycle, but these modes exist that structure is complicated, higher cost, service life are short etc. to neglect
Depending on the problem of.
In addition, polymer sheet can be produced due to the effect being under pressure perpendicular to its thickness direction in moulding process
Raw biggish orientation, for the micropin mold spill array of micron level size, especially in the concave structure of array edges
Polymer can be made to be not easy to fill due to this orientation anamorphic effect, caused by the result is that molding polymer micro needle product micropin
High homogeneity is poor, has small, the big phenomenon of center micropin height of apparent edge micropin height, micropin system molding in this way
Product do not meet actual requirement.
Common micropin mold materials have silicon mould, polymeric molds, metal die etc., and silicon mould generally passes through etching method
The microneedle configuration for preparing spill high-aspect-ratio, the micropin concave structure surface smoothness prepared is high, but silicon wafer is more crisp,
In hot embossing process, when the pressure of application is larger, silicon wafer can embrittlement；Polymeric molds are logical such as PDMS, SU-8 sealing rubber die
Photoetching technique preparation is crossed, preparation process is complicated, and matter is soft, is not suitable for the hot padding under the conditions of certain temperature, certain pressure
Process.Metal die can high temperature high voltage resistant, be unlikely to deform, the service life is very long, is that ideal mold prepares material, but in metal mold
The micropin concave structure that high-aspect-ratio is processed on tool is not easy very much.
Summary of the invention
The problem of the purpose of the present invention is to solve plate thermal imprint process excessive cycles, and make polymer in structure
Sheet material is in a coining space, prevents polymer sheet is excessive in moulding process from taking to perpendicular to Deformation in thickness
To being not required to marking press itself when and devising a kind of new micropin mould structure, and then proposing a kind of demoulding and cool down and guarantee
The auxiliary device and method of the preferable rapid shaping polymer micro needle of micropin product consistency.
To achieve the above object, the technical solution adopted by the present invention are as follows: one kind is used for subfebrile temperature in pression rapid shaping polymer
The auxiliary device and method of micropin, when hot padding, the auxiliary device be placed on as a whole marking press upper and lower mould bases it
Between, temperature and pressure needed for polymer sheet deformable filler enters micropin die microstructure both is from marking press, coining knot
Shu Shi directly takes out the auxiliary device, cools down again without marking press；Since polymer sheet is in the movable plate heart and lower die plate
Between the confined space in, in coining, which prevents excessive polymer to excessive perpendicular to thickness direction
Flowing；Micropin mold uses stacked micropin mold, and stacked micropin mold is embedded on lower die plate, the stacked micropin mould
Tool only need to process micropin spill micro-structure in the side of single metal piece when processing micropin spill micro-structure, by complexity
Metal high-aspect-ratio body micro Process is converted into simple face processing.
A kind of auxiliary device for subfebrile temperature in pression rapid shaping polymer micro needle, the device include upper pressure plate 1, activity
The plate heart 2, lower die plate 4, stacked micropin mold 3 and coupling part, lower die plate 4 are located at the lower part of upper pressure plate 1, lower mold
Plate 4 is connected with upper pressure plate 1 by coupling part, and coupling part includes bolt 5 and nut 6；Upper pressure plate 1 and lower die plate 4
The bolt hole for being surrounded by installation, bolt 5 passes through the bolt hole of upper pressure plate 1 and lower die plate 4 and connected by nut 6
It connects；Stacked micropin mold 3 is sequentially overlapped by multiple sheet cuboids with micropin concave structure；Stacked micropin mould
Tool 3 is located at the center of lower die plate 4, and is interference fitted with lower die plate 4；The movable plate heart 2 is located at upper pressure plate 1 and lower die plate
Between 4, there is the space for being suitble to place polymer sheet between the movable plate heart 2 and lower die plate 4.The movable plate heart 2 is
One tetragonous boss structure, the center of upper pressure plate 1 are equipped with inverted tetragonous boss square hole, the movable plate heart 2 and upper pressure plate 1 it
Between match.The thickness of stacked micropin mold 3 is identical with the thickness of lower die plate 4, the upper and lower surface of stacked micropin mold 3
Respectively with the upper and lower surface of lower die plate 4 be overlapped, stacked micropin mold 3 by series of identical size sheet cuboid group
At being carved with the concave structure of the micropin needle body shape of several identical sizes on the single side of sheet cuboid.It uses coupling part
In the positioning and compression of upper pressure plate and lower die plate, bolt 5, nut 6 use countersunk head formula structure.
The present invention also provides a kind of forming methods using subfebrile temperature in pression rapid shaping polymer micro needle auxiliary device, should
Forming method the following steps are included:
Step 1: prepare polymer sheet, the shape of polymer sheet is square or circle.
Ready polymer sheet: being placed in the center of lower die plate 4 by step 2, is placed and is lived on polymer sheet
The movable plate heart 2 makes the movable plate heart 2 and polymer sheet centering, then places upper pressure plate 1, makes 1 center of pressure plate inverted four
Rib boss square hole and the movable plate heart 2 cooperate, and finally connect upper pressure plate 1, the bolt 5 of 4 surrounding of lower die plate, nut 6, make pressure
Tight plate 1 and lower die plate 4 compress.
Step 3: the auxiliary device for being used for subfebrile temperature in pression rapid shaping polymer micro needle connected is placed into plate to plate
On the lower mold holder of formula marking press, when temperature reaches imprint temperature, embossing pressure and imprint time are set, starts to imprint, make
The top mold holder of marking press is pressed on the movable plate heart 2, and then the movable plate heart 2 generates pressure to polymer sheet, makes polymer sheet
It is pressurized, while in the case where heated, polymer sheet Deformation Flow is filled into the stacked micropin at 4 center of lower die plate
In the micropin concave structure of mold 3, after pressure maintaining, marking press die sinking is then taken out micro- for subfebrile temperature in pression rapid shaping polymer
The auxiliary device of needle is quickly cooled down entire auxiliary device with water cooling or other types of cooling.
Step 4: when entire auxiliary device temperature reaches calcining temperature or less, can remove bolt 5, the connection of nut 6,
Pressure plate 1, the movable plate heart 2, lower die plate 4 are separated, in the way of hand ejection or other device assisted demouldings, makes to gather
It closes object sheet material and lower die plate 4 separates, obtain the polymer sheet for having microneedle array.So far the pressure of polymer micro needle is completed
Print forming experiment.If continuing to prepare polymer micro needle, step 1 is repeated to step 4.
The polymer sheet is most amorphous polymers or a part of crystalline polymer, and polymer sheet is poly- first
Base methyl acrylate (PMMA) or polystyrene (PS) or polycarbonate (PC) or polyvinyl chloride (PVC) or polyethylene (PE) etc..
The present invention is used for the forming method of subfebrile temperature in pression rapid shaping polymer micro needle auxiliary device, in coining, upper pressure
Tight plate 1, the movable plate heart 2, polymer sheet, the center of lower die plate 4 four are conllinear in coining direction.When hot padding, bolt 5
End cannot expose the lower surface of lower die plate 4, and nut 6 cannot expose the upper surface of pressure plate 1.
The present invention is used for the forming method of subfebrile temperature in pression rapid shaping polymer micro needle auxiliary device, in entire moulding process
In, hot padding temperature does not cool down because of the taking-up of subfebrile temperature in pression rapid shaping polymer micro needle auxiliary device, not because of low-grade fever
Coining rapid shaping polymer micro needle auxiliary device is put into and heats up, i.e., the temperature control dress of marking press itself in knockout course
Set do not need adjust temperature so that the mould bases up and down of marking press is cooled down, put in subfebrile temperature in pression rapid shaping polymer micro needle auxiliary device
Mould bases keeps the imprint temperature of setting up and down when entering marking press or more mould bases.
The beneficial effects of the present invention are: firstly, polymer sheet is put into entire auxiliary device, without being protected in hot padding
Pressure drop temperature ejection phase directly reduces the temperature of mould bases up and down, so that the time of pressure maintaining cooling ejection phase has not only been saved, and
And the time for heating bolster again has been saved, greatly reduce entire imprinting cycles.
In addition, the movable plate heart is between upper pressure plate and lower die plate, when movable plate heart side in the auxiliary device
When contacting with the side in the truncated rectangular pyramids hole at upper pressure plate center, the movable plate heart will generate a height between lower die plate and be
1mm, length and width are all a rectangular parallelepiped space of 20mm, this space is suitble to place one with a thickness of 1mm-1.2mm, side
Polymer square or round sheet material of the long or diameter less than 20mm, there are two the effects in this space: first is that in moulding process
In, the side wall in the space limits polymer sheet and deforms along perpendicular to the excessive orientation of thickness direction, makes molding polymer
Microneedle array consistency is good；Second is that in imprinting cycles final stage, after entire auxiliary device is taken out from marking press, due to
The movable plate heart coining the maximum moving displacement in direction be 1mm, although with a thickness of 1mm-1.2mm polymer sheet due to be pressurized
Thickness becomes smaller, but there will not be excessive warpage in entire auxiliary device temperature-fall period, the two effects in the space are altogether
With the quality that ensure that polymer micro needle product.
Finally, that is, stacked micropin mould structure, the mold is by multiple length the invention proposes a kind of micropin mould structure
There are a series of micropin concave structures in cube sheet metal composition, a side of each cuboid piece, are processing similar micropin in this way
When such high aspect ratio microstructures, processing method is face processing from the higher body process change of difficulty, and difficulty of processing substantially reduces,
Selection carries out face processing in single side, rather than two sides all carry out micropin concave structure processing, is because of two sides
After all carrying out concave structure processing, adjacent two panels sheet metal is not easy to splice that micropin concave structure completely when splicing, in single side
It, will not when the undressed side of adjacent metal piece and this sheet metal process side split after face carries out the processing of micropin concave structure
Generate problem of misalignment.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the auxiliary device of rapid shaping polymer micro needle.
Fig. 2 is the perspective view of the auxiliary device of rapid shaping polymer micro needle.
Fig. 3 is a cuboid sheet metal of stacked micropin mold.
Fig. 4 is entire stacked micropin mold.
Specific embodiment
Several preferred embodiments of the invention are described in detail below in conjunction with attached drawing, but the present invention is not restricted to
Specific equipment as described below and technical process.The present invention covers any substitution done in the spirit and scope of the present invention, repairs
Change, equivalent method and scheme.
In order to make the public have thorough understanding to the present invention, it is described in detail in the following preferred embodiment of the present invention specific
Details, and the present invention can also be understood completely in description without these details for a person skilled in the art.
Case study on implementation structural schematic diagram such as Fig. 1 for subfebrile temperature in pression rapid shaping polymer micro needle auxiliary device of the present invention
It is shown, perspective view as shown in Fig. 2, the device by upper pressure plate 1, the movable plate heart 2, lower die plate 4, stacked micropin mold
3 and coupling part composition, lower die plate 4 be located at upper 1 lower part of pressure plate, lower die plate 4 and upper pressure plate 1 pass through coupling part company
It connects, coupling part includes bolt 5 and nut 6, and stacked micropin mold 3 is by multiple sheet cuboids with micropin concave structure
It is formed by stacking, stacked micropin mold 3 is located at the center of lower die plate 4 and lower die plate 4 crosses tight fit, and the movable plate heart 2 is located at
Between upper pressure plate 1 and lower die plate 4, having a height between the movable plate heart 2 and lower die plate 4 is 1mm, and long and width is respectively
The rectangular parallelepiped space of 20mm can be placed with a thickness of 1mm-1.2mm, and the long and wide polymer sheet for being respectively 10-20mm is (in figure
It is not drawn into), the present invention is suitable for board-to-board hot stamping device.
The present invention is used for subfebrile temperature in pression rapid shaping polymer micro needle auxiliary device forming method, specific processing step
Are as follows:
Step 1: preparing polymer sheet, and shape is square or round, with a thickness of between 1mm-1.2mm, square
Side length or round diameter are less than 20mm.
Ready polymer sheet: being placed in stacked 3 surface of micropin mold at 4 center of lower die plate by step 2,
The movable plate heart 2 is placed on polymer sheet, makes the movable plate heart 2 and polymer sheet centering, is then placed upper pressure plate 1, is made
2 no-float of truncated rectangular pyramids square hole and the movable plate heart at upper 1 center of pressure plate finally connects four pairs of 5 nuts 6 of bolt, makes compression
Plate 1 and lower die plate 4 compress.
Step 3: the auxiliary device for being used for subfebrile temperature in pression rapid shaping polymer micro needle connected is placed into plate to plate
On the lower mold holder of formula marking press, when temperature reaches imprint temperature, embossing pressure and imprint time are set, starts to imprint, make
The top mold holder of marking press is pressed on the movable plate heart 2, and then the movable plate heart 2 generates pressure to polymer sheet, makes polymer sheet
It is pressurized, while in the case where heated, polymer sheet Deformation Flow, the stacked micropin mould being filled into lower die plate 4
In the micropin concave structure of tool 3, after the pressure maintaining regular hour, marking press die sinking then takes out the polymerization of subfebrile temperature in pression rapid shaping
The auxiliary device of object micropin is quickly cooled down entire auxiliary device with water cooling or other types of cooling.
Step 4: when entire auxiliary device temperature reaches calcining temperature or less, the connection of 5 nut 6 of bolt can be removed, is made
Upper pressure plate 1, the movable plate heart 2 and lower die plate 4 separate, and in the way of hand ejection or other device assisted demouldings, make to gather
It closes object sheet material and lower die plate 4 separates, obtain the polymer sheet for having microneedle array.So far the pressure of polymer micro needle is completed
Print forming experiment.If continuing to prepare polymer micro needle, step 1 is repeated to step 4.
It is as described above according to the embodiment of the present invention, the embodiment described details all there is no detailed descriptionthe,
Not limiting the invention is only the specific embodiment.Obviously, as described above, can make many modifications and variations.This theory
The embodiment that bright book is chosen and specifically described is principle and practical application in order to better explain the present invention, thus belonging to making
Technical field technical staff can be used using modification of the invention and on the basis of the present invention well.The present invention is only by right
The limitation of claim and its full scope and equivalent.
Claims (7)
1. a kind of forming method using subfebrile temperature in pression rapid shaping polymer micro needle auxiliary device, realizes the device packet of this method
Include pressure plate (1), the movable plate heart (2), lower die plate (4), stacked micropin mold (3) and coupling part, lower die plate (4)
Positioned at the lower part of upper pressure plate (1), lower die plate (4) is connected with upper pressure plate (1) by coupling part, and coupling part includes spiral shell
Bolt (5) and nut (6)；The bolt hole for being surrounded by installation of upper pressure plate (1) and lower die plate (4), bolt (5) pass through upper
The bolt hole of pressure plate (1) and lower die plate (4) is simultaneously connected by nut (6)；Stacked micropin mold (3) is by multiple with micro-
The sheet cuboid of needle concave structure is sequentially overlapped；Stacked micropin mold (3) is located at the center of lower die plate (4), and
It is interference fitted with lower die plate (4)；The movable plate heart (2) is between upper pressure plate (1) and lower die plate (4), the movable plate heart (2)
There is the space for being suitble to place polymer sheet between lower die plate (4)；Stacked micropin mold (3) is by series of identical
The sheet cuboid of size forms, and the recessed of the micropin needle body shape of several identical sizes is carved on the single side of sheet cuboid
Shape structure；
It is characterized by: the forming method includes the following steps,
Step 1: prepare polymer sheet, the shape of polymer sheet is square or circle；
Ready polymer sheet: being placed in the center of lower die plate (4) by step 2, the placement activity on polymer sheet
The plate heart (2) makes the movable plate heart (2) and polymer sheet centering, then places upper pressure plate (1), pressure plate (1) center is made to fall
Tetragonous boss square hole and the movable plate heart (2) cooperation set, finally connect the bolt of upper pressure plate (1), lower die plate (4) surrounding
(5), nut (6) compress pressure plate (1) and lower die plate (4)；
Step 3: the auxiliary device for being used for subfebrile temperature in pression rapid shaping polymer micro needle connected is placed into plate to board-like pressure
On the lower mold holder of print machine, when temperature reaches imprint temperature, embossing pressure and imprint time are set, starts to imprint, makes to imprint
The top mold holder of machine is pressed on the movable plate heart (2), and then the movable plate heart (2) generates pressure to polymer sheet, makes polymer sheet
It is pressurized, while in the case where heated, polymer sheet Deformation Flow, the lamination for being filled into lower die plate (4) center declines
Needle mould has in the micropin concave structure of (3), and after pressure maintaining, marking press die sinking then takes out and polymerize for subfebrile temperature in pression rapid shaping
The auxiliary device of object micropin is quickly cooled down entire auxiliary device with water cooling or other types of cooling；
Step 4: when entire auxiliary device temperature reaches calcining temperature or less, can remove bolt (5), nut (6) connection,
Pressure plate (1), the movable plate heart (2), lower die plate (4) are separated, the side of hand ejection or other device assisted demouldings is utilized
Formula separates polymer sheet and lower die plate (4), obtains the polymer sheet for having microneedle array；So far polymerization is completed
The imprinting moulding of object micropin is tested；If continuing to prepare polymer micro needle, step 1 is repeated to step 4.
2. a kind of molding side using subfebrile temperature in pression rapid shaping polymer micro needle auxiliary device according to claim 1
Method, it is characterised in that: the polymer sheet polymethyl methacrylate or polystyrene or polycarbonate or polyvinyl chloride or
Polyethylene.
3. a kind of molding side using subfebrile temperature in pression rapid shaping polymer micro needle auxiliary device according to claim 1
Method, it is characterised in that: in coining, upper pressure plate (1), the movable plate heart (2), polymer sheet, in lower die plate (4) four
The heart is conllinear in coining direction.
4. a kind of molding side using subfebrile temperature in pression rapid shaping polymer micro needle auxiliary device according to claim 1
Method, it is characterised in that: when hot padding, the end of bolt (5) cannot expose the lower surface of lower die plate (4), and nut (6) cannot reveal
The upper surface of upper pressure plate (1) out.
5. a kind of molding side using subfebrile temperature in pression rapid shaping polymer micro needle auxiliary device according to claim 1
Method, it is characterised in that: the movable plate heart (2) is a tetragonous boss structure, and the center of upper pressure plate (1) is equipped with inverted four
Rib boss square hole matches between the movable plate heart (2) and upper pressure plate (1).
6. a kind of molding side using subfebrile temperature in pression rapid shaping polymer micro needle auxiliary device according to claim 1
Method, it is characterised in that: the thickness of stacked micropin mold (3) is identical with the thickness of lower die plate (4), stacked micropin mold
(3) upper and lower surface is overlapped with the upper and lower surface of lower die plate (4) respectively.
7. a kind of molding side using subfebrile temperature in pression rapid shaping polymer micro needle auxiliary device according to claim 1
Method, it is characterised in that: coupling part is used for the positioning and compression of upper pressure plate and lower die plate, and bolt (5), nut (6) use
Countersunk head formula structure.
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| CN201610916532.9A CN106426899B (en) | 2016-10-20 | 2016-10-20 | Auxiliary device and method for micro-hot embossing rapid prototyping polymer microneedles |
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| CN201610916532.9A CN106426899B (en) | 2016-10-20 | 2016-10-20 | Auxiliary device and method for micro-hot embossing rapid prototyping polymer microneedles |
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| CN108578355B (en) * | 2018-05-18 | 2021-08-17 | 黄冈师范学院 | A kind of transdermal drug delivery microneedle system with photothermal effect and preparation method and application |
| CN109228267A (en) * | 2018-11-15 | 2019-01-18 | 陕西宏象房车科技发展有限公司 | Thermoplastic plate reshaping device and forming method |
| CN111300712B (en) * | 2018-12-11 | 2024-12-20 | 尹忠 | A preparation mold and preparation method of drug delivery microneedle |
| CN115400341B (en) * | 2022-08-30 | 2024-02-02 | 华中科技大学 | Soluble polymer microneedle and preparation method thereof |
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| US20140262452A1 (en) * | 2013-02-28 | 2014-09-18 | Ronald Steven Cok | Embossed micro-structure with cured transfer material method |
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| US20150217504A1 (en) * | 2014-02-04 | 2015-08-06 | Kabushiki Kaisha Toshiba | Imprint template and method for manufacturing the same |
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| TWI395657B (en) * | 2010-06-30 | 2013-05-11 | Univ Nat Taiwan Science Tech | A clamping device of micro/nano imprint process |
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|---|---|---|---|---|
| CN104797403A (en) * | 2012-11-05 | 2015-07-22 | 欧姆龙株式会社 | Die structure, transfer molding device, and transfer molding method |
| CN104780968A (en) * | 2012-11-13 | 2015-07-15 | 富士胶片株式会社 | Transdermal absorption sheet, and manufacturing method for same |
| US20140262452A1 (en) * | 2013-02-28 | 2014-09-18 | Ronald Steven Cok | Embossed micro-structure with cured transfer material method |
| US20150217504A1 (en) * | 2014-02-04 | 2015-08-06 | Kabushiki Kaisha Toshiba | Imprint template and method for manufacturing the same |
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