CN106361768A - Composition and preparation thereof for adjuvant therapy of hypertension and diabetes - Google Patents

Abstract

The invention provides a composition for auxiliary treatment of diabetes and hypertension, comprising 40-60 parts of potassium chloride, 80-120 parts of lecithin, 240-360 parts of sugar and 2.4-3.6 parts of magnesium chloride. It can also include 24-36 parts of metformin; the present invention also provides a preparation made from the composition, and the preparation is chewing gum, sublingual tablet or hard candy. The composition for auxiliary treatment of hypertension and diabetes provided by the present invention can regulate the metabolism of potassium ions in the body to treat diabetic complications caused by imbalance of potassium metabolism while maintaining the stability of the internal environment of the body; and the raw materials used in the present invention There are few varieties, so the side effects are small, and the active ingredients can complement each other and play a synergistic effect; after making chewing gum, sublingual tablets or hard candy, it is more convenient to take and carry, and can stimulate saliva by chewing or swallowing Secretion helps to fully absorb the active ingredients and fully exert the curative effect of the composition.

Description

Composition and preparation thereof for auxiliary treatment of hypertension and diabetes

technical field

The invention belongs to the field of health food, and in particular relates to a composition for auxiliary treatment of hypertension and diabetes and a preparation thereof.

Background technique

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia caused by defective insulin secretion or impaired biological function, or both. After millions of years of evolution, the human body has formed a complete system for metabolizing sugar, but this system is not perfect. The human body is prone to potassium deficiency after sugar metabolism is out of balance or after a lot of exercise. At this time, this system has disadvantages. Failure to quickly balance the potassium content in the body will also lead to an imbalance in blood pressure regulation at this time, leading to the occurrence of high blood pressure. Diabetes is accompanied by high blood sugar for a long time, leading to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves, which are commonly known as complications. For a long time, people have generally used insulin injections to regulate blood sugar and control diabetes, but this method has no significant effect on the treatment of diabetic complications. The reason is that most of the complications of diabetes are caused by the abnormality of potassium metabolism, and there is no significant correlation with the content of insulin. For example, blood potassium is in a normal state before a meal, and the potassium content in the cells is insufficient at this time; after a meal, insulin metabolizes sugar and potassium at the same time, causing the body to enter a low potassium state, and symptoms such as weakness, indigestion, and arrhythmia appear. Cause hypernatremia, leading to high blood pressure; at the same time, too high blood sodium will cause cell expansion and cell function damage, especially capillaries are more likely to cause blockage, which may lead to diabetic eye disease and kidney disease in severe cases; High levels will lead to increased uric acid, which will lead to hardening of the arteries and increased systemic or local blood pressure, causing numbness and pain at the extremities. At this time, in addition to supplementing potassium, appropriate phosphorus can also be supplemented. Through the joint action of phosphorus and potassium, the symptoms can be relieved; at the same time, an appropriate amount of magnesium can be added to regulate vasoconstriction and relaxation, and maintain the normal function of cell ion channels. , to regulate blood pressure and prevent the loss of intracellular potassium ions. The invention patent with the authorized notification number CN102894249A discloses a nutrient solution for relieving physical fatigue, including potassium chloride, lecithin, sucrose, peanut polypeptide, hydrolyzed whey protein and various ingredients, which can quickly supplement the nutrients needed by the human body , to quickly restore metabolic balance and maintain internal environment stability. Therefore, by timely supplementing potassium and phosphorus elements and ensuring the supply of sugar, it can also play a certain role in the treatment of diabetic complications.

Contents of the invention

In order to solve the above technical problems, the present invention provides a composition and preparation thereof for auxiliary treatment of diabetes and hypertension.

Concrete technical scheme of the present invention is as follows:

One aspect of the present invention provides a composition for auxiliary treatment of diabetes and hypertension, comprising the following ingredients in parts by weight: 40-60 parts of potassium chloride, 80-120 parts of lecithin, 240-360 parts of sugar and magnesium chloride 2.4 to 3.6 parts, the sugar is at least one selected from glucose, fructose, maltose or sucrose.

Further, the composition also includes 24-36 parts by weight of metformin.

The composition provided by the invention can supplement the potassium, phosphorus and sugar required by the human body, and at the same time regulate the metabolism of potassium ions in the body to treat diabetic complications caused by imbalanced potassium metabolism, while maintaining the stability of the internal environment of the body, improving the State of health.

For the convenience of use, the present invention provides a preparation for auxiliary treatment of hypertension and diabetes, including the aforementioned composition, and the preparation is selected from chewing gum, sublingual tablet, hard candy, spray or mixture.

One aspect of the present invention provides a chewing gum for auxiliary treatment of hypertension and diabetes. The chewing gum includes the following ingredients in parts by weight: 15-25 parts of the composition, 20-35 parts of gum base, 5 parts of plasticizer ~10 servings.

Further, the gum base is a mixture of konjac gum, polyvinyl acetate and Eucommia gum, and the ratio of parts by weight of konjac gum, polyvinyl acetate and Eucommia gum is 1-2:2:1.

The joint use of konjac gum, polyvinyl acetate and Eucommia gum can significantly improve the viscosity and elasticity of the gum base, and greatly improve the chewing taste of the chewing gum.

Further, the plasticizer is a mixture of beeswax, candelilla wax and acetyl ricinoleic acid methyl ester, and the weight and number ratio of the beeswax, candelilla wax and acetyl ricinoleic acid methyl ester is 1:1:1～2.

The combined use of beeswax, candelilla wax and methyl acetyl ricinoleate can significantly enhance the plasticity of the chewing gum, further enhance the softness and lubricity of the chewing gum, and improve the texture and mouthfeel of the chewing gum.

Another aspect of the present invention provides a sublingual tablet for auxiliary treatment of hypertension and diabetes, the sublingual tablet includes the following components in parts by weight: 20-30 parts of the composition, 50-70 parts of the filler parts and lubricant 0.6 to 1 part.

Further, the filler is a mixture of isomalt, sorbitol, α-lactose and microcrystalline cellulose, and the ratio of parts by weight of isomalt, sorbitol, α-lactose and microcrystalline cellulose 1:1:2:2～4.

When isomalt, sorbitol, α-lactose and microcrystalline cellulose are used in combination, the tensile strength and formability of sublingual tablets are significantly better than those of diluents with only one component.

Further, the lubricant is a mixture of magnesium stearate, glyceryl behenate and magnesium lauryl sulfate, and the ratio of parts by weight of magnesium stearate, glyceryl behenate and magnesium lauryl sulfate is 1 ~3:1:1.

The combined use of magnesium stearate, glyceryl behenate and magnesium lauryl sulfate can significantly improve the lubricating performance, significantly improve the efficiency of the granulation and tabletting process, and increase the hardness of the tablet.

Another aspect of the present invention also provides a hard candy for auxiliary treatment of hypertension and diabetes, the hard candy includes the following components in parts by weight: 20-30 parts of the composition, 10-15 parts of honey, 10-15 parts of steviol glycoside, 3-5 parts of mint, 3-5 parts of concentrated lemon juice and 0.01 part of compound trace elements, which include chromium picolinate, zinc gluconate, iron citrate, manganese sulfate , copper sulfate and cobalt sulfate.

Honey and steviol glycosides can provide sweetness to hard candies and reduce sugar intake for users; mint and concentrated lemon juice can improve the taste of hard candies and reduce the feeling of sweetness; adding compound trace elements to hard candies, users Various elements can be added to maintain the normal physiological functions of the body.

The present invention also provides the application of the composition for auxiliary treatment of hypertension and diabetes in the preparation of medicines for auxiliary treatment of hypertension and diabetes

The beneficial effects of the present invention are: the composition provided by the present invention for auxiliary treatment of hypertension and diabetes can supplement the potassium, phosphorus and sugar required by the human body, and at the same time, the metabolism of potassium ions in the body can be regulated by adding magnesium ions, so that Treat diabetic complications caused by potassium metabolism imbalance, maintain the stability of the body's internal environment, and regulate blood pressure; at the same time, by treating diabetic complications and regulating blood pressure, it can relieve the accompanying symptoms of heart discomfort and achieve the effect of adjuvant treatment of heart diseases , thereby improving the health status of the patient as a whole; and the kind of raw materials used in the present invention is few, so side effects are small, and can realize that each active ingredient complements each other and synergistically exerts the purpose of curative effect; after making chewing gum or sublingual tablet or hard candy , it is more convenient to take and carry. By chewing or swallowing, it can stimulate saliva secretion, help to fully absorb the active ingredients, and can give full play to the curative effect of the composition; through sublingual administration, the sublingual capillaries can quickly absorb the active ingredients Absorption, and the absorption rate is consistent with the sugar absorption rate and insulin release rate, which can ensure safety and effectiveness; the addition of various auxiliary agents makes the compound Chinese medicine composition more stable in nature, helps to maintain its therapeutic effect, and can Provides a good taste and is more convenient to take.

detailed description

Example 1

A composition for auxiliary treatment of hypertension and diabetes, comprising 40 parts of potassium chloride, 80 parts of lecithin, 120 parts of glucose, 120 parts of maltose and 2.4 parts of magnesium chloride.

Example 2

A composition for auxiliary treatment of hypertension and diabetes, comprising 50 parts of potassium chloride, 100 parts of lecithin, 150 parts of fructose, 150 parts of sucrose and 3 parts of magnesium chloride.

Example 3

A composition for auxiliary treatment of hypertension and diabetes, comprising 60 parts of potassium chloride, 120 parts of lecithin, 140 parts of glucose, 140 parts of fructose, 100 parts of maltose, 3.6 parts of magnesium chloride and 36 parts of metformin.

Example 4

A composition for auxiliary treatment of hypertension and diabetes, comprising 50 parts of potassium chloride, 100 parts of lecithin, 150 parts of glucose, 150 parts of sucrose, 3 parts of magnesium chloride and 30 parts of metformin.

Example 5

A chewing gum for auxiliary treatment of hypertension and diabetes, said chewing gum comprising 15 parts of the composition described in Example 1, 20 parts of gum base and 5 parts of plasticizer, said gum base comprising 5 parts of konjac gum, polyacetic acid 10 parts of vinyl ester and 5 parts of Eucommia gum.

Example 6

A chewing gum for the auxiliary treatment of hypertension and diabetes, said chewing gum comprising 25 parts of the composition described in Example 2, 35 parts of gum base and 10 parts of plasticizer, said gum base comprising 14 parts of konjac gum, polyacetic acid 14 parts of vinyl ester and 7 parts of Eucommia gum, the plasticizer includes 2.5 parts of beeswax, 2.5 parts of candelilla wax and 5 parts of methyl acetyl ricinoleate.

Example 7

A chewing gum for auxiliary treatment of hypertension and diabetes, said chewing gum comprising 25 parts of the composition described in Example 3, 35 parts of gum base and 10 parts of a plasticizer, said plasticizer including 3.33 parts of beeswax, a small amount of 3.33 parts of candelabra wax and 3.33 parts of methyl acetyl ricinoleate.

Example 8

A chewing gum for auxiliary treatment of hypertension and diabetes, said chewing gum comprising 15 parts of the composition described in Example 4, 20 parts of gum base and 5 parts of plasticizer, said gum base comprising 6 parts of konjac gum, polyacetic acid 6 parts of vinyl ester and 3 parts of Eucommia gum, the plasticizer includes 1.25 parts of beeswax, 1.25 parts of candelilla wax and 2.5 parts of methyl acetyl ricinoleate.

Example 9

A sublingual tablet for the auxiliary treatment of hypertension and diabetes, said sublingual tablet comprising 20 parts of the composition described in Example 1, 50 parts of a filler and 0.6 parts of a lubricant, said filler including isomalt 8.33 8.33 parts of sorbitol, 16.66 parts of α-lactose and 16.66 parts of microcrystalline cellulose.

Example 10

A sublingual tablet for the auxiliary treatment of hypertension and diabetes, the sublingual tablet includes 30 parts of the composition described in Example 2, 70 parts of a filler and 1 part of a lubricant, and the filler includes isomalt 8.75 8.75 parts of sorbitol, 17.5 parts of α-lactose and 35 parts of microcrystalline cellulose. The lubricant includes 0.6 parts of magnesium stearate, 0.2 parts of glyceryl behenate and 0.2 parts of magnesium lauryl sulfate.

Example 11

A sublingual tablet for the auxiliary treatment of hypertension and diabetes, said sublingual tablet comprising 30 parts of the composition described in Example 3, 70 parts of filler and 1 part of lubricant, said lubricant comprising magnesium stearate 0.33 parts, 0.33 parts of glyceryl behenate and 0.33 parts of magnesium lauryl sulfate.

Example 12

A sublingual tablet for auxiliary treatment of hypertension and diabetes, said sublingual tablet comprising 20 parts of the composition described in Example 4, 50 parts of a filler and 0.6 parts of a lubricant, said filler including isomalt 6.25 6.25 parts of sorbitol, 12.5 parts of α-lactose and 25 parts of microcrystalline cellulose, the lubricant includes 0.2 parts of magnesium stearate, 0.2 parts of glyceryl behenate and 0.2 parts of magnesium lauryl sulfate.

Example 13

A hard candy for auxiliary treatment of hypertension and diabetes, the hard candy includes 20 parts of the composition, 10 parts of honey, 10 parts of stevioside, 3 parts of mint, 3 parts of concentrated lemon juice and 0.01 parts of compound trace elements The composite trace elements include chromium picolinate, zinc gluconate, iron citrate, manganese sulfate, copper sulfate and cobalt sulfate.

Example 14

A hard candy for auxiliary treatment of hypertension and diabetes, comprising 30 parts of the hard candy composition, 15 parts of honey, 15 parts of stevioside, 5 parts of mint, 5 parts of concentrated lemon juice and 0.01 part of compound trace elements , the composite trace elements include chromium picolinate, zinc gluconate, ferric citrate, manganese sulfate, copper sulfate and cobalt sulfate.

Comparative example 1

A composition for auxiliary treatment of hypertension and diabetes, comprising 100 parts of lecithin, 150 parts of fructose, 150 parts of sucrose and 3 parts of magnesium chloride.

Comparative example 2

A composition for auxiliary treatment of hypertension and diabetes, comprising 50 parts of potassium chloride, 150 parts of glucose, 150 parts of maltose and 3 parts of magnesium chloride.

Comparative example 3

A composition for auxiliary treatment of hypertension and diabetes, comprising 50 parts of potassium chloride, 100 parts of lecithin and 3 parts of magnesium chloride.

Comparative example 4

A composition for auxiliary treatment of hypertension and diabetes, comprising 50 parts of potassium chloride, 100 parts of lecithin, 150 parts of glucose and 150 parts of fructose.

Comparative example 5

A composition for auxiliary treatment of hypertension and diabetes, comprising 100 parts of lecithin, 200 parts of glucose, 3 parts of magnesium chloride and 30 parts of metformin.

Comparative example 6

A composition for auxiliary treatment of hypertension and diabetes, comprising 50 parts of potassium chloride, 300 parts of glucose, 3 parts of magnesium chloride and 30 parts of metformin.

Comparative example 7

A composition for auxiliary treatment of hypertension and diabetes, comprising 50 parts of potassium chloride, 100 parts of lecithin, 3 parts of magnesium chloride and 30 parts of metformin.

Comparative example 8

A composition for auxiliary treatment of hypertension and diabetes, comprising 50 parts of potassium chloride, 100 parts of lecithin, 200 parts of glucose and 30 parts of metformin.

Comparative example 9

A kind of chewing gum for auxiliary treatment of hypertension and diabetes, said chewing gum comprises 25 parts of the composition described in Comparative Example 1, 35 parts of gum base and 10 parts of plasticizer, said gum base is polyvinyl acetate, so Said plasticizer comprises 5 parts of beeswax and 5 parts of methyl acetyl ricinoleate.

Comparative example 10

A chewing gum for auxiliary treatment of hypertension and diabetes, said chewing gum comprising 25 parts of the composition described in Comparative Example 2, 35 parts of gum base and 10 parts of plasticizer, said gum base including 14 parts of Eucommia gum and poly 21 parts of vinyl acetate, and described plasticizer is 2.5 parts of beeswax.

Comparative Example 11

A chewing gum for auxiliary treatment of hypertension and diabetes, said chewing gum comprising 25 parts of the composition described in Comparative Example 4, 35 parts of gum base and 10 parts of plasticizer, said gum base comprising 14 parts of konjac gum and poly 21 parts of vinyl acetate, and the plasticizer includes 5 parts of beeswax and 5 parts of methyl acetyl ricinoleate.

Comparative example 12

A chewing gum for auxiliary treatment of hypertension and diabetes, said chewing gum comprising 25 parts of the composition described in Comparative Example 5, 35 parts of gum base and 10 parts of plasticizer, said gum base comprising 14 parts of Eucommia gum and poly 21 parts of vinyl acetate, and the plasticizer includes 5 parts of candelilla wax and 5 parts of methyl acetyl ricinoleate.

Comparative example 13

A sublingual tablet for auxiliary treatment of hypertension and diabetes, said sublingual tablet comprising 30 parts of the composition described in Comparative Example 1, 70 parts of filler and 1 part of lubricant, said filler including isomalt 35 parts part and 35 parts of sorbitol, and the lubricant includes 0.6 part of magnesium stearate and 0.4 part of magnesium lauryl sulfate.

Comparative example 14

A sublingual tablet for auxiliary treatment of hypertension and diabetes, said sublingual tablet comprising 30 parts of the composition described in Comparative Example 2, 70 parts of filler and 1 part of lubricant, said filler including 35 parts of α-lactose part and 35 parts of microcrystalline cellulose, and the lubricant includes 0.6 part of magnesium stearate and 0.4 part of glyceryl behenate.

Comparative Example 15

A sublingual tablet for auxiliary treatment of high blood pressure and diabetes, said sublingual tablet comprising 30 parts of the composition of Control Example 4, 70 parts of filler and 1 part of lubricant, said filler including isomalt 20 parts, 20 parts of α-lactose and 30 parts of microcrystalline cellulose, the lubricant includes 0.5 part of glyceryl behenate and 0.5 part of magnesium lauryl sulfate.

Comparative Example 16

A sublingual tablet for the auxiliary treatment of hypertension and diabetes, said sublingual tablet comprising 30 parts of the composition of the control group 5, 70 parts of filler and 1 part of lubricant, said filler including sorbitol 30 parts and 40 parts of microcrystalline cellulose, the lubricant is magnesium stearate.

Experimental example 1

Chewing gum chewing taste evaluation test

The chewing gums provided in Examples 5-8 were used as experimental groups 1-4, and the chewing gums provided in Comparative Examples 9-12 were used as control groups 1-4. Ten evaluators were invited to taste each group of chewing gums, and scored the softness, hardness and elasticity of fresh goose juice in each group. The full score for each item was 50 points, and the total score was 100 points. At the same time, the chewing time of each group of chewing gums was recorded. Each assessor scored independently without communicating with each other, and there was an hour interval between two tastings, gargling with water and supplementing oral moisture with water.

Table 1 Sensory evaluation results of chewing gum in each group

As can be seen from Table 1, the mouthfeel scores of the experimental group 1-4 were significantly higher than those of the control group 1-4, and the chewing time was also significantly higher than that of the control group 1-4, indicating that the chewing gums of the experimental groups had a better mouthfeel when chewed. Well, at the same time, chewing for a longer time can also make the active ingredients in the chewing gum absorb and utilize more efficiently, and play a better role. It can be seen that the combination of konjac gum + polyvinyl acetate + Eucommia gum as the gum base, and the combination of beeswax + candelilla wax + acetyl ricinoleic acid methyl ester as the plasticizer can give chewing gum a good texture and taste, and this effect is significantly better than the effect of using only one or several of them.

Experimental example 2

Dissolution test of sublingual tablets

The sublingual tablets provided by Examples 9-12 are used as Experimental Examples 1-4, and the sublingual tablets provided by Comparative Examples 13-16 are used as Experimental Examples 1-4. "Turning Basket Method", one of the drug testing methods, measures the dissolution rates of each group of sublingual tablets, and the specific testing methods are as follows:

Use deionized water as the dissolution medium, heat to about 41°C, and stir continuously for more than 5 minutes under vacuum conditions to obtain a degassed dissolution medium; measure the deionized water that has been degassed, and place it in 8 dissolution cups. After the temperature of the dissolution medium is constant at 37°C±0.5°C, take 6 pieces of samples from each group, put them into 6 dry baskets, and lower the baskets into the dissolution cups. Be careful not to have any Bubbles, start the dissolution apparatus and adjust to 100r/min, record the time for each sample to dissolve completely, and compare the dissolution rate of each group of samples.

The complete dissolution time of each group sublingual tablet of table 2

As can be seen from Table 2, the dissolution times of the experimental groups 1-4 were significantly lower than those of the control groups 1-4, indicating that the dissolution rates of the experimental groups were significantly higher than those of the control groups. Sublingual tablets should dissolve quickly under the tongue when used, and the drug is absorbed through the sublingual mucosal capillaries and transported to the whole body by the blood to achieve therapeutic effect. "Chinese Pharmacopoeia" 2010 edition stipulates that unless otherwise specified, sublingual tablets should be completely dissolved within 5 minutes. It can be seen that the dissolution time of the sublingual tablets in the experimental groups 1-4 all met the national standard. Therefore, the combined use of fillers of isomalt + sorbitol + α-lactose + microcrystalline cellulose can make the sublingual tablet have a good dissolution effect, and this dissolution effect is significantly better than using only one of them or individually The effect of several times.

Experimental example 3

Clinical Trials of Diabetic Complications

1. Test case

A total of 160 diabetic patients aged between 30 and 60 were selected and randomly divided into 8 groups, 20 people in each group. None of the patients were pregnant or lactating.

2. Dosage

Take the composition provided in Example 1-4 as experimental group 1-4, take the composition provided in Comparative Example 5-8 as control group 5-8, let 8 groups of patients take the above 8 groups of products respectively, every 12 hours 1 time, 1g each time, at the same time, inject insulin according to the amount prescribed by the doctor, once every 12 hours, and treat continuously for 60 days.

3. Evaluation indicators

Clinical manifestations: weakness of limbs, numbness of hands and feet, proteinuria, dry eyes, blurred vision, arrhythmia

Physiological and biochemical indicators: urinary microalbumin content of diabetic patients >20mg/L.

Significantly effective: After treatment, the symptoms of the disease were significantly improved, and the urine microalbumin dropped to the normal range (<18.14mg/L);

Effective: After treatment, the symptoms of the disease were improved, and the urine microalbumin was significantly reduced and maintained at a relatively stable state;

Ineffective: no significant changes before and after treatment.

4. Data processing

The clinical data of the patients were collated and analyzed, and the treatment effects of the experimental group and the control group were compared by t test.

5. Experimental results

Table 3 Treatment of patients in each group

There was a significant difference between the experimental group and the control group (p<0.05).

6. Analysis and conclusion

It can be seen from Table 3 that the effective rate of the experimental group is not less than 85%, while the effective rate of each group of the control group is not more than 65%, indicating that the curative effect of the experimental group is significantly higher than that of the control group. And the follow-up investigation shows that some patients in the control group have recurrence signs such as blurred vision and numbness of hands and feet within one year after taking the medicine, while all patients in the experimental group have no adverse reactions or signs of recurrence within one year after taking the medicine, which shows that the drug provided by the embodiments of the present invention The composition has good therapeutic effect on diabetic complications, has long-lasting effect and no toxic or side effect, and is suitable for popularization.

Experimental example 4

Hypertension Clinical Trials

1. Test case

A total of 160 hypertensive patients aged between 30 and 60 were selected and randomly divided into eight groups, 20 people in each group. None of the patients were pregnant or lactating.

2. Dosage

Take the composition provided in Example 1-4 as experimental group 1-4, take the composition provided in Comparative Example 1-4 as control group 1-4, let eight groups of patients take the above eight groups of products respectively, every 12 hours 1 time, 1g each time, for 30 consecutive days.

3. Evaluation indicators

Clinical manifestations: dizziness, headache, nervousness, inattention, memory loss, limb numbness, palpitations, chest tightness, fatigue, etc.

Physiological and biochemical indicators: systolic blood pressure ≥ 140mmHg and diastolic blood pressure ≥ 90mmHg in hypertensive patients.

Significantly effective: After treatment, the symptoms of the disease improved significantly, and the blood pressure dropped to the normal range;

Effective: After treatment, the symptoms of the disease improved, and the blood pressure value was significantly reduced and maintained at a relatively stable state;

Ineffective: no significant changes before and after treatment.

4. Data processing

The clinical data of the patients were collated and analyzed, and the treatment effects of the experimental group and the control group were compared by t test.

5. Experimental results

Table 4 Treatment of patients in each group

There was a significant difference between the experimental group and the control group (p<0.05).

6. Analysis and conclusion

It can be seen from Table 4 that the effective rate of the experimental group is not less than 90%, while the effective rate of each group of the control group is not more than 70%, indicating that the curative effect of the experimental group is significantly higher than that of the control group. And the follow-up investigation shows that some patients in the control group have recurrence signs such as dizziness, chest tightness, limb numbness, and elevated blood pressure within half a year after taking the medicine, while all patients in the experimental group have no adverse reactions or signs of recurrence within half a year after taking the medicine, which shows that the present invention The composition provided in the example has a good therapeutic effect on hypertension, has a long-lasting effect and no side effects, and is suitable for popularization.

The above-mentioned embodiments only express several implementation modes of the present invention, and the description thereof is relatively specific and detailed, but should not be construed as limiting the patent scope of the present invention. It should be pointed out that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent for the present invention should be based on the appended claims.

Claims (10)

1. A composition for auxiliary treatment of hypertension and diabetes, characterized in that the composition comprises the following components in parts by weight: 40-60 parts of potassium chloride, 80-120 parts of lecithin, 240-240 parts of sugar 360 parts and 2.4 to 3.6 parts of magnesium chloride, the sugar is selected from at least one of glucose, fructose, maltose or sucrose. 2 . The composition for auxiliary treatment of hypertension and diabetes according to claim 1 , further comprising 24-36 parts by weight of metformin. 3 . 3. A preparation for auxiliary treatment of hypertension and diabetes, comprising the composition according to claim 1 or 2, characterized in that the preparation is selected from chewing gum, sublingual tablet, hard candy, spray or mixture. 4. The preparation for auxiliary treatment of hypertension and diabetes as claimed in claim 3, characterized in that, the preparation is chewing gum, and the chewing gum comprises the following ingredients in parts by weight: 15-25 parts of the composition, 20-35 parts of gum base, 5-10 parts of plasticizer. 5. the preparation for auxiliary treatment of hypertension, diabetes as claimed in claim 4, is characterized in that, described gum base is the mixture of konjac gum, polyvinyl acetate and Eucommia gum, and described konjac gum, polyvinyl acetate The weight-number ratio of the ester and the Eucommia gum is 1-2:2:1. 6. the preparation for auxiliary treatment of hypertension, diabetes as claimed in claim 4, is characterized in that, described plasticizer is the mixture of beeswax, candelilla wax and methyl acetyl ricinoleate, and The ratio of parts by weight of beeswax, candelilla wax and methyl acetyl ricinoleate is 1:1:1-2. 7. The preparation for auxiliary treatment of hypertension and diabetes as claimed in claim 3, characterized in that, the preparation is a sublingual tablet, and the sublingual tablet comprises the following components in parts by weight: the composition 20 ～30 parts, 50～70 parts of filler and 0.6～1 part of lubricant. 8. The preparation for auxiliary treatment of hypertension and diabetes as claimed in claim 7, wherein the filler is a mixture of isomalt, sorbitol, α-lactose and microcrystalline cellulose, and the The weight ratio of isomalt, sorbitol, α-lactose and microcrystalline cellulose is 1:1:2:2～4; preferably, the lubricant is magnesium stearate, glyceryl behenate And the mixture of magnesium lauryl sulfate, the weight and number ratio of the magnesium stearate, glyceryl behenate and magnesium lauryl sulfate is 1-3:1:1. 9. The preparation for auxiliary treatment of hypertension and diabetes according to claim 3, characterized in that, the preparation is hard candy, and the hard candy comprises the following components in parts by weight: the composition 20～ 30 parts, 10-15 parts of honey, 10-15 parts of steviol glycoside, 3-5 parts of mint, 3-5 parts of concentrated lemon juice and 0.01 part of compound trace elements, which include chromium picolinate, glucose Zinc Oxide, Ferric Citrate, Manganese Sulfate, Copper Sulfate, and Cobalt Sulfate. 10. The application of the composition for auxiliary treatment of hypertension and diabetes described in claim 1 or 2 in the preparation of medicines for auxiliary treatment of hypertension and diabetes.