CN106310539A - Phototherapy device applied to metabolic diseases - Google Patents

Abstract

The invention relates to a phototherapy device applied to metabolic diseases. The phototherapy device is provided with a flexible panel, the flexible panel is ring-shaped, and is provided with a wearing gap. Semiconductor light-emitting diodes arranged in a shape, the outer wall of the flexible panel is provided with a control unit integration device, and the two ends of the flexible panel are provided with fixed belts that match each other. The semiconductor light-emitting diodes are driven by PWM pulses, and the output is Ultraviolet light, blue light, yellow-green light, orange-red light or a combination of two or more of the above light colors. The phototherapy device of the present invention has a simple overall structure, strong pertinence, good portability, and is easy to use. It can emit a light group with a certain intensity and wavelength that has a therapeutic effect, and provides comfortable and safe treatment for patients with metabolic diseases.

Description

A phototherapy device applied to metabolic diseases

technical field

The invention relates to the technical field of medical devices, in particular to a phototherapy device applied to metabolic diseases.

Background technique

Mechanism research and treatment plan exploration of human metabolic diseases has always been a research hotspot in the medical field. Metabolic diseases include hyperthyroidism, hyperparathyroidism, diabetes, kidney disease, orthopedic diseases, etc. Currently, the more common treatment measures include drug therapy and surgical therapy. However, these treatment methods have the disadvantages of inconvenient use, high medical costs, and relatively large side effects.

Semiconductor light emitting diodes (Light Emitting Diode, LED) have attracted the most attention among various new light sources in recent years. Because LED devices have the characteristics of safety and long life, compact structure, easy control, wide spectrum coverage and natural and comfortable cold light source, they not only shine in the field of general lighting applications, but also have great potential in the fields of display, agriculture and medical applications. ,Broad prospects. In the medical field, the current application direction mainly includes: LED red light and infrared light are used in the skin medical field of female stretch marks, surgical wound and tissue healing, facial acne, etc.; LED blue light is used to treat seasonal depression (SeasonalAffective Disorder, SAD), periodontal disease, etc. Correspondingly, some phototherapy devices have appeared. For example, Chinese patent document CN200510082164.4, published on November 29, 2006, discloses a dental lighting system, which includes an adjustable self-supporting frame and a lamp head, and the lamp head is connected to the frame On; the lamp head includes a housing and a barrier body with some structures, the barrier body is suitable for mechanically detachable coupling the lamp head and a reference device, so as to use the light source arranged in the lamp head to align the teeth perform lighting; the barrier body and the lamp cap can be made into one; if the two parts are made separately, some structures can be provided on the lamp cap and each barrier body; the lamp system includes at least one light source, which is Selected from a group of light sources, this group of light sources includes halogen bulbs, semiconductor light-emitting devices, light-emitting chips, LED arrays, fluorescent tubes and their combinations; Chinese patent document CN200910063623.2, published on 2011.03.30, disclosed A semiconductor narrow-spectrum gynecological disease treatment instrument, including two parts: a main unit and a treatment head. The main unit is composed of a control system, a power supply system, and a cooling system. 1. The installation bracket is assembled from front to back to form a cylindrical energy-concentrating treatment head with a spherical head. The energy-concentrating treatment head is connected to the host through a light source electrode and a cooling water pipe. The length of the light source output by the light source electrode is 600- 650nm; the treatment head is also a kind of scattering treatment head with a cylindrical head that is assembled from a light guide cover, a semiconductor light-emitting tube, and a mounting bracket from front to back. The light source is passed between the scattering treatment head and the host. The electrodes are connected, and the installation bracket arranges the light source evenly in strips around the bracket, and the length of the light source output by the light source electrode is 600-650nm.

However, for some metabolic diseases such as hyperthyroidism and partial knee osteoporosis, there is currently no semiconductor light-emitting diode phototherapy device with strong therapeutic pertinence, outstanding effect, and ease of use.

Contents of the invention

The object of the present invention is to provide a phototherapy device applied to metabolic diseases to address the deficiencies in the prior art.

For realizing above-mentioned object, the technical scheme that the present invention takes is:

A phototherapy device applied to metabolic diseases, the phototherapy device is provided with a flexible panel, the flexible panel is ring-shaped, and is provided with a wearing gap, and the inner wall of the flexible panel is arranged in an array. The semiconductor light-emitting diode, the outer wall of the flexible panel is provided with a control unit integration device, and the two ends of the flexible panel are provided with matching fixing belts.

The flexible panel is in the shape of a ring or an ellipse under no external force.

The flexible panel is a flexible rubber plate.

The semiconductor light-emitting diodes are driven by PWM pulses.

The semiconductor light-emitting diode emits ultraviolet light, blue light, yellow-green light, orange-red light or a combination of two or more light colors.

The fixing belt is a lace, a Velcro and a hook buckle or a Japanese word buckle with adjustable length.

The metabolic disease is hyperthyroidism, hyperparathyroidism, type I diabetes, type II diabetes, gestational diabetes, chronic kidney disease, fracture or osteoporosis.

The present invention has the advantage that:

1. The shape design of the phototherapy device of the present invention and the design of the arrangement of semiconductor light-emitting diodes are very reasonable, and can be given to some metabolic diseases such as hyperthyroidism, partial knee osteoporosis and other optical treatments, with more pertinence and more prominent therapeutic effects ;

2. The shape of the phototherapy device of the present invention is variable, easy to wear, adjustable, and can be applied to different patients or different diseased parts;

3. The semiconductor light-emitting diodes are driven by PWM pulses, which ensures the safety of the temperature rise of the phototherapy device of the present invention under the premise of ensuring the therapeutic effect.

Description of drawings

Accompanying drawing 1 is a structural schematic diagram of the phototherapy device of the present invention.

Accompanying drawing 2 is the waveform diagram of the PWM pulse driving mode of the semiconductor light emitting diode.

detailed description

The specific embodiments provided by the present invention will be described in detail below in conjunction with the accompanying drawings.

The reference signs and components involved in the accompanying drawings are as follows:

1. Flexible panel 2. Wearing notch

3. Semiconductor light-emitting diode 4. Control unit integrated device

5. Fixing strap

Embodiment 1 Phototherapy device of the present invention

Please refer to FIG. 1 , which is a schematic structural diagram of the phototherapy device of the present invention. The phototherapy device is provided with a flexible panel 1 , and the flexible panel 1 is ring-shaped without external force, and is provided with a wearing gap 2 . Semiconductor light emitting diodes 3 are arranged on the inner wall of the flexible panel 1, and the semiconductor light emitting diodes 3 are arranged in an array. A control unit integration device 4 is provided on the outer wall of the flexible panel 1 . Both ends of the flexible panel 1 are provided with matching fixing straps 5 .

Please refer to FIG. 2 . FIG. 2 is a schematic waveform diagram of a PWM pulse driving mode of a semiconductor light emitting diode. Due to the limitation of LED heat dissipation technical conditions, the temperature rise of LEDs driven by constant current is serious, resulting in the surface temperature of the phototherapy device far exceeding the safety upper limit temperature stipulated by relevant national regulations under a certain output light power density. The use of PWM pulse drive can effectively solve this problem. According to needs, the pulse cycle frequency can be set higher than the fusion frequency of human eyes, so that the patient has the same perception of the output light under the two driving modes. Under the current pulse signal, the peak optical power density of the phototherapy device is not lower than the average optical power density output value under the constant current driving mode, so as to ensure the same or even better therapeutic effect. At the same time, a low duty cycle method can be adopted, that is, in a cycle, it is actually in a non-working state for a long time (within the t2 time period), which greatly reduces the heat dissipation requirements of the device.

It should be noted that the flexible panel 1 is a flexible and deformable structure, which is ring-shaped under natural and no external force, and is provided with a wearing gap 2, so it can be fixed on different patient parts such as neck and knee Optical therapy can fit well with the patient's treatment site, which is more targeted and the treatment effect is more prominent. The ring shape can be circular or elliptical. The material of the flexible panel 1 includes but not limited to a flexible rubber sheet. The semiconductor light-emitting diodes 3 are arranged in an array, so that the light given to the diseased part is uniform, so as to improve the therapeutic effect. The control unit integration device 4 is used to control parameters such as the irradiation time, irradiation intensity and driving mode of the semiconductor light emitting diode 3 . The fixing belt 5 is used to fix the phototherapy device of the present invention on the patient's part, such as the neck position or the knee position, and the fixing belt 5 can be a lace, a Velcro and hook buckle, and a Japanese character buckle with adjustable length, etc. , easy to adjust, applicable to different patients and different diseased parts.

For the semiconductor light-emitting diode 3, its spectral composition, light intensity, light angle, driving mode, etc. can be flexibly depended on the treatment scene; its spectral composition is not limited, including but not limited to ultraviolet light, blue light, yellow-green light, orange-red light and the above-mentioned light colors An organic combination, wherein the ultraviolet light has a spectral peak at a wavelength in the wavelength range of 280nm to 435nm, the monochromatic blue light has a spectral peak at a wavelength in the wavelength range of 435nm to 500nm, and the yellow-green light has a spectral peak at a wavelength in the wavelength range of 500nm to 500nm There is a spectral peak at a wavelength in the wavelength range of 600nm, and the orange-red light has a spectral peak at a wavelength in the wavelength range of 600nm to 780nm; its driving mode is not limited to this embodiment, including constant current driving and PWM pulse driving Correspondingly, the light source emits in a continuous form or in a pulsed form; its light output intensity is not limited, and the average irradiance of the irradiated skin surface can be flexibly changed, specifically 0mW/cm ² to 100mW/cm ² ; its light output The angle is not limited, including extremely narrow exit beam angles for fixed-point irradiation, and wider exit beam angles for large-area irradiation.

The phototherapy device of the present invention has a simple overall structure, strong portability, and is easy to use. It can emit a light group with a certain intensity and wavelength that has a therapeutic effect, and provides comfortable and safe treatment for patients with metabolic diseases. Diseases include but are not limited to hyperthyroidism, hyperparathyroidism, type I diabetes, type II diabetes, gestational diabetes, chronic kidney disease, fractures, osteoporosis, and various metabolic diseases that are not currently defined accurately.

Embodiment 2 Application of phototherapy device of the present invention to treat diabetes

30 cases of diabetes were divided into three groups, 10 people in each group, and the phototherapy device of the present invention was used to give phototherapy. The light source for phototherapy in group A was ultraviolet LED with a peak wavelength of 340nm, the light source for group B was blue LED with a peak wavelength of 430nm, and the light source for group C was red LED with a peak wavelength of 635nm. Before receiving phototherapy, the average random blood glucose concentration of the patient was 17.5mmol/L, and the average fasting blood glucose concentration was 9.8mmol/L. After a 14-day period of 30 minutes of optical therapy per day, the random blood glucose concentration of patients in group A was 14.9mmol/L, and the fasting blood glucose concentration was 8.4mmol/L; the random blood glucose concentration of patients in group B was 12.8mmol/L , the fasting blood glucose concentration was 7.5mmol/L; the random blood glucose concentration of patients in group C was 17.3mmol/L, and the fasting blood glucose concentration was 9.5mmol/L. It can be seen that the treatment effect of group B is the best. In addition, the patients in group A and group B also generally expressed relief of dizziness and improved sleep quality, while group C did not. Therefore, the significant improvement of each characteristic index proves the effectiveness of phototherapy for the treatment of diabetes, a metabolic disease, and the treatment effect of blue LED is the best.

Embodiment 3 Application of phototherapy device of the present invention to treat hyperthyroidism

Divide 18 cases of hyperthyroidism into three groups, 6 people in each group, and give optical therapy. The light source for phototherapy in group A was ultraviolet LED with a peak wavelength of 340nm, the light source for group B was blue LED with a peak wavelength of 430nm, and the light source for group C was red LED with a peak wavelength of 635nm. Before receiving phototherapy, the average total T3 concentration of the patient was 3.75nmol/L, the average total T4 concentration was 185nmol/L, the average free T3 concentration was 13.53pmol/L, and the average free T4 concentration was 28pmol/L . After a 30-day period of 20 minutes of optical therapy per day, the average total T3 concentration of patients in group A was 3.13nmol/L, the average total T4 concentration was 166nmol/L, and the average free T3 concentration was 11.77pmol/L , the average free T4 concentration was 23pmol/L; the average total T3 concentration of patients in group B was 2.84nmol/L, the average total T4 concentration was 154nmol/L, the average free T3 concentration was 10.64pmol/L, the free T4 The average concentration was 22pmol/L; the average total T3 concentration of patients in group C was 3.64nmol/L, the average total T4 concentration was 179nmol/L, the average free T3 concentration was 13.28pmol/L, and the average free T4 concentration It is 27pmol/L, it can be seen that the treatment effect of group B is the best. In addition, patients in group A and group B also generally expressed hand tremor, sweating, heart palpitations, emotional irritability, and polyphagia, while only some patients in group C had similar feelings. Therefore, the significant improvement of each characteristic index proves the effectiveness of phototherapy for the treatment of hyperthyroidism, a metabolic disease, and the treatment effect of blue LED is the best.

Embodiment 4 Application of phototherapy device of the present invention to treat osteoporosis

Optical therapy was administered to 100 cases of severe osteopenia (T-score between -2.0 and -2.5). Among them, 60 cases belonged to the irradiation group, which were divided into three groups with 20 people in each group. The light source for phototherapy in group A was ultraviolet LED with a peak wavelength of 340nm, the light source for group B was blue LED with a peak wavelength of 430nm, the light source for group C was red LED with a peak wavelength of 635nm, and the other 60 cases The unirradiated group was used as a control. After receiving a 45-minute daily phototherapy session for a period of 6 months, the average bone loss of patients in the non-irradiated group was 38%, and the average bone loss in patients in the irradiated group was 23%. Specifically, among the irradiation groups, the bone loss rate of group B was the lowest. In addition, the patients in the irradiated group generally expressed that their backaches and backaches were relieved, and their sleep quality improved.

Embodiment 5 Application of phototherapy device of the present invention to treat chronic kidney disease

Optical therapy was given to 24 chronic kidney disease cases. Among them, 12 cases belonged to the irradiation group and were divided into three groups with 4 people in each group. The light source for phototherapy in group A was ultraviolet LED with a peak wavelength of 340nm, the light source for group B was blue LED with a peak wavelength of 430nm, the light source for group C was red LED with a peak wavelength of 635nm, and the other 12 cases The unirradiated group was used as a control. After receiving the 20-minute phototherapy course every day for 2 months, the average glomerular filtration rate of patients in the non-irradiated group was 58ml·min-1·1.73m ² , and the average glomerular filtration rate of patients in the irradiated group The yield is 89ml·min-1·1.73m ² . Specifically, in the irradiation group, the mean glomerular filtration rate of group B is the highest. The significant improvement of the characterization indicators proves the effectiveness of phototherapy in the treatment of chronic kidney disease, a metabolic disease, especially the important effect of blue light.

The above is only a preferred embodiment of the present invention, it should be pointed out that for those of ordinary skill in the art, without departing from the method of the present invention, some improvements and supplements can also be made, and these improvements and supplements should also be considered Be the protection scope of the present invention.

Claims (7)

1. A phototherapy device applied to metabolic diseases, characterized in that, the phototherapy device is provided with a flexible panel, the flexible panel is ring-shaped, and is provided with a wearing gap, and the inner wall of the flexible panel is provided with a flexible panel. There are semiconductor light-emitting diodes arranged in an array, a control unit integration device is provided on the outer wall of the flexible panel, and fixed belts that match each other are provided at both ends of the flexible panel. 2. The phototherapy device according to claim 1, wherein the flexible panel is in the shape of a ring or an ellipse without external force. 3. The phototherapy device according to claim 1, wherein the flexible panel is a flexible rubber plate. 4. The phototherapy device according to claim 1, characterized in that, the semiconductor light-emitting diodes are driven by PWM pulses. 5 . The phototherapy device according to claim 1 , wherein the semiconductor light emitting diodes emit ultraviolet light, blue light, yellow-green light, orange-red light or a combination of two or more light colors. 6 . The phototherapy device according to claim 1 , wherein the fixing belt is a lace, a Velcro and hook buckle, or a sun-shaped buckle with adjustable length. 7 . 7. The phototherapy device according to claim 1, wherein the metabolic disease is hyperthyroidism, hyperparathyroidism, type I diabetes, type II diabetes, gestational diabetes, chronic kidney disease, fracture or osteoporosis .