CN106309849A - Tibetan medicine compound for foot bath and application thereof - Google Patents

Abstract

The invention discloses a Tibetan medicine compound for foot bath and an application thereof. The Tibetan medicine compound comprises juniper, wood of shiny-leaved yellowhorn, artemisia sieversiana, rhododendron anthopogonoide, ephedra, myricaria germanica, caulis sinomenii, erigeron breviscapus, geranium wilfordii, rhizoma dioscoreae nipponicae, homalomena occulta and saussurea involucrate. After the Tibetan medicine compound is applied to foot bath, the effect of dispelling wind, eliminating dampness and promoting blood circulation to remove meridian obstruction can be enhanced. The Tibetan medicine compound is capable of reinforcing liver and kidney and promoting immunity and has excellent effects at the aspects of treating rheumatic arthritis, chronic infectious arthritis, hemiplegia, gout, and the like.

Description

A kind of foot bath Tibetan medicinal composition and application thereof

Technical field

The present invention relates to a kind of foot bath Tibetan medicinal composition and the application in terms for the treatment of arthromyodynia thereof, belong to biological medicine skill Art field.

Background technology

Numbness disease refers to positive QI-insufficiency, the exopathogen such as wind, cold, wet, heat invasion and attack human body, and numbness resistance meridians, QI-blood circulation is the most freely led The disease caused.Pyretic arthralgia is with the invasion and attack of rheumatism pathogenic heat or wind-cold damp pathogen is strongly fragrant and a type that heat-transformation is caused, with redness and swelling of joints heat Bitterly, joint stuffiness is main clinical manifestation.

Primary disease is that pathogen numbness hinders meridians, and QI-blood circulation is not smooth caused, therefore eliminating evil treatment active, that relieving spasm to stop pain is primary disease is former Then.Because pathogen is miscellaneous extremely, dispel the wind, cold expelling, dehumidifying, heat clearing away, eliminate the phlegm, the method for the treatment of such as disperse blood stasis and dredge collateral should mutually be taken into account, because pathogen has victory partially, Eliminating evil dredging collateral is respectively arranged with again emphasis.

Tibet-medicine Bath is recorded in Tibetan medicine's classics book Four-Volume Medical Code the earliest, the most history in 1300." four doctors Allusion quotation " described in follow-up portion, " every orthocolosis, scrofula, furuncle, new and old wound, swelling, hunchback, kindred grasserie, all are grand Type disease etc., can medication water dipping bath therapy treat ".

Foot bath can promote qi-blood circulating, coordinates the foot bath medicinal liquid that different pharmaceutical is made, by the warm-heat effect of water and borrow Helping medicine steam and medicinal liquid to smoke the therapeutical effect washed, its heating power more can help the efficacy of a drug to permeate, have toxin expelling, circulation of qi promoting, invigorate blood circulation, subside a swelling, Dissipating blood stasis, body-building hold concurrently diseases prevention, strengthen function of human body effect.

Summary of the invention

The invention provides a kind of foot bath Tibetan medicinal composition and the application in terms for the treatment of arthromyodynia thereof, use the present invention's Foot bath Tibetan medicinal composition, can strengthen the effect of its expelling wind and removing dampness promoting blood circulation to remove obstruction in the collateral, at treatment rheumatic arthritis, rheumatoid joint The aspects such as inflammation, hemiplegia, gout have good effect.

Technical scheme is as follows:

A kind of foot bath Tibetan medicinal composition, weight portion composition is as follows:

Juniperus oxycedrus 100-140 part, wood of shiny-leaved yellowhorn 80-120 part, Artemisia sieversiana Willd. 40-80 part, Rhododendron 80-120 part, Herba Ephedrae 80- 120 parts, Cacumen Myricariae Germanicae 80-120 part, Caulis Sinomenii 60-100 part, Herba Erigerontis 60-100 part, Herba Erodii 40-80 part, Rhizoma Dioscoreae Nipponicae 80- 120 parts, Rhizoma Homalomenae 30-70 part, Herba Saussureae Involueratae 30-70 part.

Currently preferred, weight portion composition is as follows:

Juniperus oxycedrus 120 parts, wood of shiny-leaved yellowhorn 100 parts, Artemisia sieversiana Willd. 60 parts, Rhododendron 100 parts, 100 parts of Herba Ephedrae, Cacumen Myricariae Germanicae 100 parts, Caulis Sinomenii 80 parts, Herba Erigerontis 80 parts, Herba Erodii 60 parts, Rhizoma Dioscoreae Nipponicae 100 parts, Rhizoma Homalomenae 50 parts, Herba Saussureae Involueratae 50 parts.

Above 12 tastes, are ground into coarse powder, sieve, mixing, to obtain final product.

The present invention is medicine for external use, and usage is: takes coarse powder 100g and decocts soup (add 5L water, decoct 20min, filter) and pour foot-bathing bucket into In, or coarse powder is ground into fine powder (100 mesh), pour into and foot-bathing bucket adds the immersion of 5L boiled water, enter when water temperature is down to 37 DEG C-42 DEG C Row foot bath, every day 1 time, every time no less than 15 minutes.There is expelling wind and removing dampness, blood stasis dispelling, detumescence, effect of pain relieving.For rheumatic fever Evil numbness resistance redness and swelling of joints burning pain caused by meridians, joint stuffiness；Rheumatic arthritis, rheumatoid close inflammation joint, osteoarthritis is shown in Above-mentioned patient.

Each crude drug source and effect are as follows:

Juniperus oxycedrus: Cupressaceae Juniperus oxycedrus Juniperus taiwaniana Hayata, epith mut., root is used as medicine.Bitter；Cold in nature. Heat-clearing and toxic substances removing；Dampness removing to stop itchin, for rash high warm；Eczema；Tinea skin ulcer.

Cacumen Myricariae Germanicae: Cacumen Tamaricis section Myricaria plant Cacumen Myricariae Germanicae Myricaria germanica (L.) Desv., enters with sprout Medicine.Acrid, sweet, warm.Dispelling wind, induces sweat, rash, cough-relieving, heat-clearing and toxic substances removing, for measles without adequate eruption.

Herba Ephedrae: Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf, epheday intermedia Ephedra intermedia Schrenk et C.A.Mey. or the dry herb stem of ephedra equisetina Ephedra equisetina Bge..Hardship pungent, micro-, temperature, Diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema, for anemofrigid cold, uncomfortable in chest breath with cough, edema due to wind pathogen edema

Rhododendron: ericad Rhododendron Rhododendron anthopogonoides Maxim. hair larynx Cuculus polioephalus Rhododendron cephalanthum Franch. and flower-shaped Cuculus polioephalus Rhododendron of heralding spring The dry Hua Heye of primulaeflarum Bur.et Franch..Sweet, puckery, flat, clearing heat for detumescence, the kidney invigorating, for tracheitis, Emphysema, edema, physical weakness and water and soil are uncomfortable, and dyspepsia, gastroptosis, flatulence, skin ulcer pestilence is controlled in external.

Artemisia sieversiana Willd.: Compositae Artemisia sieversiana Willd. Artemisia sieversiana Willd., is used as medicine with alabastrum.Micro-sweet, bitter, cold, Heat-clearing and toxic substances removing, detumescence hemostasis, profit kidney, for extremities joint swelling, bitterly furuncle, sarcoma, pneumonopathy, nephropathy and spitting of blood, epistaxis.

Herba Saussureae Involueratae: Compositae Herba Saussureae Involueratae Pittosporum Herba Saussureae Involueratae (formal name used at school: Saussurea involucrata (Kar.et Kir.) Sch.-Bip.), pungent, bitter, flat, warming the kidney to activate YANG, expelling wind and dampness, restore menstrual flow and invigorate blood circulation, for rheumatic arthralgia, rheumatoid arthritis is little Abdomen cold type of pain, menoxenia.

Wood of shiny-leaved yellowhorn: the dry stem of sapindaceous plant wood of shiny-leaved yellowhorn Xanthoceras sorbifolia Bunge.It is cool, Puckery, reducing swelling and alleviating pain, dry blood, yellow fluid reducing, for rheumatic arthritis, rheumatism interior-heat, leprosy.

Rhizoma Dioscoreae Nipponicae: Dioscoreaceae plant Dioscorea nipponica Mak. Ningpo Yam Rhizome and the rhizome of bavin Dioscorea zingiberensis.Warm in nature, sweet in the mouth, hardship, relaxing muscles and tendons to promote blood circulation, cough-relieving Expectorant, wind-expelling pain-stopping, for lumbago and skelalgia, rheumatalgia, rheumatic arthritis, muscles and bones numbness, Kaschin-Beck disease, traumatic injury, sprain one's back, cough Cough pant, tracheitis, bronchitis.

Rhizoma Homalomenae: the dry rhizome of aroid Rhizoma Homalomenae Homalomena occulta (Lour.) Schott. Bitter, pungent, temperature, wind-damp dispelling, bone and muscle strengthening, for rheumatic arthralgia, chills and pain of the waist and kness, contracture is numb, and muscles and bones is withered soft.

Herba Erodii: Huai Niuer Seedling section's plant cattle Seedling or Herba Erodii, nepal cranesbill, Siberia geranium and open country Herba Erodii, tuber person stork grass etc. are with the herb of fruit.Pungent, bitter, flat, wind-damp dispelling, the meridian dredging, antidiarrheal dysentery, for rheumatic arthralgia, Numbness contracture, muscles and bones aches, dysentery

Herba Erigerontis: Compositae Herba Erigerontis aceris platymiscium Erigeron breviscapus (Vant.) Hand.-Mazz. Erigeron breviscapus (Vaniot) Hand.- Mazz., it is used as medicine with herb or root.Hardship pungent, micro-, temperature, promoting blood circulation, dredging meridian and relieving pain, expelling wind and cold, for apoplectic hemiplegia, obstruction of qi in the chest and cardialgia, Rheumatism disadvantage, headache, toothache.

Caulis Sinomenii: menispermaceous plants Sinomenium acutum (Sinomenium acutum (Thunb.) Rehd et Wils.) and hair Sinomenium acutum The dry rattan of (Sinomenium acutum (Thunb.) Rehd.et Wils.var.cinereum Rehd.et Wils.). Bitter, pungent, flat, wind-damp dispelling, the meridian dredging, diuresis, for rheumatic arthralgia, arthroncus, benumb pruritus.

Beneficial effect: we, on the basis of the basic prescription " five tastes manna dipping soup dissipates " of Tibet-medicine Bath, add Wen Guan Wood, Caulis Sinomenii, Herba Erigerontis, Herba Erodii, Rhizoma Dioscoreae Nipponicae, Rhizoma Homalomenae, Herba Saussureae Involueratae seven flavor medicine material, enhance its expelling wind and removing dampness and invigorate blood circulation The effect of dredging collateral, hold concurrently with invigorating the liver and kidney reinforcing body resistance, agree with this disease pathogenesis, treat rheumatic arthritis, rheumatoid arthritis, The aspect such as hemiplegia, gout has good effect.

Detailed description of the invention:

Below by specific embodiment, the present invention will be further elaborated, and the description below is merely to explain this Bright, its content is not defined.

Embodiment 1:

Take Juniperus oxycedrus 120g, wood of shiny-leaved yellowhorn 100g, Artemisia sieversiana Willd. 60g, Rhododendron 100g, Herba Ephedrae 100g, Cacumen Myricariae Germanicae 100g, bluish glaucoma Rattan 80g, Herba Erigerontis 80g, Herba Erodii 60g, Rhizoma Dioscoreae Nipponicae 100g, Rhizoma Homalomenae 50g, Herba Saussureae Involueratae 50g, above 12 tastes are ground into Coarse powder, sieves, mixing, to obtain final product.

Take coarse powder 100g and be ground into fine powder (100 mesh), pour into and foot-bathing bucket adds the immersion of 5L boiled water, treat that water temperature is down to 40 DEG C of left sides Foot bath is carried out time right, every day 1 time, each 15 minutes.

Embodiment 2:

Take Juniperus oxycedrus 100g, wood of shiny-leaved yellowhorn 90g, Artemisia sieversiana Willd. 60g, Rhododendron 110g, Herba Ephedrae 120g, Cacumen Myricariae Germanicae 80g, Caulis Sinomenii 70g, Herba Erigerontis 80g, Herba Erodii 70g, Rhizoma Dioscoreae Nipponicae 120g, Rhizoma Homalomenae 30g, Herba Saussureae Involueratae 40g, above 12 tastes are ground into slightly Powder, sieves, mixing, to obtain final product.

Take coarse powder 100g to decoct soup (add 5L water, decoct 20min, filter) and pour in foot-bathing bucket, treat that water temperature is down to about 40 DEG C Shi Jinhang foot bath, every day 1 time, each 20 minutes.

Embodiment 3:

Take Juniperus oxycedrus 140g, wood of shiny-leaved yellowhorn 110g, Artemisia sieversiana Willd. 50g, Rhododendron 80g, Herba Ephedrae 120g, Cacumen Myricariae Germanicae 110g, bluish glaucoma Rattan 50g, Herba Erigerontis 60g, Herba Erodii 80g, Rhizoma Dioscoreae Nipponicae 110g, Rhizoma Homalomenae 40g, Herba Saussureae Involueratae 30g, above 12 tastes are ground into Coarse powder, sieves, mixing, to obtain final product.

Take coarse powder 100g and be ground into fine powder (100 mesh), pour into and foot-bathing bucket adds the immersion of 5L boiled water, treat that water temperature is down to 40 DEG C of left sides Foot bath is carried out time right, every day 1 time, each 30 minutes.

For checking the therapeutic effect of the present invention, spy carries out following experiment:

Experimental example 1: antiinflammatory action is studied

1. the impact on rat assist agent arthritis

Take rat 60, body weight 180 ± 20g, be randomly divided into 6 groups, respectively blank group, embodiment 1 group, embodiment 2 groups, embodiment 3 groups, five tastes manna dipping soup dissipate group, cortisone acetate group.Rat is under ether light anaesthesia, complete with Freund's Full adjuvant 0.1mL/ only (including bacillus calmette-guerin vaccine 7.5mg) is injected in right toes Intradermal and causes inflammation, and injection adjuvant started to be administered the same day, every day 1 time, successive administration 21d.Medication: blank group, embodiment 1 group, embodiment 2 groups, embodiment 3 groups and five tastes manna medicine Bath soup dissipate in group every rat suitably fixing after, metapedes and afterbody are immersed respectively tap water, 50g/L embodiment 1 group, embodiment 2 groups, embodiment 3 groups, 50g/L five tastes manna dipping soup dissipate group, 100ml/ only, 40 ± 2 DEG C, 30min；Cortisone acetate group, fills Stomach is administered, 0.05g/kg.Injection adjuvant is before and after spaced one and fixes the date, and by capillary tube measurement by magnification method, measures foot sole of the foot volume, gives Before and after adjuvant, the difference of volume is swelling degree, and result shows that novel composing prescription group antiphlogistic effects is better than five tastes manna dipping soup and dissipates group. The results are shown in Table 1.

The table 1 impact on rat assist agent arthritis

Compare with matched group: * p ＜ 0.05；* p ＜ 0.01

2. pair experimental arthritis inhibitory action

Take rat 60, body weight 180 ± 20g, be randomly divided into 6 groups, respectively blank group, embodiment 1 group, embodiment 2 groups, embodiment 3 groups, five tastes manna dipping soup dissipate group, cortisone acetate group, successive administration 8 days, after last is administered, by 1% fine jade It is subcutaneous that fat 0.1ml injects Rat Right toes, measures foot sole of the foot volume, calculate swollen after injecting proinflammatory agent after 1,2,6,24 hours Swollen degree, result shows, it is suitable that novel composing prescription group and five tastes manna dipping soup dissipate group antiinflammatory result.The results are shown in Table 2.

The table 2 impact on rat agar swelling

Compare with matched group: * p ＜ 0.05；* p ＜ 0.01

Experimental example 2: analgesic activity is studied

Take mice 90, male and female half and half, be randomly divided into 6 groups, respectively blank group, embodiment 1 group, embodiment 2 groups, Embodiment 3 groups, five tastes manna dipping soup dissipate group, aspirin group, successive administration 3 days, and after last is administered, 0.5h, 1.5h put mice Heat radiation induced pain on photo-thermal dolorimeter, with mice whipping for pain indicator reaction, record TFL (second), result shows, Novel composing prescription group analgesic effect is better than five tastes manna dipping soup and dissipates group.The results are shown in Table 3.

The table 3 inhibitory action to mice photo-thermal induced pain

Compare with matched group: * p ＜ 0.05；* p ＜ 0.01

Experimental example 3: the clinical observation on the therapeutic effect to rheumatoid arthritis

1 data and method

1.1 physical data

In selected 120 example patients, each 60 examples of men and women, age 20-66 year, the course of disease 6 months-30 years, inclusive criteria: meet class Rheumatic arthritis diagnostic criteria；There are arthroncus in various degree, osteoporosis, do not took related drugs in the recent period.Get rid of Standard: do not meet above-mentioned inclusive criteria；Merge the serious diseases such as the heart, brain, liver, kidney and hemopoietic system；Gestation or women breast-feeding their children, Psychotic etc..Using random digits table that selected patient is divided into two groups, often organize 60 examples, selected patient and family members are the most in the know Agree to this research.The physical data comparing difference not statistically significants (P > 0.05) such as two groups of Genders, age, the course of disease, state of an illness, There is comparability.

1.2 diagnosis of rheumatoid arthritis standards

The most generally use American Rheumatism Association's diagnostic criteria of 1987: refuse to budge (1) morning every day continuous at least 1h, continues At least 6 weeks；(2) there are 3 or the arthroncus of more than 3, continued at least 6 weeks；(3) wrist, metacarpophalangeal joints or proximal interphalangeal joint Swelling, continued at least 6 weeks；(4) symmetry arthroncus, continued at least 6 weeks；(5) hands X-ray film changes；(6) there is subcutaneous nodule； (7) rheumatoid factor positive (titre > 1:32).Above 7 possess 4 or more than 4 and can be diagnosed as rheumatoid joint Scorching.

1.3 Joint scores standards

I grade: daily routines are unrestricted；

II grade: the joint motion having moderate strength is limited, but daily routines needs can be met；

III grade: there is obvious limitation of activity in joint, patient can not be engaged in most of occupation or can not well take care of number one；

IV grade: LOM or be forced to lie in bed and maybe can only be sitting on wheelchair.

1.4X line is by stages

I phase: normal or joint end osteoporosis；

II phase: joint end osteoporosis, occasionally there is joint subchondral cyst sample to destroy or bone erosion changes；

III phase: significantly under articular cartilage, capsule destroys, and joint space is narrow, subluxation of joint deformity；

IV phase: in addition to II, III phase changed, and have fibroid or bony ankylosis.

1.5 Therapeutic Method

Advise patient's teetotalism during treatment, suitably reduce energy intake.Test group gives embodiment 1 group of powder, comparison Group gives five tastes manna dipping soup and dissipates, and treats 4 courses for the treatment of the most continuously for two groups, and 1 course for the treatment of is 7 days.

1.6 the standard of curative effect evaluation

Cure: clinical symptoms (pain, swelling deadlock in morning, function limitation etc.) and positive sign disappear, each joint movement function Recovering normal, take care of oneself, erythrocyte sedimentation rate is down to normally, follows up a case by regular visits to more than 1 year not recur.

Effective: clinical symptom relief, body weight increases, and each joint movement function part normal .X line of recovery is taken the photograph sheet and shown soft tissue Swelling disappears, and osteoporosis and bone destruction are stable, through following up a case by regular visits to more than 5 months without recurring and increasing the weight of.

Effective: pain and swelling alleviates, each joint movement function makes moderate progress, and erythrocyte sedimentation rate substantially changes.

Invalid: after treating for 1 course for the treatment of, each arthralgia is without taking a turn for the better.Total effective rate=cure rate+obvious effective rate+effective percentage.

1.7 observation index

Health giving quality observation index: (1) cardinal symptom: arthralgia, swelling, joint stuffiness, deadlock in morning and relevant performance； (2) mainly it is correlated with sign: articular pain index (articular pain number × articular pain degree), joint swelling index (arthroncus number × Articular swelling), function of joint, the average grip of both hands, the deadlock time in morning, pain (10cm horizontal vision synopsis method)；(3) reason Change and check: joint x-ray checks, erythrocyte sedimentation rate (ESR).

Safety indexes: (1) general health check-up item inspection；(2) hematuria routine examination；(3) hepatic and renal function inspection；(4) see Examine the untoward reaction being likely to occur.

1.8 statistical procedures

The data obtained uses SPSS software to carry out statistical analysis, represents that difference is statistically significant with P < 0.05.

2 results

2.1 comparitive study

Being showed no obvious untoward reaction during patient medication, medication Patients Before And After hepatic and renal function Testing index is all just In the range of Chang, 1 group of total effective rate of embodiment dissipates group higher than five tastes manna dipping soup.The results are shown in Table 4.

4 liang of table group comparitive study

Group	Number of cases	Effectively	Invalid	Effective percentage (%)
					Embodiment 1 group	60	53	7	88
Five-ingredient medicinal-bathing soup dissipates group	60	48	12	80

The prescription of embodiment 2 and embodiment 3 has also reached the curative effect that embodiment 1 is same.

Before and after 2.2 treatments, every observation index compares

Before patient's each index after treatment is superior to treat, comparing difference statistically significant (P < 0.05), wherein implement Example 1 group is better than five tastes manna dipping soup in terms of deadlock time in morning and erythrocyte sedimentation rate and dissipates group.The results are shown in Table 5.

Before and after the group treatment of 5 liang of table, every observation index compares

Compare with matched group: * p ＜ 0.05；* p ＜ 0.01

The prescription of embodiment 2 and embodiment 3 has also reached the index level that embodiment 1 is same.

Claims (5)

1. a foot bath Tibetan medicinal composition, it is characterised in that be made up of the medicine of following weight portion:

Juniperus oxycedrus 100-140 part；Wood of shiny-leaved yellowhorn 80-120 part；Artemisia sieversiana Willd. 40-80 part；Rhododendron 80-120 part；Herba Ephedrae 80-120 part； Cacumen Myricariae Germanicae 80-120 part；Caulis Sinomenii 60-100 part；Herba Erigerontis 60-100 part；Herba Erodii 40-80 part；Rhizoma Dioscoreae Nipponicae 80-120 part； Rhizoma Homalomenae 30-70 part；Herba Saussureae Involueratae 30-70 part.

Foot bath Tibetan medicinal composition the most according to claim 1, it is characterised in that be made up of the medicine of following weight portion:

Juniperus oxycedrus 120 parts, wood of shiny-leaved yellowhorn 100 parts, Artemisia sieversiana Willd. 60 parts, Rhododendron 100 parts, 100 parts of Herba Ephedrae, Cacumen Myricariae Germanicae 100 parts, bluish glaucoma 80 parts of rattan, Herba Erigerontis 80 parts, Herba Erodii 60 parts, Rhizoma Dioscoreae Nipponicae 100 parts, Rhizoma Homalomenae 50 parts, Herba Saussureae Involueratae 50 parts.

The foot bath Tibetan medicinal composition the most according to claim 1 and 2 application in the Pediluvium medicament of preparation treatment arthromyodynia.

The foot bath Tibetan medicinal composition the most according to claim 3 application in the Pediluvium medicament of preparation treatment arthromyodynia, its Being characterised by, described application process is as follows:

(1) take fully 12 taste medicines of bath Tibetan medicinal composition, be ground into coarse powder, sieve, mixing；

(2) take coarse powder 100g, add 5L water, decoct 20min, filter, pour in foot-bathing bucket, enter when water temperature is down to 37 DEG C-42 DEG C Row foot bath, every day 1 time, every time no less than 15 minutes.

The foot bath Tibetan medicinal composition the most according to claim 3 application in the Pediluvium medicament of preparation treatment arthromyodynia, its Being characterised by, described application process is as follows:

(1) take fully 12 taste medicines of bath Tibetan medicinal composition, be ground into 100 mesh fine powders, sieve, mixing；

(2) segmentation is poured into foot-bathing bucket adds 5L boiled water soak, when water temperature is down to 37 DEG C-42 DEG C, carry out foot bath, every day 1 time, Every time no less than 15 minutes.