CN106309551A - Perilla seed compound preparation and preparation method thereof - Google Patents
Perilla seed compound preparation and preparation method thereof Download PDFInfo
- Publication number
- CN106309551A CN106309551A CN201510383958.8A CN201510383958A CN106309551A CN 106309551 A CN106309551 A CN 106309551A CN 201510383958 A CN201510383958 A CN 201510383958A CN 106309551 A CN106309551 A CN 106309551A
- Authority
- CN
- China
- Prior art keywords
- preparation
- carnitine
- parts
- folium perillae
- compound preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 46
- 150000001875 compounds Chemical class 0.000 title claims abstract description 21
- 235000004347 Perilla Nutrition 0.000 title abstract description 11
- 241000229722 Perilla <angiosperm> Species 0.000 title abstract 10
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims abstract description 48
- 239000008187 granular material Substances 0.000 claims abstract description 17
- 238000002156 mixing Methods 0.000 claims abstract description 9
- 238000001035 drying Methods 0.000 claims abstract description 7
- 238000004806 packaging method and process Methods 0.000 claims abstract description 4
- 238000007873 sieving Methods 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 17
- 239000011230 binding agent Substances 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 239000007779 soft material Substances 0.000 claims description 9
- 229930006000 Sucrose Natural products 0.000 claims description 6
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- XINCECQTMHSORG-UHFFFAOYSA-N Isoamyl isovalerate Chemical compound CC(C)CCOC(=O)CC(C)C XINCECQTMHSORG-UHFFFAOYSA-N 0.000 claims description 3
- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 claims description 3
- 239000005913 Maltodextrin Substances 0.000 claims description 3
- 229920002774 Maltodextrin Polymers 0.000 claims description 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 3
- 229920003081 Povidone K 30 Polymers 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 3
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 3
- 240000006365 Vitis vinifera Species 0.000 claims description 3
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 3
- 229940055416 blueberry extract Drugs 0.000 claims description 3
- 235000019216 blueberry extract Nutrition 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- 235000013365 dairy product Nutrition 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 3
- 229930182830 galactose Natural products 0.000 claims description 3
- 229940035034 maltodextrin Drugs 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 16
- 210000004369 blood Anatomy 0.000 abstract description 9
- 239000008280 blood Substances 0.000 abstract description 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 8
- 208000008589 Obesity Diseases 0.000 abstract description 7
- 235000016709 nutrition Nutrition 0.000 abstract description 7
- 208000002720 Malnutrition Diseases 0.000 abstract description 6
- 208000007502 anemia Diseases 0.000 abstract description 6
- 230000001071 malnutrition Effects 0.000 abstract description 6
- 235000000824 malnutrition Nutrition 0.000 abstract description 6
- 208000015380 nutritional deficiency disease Diseases 0.000 abstract description 6
- 208000024891 symptom Diseases 0.000 abstract description 6
- 235000013305 food Nutrition 0.000 abstract description 5
- 239000000463 material Substances 0.000 abstract description 5
- 230000035764 nutrition Effects 0.000 abstract description 5
- 230000036772 blood pressure Effects 0.000 abstract description 4
- 235000012000 cholesterol Nutrition 0.000 abstract description 4
- 150000002632 lipids Chemical class 0.000 abstract description 4
- 230000035790 physiological processes and functions Effects 0.000 abstract description 4
- 235000020824 obesity Nutrition 0.000 abstract description 3
- 230000036039 immunity Effects 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 239000000853 adhesive Substances 0.000 abstract 2
- 230000001070 adhesive effect Effects 0.000 abstract 2
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 238000007781 pre-processing Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 235000019197 fats Nutrition 0.000 description 11
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 206010016256 fatigue Diseases 0.000 description 7
- 230000033001 locomotion Effects 0.000 description 7
- 230000036541 health Effects 0.000 description 6
- 238000011160 research Methods 0.000 description 6
- 206010033307 Overweight Diseases 0.000 description 5
- 229910021529 ammonia Inorganic materials 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 230000004060 metabolic process Effects 0.000 description 5
- 238000003786 synthesis reaction Methods 0.000 description 5
- 230000004580 weight loss Effects 0.000 description 5
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 206010020772 Hypertension Diseases 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 229960004488 linolenic acid Drugs 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 description 2
- 235000019750 Crude protein Nutrition 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 229960004203 carnitine Drugs 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000037323 metabolic rate Effects 0.000 description 2
- 210000001700 mitochondrial membrane Anatomy 0.000 description 2
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 235000020995 raw meat Nutrition 0.000 description 2
- 230000000391 smoking effect Effects 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 125000000185 sucrose group Chemical group 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- JXXCENBLGFBQJM-UHFFFAOYSA-N (3-carboxy-2-hydroxypropyl)-trimethylazanium;chloride Chemical compound [Cl-].C[N+](C)(C)CC(O)CC(O)=O JXXCENBLGFBQJM-UHFFFAOYSA-N 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- -1 L-carnitine compound Chemical class 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 210000000579 abdominal fat Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001430 anti-depressive effect Effects 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 150000005693 branched-chain amino acids Chemical class 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000008131 children development Effects 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013350 formula milk Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 235000020825 overweight Nutrition 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 230000007103 stamina Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a perilla seed compound preparation and a preparation method thereof. The preparation consists of the following components in parts by weight: 0.002-10 parts of perilla seeds, 0.002-3 parts of L-carnitine, 1-50 parts of an adhesive, 0.002-40 parts of a flavoring agent and 1-50 parts of a sweetening agent. The preparation method comprises the following steps: 1) sieving and pre-processing various raw materials and auxiliary materials; 2) mixing main materials in a wet-mixing granulator, uniformly mixing the materials, then adding such auxiliary materials as the adhesive and the like, and preparing granules; 4) drying the prepared granules; and 5) conducting post-treatment and packaging. According to the perilla seed compound preparation and the preparation method thereof disclosed by the invention, the perilla seeds and the L-carnitine can combined, and the compound preparation can be eaten as food; on the basis of a synergistic effect between the perilla seeds and the L-carnitine, the curative effect of the perilla seed and L-carnitine preparation, in the aspect of slimming and reducing weight, can be enhanced; in addition, the perilla seed is effective on reducing blood lipid, blood pressure, cholesterol and the like of patients with obesity; the perilla seed, with high nutrition, can avoid such symptoms as malnutrition, anemia and the like in a weight reducing process of people; and the perilla seed has such physiological functions as resisting fatigue, regulating blood lipid, boosting body immunity and the like.
Description
Technical field
The invention belongs to medicine, field of health care products, be specifically related to a kind of Folium Perillae compound preparation and preparation method thereof.
Background technology
The whole world has the people of nearly 1/3rd overweight or fat.In China, fat in explosive growth.There are about 43.6% at present, the Chinese of i.e. 600,000,000 are overweight or fat, and obesity has become global a great problem.Obesity brings a lot of undesirable conditions to people's health, and overweight people needs more oxygen because body weight increases, but lung can not increase function therewith, and overweight people's abdominal fat accumulation again limit the respiratory movement of lung simultaneously.Hypertension mostly occurs with obese patient.Hypertension may result in the organs such as brain apoplexy, kidney degeneration and heart has damage in various degree, so patient's fat-reducing of overweight and hypertension is more necessary.Heart disease, diabetes etc. are all mainly in obese people.
Folium Perillae is also known as weak, belong to Labiatae, annual herb self-pollinated plant, has special fragrance, it it is the traditional medicine edible oil materials crop of China, be first regulation of Ministry of Public Health be medicine and one of the 60 of food kinds of crops, have important Development volue in medicine food field, in recent years by extensive concern both domestic and external.
Folium Perillae originates in east Asia, has wild type and cultivation type, is distributed widely in the ground such as each provinces and regions of China, and Bhutan, India's South East Asia Mainland, Indonesia Java, Japan, Korea, at China's cultivation history of existing more than 2000 year.The north based on fuel feeding with, double as medicinal, have northwest, traditional oils producing region, 2, northeast；South is main based on medicinal, doubles as spice and eats.Folium Perillae has the effects such as sending down the abnormal ascending QI eliminating phlegm to relieve asthma intestine moistening, belongs to first and is determined one of " integration of edible and medicinal herbs " kind by ministry of Health of China.In Folium Perillae, crude protein content is up to 28%, the content of crude protein in common vegetable, and crude fiber content is up to 23.7%, containing abundant aminoacid in Folium Perillae, amino acid classes reaches 18 kinds, containing necessary to human body 8 kinds of aminoacid, has the highest nutritive value.It addition, possibly together with various bioactivators such as Folium Perillae volatile oil, alpha linolenic acid Perilla color in Folium Perillae.Modern medicine study shows: Folium Perillae have regulate the flow of vital energy and seek, antiallergic, antioxidation, antitumor, blood fat reducing, the effect such as antibacterial, AIDS virus resisting, heat-clearing and toxic substances removing, antidepressant, antiinflammatory, brain-strengthening, can be applicable to the fields such as health product medicine spice and preservative, there is important economic development value.
Containing the linolenic acid of a large amount in Folium Perillae, linolenic acid is different from any other medicines in terms of reducing adiposis patient body weight.It is mainly realized by following two approach: one is to increase metabolic rate；Two is the synthesis of suppression triglyceride, increases the excretion of internal various lipid.But fat-reducing effect to be reached, dose to increase relatively.
The research of L-carnitine starts from early in the twentieth century.1905, Russian Gulewitsch and Krimberg was found that VBT from meat extract, and henceforth, various countries scientist conducts in-depth research.
Research in early days finds, VBT is a kind of biostearin nutrient, and by its named vitamin B t.And it is true that the chemical constitution of alkali is similar to choline, close with aminoacid；Further, since some animals can be met the needs of carnitine by self synthesis, it is taken as that carnitine is not vitamin, but the most still it is referred to as DL-carnitine chloride.
The CFN of American Academy of Sciences has extensively examined the research about L-carnitine, concluded in 1989 " L-carnitine is not a kind of necessary nutritional labeling ", also avoids the need for " recommended intake ".Within 1985, in the international nutrition academic conference that Chicago is held, L-carnitine is appointed as " multifunctional and nutritional product ".
Stamina intensifying, improves sports achievement
L-carnitine is owing to can promote that fatty acid passes mitochondrial membrane and carries out aoxidizing energy supply, therefore can promote that the burning of body body fat is to provide energy when motion, L-carnitine can also promote that the oxidation of branched-chain amino acid utilizes simultaneously, the activity of mitochondrion internal respiration enzyme can be changed, such that it is able to improve the ability of body aerobic oxidation energy supply.
Therefore athlete suitably takes the energy generation that L-carnitine can improve in motion, improves the endurance level of body, thus improves sports achievement, is particularly suitable for endurance exercise project.
As far back as nineteen eighty-two, participating in the Italian of Spain's World Cup and be just widely used L-carnitine as nutritional supplement, and in this race, the physical ability of Italian sportsman is very abundant, perfect technology plays in addition, and Italian has finally won champion.Hereafter L-carnitine starts to be widely used in sporting world.
Promote fatigue recovery
Supplementary L-carnitine can promote the activity of intracellular pyruvic dehydrogenase, thus promotes that the oxidation of glucose utilizes, beneficially tired generation during delayed motion.During motion, lactic acid produces the acidity that too much can increase blood and tissue fluid, reduces the generation of ATP, causes tired generation, and supplementary L-carnitine can remove too much lactic acid, improves motor capacity, promotes the recovery of sports fatigue.Ammonia is the product of protein degradation, is also the recognition marks of sports fatigue, even if relatively low ammonia content also has bigger toxicity.Research finds that L-carnitine has the protective effect of anti-ammonia toxicity, it is possible to promotes ornithine cycle, makes ammonia be degraded to carbamide, thus release the toxicity of ammonia.
Suitably supplement L-carnitine and chronic fatigue syndrome is also had to obvious effect.L-carnitine participates in many metabolism links, and it is improving the immunity of human body, the stability of protection cell membrane, and raising exercise tolerance, resisting fatigue face play an important role.The shortage actively correcting L-carnitine can promote the recovery of the various metabolism disorder of chronic fatigue syndrome patient, the energy synthesis of enhancing body, improves largest motion endurance level, plays antifatigue effect.Preventing and treating for subhealth state can also play a role.
Delaying senility course
Energy is maximum defying age strength, and cell has enough energy will be dynamic.In human aging process, weakening of cellular energy is that it accelerates one of old and feeble reason, and suitably supplementing L-carnitine can be with the process of slow down aging.
It addition, enough energy play a part a protection for cell, during body aging, cellular energy is under-supply, and supplementary L-carnitine is not only able to provide enough energy, and can keep immune strong, thus avoids the invasion and attack of some diseases.
Be conducive to infantile health
L-carnitine belongs to the required nutrient substance of conditionality baby, plays an important role in baby utilizes fat as the metabolism of energy source.
Baby's L-carnitine synthesis capability is more weak, 12% be only grown up, especially premature infant, it is necessary to supplemented with exogenous L-carnitine, needed for could meeting health.
L-carnitine not only produces at energy and plays an important role in fat metabolic process, and is maintaining baby's life and promoting some physiological process of infant development, is respectively provided with certain function in terms of the ketogenesis, nitrogen metabolism etc..At present, existing 22 countries of the world add L-carnitine in baby milk powder, and China has added the humanized milk powder listing of L-carnitine.
Summary of the invention
The technical issues that need to address of the present invention are to provide a kind of Folium Perillae compound preparation and preparation method thereof, said preparation is based on weight-reducing, have the effects such as the reduction blood fat and blood pressure of adiposis patient, cholesterol concurrently, the high nutrition of Folium Perillae can avoid the symptoms such as malnutrition and the anemia of people in weight loss procedures, can be with physiological functions such as resisting fatigue, regulation blood fat, raising human body immunocompetences.
For solving the problems referred to above, the technical solution used in the present invention is:
A kind of Folium Perillae compound preparation, it includes the composition of following weight portion: Folium Perillae 0.002～10 parts, L-carnitine 0.002～3 parts, binding agent 1～50 parts, correctives 0.002～40 parts, sweeting agent 1～50 parts.
Further, any one or more than one the compositions during described sweeting agent is sucrose, oligomeric isomaltose, reduced isomaltooligosaccharide, xylitol, sorbitol, maltose alcohol, oligomeric galactose, oligofructose.
Further, any one during described binding agent is sucrose, starch, dextrin, maltodextrin, carboxymethyl cellulose, PVP K30.
Further, any one during described correctives is probably non-dairy creamer, blueberry extract, apple essence, grape essence, Fructus Citri Limoniae essence.
The preparation method of Folium Perillae compound preparation of the present invention is as follows:
(1) pretreatment
Carry out sieving pretreatment by each supplementary material, crosses 80-100 mesh sieve respectively, then weighs corresponding weight respectively by ratio requirement standby；
(2) pelletize
Load weighted supplementary material (Folium Perillae, L-carnitine, sweeting agent) being put into wet mixing pelletizer mix, place into binding agent and carry out soft material processed, be simultaneously introduced correctives after mix homogeneously, the state of " hands is pinched agglomerating, pressure the most scattered " made by soft material；Again the soft material made being crossed oscillating granulator to pelletize, oscillating granulator joins 14-22 mesh sieve；
(3) it is dried
The granule made being put drying fluidized-bed be dried, baking temperature 60-80 DEG C, degree of drying is as the criterion within 2% with moisture Control；
(4) arrange
Dried granule carries out granulate sieve and make it uniform；
(5) always mix
Step (4) is screened uniform granule always mix 10-30 minute so that it is mixing dispersion is evenly；
(6) packaging
The granule mixed employing automatic subpackaging particles packing machine is carried out subpackage.
Use and have the beneficial effects that produced by technique scheme: Folium Perillae and L-carnitine are carried out compounded combination by the present invention, can eat as food, oleum lini and L-carnitine in Folium Perillae are all to be lost weight by increase metabolism, utilize the synergism of Folium Perillae and L-carnitine, improve Folium Perillae L-carnitine preparation curative effect in terms of slimming, additionally Folium Perillae can reduce the blood fat and blood pressure of adiposis patient, cholesterol etc., the high nutrition of Folium Perillae can avoid the symptoms such as malnutrition and the anemia of people in weight loss procedures, can be with resisting fatigue, regulation blood fat, improve the physiological functions such as human body immunocompetence.
Detailed description of the invention
Below the present invention is described in further detail: should be understood that; below it is only some preferred embodiments of the present invention; protection scope of the present invention is not limited to that, every the most creative improvement made under spiritual principles of the present invention, all within protection scope of the present invention.
The invention provides a kind of Folium Perillae compound preparation for weight-reducing and preparation method thereof.This Folium Perillae compound preparation includes the ingredient of following weight portion: Folium Perillae 0.002～10 parts, L-carnitine 0.002～3 parts, binding agent 1～50 parts, correctives 0.002～40 parts, sweeting agent 1～50 parts.
Described sweeting agent is any one or more than one the compositions in sucrose, oligomeric isomaltose, reduced isomaltooligosaccharide, xylitol, sorbitol, maltose alcohol, oligomeric galactose, oligofructose.
Described binding agent is any one in sucrose, starch, dextrin, maltodextrin, carboxymethyl cellulose, PVP K30.
Described correctives is probably any one in non-dairy creamer, blueberry extract, apple essence, grape essence, Fructus Citri Limoniae essence.
The mechanism of action of each composition in the present invention:
Folium Perillae: increase metabolic rate, the synthesis of suppression triglyceride, increases the excretion of internal various lipid, reduces the blood fat and blood pressure of adiposis patient, cholesterol etc., the high nutrition of Folium Perillae can avoid the symptoms such as malnutrition and the anemia of people in weight loss procedures, it is also possible to resisting fatigue.
L-carnitine: promote that fatty acid carries out aoxidizing energy supply through mitochondrial membrane, is a kind of delivery enzyme.
Correctives, sweeting agent: in order to improve taste and the mouthfeel of preparation, make people be prone to accept.
Binding agent: as binding agent in pelletization, and the content of monomer of preparation is improved as filler.
The preparation technology of this Folium Perillae compound preparation is as follows:
((1) pretreatment
Carry out sieving pretreatment by each supplementary material, crosses 80-100 mesh sieve respectively, then weighs corresponding weight respectively by ratio requirement standby；
(2) pelletize
Load weighted supplementary material (Folium Perillae, L-carnitine, sweeting agent) being put into wet mixing pelletizer mix, place into binding agent and carry out soft material processed, be simultaneously introduced correctives after mix homogeneously, the state of " hands is pinched agglomerating, pressure the most scattered " made by soft material；Again the soft material made being crossed oscillating granulator to pelletize, oscillating granulator joins 14-22 mesh sieve；
(3) it is dried
The granule made being put drying fluidized-bed be dried, baking temperature 60-80 DEG C, degree of drying is as the criterion within 2% with moisture Control；
(4) arrange
Dried granule carries out granulate sieve and make it uniform；
(5) always mix
Step (4) is screened uniform granule always mix 10-30 minute so that it is mixing dispersion is evenly；
(6) packaging
The granule mixed employing automatic subpackaging particles packing machine is carried out subpackage.
Embodiment 1 ~ 5
Following table is the component data of Folium Perillae compound preparation embodiment 1 ~ 5 of the present invention:
The effect experimental of technical solution of the present invention
In order to verify after Folium Perillae of the present invention and L-carnitine compounded combination the different-effect with common L-carnitine preparation, inventor is prepared as Folium Perillae compound preparation according to the component proportion of embodiment 1～5, it is respectively designated as experimental example 1～5, the body weight of 180 20～40 years old are carried out clinical trial at 130-150 jin relatively Obese Women, above-mentioned testing crew is divided into 6 groups, take experimental example 1～5 and common L-carnitine preparation respectively, experimental subject to experimental example 1～5 daily contains the preparation of L-carnitine 22.5mg, take 30 days, coordinate 20 minutes jog every day, period avoids smoking, drink, food raw meat is peppery；Take common L-carnitine preparation person daily containing the preparation of L-carnitine 22.5mg, take 30 days, coordinate every day 20 minutes jog, period avoid smoking, drink, to eat raw meat peppery, carries out the Folium Perillae L-carnitine compound preparation of the present invention clinical research to slimming.The following is data table 2.
Table 2: clinical test results
Somatic reaction situation in weight loss procedures, ordinary preparation group has malnutrition, in motion asthma feel bad, the symptom such as anemia, embodiment 1-5 group only has above situation for first 3 days clinical, above situation does not the most occur.
By testing above it can be seen that take Folium Perillae compound preparation person substantially ratio to take simple L-carnitine preparation person, weight-reducing effect to be got well, and avoids the symptoms such as the malnutrition in weight loss procedures, anemia.Take the effect of experimental example 4 in Folium Perillae compound preparation person best, experimental example 1 effect is worst, according to drug mechanism, binding tests aggregation of data is analyzed, and Folium Perillae is how many at the content of recipe ingredient, it is directly connected to the effect of weight-reducing, reasonably proportioning, allows Folium Perillae and L-carnitine synergism, the respective curative effect of competence exertion, therefore, the optimum proportioning of the present invention is the proportioning of experimental example 4.
Claims (5)
1. a Folium Perillae compound preparation, it is characterised in that: it includes the composition of following weight portion: Folium Perillae 0.002～10 parts, L-carnitine 0.002～3 parts, binding agent 1～50 parts, correctives 0.002～40 parts, sweeting agent 1～50 parts.
Folium Perillae compound preparation the most according to claim 1, it is characterised in that described sweeting agent is any one or more than one the compositions in sucrose, oligomeric isomaltose, reduced isomaltooligosaccharide, xylitol, sorbitol, maltose alcohol, oligomeric galactose, oligofructose.
Folium Perillae compound preparation the most according to claim 1, it is characterised in that described binding agent is any one in sucrose, starch, dextrin, maltodextrin, carboxymethyl cellulose, PVP K30.
Folium Perillae compound preparation the most according to claim 1, it is characterised in that described correctives is probably any one in non-dairy creamer, blueberry extract, apple essence, grape essence, Fructus Citri Limoniae essence.
The preparation method of Folium Perillae compound preparation the most according to claim 1 is as follows:
(1) pretreatment
Carry out sieving pretreatment by each supplementary material, crosses 80-100 mesh sieve respectively, then weighs corresponding weight respectively by ratio requirement standby；
(2) pelletize
By load weighted supplementary material---Folium Perillae, L-carnitine, sweeting agent are put into wet mixing pelletizer and are mixed, and place into binding agent and carry out soft material processed, be simultaneously introduced correctives after mix homogeneously, and the state of " hands is pinched agglomerating, pressure the most scattered " made by soft material；Again the soft material made being crossed oscillating granulator to pelletize, oscillating granulator joins 14-22 mesh sieve；
(3) it is dried
The granule made being put drying fluidized-bed be dried, baking temperature 60-80 DEG C, degree of drying is as the criterion within 2% with moisture Control；
(4) arrange
Dried granule carries out granulate sieve and make it uniform；
(5) always mix
Step (4) is screened uniform granule always mix 10-30 minute so that it is mixing dispersion is evenly；
(6) packaging
The granule mixed employing automatic subpackaging particles packing machine is carried out subpackage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510383958.8A CN106309551A (en) | 2015-07-03 | 2015-07-03 | Perilla seed compound preparation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510383958.8A CN106309551A (en) | 2015-07-03 | 2015-07-03 | Perilla seed compound preparation and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106309551A true CN106309551A (en) | 2017-01-11 |
Family
ID=57727849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510383958.8A Pending CN106309551A (en) | 2015-07-03 | 2015-07-03 | Perilla seed compound preparation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106309551A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106890307A (en) * | 2017-03-21 | 2017-06-27 | 中国中医科学院中医基础理论研究所 | A kind of Chinese medicine composition with effect for reducing blood fat |
| CN111110758A (en) * | 2018-10-31 | 2020-05-08 | 西南民族大学 | A kind of ointment and use thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002096219A2 (en) * | 2001-05-31 | 2002-12-05 | Abbott Laboratories | Acid controlled viscosity fiber system and uses thereof |
| CN101253903A (en) * | 2008-04-07 | 2008-09-03 | 北京惠中铭捷生物科技有限公司 | Health food and its preparation with fat-reducing function |
| CN101422544A (en) * | 2007-10-29 | 2009-05-06 | 王�琦 | Haifei capsule formulation with weight reduction function and preparation method thereof |
-
2015
- 2015-07-03 CN CN201510383958.8A patent/CN106309551A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002096219A2 (en) * | 2001-05-31 | 2002-12-05 | Abbott Laboratories | Acid controlled viscosity fiber system and uses thereof |
| CN101422544A (en) * | 2007-10-29 | 2009-05-06 | 王�琦 | Haifei capsule formulation with weight reduction function and preparation method thereof |
| CN101253903A (en) * | 2008-04-07 | 2008-09-03 | 北京惠中铭捷生物科技有限公司 | Health food and its preparation with fat-reducing function |
Non-Patent Citations (2)
| Title |
|---|
| 尹承昊: "《体能增长与健身训练》", 31 March 2014, 山东科学技术出版社 * |
| 赵余庆 等: "《食疗与保健食品原料功能因子手册》", 31 March 2013, 中国医药科技出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106890307A (en) * | 2017-03-21 | 2017-06-27 | 中国中医科学院中医基础理论研究所 | A kind of Chinese medicine composition with effect for reducing blood fat |
| CN106890307B (en) * | 2017-03-21 | 2018-07-10 | 中国中医科学院中医基础理论研究所 | A kind of Chinese medicine composition with effect for reducing blood fat |
| CN111110758A (en) * | 2018-10-31 | 2020-05-08 | 西南民族大学 | A kind of ointment and use thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103918965B (en) | A kind of beverage of alleviating physical fatigue | |
| CN102524872B (en) | Ginseng peptide amino acid drink | |
| CN106858620A (en) | A kind of anaemia tailored version clinical nutrition formula and preparation method thereof | |
| CN103110861B (en) | Granular preparation for preventing infants from getting inflamed and adjusting intestines and stomach and preparation method thereof | |
| CN108651998A (en) | It is a kind of have relieve fatigue PURE WHEY of function and preparation method thereof | |
| CN102512655B (en) | L-carnitine composition, L-carnitine preparation and preparation method and application thereof | |
| CN102919450B (en) | Cereal leaching solution herbal tea and method for preparing same | |
| CN105341947B (en) | Nutrient powder bags capable of improving sleep | |
| CN105166923A (en) | Health-care corn peptide food and making method | |
| CN102090563B (en) | Health food for stress relief and sleep relief and preparation method thereof | |
| CN106912960A (en) | A kind of hypoglycemia healthcare food and preparation method thereof | |
| CN106615431A (en) | Sliced helianthus tuberosus tea and making method thereof | |
| CN102326815A (en) | Worm grass oral liquid and preparation method thereof | |
| CN108606269B (en) | Sports nutritional supplement and preparation method thereof | |
| CN102657304B (en) | Health-care food with double functions of promoting digestion and relieving physical fatigue | |
| CN104431755A (en) | Preparation method of buckwheat health-care product | |
| CN106309551A (en) | Perilla seed compound preparation and preparation method thereof | |
| CN103005435B (en) | Anti-fatigue composition capable of improving speed endurance and preparation containing anti-fatigue composition | |
| CN107981055A (en) | The adult feed for sheep prepared using crop material | |
| CN102090637A (en) | Collagen-containing compound nutritious powder | |
| CN105265960A (en) | Fruit and vegetable drink special for patient suffering from diabetes | |
| CN101214052B (en) | Health food with physical energy fatigue alleviating and immunity reinforcing function | |
| CN104382002A (en) | Maca tablet for alleviating fatigue | |
| CN103110114B (en) | Beta-alanine-containing composition for endurance increase, and preparation thereof | |
| CN104839846A (en) | Ginseng functional health sports drink and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170111 |