CN106275733B - A kind of vial and preparation method thereof for that can reduce to the loss of expensive powdered samples - Google Patents
A kind of vial and preparation method thereof for that can reduce to the loss of expensive powdered samples Download PDFInfo
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- CN106275733B CN106275733B CN201610792457.XA CN201610792457A CN106275733B CN 106275733 B CN106275733 B CN 106275733B CN 201610792457 A CN201610792457 A CN 201610792457A CN 106275733 B CN106275733 B CN 106275733B
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- vial
- ptfe
- methanol solution
- drying
- spraying
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D23/00—Details of bottles or jars not otherwise provided for
- B65D23/02—Linings or internal coatings
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Surface Treatment Of Glass (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Abstract
本发明公开了一种用于可减小对昂贵粉末状样品损耗的玻璃瓶及其制作方法。一种用于可减小对昂贵粉末状样品损耗的玻璃瓶，将玻璃样品瓶内部涂覆上一层聚四氟乙烯。所述的涂覆PTFE的玻璃瓶的制备方法包括以下步骤：步骤a打磨；步骤b清洗；步骤c烘干；步骤d硅烷化；步骤e喷涂；步骤f固化。发明的积极效果是(1)本发明所制备的内壁涂覆了PTFE材料的玻璃瓶价格低廉，内壁表面能小，有效降低了粉末状样品在瓶壁上的粘附，极大的提高了样品的利用效率。(2)本发明加工过程简单，可用于大规模生产。充分发挥了玻璃瓶价格低廉，PTFE材料易于涂覆的特点。
The invention discloses a glass bottle which can reduce the loss of expensive powder samples and a manufacturing method thereof. A glass vial for reducing the loss of expensive powdered samples, the inside of the glass vial is coated with a layer of Teflon. The preparation method of the PTFE-coated glass bottle includes the following steps: step a polishing; step b cleaning; step c drying; step d silanization; step e spraying; step f curing. The positive effect of the invention is (1) the glass bottle with the inner wall coated with PTFE material prepared by the present invention is cheap, and the surface energy of the inner wall is small, which effectively reduces the adhesion of the powdery sample on the bottle wall, and greatly improves the sample. utilization efficiency. (2) The process of the present invention is simple and can be used for large-scale production. It takes full advantage of the low price of glass bottles and the easy coating of PTFE materials.
Description
Technical field
The present invention relates to a kind of vials and preparation method thereof for that can reduce to the loss of expensive powdered samples, belong to
Sample preservation field.
Background technique
Vial has chemical inertness simultaneously since it is cheap, is always the storage container of powdered chemical drug, and with
Sample partial size it is smaller, surface can be also bigger, the powder that causes many partial sizes superfine also bigger with the surface tension of glass
Shape sample is stored in glass container, is had and is largely adhered to glass surface, and the sample of usually these adherency can only be dropped, and is made
At unnecessary loss.For common sample, these losses may can be born, but for sample costly, such as albumen
Sample, biological active matter quality sample, usual gram of valence all in tens of thousands of members, is divided in the micro-example bottle of 100mg, and is adhered to glass
Sample size on glass surface will be more than 10%, that is, the loss of several hundred to thousands of members, this loss make people very distressed.
Polytetrafluoroethylene (PTFE) (PTFE) is the high-molecular compound as made of tetrafluoroethylene polymerization, is commonly called as " Teflon ", corrosion resistant
Erosion, is a kind of chemically inert polymer material, this material has the advantages that surface can be especially small simultaneously, so wide
It is general to be used for non-stick pan, coating material, pipe fitting, the container of military articles etc..Also there are a large amount of polytetrafluoroethylcontainer containers currently on the market,
But usually all costly, g grades of volumetric flask will be 100 yuan or so.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the existing defects, provides a kind of for that can reduce to expensive powder
The vial and preparation method thereof of shape sample loss.The resulting vial for being coated with PTFE of this method can greatly reduce glass
The surface energy of glass bottle inner surface, reduces adherency of the powdered samples on vial, effectively improves making for expensive powdered samples
Use efficiency.
In order to solve the above-mentioned technical problems, the present invention provides the following technical solutions:
A kind of vial for that can reduce to the loss of expensive powdered samples, by one layer in glass sample bottle internal coat
Polytetrafluoroethylene (PTFE) (PTFE), PTFE coating, which can play, reduces glass surface energy, reduces the work of attachment of the sample powder on glass
With.
Be preferably in the above scheme, the preparation method of the vial of the coated with PTFE the following steps are included:
Step a. polishing: polishing to vial inner surface with sandblasting, increases the degree of roughness of vial inner surface；
Step b. cleaning: the organic impurities of vial inner surface is cleaned with alcohol reagent, is then washed with water in vial
The impurity and alcohol reagent on surface；
Step c. drying: vial is put into the inner surface of drying box drying vial；
Step d. silanization: mass fraction is molten for 3-aminopropyltriethoxysilane (AMEO) methanol of 6%-10%
Liquid is added in vial, and it is molten to pour out 3-aminopropyltriethoxysilane methanol (AMEO) methanol after stirring or oscillation 10 seconds or more
Liquid washes away excessive 3-aminopropyltriethoxysilane methanol (AMEO) methanol solution with methanol, after natural drying by vial
It is heated 1 hour in 100 DEG C, completes the silanization to vial inner surface；
Step e. spraying: injecting flush coater for the methanol solution for the polytetrafluoroethylene (PTFE) (PTFE) that mass fraction is 4%-6%,
To vial inner surface even application, the vial after spraying is put into drying box and is spontaneously dried, organic solvent is vapored away；
Step f. solidifies: the vial after spraying being put into 80 DEG C of -100 DEG C of baking ovens, stands 10-15 minutes, completes poly- four
The solidification of vinyl fluoride (PTFE) coating.
In any of the above-described scheme preferably, the vial is 5mL brown mother glass bottle.
In any of the above-described scheme preferably, polytetrafluoroethylene (PTFE) (PTFE) solution in the step e is poly- for nanoscale
Tetrafluoroethene (PTFE) solution, nano particle diameter is less than 100 nanometers.
In any of the above-described scheme preferably, cleaning operation uses supersonic wave cleaning machine in the step b.
The present invention also provides above-mentioned for that can reduce the production method of the vial to the loss of expensive powdered samples, special
Sign is: the following steps are included:
Step a. polishing: polishing to vial inner surface with sandblasting, increases the degree of roughness of vial inner surface；
Step b. cleaning: the organic impurities of vial inner surface is cleaned with alcohol reagent, is then washed with water in vial
The impurity and alcohol reagent on surface；
Step c. drying: vial is put into the inner surface of drying box drying vial；
Step d. silanization: mass fraction is molten for 3-aminopropyltriethoxysilane (AMEO) methanol of 6%-10%
Liquid is added in vial, and it is molten to pour out 3-aminopropyltriethoxysilane methanol (AMEO) methanol after stirring or oscillation 10 seconds or more
Liquid washes away excessive 3-aminopropyltriethoxysilane methanol (AMEO) methanol solution with methanol, after natural drying by vial
It is heated 1 hour in 100 DEG C, completes the silanization to vial inner surface；
Step e. spraying: injecting flush coater for the methanol solution for the polytetrafluoroethylene (PTFE) (PTFE) that mass fraction is 4%-6%,
To vial inner surface even application, the vial after spraying is put into drying box and is spontaneously dried, organic solvent is vapored away；
Step f. solidifies: the vial after spraying being put into 80 DEG C of -100 DEG C of baking ovens, stands 10-15 minutes, completes poly- four
The solidification of vinyl fluoride (PTFE) coating.
It is preferably in the above scheme, the vial is 5mL brown mother glass bottle.
In any of the above-described scheme preferably, polytetrafluoroethylene (PTFE) (PTFE) solution in the step e is poly- for nanoscale
Tetrafluoroethene PTFE solution, nano particle diameter is less than 100 nanometers.
In any of the above-described scheme preferably, cleaning operation uses supersonic wave cleaning machine in the step b.
Compared with prior art, the positive effect of the present invention is:
(1) present invention prepared by inner wall be coated with PTFE material vial it is cheap, inner wall surface can it is small, effectively
Adherency of the powdered samples in bottle wall is reduced, the utilization efficiency of sample is greatly improved
(2) process of the present invention is simple, can be used for being mass produced.It is cheap vial is given full play to, PTFE
Material is easy to the characteristics of coating.
Detailed description of the invention
Fig. 1: three kinds of samples remaining sample amount average value in two kinds of vials compares in embodiment 4.
Specific embodiment
Hereinafter, preferred embodiments of the present invention will be described, it should be understood that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.
Embodiment 1
A kind of vial for that can reduce to the loss of expensive powdered samples, comprising the following steps:
(1) it polishes: being polished with sandblasting vial inner surface, increase the degree of roughness of vial inner surface；
(2) it cleans: cleaning the organic impurities of vial inner surface with alcohol reagent, then wash with water vial inner surface
Impurity and alcohol reagent；
(3) it dries: vial is put into the inner surface of drying box drying vial；
(4) silanization: 6% 3-aminopropyltriethoxysilane (AMEO) methanol solution is added in vial, is stirred
It mixes or pours out AMEO solution after vibrating 10 seconds or more, excessive AMEO solution is washed away with methanol, by vial after natural drying in 100
It DEG C heating 1 hour, completes to the silanization of vial inner surface；
(5) it sprays: the methanol solution injection flush coater of 4% PTFE will spray vial inner surface even application
Vial afterwards, which is put into drying box, to be spontaneously dried, and organic solvent is vapored away；
(6) solidify: the vial after spraying being put into 100 DEG C of baking ovens, stands 10 minutes, completes the solidification of PTFE coating.
Embodiment 2
A kind of vial for that can reduce to the loss of expensive powdered samples, comprising the following steps:
(1) it polishes: being polished with sandblasting vial inner surface, increase the degree of roughness of vial inner surface；
(2) it cleans: cleaning the organic impurities of vial inner surface with alcohol reagent, then wash with water vial inner surface
Impurity and alcohol reagent；
(3) it dries: vial is put into the inner surface of drying box drying vial；
(4) silanization: 10% 3-aminopropyltriethoxysilane (AMEO) methanol solution is added in vial, is stirred
It mixes or pours out AMEO solution after vibrating 10 seconds or more, excessive AMEO solution is washed away with methanol, by vial after natural drying in 100
It DEG C heating 1 hour, completes to the silanization of vial inner surface；
(5) it sprays: the methanol solution injection flush coater of 6% PTFE will spray vial inner surface even application
Vial afterwards, which is put into drying box, to be spontaneously dried, and organic solvent is vapored away；
(6) solidify: the vial after spraying being put into 80 DEG C of baking ovens, stands 15 minutes, completes the solidification of PTFE coating.
Embodiment 3
A kind of vial for that can reduce to the loss of expensive powdered samples, comprising the following steps:
(1) it polishes: being polished with sandblasting vial inner surface, increase the degree of roughness of vial inner surface；
(2) it cleans: cleaning the organic impurities of vial inner surface with alcohol reagent, then wash with water vial inner surface
Impurity and alcohol reagent；
(3) it dries: vial is put into the inner surface of drying box drying vial；
(4) silanization: 8% 3-aminopropyltriethoxysilane (AMEO) methanol solution is added in vial, is stirred
It mixes or pours out AMEO solution after vibrating 10 seconds or more, excessive AMEO solution is washed away with methanol, by vial after natural drying in 100
It DEG C heating 1 hour, completes to the silanization of vial inner surface；
(5) it sprays: the methanol solution injection flush coater of 5% PTFE will spray vial inner surface even application
Vial afterwards, which is put into drying box, to be spontaneously dried, and organic solvent is vapored away；
(6) solidify: the vial after spraying being put into 90 DEG C of baking ovens, stands 12 minutes, completes the solidification of PTFE coating.
Embodiment 4
With bovine serum albumin(BSA) (BSA), cromoci (Cytochrome C), polyethylene glycol 200 k (PEO 200k) three
Kind substance is sample, takes the inner surface prepared in 10 2mL simple glass bottles and 10 2mL embodiments 1 coating PTFE material
Vial, tri- kinds of powder samples of accurate weighing 100mg are separately added into each vial respectively in batches.These samples are distinguished
Pour out, weigh the sample size m that each vial is poured out respectively, calculate remaining sample amount 100-m in vial, three kinds of samples it is surplus
Remaining sample size is as shown in table 1.The average value of the remaining sample amount of simple glass bottle and PTFE inner wall vial is calculated, and does figure such as
Shown in Fig. 1.Remaining sample amount will be far fewer than remaining in simple glass bottle in vial as can be seen from Figure through PTFE modification inner wall
Remaining sample size, illustrate through PTFE modify inner wall vial can be very good reduce powdered samples glass inner wall absorption,
Have the function that reduce sample loss.
The remaining sample amount of 1 three kinds of samples of table
Finally, it should be noted that the foregoing is only a preferred embodiment of the present invention, it is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in of the invention
Within protection scope.
Claims (8)
1. a kind of vial for that can reduce to the loss of expensive powdered samples, it is characterised in that: inside glass sample bottle
Painting is covered with a strata tetrafluoroethene,
The preparation method of the vial of coated with PTFE the following steps are included:
Step a. polishing: it is polished with sandblasting vial inner surface；
Step b. cleaning: the organic impurities of vial inner surface is cleaned with alcohol reagent, then washes with water vial inner surface
Impurity and alcohol reagent；
Step c. drying: vial is put into the inner surface of drying box drying vial；
Step d. silanization: glass is added in the 3-aminopropyltriethoxysilane methanol solution that mass fraction is 6%-10%
In bottle, stirs or pour out 3-aminopropyltriethoxysilane methanol solution after oscillation 10 seconds or more, wash away excessive 3- with methanol
Vial is heated 1 hour in 100 DEG C after natural drying, is completed to vial by aminopropyltriethoxywerene werene methanol solution
The silanization of inner surface；
Step e. spraying: the methanol solution for the polytetrafluoroethylene (PTFE) that mass fraction is 4%-6% is injected into flush coater, in vial
Vial after spraying is put into drying box and spontaneously dries, vapors away organic solvent by surface even application；
Step f. solidifies: the vial after spraying being put into 80 DEG C of -100 DEG C of baking ovens, stands 10-15 minutes, completes polytetrafluoroethyl-ne
The solidification of ene coatings.
2. vial as described in claim 1, it is characterised in that: the vial is 5mL brown mother glass bottle.
3. vial as described in claim 1, it is characterised in that: the methanol solution of the polytetrafluoroethylene (PTFE) in the step e is
Nanoscale polytetrafluoroethylsolution solution, nano particle diameter is less than 100 nanometers.
4. vial as described in claim 1, it is characterised in that: cleaning operation uses supersonic wave cleaning machine in the step b.
5. as described in claim 1 for the production method of the vial to the loss of expensive powdered samples, feature can be reduced
It is: the following steps are included:
Step a. polishing: it is polished with sandblasting vial inner surface；
Step b. cleaning: the organic impurities of vial inner surface is cleaned with alcohol reagent, then washes with water vial inner surface
Impurity and alcohol reagent；
Step c. drying: vial is put into the inner surface of drying box drying vial；
Step d. silanization: glass is added in the 3-aminopropyltriethoxysilane methanol solution that mass fraction is 6%-10%
In bottle, stirs or pour out 3-aminopropyltriethoxysilane methanol solution after oscillation 10 seconds or more, wash away excessive 3- with methanol
Vial is heated 1 hour in 100 DEG C after natural drying, is completed to vial by aminopropyltriethoxywerene werene methanol solution
The silanization of inner surface；
Step e. spraying: the methanol solution for the polytetrafluoroethylene (PTFE) that mass fraction is 4%-6% is injected into flush coater, in vial
Vial after spraying is put into drying box and spontaneously dries, vapors away organic solvent by surface even application；
Step f. solidifies: the vial after spraying being put into 80 DEG C of -100 DEG C of baking ovens, stands 10-15 minutes, completes polytetrafluoroethyl-ne
The solidification of ene coatings.
6. production method as claimed in claim 5, it is characterised in that: the vial is 5mL brown mother glass bottle.
7. production method as claimed in claim 5, it is characterised in that: the methanol solution of the polytetrafluoroethylene (PTFE) in the step e
For nanoscale polytetrafluoroethylsolution solution, nano particle diameter is less than 100 nanometers.
8. production method as claimed in claim 5, it is characterised in that: cleaning operation uses ultrasonic cleaning in the step b
Machine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610792457.XA CN106275733B (en) | 2016-08-31 | 2016-08-31 | A kind of vial and preparation method thereof for that can reduce to the loss of expensive powdered samples |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610792457.XA CN106275733B (en) | 2016-08-31 | 2016-08-31 | A kind of vial and preparation method thereof for that can reduce to the loss of expensive powdered samples |
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| Publication Number | Publication Date |
|---|---|
| CN106275733A CN106275733A (en) | 2017-01-04 |
| CN106275733B true CN106275733B (en) | 2019-03-26 |
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| CN201610792457.XA Expired - Fee Related CN106275733B (en) | 2016-08-31 | 2016-08-31 | A kind of vial and preparation method thereof for that can reduce to the loss of expensive powdered samples |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018140698A1 (en) * | 2017-01-27 | 2018-08-02 | Tedia Company, Inc. | Chemical reagent bottle internally coated with a fluoropolymer |
| CN116395979B (en) * | 2023-03-08 | 2025-03-21 | 杭州师范大学 | A high-efficiency silicidation method for medium-borosilicate glass |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE758541A (en) * | 1969-11-05 | 1971-05-05 | Corning Glass Works | STRENGTHENING AND ANTI-WETTING COATINGS FOR FRAGILE ARTICLES |
| CN2378296Y (en) * | 1999-04-08 | 2000-05-17 | 康庆刚 | Container with PTEF (polytetrafluoroethylene) |
| CN202295631U (en) * | 2011-10-11 | 2012-07-04 | 桐乡市科力复合材料有限公司 | Special heating bag for microwave oven |
| CN105711865B (en) * | 2014-12-02 | 2019-03-05 | 杭州超达食品有限公司 | Loading hopper and its preserved fruit filling process with anti-sticking structure |
| FR3031740B1 (en) * | 2015-01-15 | 2017-02-24 | Sgd Sa | CONTAINER COVERED WITH PROTECTIVE AND RETENTION COATING, KIT FOR MANUFACTURING PROTECTIVE COATING AND RETENTION COATING, AND MANUFACTURING METHOD THEREOF |
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