CN106265479A - A kind of skin repair compositions and preparation method thereof - Google Patents
A kind of skin repair compositions and preparation method thereof Download PDFInfo
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- CN106265479A CN106265479A CN201610950431.3A CN201610950431A CN106265479A CN 106265479 A CN106265479 A CN 106265479A CN 201610950431 A CN201610950431 A CN 201610950431A CN 106265479 A CN106265479 A CN 106265479A
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- skin repair
- repair compositions
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- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 230000008439 repair process Effects 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000012071 phase Substances 0.000 claims abstract description 35
- 239000008346 aqueous phase Substances 0.000 claims abstract description 29
- 239000011265 semifinished product Substances 0.000 claims abstract description 18
- 239000003974 emollient agent Substances 0.000 claims abstract description 15
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 13
- 239000000080 wetting agent Substances 0.000 claims abstract description 13
- 239000002904 solvent Substances 0.000 claims abstract description 12
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 10
- 229940041514 candida albicans extract Drugs 0.000 claims abstract description 10
- 238000010438 heat treatment Methods 0.000 claims abstract description 10
- 239000012138 yeast extract Substances 0.000 claims abstract description 10
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 9
- 239000000419 plant extract Substances 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims description 14
- 239000000284 extract Substances 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 4
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 2
- 229930182478 glucoside Natural products 0.000 claims description 2
- 150000008131 glucosides Chemical class 0.000 claims description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 2
- 229960001295 tocopherol Drugs 0.000 claims description 2
- 229930003799 tocopherol Natural products 0.000 claims description 2
- 235000010384 tocopherol Nutrition 0.000 claims description 2
- 239000011732 tocopherol Substances 0.000 claims description 2
- 125000002640 tocopherol group Chemical group 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 40
- 210000002615 epidermis Anatomy 0.000 abstract description 6
- 239000003862 glucocorticoid Substances 0.000 abstract description 5
- 235000016709 nutrition Nutrition 0.000 abstract description 4
- 230000035764 nutrition Effects 0.000 abstract description 4
- 238000011084 recovery Methods 0.000 abstract description 3
- 239000003921 oil Substances 0.000 description 10
- 235000019198 oils Nutrition 0.000 description 10
- 239000000047 product Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 208000003251 Pruritus Diseases 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
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- 229960003957 dexamethasone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
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- 238000012360 testing method Methods 0.000 description 3
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
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- 239000002994 raw material Substances 0.000 description 2
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- 229940087291 tridecyl alcohol Drugs 0.000 description 2
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 description 1
- NFLGAXVYCFJBMK-DTWKUNHWSA-N (+)-menthone Chemical compound CC(C)[C@H]1CC[C@H](C)CC1=O NFLGAXVYCFJBMK-DTWKUNHWSA-N 0.000 description 1
- XFRVVPUIAFSTFO-UHFFFAOYSA-N 1-Tridecanol Chemical compound CCCCCCCCCCCCCO XFRVVPUIAFSTFO-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241000050051 Chelone glabra Species 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 description 1
- OQILCOQZDHPEAZ-UHFFFAOYSA-N Palmitinsaeure-octylester Natural products CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010040851 Skin fragility Diseases 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- 206010048222 Xerosis Diseases 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
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- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
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- 230000019522 cellular metabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 229940097572 chloromycetin Drugs 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 229940086555 cyclomethicone Drugs 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 229930007503 menthone Natural products 0.000 description 1
- WRWRKDRWMURIBI-UHFFFAOYSA-M mercuric amidochloride Chemical compound N[Hg]Cl WRWRKDRWMURIBI-UHFFFAOYSA-M 0.000 description 1
- 229960000432 mercuric amidochloride Drugs 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000022558 protein metabolic process Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of skin repair compositions, including composition: solvent；Aqueous phase wetting agent；Oil phase emollient；Emulsifying agent；Antioxidant；Yeast extract；Plant extract；The preparation method of described skin repair compositions includes step: 1) by oil phase emollient and emulsifying agent heating for dissolving, obtain oil-phase solution；2) by solvent and aqueous phase wetting agent heating for dissolving, aqueous phase solution is obtained；3) successively by aqueous phase solution and oil-phase solution suction reaction pot in the way of vacuum；Add antioxidant homogenizing, obtain semi-finished product solution；4) semi-finished product solution is lowered the temperature, yeast extract and plant extract are added in semi-finished product solution, obtains skin repair compositions；This skin repair compositions, for the skin damaged due to use glucocorticoid, plays reparation horny layer, provides nutrition for epidermis cell, accelerates the fast quick-recovery of epidermis.
Description
Technical field
The present invention relates to a kind of skin repair compositions and preparation method thereof, belong to skin care technical field.
Background technology
In recent years, in both effectiveness cosmetics, the illegal phenomenon adding hormone, of common occurrence.Such as: produce at whitening and speckle dispelling
Product use " hydroquinone+retinoic acid+dexamethasone " or " ammoniated mercury+dexamethasone "；" chloromycetin+ground is used in product for resolving poxes
Sai meter Song "；Anti-anaphylaxis product uses combinations such as " dexamethasone or betamethasones ".What is more, anti-for reducing the allergy of product
Should, in common cosmetics, even all add glucocorticoid.Glucocorticoid can suppress the metabolism of skin, makes substrate
Cell splitting rate slows down, melanocyte secretion melanin reduces, cuticular lipid and protein metabolism be substantially at by
The state of suppression.It is to say, the oldest horny layer peels off, new corneocyte is not had to supplement, in the course of time, skin angle
Matter layer is more and more thinner, easily the most sensitive, dry, rubescent, itch, burn feeling, twinge, locally erythema even " red blood streak " occur.
Summary of the invention
In order to overcome the deficiencies in the prior art, first purpose of the present invention is to provide a kind of skin repair compositions,
This skin repair compositions, for the skin damaged due to use glucocorticoid, plays reparation horny layer, for epidermis cell
Nutrition is provided, accelerates the fast quick-recovery of epidermis.
Realize the purpose of the present invention to reach by adopting the following technical scheme that:
A kind of skin repair compositions, the following component including by weight:
As preferably, described solvent is water.
As preferably, described aqueous phase wetting agent includes following component by weight:
Glycerol 6～13 parts；
Butanediol 4～12 parts.
As preferably, described oil phase emollient includes following component by weight:
As preferably, described emulsifying agent includes following component by weight:
Cetearyl glucoside 2～4 parts；
Cetearyl alcohol 1～6 parts.
As preferably, described antioxidant is tocopherol.
As preferably, described plant extract includes following component by weight:
Herba Schizonepetae extract 5～10 parts；
Herba Violae extract 5～12 parts.
Second object of the present invention is to provide for the preparation method of a kind of above-mentioned skin repair compositions, passes through the party
Skin repair compositions prepared by method, each composition function is given full play to, collaborative skin care.
Realize the purpose of the present invention to reach by adopting the following technical scheme that: a kind of skin repair group as above
The preparation method of compound, comprises the following steps:
1) oil-phase solution is prepared: oil phase emollient and emulsifying agent are placed in vessel in heating and dissolve, and mix homogeneously, obtain
Oil-phase solution；
2) aqueous phase solution is prepared: solvent and aqueous phase wetting agent are placed in vessel in heating and dissolve, and mix homogeneously, obtain water
Phase solution；
3) mixing: preheating reaction pot evacuation, successively by anti-to aqueous phase solution and oil-phase solution suction in the way of vacuum
Answer pot；Aqueous phase solution and oil-phase solution are stirred and after homogenizing, adds antioxidant homogenizing, obtain semi-finished product solution；
4) cooling: semi-finished product solution is cooled to 35～45 DEG C, adds semi-finished product by yeast extract and plant extract
In solution, mix homogeneously, obtain skin repair compositions.
As preferably, step 1) in, when described oil phase emollient and emulsifying agent mixing, heating-up temperature is 80～90 DEG C.
As preferably, step 2) in, when described solvent and the mixing of aqueous phase wetting agent, heating-up temperature is 80～90 DEG C.
The formulation Design Principle of the present invention is as follows:
On the one hand, the skin skin horny layer having a hormonal dependent is thinning, skin fragility, needs to add one layer to skin and prevents
Cuticula, intercepts environmental stimuli, and the present invention uses oil phase emollient, has more preferable isolation effect, pins moisture of skin, for skin
Nutrition is provided, promotes alimentation；Oil phase emollient include tridecyl alcohol stearate, tridecyl alcohol trimellitate, new penta
Glycol dicaprate, Cyclomethicone, ethylhexyl palmitate, hydrogenated olive oil, cocoa seed fat, can prepare
Journey mixes well with other compositions, also can keep giving full play to of each composition function；
On the other hand, need to find the natural substitute having no side effect of hormone, progressively break away from the skin dependence to hormone
Property, the plant extract of the present invention choose treatment xerosis cutis, severe pruritus, inflammation, cicatrix, affected part sepage, abnormal pigment sink
The product, can suppress the inflammatory factor caused because of outside stimulus or genetic factor, significantly improve the immunocompetence of skin self
And antioxidant activity, there is the effect releiving and repairing skin；
Furthermore, in addition it is also necessary to repairing stratum corneum barrier function, the present invention uses antioxidant and yeast extract to promote
Cell metabolism, accelerates cell division, reaches the effect repaired.
Compared to existing technology, the beneficial effects of the present invention is:
1, the present invention is directed to the skin damaged due to use glucocorticoid, play reparation horny layer, for epidermis cell
Nutrition is provided, accelerates the fast quick-recovery of epidermis；
2, the present invention adds yeast extract, is used for skin care industry as by culture propagation product, has promotion new old generation
The function thanked；
3, the composition selected by the present invention has similar physical characteristic, non-volatile when feeding in the way of evacuation, becomes
/ fully dissolve each other, remain each constituent to greatest extent, make skin repair compositions play maximum effect.
Detailed description of the invention
Below, in conjunction with detailed description of the invention, the present invention is described further:
A kind of skin repair compositions, it is characterised in that include following component by weight:
Yeast extract is: by yeast by plasmolysis, will wherein protein, nucleic acid, vitamin be stripped, then will
The material that obtains of extracting through biological enzymolysis, finally obtain rich in active skull cap components such as aminoacid, peptide, nucleotide, vitamin
Yeast extract.
Herba Schizonepetae extract is: the bottom dryly of Herba Schizonepetae is divided into raw material to carry out the product extracted, containing volatile oil, main component
For D-menthone, racemization menthone, there is effect of antibacterial, antiinflammatory and hemostasis.
Herba Violae extract is: Herba Violae herb is the product that raw material carries out extracting, containing glycoside, flavonoid, wax, wax
The esters of acid and unsaturated acids etc., has the effect of heat clearing away, detumescence, antiinflammatory, and Herba Violae extract can be effectively improved in short-term
Skin moisture content and reduction water loss, life-time service can effectively control fat secretion and improve skin elasticity.
The preparation method of above-mentioned skin repair compositions, comprises the following steps:
1) prepare oil-phase solution: oil phase emollient and emulsifying agent are placed in vessel in heating dissolve, heating-up temperature be 80～
90 DEG C, and mix homogeneously, obtain oil-phase solution；
2) aqueous phase solution is prepared: solvent and aqueous phase wetting agent being placed in vessel in heating and dissolves, heating-up temperature is 80～90
DEG C, and mix homogeneously, obtain aqueous phase solution；
3) mixing: preheating reaction pot evacuation, successively by anti-to aqueous phase solution and oil-phase solution suction in the way of vacuum
Answer pot；Aqueous phase solution and oil-phase solution are stirred and after homogenizing, adds antioxidant homogenizing, obtain semi-finished product solution；
4) cooling: semi-finished product solution is cooled to 35～45 DEG C, adds semi-finished product by yeast extract and plant extract
In solution, mix homogeneously, obtain skin repair compositions.
The mode of present invention evacuation feeds, and the boiling point of each composition will not be too low, will not vaporize during vacuum feed, it is ensured that
Each composition is able to well into reaction pot, and mix homogeneously reacting completely.
Embodiment 1～3
The skin repair compositions of embodiment 1～3 includes composition as shown in table 1:
The component proportion of table 1 embodiment 1～3
The preparation method of embodiment 1～3 comprises the following steps:
1) oil-phase solution is prepared: oil phase emollient and emulsifying agent are placed in vessel in heating and dissolve, and mix homogeneously, obtain
Oil-phase solution；
2) aqueous phase solution is prepared: solvent and aqueous phase wetting agent are placed in vessel in heating and dissolve, and mix homogeneously, obtain water
Phase solution；
3) mixing: preheating reaction pot evacuation, successively by anti-to aqueous phase solution and oil-phase solution suction in the way of vacuum
Answer pot；Aqueous phase solution and oil-phase solution are stirred and after homogenizing, adds antioxidant homogenizing, obtain semi-finished product solution；
4) cooling: semi-finished product solution is cooled to 35～45 DEG C, adds semi-finished product by yeast extract and plant extract
In solution, mix homogeneously, obtain skin repair compositions.
In the preparation method of embodiment 1,
Step 1) in, when oil phase emollient and emulsifying agent mixing, heating-up temperature is 90 DEG C；
Step 2) in, when described solvent and the mixing of aqueous phase wetting agent, heating-up temperature is 80 DEG C；
Step 4) in, semi-finished product solution is cooled to 38 DEG C；
In the preparation method of embodiment 2,
Step 1) in, when oil phase emollient and emulsifying agent mixing, heating-up temperature is 85 DEG C；
Step 2) in, when described solvent and the mixing of aqueous phase wetting agent, heating-up temperature is 85 DEG C；
Step 4) in, semi-finished product solution is cooled to 42 DEG C；
In the preparation method of embodiment 3,
Step 1) in, when oil phase emollient and emulsifying agent mixing, heating-up temperature is 80 DEG C；
Step 2) in, when described solvent and the mixing of aqueous phase wetting agent, heating-up temperature is 88 DEG C.
Step 4) in, semi-finished product solution is cooled to 45 DEG C；
The skin repair compositions of embodiment 1～3 is carried out clinical experiment contrast, and clinical experiment condition is: volunteer 120
Name, age 20-45 year, be randomly divided into 4 groups, often organize 30 people, volunteer is the personnel with hormonal dependent skin, and affected part has
Have rubescent, itch, burn feeling, twinge or the symptom of red blood streak, during testing, do not smear other any skin protections at test position
Product, smears once, the most persistently surrounding every day sooner or later respectively.
Contrast on effect: comparative example 1 only smears vaseline for every day, skin conditions of statistics is improved and skin weekly
The number that situation is deteriorated, experimental result is as shown in table 2,
Table 2 comparative example 1 and the testing result of embodiment 1～3
| Comparative example 1 | Embodiment 1 | Embodiment 2 | Embodiment 3 | |
| Improvement number | 8 | 25 | 27 | 23 |
| Variation number | 5 | 2 | 0 | 1 |
For a person skilled in the art, can technical scheme as described above and design, make other each
Plant corresponding change and deformation, and all these changes and deforms the protection model that all should belong to the claims in the present invention
Within enclosing.
Claims (9)
1. a skin repair compositions, it is characterised in that include following component by weight:
2. skin repair compositions as claimed in claim 1, it is characterised in that: described aqueous phase wetting agent includes by weight
Following component:
Glycerol 6～13 parts；
Butanediol 4～12 parts.
3. skin repair compositions as claimed in claim 1, it is characterised in that: described oil phase emollient includes by weight
Following component:
4. skin repair compositions as claimed in claim 1, it is characterised in that: described emulsifying agent include by weight with
Lower composition:
Cetearyl glucoside 2～4 parts；
Cetearyl alcohol 1～6 parts.
5. skin repair compositions as claimed in claim 1, it is characterised in that: described antioxidant is tocopherol.
6. skin repair compositions as claimed in claim 1, it is characterised in that: described plant extract includes by weight
Following component:
Herba Schizonepetae extract 5～10 parts；
Herba Violae extract 5～12 parts.
7. the preparation method of a skin repair compositions as claimed in claim 1, it is characterised in that: comprise the following steps:
1) oil-phase solution is prepared: oil phase emollient and emulsifying agent are placed in vessel in heating and dissolve, and mix homogeneously, obtain oil phase
Solution；
2) aqueous phase solution is prepared: solvent and aqueous phase wetting agent are placed in vessel in heating and dissolve, and mix homogeneously, obtain aqueous phase molten
Liquid；
3) mixing: preheating reaction pot evacuation, successively by aqueous phase solution and oil-phase solution suction reaction pot in the way of vacuum；
Aqueous phase solution and oil-phase solution are stirred and after homogenizing, adds antioxidant homogenizing, obtain semi-finished product solution；
4) cooling: semi-finished product solution is cooled to 35～45 DEG C, adds semi-finished product solution by yeast extract and plant extract
In, mix homogeneously, obtain skin repair compositions.
8. the preparation method of skin repair compositions as claimed in claim 6, it is characterised in that: step 1) in, described oil phase
When emollient and emulsifying agent mixing, heating-up temperature is 80～90 DEG C.
9. the preparation method of skin repair compositions as claimed in claim 6, it is characterised in that: step 2) in, described solvent
When mixing with aqueous phase wetting agent, heating-up temperature is 80～90 DEG C.
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| CN108852975A (en) * | 2018-08-23 | 2018-11-23 | 璧电健 | Pure natural striae of pregnancy remediation composition |
| CN109771350A (en) * | 2019-03-19 | 2019-05-21 | 广州睿森生物科技有限公司 | A kind of skin barrier remediation composition, Essence and preparation method thereof |
| CN111214418A (en) * | 2020-03-13 | 2020-06-02 | 佛山市奥姿美生物科技有限公司 | Efficient barrier repair composition and application thereof |
| CN113662870A (en) * | 2021-06-21 | 2021-11-19 | 广州华淼生物科技研究院有限公司 | Cream water composition and preparation method thereof |
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| CN111214418A (en) * | 2020-03-13 | 2020-06-02 | 佛山市奥姿美生物科技有限公司 | Efficient barrier repair composition and application thereof |
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