CN106264556A - A kind of Fiber Optic Sensor Based on Surface Plasmon Resonance inserting blood vessel detection - Google Patents
A kind of Fiber Optic Sensor Based on Surface Plasmon Resonance inserting blood vessel detection Download PDFInfo
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- CN106264556A CN106264556A CN201610959088.9A CN201610959088A CN106264556A CN 106264556 A CN106264556 A CN 106264556A CN 201610959088 A CN201610959088 A CN 201610959088A CN 106264556 A CN106264556 A CN 106264556A
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- 239000000835 fiber Substances 0.000 title claims abstract description 131
- 210000004204 blood vessel Anatomy 0.000 title claims abstract description 18
- 238000001514 detection method Methods 0.000 title claims abstract description 13
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 title claims abstract description 11
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 15
- 229910052737 gold Inorganic materials 0.000 claims description 15
- 239000010931 gold Substances 0.000 claims description 15
- 238000001228 spectrum Methods 0.000 claims description 8
- 239000000427 antigen Substances 0.000 claims description 5
- 102000036639 antigens Human genes 0.000 claims description 5
- 108091007433 antigens Proteins 0.000 claims description 5
- 230000003595 spectral effect Effects 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- 230000037431 insertion Effects 0.000 claims 4
- 238000003780 insertion Methods 0.000 claims 4
- 238000005253 cladding Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000013307 optical fiber Substances 0.000 abstract description 19
- 230000008901 benefit Effects 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 4
- 238000003745 diagnosis Methods 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 238000012827 research and development Methods 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 12
- 230000035945 sensitivity Effects 0.000 description 5
- 238000005286 illumination Methods 0.000 description 4
- 239000012528 membrane Substances 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000012491 analyte Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010804 cDNA synthesis Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 238000000985 reflectance spectrum Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Heart & Thoracic Surgery (AREA)
- Optics & Photonics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention discloses a kind of Fiber Optic Sensor Based on Surface Plasmon Resonance inserting blood vessel detection, including light source, Twin-Core Fiber Coupler and spectrogrph, described light source is connected with Twin-Core Fiber Coupler by a single-mode fiber, described Twin-Core Fiber Coupler is connected with twin-core fiber, described Twin-Core Fiber Coupler is connected with spectrogrph by a single-mode fiber, the reflection termination of described twin-core fiber includes that reflecting surface and sensitive face, described reflecting surface have two, is symmetricly set on sensitive face both sides；By Twin-Core Fiber Coupler, two single-mode fibers are coupled with twin-core fiber two fibre core, the incident reception with reflection light of light can be carried out with one end at twin-core fiber, twin-core fiber other end is reflection termination, there is reflective spr sensor effect, achieve the combination of spr sensor and diameter 125 μm optical fiber advantage, can be inserted into blood vessel on-line checking, highly sensitive, real-time, in the field such as medicament research and development and medical diagnosis, there is huge application potential.
Description
Technical field
The invention belongs to analysis, fields of measurement, be specifically related to a kind of optical fiber surface plasmon body inserting blood vessel detection and be total to
Vibration sensor.
Background technology
Surface plasma resonance biosensor has been increasingly used for bio-molecular interaction, chemistry and life
In the detection of thing analyte response.In these areas, surface plasmon resonance biosensor can be to analyte (such as antigen, DNA) and be fixed on
The interaction between specific binding body (such as antibody, complementary DNA) on spr sensor metal film is measured in real time.
SPR sensorgram platform is normally based on Kretschmann structure, thin high-conductive metal (commonly gold or silver) layer cover
Cover and form at prism surface.The characteristic of its reflectance spectrum is extremely sensitive to the refractive index closing on metal level lateral media.Phase
Ratio needs fluid handling system to have small-sized to sensor probe sample presentation, optical fiber pickup probe in the SPR of space prism structure
Change, the advantage in solution to be measured can be immersed directly in.
Research about optical fiber at present focuses mostly on and is utilizing multimode fibre, and multiple SPR based on multimode fibre structure passes
Sensor is suggested and has carried out experimentation.C Ronot-Trioli (Sensors and Actuators A Physical,
1996,54 (1): 589-593) et al. multimode fibre on-line normalization formula spr sensor is achieved.RC Jorgenson(Sensors
And Actuators A Physical, 1994,43 (93): 44-48) et al. achieve end reflection formula multimode fibre SPR to pass
Sensor.Woo-Hu Tsai (Optics Letters, 2005,30 (17): 2209-2211) et al. achieves side rubbing down structure
(D type) multimode fibre spr sensor.Although multimode fibre SPR probe has making easily, the advantages such as light source injecting power is big.
But, the incident angle of light in multimode fibre is uncontrollable, makes incident illumination reach SPR altogether to meet Kretschmann structure
Shake angle, generally uses and completely injects form and cover certain angular range, and the resonance curve finally obtained is by multiple angles
Incident light activated resonance curve is formed by stacking, thus causes the broadening of resonance curve, have impact on sensitivity and the essence of sensor
Degree, is extremely difficult to the sensitivity of lens type spr sensor.Legacy multimode fiber spr sensor cannot adjust light source incidence angle,
Under the resonance curve broadening that multi-angle incident illumination causes and sensitivity, degradation problem is that optical fiber SPR sensor is the most practical must
The difficult problem that must solve.
Summary of the invention
In view of this, it is an object of the invention to provide one can conveniently adjust light source incidence angle and have highly sensitive
The Fiber Optic Sensor Based on Surface Plasmon Resonance of degree.
For reaching above-mentioned purpose, the present invention provides following technical scheme: a kind of optical fiber surface inserting blood vessel detection etc. from
Daughter resonance sensor, including light source, Twin-Core Fiber Coupler and spectrogrph, described light source passes through a single-mode fiber and twin-core
Fiber coupler connection the light sent by light source inject in single-mode fiber, and described Twin-Core Fiber Coupler is connected with twin-core fiber
Leading to and inject in a fibre core in twin-core fiber by the light in single-mode fiber, light occurs anti-in the reflection end of twin-core fiber
Penetrating, another fibre core of twin-core fiber be transferred to Twin-Core Fiber Coupler, described Twin-Core Fiber Coupler passes through a list
Mode fiber connects with spectrogrph, at the reflected light pass in another fibre core to spectrogrph；The reflection end of described twin-core fiber
Head includes that reflecting surface and sensitive face, described reflecting surface have two, is symmetricly set on sensitive face both sides.
Further, described light source is spectral width super continuous spectrums wide spectrum light source between 450nm～2400nm.
Further, a diameter of 9 μm of described single-mode fiber.
Further, the core diameter 3-6 μm of described twin-core fiber, two fibre cores are symmetrical and spacing is 50～55 μm, bag
Layer external diameter is 125 μm, and numerical aperture is 0.12.
Further, described reflecting surface is coated with the thick reflection gold film of 300nm, described sensitive face is combined and is coated with 50nm thickness
Sensing gold film and antigen.
The beneficial effects of the present invention is:
1, the big core diameter multimode fibre SPR probe of tradition, is SPR resonance angle for making gold film mate with transmission light angle, thus
Realize Kretchmann prism structure, higher order mode need to have been encouraged in big core diameter multimode fibre, but there is higher order mode and mix
Close noise, be difficult to adjust and gold film angle, the problems such as simulation calculation is the most difficult, and sensitivity is low, and the present invention is by twin-core
It is coated with gold film on fiber reflection termination, utilizes the basic mode in single-mode dual-core optical fiber to realize Kretchmann prism structure, efficient solution
The certainly masty bottleneck problem of above optical fiber；
2, the reflection termination of different angles can be ground by optical fiber lapping technology, the adjustment at light source incidence angle can be realized；
3, by Twin-Core Fiber Coupler, two single-mode fibers are coupled with twin-core fiber two fibre core, can be at twin-core fiber
Carrying out the incident reception with reflection light of light with one end, twin-core fiber other end is reflection termination, has reflective spr sensor
Effect, it is easy to use, the huge applications advantages such as small space can be entered；
4, SPR sensorgram probe effect is played in twin-core fiber reflection termination, it is achieved that spr sensor and diameter 125 μm optical fiber
The combination of advantage, can be inserted into blood vessel on-line checking, highly sensitive, real-time, has in the field such as medicament research and development and medical diagnosis
There is huge application potential.
Accompanying drawing explanation
In order to make the purpose of the present invention, technical scheme and beneficial effect clearer, the present invention provides drawings described below to carry out
Illustrate:
Fig. 1 is the structural representation of the present invention；
Fig. 2 is Twin-Core Fiber Coupler optic path figure；
Fig. 3 is the structural representation of twin-core fiber reflection termination.
Detailed description of the invention
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described in detail.
As it can be seen, the Fiber Optic Sensor Based on Surface Plasmon Resonance inserting blood vessel detection in the present invention, including light source
1, Twin-Core Fiber Coupler 2 and spectrogrph 3, described light source connected with Twin-Core Fiber Coupler 2 by single-mode fiber 4 and incite somebody to action
The light that light source sends injects in single-mode fiber 4, and described Twin-Core Fiber Coupler 2 is connected with twin-core fiber 5 and by single-mode fiber 4
Interior light injects in a fibre core in twin-core fiber 5, and light reflects in the reflection end of twin-core fiber 5, enters twin-core
In another fibre core of optical fiber 5 and be transferred at Twin-Core Fiber Coupler 2, described Twin-Core Fiber Coupler 2 is by a single mode
Optical fiber 4 connects with spectrogrph 3, at the reflected light pass in another fibre core to spectrogrph 3；The reflection of described twin-core fiber 5
Termination includes reflecting surface 51 and sensitive face 52, and described reflecting surface 51 has two, is symmetricly set on sensitive face 52 both sides.
Concrete, the light of light source 1 injects single-mode fiber 4, by Twin-Core Fiber Coupler 2, light injects twin-core fiber 5
In one fibre core, P polarization light enters after there is three total reflections on the two symmetric reflective faces 51 and sensitive face 52 of twin-core fiber
In another one fibre core, wherein, there is to excite during total reflection SPR phenomenon in second time on sensitive face 52, reflection light is by twin-core light
Fine 5 another fibre core transmission detect sensing spectrum to spectrogrph 3.By compound different types of in the sensing membrane of sensitive face 52
Antigen, can detect the different antibodies in blood vessel 6 to be detected.Twin-core fiber 5 herein reflects termination and plays SPR sensorgram
Probe effect, it is achieved that spr sensor and the combination of diameter 125 μm optical fiber advantage, can be inserted into blood vessel on-line checking, sensitivity
Height, real-time, in the field such as medicament research and development and medical diagnosis, there is huge application potential.
In the present embodiment, described light source is spectral width super continuous spectrums wide spectrum light source between 450nm～2400nm.Single
A diameter of 9 μm of mode fiber；The core diameter 3-6 μm of twin-core fiber, two fibre cores are symmetrical and spacing is 50～55 μm, covering
External diameter is 125 μm, and numerical aperture is 0.12.It is coated with the thick reflection gold film of 300nm on reflecting surface, described sensitive face is combined and is coated with
The sensing gold film of 50nm thickness and antigen.
Twin-Core Fiber Coupler in the present embodiment is biconvex lens fine adjustment mechanism.
Reflection termination in twin-core fiber 5 is prepared by optical fiber lapping method.Concrete, twin-core fiber end face is cut flat with, clamping
In optical fiber lapping system, two fibre cores are passed through white light simultaneously, it is simple to positioned two fibres of optical fiber by the CCD of grinding system
Core.Axially rotating twin-core fiber, make two fibre core place straight lines be perpendicular to abrasive disk, lower press polish is fine so that it is become α with abrasive disk
Angle, is ground.When being ground to projected depth, above lift optical fiber, vertically by fiber spinning 180 °, again descend press polish fine to
Abrasive disk is at an angle to be ground.When second time is ground, in having ground side fibre core, it is passed through single-frequency laser, at opposite side
Fibre core is monitored light intensity, when light intensity reaches maximum, stops grinding, the reflection termination that light becomes at twin-core fiber end surface grinding
(shape is approximately conical butt) place, through triple reflection, has returned to reflection light from incident fibre core and has collected fibre core.
By grind complete twin-core fiber cone angle sound end towards on be placed on below ion sputtering instrument gold target, be coated with
500nm thick gold membrane forms reflectance coating 51, it is ensured that light can be reflexed to outgoing fibre core by incident fibre core in aqueous.Grind with optical fiber
Grinding system carefully removes cone angle probe end face gold film, and is coated with 50nm thick gold membrane, as surface plasma at cone angle probe end face
Resonance body film.
After super continuum source 1 is injected single-mode fiber 4, inject twin-core fiber 5 incident illumination by Twin-Core Fiber Coupler 2
Fibre core, there is triple reflection at SPR microsensor probe (i.e. reflecting termination) place in incident illumination, and in second time at cone angle sound end
Surface plasma body resonant vibration is there is during the reflection of face.The reflection light of probe enters twin-core fiber 5 mirror based fiber optica core, again by twin-core
Fiber coupler 2 is sent into spectrogrph 3 and is gathered reflection loss spectrum.The 50nm gold film of sensitive face 52 is combined different types of anti-
Former, the different antibodies in blood vessel 6 to be detected can be detected.Twin-core fiber SPR sensorgram probe (reflection termination) is compounded in
Insert blood vessel 6 to be measured after on syringe needle, thus formed a kind of highly sensitive, real-time, can be inserted into the optical fiber surface of blood vessel detection
Plasma resonance sensing equipment.
Finally illustrate, preferred embodiment above only in order to technical scheme to be described and unrestricted, although logical
Cross above preferred embodiment the present invention to be described in detail, it is to be understood by those skilled in the art that can be
In form and it is made various change, without departing from claims of the present invention limited range in details.
Claims (5)
1. the Fiber Optic Sensor Based on Surface Plasmon Resonance inserting blood vessel detection, it is characterised in that: include light source, twin-core light
Fine bonder and spectrogrph, the light that described light source is connected with Twin-Core Fiber Coupler by a single-mode fiber and sent by light source
In injection single-mode fiber, described Twin-Core Fiber Coupler is connected with twin-core fiber and the light in single-mode fiber is injected twin-core light
In a fibre core in fibre, light reflects in the reflection end of twin-core fiber, another fibre core of twin-core fiber transmit
To Twin-Core Fiber Coupler, described Twin-Core Fiber Coupler is connected with spectrogrph by a single-mode fiber, and another is fine
Reflected light pass in core is at spectrogrph；The reflection termination of described twin-core fiber includes reflecting surface and sensitive face, described reflection
Face has two, is symmetricly set on sensitive face both sides.
The Fiber Optic Sensor Based on Surface Plasmon Resonance of insertion blood vessel the most according to claim 1 detection, it is characterised in that:
Described light source is spectral width super continuous spectrums wide spectrum light source between 450nm～2400nm.
The Fiber Optic Sensor Based on Surface Plasmon Resonance of insertion blood vessel the most according to claim 1 detection, it is characterised in that:
A diameter of 9 μm of described single-mode fiber.
The Fiber Optic Sensor Based on Surface Plasmon Resonance of insertion blood vessel the most according to claim 1 detection, it is characterised in that:
The core diameter 3-6 μm of described twin-core fiber, two fibre cores are symmetrical and spacing is 50～55 μm, and cladding outer diameter is 125 μm, number
Value aperture is 0.12.
The Fiber Optic Sensor Based on Surface Plasmon Resonance of insertion blood vessel the most according to claim 1 detection, it is characterised in that:
The thick reflection gold film of 300nm it is coated with, the compound sensing gold film being coated with 50nm thickness and antigen on described sensitive face on described reflecting surface.
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| CN201610959088.9A CN106264556A (en) | 2016-11-03 | 2016-11-03 | A kind of Fiber Optic Sensor Based on Surface Plasmon Resonance inserting blood vessel detection |
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| CN201610959088.9A CN106264556A (en) | 2016-11-03 | 2016-11-03 | A kind of Fiber Optic Sensor Based on Surface Plasmon Resonance inserting blood vessel detection |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107132201A (en) * | 2017-07-12 | 2017-09-05 | 广西师范大学 | The long-range pH value monitoring device of laser type |
| CN107300538A (en) * | 2017-08-28 | 2017-10-27 | 重庆三峡医药高等专科学校 | A kind of unicellular accurate test experience device based on optical fiber |
| CN109187440A (en) * | 2018-08-06 | 2019-01-11 | 天津大学 | Single mode-based on mode excitation lacks mould/multimode fibre spr sensor |
| CN110554462A (en) * | 2019-08-07 | 2019-12-10 | 中国电子科技集团公司第四十一研究所 | Small multi-mode light source |
| CN113295624A (en) * | 2021-04-25 | 2021-08-24 | 上海工程技术大学 | Optical fiber SPR sensing device for detecting multiple tumor markers |
| CN113671632A (en) * | 2021-08-26 | 2021-11-19 | 桂林电子科技大学 | Arc-shaped cone fiber end full reflector based on multi-core optical fiber and preparation method thereof |
| CN116492051A (en) * | 2023-03-28 | 2023-07-28 | 北京信息科技大学 | Spiral optical fiber shape sensing system for vascular guide wire |
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| CN206453776U (en) * | 2016-11-03 | 2017-09-01 | 重庆三峡医药高等专科学校 | A kind of Fiber Optic Sensor Based on Surface Plasmon Resonance for inserting blood vessel detection |
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2016
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107132201A (en) * | 2017-07-12 | 2017-09-05 | 广西师范大学 | The long-range pH value monitoring device of laser type |
| CN107300538A (en) * | 2017-08-28 | 2017-10-27 | 重庆三峡医药高等专科学校 | A kind of unicellular accurate test experience device based on optical fiber |
| CN109187440A (en) * | 2018-08-06 | 2019-01-11 | 天津大学 | Single mode-based on mode excitation lacks mould/multimode fibre spr sensor |
| CN110554462A (en) * | 2019-08-07 | 2019-12-10 | 中国电子科技集团公司第四十一研究所 | Small multi-mode light source |
| CN113295624A (en) * | 2021-04-25 | 2021-08-24 | 上海工程技术大学 | Optical fiber SPR sensing device for detecting multiple tumor markers |
| CN113671632A (en) * | 2021-08-26 | 2021-11-19 | 桂林电子科技大学 | Arc-shaped cone fiber end full reflector based on multi-core optical fiber and preparation method thereof |
| CN113671632B (en) * | 2021-08-26 | 2022-10-25 | 桂林电子科技大学 | Arc-shaped cone fiber end full reflector based on multi-core optical fiber and preparation method thereof |
| CN116492051A (en) * | 2023-03-28 | 2023-07-28 | 北京信息科技大学 | Spiral optical fiber shape sensing system for vascular guide wire |
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