CN106236285A - Breast tumor positioner - Google Patents

Abstract

The invention provides a breast tumor localization device, which relates to the technical field of medical equipment; Take the fixed tail of the tumor tissue; the pushing device is used to push the locator to a predetermined position; before the stage of breast tumor radiotherapy or chemotherapy, the locator is pushed into the tumor by the pushing device, and fixed by the locator The tail fixes the locator in the mass tissue. The mass tissue shrinks or disappears during radiotherapy or chemotherapy (it cannot be touched clinically and the image cannot be displayed). When the tumor is resected later, the head of the locator can be developed under image guidance , so that the surgeon can accurately and quickly find the location of the tumor and remove it.

Description

Breast Tumor Localization Device

technical field

The present invention relates to the technical field of medical devices; in particular, it relates to a marker that is placed on the tumor tissue as a marker before chemotherapy or radiotherapy of breast tumor tissue, and is used to develop and locate the inconspicuous tumor site after chemotherapy or radiotherapy during resection. things.

Background technique

Breast cancer is one of the common diseases in women. Regarding the treatment of breast tumors, the best way to take it at present is radiotherapy or chemotherapy first, and then resection.

Chemotherapy before surgery is called "neoadjuvant chemotherapy," and is sometimes called "initial chemotherapy" or "induction chemotherapy." This treatment method first appeared in the 1970s. The original purpose was to allow some inoperable patients to undergo chemotherapy to shrink breast tumors and regain the opportunity for radical surgery. At present, this purpose is still the main purpose of neoadjuvant chemotherapy, and it has become the most standard treatment for locally advanced breast cancer and inflammatory breast cancer.

With the development of medicine, breast-conserving surgery has been affirmed and welcomed, and the role of neoadjuvant chemotherapy has also been expanded. Some patients have a large breast lump when they are first diagnosed. Even if these patients can undergo radical resection, they will lose the opportunity for breast-conserving surgery; or even if they are forced to undergo breast-conserving surgery, the shape of the postoperative breast is severely deformed and cannot be aesthetically pleasing. Effect. For these patients, if neoadjuvant chemotherapy is given before the operation, the breast tumor will shrink significantly or even disappear, then the patient will have the opportunity to preserve the breast. Therefore, another important purpose of neoadjuvant chemotherapy is to strive for the success rate of breast-conserving surgery for patients with large tumors.

Of course, there are still some breast cancers with particularly high malignancy and metastasis soon, and even some patients are found to have metastasis during the postoperative recovery period. Surgical treatment of this kind of patients is very poor, systemic control of chemotherapy is the first choice for these patients, and these patients have also become the beneficiary population of neoadjuvant chemotherapy. Chemotherapy is used to control the tumor throughout the body to avoid hematogenous metastasis. After the systemic control is good, try to resect the local breast tumor to further improve the treatment effect.

Neoadjuvant chemotherapy also has an additional role, which is to visually judge the efficacy of chemotherapy and guide postoperative chemotherapy. Before surgery, patients undergo chemotherapy. Since the tumor has not been resected, the curative effect of the chemotherapy regimen on the patient can be judged intuitively by measuring the size of the tumor. Chemotherapy after surgery, since there is no tumor to visually judge the curative effect, the selection of chemotherapy drugs and regimens has certain uncertainties. The intuitive effect of preoperative neoadjuvant chemotherapy can just guide the choice of postoperative chemotherapy.

Due to the above purposes, generally, we will perform preoperative chemotherapy or radiotherapy before tumor resection for patients with breast tumors; however, after preoperative chemotherapy or radiotherapy, breast tumor tissue will be significantly reduced or displayed (clinically unpalpable) And the image cannot be displayed), which makes the target of the pre-resected breast tumor tissue unclear in the later surgical treatment, which brings difficulties to the operation.

Contents of the invention

The present invention aims to solve one of the above-mentioned technical problems in the prior art at least to a certain extent.

For this reason, the object of the present invention is to propose a breast tumor localization device, which is implanted into the tumor tissue as a marker of the tumor position during the preoperative chemotherapy or radiotherapy stage of the breast tumor, and the tumor tissue shrinks or becomes inconspicuous during the chemotherapy or radiotherapy treatment After the resection operation, the position of the tumor can be found through the marks provided by the positioning device, and the shrunk tumor tissue can be excised.

According to a breast tumor localization device provided by the present invention, the localization device comprises:

A locator, the locator has a head that can be developed under image guidance and a fixed tail connected to the head that can grab tumor tissue; and

A pushing device, the pushing device is used to push the locator to a predetermined position.

The locating device provided by the present invention includes a locator and a pushing device. The pushing device is used to push the locator to the breast tumor tissue and fix it in the tumor tissue. The locator includes a head developed under image guidance and a The fixed tail of the tumor tissue; for this reason, the locator is pushed into the tumor by the push device before the breast tumor radiotherapy or chemotherapy stage, and the locator is fixed in the tumor tissue through the fixed tail of the locator. During the chemotherapy treatment, it shrinks or disappears (it cannot be touched clinically and cannot be displayed on the image). When the tumor is resected later, the head of the locator can be visualized under the guidance of the image, so that the operator can accurately and quickly find the location of the tumor and perform the resection.

According to the positioning device provided by the present invention, it may also have the following additional technical features.

According to some embodiments of the present invention, the pushing device includes a sleeve and a push rod, the sleeve includes a front port and a rear port, and the front port is configured as an oblique section structure inclined relative to the axis of the sleeve The front end of the push rod is arranged in the casing in a manner that can be moved along the axial direction of the casing; the locator is placed in the casing and can be moved axially along the casing when the push rod When moving out from the anterior port into the breast mass tissue.

According to some embodiments of the present invention, the head has a sharp end and an extension end extending along the sharp end, and the fixed tail is disposed on the extension end; when the locator is placed in the casing, The pointed end faces the front port, and the extended end faces the rear port.

According to some embodiments of the present invention, the head is a pyramid structure, and the fixed tail is a grip formed by a metal wire extending from the top to the bottom of the pyramid along its ridgeline.

According to some embodiments of the present invention, the head is a hemispherical structure, the fixed tail is arranged on the bottom surface of the head, the spherical surface of the head faces the front port, and the bottom surface of the head faces the described backport.

According to some embodiments of the present invention, the fixed tail is a grasping grip formed by at least two metal wires, the metal wires include a fixed end connected to the circumference of the bottom surface and a free end, and the metal wires The fixed end extends outwards and is rolled up, and the free end faces the ball center of the head.

According to some embodiments of the present invention, the push device includes a push rod, the push rod includes a push end and a connecting end, and the end of the connecting end is provided with an internal thread; the positioner includes a connecting rod, the The connecting rod is provided with an external thread adapted to the internal thread of the push rod; the external thread of the connecting rod can be connected with the internal thread of the push rod to connect the positioner to the connecting end of the push rod; The connecting rod is fixed on the head or the fixed tail.

According to some embodiments of the present invention, the head is a hemispherical structure; the fixed tail is a grab formed by at least two metal wires, and the grab includes a fixed end connected to a point on the circumference of the bottom surface and a free end, the grabbing is arranged such that the free end extends towards the top of the head and the axial distance from the head gradually increases; the connecting rod extends along the axial direction of the head fixed to the bottom surface of the head.

According to some embodiments of the present invention, the head has scratches or rough surfaces for easy identification by development.

According to some embodiments of the present invention, the head is made of titanium alloy material, and the fixed tail is made of memory metal material.

Additional aspects and advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.

The specific implementation of the present invention will be further elaborated below in conjunction with the accompanying drawings and specific embodiments.

Description of drawings

Fig. 1 is the overall structure schematic diagram of the first embodiment of the present invention;

Fig. 2 is an axonometric view when the locator of the first embodiment of the present invention is placed in the casing;

Fig. 3 is a perspective view of the positioner of the first embodiment of the present invention;

4 is a schematic diagram of the overall structure of the second embodiment of the present invention;

Fig. 5 is an axonometric view when the locator of the second embodiment of the present invention is placed in the casing;

6 is a perspective view of a positioner according to a second embodiment of the present invention;

7 is a schematic diagram of the overall structure of the third embodiment of the present invention;

8 is an isometric view of a positioner according to a third embodiment of the present invention;

Fig. 9 is a perspective view of a positioner according to a third embodiment of the present invention.

In the first embodiment:

Locator 100;

head 110;

sharp end 111;

extension 112;

fixed tail 120;

grab grab 121;

scratch 130;

push device 200;

Sleeve 210;

front port 211;

back port 212;

push rod 220;

In the second embodiment:

Locator 400;

head 410;

bottom surface 411;

fixed tail 420;

grab grab 421;

scratch 430;

Pushing device 500;

Sleeve 510;

front port 511;

backport 512;

push rod 520;

In the third embodiment:

Locator 700;

head 710;

bottom surface 711;

fixed tail 720;

Grab grab 721;

connecting rod 730;

External thread 731;

scratch 740;

Pushing device 800;

push rod 810;

push end 811;

connection terminal 812;

Internal thread 8121.

detailed description

Embodiments of the present invention are described in detail below, examples of which are shown in the drawings, wherein the same or similar reference numerals designate the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the figures are exemplary and are intended to explain the present invention and should not be construed as limiting the present invention.

In describing the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Orientation or position indicated by "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. The relationship is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, therefore It should not be construed as a limitation of the present invention.

In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, a feature defined as "first" and "second" may explicitly or implicitly include one or more of these features. In the description of the present invention, "plurality" means two or more, unless otherwise specifically defined.

In the present invention, unless otherwise clearly specified and limited, terms such as "installation", "connection", "connection" and "fixation" should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection , or integrally connected; it may be mechanically connected or electrically connected; it may be directly connected or indirectly connected through an intermediary, and it may be the internal communication of two components. Those of ordinary skill in the art can understand the specific meanings of the above terms in the present invention according to specific situations.

According to a breast tumor localization device provided by the present invention, the localization device includes a localizer 100, 400, 700 and a pushing device 200, 500, 800; wherein, the localizer 100, 400, 700 has a The developed head 110, 410, 710 and the fixed tail 120, 420, 720 connected to the head 110, 410, 710 can grasp the mass tissue; the pushing device 200, 500, 800 is used to push the The locator 100, 400, 700 is pushed to a predetermined position.

It should be noted that, in the above-mentioned embodiments, the heads 110, 410, and 710 that can be developed under image guidance include ultrasound image guidance or X-ray irradiation guidance, that is, ultrasound image guidance or X-ray guidance Said head 110, 410, 710 has the property of developing under the guidance of ray irradiation.

The positioning device provided by the present invention includes a positioner 100, 400, 700 and a pushing device 200, 500, 800, and the pushing device 200, 500, 800 is used to push the positioner 100, 400, 700 to the breast tumor tissue and fix it on the tumor In the tissue, the locator 100, 400, 700 includes a head 110, 410, 710 developed under image guidance and a fixed tail 120, 420, 720 for grasping mass tissue; Before the stage, push the locator 100, 400, 700 into the tumor through the pushing device 200, 500, 800, and fix the locator 100, 400, 700 through the fixed tail 120, 420, 720 of the locator 100, 400, 700 In the mass tissue, the mass tissue shrinks or disappears during radiotherapy or chemotherapy treatment (clinically not palpable and the image cannot be displayed), and when the tumor is resected later, the head 110, 410, 710 of the locator 100, 400, 700 can Under the guidance of image development, it is convenient for the surgeon to accurately and quickly find the location of the tumor and perform resection.

Fig. 1-Fig. 3 have shown the main technical content of the first embodiment of the present invention, and in this embodiment, described pushing device 200 comprises sleeve tube 210 and a push rod 220, and described sleeve tube 210 comprises front port 211 and a rear port 212, the front port 211 is configured as an oblique cut surface structure inclined relative to the axis of the sleeve 210; the front end of the push rod 220 is inside the sleeve 210 so that it can Arranged in a pushing manner; the locator 100 is placed in the sleeve 210 and can be moved out from the front port 211 into the breast mass tissue when the push rod 220 moves axially along the sleeve 210 .

In this embodiment, the front port 211 of the cannula 210 has an oblique section that is inclined relative to the axis of the cannula 210, which means that the front port 211 of the cannula 210 forms an incision with an oblique section, and the locator 100 is placed on the tumor tissue When inside, after local anesthesia is performed on the human body, the front port 211 of the cannula 210 can be directly formed on the breast to place the locator 100 on the mass tissue through an incision.

In the specific operation, the positioner 100 is placed in the sleeve 210 through the rear port 212 of the sleeve 210, and the positioner 100 moves from the rear port 212 of the sleeve 210 to the front of the sleeve 210 when the push rod 220 is pushed. port 211, and move out from the front port 211 into the mass tissue.

In this embodiment, the head 110 has a sharp end 111 and an extension end 112 extending along the sharp end 111, the fixed tail 120 is arranged on the extension end 112; the positioner 100 is placed on the When inside the cannula 210 , the pointed end 111 faces the front port 211 , and the extended end 112 faces the rear port 212 .

In this embodiment, as shown in FIGS. 2-3 , the sharp end 111 of the head 110 is convenient to be placed in the tumor tissue. When the positioner 100 is placed, the sharp end 111 of the head 110 faces the front port 211 of the cannula 210 , the extension end 112 of the head 110 faces the rear port 212 of the casing 210, when the pushing device 200 pushes the positioner 100, the sharp end 111 of the head 110 guides the head along the direction in which the rear port 212 of the casing 210 extends toward the front port 211 The extension end 112 of the part 110 moves forward, and under the guidance of the front port 211 of the cannula 210 , through the guidance of the sharp end 111 , the locator 100 can pass through the wound and enter the mass tissue smoothly.

In this embodiment, referring to 2-shown in Figure 3, the head 110 is a triangular pyramid structure, and the fixed tail 120 is a metal that extends from the top to the bottom of the pyramid along its ridgeline. The grasping grasp 121 that silk forms.

It can be understood that, in this embodiment, the head 110 of the locator 100 is a triangular pyramid structure, the top of the head 110 of the triangular pyramid structure is the sharp end 111 of the head 110, and the fixed tail 120 of the locator 100 is formed from The triangular pyramid structure head 110 is composed of metal wires with three ridgelines extending backward. In this embodiment, there are also three wires forming the fixed tail 120, and the wires are on the same straight line as the ridge line extending from the head 110 of the triangular pyramid structure in a free state; when the head 110 is placed in the casing 210 , the three metal wires that make up the fixed tail 120 are bound by the sleeve 210 to form a bending state extending along the sleeve 210; Placed in the tumor tissue, and fix the head 110 to the tumor tissue.

It should be noted that the head 110 of the positioner 100 is not limited to a triangular pyramid structure, for example, a quadrangular pyramid, a pentagonal pyramid, etc. are all feasible, and the number of wires fixing the tail 120 can be the same as that of the head 110. It can also be smaller than the number of ridges according to actual needs.

In this embodiment, the head 110 has scratches 130 or rough surfaces that are convenient for development and identification. Specifically, the scratches 130 or rough surfaces are arranged on three sides of the head 110 with a triangular pyramid structure; scratches are set on the head 110 The 130 or rough surface is more convenient for identification by ultrasound imaging equipment or x-ray irradiation.

4-5 show the main technical content of the second embodiment of the present invention. In this embodiment, the pushing device 500 is basically the same as the first embodiment of the present invention, including a sleeve 510 and a push rod 520 .

The structure of the positioner 400 in this embodiment is: the head 410 is a hemispherical structure, the fixed tail 420 is arranged on the bottom surface 411 of the head 410, and the spherical surface of the head 410 faces the front port 511 , the bottom surface 411 of the head 410 faces the rear port 512 .

In this embodiment, the head 410 is a hemispherical structure. When the positioner 400 is placed on the sleeve 510, the top of the head 410 faces the front port 511 of the sleeve 510, and the bottom surface 411 of the head 410 faces the sleeve 510. The rear port 512 , the top of the head 410 refers to the top of the ball of the hemispherical head 410 , and the bottom 411 refers to the bottom 411 of the hemispherical head 410 . When the locator 400 is pushed to the tumor tissue, the top of the head 410 first moves out from the front port 511 of the cannula 510 and enters into the tumor tissue. The effect of the hemispherical structure of the head 410 is that the surface of the hemispherical structure is relatively smooth , is suitable for entering into the wound of tumor tissue, and will not cause discomfort caused by pressing other tissues of the breast on top. In addition, the bottom surface 411 of the hemispherical structure is suitable for placing the fixed tail 420 and facilitating the push of the locator 400 .

In this embodiment, the fixed tail portion 420 is a grasping grip 421 formed by two metal wires, the metal wires include a fixed end connected to the circumference of the bottom surface 411 and a free end, along which the metal wires are fixed. The free end extends outwards and is rolled up, and the free end faces toward the center of the head 410 . The fixed tail part 420 of this structure, its grabbing grip 421 is similar to the finger that is rolled up, and after the locator 400 is placed in the tumor tissue, the grabbing grip 421 will firmly grasp part of the tumor tissue, so that the locator 400 is firmly positioned , will not move, and the positioning will be more precise.

In this embodiment, the head 410 has scratches 430 or rough surfaces that are convenient for development and identification. Specifically, the scratches 430 or rough surfaces are arranged on the hemispherical surface of the head 410 with a hemispherical structure; scratches are set on the head 410 The 430 or rough surface is more convenient for identification by ultrasound imaging equipment or x-ray irradiation.

7-9 show the basic technical content of the third embodiment of the present invention. In this embodiment, the pushing device 800 includes a pushing rod 810, and the pushing rod 810 includes a pushing end 811 and a connecting end 812. The end of the connecting end 812 is provided with an internal thread 8121; the positioner 700 includes a connecting rod 730, and the connecting rod 730 is provided with an external thread 731 matching the internal thread 8121 of the push rod 810; The external thread 731 of the connecting rod 730 can be connected with the internal thread 8121 of the push rod 810 to connect the positioner 700 to the connecting end 812 of the push rod 810; the connecting rod 730 is fixed on the head 710 Or fix the tail 720.

In the positioning device of this embodiment, the internal thread 8121 provided at the end of the connecting end 812 of the push rod 810 is threadedly connected with the external thread 731 of the connecting rod 730 of the locator 700, and the locator 700 is pushed into the tumor tissue, and then along the vertical direction The push rod 810 is rotated in the axial direction, so that the push rod 810 is separated from the locator 700, and the push rod 810 and the locator 700 are taken out and left in the tumor tissue. The effect is that when the locator 700 needs to be taken out, the push rod 810 is inserted into the tumor tissue again, and the internal thread 8121 provided at the end of the connection end 812 of the push rod 810 is connected with the external thread 731 of the connecting rod 730 of the locator 700. Threaded connection, the push rod 810 is connected with the positioner 700, and the positioner 700 is pulled out through the push rod 810.

In this embodiment, the head 710 is a hemispherical structure; the fixed tail 720 is a grab 721 formed by three metal wires, and the grab 721 includes a fixed end connected to a point on the circumference of the bottom surface 711 and a free end, the grabbing grab 721 is arranged so that the free end extends towards the top of the head 710 and the axial distance from the head 710 gradually increases; the connecting rod 730 extends along the head The axial direction of 710 is fixed to the bottom surface 711 of the head 710 .

In the design of the head 710 in this way, the free end of the grabbing grab 721 extends towards the top of the head 710 and the axial distance from the head 710 gradually increases, so that the grabbing grab 721 has a greater force to grab the tumor tissue, and the positioning The device 700 will be placed more stably within the tumor tissue. At the same time, according to the design of the grasping grip 721 , when taking out the positioner 700 , the positioner 700 can be pulled out along the axial direction of the head 710 and the positioner 700 can be easily taken out.

In this embodiment, the head 710 has scratches 740 or rough surfaces that are convenient for development and identification. Specifically, the scratches 740 or rough surfaces are arranged on the hemispherical surface of the head 710 with a hemispherical structure; scratches are set on the head 710 The 740 or rough surface is more convenient for identification by ultrasound imaging equipment or x-ray irradiation.

In the above first to third embodiments, the heads 110, 410, 710 of the positioners 100, 400, 700 are made of titanium alloy materials, and the fixed tails 120, 420, 720 are made of memory metal materials; the fixing parts made of memory metal materials The tail 120, 420, 720 will be deformed when the locator is placed. When placed on the tumor tissue, it will return to its original shape, which is convenient for the locator 100, 400, 700 to be placed on the tumor tissue smoothly and can be placed stably for a long time. produce displacement.

In the description of this specification, descriptions referring to the terms "one embodiment", "some embodiments", "example", "specific examples", or "some examples" mean that specific features described in connection with the embodiment or example , structure, material or feature is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and cannot be construed as limitations to the present invention. Variations, modifications, substitutions, and modifications to the above-described embodiments are possible within the scope of the present invention.

Claims (10)

1. A breast tumor positioning device, characterized in that, comprising: A locator, the locator has a head that can be developed under image guidance and a fixed tail connected to the head that can grab tumor tissue; and A pushing device, the pushing device is used to push the locator to a predetermined position. 2. The breast tumor localization device according to claim 1, wherein the pushing device comprises a sleeve and a push rod, the sleeve comprises a front port and a rear port, and the front port is configured to be relatively The inclined section structure of the axis of the sleeve; the front end of the push rod is arranged in the sleeve in a manner that can move along the axial direction of the sleeve; the locator is placed in the sleeve and can be placed in the sleeve When the push rod moves axially along the casing, it moves out from the front port into the mammary gland mass tissue. 3. The breast tumor localization device according to claim 2, wherein the head has a sharp end and an extension end extending along the sharp end, and the fixed tail is arranged on the extension end; When the locator is placed in the cannula, the sharp end faces the front port, and the extension end faces the rear port. 4. The breast tumor localization device according to claim 3, wherein the head is a pyramid structure, and the fixed tail is that the head of the pyramid extends along its ridge line from the top to the bottom The wires form the grabbing grip. 5. The breast tumor localization device according to claim 2, wherein the head is a hemispherical structure, the fixed tail is arranged on the bottom surface of the head, and the spherical surface of the head faces toward the front port, the bottom surface of the head faces the rear port. 6. The breast tumor localization device according to claim 5, characterized in that, the fixed tail is a grasping grab formed by at least two metal wires, and the metal wire includes a fixed end connected to the circumference of the bottom surface and A free end, the metal wire is extended and rolled outward along its fixed end, and the free end faces the center of the ball of the head. 7. The breast tumor localization device according to claim 1, wherein the pushing device comprises a pushing rod, the pushing rod comprises a pushing end and a connecting end, and the end of the connecting end is provided with an internal thread; The locator includes a connecting rod, and the connecting rod is provided with an external thread adapted to the internal thread of the push rod; the external thread of the connecting rod can be connected with the internal thread of the push rod to position the The device is connected to the connecting end of the push rod; The connecting rod is fixed on the head or the fixed tail. 8. The breast tumor localization device according to claim 7, characterized in that: The head is a hemispherical structure; The fixed tail is a grasping claw formed by at least two metal wires, the grasping grasp includes a fixed end connected to a point on the circumference of the bottom surface and a free end, and the grasping grasp is arranged as the free end Extending toward the top of the head and gradually increasing the axial distance from the head; The connecting rod is fixed on the bottom surface of the head along the axial direction of the head. 9. The breast tumor localization device according to any one of claims 1-8, characterized in that the head has scratches or rough surfaces that are easy to be identified by development. 10. The breast tumor localization device according to any one of claims 1-8, wherein the head is made of titanium alloy material, and the fixed tail is made of memory metal material.