CN106214910A - A kind of medicine treating dysfunctional uterine bleeding and preparation method thereof - Google Patents
A kind of medicine treating dysfunctional uterine bleeding and preparation method thereof Download PDFInfo
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- CN106214910A CN106214910A CN201610701321.3A CN201610701321A CN106214910A CN 106214910 A CN106214910 A CN 106214910A CN 201610701321 A CN201610701321 A CN 201610701321A CN 106214910 A CN106214910 A CN 106214910A
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- 239000003814 drug Substances 0.000 title claims abstract description 38
- 206010027514 Metrorrhagia Diseases 0.000 title claims abstract description 34
- 206010013908 Dysfunctional uterine bleeding Diseases 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 244000211187 Lepidium sativum Species 0.000 claims abstract description 39
- 235000007849 Lepidium sativum Nutrition 0.000 claims abstract description 39
- 239000011324 bead Substances 0.000 claims abstract description 18
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 18
- 108010052008 colla corii asini Proteins 0.000 claims abstract description 15
- 229940056582 human hair preparation Drugs 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 241000213006 Angelica dahurica Species 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 11
- 238000002137 ultrasound extraction Methods 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 229960004756 ethanol Drugs 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000011812 mixed powder Substances 0.000 claims description 6
- 238000005325 percolation Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 3
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 238000009495 sugar coating Methods 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 2
- 238000002386 leaching Methods 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims 5
- 230000000694 effects Effects 0.000 abstract description 6
- 239000000203 mixture Substances 0.000 abstract description 6
- 230000001225 therapeutic effect Effects 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 2
- 210000004369 blood Anatomy 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 239000003755 preservative agent Substances 0.000 abstract description 2
- 230000002335 preservative effect Effects 0.000 abstract description 2
- 210000000952 spleen Anatomy 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 17
- 239000002131 composite material Substances 0.000 description 9
- 230000003203 everyday effect Effects 0.000 description 8
- 230000000740 bleeding effect Effects 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 208000034158 bleeding Diseases 0.000 description 3
- 231100000319 bleeding Toxicity 0.000 description 3
- 230000002513 anti-ovulatory effect Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000016087 ovulation Effects 0.000 description 2
- 230000027758 ovulation cycle Effects 0.000 description 2
- 208000037853 Abnormal uterine bleeding Diseases 0.000 description 1
- 201000005670 Anovulation Diseases 0.000 description 1
- 206010002659 Anovulatory cycle Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 231100000552 anovulation Toxicity 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 238000009802 hysterectomy Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K2236/30—Extraction of the material
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a kind of medicine treating dysfunctional uterine bleeding and preparation method thereof, this medicine is prepared from by the raw material of following weight portion: Radix Angelicae Sinensis 28～32 parts, Radix Rehmanniae Preparata 12～16 parts, Radix Dipsaci 12～16 parts, the Radix Paeoniae Alba 14～18 parts, Rhizoma Dioscoreae 14～18 parts, the Rhizoma Atractylodis Macrocephalae 14～18 parts, charred Radix Sanguisorbae 8～12 parts, the Radix Angelicae Dahuricae 18～22 parts, Concha Ostreae (calcined) 4～8 parts, Endoconcha Sepiae 10～14 parts, Colla Corii Asini bead 3～5 parts, Crinis Carbonisatus 12～14 parts, Lepidium sativum L. extract 8～12 parts.The medicine of the treatment dysfunctional uterine bleeding that the present invention provides, is prepared from natural Chinese medicinal herb for raw material, without adding preservative and western medicine composition, has spleen invigorating of enriching blood, admittedly through multiple efficacies such as leukorrhagia stopping；The medicine that the present invention provides, each component compatibility is proper, and synergy is notable, good to dysfunctional uterine bleeding therapeutic effect, instant effect, and safety has no side effect.
Description
Technical field
The invention belongs to tcm field, be specifically related to a kind of medicine treating dysfunctional uterine bleeding and preparation thereof
Method.
Background technology
Dysfunctional uterine bleeding is the abnormal uterine bleeding caused due to reproductive endocrine s function disorder, is a kind of
Common gynaecopathia.The pathogenic factors of dysfunctional uterine bleeding mainly includes direct stimulation, overworked, nutrition not
Good, metabolism disorder, chronic disease, environment change etc..Dysfunctional uterine bleeding main Types include anovulatory functional bleeding and
There is ovulation type anovulatory dysfunctional uterine hemorrhage.Anovulation type dysfunctional uterine bleeding is apt to occur in adolescence and Menopausal transitional period, on patient clinical
Common symptom is metrorrhagia, shows as the confusion of the menstrual cycle, menstrual period different in size, indefinite through amount or increase, very
To bleeding profusely, i.e. the traditional Chinese medical science is so-called " metrorrhagia ".Ovulation type dysfunctional uterine bleeding normally behaves as menstrual cycle rule, warp
Phase is normal, but menorrhagia.Serious dysfunctional uterine bleeding is likely to result in anemia, secondary infection, sterile, even leads
Cause hysterectomy.
Dysfunctional uterine bleeding takes Western medicine, hormone therapy the most mostly, for patient's row that amount of bleeding is many
Dilatation and curettage of uterine is treated, and Western medicine side effect is big, and therapeutic effect is unsatisfactory, and patient's body and mind can be caused and have a strong impact on, far by dilatation and curettage of uterine treatment
Phase weak curative effect.
Summary of the invention
The present invention is primarily directed to the problem that existing method treatment dysfunctional uterine bleeding effect is bad, it is provided that a kind of
The medicine for the treatment of dysfunctional uterine bleeding, present invention also offers the preparation method of this medicine simultaneously.
The medicine of the treatment dysfunctional uterine bleeding that the present invention provides, is prepared from by the raw material of following weight portion:
Radix Angelicae Sinensis 28～32 parts, Radix Rehmanniae Preparata 12～16 parts, Radix Dipsaci 12～16 parts, the Radix Paeoniae Alba 14～18 parts, Rhizoma Dioscoreae 14～18 parts, the Rhizoma Atractylodis Macrocephalae 14～18
Part, charred Radix Sanguisorbae 8～12 parts, the Radix Angelicae Dahuricae 18～22 parts, Concha Ostreae (calcined) 4～8 parts, Endoconcha Sepiae 10～14 parts, Colla Corii Asini bead 3～5 parts, Crinis Carbonisatus
12～14 parts, Lepidium sativum L. extract 8～12 parts.
Theory of Chinese medical science is thought, the basic pathogenesis of dysfunctional uterine bleeding is owing to punching appoints loss caused, applicant's root
According to theory of Chinese medical science, for the pathogeny of dysfunctional uterine bleeding, on the basis of existing technology, send out through great many of experiments
Existing, by Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Radix Dipsaci, the Radix Paeoniae Alba, Rhizoma Dioscoreae, the Rhizoma Atractylodis Macrocephalae, charred Radix Sanguisorbae, the Radix Angelicae Dahuricae, Concha Ostreae (calcined), Endoconcha Sepiae, Colla Corii Asini bead, Crinis Carbonisatus
Carrying out suitable compatibility with Lepidium sativum L. extract, after compatibility, the treatment of dysfunctional uterine bleeding is had significantly by the medicine of preparation
Clinical effectiveness.
As preferably, the medicine of described treatment dysfunctional uterine bleeding, the raw material of following weight portion it is prepared from:
Radix Angelicae Sinensis 30 parts, Radix Rehmanniae Preparata 14 parts, Radix Dipsaci 14 parts, the Radix Paeoniae Alba 16 parts, Rhizoma Dioscoreae 16 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, charred Radix Sanguisorbae 10 parts, the Radix Angelicae Dahuricae 20 parts,
Concha Ostreae (calcined) 6 parts, Endoconcha Sepiae 12 parts, Colla Corii Asini bead 4 parts, Crinis Carbonisatus 13 parts, Lepidium sativum L. extract 10 parts.
As preferably, the extracting method of described Lepidium sativum L. extract is as follows:
(1) smash to pieces after fresh for Lepidium sativum L. leaf being cleaned, obtain Lepidium sativum L. serosity；
(2) Lepidium sativum L. serosity is mixed homogeneously by solid-liquid ratio 28～30g/L with dehydrated alcohol, use ultrasonic extraction to carry
Take liquid；
(3) being filtered by extracting solution, filtrate i.e. obtains Lepidium sativum L. extract through being concentrated in vacuo, after lyophilization.
As preferably, in above-mentioned steps (2), the temperature of ultrasonic extraction is 65～70 DEG C.
As preferably, in above-mentioned steps (2), the time of ultrasonic extraction is 30～40min.
As preferably, in above-mentioned steps (2), the power of ultrasonic extraction is 500～700W.
The present invention uses ultrasonic extraction Lepidium sativum L., can be effectively improved the extraction ratio of effective ingredient in Lepidium sativum L., above-mentioned
In Lepidium sativum L. extraction conditions, temperature controls particularly important, Lepidium sativum L. extract and other groups of all affecting too high or too low for temperature
The effect divided.
Present invention also offers the preparation method treating dysfunctional uterine bleeding medicine as above, step is such as
Under:
(1), after the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae half and half amount and Crinis Carbonisatus being mixed, pulverized 200 mesh sieves and obtained mixed-powder；
(2) Radix Angelicae Sinensis, the Radix Angelicae Dahuricae being pulverized 80 mesh sieves respectively, and obtained Chinese Angelica Root, Dahurian Angelica Root, Chinese Angelica Root is by 6 times of quality
70% ethanol carry out percolation, Dahurian Angelica Root carries out percolation with 60% ethanol of 6 times of quality, collects liquid of filtering, is respectively prepared Radix Angelicae Sinensis
Extractum, Radix Angelicae Dahuricae extractum；
(3) by Radix Rehmanniae Preparata, Radix Dipsaci, charred Radix Sanguisorbae, Concha Ostreae (calcined), Endoconcha Sepiae and the remaining Radix Paeoniae Alba, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae mixing, add
The soak by water 3h of 8 times of quality of mixture, filters and collects filtrate, and filtering residue with the soak by water 2h of 6 times of quality, filters and collects filter again
Liquid, is combined and concentrated to the thick paste that relative density is 1.25 by filtrate；
(4) in the thick paste of step (3), add Colla Corii Asini bead, after Colla Corii Asini bead dissolves, add Lepidium sativum L. extract and step
(1) mixed-powder, is dried after mixing, pulverizes, and the component after pulverizing adds the eumenol of step (2), Radix Angelicae Dahuricae extractum, mixing
The medicine for the treatment of dysfunctional uterine bleeding is i.e. obtained by granulation, tabletted, sugar coating.
The invention has the beneficial effects as follows: the medicine of the treatment dysfunctional uterine bleeding that the present invention provides, in natural
Medical herbs is that raw material is prepared from, and without adding preservative and western medicine composition, has spleen invigorating of enriching blood, admittedly through multiple efficacies such as leukorrhagia stopping；This
The medicine that invention provides, each component compatibility is proper, and synergy is notable, good to dysfunctional uterine bleeding therapeutic effect, sees
Effect is fast, and safety has no side effect.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme is described further.
If not raw material of the present invention and equipment refer in particular to, all it is commercially available or commonly used in the art, implements
Method in example, if no special instructions, is the conventional method of this area.
Embodiment 1
The medicine treating dysfunctional uterine bleeding in the present embodiment is prepared from the following materials: Radix Angelicae Sinensis 30g, Radix Rehmanniae Preparata
Yellow 14g, Radix Dipsaci 14g, Radix Paeoniae Alba 16g, Rhizoma Dioscoreae 16g, Rhizoma Atractylodis Macrocephalae 16g, charred Radix Sanguisorbae 10g, Radix Angelicae Dahuricae 20g, Concha Ostreae (calcined) 6g, Endoconcha Sepiae 12g, Ah
Glue bead 4g, Crinis Carbonisatus 13g, Lepidium sativum L. extract 10g.
Preparation method is: after the 8g Radix Paeoniae Alba, the 8g Rhizoma Atractylodis Macrocephalae, 8g Rhizoma Dioscoreae and 13g Crinis Carbonisatus are mixed by (1), pulverized 200 mesh sieves and obtains
Mixed-powder；
(2) 30g Radix Angelicae Sinensis, the 20g Radix Angelicae Dahuricae being pulverized 80 mesh sieves respectively, and obtained Chinese Angelica Root, Dahurian Angelica Root, Chinese Angelica Root is with 6
70% ethanol of times quality carries out percolation, and Dahurian Angelica Root 60% ethanol of 6 times of quality carries out percolation, collects liquid of filtering, makes respectively
Become eumenol, Radix Angelicae Dahuricae extractum；
(3) by 14g Radix Rehmanniae Preparata, 14g Radix Dipsaci, 10g charred Radix Sanguisorbae, 6g Concha Ostreae (calcined), 12g Endoconcha Sepiae and the remaining 8g Radix Paeoniae Alba, 8g
Rhizoma Dioscoreae, the mixing of the 8g Rhizoma Atractylodis Macrocephalae, add the soak by water 3h of mixture quality 8 times, filter and collect filtrate, and filtering residue is again by 6 times of quality
Soak by water 2h, filters and collects filtrate, in 60 DEG C, filtrate is rotated forwarding and is concentrated into the thick paste that relative density is 1.25；
(4) in the thick paste of step (3) add 4g Colla Corii Asini bead, after Colla Corii Asini bead dissolves, add 10g Lepidium sativum L. extract and
The mixed-powder of step (1), is dried after mixing, pulverizes, and the component after pulverizing adds the eumenol of step (2), Radix Angelicae Dahuricae leaching
Cream, i.e. obtains the medicine for the treatment of dysfunctional uterine bleeding through granulation, tabletted, sugar coating after mixing.
Wherein, the extracting method of Lepidium sativum L. extract is:
(1) smash to pieces after fresh for Lepidium sativum L. leaf disinfectant solution being cleaned, obtain Lepidium sativum L. serosity；
(2) Lepidium sativum L. serosity is mixed homogeneously by solid-liquid ratio 28g/L with dehydrated alcohol, use ultrasonic extraction to extract
Liquid, extraction conditions is: temperature 68 DEG C, time 35min, and power is 600W；
(3) being filtered by extracting solution, filtrate is after 30 DEG C of rotated evaporimeters are concentrated in vacuo, then by concentrated solution lyophilization is
Obtain Lepidium sativum L. extract.
Embodiment 2
The medicine treating dysfunctional uterine bleeding in the present embodiment is prepared from the following materials: Radix Angelicae Sinensis 28g, Radix Rehmanniae Preparata
Yellow 12g, Radix Dipsaci 12g, Radix Paeoniae Alba 14g, Rhizoma Dioscoreae 14g, Rhizoma Atractylodis Macrocephalae 14g, charred Radix Sanguisorbae 8g, Radix Angelicae Dahuricae 18g, Concha Ostreae (calcined) 4g, Endoconcha Sepiae 10g, Ah
Glue bead 3g, Crinis Carbonisatus 12g, Lepidium sativum L. extract 8g.
Wherein, preparation method is identical with embodiment 1；In the extracting method of Lepidium sativum L. extract, Extracting temperature is 65 DEG C, carries
The time of taking is 30min, and ultrasonic power is 500W, and other are identical with embodiment 1.
Embodiment 3
The medicine treating dysfunctional uterine bleeding in the present embodiment is prepared from the following materials: Radix Angelicae Sinensis 32g, Radix Rehmanniae Preparata
Yellow 16g, Radix Dipsaci 16g, the Radix Paeoniae Alba 18, Rhizoma Dioscoreae 18g, Rhizoma Atractylodis Macrocephalae 18g, charred Radix Sanguisorbae 12g, Radix Angelicae Dahuricae 22g, Concha Ostreae (calcined) 8g, Endoconcha Sepiae 14g, Ah
Glue bead 5g, Crinis Carbonisatus 14g, Lepidium sativum L. extract 12g.
Wherein, preparation method is identical with embodiment 1；In the extracting method of Lepidium sativum L. extract, Extracting temperature is 70 DEG C, carries
The time of taking is 40min, and ultrasonic power is 700W, and other are identical with embodiment 1.
Comparative example 1
In this comparative example, herbal composite is prepared from the following materials: Radix Angelicae Sinensis 30g, Radix Rehmanniae Preparata 14g, Radix Dipsaci 14g,
Radix Paeoniae Alba 16g, Rhizoma Dioscoreae 16g, Rhizoma Atractylodis Macrocephalae 16g, charred Radix Sanguisorbae 10g, Radix Angelicae Dahuricae 20g, Concha Ostreae (calcined) 6g, Endoconcha Sepiae 12g, Colla Corii Asini bead 4g, Crinis Carbonisatus
13g.The preparation method of this herbal composite is identical with the process for preparing medicine in embodiment 1, and difference is without walking alone
Dish extract.
Comparative example 2～5
In comparative example 2, comparative example 3, comparative example 4 and comparative example 5, its herbal composite is by the preparation of following raw material
Become: Radix Angelicae Sinensis 30g, Radix Rehmanniae Preparata 14g, Radix Dipsaci 14g, Radix Paeoniae Alba 16g, Rhizoma Dioscoreae 16g, Rhizoma Atractylodis Macrocephalae 16g, charred Radix Sanguisorbae 10g, Radix Angelicae Dahuricae 20g, Concha Ostreae (calcined)
6g, Endoconcha Sepiae 12g, Colla Corii Asini bead 4g, Crinis Carbonisatus 13g, Lepidium sativum L. extract 10g.
Wherein, the herbal composite in comparative example 2～5, its preparation method all with the process for preparing medicine in embodiment 1
Identical, difference is the extraction conditions of Lepidium sativum L. extract, in comparative example 2, comparative example 3, comparative example 4 and comparative example 5, solely
The Extracting temperature of row dish extract is respectively 50 DEG C, 60 DEG C, 75 DEG C, 80 DEG C, and other conditions are identical.
Clinical experiment
One, clinical case
The 400 example patients with dysfunctional uterine bleedings through making a definite diagnosis, the course of disease 1～12 months, the age between 20～45 years old,
400 patients are randomly divided into 8 groups, often organize 50 people: treatment group 1, treatment group 2, treatment group 3, matched group 1, matched group 2, comparison
Group 3, matched group 4 and matched group 5, respectively organize the influence factors such as the age of patient, the state of an illness, without significant difference, meet packet condition.
Two, Therapeutic Method
Treatment group 1 gives the medicine of embodiment 1 preparation, and morning, noon and afternoon every day are each once, each 2, oral, every 0.4g；
Treatment group 2 gives the medicine of embodiment 2 preparation, and morning, noon and afternoon every day are each once, each 2, oral, every 0.4g；
Treatment group 3 gives the medicine of embodiment 3 preparation, and morning, noon and afternoon every day are each once, each 2, oral, every 0.4g；
Matched group 1 gives the herbal composite of comparative example 1 preparation, and morning, noon and afternoon every day are each once, each 2, oral, often
Sheet 0.4g；
Matched group 2 gives the herbal composite of comparative example 2 preparation, and morning, noon and afternoon every day are each once, each 2, oral, often
Sheet 0.4g；
Matched group 3 gives the herbal composite of comparative example 3 preparation, and morning, noon and afternoon every day are each once, each 2, oral, often
Sheet 0.4g；
Matched group 4 gives the herbal composite of comparative example 4 preparation, and morning, noon and afternoon every day are each once, each 2, oral, often
Sheet 0.4g；
Matched group 5 gives the herbal composite of comparative example 5 preparation, and morning, noon and afternoon every day are each once, each 2, oral, often
Sheet 0.4g.
Three, efficacy assessment standard
Effective: to stop blooding in treating 10 days, continue to observe 7 days be effective without bleeder；
Effective: to stop blooding in treating 15 days, continue to observe 7 days be effective without bleeder；
Invalid: to treat and do not stop blooding as invalid for 15 days.
Four, therapeutic effect
Therapeutic effect statistical result respectively organized by table 1
From data in table, treatment group 1, treatment group 2, treatment group 3 are being taken embodiment 1, embodiment 2 respectively, are being implemented
The medicine that example 3 provides is treated, and in 15 days, total effective rate is more than 94%, and the total effective rate of matched group 1 only has 72%, bright
Aobvious less than treatment group, illustrate Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Radix Dipsaci, the Radix Paeoniae Alba, Rhizoma Dioscoreae, the Rhizoma Atractylodis Macrocephalae, charred Radix Sanguisorbae, the Radix Angelicae Dahuricae, Concha Ostreae (calcined), Endoconcha Sepiae,
The mixture of Colla Corii Asini bead and Crinis Carbonisatus adds appropriate Lepidium sativum L. extract, is remarkably improved said mixture treatment function and loses
The effect of tonality metrorrhagia；And the total effective rate of matched group 2, matched group 3, matched group 4 and matched group 5 only 36～40% it
Between, when ultrasonic extraction Lepidium sativum L. is described, the Lepidium sativum L. extract impact that temperature controls extracting is very big, only at 65～70 DEG C
Time extract Lepidium sativum L. extract be just applicable to the present invention.
Claims (7)
1. the medicine treating dysfunctional uterine bleeding, it is characterised in that be prepared from by the raw material of following weight portion:
Radix Angelicae Sinensis 28～32 parts, Radix Rehmanniae Preparata 12～16 parts, Radix Dipsaci 12～16 parts, the Radix Paeoniae Alba 14～18 parts, Rhizoma Dioscoreae 14～18 parts, the Rhizoma Atractylodis Macrocephalae 14～18
Part, charred Radix Sanguisorbae 8～12 parts, the Radix Angelicae Dahuricae 18～22 parts, Concha Ostreae (calcined) 4～8 parts, Endoconcha Sepiae 10～14 parts, Colla Corii Asini bead 3～5 parts, Crinis Carbonisatus
12～14 parts, Lepidium sativum L. extract 8～12 parts.
Medicine the most according to claim 1, it is characterised in that be prepared from by the raw material of following weight portion: Radix Angelicae Sinensis 30 parts,
Radix Rehmanniae Preparata 14 parts, Radix Dipsaci 14 parts, the Radix Paeoniae Alba 16 parts, Rhizoma Dioscoreae 16 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, charred Radix Sanguisorbae 10 parts, the Radix Angelicae Dahuricae 20 parts, Concha Ostreae (calcined) 6 parts,
Endoconcha Sepiae 12 parts, Colla Corii Asini bead 4 parts, Crinis Carbonisatus 13 parts, Lepidium sativum L. extract 10 parts.
Medicine the most according to claim 1 and 2, it is characterised in that the extracting method of described Lepidium sativum L. extract is as follows:
(1) smash to pieces after fresh for Lepidium sativum L. leaf being cleaned, obtain Lepidium sativum L. serosity；
(2) Lepidium sativum L. serosity is mixed homogeneously by solid-liquid ratio 28～30g/L with dehydrated alcohol, use ultrasonic extraction to extract
Liquid；
(3) being filtered by extracting solution, filtrate i.e. obtains Lepidium sativum L. extract through being concentrated in vacuo, after lyophilization.
Medicine the most according to claim 3, it is characterised in that in step (2), the temperature of ultrasonic extraction is 65～70 DEG C.
Medicine the most according to claim 4, it is characterised in that in step (2) time of ultrasonic extraction be 30～
40min。
Medicine the most according to claim 5, it is characterised in that in step (2) power of ultrasonic extraction be 500～
700W。
7. the preparation method of medicine as described in any one of claim 1 to 6, it is characterised in that step is as follows:
(1), after the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae half and half amount and Crinis Carbonisatus being mixed, pulverized 200 mesh sieves and obtained mixed-powder；
(2) Radix Angelicae Sinensis, the Radix Angelicae Dahuricae being pulverized 80 mesh sieves respectively, and obtained Chinese Angelica Root, Dahurian Angelica Root, Chinese Angelica Root is by 6 times of quality
70% ethanol carries out percolation, and Dahurian Angelica Root 60% ethanol of 6 times of quality carries out percolation, collects liquid of filtering, and is respectively prepared Radix Angelicae Sinensis leaching
Cream, Radix Angelicae Dahuricae extractum；
(3) by Radix Rehmanniae Preparata, Radix Dipsaci, charred Radix Sanguisorbae, Concha Ostreae (calcined), Endoconcha Sepiae and the remaining Radix Paeoniae Alba, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae mixing, mixing is added
The soak by water 3h of 8 times of quality of thing, filters and collects filtrate, and filtering residue with the soak by water 2h of 6 times of quality, filters and collects filtrate again,
Filtrate is combined and concentrated to the thick paste that relative density is 1.25；
(4) in the thick paste of step (3), add Colla Corii Asini bead, after Colla Corii Asini bead dissolves, add Lepidium sativum L. extract and step (1)
Mixed-powder, is dried after mixing, pulverizes, and the component after pulverizing adds the eumenol of step (2), Radix Angelicae Dahuricae extractum, warp after mixing
Granulation, tabletted, sugar coating i.e. obtain the medicine for the treatment of dysfunctional uterine bleeding.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215048A (en) * | 2016-08-22 | 2016-12-14 | 常德永利盛祥生物科技有限公司 | A kind of Chinese medicine composition treating hemorrhoid and preparation method thereof |
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| CN1480173A (en) * | 2002-12-06 | 2004-03-10 | 长沙市泰宝制药有限公司 | Chinese herbal medicine for treating gynecology disease and its preparing method |
| CN1830477A (en) * | 2005-03-07 | 2006-09-13 | 湖南德海制药有限公司 | Medicine for treating woman deficiency of blood gynecological and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106215048A (en) * | 2016-08-22 | 2016-12-14 | 常德永利盛祥生物科技有限公司 | A kind of Chinese medicine composition treating hemorrhoid and preparation method thereof |
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