CN106214289A - A kind of heart volume reduction implant - Google Patents
A kind of heart volume reduction implant Download PDFInfo
- Publication number
- CN106214289A CN106214289A CN201610805723.8A CN201610805723A CN106214289A CN 106214289 A CN106214289 A CN 106214289A CN 201610805723 A CN201610805723 A CN 201610805723A CN 106214289 A CN106214289 A CN 106214289A
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- Prior art keywords
- dropbox
- volume reduction
- heart
- implant
- heart volume
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2478—Passive devices for improving the function of the heart muscle, i.e. devices for reshaping the external surface of the heart, e.g. bags, strips or bands
- A61F2/2487—Devices within the heart chamber, e.g. splints
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0093—Umbrella-shaped, e.g. mushroom-shaped
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- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a kind of heart volume reduction implant, including the choked flow film in contractile Dropbox and Dropbox, and be connected and be positioned at the fixed disk of described Dropbox one end with described Dropbox, described Dropbox is bowl-shape；This heart volume reduction implant is for the feature of Minimally Interventional Therapy and needs, especially by Dropbox and the optimization of fixed disk structure, improve the contractility of Dropbox, heart volume reduction implant is conducive to be loaded in induction system, thus the diameter of delivery conduit can be reduced, reduce the implantation process damage to blood vessel tissue.Utilizing the super-elasticity of implant, implantation process is not required to use the mode of balloon expandable again, and additionally this implant has the function of repeatable positioning action, and operation technique is convenient and simple.This implant utilizes that fixed disk is unsettled is fixed on core indoor wall, will not contact with the apex of the heart, it is to avoid the infringement to patient's apex of the heart of the heart volume reduction implant.
Description
Technical field
The present invention relates to operation on heart technique with the apparatus field, particularly a kind of heart volume reduction implant.
Background technology
In clinical treatment now, the hyperemia being characterized with plumpness or the expansion of heart (such as Fig. 1) particularly left ventricle
DHF (Congestive Heart Failure, CHF) is dead and disabled main cause.The heart along with patient
Room enlargement, the efficiency of heart pump blood is more and more lower, little by little, heart become more enlargement and such that it does not supply to health
Blood that should be enough.Medically using ejection fraction to pass judgment on the heart of patient the most healthy, ejection fraction refers to intraventricular
Blood is the ability of outwards pumping at each second.The snake blood mark of the heart that normal person is healthy is about 60%, and CHF patient
It is the least that ejection fraction generally only has 40%.CHF patient has regular fatigue, physical disabilities and bears pain and discomfort
Disease, more seriously along with the enlargement of ventricle, cardiac valve pullled deformation and cannot be fully closed, the two of incompetence
Cusp can cause blood to be back to left atrium from left ventricle, further have impact on the pump blood ability of heart, causes health status
Deterioration.There is the factor of CHF much in patient, causes including virus infection, cardiac valve incompetence, heart wall ischemic etc.
Formed.Long-time ischemia coronarius and block that to may result in the cardiac muscular tissue in ventricle wall dying and become scar tissue.One
A part for denier cardiac muscular tissue is dead, then this part just no longer contributes to the pump action of heart.Along with the development of the state of an illness, impaired
The regional area of cardiac muscle can swell during heart contraction, reduces the pump blood ability of heart further, and blood is penetrated in reduction further
Mark.
For in the treatment means of CHF, pharmacotherapy is the most the most frequently used conventional therapy, but pharmacotherapy can not
Cure diseases, can only slow down the symptom of disease.And in surgical operation, heart transplant operation risk is high, big to patient trauma, operation
Somewhat expensive, and donor hearts eligibility criteria requires the too high heart shortage causing and being available for transplanting.Surgery ventricular remodeling is performed the operation
Closing ventricular aneurysm by open chest surgery, reach to reduce ventricular volume with this, reduce idioventricular pump blood ability, earlier results shows
Showing and have good prospects, but wound is big, effect is not ideal enough, and this technology also exists dispute the most always.
In recent years, Minimally Interventional Therapy method starts to get the nod, and with reference to Fig. 2, specifically uses " the fall that a kind of percutaneous is got involved
Fall umbrella ", " parachute " typically should be made up of isolation layer and base, get involved after left ventricle sets up passage (such as Fig. 3 institute through delivery conduit
Show), " parachute " can be implanted left ventricle target position.By recession delivery conduit, " parachute " can be carried out release operation (such as figure
Shown in 4), after base discharges completely, it is ensured that base is covered on the apex of the heart of left ventricle.After " parachute " discharges completely, for
Guarantee that isolation layer is covered on the locular wall of left ventricle, with sacculus, the isolation layer of " parachute " fully need to be expanded.Drop back defeated
Sending conduit and sacculus, " parachute " has discharged (as shown in Figure 6), and left ventricle can be divided into two-layer by " parachute ", thus reaches
Isolation ventricular aneurysm, reduces ventricular volume, the therapeutic purposes of reduction ventricular pump blood ability.Such as Patent No. 201420564242.9
" a kind of implant loading system ", just describe funnel device for expandable implant being loaded onto in guiding catheter, with
For delivery to ventricle to treat heart failure, implant loading system includes funnel device, has flaring first end and
Two ends, and sleeve is removably coupled to the second end of described funnel device, wherein said sleeve be configured as by described can
Expansion implant is sent to guiding catheter.The most such as Patent No. 201420118276.5 " a kind of for polymer sheet is solid
Surely the assembling fixture of the rib part of frame structure is arrived ", mention, by delivery system, partition member is delivered to the ventricle of patient also
Partition member is launched to separate ventricle as shown in Figure 6, when partition member launches in ventricle, by fill port by filled stream
Body is filled into the first chamber of the interior axle of delivery catheter, and fluid is filled with balloon interior by delivery catheter, so that balloon expandable.Expansion
Sacculus compress partition member partition member is fully expanded, to ensure that the pointed tip of partition member near-end is pressed into fully
The tissue of ventricle.A designer devises a kind of left ventricle capacity-reduction device the most again, specifically can refer to Patent No.
" the left ventricle capacity-reduction device " of 201510042170.0, it is mentioned that base and the two-piece design of main body, base shape is cage
Shape structure, main body uses Nitinol pipe entirety cut molding, and the design in multi-layer net, and grid is closed loop knot
Structure designs, and the top of main body is additionally provided with the anchor thorn tilted upward, and base is woven into woven mesh structure by titanium-nickel wire, at heat
Manage discoid.
But above-mentioned this kind of " parachute " and implantation thereof have the disadvantage that 1, existing " parachute " product
Supporting base uses macromolecular material to be made, and after base is compressed, diameter is the biggest, causes outside required delivery conduit
Footpath 14Fr to be exceeded, therefore, being implanted by delivery conduit can major injury blood vessel in the operative process of " parachute "
Tissue；2, existing " parachute " base elasticity is not enough, it is impossible to play the effect of regulation parachute product height, therefore in release
In operative process, base to be ensured is covered in the apex of the heart position of ventricle completely, requires high, directly to operator's technology
Connect the popularization of influence technique；3, the not reproducible positioning action of existing " parachute " product, if off-position is improper, it is impossible to carry out
Withdrawing of parachute, i.e. can not realize the resetting of product；4, the art formula of existing implantation " parachute ", discharges at isolation layer
After, need to use balloon expandable isolation layer, necessarily increase the operating time of operation；5, after the release of existing " parachute " product,
Supporting base to need to be permanently connected to apex of the heart inwall, in heart ceaselessly beat process, apex of the heart inwall is inevitably subject to
To the friction of support base, so that causing the damage to patient's apex of the heart.
Summary of the invention
In order to overcome the deficiencies in the prior art, the present invention provides a kind of heart volume reduction implant.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of heart volume reduction implant, connects including the choked flow film in contractile Dropbox and described Dropbox and with described Dropbox
Connecing and be positioned at the fixed disk of described Dropbox one end, described Dropbox is bowl-shape.
As a preference, by telescopic joint between described Dropbox and fixed disk.
As a preference, described Dropbox is by nitinol alloy wire or or the B alloy wire braiding webmaster such as cochrome silk
Compressing.
As a preference, described fixed disk uses Nitinol or cochrome to make.
As a preference, at least one anchor thorn is set near the end of described fixed disk.
As a preference, described fixed disk and sleeve pipe are formed in one.
As a preference, the material of described sleeve pipe is rustless steel or Nitinol.
As a preference, one end of described Dropbox is provided with adapter sleeve.
As a preference, described choked flow film is the politef being coated on the inside and outside wall of Dropbox after heat seal processes
Thin film.
As a preference, described choked flow film is the mylar being coated on Dropbox inwall after sutured process.
The invention has the beneficial effects as follows: this heart volume reduction implant, for the feature of Minimally Interventional Therapy and needs, passes through
Reasonably structural improvement, especially by Dropbox and the optimization of fixed disk structure, improves the contractility of Dropbox, the beneficially heart
Dirty volume reduction implant is loaded in induction system, thus can reduce the diameter of delivery conduit, reduces implantation process to blood vessel
The damage of tissue, reaches more preferable therapeutic effect.The heart volume reduction implant of the present invention uses shape to prepare by memory metal, releases
Heart volume reduction implant can be fixed in ventricle by shape mnemonic securely that utilize fixed disk self after putting, additionally Dropbox
The super-elasticity of self, also can completely open after release and be fitted in core indoor wall, from without using the mode of balloon expandable again, and hands
Art is easy to operate simply, can shorten whole operation time, improves the safety that heart volume reduction implant is got involved.This
The Dropbox of bright heart volume reduction implant is provided with adapter sleeve, can realize the controllable release with conveyer device by adapter sleeve and operate,
There is the function of repeatable positioning action, the most at that time at placement location can again regain implant by adapter sleeve and again determine
Position and release.The heart volume reduction implant of the present invention utilizes that fixed disk is unsettled is fixed on core indoor wall, will not connect with the apex of the heart
Touch, it is to avoid the heart volume reduction implant infringement to patient's apex of the heart.
Accompanying drawing explanation
The present invention is further described with embodiment below in conjunction with the accompanying drawings.
Fig. 1 is prior art products structural representation.
Fig. 2 is prior art products conveying and the operating diagram of release.
Fig. 3 is the operating diagram of prior art balloon expandable product.
Fig. 4 is the operating diagram of prior art products.
Fig. 5 is the product structure schematic diagram of the present invention.
Fig. 6 is present invention feed status schematic diagram in delivery conduit.
Fig. 7 is the operating diagram of the present invention.
Fig. 8 is the welding production schematic diagram of the present invention.
Fig. 9 is the choked flow film production schematic diagram of the present invention.
Figure 10 is the choked flow film production schematic diagram of another embodiment of the present invention.
Detailed description of the invention
In order to make the purpose of the application, technical scheme and advantage clearer, below in conjunction with drawings and Examples, right
The present invention is further elaborated.For the thorough explanation present invention, following description can relate to some certain detail
Joint.And when not having these specific detail, the present invention then may still can realize, i.e. technical staff in art uses herein
These describe and statement others skilled in the art in art effectively introduce their work essence.In addition need
Bright, the word " upper end " used in describing below and " lower section " etc. refer to the direction in accompanying drawing, word " inner side " and " outward
Side " refer respectively to the direction towards or away from particular elements geometric center, term " far-end " and " near-end " belong to medical apparatus and instruments
The common terminology in field, " far-end " represents the one end in operation process away from operator, and " near-end " represents close in operation process
One end of operator, person skilled should not be construed as this Shen in the adjustment that above-mentioned direction is made simply, be need not creativeness
Please technology beyond protection domain.Should be appreciated that specific embodiment described herein, and need not only in order to explain the application
In limiting real protection scope.And for avoiding confusion the purpose of the present invention, owing to the technology such as the manufacture method known are held the most very much
Readily understood, therefore they are not described in detail.
With reference to Fig. 5, a kind of heart volume reduction implant 1, including the choked flow film 3 in contractile Dropbox 2 and described Dropbox 2,
And it being connected and is positioned at the fixed disk 4 of described Dropbox 2 one end with described Dropbox 2, described Dropbox 2 is in bowl-shape.Wherein said Dropbox 2
With described fixed disk 4 as the main body of heart volume reduction implant 1, can be by the shape memory function that has often used in the industry
Material is made, and the most described Dropbox 2 requires have enough compressibilityes and elasticity, and the other end of described Dropbox is provided with adapter sleeve 5,
The other end of described fixed disk is provided with anchor thorn 6.
During specific works, heart volume reduction implant needs conveyer device to assist, and wherein conveyer device includes delivery conduit, expansion
Prop, protection conduit and propelling movement wirerope.One end of described Dropbox 2 is provided with adapter sleeve 5, and described adapter sleeve 5 can be joined with conveyer device
Close, for conveying or the release of described heart volume reduction implant.For the safe ready operated, this adapter sleeve 5 is controllable release
Parts.For example, referring to Fig. 6, this adapter sleeve 5 is helicitic texture, can be connected with pushing wirerope 601, certainly, and this adapter sleeve 5
Can also be the controllable release parts of other equivalence, such as magnetic connector, Elastic buckle, Carcel etc..Can be real by adapter sleeve 5
Now the controllable release with conveyer device operates, it is achieved the repeatable positioning action of heart volume reduction implant 1, thus increases heart and subtract
Hold implant 1 and get involved the safety of operative process.Heart volume reduction implant 1 is detachably connected to push away by adapter sleeve 5
Send the far-end of wirerope 601, by pushing wirerope 601, heart volume reduction implant 1 is loaded in the tube chamber of delivery conduit 201, profit
By the super-elasticity of heart volume reduction body 1, heart volume reduction implant 1 becomes feed status after delivery conduit 201 limits, in order to heart
Volume reduction implant 1 carries in the tube chamber of delivery conduit 201.
The seal wire using the industry conventional establishes path after puncturing, and be will be loaded with the delivery conduit of dilator by seal wire
Import target position.Then withdrawing from dilator, the protection conduit that will be loaded with heart volume reduction implant imports target position by delivery conduit.
Heart volume reduction implant 1 discharges after the target position that delivery conduit 201 is transported to left ventricle, by heart volume reduction implant 1
Anchor thorn 6 penetrate in the locular walls 701 of left ventricle, heart volume reduction implant 1 can be made to be fixed on vacantly in left ventricle, as
Shown in Fig. 7.Left ventricle can be divided into function part 401 and isolation part 402 two parts by now heart volume reduction implant 1, thus reaches
Isolation ventricular aneurysm, reduces left ventricular volume, the therapeutic purposes of reduction left ventricle pump blood ability.
Further embodiment, with reference to a kind of heart volume reduction implant of Fig. 5, Fig. 8, " embodiment " the most referred to herein is
Refer to may be included in special characteristic, structure or the characteristic at least one implementation of the application.Different in this manual local
" in the embodiment " that occur not refers both to same embodiment, is not single or optionally arranges mutually with other embodiments
The embodiment scolded.Embodiment includes the choked flow film 3 in contractile Dropbox 2 and described Dropbox 2, and is connected with described Dropbox 2
And it being positioned at the fixed disk 4 of described Dropbox 2 one end, described Dropbox 2 is in bowl-shape.By set between described fixed disk 2 and described Dropbox 2
Pipe 7 connects, and specifically the far-end 51 of adapter sleeve 5 can pass through the bonding machine such as argon arc welding or laser welding 801 with the near-end 71 of sleeve pipe 7
Coupling together after welding, the far-end 72 of sleeve pipe 7 uses laser-beam welding machine 801 to couple together after welding with the near-end 31 of fixed disk 3.
The material of described adapter sleeve 5 and sleeve pipe 7 is rustless steel or Nitinol, it is ensured that it is applicable to human body and uses.Described Dropbox 2
Employing nitinol alloy wire is made, and described fixed disk 3 uses Nitinol pipe to make, and utilizes the shape memory that Nitinol is good special
Property, super-elasticity and corrosion resistance, meet the job demand of heart volume reduction implant.Described Dropbox 2 is woven into for B alloy wire
Bowl structure.Described Dropbox 2 by compressing to B alloy wire mesh grid pipe, such as, may utilize mould and is limited to preboarding
Shape, shapes through vacuum heat, and processing is got up more convenient.
Further embodiment, with reference to a kind of heart volume reduction implant of Fig. 5, including contractile Dropbox 2 and described Dropbox 2
On choked flow film 3, and be connected and be positioned at the fixed disk 4 of described Dropbox 2 one end with described Dropbox 2, described Dropbox 2 is in bowl-shape.
Being connected by sleeve pipe 7 between described fixed disk 4 and Dropbox 2, described Dropbox 2 uses cochrome silk to make, and described fixed disk 4 is adopted
Make with cochrome, utilize anticorrosive, the acid resistance of cochrome, and its good-toughness, characteristic that toxicity is low, the suitableeest
Close the needs of heart volume reduction.Described fixed disk 4 and sleeve pipe 7 are formed in one, it is simple to the processing of fixed disk 4, such as, can pass through handle
The cutting of cobalt chromium hollow pipe is fabricated to fixed disk 4, and the part that cobalt chromium hollow tube end does not cut just can be as sleeve pipe 7.
Further embodiment, with reference to a kind of heart volume reduction implant of Fig. 9, including contractile Dropbox 2 and described Dropbox 2
On choked flow film 3, and be connected and be positioned at the fixed disk 4 of described Dropbox 2 one end with described Dropbox 2, described Dropbox 2 is in bowl-shape.
Described choked flow film 3 is to be respectively coated by expanded PTFE (ePTFE) thin film at the inside and outside wall of Dropbox, specifically can use upper strata
EPTFE choked flow film 3 and lower floor ePTFE choked flow film 3 is coated on the inside and outside wall of Dropbox 2 after heat fused, bonding or adhesion process.
Further embodiment, with reference to a kind of heart volume reduction implant 1 of Figure 10, including contractile Dropbox 2 and described net
Choked flow film 3 on dish 2, and be connected and be positioned at the fixed disk 4 of described Dropbox 2 one end with described Dropbox 2, described Dropbox 2 is in bowl
Shape, described Dropbox 2 includes rounded edge 21.Described choked flow film 3 is to cover polyester (PET) thin film at Dropbox 2 inwall, tool
Body can use the inwall at the edge 21 that PET choked flow film 3 is sewn to Dropbox 2 by stitching thread 1001 to prepare.
According to above-mentioned principle, the present invention can also carry out suitable change and amendment to above-mentioned embodiment.Therefore, this
Bright it is not limited to detailed description of the invention disclosed and described above, some modifications and changes of the present invention be should also be as falling into this
In the scope of the claims of invention.
Claims (10)
1. a heart volume reduction implant, it is characterised in that: include the choked flow film in contractile Dropbox and described Dropbox and
Be connected and be positioned at the fixed disk of described Dropbox one end with described Dropbox, described Dropbox is bowl-shape.
A kind of heart volume reduction implant the most according to claim 1, it is characterised in that: logical between described Dropbox and fixed disk
Cross telescopic joint.
A kind of heart volume reduction implant the most according to claim 1, it is characterised in that: described Dropbox is by Nitinol
The B alloy wire braiding webmasters such as silk or cochrome silk are compressing.
A kind of heart volume reduction implant the most according to claim 1, it is characterised in that: described fixed disk uses Nitinol
Or cochrome makes.
A kind of heart volume reduction implant the most according to claim 1, it is characterised in that: set near the end of described fixed disk
Put at least one anchor thorn.
A kind of heart volume reduction implant, it is characterised in that: described fixed disk and sleeve pipe are
One-body molded.
A kind of heart volume reduction implant the most according to claim 1, it is characterised in that: the material of described sleeve pipe is rustless steel
Or Nitinol.
A kind of heart volume reduction implant the most according to claim 2, it is characterised in that: one end of described Dropbox is provided with connection
Set.
A kind of heart volume reduction implant the most according to claim 1, it is characterised in that: described choked flow film is to process through heat seal
After be coated on the polytetrafluoroethylene film of the inside and outside wall of Dropbox.
A kind of heart volume reduction implant the most according to claim 1, it is characterised in that: described choked flow film is sutured place
The mylar of Dropbox inwall it is coated on after reason.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610805723.8A CN106214289A (en) | 2016-09-05 | 2016-09-05 | A kind of heart volume reduction implant |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610805723.8A CN106214289A (en) | 2016-09-05 | 2016-09-05 | A kind of heart volume reduction implant |
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| CN106214289A true CN106214289A (en) | 2016-12-14 |
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| CN201610805723.8A Pending CN106214289A (en) | 2016-09-05 | 2016-09-05 | A kind of heart volume reduction implant |
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Cited By (13)
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| CN106667539A (en) * | 2017-01-12 | 2017-05-17 | 上海心瑞医疗科技有限公司 | Intervention system arranged at rear of isolating device |
| WO2018217921A1 (en) * | 2017-05-23 | 2018-11-29 | Harmony Development Group, Inc. | Tethered implantable device having a vortical intracardiac velocity adjusting balloon |
| WO2018219151A1 (en) * | 2017-06-02 | 2018-12-06 | 上海微创医疗器械（集团）有限公司 | Medical apparatus |
| CN109303581A (en) * | 2018-12-03 | 2019-02-05 | 上海市东方医院 | A fixation device and system for left ventricular aneurysm |
| CN109820551A (en) * | 2019-02-22 | 2019-05-31 | 北京大学深圳研究生院 | An inflatable ventricular isolation device |
| CN110520078A (en) * | 2017-04-04 | 2019-11-29 | 美敦力瓦斯科尔勒公司 | For the system in delivery catheter will to be loaded into through conduit valve |
| CN110559497A (en) * | 2019-09-19 | 2019-12-13 | 厦门大学附属第一医院 | heart auxiliary support balloon system, manufacturing method thereof and heart auxiliary device |
| CN112438826A (en) * | 2020-11-23 | 2021-03-05 | 江苏臻亿医疗科技有限公司 | Valve prosthesis device for implanting into heart |
| US10940002B2 (en) | 2017-06-28 | 2021-03-09 | Harmony Development Group, Inc. | Force transducting inflatable implant system including a dual force annular transduction implant |
| WO2021121292A1 (en) * | 2019-12-19 | 2021-06-24 | 先健科技(深圳)有限公司 | Heart valve |
| US11167122B2 (en) | 2018-03-05 | 2021-11-09 | Harmony Development Group, Inc. | Force transducting implant system for the mitigation of atrioventricular pressure gradient loss and the restoration of healthy ventricular geometry |
| WO2022143326A1 (en) * | 2020-12-30 | 2022-07-07 | 杭州德晋医疗科技有限公司 | Left ventricular volume-reduction apparatus, left ventricle volume-reduction system and left ventricle volume-reduction method |
| WO2024066785A1 (en) * | 2022-09-26 | 2024-04-04 | 南京圣德医疗科技有限公司 | Valve implantation device assisted by cardiac isolation device |
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