CN106176275B - A kind of skin care item based on Telomerase delaying skin aging disease - Google Patents
A kind of skin care item based on Telomerase delaying skin aging disease Download PDFInfo
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- CN106176275B CN106176275B CN201610781094.XA CN201610781094A CN106176275B CN 106176275 B CN106176275 B CN 106176275B CN 201610781094 A CN201610781094 A CN 201610781094A CN 106176275 B CN106176275 B CN 106176275B
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- 230000004913 activation Effects 0.000 claims abstract description 116
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
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- Gerontology & Geriatric Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
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- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of skin care item based on Telomerase delaying skin aging disease, it is desirable to provide a kind of energy persistently moisturizing, cytotrophy is supplemented comprehensively, the skin care item of delaying skin aging, the skin care item include skin matrix and functional component；Based on skin care item gross mass 100%, the component and its each component weight/mass percentage composition that the functional component includes are：Carnosine 0.01 0.2%, activation telomerase activation component 0.5 5%, VC 0.5 4%, Narcissus Tazetta L. Var extract 0.1 2%, Dunaliella salina algae extract 0.1 3%, Algisium C 0.5 6%, surplus is skin matrix；Belong to cosmetic technical field.
Description
Technical field
The present invention relates to a kind of skin care item, specifically, it is related to a kind of based on Telomerase delaying skin aging disease
Skin care item, belong to cosmetic technical field.
Background technology
Aging is that the degeneration that body is respectively organized, organ dysfunction increases and occurred with the age changes, and is the various biochemistry of body
The general performance of reaction, is inside and outside factors (environmental pollution, stress, heredity etc.) coefficient result.Aging
It is the inexorable law of life process, is inevitable, but anti-aging is possible to.
Human body, to maturation, the division growth of cell, various injected organism tissue duties is all be unable to do without by maturation to aging by immature
The performance of energy is even more so.Therefore, the division growth of cell is the most important mode for maintaining human body function, it is impossible to which imposing external force makes
It stops.External environmental condition (ultraviolet and pollutant), bad life habits further increase cell differentiation.If energy
Enough slow down the division growth speed of cell, it is possible to reach the purpose of anti-aging.Research is found, if keeping cell
In a differential period for comparing early stage, it is possible to store cell capital so that cell is in one than younger state.Prolong
The maturity period of long cell can make skin have more mature cells, also just can preferably prevent the injury of external environment.
Telomere is fissional " timing clock ", and cell often divides once, and telomere is to lose several base-pairs, works as telomere
When shortening to a certain extent, replicative senescence feature occurs in cell, stops propagation, last apoptosis.The normal function of skin
Can be destroyed therewith, self-renewing mechanism inactivation, cuticula is thickening, skin become drys, dry and astringent, furfur, elasticity reduce, it is obscure
It is matt.Telomerase can fill up the defect of DNA clone mechanism, and telomere reparation is extended, allows telomere will not be because of cell
Divide and be lost so that the number of times increase of cell division clone, delaying cell aging.However, Telomerase is in body cell
Hardly expression or expression quantity are very low, and when the telomerase of some chromosomes is reduced to critical length, cell can stop
Only divide, cause procedural cell death.
Therefore, telomerase activation is activated and kept, cell on one's deathbed can be made to increase replication capacity, senile cell is assigned and increases
The ability grown, and appropriate damaged tissue repair, so as to depart from cell cycle, realize the purpose of delaying cell aging.
The content of the invention
It is an object of the invention to provide a kind of energy persistently moisturizing, cytotrophy, the skin care of delaying skin aging are supplemented comprehensively
Product.
Therefore, the technical scheme that the present invention is provided is such：
A kind of skin care item based on Telomerase delaying skin aging disease, including skin matrix and functional component；By skin care
Product gross mass 100% is counted, and the component and its each component weight/mass percentage composition that the functional component includes are：Carnosine 0.01-
0.2%th, activation telomerase activation component 0.5-5%, VC 0.5-4%, Narcissus Tazetta L. Var extract 0.1-2%, Dunaliella salina are carried
Take thing 0.1-3%, Algisium C 0.5-6%；Surplus is skin matrix.
Further, the above-mentioned skin care item based on Telomerase delaying skin aging disease, the activation telomerase activation
Component is mainly made up of 35-50 parts of 20-30 parts of betelnutpalm male flower, 15-25 parts of FRUCTUS TERMINALIAE IMMATURUS and turmeric.
Further, the above-mentioned skin care item based on Telomerase delaying skin aging disease, the activation telomerase activation
Component also includes 8-15 parts of 5-10 parts of addition cynomorium songaricum and ginkgo leaf when preparing.
Further, the above-mentioned skin care item based on Telomerase delaying skin aging disease, the activation Telomerase is lived
Property component prepare when also include addition 3-8 parts of faenum graecum seed.
Further, the above-mentioned skin care item based on Telomerase delaying skin aging disease, the activation Telomerase is lived
The preparation method of property component is as follows：
1) 20-30 parts of betelnutpalm male flower, 15-25 parts of FRUCTUS TERMINALIAE IMMATURUS, 35-50 parts of mixing of turmeric are weighed, mixture is smashed to obtain；
2) 1 is compared according to weight:15-35 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonic wave
Processing extraction, power is 85W, and Extracting temperature is 60-70 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Further, the above-mentioned skin care item based on Telomerase delaying skin aging disease, the activation Telomerase is lived
Property component preparation method in, step 1) also include weighing 20-30 parts of 5-10 part of cynomorium songaricum, 8-15 part of ginkgo leaf and betelnutpalm male flower, it is western
15-25 parts of Chinese olive, 35-50 parts of mixing of turmeric, obtain mixture.
Further, the above-mentioned skin care item based on Telomerase delaying skin aging disease, the activation Telomerase is lived
Property component preparation method in, step 1) also include weighing 3-8 part of faenum graecum seed and 20-30 parts of betelnutpalm male flower, FRUCTUS TERMINALIAE IMMATURUS 15-25
Part, 35-50 parts of mixing of turmeric, obtain mixture.
Further, the above-mentioned skin care item based on Telomerase delaying skin aging disease, the activation Telomerase is lived
Property component preparation method in, step 1) also include weigh 3-8 parts of faenum graecum seed, 5-10 parts of cynomorium songaricum, 8-15 parts of ginkgo leaf and Bin
Bulky colored 20-30 parts, 15-25 parts of FRUCTUS TERMINALIAE IMMATURUS, the mixing of 35-50 parts of turmeric, obtain mixture.
Further, the above-mentioned skin care item based on Telomerase delaying skin aging disease, the formulation of the skin care item
For any one in facial mask, face cream, emulsion, eye cream, Essence.
Compared with prior art, the technical scheme that the present invention is provided has the following advantages that：
1st, the activation telomerase activation component that the present invention is provided is by starting Telomerase, forbidding Telomerase to reverse transcription ferment
Element, promotes the most effective active component of molecule, changes extracellular matrix ECM synthesis, increases protease, activates telomere
Enzyme promotive factor, induces the expression of Telomerase, increases the quantity of fibrocyte, cell is constantly grown；And activation Telomerase is lived
Property component and Narcissus Tazetta L. Var extract act synergistically, effectively slow down cell propagation, suppress the active component of cell differentiation, so as to hinder
Only cell senescence, extends the maturity period of cell, and the injury of outside environmental elements is resisted well；Further, activation telomerase activation
Component acts synergistically with VC, the speed reduction by 27% that can shorten telomere length, further enhances the activity of Telomerase, makes thin
Born of the same parents' life 50%.
2nd, the activation telomerase activation component that provides of the present invention and Algisium C synergy, can be with
The metabolic normalization of horn cell is induced, promotes fibrocyte differentiation indirectly, while promoting the synthesis of collagen, is promoted true
Cortex is rebuild, and is stimulated cell neogenesis, is fed cytotrophy comprehensively in time, reinforces cell membrane, protect Skin Cell from free radical
Injury, effectively suppresses the release of inflammatory factor, prevents inflammation from over-expressing, and creates deep layer hydration ball, momentary recovery cell
Water lock function, optimizes skin moisturizing degree, realizes long-acting moisturizing, delaying skin aging.
3rd, the activation telomerase activation component and carnosine and Dunaliella salina algae extract that the present invention is provided act synergistically, effectively
The elasticity of holding structure albumen (collagen, elastin laminin etc.), resists Cross-linked, repairs sugar chain, adjusts acid-base balance, and
Oxidative damage is prevented, suppresses glycosylation, suppresses MMP-1, protects Skin Cell from UVB damage, delay telomere length
Shortening speed, promote cell rejuvenate, delaying skin aging.
Embodiment
Technical scheme is described in further detail with reference to specific embodiment, but the invention is not restricted to following
Embodiment.It is worth noting that, unless otherwise indicated, various components used in the present invention are this area current material, can
Bought by commercial channel and obtain or be made by existing method.
Wherein：Narcissus Tazetta L. Var extract and Dunaliella salina algae extract are purchased from the Hao Bo Co., Ltds of Guangzhou hundred.
Embodiment 1
A kind of facial mask based on Telomerase delaying skin aging disease that the present invention is provided, based on facial mask gross mass 100g,
Each component and its percentage composition are：Carnosine 0.01g, activation telomerase activation component 1g, VC1g, Narcissus Tazetta L. Var extract 0.5g,
Dunaliella salina algae extract 0.1g, Algisium C 2g, surplus is mask matrix.
The activation telomerase activation component is made by following step：
1) betelnutpalm male flower 20g, FRUCTUS TERMINALIAE IMMATURUS 25g, turmeric 35g mixing are weighed, mixture is smashed to obtain；
2) 1 is compared according to weight:15 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 70 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Embodiment 2
A kind of facial mask based on Telomerase delaying skin aging disease that the present invention is provided, based on facial mask gross mass 100g,
Each component and its following percentage composition of content are：Carnosine 0.05g, activation telomerase activation component 0.5g, VC0.5g, Narcissus Tazetta L. Var
Extract 1g, Dunaliella salina algae extract 1g, Algisium C 1g, surplus is mask matrix.
The preparation method of the activation telomerase activation component is as follows：
1) betelnutpalm male flower 25g, FRUCTUS TERMINALIAE IMMATURUS 20g, turmeric 50g, cynomorium songaricum 5g and ginkgo leaf 10g mixing are weighed, mixture is smashed to obtain；
2) 1 is compared according to weight:20 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 60 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Embodiment 3
A kind of facial mask based on Telomerase delaying skin aging disease that the present invention is provided, based on facial mask gross mass 100g,
Each component and its percentage composition are：Carnosine 0.15g, activation telomerase activation component 2g, VC2g, Narcissus Tazetta L. Var extract 1.5g,
Dunaliella salina algae extract 1.5g, Algisium C 5g, surplus is mask matrix.
The preparation method of the activation telomerase activation component is as follows：
1) betelnutpalm male flower 30g, FRUCTUS TERMINALIAE IMMATURUS 15g, turmeric 40g, cynomorium songaricum 10g, ginkgo leaf 8g and faenum graecum seed 8g mixing, powder are weighed
It is pure to obtain mixture；
2) 1 is compared according to weight:35 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 65 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Mask matrix in embodiment 1-3, based on mask matrix gross mass 100g, each component and its weight percent are such as
Under：
Mask matrix preparation method：
The deionized water in A phases is first heated to 80-90 DEG C, A phase clouts is then added, is uniformly dispersed, and homogeneous is to nothing
Particle, when being cooled to 50-60 DEG C, adds B phases and adjusts pH to 6-7, continuation stirring is cooled to 45 DEG C and obtains mixture, adds C phases, stir
Mix uniform, be cooled to 35 DEG C and produce.
The preparation method of the facial mask of the embodiment of the present invention 1 to 3 is：Flesh is weighed by any one group of mass number in embodiment 1 to 3
Peptide, activation telomerase activation component, VC, Narcissus Tazetta L. Var extract, Dunaliella salina algae extract, methyl-monosilane alcohol mannuronic acid
Ester, after being stirred with a small amount of deionized water dissolving, is added in mixture made from above-mentioned A, B phase together with above-mentioned C phases, stirring
Uniformly, 35 DEG C are cooled to produce.
Embodiment 4
A kind of face cream based on Telomerase delaying skin aging disease that the present invention is provided, based on face cream gross mass 100g,
Each component and its percentage composition are：Carnosine 0.2g, activation telomerase activation component 2.5g, VC3g, Narcissus Tazetta L. Var extract 0.5g,
Dunaliella salina algae extract 0.5g, Algisium C 3g, surplus are face cream matrix.
The activation telomerase activation component is made by following step：
1) betelnutpalm male flower 28g, FRUCTUS TERMINALIAE IMMATURUS 18g, turmeric 45g mixing are weighed, mixture is smashed to obtain；
2) 1 is compared according to weight:18 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 70 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Embodiment 5
A kind of face cream based on Telomerase delaying skin aging disease that the present invention is provided, based on face cream gross mass 100g,
Each component and its percentage composition are：Carnosine 0.1g, activation telomerase activation component 3g, VC1.5g, Narcissus Tazetta L. Var extract 2g, salt
Raw Du Shi algae extracts 2g, Algisium C 1.5g, surplus is face cream matrix.
The preparation method of the activation telomerase activation component is as follows：
1) betelnutpalm male flower 25g, FRUCTUS TERMINALIAE IMMATURUS 18g, turmeric 38g, cynomorium songaricum 5g and ginkgo leaf 10g mixing are weighed, mixture is smashed to obtain；
2) 1 is compared according to weight:20 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 60 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Embodiment 6
A kind of face cream based on Telomerase delaying skin aging disease that the present invention is provided, based on face cream gross mass 100g,
Each component and its percentage composition are：Carnosine 0.05g, activation telomerase activation component 3.5g, VC 4g, Narcissus Tazetta L. Var extract
1.5g, Dunaliella salina algae extract 3g, Algisium C 2.5g, surplus are face cream matrix.
The preparation method of the activation telomerase activation component is as follows：
1) betelnutpalm male flower 30g, FRUCTUS TERMINALIAE IMMATURUS 15g, turmeric 38g, cynomorium songaricum 8g, ginkgo leaf 15g and faenum graecum seed 6g mixing, powder are weighed
It is pure to obtain mixture；
2) 1 is compared according to weight:30 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 65 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Face cream matrix in embodiment 4-6, based on face cream matrix gross mass 100g, each component and its weight percent are such as
Under：
Face cream Matrix formulation procedure is as follows：
1) A phases are heated with stirring to 80 DEG C or so, it is standby；
2) deionized water in B phases is first heated to 80-90 DEG C, then adds B phase clouts, stirring and dissolving and homogeneous to nothing
Particle, is added after the A phases pre-processed, homogeneous 3-5min, is added C phases and is adjusted pH to 6-7, after stirring, insulated and stirred
Froth breaking, is cooled to 45 DEG C or so, adds D phases, stirs, be cooled to 35 DEG C and produce.
The preparation method of the face cream of the embodiment of the present invention 4 to 6 is：By the flesh that any one group of mass number is weighed in embodiment 4 to 6
Peptide, activation telomerase activation component, VC, Narcissus Tazetta L. Var extract, Dunaliella salina algae extract, methyl-monosilane alcohol mannuronic acid
Ester, first uses a small amount of deionized water dissolving, after stirring, and mixture prepared by above-mentioned A, B, C phase is added together with above-mentioned D phases
In, stir, be cooled to 35 DEG C and produce.
Embodiment 7
A kind of emulsion based on Telomerase delaying skin aging disease that the present invention is provided, based on emulsion gross mass 100g,
Each component and its percentage composition are：Carnosine 0.1g, activation telomerase activation component 4g, VC 1g, Narcissus Tazetta L. Var extract 1g, salt
Raw Du Shi algae extracts 2.5g, Algisium C 4g, surplus is emulsion matrix.
The activation telomerase activation component is made by following step：
1) betelnutpalm male flower 25g, FRUCTUS TERMINALIAE IMMATURUS 15g, turmeric 50g mixing are weighed, mixture is smashed to obtain；
2) 1 is compared according to weight:25 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 70 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Embodiment 8
A kind of emulsion based on Telomerase delaying skin aging disease that the present invention is provided, based on emulsion gross mass 100g,
Each component and its percentage composition are：Carnosine 0.15g, activation telomerase activation component 4.5g, VC 2g, Narcissus Tazetta L. Var extract
0.8g, Dunaliella salina algae extract 3g, Algisium C 5.5g, surplus is emulsion matrix.
The preparation method of the activation telomerase activation component is as follows：
1) betelnutpalm male flower 20g, FRUCTUS TERMINALIAE IMMATURUS 22g, turmeric 35g, cynomorium songaricum 6g and ginkgo leaf 12g mixing are weighed, mixture is smashed to obtain；
2) 1 is compared according to weight:20 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 60 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Embodiment 9
A kind of emulsion based on Telomerase delaying skin aging disease that the present invention is provided, based on emulsion gross mass 100g,
Each component and its percentage composition are：Carnosine 0.08g, activation telomerase activation component 5g, VC4g, Narcissus Tazetta L. Var extract 2g, salt
Raw Du Shi algae extracts 0.1g, Algisium C 0.5g, surplus is emulsion matrix.
The preparation method of the activation telomerase activation component is as follows：
1) betelnutpalm male flower 30g, FRUCTUS TERMINALIAE IMMATURUS 18g, turmeric 38g, cynomorium songaricum 8g, ginkgo leaf 15g and faenum graecum seed 3g mixing, powder are weighed
It is pure to obtain mixture；
2) 1 is compared according to weight:30 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 65 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Emulsion matrix in embodiment 7-9, based on emulsion matrix gross mass 100g, each component and its weight percent are such as
Under：
The preparation method of emulsion matrix：
1) A phases are heated with stirring to 80 DEG C or so, standby；
2) deionized water in B phases is first heated to 80-90 DEG C, then adds B phase clouts, stirring and dissolving and homogeneous to nothing
Particle, is added after the A phases pre-processed, homogeneous 3-5min, insulated and stirred froth breaking, is cooled to 45 DEG C or so, is added C phases, is stirred
Mix uniform, be cooled to 35 DEG C and produce.
The preparation method of the emulsion of the embodiment of the present invention 7 to 9 is：Any one group of mass number of embodiment 7-9 is weighed into carnosine, swashed
Active end telomerase activity component, VC, Narcissus Tazetta L. Var extract, Dunaliella salina algae extract, Algisium C, first
A small amount of deionized water dissolving is used, after stirring, is added together with above-mentioned C phases in mixture prepared by above-mentioned A, B phase, stirring is equal
It is even, it is cooled to 35 DEG C and produces.
Embodiment 10
A kind of eye cream based on Telomerase delaying skin aging disease that the present invention is provided, based on eye cream gross mass 100g,
Each component and its percentage composition are：Carnosine 0.2g, activation telomerase activation component 2g, VC 1g, Narcissus Tazetta L. Var extract 2g, salt
Raw Du Shi algae extracts 2g, Algisium C 6g, surplus is eye cream matrix.
The activation telomerase activation component is made by following step：
1) betelnutpalm male flower 25g, FRUCTUS TERMINALIAE IMMATURUS 16g, turmeric 45g mixing are weighed, mixture is smashed to obtain；
2) 1 is compared according to weight:25 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 70 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Embodiment 11
A kind of eye cream based on Telomerase delaying skin aging disease that the present invention is provided, based on eye cream gross mass 100g,
Each component and its percentage composition are：Carnosine 0.1g, activation telomerase activation component 5g, VC 3g, Narcissus Tazetta L. Var extract 0.1g,
Dunaliella salina algae extract 0.1g, Algisium C 2g, surplus are eye cream matrix.
The preparation method of the activation telomerase activation component is as follows：
1) betelnutpalm male flower 25g, FRUCTUS TERMINALIAE IMMATURUS 15g, turmeric 35g, cynomorium songaricum 8g and ginkgo leaf 10g mixing are weighed, mixture is smashed to obtain；
2) 1 is compared according to weight:20 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 60 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Embodiment 12
A kind of eye cream based on Telomerase delaying skin aging disease that the present invention is provided, based on eye cream gross mass 100g,
Each component and its percentage composition are：Carnosine 0.12g, activation telomerase activation component 1g, VC4g, Narcissus Tazetta L. Var extract 1.5g,
Dunaliella salina algae extract 3g, Algisium C 4g, surplus are eye cream matrix.
The preparation method of the activation telomerase activation component is as follows：
1) betelnutpalm male flower 20g, FRUCTUS TERMINALIAE IMMATURUS 20g, turmeric 35g and faenum graecum seed 5g mixing are weighed, mixture is smashed to obtain；
2) 1 is compared according to weight:30 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 65 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Eye cream matrix in embodiment 10-12, based on eye cream matrix gross mass 100g, each component and its weight percent are such as
Under：
The preparation method of eye cream matrix：
1) A phases are heated with stirring to 80 DEG C or so, standby；
2) deionized water in B phases is first heated to 80-90 DEG C, then adds B phase clouts, simultaneously homogeneous is equal for stirring and dissolving
It is even, add after A phases and C phases, homogeneous 3-6min, insulated and stirred froth breaking, be cooled to 45 DEG C or so, add D phases, stir,
35 DEG C are cooled to produce.
The preparation method of the eye cream of the embodiment of the present invention 10 to 12 is：Any one group of mass number of embodiment 10-12 is weighed into flesh
Peptide, activation telomerase activation component, VC, Narcissus Tazetta L. Var extract, Dunaliella salina algae extract, methyl-monosilane alcohol mannuronic acid
After ester is first stirred with a small amount of deionized water dissolving, added together with above-mentioned D phases in mixture prepared by above-mentioned A, B, C phase,
Stir, be cooled to 35 DEG C and produce.
Embodiment 13
A kind of Essence based on Telomerase delaying skin aging disease that the present invention is provided, by Essence gross mass 100g
Meter, each component and its percentage composition are：Carnosine 0.1g, activation telomerase activation component 1g, VC1g, Narcissus Tazetta L. Var extract 2g,
Dunaliella salina algae extract 3g, Algisium C 0.5g, surplus are Essence matrix.
The activation telomerase activation component is made by following step：
1) betelnutpalm male flower 25g, FRUCTUS TERMINALIAE IMMATURUS 15g, turmeric 40g mixing are weighed, mixture is smashed to obtain；
2) 1 is compared according to weight:25 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 70 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Embodiment 14
A kind of Essence based on Telomerase delaying skin aging disease that the present invention is provided, by Essence gross mass 100g
Meter, each component and its percentage composition are：Carnosine 0.09g, activation telomerase activation component 4g, VC 0.5g, Narcissus Tazetta L. Var extract
0.5g, Dunaliella salina algae extract 0.5g, Algisium C 3g, surplus are Essence matrix.
The preparation method of the activation telomerase activation component is as follows：
1) betelnutpalm male flower 23g, FRUCTUS TERMINALIAE IMMATURUS 17g, turmeric 40g, cynomorium songaricum 10g and ginkgo leaf 15g mixing are weighed, smashing to mix
Thing；
2) 1 is compared according to weight:20 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 60 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Embodiment 15
A kind of Essence based on Telomerase delaying skin aging disease that the present invention is provided, by Essence gross mass 100g
Meter, each component and its percentage composition are：Carnosine 0.05g, activation telomerase activation component 1g, VC1.5g, Narcissus Tazetta L. Var extract
1g, Dunaliella salina algae extract 1g, Algisium C 1.5g, surplus are Essence matrix.
The preparation method of the activation telomerase activation component is as follows：
1) betelnutpalm male flower 20g, FRUCTUS TERMINALIAE IMMATURUS 15g, turmeric 35g and faenum graecum seed 3g mixing are weighed, mixture is smashed to obtain；
2) 1 is compared according to weight:30 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and Extracting temperature is 65 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation
Water elution is near colourless, then with 5 times of 50% ethanol elutions of amount, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and freezing is done
It is dry to activate telomerase activation component.
Essence matrix in embodiment 13-15, based on Essence matrix gross mass 100g, each component and its weight percent
Than as follows：
The preparation method of Essence matrix：
The deionized water in A phases is first heated to 80-90 DEG C, A phase clouts are then added, stirring and dissolving is uniformly dispersed, and
Homogeneous is cooled to 45 DEG C, adds C phases, stirring is equal to without particle, adding after B phases after homogeneous 2-4min again, insulated and stirred froth breaking
It is even, it is cooled to 35 DEG C and produces.
The preparation method of the Essence of the embodiment of the present invention 13 to 15 is：Weighed by any one group of mass number of embodiment 13-15
Carnosine, activation telomerase activation component, VC, Narcissus Tazetta L. Var extract, Dunaliella salina algae extract, methyl-monosilane alcohol sweet dew alditol
Acid esters, after first being stirred with a small amount of deionized water dissolving, is added in mixture prepared by above-mentioned A, B phase together with above-mentioned C phases,
Stir, be cooled to 35 DEG C and produce.
Comparative example 1
A kind of facial mask based on Telomerase delaying skin aging disease that comparative example 1 is provided, only adds mask matrix.
Comparative example 2
Comparative example 2 is a certain commercially available anti-ageing face mask of purchase.
Comparative example 3
A kind of face cream based on Telomerase delaying skin aging disease that comparative example 3 is provided, only adds face cream matrix.
Comparative example 4
Comparative example 4 is a certain commercially available anti-aging face cream of purchase.
Comparative example 5
A kind of emulsion based on Telomerase delaying skin aging disease that comparative example 5 is provided, only adds emulsion matrix.
Comparative example 6
Comparative example 6 is a certain commercially available anti-aging emulsion of purchase.
Comparative example 7
A kind of eye cream based on Telomerase delaying skin aging disease that comparative example 7 is provided, only adds eye cream matrix.
Comparative example 8
Comparative example 8 is a certain commercially available anti-aging eye cream of purchase.
Comparative example 9
A kind of eye cream based on Telomerase delaying skin aging disease that comparative example 9 is provided, only adds Essence matrix.
Comparative example 10
Comparative example 10 is a certain commercially available anti-aging Essence of purchase.
In order to be better described the present invention the skin care item based on Telomerase delaying skin aging disease have significantly delay
Effect of skin aging, using the Flexible change of skin and dermatoglyph degree as evaluation index, carries out following test：
First, skin elasticity is tested
1st, test population：Average age is 170 women of 35-45 Sui, and skin health not damaged is divided into 17 groups, every group
10 people.
2nd, test sample：The facial mask of embodiment 1, the facial mask of embodiment 3, the face cream of embodiment 5, the emulsion of embodiment 7, reality
Apply the emulsion of example 9, the eye cream of embodiment 11, the Essence of embodiment 15, comparative example 1-10 skin-protection product.
3rd, method of testing：
(1) it is experiment position at 10 centimeters away from palm base portion of the left and right inboard arm of subject of selection.
(2) skin elasticity tester (Cutometer dual MPA580) determination experiment portion is used by technical staff first
The skin elasticity numerical value before cosmetics is smeared in position, and every is surveyed five times, is averaged.
(3) every group of subject smears test sample in left arm Test sites, smears sooner or later daily twice, right arm experiment
Position is control, not swab.During experiment, subject can not smear any other cosmetics in Test sites.
(4) every group of subject continuously using test sample one week, surrounding and after eight weeks, is being surveyed using skin elasticity tester
Try skin elasticity numerical value.During test, subject cleans position is smeared, and is determined and smeared using skin elasticity tester by tester
The elastic numerical value at position, every is surveyed five times, is averaged.
(5) numerical value that every group of subject position is measured every time is counted, its skin elasticity changing rule is analyzed, so that really
Determine effect of skin elasticity improvement.It the results are shown in Table shown in 1.
Table 1
| 0 week | 1 week | 4 weeks | 8 weeks | Changing value | Rate of change (%) | |
| Embodiment 1 | 0.598 | 0.612 | 0.653 | 0.754 | 0.156 | 26.087 |
| Embodiment 3 | 0.602 | 0.642 | 0.704 | 0.810 | 0.208 | 34.551 |
| Embodiment 5 | 0.631 | 0.664 | 0.732 | 0.873 | 0.242 | 38.352 |
| Embodiment 7 | 0.554 | 0.567 | 0.617 | 0.724 | 0.170 | 30.686 |
| Embodiment 9 | 0.536 | 0.558 | 0.628 | 0.755 | 0.219 | 40.858 |
| Embodiment 11 | 0.606 | 0.671 | 0.712 | 0.846 | 0.240 | 39.604 |
| Embodiment 15 | 0.618 | 0.647 | 0.693 | 0.798 | 0.180 | 29.126 |
| Comparative example 1 | 0.567 | 0.570 | 0.572 | 0.578 | 0.011 | 1.940 |
| Comparative example 2 | 0.546 | 0.553 | 0.571 | 0.599 | 0.053 | 9.707 |
| Comparative example 3 | 0.584 | 0.590 | 0.596 | 0.601 | 0.017 | 2.911 |
| Comparative example 4 | 0.579 | 0.596 | 0.631 | 0.689 | 0.110 | 18.998 |
| Comparative example 5 | 0.613 | 0.620 | 0.627 | 0.630 | 0.017 | 2.773 |
| Comparative example 6 | 0.605 | 0.618 | 0.647 | 0.705 | 0.100 | 16.529 |
| Comparative example 7 | 0.621 | 0.628 | 0.633 | 0.639 | 0.018 | 2.899 |
| Comparative example 8 | 0.618 | 0.627 | 0.659 | 0.742 | 0.124 | 20.065 |
| Comparative example 9 | 0.624 | 0.628 | 0.630 | 0.638 | 0.014 | 2.244 |
| Comparative example 10 | 0.586 | 0.594 | 0.621 | 0.657 | 0.071 | 12.116 |
2nd, dermatoglyph degree is tested
1st, test population：Average age is 170 women of 35-45 Sui, and skin health not damaged is divided into 17 groups, every group
10 people.
2nd, test sample：The facial mask of embodiment 1, the facial mask of embodiment 3, the face cream of embodiment 5, the emulsion of embodiment 7, reality
Apply the emulsion of example 9, the eye cream of embodiment 11, the Essence of embodiment 15, comparative example 1-10 skin-protection product.
3rd, method of testing：
(1) it is Test sites at 10 centimeters away from palm base portion of the left and right inboard arm of subject of selection.
(2) skin image analysis system (Skin Visiometer SV600) determination experiment is used by technical staff first
The dermatoglyph degree before cosmetics is smeared at position, and every is surveyed five times, is averaged.
(3) every group of subject smears test sample in left arm Test sites, smears sooner or later daily twice, right arm experiment
Position is control, not swab.During experiment, subject can not smear any other cosmetics in Test sites.
(4) every group of subject continuously using cosmetics one week, surrounding and after eight weeks, is being surveyed using skin image analysis system
Try dermatoglyph degree.During test, subject cleans position is smeared, and is determined and smeared using skin image analysis system by tester
The dermatoglyph degree at position, every is surveyed five times, is averaged.
(5) numerical value that every group of subject position is measured every time is counted, its dermatoglyph changing rule is analyzed, so that really
Determine effect of dermatoglyph improvement.It the results are shown in Table shown in 2.
Table 2
The result of Tables 1 and 2 shown, the embodiment of the present invention 1,3,5,7,9,11,15 is declined based on Telomerase delaying skin
The skin care item of old disease, compared with the skin care item of comparative example 1,3,5,7,9, i.e., on the basis of skin matrix, with the addition of flesh
Peptide, activation telomerase activation component, VC, Narcissus Tazetta L. Var extract, Dunaliella salina algae extract, methyl-monosilane alcohol mannuronic acid
Ester Multiple components, hence it is evident that improve the improvement to skin elasticity and dermatoglyph degree, and with comparative example 2,4,6,8,10
Experimental data compare, the skin care item of the invention based on Telomerase delaying skin aging disease, its anti-aging effects are also bright
It is aobvious to be better than commercially available anti-ageing face mask, anti-aging face cream, anti-aging emulsion, anti-aging eye cream and anti-aging Essence.
In summary, the activation telomerase activation in the skin care item of the invention based on Telomerase delaying skin aging disease
Component is rationally compounded by cynomorium songaricum, ginkgo leaf, faenum graecum seed, betelnutpalm male flower, FRUCTUS TERMINALIAE IMMATURUS and turmeric, and is carried with carnosine, VC, Narcissus Tazetta L. Var
Take thing, Dunaliella salina algae extract, Algisium C synergy, can persistently moisturizing, comprehensively supplement carefully
Born of the same parents' nutrition, notable delaying skin aging.
Claims (8)
1. a kind of skin care item based on Telomerase anti-aging disease, it is characterised in that including skin matrix and functional component；Press
Skin care item gross mass 100% is counted, and the component and its each component weight/mass percentage composition that the functional component includes are：Carnosine 0.01-
0.2%th, activation telomerase activation component 0.5-5%, VC 0.5-4%, Narcissus Tazetta L. Var extract 0.1-2%, Dunaliella salina are carried
Take thing 0.1-3%, Algisium C 0.5-6%；Surplus is skin matrix；
The activation telomerase activation component is mainly made up of 35-50 parts of 20-30 parts of betelnutpalm male flower, 15-25 parts of FRUCTUS TERMINALIAE IMMATURUS and turmeric.
2. the skin care item according to claim 1 based on Telomerase anti-aging disease, it is characterised in that the activated end
Telomerase activity component also includes 8-15 parts of 5-10 parts of addition cynomorium songaricum and ginkgo leaf when preparing.
3. the skin care item according to claim 1 or 2 based on Telomerase anti-aging disease, it is characterised in that described to swash
Active end telomerase activity component also includes 3-8 parts of faenum graecum seed of addition when preparing.
4. the skin care item according to claim 1 based on Telomerase anti-aging disease, it is characterised in that the activated end
The preparation method of telomerase activity component is as follows：
1) 20-30 parts of betelnutpalm male flower, 15-25 parts of FRUCTUS TERMINALIAE IMMATURUS, 35-50 parts of mixing of turmeric are weighed, mixture is smashed to obtain；
2) 1 is compared according to weight:15-35 ratio is by step 1) in mixture mixed with deionized water, carry out ultrasonication
Extraction, power is 85W, and extract temperature is 60-70 DEG C, and extract solution is centrifuged, obtains supernatant by extraction time 30min.
3) deionized water is added in supernatant to mix, be added in preprocessed good macroporous resin column, first with distillation washing
Take off near colourless, then with 5 times of 50% ethanol elutions of amount, collect ethanol eluate, and be concentrated under reduced pressure into no alcohol taste, freeze-drying
Telomerase activation component must be activated.
5. the skin care item according to claim 4 based on Telomerase anti-aging disease, it is characterised in that step 1) also wrap
Include and weigh 5-10 parts of cynomorium songaricum, 8-15 parts of ginkgo leaf and mixed with 20-30 parts of betelnutpalm male flower, 15-25 parts of FRUCTUS TERMINALIAE IMMATURUS, 35-50 parts of turmeric, obtain
Mixture.
6. the skin care item according to claim 4 based on Telomerase anti-aging disease, it is characterised in that step 1) also wrap
Include and weigh 3-8 parts of faenum graecum seed and mixed with 20-30 parts of betelnutpalm male flower, 15-25 parts of FRUCTUS TERMINALIAE IMMATURUS, 35-50 parts of turmeric, obtain mixture.
7. the skin care item according to claim 4 based on Telomerase anti-aging disease, it is characterised in that step 1) also wrap
Include and weigh 3-8 parts of faenum graecum seed, 5-10 parts of cynomorium songaricum, 8-15 parts of ginkgo leaf and 20-30 parts of betelnutpalm male flower, 15-25 parts of FRUCTUS TERMINALIAE IMMATURUS, turmeric
35-50 parts of mixing, obtain mixture.
8. the skin care item according to claim 1 based on Telomerase anti-aging disease, it is characterised in that described skin care
The formulation of product is any one in facial mask, face cream, emulsion, eye cream, Essence.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610781094.XA CN106176275B (en) | 2016-08-31 | 2016-08-31 | A kind of skin care item based on Telomerase delaying skin aging disease |
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| CN201610781094.XA CN106176275B (en) | 2016-08-31 | 2016-08-31 | A kind of skin care item based on Telomerase delaying skin aging disease |
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| CN106176275A CN106176275A (en) | 2016-12-07 |
| CN106176275B true CN106176275B (en) | 2017-09-15 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US10966948B2 (en) | 2019-07-23 | 2021-04-06 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| US11197841B2 (en) | 2019-07-23 | 2021-12-14 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| US11931331B2 (en) | 2018-07-27 | 2024-03-19 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| US11969454B2 (en) | 2019-11-19 | 2024-04-30 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
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| CN107837208B (en) * | 2017-08-17 | 2021-02-02 | 上海联衡生物科技有限公司 | Preparation method of telomerase composition and application of telomerase composition in anti-aging and anti-retrogrowth cosmetics |
| CN108078857A (en) * | 2018-01-22 | 2018-05-29 | 尹淑珍 | A kind of anti crease and anti senile old essence lotion and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1951366A (en) * | 2006-11-03 | 2007-04-25 | 南风化工集团股份有限公司 | A skin moisture-keeping wrinkle-resisting essence and production method thereof |
| CN102711721B (en) * | 2009-08-28 | 2013-09-25 | 玫琳凯公司 | Skin care formulations |
| CN102440926B (en) * | 2011-02-10 | 2013-06-19 | 漳州市格莱雅化妆品有限公司 | Daffodil whitening cream cosmetic |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US11806327B2 (en) | 2018-07-27 | 2023-11-07 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| US11931331B2 (en) | 2018-07-27 | 2024-03-19 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| US10966948B2 (en) | 2019-07-23 | 2021-04-06 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| US11197841B2 (en) | 2019-07-23 | 2021-12-14 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| US11969454B2 (en) | 2019-11-19 | 2024-04-30 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
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| Publication number | Publication date |
|---|---|
| CN106176275A (en) | 2016-12-07 |
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