CN106174485A - There is the enzyme composition of kidney-reinforcing Yang strengthening effect, effervescent tablet and preparation method - Google Patents
There is the enzyme composition of kidney-reinforcing Yang strengthening effect, effervescent tablet and preparation method Download PDFInfo
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- CN106174485A CN106174485A CN201610541053.3A CN201610541053A CN106174485A CN 106174485 A CN106174485 A CN 106174485A CN 201610541053 A CN201610541053 A CN 201610541053A CN 106174485 A CN106174485 A CN 106174485A
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Abstract
The present invention relates to the enzyme composition with kidney-reinforcing Yang strengthening effect, this enzyme composition includes following component: probiotic bacteria 1 15 weight portion, enzyme composition stock solution 10 120 weight portion and Chinese medicine extract 10 80 weight portion；Described enzyme composition is to mix with enzyme composition stock solution after the sterilized technique of Chinese medicine extract, and inoculates beneficial flora and carry out sealed fermenting and form；Chinese medicine extract is extracted by the crude drug of following weight portion and forms: Rhizoma Dioscoreae 2 10 parts, Stichopus japonicus 2 10 parts, Morchella esculenta (L.) Pers 18 parts, Rhizoma Imperatae 2 10 parts, Quinoa 28 parts, Radix seu Fructus Rosae Sericeae 18 parts, Hippocampus 0.5 6 parts, Rhizoma Curculiginis 0.5 6 parts, Medulla Helianthi 0.2 3 parts, 0.5 6 parts of Fructus Jujubae and Radix Notoginseng 0.5 5 parts.Probiotic bacteria and functional oligose are used in combination by this enzyme composition, and add Chinese medicine ingredients, have kidney-reinforcing Yang strengthening, effect of benefit essence QI invigorating.
Description
Technical field
The invention belongs to field of health care food, particularly to a kind of, there is the enzyme composition of kidney-reinforcing Yang strengthening effect, effervescent
Sheet and preparation method.
Background technology
Ferment is in recent years to rise in Japan, a kind of functional food of TaiWan, China, and it is with fermented by mixed bacterium such as yeast
The plant fermented liquid of more than 50 kinds fruit and vegetable gained.Ferment is rich in the functional cometabolism from more than 50 kinds fruit and vegetable materials
Product, such as polyphenol and oligosaccharide.The at present research to fruit-vegerable ferment focuses mostly on adjusting and improving at raw material, strain and fermentation technology
Aspect, also occurs in that the health food that some add the ferment of probiotic bacterias and prepared by ferment simultaneously.Probiotics fermention fruit and vegerable, can
Activate the effective efficiency composition in fruit and vegerable, active effect material of dissolution more elite.As number of patent application is
201410087224.0 patent application document disclosed in a kind of Guyang the kidney invigorating the meridian dredging ferment and preparation method thereof；This kind of Guyang
The composition of the kidney invigorating the meridian dredging ferment is: Fructus Lycii 10%, Fructus Jujubae 10%, Herba Epimedii 7%, the Rhizoma Atractylodis Macrocephalae 2%, Herba polygoni hydropiperis 35%, Fructus Colocasiae Esculentae perfume
Rice 20%, black glutinous rice 25%；Form through three grade fermemtation via fermentative microflora, there is nourishing the liver and kidney, unobstructed grain, tonification human body essence
The effect of gas.But, this ferment composition is simple, and functional the best, ferment product is fruit and vegerable fermentation liquid, and fluid product is unfavorable for taking
Band transports.
Inadequate to the concern of mouthfeel, quality and the dosage form of ferment finished product for present stage, applicant feels the need to into one
The Exploitative potential of step exploitation ferment, to obtain the ferment based food that mouthfeel is adjustable controlled and is convenient for carrying.
Summary of the invention
Present invention seek to address that technical problem present in prior art.To this end, it is an object of the invention to propose one
Having the enzyme composition of kidney-reinforcing Yang strengthening effect, probiotic bacteria and functional oligose are used in combination by this enzyme composition, and
Add Chinese medicine ingredients, make said composition while having good intestinal microbial population regulatory function, it is possible to promote small molecular sugar and
Polysaccharide is to the conversion of oligosaccharide；Give full play to the Chinese medicine extract kidney-reinforcing Yang strengthening of enzyme composition, effect of benefit essence QI invigorating.
Technical scheme is as follows:
A kind of enzyme composition with kidney-reinforcing Yang strengthening effect, this enzyme composition includes following component: probiotic bacteria 1-15
Weight portion, plant enzyme stock solution 10-120 weight portion and Chinese medicine extract 10-80 weight portion；Described enzyme composition is that Chinese medicine carries
Mix with plant enzyme stock solution after taking the sterilized technique of thing, and inoculate beneficial flora and carry out sealed fermenting and form；
Described Chinese medicine extract is extracted by following bulk drugs and forms: Rhizoma Dioscoreae 2-10 weight portion, Stichopus japonicus 2-10 weight portion, Gaster caprae seu Ovis
Bacterium 1-8 weight portion, Rhizoma Imperatae 2-10 weight portion, Quinoa 2-8 weight portion, Radix seu Fructus Rosae Sericeae 1-8 weight portion, Hippocampus 0.5-6 weight portion, celestial being
Thatch 0.5-6 weight portion, Medulla Helianthi 0.2-3 weight portion, Fructus Jujubae 0.5-6 weight portion and Radix Notoginseng 0.5-5 weight portion.
Probiotic bacteria coordinates fermentation with plant enzyme stock solution, can activate the effective efficiency composition in fruit and vegerable, dissolution more elite
Activity effect material.Use with Chinese medicine extract reasonable combination simultaneously so that it is and have between probiotics fermention thing and mutually promote
Effect, it is possible to the multiplication regulatory function to intestinal microbial population, improves the absorption to Effective Component of Chinese Medicine, realizes kidney tonifying further and strengthens
Sun, effect of vigorate qi and replenish the blood.Additionally, the plant enzyme stock solution added is carried out primary sending out by fruit and vegerable impregnation liquid inoculation beer yeast
Ferment technique, improves enzyme composition of the present invention from fermentability, is that in enzyme composition, each effective ingredient can obtain more abundant
Release.
Further reasonable disposition, described plant enzyme stock solution by after fruit and vegerable impregnation liquid inoculation beer yeast in temperature is
In the hermetic container of 30-40 DEG C ferment 2-5d and obtain；Wherein beer yeast inoculum concentration is the 7-10% of fruit and vegerable stock solution weight；Specifically
Described fruit and vegerable impregnation liquid adds enzyme activity and is the cellulase of 400,000 U/g or the pectase of 60,000 U/g carries out enzymolysis, with white sugar and
Pure water mixing is made through ozone sterilization after standing 24h, and the ratio of weight and number of described fruit and vegetable materials, white sugar and water is 3-4:1:6,
Described fruit and vegetable materials is Fructus Mangifera Indicae and Fructus Vitis viniferae.The required timeliness of fruit and vegerable impregnation liquid fermentation prepared by the method is short, shortens the production time.
Further, described probiotic bacteria is probiotic bacteria powder, following at least two powder be uniformly mixed: bifid bar
Bacterium 1.5-3 weight portion, lactobacillus rhamnosus 2-2.5 weight portion, lactobacillus casei 1.2-2 weight portion, bacillus acidophilus 1.4-2.5
Weight portion and Lactobacillus plantarum 2-3 weight portion, the viable bacteria content of described probiotic bacteria powder is 1 × 108-5×108cfu/g。
The functional oligose added in enzyme composition of the present invention is growth of probiotics substrate, has and promotes probiotic bacteria
The physiological function of propagation, the further multiplication regulatory function to intestinal microbial population, thus effect based on intestinal microbial population plays more preferably
Enhancing immunity；In concrete scheme, described enzyme composition also includes oligomeric galactose 10-50 weight portion, arabinose
5-30 weight portion and vitamin B group's 12-35 weight portion.
Wherein preferably in scheme, described enzyme composition includes following component: probiotic bacteria 12.5 weight portion, plant enzyme
Stock solution 86 weight portion, Chinese medicine extract 40.7 weight portion, oligomeric galactose 26 weight portion, arabinose 18 weight portion and dimension are raw
Element B group 22.5 weight portion；Wherein, described Chinese medicine extract is extracted by following crude drug and forms: Rhizoma Dioscoreae 5.8 weight portion, Stichopus japonicus
4.5 weight portions, Morchella esculenta (L.) Pers 5 weight portion, Rhizoma Imperatae 4.5 weight portion, Quinoa 3.2 weight portion, Radix seu Fructus Rosae Sericeae 4 weight portion, hippocampus 3 .5 weight
Amount part, Rhizoma Curculiginis 3.5 weight portion, Medulla Helianthi 1.5 weight portion, Fructus Jujubae 3.2 weight portion and Radix Notoginseng 2 weight portion.
For improving property easy to use and the storage time limit of enzyme composition, present invention also offers one and there is kidney-reinforcing Yang strengthening
The effervescent tablet of effect, effervescent tablet is made up of above-mentioned enzyme composition and adjuvant, and the ratio of weight and number of described compositions and adjuvant is
1:0.5-1:3。
Wherein, described adjuvant includes maltodextrin 35-80 weight portion, sodium bicarbonate 60-132 weight portion, citric acid 35-80
Weight portion, sodium starch phosphate 10-40 weight portion, acesulfame potassium 30-60 weight portion, colloidality silica 1 6-52 weight portion
And zinc stearate 10-30 weight portion.By being used in conjunction with of maltodextrin and sodium starch phosphate, enzyme composition can be improved
Availability, assists compositions or strengthens compositions effect, improving compositions curative effect；Being total to of two colloidality silicon dioxide and zinc stearate
Improve the cohesive force between compositions further with using, improve tablet molding.
Design learns, in effervescent tablet of the present invention during the following scheme of each proportioning raw materials, have kidney-reinforcing Yang strengthening and most preferably treat after deliberation
Effect, and effervescent tablet stability, molding and bioavailability are the most optimal.Concrete, effervescent tablet is by following enzyme composition and adjuvant
Processed it is prepared from:
Enzyme composition: 187.7 weight portions；
Adjuvant: maltodextrin 64 weight portion, sodium bicarbonate 118 weight portion, citric acid 45 weight portion, sodium starch phosphate 28 weight
Amount part, acesulfame potassium 51 weight portion, colloidality silicon dioxide 34 weight portion and zinc stearate 20 weight portion.
It is a further object to provide the preparation method of a kind of above-mentioned enzyme composition, described method includes following
Step:
(1) preparation of Chinese medicine extract:
(1.1) weighing the Stichopus japonicus of recipe quantity, Morchella esculenta (L.) Pers and Hippocampus, boiling three times, amount of water is this four taste for the first time
8 times of Chinese medicine gross weight, decoct 3h；Amount of water is 5 times of this four tastes Chinese medicine gross weight for the second time, decocts 2h；Amount of water is for the third time
3 times of this four tastes Chinese medicine gross weight, decoct 1h；Merging decoction liquor, filter, filtrate is concentrated into the leaching that relative density is 1.20-1.25
Cream, dissolves with 1 times amount 50% ethanol water, upper macroporous adsorptive resins, first washes with water, discard eluent, then use 10%-
15% ethanol aqueous wash, to close to colourless, discards eluent, then with 20 column volumes of 50%-70% ethanol water eluting,
Collect eluent, concentrate, obtained solution 1；
(1.2) Rhizoma Dioscoreae of recipe quantity, Rhizoma Imperatae, Quinoa, Radix seu Fructus Rosae Sericeae, Rhizoma Curculiginis, Medulla Helianthi, Fructus Jujubae and Radix Notoginseng are weighed,
Boiling twice, each 1h；Amount of water is add raw material gross weight 10 times for the first time；Amount of water is total for adding raw material for the second time
8 times of weight；Merge decoction liquor, filter, obtain solution 2；
(1.3) solution 2 mix homogeneously that the solution 1 step (1.1) prepared and step (1.2) prepare, obtains Chinese medicine extraction
Thing；
(2) preparation of plant enzyme stock solution: fruit and vegetable materials adds cellulase or 60,000 U/g that enzyme activity is 400,000 U/g
After pectase carries out enzymolysis, white sugar is added in fruit and vegetable materials, be simultaneously introduced pure water mix homogeneously, after standing extraction 24h,
Carry out ozone sterilization, filter, obtain planting dip；Fruit and vegerable impregnation liquid is inoculated into the beer yeast that inoculum concentration is 8%, in temperature
For the 3d that ferments in the hermetic container of 30-40 DEG C, obtain plant enzyme stock solution；
(3) Chinese medicine extract and plant enzyme stock solution are mixed, add probiotic bacteria, oligomeric galactose, arabinose and dimension
Raw element B group, ferment in the hermetic container that temperature is 30-40 DEG C 5-7d, filters, collects filtrate, and filtrate carries out cold nebulization and does
Dry, obtain the enzyme composition of powdery.
The raw material of Chinese medicine extracted by above-mentioned steps, the extraction ratio of Effective Component of Chinese Medicine is high.Prepared by above-mentioned steps
Enzyme composition, improves directly interpolation probiotic bacteria and prepares the traditional handicraft of plant enzyme, and enzyme composition self has doctor
Nutritional labeling splendid in curative effect on and dietetic therapy；It also offers a kind of brand-new enzyme preparation, combined by this ferment
Thing is prepared as various preparation, it is simple to carries and eats.
In preparation prepared by enzyme composition of the present invention, being preferably prepared into effervescent tablet, being directly dissolved in water can use,
And rate of dissolution is very fast, need not be by the most available sufficiently release of mixing plant effective ingredient in the effective process time.Tool
The preparation method of body is as follows:
A. prepare the enzyme composition of powdery, weigh formula ratio and cross 60 mesh sieves, stand-by；
B. the maltodextrin and the sodium starch phosphate that weigh formula ratio put into baking oven, dry 3h, after cooling under the conditions of 60 DEG C
Cross 60 mesh sieves, stand-by；
C. weigh the sodium bicarbonate of formula ratio, dissolve with the ethanol solution of 60-80%, add the step a process of 1/2 weight
Enzyme composition and the maltodextrin that processes of step b of 1/2 weight and sodium starch phosphate, make soft material, wet granulation, low
Temperature is dried, and granulate obtains bicarbonate soda granule；
D. the citric acid weighing formula ratio is mixed homogeneously with acesulfame potassium, dissolves with the ethanol solution of 60-80%, adds
Enter the enzyme composition of the step a process of 1/2 weight and the maltodextrin of the step b process of 1/2 weight and sodium starch phosphate,
Make soft material, wet granulation, cold drying, granulate, obtain granulates；
Granulates mixing prepared by the bicarbonate soda granule e. step c prepared and step d, adds colloidality titanium dioxide
Silicon and zinc stearate uniformly mix, tabletting, prepare effervescent tablet.
The Chinese medicinal components added in the enzyme composition of the present invention has its physiologically active and health-care effect, is prebiotic simultaneously
Bacterium supplements the nutrients in fermentation, has higher practical value, and the Chinese medicine ingredients of the present invention can effectively kidney-reinforcing Yang strengthening, QI invigorating be mended
Blood；Between probiotic bacteria, functional oligose, vitamin B group and each component of Chinese medicine, compatibility is reasonable, and clear curative effect has collaborative
The effect of potentiation.
This ferment effervescent tablet is convenient for carrying, and wherein retains the Chinese medicine extract effective ingredient with kidney-reinforcing Yang strengthening, also retains
Ferment polyphenol, and coordinate oligosaccharide to use the contents of saccharide reduced in ferment, improve products taste, and can adjust as required
Joint；Effervescent tablet preparation formulation further improves the stability of ferment polyphenol.This enzyme composition and effervescent tablet thereof are suitably suffered from a deficiency of the kidney gas
The people lost uses, and takes as daily beverage, improves internal metabolism from the angle effected a permanent cure, and improves body immunity etc. simultaneously, real
The purpose now kept healthy.
Additionally, the technical process that plant enzyme solid preparation is prepared in enzyme composition directly interpolation is simple, it is easy to accomplish big
Large-scale production, and safe preparation process, have good application prospect.
The source of the raw material of Chinese medicine composition of the present invention:
Rhizoma Dioscoreae: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb..
Stichopus japonicus: for Stichopodidae animal Radix Morinae Bulleyanae, Stichopus chloronotus (Brandt)., the entirety of change Radix Morinae Bulleyanae.
Morchella esculenta (L.) Pers: for Morchellaceae fungus Morchella esculenta (L.) Pers, little top Morchella esculenta (L.) Pers, Morchellaconica, Morchella crassipes, little Morchella esculenta (L.) Pers
Deng sporophore.
Rhizoma Imperatae: this product is grass Herba Imperatae Imperata cylindrica Beauv.var.major (Nees)
C.E.Hubb. dry rhizome.
Quinoa: Quinoa plant classification belongs to Chenopodiaceae, dicotyledon；Original producton location be distributed mainly on South America Bolivia,
Ecuador and Peru.
Radix seu Fructus Rosae Sericeae: Rosaceae Radix seu Fructus Rosae Sericeae Rosa sericea Lindl., with root, fruit medicine.
Hippocampus: this product is Syngnathidae animal strain line Hippocampus Hippocampus kelloggi Jordan et Snyder, thorn
Hippocampus Hippocampus histrix Kaup, Hippocampus Kuda Hippocampus kuda Bleeker, hippocampus trimaculatus Leacs
Hippocampus trimaculatus Leach or little Hippocampus (HAIQU) Hippocampus japonicus Kaup is dried
Body.
Rhizoma Curculiginis: this product is the dry rhizome of amrallid Rhizoma Curculiginis Curculigo orchioides Gaertn..Autumn, winter
Two seasons excavated, and removed root head and fibrous root, cleaning, drying.
Medulla Helianthi: for the stem pith of feverfew Helianthi, phytomorph detailed Semen Helianthi bar.
Fructus Jujubae: this product is Rhamnaceae jujube Fructus Jujubae Ziziphus jujuba Mill.var.inermis (Bunge)
Rehd. dry mature fruit
Radix Notoginseng: this product is the dry root of panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen.
Detailed description of the invention
Embodiment 1 enzyme composition
The prescription of the enzyme composition of the present embodiment is:
Probiotic bacteria 40g, plant enzyme stock solution 100g, Chinese medicine extract 100g；
Wherein, probiotic bacteria is made up of following probiotic bacteria powder: bacillus bifidus 15g, lactobacillus rhamnosus 25g；
Plant enzyme stock solution is prepared from by following raw material: Fructus Mangifera Indicae 20g, Fructus Vitis viniferae 10g, dimension element enzyme 400,000 U/g, white sugar 10g,
Pure water 60g, beer yeast 7g；
Chinese medicine extract is prepared from by following raw material: Rhizoma Dioscoreae 40g, Stichopus japonicus 40g, Morchella esculenta (L.) Pers 20g, Rhizoma Imperatae 40g, Quinoa
40g, Radix seu Fructus Rosae Sericeae 20g, Hippocampus 10g, Rhizoma Curculiginis 10g, Medulla Helianthi 4g, Fructus Jujubae 10g, Radix Notoginseng 10g.
Wherein, plant enzyme stock solution preparation method is: select maturation, without the Fructus Mangifera Indicae rotted and Fructus Vitis viniferae, and Fructus Mangifera Indicae is peeled stripping and slicing, Fructus Vitis viniferae
Cutting, add the cellulase that enzyme activity is 400,000 U/g and carry out enzymolysis, enzyme addition is the 0.05% of plant material；After enzymolysis
Addition white sugar and pure water, mix homogeneously, after standing 24h, ozone sterilization, prepare plant extraction liquid；Inoculation beer yeast is to planting
Thing extracting solution, ferment in the hermetic container of temperature 30-40 DEG C 2d, obtains plant enzyme stock solution.
Embodiment 2 enzyme composition
The prescription of the enzyme composition of the present embodiment is:
Probiotic bacteria 150g, plant enzyme stock solution 1200g, Chinese medicine extract 800g；
Wherein, probiotic bacteria is made up of following probiotic bacteria powder: lactobacillus rhamnosus 50g, lactobacillus casei 100g；
Plant enzyme stock solution is prepared from by following raw material: Fructus Mangifera Indicae 300g, Fructus Vitis viniferae 133g, pectase 60,000 U/g, white sugar
108g, pure water 650g, beer yeast 119g；
Chinese medicine extract is prepared from by following raw material: Rhizoma Dioscoreae 200g, Stichopus japonicus 200g, Morchella esculenta (L.) Pers 160g, Rhizoma Imperatae 200g,
Quinoa 160g, Radix seu Fructus Rosae Sericeae 160g, Hippocampus 120g, Rhizoma Curculiginis 120g, Medulla Helianthi 60g, Fructus Jujubae 120g, Radix Notoginseng 100g.
Wherein, plant enzyme stock solution preparation method is: select maturation, without the Fructus Mangifera Indicae rotted and Fructus Vitis viniferae, and Fructus Mangifera Indicae is peeled stripping and slicing, Fructus Vitis viniferae
Being cut in half, add the cellulase that enzyme activity is 60,000 U/g and carry out enzymolysis, enzyme addition is the 0.02% of plant material；Enzymolysis
Rear addition white sugar and pure water, mix homogeneously, after standing 24h, ozone sterilization, prepare plant extraction liquid；Inoculation beer yeast is extremely
Plant extraction liquid, ferment in the hermetic container of temperature 30-40 DEG C 5d, obtains plant enzyme stock solution.
Embodiment 3 enzyme composition
The prescription of the enzyme composition of the present embodiment is:
Probiotic bacteria 125g, plant enzyme stock solution 860g, Chinese medicine extract 407g, oligomeric galactose 260g, arabinose
180g and vitamin B group 225g；
Wherein, probiotic bacteria is made up of following probiotic powder: bacillus bifidus 50g, lactobacillus casei 50g, Lactobacillus plantarum
25g；
Plant enzyme stock solution is prepared from by following raw material: Fructus Mangifera Indicae 225g, Fructus Vitis viniferae 225g, cellulase 400,000 U/g, white sugar
150g, pure water 900g, beer yeast 115g；
Described Chinese medicine extract is extracted by following crude drug and forms: Rhizoma Dioscoreae 116g, Stichopus japonicus 90g, Morchella esculenta (L.) Pers 100g, Rhizoma Imperatae
90g, Quinoa 64g, Radix seu Fructus Rosae Sericeae 80g, Hippocampus 70g, Rhizoma Curculiginis 70g, Medulla Helianthi 30g, Fructus Jujubae 64g and Radix Notoginseng 40g；
Preparation method:
(1) preparation of Chinese medicine extract:
(1.1) weighing the Stichopus japonicus of recipe quantity, Morchella esculenta (L.) Pers and Hippocampus, boiling three times, amount of water is this four taste for the first time
8 times of Chinese medicine gross weight, decoct 3h；Amount of water is 5 times of this four tastes Chinese medicine gross weight for the second time, decocts 2h；Amount of water is for the third time
3 times of this four tastes Chinese medicine gross weight, decoct 1h；Merging decoction liquor, filter, filtrate is concentrated into the leaching that relative density is 1.20-1.25
Cream, dissolves with 1 times amount 50% ethanol water, upper macroporous adsorptive resins, first washes with water, discard eluent, then use 10%-
15% ethanol aqueous wash, to close to colourless, discards eluent, then with 20 cylinders of 50%-70% ethanol water eluting
Long-pending, collect eluent, concentrate, obtained solution 1；
(1.2) Rhizoma Dioscoreae of recipe quantity, Rhizoma Imperatae, Quinoa, Radix seu Fructus Rosae Sericeae, Rhizoma Curculiginis, Medulla Helianthi, Fructus Jujubae and Radix Notoginseng are weighed,
Boiling twice, each 1h；Amount of water is add raw material gross weight 10 times for the first time；Amount of water is total for adding raw material for the second time
8 times of weight；Merge decoction liquor, filter, obtain solution 2；
(1.3) solution 2 mix homogeneously that the solution 1 step (1.1) prepared and step (1.2) prepare, obtains Chinese medicine extraction
Thing, takes 407g standby；
(4) preparation of plant enzyme stock solution: select maturation, without the Fructus Mangifera Indicae rotted and Fructus Vitis viniferae, Fructus Mangifera Indicae is peeled stripping and slicing, and Fructus Vitis viniferae is cut
Sheet, adds the cellulase that enzyme activity is 400,000 U/g and carries out enzymolysis, and enzyme addition is the 0.05% of plant material；Add after enzymolysis
Enter white sugar and pure water, mix homogeneously, after standing 24h, ozone sterilization, prepare plant extraction liquid；Inoculation beer yeast is to plant
Extracting solution, ferment in the hermetic container of temperature 30-40 DEG C 4d, obtains plant enzyme stock solution, takes 860g standby；
(5) Chinese medicine extract and plant enzyme stock solution are mixed, add probiotic bacteria, oligomeric galactose, arabinose and dimension
Raw element B group, ferment in the hermetic container that temperature is 30-40 DEG C 5-7d, filters, collects filtrate, and filtrate carries out cold nebulization and does
Dry, obtain the enzyme composition of powdery.
Embodiment 4 enzyme composition
The prescription of the enzyme composition of the present embodiment is:
Probiotic bacteria 20g, plant enzyme stock solution 450g, Chinese medicine extract 200g, oligomeric galactose 500g, arabinose 50g
And vitamin B group 120g；
Wherein, probiotic bacteria is made up of following probiotic powder: bacillus bifidus 8g, lactobacillus rhamnosus 7g, bacillus acidophilus
5g；
Plant enzyme stock solution is prepared from by following raw material: Fructus Mangifera Indicae 80g, Fructus Vitis viniferae 55g, cellulase 400,000 U/g, white sugar
45g, pure water 270g, beer yeast 40g；
Described Chinese medicine extract is extracted by following crude drug and forms: Rhizoma Dioscoreae 70g, Stichopus japonicus 60g, Morchella esculenta (L.) Pers 40g, Rhizoma Imperatae
50g, Quinoa 50g, Radix seu Fructus Rosae Sericeae 40g, Hippocampus 20g, Rhizoma Curculiginis 20g, Medulla Helianthi 10g, Fructus Jujubae 20g and Radix Notoginseng 20g.
Preparation method: prepare according to the method for embodiment 3.
Embodiment 5 effervescent tablet
Use the enzyme composition of embodiment 3: 1877g；
Adjuvant: maltodextrin 640g, sodium bicarbonate 1180g, citric acid 450g, sodium starch phosphate 280g, acesulfame
Potassium 510g, colloidality silicon dioxide 340g and zinc stearate 200g.Preparation method comprises the steps:
A. prepare the enzyme composition of powdery, weigh formula ratio and cross 60 mesh sieves, stand-by；
B. the maltodextrin and the sodium starch phosphate that weigh formula ratio put into baking oven, dry 3h, after cooling under the conditions of 60 DEG C
Cross 60 mesh sieves, stand-by；
C. weigh the sodium bicarbonate of formula ratio, dissolve with the ethanol solution of 60-80%, add the step a process of 1/2 weight
Enzyme composition and the maltodextrin that processes of step b of 1/2 weight and sodium starch phosphate, make soft material, wet granulation, low
Temperature is dried, and granulate obtains bicarbonate soda granule；
D. the citric acid weighing formula ratio is mixed homogeneously with acesulfame potassium, dissolves with the ethanol solution of 60-80%, adds
Enter the enzyme composition of the step a process of 1/2 weight and the maltodextrin of the step b process of 1/2 weight and sodium starch phosphate,
Make soft material, wet granulation, cold drying, granulate, obtain granulates；
Granulates mixing prepared by the bicarbonate soda granule e. step c prepared and step d, adds colloidality silicon dioxide
Uniformly mix with zinc stearate, tabletting, prepare effervescent tablet.
Embodiment 6 effervescent tablet
Use the enzyme composition of embodiment 4: 1910g；
Adjuvant: maltodextrin 350g, sodium bicarbonate 600g, citric acid 350g, sodium starch phosphate 100g, acesulfame potassium
300g, colloidality silica 1 60g and zinc stearate 100g.
Preparation method: prepare according to preparation method described in embodiment 5.
Embodiment 7 effervescent tablet
Use the enzyme composition of embodiment 3: 2600g；
Adjuvant: maltodextrin 800g, sodium bicarbonate 1320g, citric acid 800g, sodium starch phosphate 400g, acesulfame
Potassium 600g, colloidality silicon dioxide 520g and zinc stearate 300g.
Preparation method: prepare according to preparation method described in embodiment 5.
Embodiment 8 effervescent tablet
Use the enzyme composition of embodiment 3: 4715g；
Adjuvant: maltodextrin 780g, sodium bicarbonate 1220g, citric acid 800g.
Preparation method comprises the steps:
A. prepare the enzyme composition of powdery, weigh formula ratio and cross 60 mesh sieves, stand-by；
B. baking oven put into by the maltodextrin weighing formula ratio, dries 3h under the conditions of 60 DEG C, crosses 60 mesh sieves, treat after cooling
With；
C. weigh the sodium bicarbonate of formula ratio, dissolve with the ethanol solution of 60-80%, add the step a process of 1/2 weight
Enzyme composition and the maltodextrin that processes of step b of 1/2 weight, make soft material, wet granulation, be dried, granulate,
To bicarbonate soda granule；
The ethanol solution of the citric acid 60-80% d. weighing formula ratio dissolves, and adds the step a process of 1/2 weight
The maltodextrin that step b of enzyme composition and 1/2 weight processes, makes soft material, wet granulation, is dried, granulate, obtains acid
Granule；
Granulates prepared by the bicarbonate soda granule f. step c prepared and step d uniformly mixes, tabletting, prepares bubble
Rise sheet.
Comparative examples 1
Use the enzyme composition of embodiment 3: 1877g；
Adjuvant: maltodextrin 640g, sodium bicarbonate 1180g, citric acid 450g, acesulfame potassium 510g, colloidality dioxy
SiClx 340g and zinc stearate 200g.
Preparation method: in addition to being not added with sodium starch phosphate, all prepares according to preparation method described in embodiment 5.
Comparative examples 2
Use the enzyme composition of embodiment 3: 1877g；
Adjuvant: maltodextrin 640g, sodium bicarbonate 1180g, citric acid 450g, sodium starch phosphate 280g, colloidality titanium dioxide
Silicon 340g and zinc stearate 200g.
Preparation method: in addition to being not added with acesulfame potassium, all prepares according to preparation method described in embodiment 5.
Comparative examples 3
Use the enzyme composition 1877g of embodiment 3；
Adjuvant: identical with adjuvant described in embodiment 5 and consumption thereof.
Preparation method comprises the steps:
A. prepare the enzyme composition of powdery, weigh formula ratio and cross 60 mesh sieves, stand-by；
B. the maltodextrin and the sodium starch phosphate that weigh formula ratio put into baking oven, dry 3h, after cooling under the conditions of 60 DEG C
Cross 60 mesh sieves, stand-by；
C. weigh the sodium bicarbonate of formula ratio, add enzyme composition and formula ratio Fructus Hordei Germinatus that formula ratio step a processes
Dextrin and sodium starch phosphate, mix homogeneously, it is dried, granulate, obtains bicarbonate soda granule；
D. the citric acid weighing formula ratio is mixed homogeneously with acesulfame potassium, is dried, granulate, obtains granulates；
Granulates mixing prepared by the bicarbonate soda granule g. step c prepared and step d, adds colloidality silicon dioxide
Uniformly mix with zinc stearate, tabletting, prepare effervescent tablet.
Test example 1 mouthfeel is tested
The sample 10g of Example 3, embodiment 5 and matched group embodiment 2 so that it is be dissolved in the water of 200ml, stirring, system
Obtain need testing solution；Allow 10 professional test persons taste need testing solution, compare and take rear mouthfeel；Standards of grading divide 4 grades,
Mouthfeel is poor, with bitter taste, and 1 point；Mouthfeel is poor, with slight bitter taste 2 points；Good in taste, without bitter taste, 3 points；Mouthful
Feeling, taste is sweet, without bitter taste 4 points；Test result is shown in Table 1；
The sensory test result of table 1 enzyme composition and effervescent tablet
From table 1 it follows that the sweeting agent of the embodiment of the present invention 5 formula proportion adds the mouth preferably improving effervescent tablet
Sense, reduces the bitter taste of medicine；Can draw from the result of embodiment 3 with comparative examples 2, the enzyme composition mouth of the present invention
Though sense is good not as embodiment 5, but mouthfeel still accepts for people.
Test example 2 stability test
1. accelerated test
Example 5 and the effervescent tablet of comparative examples 1, select 3 batches and test, and the sample number into spectrum of embodiment 5 is sample
1, sample 2 and sample 3；The sample number into spectrum of comparative examples 1 is sample 4, sample 5, sample 6；In temperature40℃±2℃Under, phase
To humidity it is75% ± 5%Under conditions of place 6 months, testing 1 month period, 2 months, 3 months, 6 the end of month take respectively
Sample once, by the regulation in Chinese Pharmacopoeia, detects the character of effervescent tablet, the content (labelled amount %) of curculigoside, it was found that
The effervescent tablet indices of embodiment 5 has no significant change, and the effervescent tablet of comparative examples 1 tablet surface when 3 months is thicker
Rough, fragment occurs, when 6 months, effervescent tablet has sliver.Understanding, the interpolation of sodium starch phosphate is favorably improved stablizing of effervescent tablet
Property.
2. long term test
Example 5, the effervescent tablet of comparative examples 1, select 3 batches and test, embodiment 5 numbered sample 1 respectively,
Sample 2 and sample 3；Comparative examples 5 numbered sample 4, sample 5 and sample 6 respectively are in temperature25℃±2℃Under, the wettest
Degree is60% ± 10%Under conditions of place 24 months, test 0 month period, 3 months, 6 months, 9 months, 12 months, 18
Individual month, 24 the end of month separately sampled once, by the regulation in Chinese Pharmacopoeia, detect the character of effervescent tablet of embodiment 5, celestial being
The content (labelled amount %) of thatch glycosides, it was found that indices has no significant change；The effervescent tablet of comparative examples 1 was at 3 months
Time tablet surface roughening, fragment occurs, when 6 months, effervescent tablet has sliver.Understanding, the interpolation of sodium starch phosphate is favorably improved
The stability of effervescent tablet.
Test example 3 slaking test
With reference to the regulation of Effervescent tablet disintegration test under 2010 editions annex of Chinese Pharmacopoeia, the embodiment of the present invention 5 effervescent tablet is entered
Row disintegrative detects, and detection method is as follows:
Example 5 effervescent tablet 12 is for for examination group, and comparative examples 3 effervescent tablet 12 is matched group, and every weight is equal
For 3g, add normal-temperature water 200ml, stand 30min.Result of the test is；
For examination group: the complete disintegrate in about 3.5min in normal-temperature water of all effervescent tableies, solution clarification (show to dissolve
Completely), without muddy, taste fragrance.
Matched group: effervescent tablet needs disintegrate completely in 5-10min, slightly cloudy, taste fragrance.
More than test shows, effervescent tablet preparation method of the present invention is mixed by substep, the preparation of mixing after substep soft material processed
Effervescent tablet disintegration prepared by method is better, dissolution can discharge the property of medicine rapidly, has taking convenience, dissolution rapid release spy
Property, reach intended galenic pharmacy effect.
Embodiment 4 zoology test
1, test specimen: the enzyme composition of embodiment 3 preparation
2, animal: Kunming mouse, SPF level, male, body weight is 18-22gWistar rat, and SPF level is male, body weight
200-250g。
3, experimental technique
3.1 enzyme compositions are on castration male mice preputial glands, seminal fluid capsule and prostatic impact
Taking male mice 40, be randomly divided into 4 groups, often group 10, is respectively as follows: normal group, model group, enzyme composition
High, medium and low dosage group, in addition to normal group, makes potential model for other 3 groups, the chloral hydrate anesthesia of 5%, excision both sides testis.
For preventing from infecting, postoperative intramuscular injection penicillin sodium 20,000 U/kg.Postoperative 3d, the other gavage of high, medium and low dosage component give 10g/kg,
5g/kg, 2.5g/kg enzyme composition, normal group, model group only gavage the distilled water of same volume, successive administration 20d.21d,
Put to death animal, cut preputial glands, seminal fluid capsule and prostate, Ex-all peripheral adipose, claim its weight in wet base (mg), calculate its organ index,
Wherein organ index=internal organs weight (mg)/body weight (g).
The impact on castrated rats erection of 3.2 enzyme compositions
By Wistar male rat 40, it is randomly divided into 5 groups, often group 8, i.e. normal group, kidney-yang deficiency model group, ferment group
Compound high, medium and low dosage group, in addition to normal group, makes potential model for other 4 groups, chloral hydrate (0.5ml/100g) fiber crops of 5%
Liquor-saturated descending bilateral orchidectomy, postoperative muscle injection penicillin 40,000 U, injection 3d is with infection continuously.Test high, medium and low dose
Amount group gavage respectively gives 10g/kg, 5g/kg, 2.5g/kg enzyme composition, and normal group, model group only gavage the steaming of same volume
Distilled water, 1h after being administered in last 1 time, the stimulating electrode of electric stimulating instrument is placed in rat penis position, and (electrode is put in outside urethra
Mouthful, another electrode is placed in radix penis part), dip in normal saline with cotton swab and moisten rat radix penis part, to strengthen its electric conductivity.Give
Local electrical stimulation, voltage 6V, frequency 20Hz, ripple width 5ms, with stopwatch record from stimulating beginning (to erect latent to the erection time
The volt phase).
4, experimental result
Table 2 enzyme composition is on castration male mice preputial glands, seminal fluid capsule and prostatic impact
Note: ▲ ▲ compared with normal group P < 0.01, * * P < 0.01 compared with model group
The impact on castrated rats penile erectile function of table 3 enzyme composition
Note: ▲ compared with normal group P < 0.05, * P < 0.05 compared with model group
5, analyze
As shown in Table 2, model group is compared with normal group, and model group mouse preputial gland, seminal fluid capsule and prostatic weight are equal
Reducing, have statistical significance, modeling success is described, it is male that enzyme composition experimental group all can increase castration compared with normal group
Mouse preputial gland, seminal fluid capsule and prostatic weight, improve organ index, owing to testis is the organ of secretion androgen, and profit
Removing animal testis with castrating causes androgen secretion to lack, if medicine has Andrin-like action, then can maintain with raw
Grow relevant glandular development, will not atrophy loss of weight, point out enzyme composition of the present invention have androgen support effect, there is tonifying YANG
Effect.
Castrated rats animal pattern group is compared with Normal group as shown in Table 3, model group rats eclipse period of penile erection
Notable prolongation illustrates modeling success, and application castration male rat is tested, and with electric stimulus inducing erection, observes ferment group
Compound, on preclinical impact of erecing, can determine whether its yang invigorating functions, and Stichopus japonicus Chinese medicine extraction liquid each dosage group all can be to some extent
Shorten castrated rats eclipse period of penile erection, improve the castrated rats penis irritability to outside stimulus, show that having kidney tonifying strengthens
Sun effect.
Model case
Case 1: Wang, man, 28 years old, suffers from sexual impotence half a year, it is impossible to cross normal sexuality, and has premature ejaculation, seminal emission, the soreness of waist weak
Deng disease.Taking the embodiment of the present invention 5 effervescent tablet, 3 times on the one, after taking 30 days, penis can be lifted, and can live by Progressive symmetric erythrokeratodermia, and the soreness of waist is weak
Phenomenon makes moderate progress, and takes recovery from illness in June, transference cure, and sexual life recovers normal.
Case 2: Lee, man, 46 years old, frequent micturition, limbs fatigue, cold-damp of suffering from a deficiency of the kidney, asthma, lassitude loin and legs, absent minded.
Take the embodiment of the present invention 3 enzyme composition, each take 6g, 3 times on the one, warm water delivery service, after taking 10 days, evening urine
Number of times reduces, and myasthenia of limbs sense alleviates, and continues to take 10 days, and urine of the most not getting up evening, lassitude loin and legs's phenomenon alleviates, and notes
Power intensity increases, and takes recovery from illness in 32 days.
Case 3: Lin, man 41 years old, frequent micturition, suffer from a deficiency of the kidney, the symptom such as have premature ejaculation, the soreness of waist weak.Take the embodiment of the present invention 5 to steep
Rising sheet, 3 times on the one, after taking 15 days, penis can be lifted, can, the weak phenomenon of the soreness of waist makes moderate progress, and premature ejaculation phenomenon is improved；Take 3
Moon recovery from illness, transference cure.
Claims (10)
1. an enzyme composition with kidney-reinforcing Yang strengthening effect, it is characterised in that this enzyme composition includes following component: benefit
Raw bacterium 1-15 weight portion, plant enzyme stock solution 10-120 weight portion and Chinese medicine extract 10-80 weight portion；Described enzyme composition
For mixing with plant enzyme stock solution after the sterilized technique of Chinese medicine extract, and inoculate beneficial flora and carry out sealed fermenting and form；
Described Chinese medicine extract is extracted by following bulk drugs and forms: Rhizoma Dioscoreae 2-10 weight portion, Stichopus japonicus 2-10 weight portion, Morchella esculenta (L.) Pers 1-
8 weight portions, Rhizoma Imperatae 2-10 weight portion, Quinoa 2-8 weight portion, Radix seu Fructus Rosae Sericeae 1-8 weight portion, Hippocampus 0.5-6 weight portion, Rhizoma Curculiginis
0.5-6 weight portion, Medulla Helianthi 0.2-3 weight portion, Fructus Jujubae 0.5-6 weight portion, Radix Notoginseng 0.5-5 weight portion.
There is the enzyme composition of kidney-reinforcing Yang strengthening effect the most as claimed in claim 1, it is characterised in that described plant enzyme stock solution
Obtained by the 2-5d that ferments in the hermetic container that temperature is 30-40 DEG C after fruit and vegerable impregnation liquid inoculation beer yeast；Wherein medicated beer ferment
Female inoculum concentration is the 7-10% of fruit and vegerable stock solution weight；
Described fruit and vegerable impregnation liquid is added enzyme activity by fruit and vegetable materials and is the cellulase of 400,000 U/g or the pectase of 60,000 U/g is carried out
Enzymolysis, makes through ozone sterilization mix standing 24h with white sugar and pure water after, the weight portion of described fruit and vegetable materials, white sugar and water
Number ratio is 3-4:1:6, and described fruit and vegetable materials is Fructus Mangifera Indicae and Fructus Vitis viniferae.
There is the enzyme composition of kidney-reinforcing Yang strengthening effect the most as claimed in claim 1, it is characterised in that described probiotic bacteria is prebiotic
Bacteria powder, is uniformly mixed by following at least two powder: bacillus bifidus 1.5-3 weight portion, lactobacillus rhamnosus 2-2.5 weight
Amount part, lactobacillus casei 1.2-2 weight portion, bacillus acidophilus's 1.4-2.5 weight portion, Lactobacillus plantarum 2-3 weight portion, described benefit
The viable bacteria content of raw bacteria powder is 1 × 108-5×108cfu/g。
There is the enzyme composition of kidney-reinforcing Yang strengthening effect the most as claimed in claim 1, it is characterised in that described enzyme composition is also
Including oligomeric galactose 10-50 weight portion, arabinose 5-30 weight portion, vitamin B group's 12-35 weight portion.
5. enzyme composition as claimed in claim 4, it is characterised in that described enzyme composition includes following component: prebiotic
Bacterium 12.5 weight portion, plant enzyme stock solution 86 weight portion, Chinese medicine extract 40.7 weight portion, oligomeric galactose 26 weight portion, Ah
Draw uncle sugared 18 weight portions, vitamin B group 22.5 weight portion；
Wherein, described Chinese medicine extract is extracted by following crude drug and forms: Rhizoma Dioscoreae 5.8 weight portion, Stichopus japonicus 4.5 weight portion, Gaster caprae seu Ovis
Bacterium 5 weight portion, Rhizoma Imperatae 4.5 weight portion, Quinoa 3.2 weight portion, Radix seu Fructus Rosae Sericeae 4 weight portion, hippocampus 3 .5 weight portion, Rhizoma Curculiginis 3.5 weight
Amount part, Medulla Helianthi 1.5 weight portion, Fructus Jujubae 3.2 weight portion and Radix Notoginseng 2 weight portion.
6. an effervescent tablet with kidney-reinforcing Yang strengthening effect, it is characterised in that described effervescent tablet is by claim 1 to 5 wherein
Enzyme composition and adjuvant described in one of are made, and the ratio of weight and number of described compositions and adjuvant is 1:0.5-1:3.
7. effervescent tablet as claimed in claim 6, it is characterised in that described adjuvant includes maltodextrin 35-80 weight portion, carbonic acid
Hydrogen sodium 60-132 weight portion, citric acid 35-80 weight portion, sodium starch phosphate 10-40 weight portion, acesulfame potassium 30-60 weight
Amount part, colloidality silica 1 6-52 weight portion and zinc stearate 10-30 weight portion.
8. effervescent tablet as claimed in claim 7, it is characterised in that described effervescent tablet by following enzyme composition and adjuvant through adding
Work is prepared from:
Enzyme composition: 187.7 weight portions；
Adjuvant: maltodextrin 64 weight portion, sodium bicarbonate 118 weight portion, citric acid 45 weight portion, sodium starch phosphate 28 weight
Part, acesulfame potassium 51 weight portion, colloidality silicon dioxide 34 weight portion and zinc stearate 20 weight portion.
9. one kind by the preparation method of the enzyme composition described in claim 4 with kidney-reinforcing Yang strengthening effect, it is characterised in that institute
The method of stating comprises the steps:
(1) preparation of Chinese medicine extract:
(1.1) weighing the Stichopus japonicus of recipe quantity, Morchella esculenta (L.) Pers and Hippocampus, boiling three times, amount of water is this four tastes Chinese medicine for the first time
8 times of gross weight, decoct 3h；Amount of water is 5 times of this four tastes Chinese medicine gross weight for the second time, decocts 2h；For the third time amount of water be this four
3 times of taste Chinese medicine gross weight, decoct 1h；Merging decoction liquor, filter, filtrate is concentrated into the extractum that relative density is 1.20-1.25, uses
1 times amount 50% ethanol water dissolves, and upper macroporous adsorptive resins first washes with water, discards eluent, then use 10%-15% second
Alcohol-water solution is washed, and to close to colourless, discards eluent, then with 20 column volumes of 50%-70% ethanol water eluting, collection is washed
De-liquid, concentrates, obtained solution 1；
(1.2) weigh the Rhizoma Dioscoreae of recipe quantity, Rhizoma Imperatae, Quinoa, Radix seu Fructus Rosae Sericeae, Rhizoma Curculiginis, Medulla Helianthi, Fructus Jujubae and Radix Notoginseng, add water
Decoct twice, each 1h；Amount of water is add raw material gross weight 10 times for the first time；Amount of water is to add raw material gross weight for the second time
8 times；Merge decoction liquor, filter, obtain solution 2；
(1.3) solution 2 mix homogeneously that the solution 1 step (1.1) prepared and step (1.2) prepare, obtains Chinese medicine extract；
(2) preparation of plant enzyme stock solution: fruit and vegetable materials adds cellulase or the pectin of 60,000 U/g that enzyme activity is 400,000 U/g
After enzyme carries out enzymolysis, white sugar is added in fruit and vegetable materials, be simultaneously introduced pure water mix homogeneously, after standing extraction 24h, carry out
Ozone sterilization, filters, obtains planting dip；Fruit and vegerable impregnation liquid is inoculated into the beer yeast that inoculum concentration is 8%, in temperature is
Ferment in the hermetic container of 30-40 DEG C 3d, obtains plant enzyme stock solution；
(3) Chinese medicine extract and plant enzyme stock solution are mixed, add probiotic bacteria, oligomeric galactose, arabinose and vitamin B
Group, ferment in the hermetic container that temperature is 30-40 DEG C 5-7d, filters, collects filtrate, and filtrate carries out low temperature spray drying,
Enzyme composition to powdery.
10. one kind by the preparation method of effervescent tablet described in claim 8, it is characterised in that described method comprises the steps:
A. prepare the enzyme composition of powdery, weigh formula ratio and cross 60 mesh sieves, stand-by；
B. the maltodextrin and the sodium starch phosphate that weigh formula ratio put into baking oven, dry 3h under the conditions of 60 DEG C, cross 60 after cooling
Mesh sieve, stand-by；
C. weigh the sodium bicarbonate of formula ratio, dissolve with the ethanol solution of 60-80%, add the ferment that step a of 1/2 weight processes
The maltodextrin of the step b process of promotor composition and 1/2 weight and sodium starch phosphate, make soft material, wet granulation, and low temperature is done
Dry, granulate, obtain bicarbonate soda granule；
D. the citric acid weighing formula ratio is mixed homogeneously with acesulfame potassium, dissolves with the ethanol solution of 60-80%, adds 1/
Enzyme composition that step a of 2 weight processes and the maltodextrin that step b of 1/2 weight processes and sodium starch phosphate, make
Soft material, wet granulation, cold drying, granulate, obtain granulates；
Granulates mixing prepared by the bicarbonate soda granule e. step c prepared and step d, adds colloidality silicon dioxide with hard
Fat acid zinc uniformly mixes, tabletting, prepares effervescent tablet.
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| CN107048360A (en) * | 2017-04-11 | 2017-08-18 | 姜红成 | Prepare the fermentation composition and preparation method of the plant enzyme with recuperating gastrointestinal tract function of relaxing bowel |
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| CN116173112A (en) * | 2023-02-28 | 2023-05-30 | 江苏新法奥医疗科技有限公司 | Traditional Chinese medicine formula probiotic composition, preparation method and application thereof in improving male sexual function |
| CN116173112B (en) * | 2023-02-28 | 2024-02-02 | 江苏新法奥医疗科技有限公司 | Traditional Chinese medicine formula probiotic composition, preparation method and application thereof in improving male sexual function |
| CN118638687A (en) * | 2024-06-26 | 2024-09-13 | 江苏菌钥生命科技发展有限公司 | Application of Lactobacillus plantarum FTCM001 in the preparation of kidney-tonifying and anti-fatigue products |
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