CN106138246A - A kind of Chinese medicine preparation treating Anchylosis - Google Patents
A kind of Chinese medicine preparation treating Anchylosis Download PDFInfo
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- CN106138246A CN106138246A CN201610628760.6A CN201610628760A CN106138246A CN 106138246 A CN106138246 A CN 106138246A CN 201610628760 A CN201610628760 A CN 201610628760A CN 106138246 A CN106138246 A CN 106138246A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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Abstract
The invention discloses a kind of Chinese medicine fuming-lotion treating Anchylosis, belong to technical field of Chinese medicines.Applicant is for the pathogenesis of Anchylosis, according to the theory of Chinese medical science of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, select Chinese medicine Herba Passiflorae Wilsonii, Radix Pottsiae Laxiflorae, Caulis Chonemorphae Megacalycis, Rhizoma Fagopyri Cymosi, Herba Polygoni Perfoliati, Radix Clinopodii polycephali, make decoction and take for patient, through clinical trial, effective percentage reaches 100%.Especially this Chinese medicine preparation also has preferable therapeutic effect to hypertension.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation treating Anchylosis.
Background technology
Owing to fracture posterior joint is fixed and ached feel and causes joint passivity tetanic, or joint is light, in, severe active receiving
Limit, and swelling, pain occurs in joint, above-mentioned situation is owing to after fracture during clinical treatment, pass is caused by braking for a long time in joint
Caused by condyle contracture.Patient can not independently do joint motions or the degree of exercise because of fracture pain and method is improper mostly
And cause, small number of patients is because year is little, weak, prolonged illness bed causes deficiency in both Qi and blood, and muscle arteries and veins is become homeless foster, and joint also generation activity hinders
Hinder.At present, doctor trained in Western medicine is based on Drug therapy, although have certain curative effect, but toxic and side effects is bigger.Inventor is in clinic for many years
In treatment practice, applying treatment by Chinese herbs, not only achieve preferable curative effect, and side effect is little, method is easy.Chinese medicine has temperature
Qualcomm meridian, the effect of easing joint movement, by the therapeutical effect of medicine, can strengthen the blood circulation of local organization, promote muscle,
Tendon, the recovery of osseous tissue, muscle of loosening, tendon and ligament contracture, increase range of motion, promotion muscular strength and function of joint
Recover.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine preparation treating Anchylosis.Primary disease belongs to motherland's medical science
" numbness is sick ", " muscle gathers " category.The traditional Chinese medical science thinks that its cause of disease includes " healthy energy interior-deficiency " and " wind cold-damp invading in the interior ", and pathogen is jammed, QI and blood is coagulated
Stagnant, venation is obstructed crucial for its pathogenesis, and sick position is in muscle, meridians, joint.
It is an object of the invention to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment Anchylosis by
The Chinese medicine of following weight portion is made: Herba Passiflorae Wilsonii 20-30 part, Radix Pottsiae Laxiflorae 18-24 part, Caulis Chonemorphae Megacalycis 24-28 part, Rhizoma Fagopyri Cymosi
10-16 part, Herba Polygoni Perfoliati 10-16 part, Radix Clinopodii polycephali 15-25 part.
Preferred: Herba Passiflorae Wilsonii 25 parts, Radix Pottsiae Laxiflorae 21 parts, Caulis Chonemorphae Megacalycis 26 parts, Rhizoma Fagopyri Cymosi 13 parts, Herba Polygoni Perfoliati 13
Part, Radix Clinopodii polycephali 20 parts.
Preparation method: make decoction by traditional method.
Fang Zhong: Herba Passiflorae Wilsonii, Radix Pottsiae Laxiflorae, Caulis Chonemorphae Megacalycis are monarch drug, and Herba Polygoni Perfoliati has relaxing muscles and tendons to promote blood circulation, active promoting the circulation of blood, dispels
The merit of the stasis of blood is ministerial drug, and it is adjuvant drug that Radix Clinopodii polycephali has dampness removing energy active, heat-clearing and toxic substances removing；Rhizoma Fagopyri Cymosi has invigorating middle warmer for making medical instrument
Gas, foster taste, removing toxic substances of dispeling the wind are used as making medicine.
Toxicity test
1, laboratory animal cleaning grade healthy SD female rats 40, weight (195 ± 8) g, as chronic toxicity；
The female white mice in cleaning grade health Kunming 30, weight (27 ± 3) g, as acute toxicological experiment.Feed with normal diet, general
Logical drinking-water.Room temperature controls in (23 ± 3) DEG C, humidity (51 ± 4) %, natural lighting.
2, acute toxicological experiment is according to (Chinese medicine, researches on natural drugs registration service manual), selects cleaning grade health Kunming
Female white mice 30, is randomly divided into 2 groups, Chinese drug-treated group and each 15 of blank group.Chinese drug-treated group is administered orally 8g/d by adult normal
(being equivalent to crude drug 118g) is converted to the dosage of white mice, gavages Chinese medicine every day 1 time.Blank group gives 1mL/20g weight
0.9% sodium chloride injection gavages.
3, long term toxicity test cleaning grade healthy SD female rats 40, is randomly divided into 4 groups, Normal group and Chinese drug-treated group
Little, in, heavy dose of each 10.Matched group gives 1ml/20g weight 0.9% sodium chloride injection, Chinese drug-treated group little, in, big
Dosage group is that adult normal consumption is converted to the 5 of rat dosage, 15,50 times, i.e. 0.12g, 0.36g, 1.2g.Be gavage to
Medicine.Every day 1 time, experimental period is 3 months.
4, acute toxicity testing result white mice nothing in being administered 7d is dead, to observation post administration mice outward appearance, hair color, gloss
Normally, social behavior, reaction are all normal, ingest, drain normally.Manually put to death dissection after 7d, observe its heart, liver, spleen,
Lungs, kidney, brain, ovary, uterus are showed no exception.Pathological examination: dye in single-minded Yihong of Lignum Sappan (HE), Chinese drug-treated group internal organs table
Face is smooth, and in order, cell size, form are normal in organizational structure arrangement, and the dyeing of endochylema, karyon is clear, compares with blank group
No significant difference (P ＞ 0.05).
5, chronic toxicity result Chinese drug-treated group little, in, heavy dose of group and the outward appearance of rats in normal control group, hair color,
Social behavior, zest etc. and to surrounding, food, the equal not statistically significant of comparing difference (P ＞ 0.05) such as interest of water.
(P ＜ 0.05) is increased before the experiment of weight the most relatively this group after 4 groups of rat experiments, but the equal nothing of weight comparing difference after 4 groups of experiments
Statistical significance (P ＞ 0.05), blood cytology index, blood biochemical analysis index, important organ coefficient ratio after 4 groups of rat experiments
Compared with the equal not statistically significant of difference (P ＞ 0.05).At 4 groups of rats, after death important organ row staining pathologic section checks, HE dyes.
In order, cell size, form are normal for the arrangement of Chinese drug-treated group Rats Organs and Tissues organizational structure, and the dyeing of endochylema, karyon is clear, with normal control
Group comparing difference not statistically significant (P ＞ 0.05).
Toxicity test shows, the Chinese medicine preparation of the treatment Anchylosis of the present invention has no toxic reaction after being administered.
Clinical data
1, case selected by physical data is all from my institute in March, 2010 to outpatient service in February, 2014 inpatient, totally 300 example,
Man's 150 examples, female 150 example, age 18～60 years old, average (34.2 ± 2.15) year.On the basis of patient knows the inside story and is voluntary, we
Patient is divided into 8 groups；Only take Herba Passiflorae Wilsonii single medicinal material group be A group, only take Radix Pottsiae Laxiflorae single medicinal material group be B group, only take big
Calyx Chonemorpha eriostylis single medicinal material group be C group, only take Rhizoma Fagopyri Cymosi single medicinal material group be D group, only take Herba Polygoni Perfoliati single medicinal material group be E group,
Only taking Radix Clinopodii polycephali single medicinal material group is F group, and taking the present invention by embodiment two preparation group is treatment group, uses routine to treat
Method is matched group.Each group is compared not statistically significant (P ＞ 0.05) in the physical data such as age, sex, has comparability.
2, Therapeutic Method treatment group takes the Chinese medicine preparation made by embodiment of the present invention two, each single medicinal material group take with
Treatment group same concentrations same amount of single medicinal material preparation, each group every day 1 dose be 400ml, divides and takes for 2 times.Matched group therapy: postoperative
After fixing 4 weeks, autonomic function is taken exercise and is taken conventional western medicine and treated, and two groups equal 20 days is 1 course for the treatment of.
3, curative effect determinate standard is according to Chinese Medical Association's hand surgery meeting hands surgical function evaluation criteria, measures and suffer from after reparation
Total active range of motion (TAM) evaluation hands function of limb.Excellent: normal activity；Good: TAM ＞ is good for side 75%；Can: TAM ＞ is good for side
50%；Difference: TAM ＜ is good for side 50%.
4, comparitive study result after therapeutic outcome respectively organizes treatment two.
| Group | Number of cases | Excellent | Good | Difference | Total effective rate (%) |
| Treatment group | 90 | 50 | 38 | 2 | 97.8 |
| Matched group | 90 | 36 | 18 | 36 | 60.0 |
| A | 20 | 1 | 2 | 17 | 15.0 |
| B | 20 | 1 | 1 | 18 | 10.0 |
| C | 20 | 1 | 2 | 17 | 15.0 |
| D | 20 | 1 | 1 | 18 | 10.0 |
| E | 20 | 0 | 2 | 18 | 10.0 |
| F | 20 | 0 | 1 | 19 | 5.0 |
The therapeutic effect that the therapeutic effect of the Chinese medicine preparation treatment Anchylosis of the present invention is organized far better than it；Control
The total effective rate for the treatment of group is apparently higher than each single medicinal material group total effective rate sum；It follows that the therapeutic effect for the treatment of group is each list
The mutual synergistic result of taste medicine.
5, in the patient of above treatment, treatment group has 10 example gravamens, not only has the pain of Anchylosis, and
Also suffer from hypertension in various degree.When after the Chinese medicine preparation taking the present invention, not only Anchylosis rehabilitation, and
Hypertension have also been obtained treatment in various degree.After obtaining this message, we are immediately to 30 example hyperpietics, take by this
The decoction that invention embodiment two is made is treated, and curative effect judging standard is divided into (1) effective: 1. diastolic pressure declines ＞
10mmHg, and reach normal range；Though 2. diastolic pressure does not drops to normally but has declined 15mmHg or above person.Above two, reach
It is effective to its one；(2) effective: 1. diastolic pressure declines ＜ 10mmHg, but oneself reaches normal range；2. diastolic pressure is relatively treated
Front decline 5-14mmHg, but not up to normal range；3. ＞ 20mmHg is declined before shrinking pressure relatively treatment.Above three, possesses it
In a person, be effectively；(3) invalid: not up in effective standard any one person be invalid.
Its therapeutic outcome such as following table.
| Number of cases | Effective | Effectively | Invalid | Total effective rate (%) |
| 30 | 20 | 7 | 3 | 90 |
As known from the above, it is evident in efficacy that Chinese medicine preparation of the present invention not only treats Anchylosis, more gratifying
Be that hypertension is had good therapeutic effect, clinic popularization and application.
Claims (2)
1. the Chinese medicine preparation treating Anchylosis, it is characterised in that this Chinese medicine preparation is by the Chinese medicine of following weight portion
Make: Herba Passiflorae Wilsonii 20-30 part, Radix Pottsiae Laxiflorae 18-24 part, Caulis Chonemorphae Megacalycis 24-28 part, Rhizoma Fagopyri Cymosi 10-16 part, Herba Polygoni Perfoliati
10-16 part, Radix Clinopodii polycephali 15-25 part.
A kind of Chinese medicine preparation treating Anchylosis, it is characterised in that this Chinese medicine preparation
It is made up of the Chinese medicine of following weight portion: Herba Passiflorae Wilsonii 25 parts, Radix Pottsiae Laxiflorae 21 parts, Caulis Chonemorphae Megacalycis 26 parts, Rhizoma Fagopyri Cymosi 13 parts, shoulder
Plate returns 13 parts, Radix Clinopodii polycephali 20 parts.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610628760.6A CN106138246A (en) | 2016-07-26 | 2016-07-26 | A kind of Chinese medicine preparation treating Anchylosis |
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| CN201610628760.6A CN106138246A (en) | 2016-07-26 | 2016-07-26 | A kind of Chinese medicine preparation treating Anchylosis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038908A (en) * | 2016-07-14 | 2016-10-26 | 张金华 | Traditional Chinese medicinal preparation for treating cerebral concussion |
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|---|---|---|---|---|
| CN102755591A (en) * | 2012-06-16 | 2012-10-31 | 王少伟 | Chinese medicinal plaster for treating bone fracture |
| CN102793852A (en) * | 2012-08-27 | 2012-11-28 | 王永刚 | Preparation method for traditional Chinese medicine lotion for treatment of fever-type closed fracture |
| CN103860734A (en) * | 2014-03-14 | 2014-06-18 | 于蔚蔚 | Traditional Chinese medicine fuming and washing agent for treating ankylosis after wrist fracture and nursing method |
| CN104147300A (en) * | 2014-08-13 | 2014-11-19 | 徐蒙 | Traditional Chinese medicine fuming-washing decoction preparation for treating anchylosis after limb fracture of children |
| CN105288059A (en) * | 2015-10-09 | 2016-02-03 | 马浩广 | Traditional Chinese medicine fumigating and washing agent for treating anchylosis after wrist fracture |
| CN105327117A (en) * | 2015-11-02 | 2016-02-17 | 王玉亮 | Traditional Chinese medicine composition for treating tibial and fibular fractures |
| CN105663469A (en) * | 2016-03-05 | 2016-06-15 | 廉慧 | Chinese medicine external application agent for treating bone fractures and nursing method |
-
2016
- 2016-07-26 CN CN201610628760.6A patent/CN106138246A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755591A (en) * | 2012-06-16 | 2012-10-31 | 王少伟 | Chinese medicinal plaster for treating bone fracture |
| CN102793852A (en) * | 2012-08-27 | 2012-11-28 | 王永刚 | Preparation method for traditional Chinese medicine lotion for treatment of fever-type closed fracture |
| CN103860734A (en) * | 2014-03-14 | 2014-06-18 | 于蔚蔚 | Traditional Chinese medicine fuming and washing agent for treating ankylosis after wrist fracture and nursing method |
| CN104147300A (en) * | 2014-08-13 | 2014-11-19 | 徐蒙 | Traditional Chinese medicine fuming-washing decoction preparation for treating anchylosis after limb fracture of children |
| CN105288059A (en) * | 2015-10-09 | 2016-02-03 | 马浩广 | Traditional Chinese medicine fumigating and washing agent for treating anchylosis after wrist fracture |
| CN105327117A (en) * | 2015-11-02 | 2016-02-17 | 王玉亮 | Traditional Chinese medicine composition for treating tibial and fibular fractures |
| CN105663469A (en) * | 2016-03-05 | 2016-06-15 | 廉慧 | Chinese medicine external application agent for treating bone fractures and nursing method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038908A (en) * | 2016-07-14 | 2016-10-26 | 张金华 | Traditional Chinese medicinal preparation for treating cerebral concussion |
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Application publication date: 20161123 |