CN106110385A - A kind of preparation method of II degree of burn Wound-protection liquid - Google Patents
A kind of preparation method of II degree of burn Wound-protection liquid Download PDFInfo
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- CN106110385A CN106110385A CN201610610046.4A CN201610610046A CN106110385A CN 106110385 A CN106110385 A CN 106110385A CN 201610610046 A CN201610610046 A CN 201610610046A CN 106110385 A CN106110385 A CN 106110385A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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Abstract
The invention provides the preparation method of a kind of II degree of burn Wound-protection liquid, first take Radix Arnebiae (Radix Lithospermi), add alcoholic solution and soak, seepage pressure effects, percolate concentrates, obtains Radix Arnebiae extract；Again xanthan gum, sodium carboxymethyl cellulose, Oppanol, modified rosin, dilauryl thiodipropionate are added in deionized water, stirring, obtain mixed liquor；Then Radix Arnebiae extract is added in mixed liquor, add under agitation squalane, benzoyl peroxide, to benzene methanesulfonic acid and tricalcium phosphate, dispersion, 4～10 DEG C stand 1～3h, to obtain final product.The Wound-protection liquid of the present invention can effectively shorten wound healing time, reduces changing dressing for patient pain degree, wound infection rate, saves medical expense for patient, become apparent from the resultant effect of II degree of burn treating than traditional remedies.
Description
Technical field
The invention belongs to surgery medical preparation technical field, be specifically related to the preparation side of a kind of II degree of burn Wound-protection liquid
Method.
Background technology
Burn is one of unexpected skin lesion common in daily life, is only second to vehicle accident, traumatic injury scratch, assaults,
Due to the most common, therefore burn bigger on publilc health impact.The main purpose of burn treating is not only treatment
Life, alleviates patient pain, quickly-healing wound surface, the healing quality of patient to be made every effort to, activity of as far as possible resuming production, self-care energy
Power, the quality of life having had.
II degree of burn can involve the mastoid process layer of skin corium or corium, and the principle processed for II degree of burn is to prevent and subtract
Subinfection, the treatment of shallow two degree, in the case of without infecting, if retaining wound surface necrosis epidermis, provides suitable healing for wound healing
Environment, often there are the abnormal sensories such as pruritus in major part healing in agglutination in general 2 weeks, after healing sometimes for a long time with
Local pigment changes；Deep two degree of wound healings are than shallow two degree long 1 to 2 weeks, if wound surface causes wound surface deepening because of infection, pressurized etc.,
Needing skin grafting ability wound closure, before wound surface heals completely, granulation tissue can preferentially form to protect at the wound surface of non-epithelization
Protecting wound surface, but the granulation tissue of hyperplasia causes scar hyperplasia, the scar tissue of hyperplasia can cause joint locally abnormal
Shape, afunction, disfeature, have a strong impact on patients ' life quality.Therefore, reduce scar tissue growth, improve wound healing matter
Amount, significant to burn prognosis.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art to provide the preparation method of a kind of II degree of burn Wound-protection liquid,
This Wound-protection liquid can effectively shorten wound healing time, reduces changing dressing for patient pain degree, wound infection rate.
The preparation method of a kind of II degree of burn Wound-protection liquid, comprises the following steps:
Step 1, takes Radix Arnebiae (Radix Lithospermi), adds alcoholic solution and soaks, seepage pressure effects, and percolate concentrates, obtains Radix Arnebiae extract；
Step 2, in parts by weight, by xanthan gum 5～10 parts, sodium carboxymethyl cellulose 1～4 parts, Oppanol 2～5 parts,
Modified rosin 0.8～2.4 parts, dilauryl thiodipropionate 1.2～3.5 parts add in deionized water 10 parts, stirring, are mixed
Close liquid；
Step 3, in parts by weight, adds in mixed liquor by Radix Arnebiae extract 3～7 parts, adds squalane 0.4 under agitation
～1.5 parts, benzoyl peroxide 0.2～0.9 part, to benzene methanesulfonic acid 0.1～0.6 part and tricalcium phosphate 0.3～0.7 part, dispersion,
4～10 DEG C stand 1～3h, to obtain final product.
Further, soaking in step 1 is to use the ethanol water of 60～80v/v% to soak 24h.
Further, in step 1, percolate is concentrated into water content 10～15wt%.
Further, in step 2, stirring condition is 300～400rpm, 20～30min.
Further, in step 3, dispersion condition is 1000～1500rpm, 15～20min.
Further, step 2 also needs to add organic acid 3～6 parts.
Further, the one during described organic acid is tartaric acid, citric acid, sulfinic acid, LOMAR PWA EINECS 246-676-2 or sulfosalicylic acid.
The Wound-protection liquid of the present invention can effectively shorten wound healing time, reduces changing dressing for patient pain degree, wound infection rate,
Save medical expense for patient, the resultant effect of II degree of burn treating is become apparent from than traditional remedies.
Detailed description of the invention
Embodiment 1
The preparation method of a kind of II degree of burn Wound-protection liquid, comprises the following steps:
Step 1, takes Radix Arnebiae (Radix Lithospermi), adds alcoholic solution and soaks, seepage pressure effects, and percolate concentrates, obtains Radix Arnebiae extract；
Step 2, in parts by weight, by xanthan gum 5 parts, sodium carboxymethyl cellulose 1 part, Oppanol 2 parts, modified rosin
0.8 part, dilauryl thiodipropionate 1.2 parts add in deionized water 10 parts, stirring, obtain mixed liquor；
Step 3, in parts by weight, adds in mixed liquor by Radix Arnebiae extract 3 parts, under agitation add squalane 0.4 part,
Benzoyl peroxide 0.2 part, to benzene methanesulfonic acid 0.1 part and tricalcium phosphate 0.3 part, dispersion, 4 DEG C stand 3h, to obtain final product.
Wherein, soaking in step 1 is to use the ethanol water of 60～80v/v% to soak 24h, and percolate is concentrated into aqueous
Amount is at 10wt%；In step 2, stirring condition is 300rpm, 30min；In step 3, dispersion condition is 1000rpm, 20min.
Embodiment 2
The preparation method of a kind of II degree of burn Wound-protection liquid, comprises the following steps:
Step 1, takes Radix Arnebiae (Radix Lithospermi), adds alcoholic solution and soaks, seepage pressure effects, and percolate concentrates, obtains Radix Arnebiae extract；
Step 2, in parts by weight, by xanthan gum 7 parts, sodium carboxymethyl cellulose 3 parts, Oppanol 4 parts, modified rosin
1.3 parts, dilauryl thiodipropionate 1.7 parts add in deionized water 10 parts, stirring, obtain mixed liquor；
Step 3, in parts by weight, adds in mixed liquor by Radix Arnebiae extract 6 parts, under agitation add squalane 0.9 part,
Benzoyl peroxide 0.7 part, to benzene methanesulfonic acid 0.5 part and tricalcium phosphate 0.4 part, dispersion, 6 DEG C stand 3h, to obtain final product.
Wherein, soaking in step 1 is to use the ethanol water of 60～80v/v% to soak 24h, and percolate is concentrated into aqueous
Amount is at 15wt%；In step 2, stirring condition is 400rpm, 20min；In step 3, dispersion condition is 1200rpm, 20min.
Embodiment 3
The preparation method of a kind of II degree of burn Wound-protection liquid, comprises the following steps:
Step 1, takes Radix Arnebiae (Radix Lithospermi), adds alcoholic solution and soaks, seepage pressure effects, and percolate concentrates, obtains Radix Arnebiae extract；
Step 2, in parts by weight, by xanthan gum 6 parts, sodium carboxymethyl cellulose 2 parts, Oppanol 4 parts, modified rosin
1.8 parts, dilauryl thiodipropionate 2.1 parts add in deionized water 10 parts, stirring, obtain mixed liquor；
Step 3, in parts by weight, adds in mixed liquor by Radix Arnebiae extract 4 parts, under agitation add squalane 0.9 part,
Benzoyl peroxide 0.5 part, to benzene methanesulfonic acid 0.4 part and tricalcium phosphate 0.5 part, dispersion, 8 DEG C stand 2h, to obtain final product.
Wherein, soaking in step 1 is to use the ethanol water of 60～80v/v% to soak 24h, and percolate is concentrated into aqueous
Amount is at 13wt%；In step 2, stirring condition is 300rpm, 30min；In step 3, dispersion condition is 1000rpm, 20min.
Embodiment 4
The preparation method of a kind of II degree of burn Wound-protection liquid, comprises the following steps:
Step 1, takes Radix Arnebiae (Radix Lithospermi), adds alcoholic solution and soaks, seepage pressure effects, and percolate concentrates, obtains Radix Arnebiae extract；
Step 2, in parts by weight, by xanthan gum 10 parts, sodium carboxymethyl cellulose 4 parts, Oppanol 5 parts, modified rosin
2.4 parts, dilauryl thiodipropionate 3.5 parts add in deionized water 10 parts, stirring, obtain mixed liquor；
Step 3, in parts by weight, adds in mixed liquor by Radix Arnebiae extract 7 parts, under agitation add squalane 1.5 parts,
Benzoyl peroxide 0.9 part, to benzene methanesulfonic acid 0.6 part and tricalcium phosphate 0.7 part, dispersion, 10 DEG C stand 1h, to obtain final product.
Wherein, soaking in step 1 is to use the ethanol water of 60～80v/v% to soak 24h, and percolate is concentrated into aqueous
Amount is at 10wt%；In step 2, stirring condition is 400rpm, 20min；In step 3, dispersion condition is 1500rpm, 15min.
Embodiment 5
The present embodiment is with the difference of embodiment 3: also need in step 2 add organic acid 3～6 parts, organic acid be tartaric acid,
One in citric acid, sulfinic acid, LOMAR PWA EINECS 246-676-2 or sulfosalicylic acid.
The preparation method of a kind of II degree of burn Wound-protection liquid, comprises the following steps:
Step 1, takes Radix Arnebiae (Radix Lithospermi), adds alcoholic solution and soaks, seepage pressure effects, and percolate concentrates, obtains Radix Arnebiae extract；
Step 2, in parts by weight, by xanthan gum 6 parts, sodium carboxymethyl cellulose 2 parts, Oppanol 4 parts, modified rosin
1.8 parts, dilauryl thiodipropionate 2.1 parts, citric acid 4 parts add in deionized water 10 parts, stirring, obtain mixed liquor；
Step 3, in parts by weight, adds in mixed liquor by Radix Arnebiae extract 4 parts, under agitation add squalane 0.9 part,
Benzoyl peroxide 0.5 part, to benzene methanesulfonic acid 0.4 part and tricalcium phosphate 0.5 part, dispersion, 8 DEG C stand 2h, to obtain final product.
Wherein, soaking in step 1 is to use the ethanol water of 60～80v/v% to soak 24h, and percolate is concentrated into aqueous
Amount is at 13wt%；In step 2, stirring condition is 300rpm, 30min；In step 3, dispersion condition is 1000rpm, 20min.
Choose patient 180 example, shallow two degree and deep each 90 examples of two degree of patients.Shallow two degree, comprise 30 examples in deep two degree of each group of groups and make
With treatment group and the matched group of 30 examples use traditional dressing of embodiment 3 and embodiment.Treatment group totally 90 example patient, wherein male
57 examples, women 33 example, age 1-55 year, burn surface area 2%-30%TBSA.Matched group 90 example patient, wherein male 51 example, women
39 examples, age 2-60 year, burn surface area 2%-25%TBSA.Shallow two degree for the treatment of groups and the sex of matched group patient, age, burn
The aspect basic simlarity such as area, no significant difference (P ＞ 0.05).
After treatment group is admitted to hospital, wound surface uses the quick debridement of simple wound excision, and conventional iodophor disinfection wound surface and surrounding skin are low
After the complete vesicle of drain of position, removing dirt and pollute beancurd sheet, retaining other complete beancurd sheet as far as possible, normal saline is dry after cleaning wound surface
Gauze blots wound surface and surrounding skin liquid, smears Wound-protection liquid at skin injury, and the scope of smearing should exceed edge of wound at least 1cm.
After comparison gives same method debridement, smear traditional dressing and use sterile gauze to wrap up wound surface.
Shallow I group of healing time of two degree of patient treatments is 10.4d ± 2.5, and treating II group is 9.4d ± 1.5, shallow two degree of patients
Matched group healing time is 12.4d ± 1.6.Deep I group of healing time of two degree of patient treatments is 15.9d ± 1.7, and treating II group is
13.9d ± 2.1, deep two degree of patient's matched group healing times are 20.5d ± 1.9.Shallow two degree, the treatment group healing of deep two degree of patients
Time is all shorter than matched group, and the therapeutic effect of two kinds of degree of depth compares difference statistically significant (P < 0.01).
Wound healing observes cicatrix growth after three months, the I group of cicatrix scoring of shallow two degree of patient treatments is 3.37 ± 1.13, controls
Treating II group is 2.89 ± 1.05, and matched group is 4.03 ± 0.96.The I group of cicatrix scoring of deep two degree of patient treatments is 6.00 ± 0.98,
Treating II group is 4.75 ± 1.24, and matched group is 8.77 ± 1.19.Cicatrix scoring phase comparisons in three months of two kinds of degree of depth treatment groups
According to group difference the most statistically significant (P < 0.01).Illustrate shallow two degree and deep two degree for the treatment of group wounds heal three months after scar
Trace proliferative conditions is superior to matched group.
Claims (7)
1. the preparation method of II degree of burn Wound-protection liquid, it is characterised in that: comprise the following steps:
Step 1, takes Radix Arnebiae (Radix Lithospermi), adds alcoholic solution and soaks, seepage pressure effects, and percolate concentrates, obtains Radix Arnebiae extract；
Step 2, in parts by weight, by xanthan gum 5～10 parts, sodium carboxymethyl cellulose 1～4 parts, Oppanol 2～5 parts,
Modified rosin 0.8～2.4 parts, dilauryl thiodipropionate 1.2～3.5 parts add in deionized water 10 parts, stirring, are mixed
Close liquid；
Step 3, in parts by weight, adds in mixed liquor by Radix Arnebiae extract 3～7 parts, adds squalane 0.4 under agitation
～1.5 parts, benzoyl peroxide 0.2～0.9 part, to benzene methanesulfonic acid 0.1～0.6 part and tricalcium phosphate 0.3～0.7 part, dispersion,
4～10 DEG C stand 1～3h, to obtain final product.
The preparation method of II degree of burn Wound-protection liquid the most according to claim 1, it is characterised in that: in step 1, immersion is
The ethanol water using 60～80v/v% soaks 24h.
The preparation method of II degree of burn Wound-protection liquid the most according to claim 1, it is characterised in that: percolate in step 1
It is concentrated into water content 10～15wt%.
The preparation method of II degree of burn Wound-protection liquid the most according to claim 1, it is characterised in that: step 2 stirs bar
Part is 300～400rpm, 20～30min.
The preparation method of II degree of burn Wound-protection liquid the most according to claim 1, it is characterised in that: step 3 is disperseed bar
Part is 1000～1500rpm, 15～20min.
The preparation method of II degree of burn Wound-protection liquid the most according to claim 1, it is characterised in that: step 2 also needs to
Add organic acid 3～6 parts.
The preparation method of II degree of burn Wound-protection liquid the most according to claim 6, it is characterised in that: described organic acid is wine
One in stone acid, citric acid, sulfinic acid, LOMAR PWA EINECS 246-676-2 or sulfosalicylic acid.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610610046.4A CN106110385A (en) | 2016-07-29 | 2016-07-29 | A kind of preparation method of II degree of burn Wound-protection liquid |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610610046.4A CN106110385A (en) | 2016-07-29 | 2016-07-29 | A kind of preparation method of II degree of burn Wound-protection liquid |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297363A (en) * | 1998-03-12 | 2001-05-30 | 卫生与营养实验室 | Hydrocolloid adhesive mass useful for medical purpose |
| CN101670126A (en) * | 2009-10-10 | 2010-03-17 | 姚辉 | Fructus forsythiae volatile oil medical hydrocolloid dressing and preparation method thereof |
| CN102600363A (en) * | 2012-03-15 | 2012-07-25 | 沈慰平 | Traditional Chinese compound preparation for deep burnt wound restoration and tissue and skin regeneration promotion and preparation method of traditional Chinese compound preparation |
| CN104274859A (en) * | 2014-10-17 | 2015-01-14 | 云南白药集团无锡药业有限公司 | Hydrocolloid patch containing panax notoginseng saponins and preparation method thereof |
| CN104784741A (en) * | 2015-04-23 | 2015-07-22 | 武汉市思泰利医疗器械发展有限公司 | Functional medical dressing containing chitosan and hydrocolloid |
-
2016
- 2016-07-29 CN CN201610610046.4A patent/CN106110385A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297363A (en) * | 1998-03-12 | 2001-05-30 | 卫生与营养实验室 | Hydrocolloid adhesive mass useful for medical purpose |
| CN101670126A (en) * | 2009-10-10 | 2010-03-17 | 姚辉 | Fructus forsythiae volatile oil medical hydrocolloid dressing and preparation method thereof |
| CN102600363A (en) * | 2012-03-15 | 2012-07-25 | 沈慰平 | Traditional Chinese compound preparation for deep burnt wound restoration and tissue and skin regeneration promotion and preparation method of traditional Chinese compound preparation |
| CN104274859A (en) * | 2014-10-17 | 2015-01-14 | 云南白药集团无锡药业有限公司 | Hydrocolloid patch containing panax notoginseng saponins and preparation method thereof |
| CN104784741A (en) * | 2015-04-23 | 2015-07-22 | 武汉市思泰利医疗器械发展有限公司 | Functional medical dressing containing chitosan and hydrocolloid |
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Application publication date: 20161116 |
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