CN106074824A - Enhancing immunity and the compositions of prophylactic treatment influenza, preparation technology and purposes - Google Patents
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- 201000005113 shigellosis Diseases 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 1
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- 229950005143 sitosterol Drugs 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
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- 208000020685 sleep-wake disease Diseases 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- -1 sulfur cyanobenzene ester Chemical class 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
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- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- XLTFNNCXVBYBSX-UHFFFAOYSA-N wogonin Chemical compound COC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=CC=C1 XLTFNNCXVBYBSX-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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Abstract
The invention provides a kind of enhancing immunity and the compositions of prophylactic treatment influenza, in parts by weight, said composition includes: Maca extract 15～55 parts, Scutellaria baicalensis extract 15～40 parts, Echinacea extract 5～30 parts, Radix Isatidis extract 5～30 parts, Herba Houttuyniae extract 5～20 parts and Fructus Rosae Normalis extract 5～15 parts.The preparation method of said composition includes: extracted obtain each extract, is then mixed to get said composition.Said composition can be applicable to preparation improve immunologic function or/and prophylactic treatment flu medicine in.And said composition can be applicable to preparation improve immunologic function or/and prophylactic treatment flu food in.Said composition contains multiple bioactive ingredients, it is possible to be effectively improved the immunity of human body, has resisiting influenza virus and immunostimulation, can strengthen the premunition of human body, prevents and treats influenza.
Description
Technical field
The present invention relates to medicine or field of food, in particular to a kind of enhancing immunity and prophylactic treatment influenza
Compositions, preparation technology and purposes.
Background technology
Influenza is called for short influenza, is the acute respiratory infection that causes of influenza virus, is a kind of infectiousness
By force, the disease that spread speed is fast.Influenza mainly by the spittle in air, interpersonal contact or with contaminated article
Contact transmission.Typical clinical symptoms is: anxious high heat, overall pain, the most weak and slight respiratory symptom.The general autumn and winter
Season is its high-incidence season, and caused complication and the phenomena of mortality are the most serious.Influenza is to be caused by influenza virus, can be divided into
First, second, the third three types, often there is antigenic variation in Alphavirus, infectiousness is big, propagates rapidly, easily occurs the most popular.Stream
Row sexuality emits and typically has self limiting, it is possible to by self immunity fully recover, but infant, old people and exist cardiopulmonary basis
The severe complications such as the easy Complicating Pneumonia In Patients of patient of disease and cause death.Meanwhile, along with progress and the economic development of society, respectively
The each industry of row develops rapidly, and social competition is growing more intense, and causes majority of populations autoimmunity low, is highly prone to antibacterial, disease
The infection of poison and fungus etc., liable to illness.Increase the weight of because of the most ill consumption causing body, typically have a delicate constitution, nutrition not
The performances such as good, lethargy, fatigue and weak, appetite reduction, sleep disorder, flu is sick etc. every time is required for long time
Can recover, and the state of an illness is the most repeatedly, if things go on like this can cause body damage, easily induce major disease.
At present, grippal antiviral agents mainly has Oseltamivir, amantadine and a rimantadine etc., but these medicines
The side effect of thing is more, gastrointestinal tract, nervus centralis, kidney even liver etc. can be produced untoward reaction, and life-time service holds very much
It is easily generated drug resistance.So, find safe and effective anti-influenza virus medicament or health product just seem particularly significant.
Summary of the invention
It is an object of the invention to provide a kind of enhancing immunity and the compositions of prophylactic treatment influenza, said composition contains
Multiple bioactive ingredients, it is possible to be effectively improved the immunity of human body, has resisiting influenza virus and immunostimulation, can strengthen
The premunition of human body, prevents and treats influenza.
Another object of the present invention is to provide the preparation work of the compositions of a kind of enhancing immunity and prophylactic treatment influenza
Skill, this technique is simple, it is easy to operation.
Another object of the present invention is to the compositions that enhancing immunity and prophylactic treatment influenza are provided exempt from preparation raising
Purposes in the medicine of epidemic disease function and/or prophylactic treatment flu.
Another object of the present invention is to the compositions that enhancing immunity and prophylactic treatment influenza are provided exempt from preparation raising
Purposes in the food of epidemic disease function and/or prophylactic treatment flu.
In order to realize the above-mentioned purpose of the present invention, spy by the following technical solutions:
A kind of enhancing immunity and the compositions of prophylactic treatment influenza, in parts by weight, said composition includes: Lepidinm meyenii Walp
Extract 15～55 parts, Scutellaria baicalensis extract 15～40 parts, Echinacea extract 5～30 parts, Radix Isatidis extract 5～30 parts, fish
Raw meat grass extract 5～20 parts and Fructus Rosae Normalis extract 5～15 parts.
It addition, the preparation technology of the compositions of a kind of enhancing immunity and prophylactic treatment influenza, comprising:
Extraction step: Lepidinm meyenii Walp and Echinacea extract through ethanol water respectively and obtain Maca extract and Echinacea extraction
Thing；Radix Scutellariae, Radix Isatidis and Herba Houttuyniae carry through water respectively and obtain Radix Scutellariae extract, Radix Isatidis extract and Herba Houttuyniae extraction successively
Thing；Fructus Rosae Normalis is squeezed the juice, is concentrated to give Fructus Rosae Normalis extract；
Blend step: Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, Herba Houttuyniae are extracted
Thing and Fructus Rosae Normalis extract are mixed to prepare.
It addition, the compositions of above-mentioned enhancing immunity and prophylactic treatment influenza improves immunologic function and/or prevention in preparation
Purposes in the medicine for the treatment of flu.
It addition, the compositions of above-mentioned enhancing immunity and prophylactic treatment influenza improves immunologic function and/or prevention in preparation
Purposes in the food for the treatment of flu.
Compared with prior art, the invention have the benefit that
Maca extract infected by influenza has the strongest inhibitory action, shows A type and Influenza B virus effect especially
Write, can effectively treat influenza.Lepidinm meyenii Walp is new resource food, is free from side effects, and is the most promising antiviral of one
Raw material, and Lepidinm meyenii Walp has the effect of enhancing immunity, resisting fatigue, can effectively prevent influenza.During Radix Scutellariae is traditional
Medical material, has good antibacterial and antivirus action, and its clinical antibiotic property is better than Rhizoma Coptidis, and does not develops immunity to drugs.Radix Isatidis,
Herba Houttuyniae also has the most antibacterial and antivirus action.Echinacea has stimulating immune system cytoactive, can suppress influenza
Virus, its antiviral activity gives the credit to the inhibitory action of hyaluronidase, the virus receptor on energy block cell surface.Echinacea exists
Abroad it is widely used in enhancing immunity, also serves as the adjuvant therapy medicaments of flu, be free from side effects.Fructus Rosae Normalis is the king of vitamin C,
100g fresh Fructus Rosae Normalis Vitamin C content about 1800～3000mg, bigger to vitamin C requirements during human body flu, take during flu
Vitamin C can shorten flu convalescent period.
In the compositions that the present invention provides, each component is natural product, containing the multiple physiologically active thing useful to human body
Matter, it is to avoid the side effect that synthetic material is brought.When Maca extract and Radix Scutellariae extract cooperate, Radix Scutellariae extracts
Baicalin in thing, baicalin etc. have synergism with the effective ingredient in Maca extract, it is possible to enhancing composition anti-
Antiviral potency.Echinacea extract, Radix Isatidis extract, cordate houttuynia extract have the most antibacterial, antiviral and enhancing
The function of immunity, complements each other between each component, has cooperative effect, to strengthening the immunity of human body, preventing and treat stream
Row sexuality emits and has good effect, and the present invention is not likely to produce drug resistance, has no side effect and untoward reaction.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but those skilled in the art will
Understanding, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.In embodiment unreceipted specifically
Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument unreceipted production firm person, be
Can be by the commercially available conventional products bought and obtain.
The present invention provides a kind of enhancing immunity and the compositions of prophylactic treatment influenza, in parts by weight, this combination
Thing includes: Maca extract 15～55 parts, Scutellaria baicalensis extract 15～40 parts, Echinacea extract 5～30 parts, Radix Isatidis extract
5～30 parts, Herba Houttuyniae extract 5～20 parts and Fructus Rosae Normalis extract 5～15 parts.
The rhizome of Lepidinm meyenii Walp (Lepidium meyenii) likeness in form Radix Raphani, traditionally as food and medical herbs.Lepidinm meyenii Walp is rich in 55 kinds
Natural nutrient, including several amino acids, unsaturated fatty acid, vitamin, mineral etc., possibly together with macamide, Lepidinm meyenii Walp alkene,
Sterol, glucosinolate and catabolite thereof different sulfur cyanobenzene ester, polyphenols isoreactivity material.Lepidinm meyenii Walp alkene and macamide etc. are lived
Property material can remove the free radical in human body, under oxidative stress status provide cytoprotective function, adjust and balanced human
Hormonal system, physical strength reinforcing, improves energy, firm immune system, improves sub-health status, can prevent and treat multiple disease
Sick.Toxicological study result the most for many years shows, edible Lepidinm meyenii Walp is without any side effects.
Lepidinm meyenii Walp originates in the mountain area, Andean of Peru more than height above sea level 3500m.The health-care effect of Lepidinm meyenii Walp is increasingly for people institute
Accepting, the planting range of Lepidinm meyenii Walp constantly expands.The Lepidinm meyenii Walp of the present invention is preferably the producing region Lepidinm meyenii Walp at more than height above sea level 3000m, Gao Hai
Pulling out the Lepidinm meyenii Walp in the content of active component low altitude area to be far above producing region in the Lepidinm meyenii Walp in producing region, the effect of its resisiting influenza virus is higher.
Radix Scutellariae (Scutellaria baicalensis) is labiate, is traditional Chinese crude drug, is used as medicine with root, has
Heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery
The diseases such as disease, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The pharmacological action of Radix Scutellariae has: antibacterial, antiviral, it is possible to press down
Influenza virus processed and hepatitis B virus etc., improve body's immunity.Baicalin can improve macrophage, NK cell merit
Can, antipyretic, calm, protect the liver, function of gallbladder promoting etc..Modern study proves, Radix Scutellariae is mainly containing baicalin, baicalin, wogonin, Chinese Radix Scutellariae
The compositions such as glycoside, neobaicalein, β～sitosterol, have significant immunoregulation and anti-cancer function, and stronger antibacterial activity.
Its antimicrobial spectrum is relatively wide, and various bacteria, dermatophytes, leptospira etc. are had inhibitory action.Even if it is anti-to penicillin etc.
The staphylococcus aureus that raw element develops immunity to drugs, the most very sensitive to Radix Scutellariae.Radix Scutellariae also has blood pressure lowering, calmness, diuresis, guarantor
Liver, function of gallbladder promoting, antiallergic, releasing smooth muscle spasm etc. act on.Clinically by scutellaria for treating children with acute respiratory infection, infectiousness
Hepatitis, chronic tracheitis, acute bacillary dysentery, pyelonephritis etc., all can obtain good effect.
Echinacea (Echinacea) is a kind of Echinacea plant originating in North America and southern Canada, containing polysaccharide,
The several physiological active substances such as flavone, caffeinic derivant, quintessence oil, alkylamine and alkaloid, at US and European by extensively
Use, be used for treating venom, gingiva and oral disease, catch a cold, cough, have sore throat swell and ache, gastrointestinal disease and septicemia.Purple
Cone chrysanthemum is generally considered have immunological enhancement, can stimulate in human body the immunocyte vigor such as leukocyte, improve body self
Immunity.
Radix Isatidis (Isatis tinctoria) is plant Isatis indigotica Fort. or the dry root of grass Folium Isatidis, is the Chinese medicine of Chinese tradition
Material, has heat-clearing and toxic substances removing, antibiosis and antiviral functions, is one of the composition of multiple cold-treating preparation.Banlangen Polysaccharide has and carries simultaneously
Effect for immunologic function.
Herba Houttuyniae acrid in the mouth, cold, return lung meridian.It can heat-clearing and toxic substances removing, detumescence treatment skin ulcer, promoting urination to remove dampness, clearing away heat to cure dysentery, stomach invigorating
Help digestion, with controlling excess-heat, pyretic toxicity, damp, disease heat be suffer from lung abscess, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc..Modern pharmacology
Experiment shows, Herba Houttuyniae has the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.
Fructus Rosae Normalis is the king of vitamin C, 100g fresh Fructus Rosae Normalis Vitamin C content about 1800～3000mg.Vitamin is to hold health
A healthy necessary class organic compound, this kind of material neither constitute the raw material of bodily tissue, is not energy in vivo
Source, a but class Auto-regulator, play an important role in substance metabolism.Vitamin C is a kind of antioxidant, it is possible to protection
Health avoids the infringement of free radical, and enhancing body immunity and antiviral are had certain effect.To vitamin C during human body flu
Demand is bigger, takes vitamin C and can shorten flu convalescent period during flu.
In preferred embodiment of the present invention, in parts by weight, compositions includes: above-mentioned Maca extract 20～45
Part, Scutellaria baicalensis extract 20～30 parts, Echinacea extract 10～20 parts, Radix Isatidis extract 10～20 parts, Herba Houttuyniae extract 5
～15 parts and Fructus Rosae Normalis extract 5～10 parts.By the compositions enhancing immunity of this proportions, prevent and treat popular sexuality
The effect emitted is higher, and the proportioning effect of functional components is more excellent.
In preferred embodiment of the present invention, the compositions of above-mentioned enhancing immunity and prophylactic treatment influenza also includes auxiliary
Material, adjuvant is selected from one or more of starch, microcrystalline Cellulose, magnesium stearate and correctives.In parts by weight, adjuvant
Including: starch 10～30 parts, microcrystalline Cellulose 5～15 parts, magnesium stearate 1～3 parts and correctives 0～5 parts.Starch and crystallite are fine
Dimension element all can be as the filler prepared in production process, disintegrating agent, dispersant etc..The particularly suitable oils of magnesium stearate, extractum
The granulation of class medicine, the granule made has good mobility and compressibility, is alternatively arranged as suspending agent and the increasing of liquid preparation
Thick dose etc..Add correctives and can improve the mouthfeel of preparation, be more easy to be accepted by user.The adjuvant adding said ratio makes
The stability of compositions is more preferable, and the drug effect holding time is longer.
In preferred embodiment of the present invention, correctives is selected from citric acid, malic acid, xylitol, the one of Mel or many
Kind.Citric acid and malic acid are conventional acidic flavoring agent, and being used for improving mouthfeel, xylitol and Mel can use as sweeting agent,
And sugar content is low, it is suitable for multiple crowd and eats.
The present invention provides the preparation technology of the compositions of a kind of enhancing immunity and prophylactic treatment influenza, comprising:
Aqueous extraction step: Lepidinm meyenii Walp and Echinacea extract through ethanol water respectively and obtain Maca extract and Echinacea extraction
Thing；Radix Scutellariae, Radix Isatidis and Herba Houttuyniae carry through water respectively and obtain Radix Scutellariae extract, Radix Isatidis extract and Herba Houttuyniae extraction successively
Thing；Fructus Rosae Normalis is squeezed the juice, is concentrated to give Fructus Rosae Normalis extract；
Blend step: Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, Herba Houttuyniae are extracted
Thing and Fructus Rosae Normalis extract are mixed to prepare.
The activity composition of Lepidinm meyenii Walp and Echinacea, especially its energy enhancing immunity, the active substance of influenza are soluble in second
Alcohol.Meanwhile, ethanol is volatile, edible safety, extracts the ethanol extract active component obtained with ethanol water high, safety non-toxic.
In the present embodiment, Maca extract and Echinacea extract can the most commercially be commercially available, it is possible to
To use solvent extraction method that corresponding plant is extracted, concentrated.Preferably, Maca extract uses body at 60～70 DEG C
Fraction be 60～95% ethanol water extract, be concentrated to give.Echinacea extract uses volume integral at 60～70 DEG C
Number be 60～95% ethanol water extract, be concentrated to give.Wherein, Lepidinm meyenii Walp or Echinacea are equal with the solid-to-liquid ratio of ethanol water
For 1:5～15.Above-mentioned volume fraction be 60～95% ethanol water in the volume fraction of ethanol be 60～95%.Use second
Alcohol-water solution can effectively extract the active component in Lepidinm meyenii Walp and Echinacea, and extraction ratio is high, extracts the extract obtained and contains relatively
Many functional components.It is highly preferred that extraction time is 3 times, extract the active component in plant as much as possible, it is to avoid cause
Unnecessary waste.
In preferred embodiment of the present invention, Radix Scutellariae water boil extracts, Gu material ratio 1:5～15, extracts 3 times, is concentrated to give
Extractum, is Scutellaria baicalensis extract.Radix Isatidis water boil extracts, Gu material ratio 1:5～15, extracts 3 times, is concentrated to give extractum, is
Radix Isatidis extract.Herba Houttuyniae water boil extracts, Gu material ratio 1:5～15, extracts 3 times, is concentrated to give extractum, is Herba Houttuyniae and carries
Take thing.
In preferred embodiment of the present invention, choose Fructus Rosae Normalis fresh, ripe, clean, obtain Sucus Rosae Normalis after squeezing the juice, by Sucus Rosae Normalis
Concentrate and obtain Fructus Rosae Normalis extract for extractum.Preferably, thickening temperature is less than 50 DEG C, prevents vitamin C from aoxidizing.
When plant is extracted, in advance plant carried out drying and pulverize, being preferably and use nature dry in the shade or dry.
Drying plant under natural conditions, advantageously reduces the loss of active component in plant, for Lepidinm meyenii Walp, after drying
Lepidinm meyenii Walp in active component relatively low, influenza effect is the most weak.
In preferred embodiment of the present invention, the blend step of above-mentioned preparation technology also includes add adjuvant by compositions
It is prepared as the step of granule, powder, unguentum, tablet or capsule.Adjuvant is selected from starch, microcrystalline Cellulose and magnesium stearate
One or more.Granule, powder, unguentum, tablet or capsule these be all conventional pharmaceutical dosage form, its production technology
The most highly developed, it is easy to industrialized production, those skilled in the art can refer to conventional production process and are prepared.
The present invention provide the compositions of a kind of enhancing immunity and prophylactic treatment influenza preparation improve immunologic function and/
Or the purposes in the medicine of prophylactic treatment flu.
It addition, the compositions that the present invention provides a kind of enhancing immunity and prophylactic treatment influenza improves immunity merit in preparation
Purposes in the food of energy and/or prophylactic treatment flu.
Said composition is natural product, has and well improves immunologic function and effect of prophylactic treatment flu, permissible
For preparing medicine or food.
Embodiment 1
The present embodiment a kind of enhancing immunity of offer and the compositions of prophylactic treatment influenza, in parts by weight, including
Maca extract 35 parts, Scutellaria baicalensis extract 25 parts, Echinacea extract 15 parts, Radix Isatidis extract 15 parts, Herba Houttuyniae extract
10 parts, Fructus Rosae Normalis extract 8 parts and adjuvant 24 parts.Wherein, adjuvant includes starch 10 parts, microcrystalline Cellulose 10 parts, magnesium stearate 2
Part, xylitol 1 part and citric acid 1 part.
Above-mentioned composition is made as granule, and its preparation technology comprises the following steps:
Pulverize after drying for Lepidinm meyenii Walp, extract at 60～70 DEG C with the ethanol water that volume ratio mark is 60%～95%
3 times, the solid material of Lepidinm meyenii Walp and ethanol water obtains extractum than for being concentrated in vacuo at 1:5～5,50～60 DEG C, is Lepidinm meyenii Walp and extracts
Thing.Same method is used Echinacea to carry out ethanol water extraction, is concentrated to give Echinacea extract.
To pulverize after drying for Radix Scutellariae, boil extraction 3 times with pure water, the solid material of Radix Scutellariae and pure water ratio is for 1:5～15,50
～be concentrated in vacuo at 60 DEG C and obtain extractum, it is Radix Scutellariae extract.Same method is used Radix Isatidis and Herba Houttuyniae to be used respectively
Water boil extracts, is concentrated to give Radix Isatidis extract and Herba Houttuyniae extract.
Choose fresh, ripe Fructus Rosae Normalis, clean, squeeze the juice after obtain Sucus Rosae Normalis, by dense for Sucus Rosae Normalis vacuum at 40～50 DEG C
It is condensed to extractum, is Fructus Rosae Normalis extract.
Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, Herba Houttuyniae is taken according to said ratio
Extract and Fructus Rosae Normalis extract, add adjuvant, after each extract and adjuvant mix homogeneously, make granule, is dried, to obtain final product.
Embodiment 2
The present embodiment a kind of enhancing immunity of offer and the compositions of prophylactic treatment influenza, in parts by weight, including
Maca extract 45 parts, Scutellaria baicalensis extract 20 parts, Echinacea extract 10 parts, Radix Isatidis extract 20 parts, Herba Houttuyniae extract 5
Part, Fructus Rosae Normalis extract 10 parts and adjuvant 48 parts.Wherein, adjuvant includes starch 30 parts, microcrystalline Cellulose 10 parts, magnesium stearate 3
Part, Mel 2 parts, xylitol 2 parts and citric acid 1 part.
Above-mentioned composition is made as tablet, and its preparation technology comprises the following steps:
Obtain Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, fish as described in Example 1
Raw meat grass extract and Fructus Rosae Normalis extract.
Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, Herba Houttuyniae is taken according to said ratio
Extract and Fructus Rosae Normalis extract, add adjuvant, after each extract and adjuvant mix homogeneously, and granulation, granulate, tabletted, dry
Dry, to obtain final product.
Embodiment 3
The present embodiment a kind of enhancing immunity of offer and the compositions of prophylactic treatment influenza, in parts by weight, including
Maca extract 20 parts, Scutellaria baicalensis extract 30 parts, Echinacea extract 20 parts, Radix Isatidis extract 10 parts, Herba Houttuyniae extract
15 parts, Fructus Rosae Normalis extract 5 parts and adjuvant 16 parts.Wherein, adjuvant includes starch 10 parts, microcrystalline Cellulose 5 parts and stearic acid
1 part of magnesium.
Above-mentioned composition is made as capsule, and its preparation technology comprises the following steps:
Obtain Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, fish as described in Example 1
Raw meat grass extract and Fructus Rosae Normalis extract.
Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, Herba Houttuyniae is taken according to said ratio
Extract and Fructus Rosae Normalis extract, add adjuvant, after each extract and adjuvant mix homogeneously, is dried, loads capsule, to obtain final product.
Embodiment 4
The present embodiment a kind of enhancing immunity of offer and the compositions of prophylactic treatment influenza, in parts by weight, including
Maca extract 55 parts, Scutellaria baicalensis extract 25 parts, Echinacea extract 15 parts, Radix Isatidis extract 30 parts, Herba Houttuyniae extract
10 parts, Fructus Rosae Normalis extract 10 parts and adjuvant 37 parts.Wherein, adjuvant includes starch 20 parts, microcrystalline Cellulose 15 parts, magnesium stearate
1 part, malic acid 1 part.
Above-mentioned composition is made as powder, and its preparation technology comprises the following steps:
Obtain Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, fish as described in Example 1
Raw meat grass extract and Fructus Rosae Normalis extract.
Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, Herba Houttuyniae is taken according to said ratio
Extract and Fructus Rosae Normalis extract, add adjuvant, after each extract and adjuvant mix homogeneously, vacuum lyophilization, to obtain final product.
Embodiment 5
The present embodiment a kind of enhancing immunity of offer and the compositions of prophylactic treatment influenza, in parts by weight, including
Maca extract 15 parts, Scutellaria baicalensis extract 25 parts, Echinacea extract 5 parts, Radix Isatidis extract 15 parts, Herba Houttuyniae extract 12
Part, Fructus Rosae Normalis extract 5 parts and adjuvant 34 parts.Wherein, adjuvant includes starch 15 parts, microcrystalline Cellulose 15 parts, magnesium stearate 1
Part, Mel 2 parts and citric acid 1 part.
Above-mentioned composition is made as unguentum, and its preparation technology comprises the following steps:
Obtain Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, fish as described in Example 1
Raw meat grass extract and Fructus Rosae Normalis extract.
Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, Herba Houttuyniae is taken according to said ratio
Extract and Fructus Rosae Normalis extract, add adjuvant, after each extract and adjuvant mix homogeneously, to obtain final product.
Embodiment 6
The present embodiment a kind of enhancing immunity of offer and the compositions of prophylactic treatment influenza, in parts by weight, including
Maca extract 30 parts, Scutellaria baicalensis extract 15 parts, Echinacea extract 30 parts, Radix Isatidis extract 5 parts, Herba Houttuyniae extract 20
Part and Fructus Rosae Normalis extract 15 parts.
Above-mentioned composition is made as unguentum, and its preparation technology comprises the following steps:
Obtain Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, fish as described in Example 1
Raw meat grass extract and Fructus Rosae Normalis extract.
Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, Herba Houttuyniae is taken according to said ratio
Extract and Fructus Rosae Normalis extract, mix homogeneously, to obtain final product.
Embodiment 7
The present embodiment a kind of enhancing immunity of offer and the compositions of prophylactic treatment influenza, in parts by weight, including
Maca extract 35 parts, Scutellaria baicalensis extract 25 parts, Echinacea extract 15 parts, Radix Isatidis extract 15 parts, Herba Houttuyniae extract
10 parts and Fructus Rosae Normalis extract 8 parts.
Above-mentioned composition is made as unguentum, and its preparation technology comprises the following steps:
Obtain Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, fish as described in Example 1
Raw meat grass extract and Fructus Rosae Normalis extract.
Maca extract, Echinacea extract, Radix Scutellariae extract, Radix Isatidis extract, Herba Houttuyniae is taken according to said ratio
Extract and Fructus Rosae Normalis extract, mix homogeneously, to obtain final product.
Test example 1 Lepidinm meyenii Walp ethanol extract resisiting influenza virus experiment in vitro
Test material: Lepidinm meyenii Walp ethanol extract, mdck cell (Madin-Darby canine kidney(cell line) (MDCK)), influenza A virus (Flu～A), influenza B
Virus (Flu～B).
Test method:
Measure the anti-A type type influenza virus ability of Lepidinm meyenii Walp ethanol extract: with maintaining liquid virus dilution Flu-A, pass by 10 times
Subtract, virus stock solution used and each concentration viral dilution liquid are joined inoculation mdck cell and has grown up to 96 well culture plates of monolayer
In, at 5%CO at 37 DEG C2Incubator is hatched, and observes CPE (cytopathy), and presses Reed-Muench method calculating TCID50 (half
Number infective dose).Take inoculation mdck cell and grown up to 96 well culture plates of monolayer, inhaling and abandon culture fluid, with 100 times of TCID50
Virus liquid infect mdck cell, put 5%CO at 37 DEG C2Incubator adsorbs 2h.Maca extract maintenance liquid is diluted to 0
μ g/mL, 10 μ g/mL, 20 μ g/mL, 40 μ g/mL, 60 μ g/mL, 80 μ g/mL totally 6 concentration, add the Lepidinm meyenii Walp ethanol extract of each concentration
Enter in the mdck cell infecting virus, continue to cultivate 3 days, observation of cell survival rate.
Measure the anti-B-mode type influenza virus ability of Lepidinm meyenii Walp ethanol extract: test method is ibid.
Result of the test is shown in Table 1, and the In vitro antibacterial test result of Lepidinm meyenii Walp ethanol extract shows, the ethanol extract of Lepidinm meyenii Walp is to A type stream
Influenza Virus (Flu-A) and Influenza B virus (Flu-B) all have preferable antiviral effect, and along with Lepidinm meyenii Walp ethanol extract concentration
Rising, cell survival rate is gradually increased, and the Lepidinm meyenii Walp ethanol extract of high dose concentration makes cell survival rate reach more than 80%, shows agate
Coffee ethanol extract has strong resisiting influenza virus ability, can be applicable to prevention and treats grippal health product or medicine.
Table 1 Lepidinm meyenii Walp ethanol extract antivirus test result
*p<0.05。
The compositions resisiting influenza virus experiment in vitro that test example 2 embodiment of the present invention 7 provides
Test material: the compositions of the embodiment of the present invention 7 offer, mdck cell (Madin-Darby canine kidney(cell line) (MDCK)), influenza A virus
(Flu～A), Influenza B virus (Flu～B).
Test method:
Measure the anti-A type type influenza virus ability of the compositions that the embodiment of the present invention 7 provides: with maintaining liquid virus dilution
Flu-A, successively decreases by 10 times, virus stock solution used and each concentration viral dilution liquid joins inoculation mdck cell and has grown up to monolayer
96 well culture plates in, at 5%CO at 37 DEG C2Incubator is hatched, and observes CPE (cytopathy), and based on Reed-Muench method
Calculate TCID50 (50 3nfective dose).Take inoculation mdck cell and grown up to 96 well culture plates of monolayer, inhaling and abandon culture fluid, using
The virus liquid of 100 times of TCID50 infects mdck cell, puts 5%CO at 37 DEG C2Incubator adsorbs 2h.By the embodiment of the present invention 7
The compositions maintenance liquid provided is diluted to 0 μ g/mL, 10 μ g/mL, 20 μ g/mL, 40 μ g/mL, 60 μ g/mL, 80 μ g/mL totally 6
Concentration, joins in the mdck cell infecting virus by the maca composition of each concentration, continues to cultivate 3 days, and observation of cell is deposited
Motility rate.
Measure the anti-B-mode type influenza virus ability of the compositions that the embodiment of the present invention 7 provides: test method is ibid.
Result of the test is shown in Table 2, and the In vitro antibacterial test result of the compositions that the embodiment of the present invention 7 provides shows, this
Influenza A virus (Flu-A) and Influenza B virus (Flu-B) are all had the most disease-resistant by the compositions that bright embodiment 7 provides
Toxic effect fruit, and along with the rising of said composition concentration, cell survival rate is gradually increased, the said composition of high dose concentration makes cell
Survival rate reaches more than 85%, and display said composition resisiting influenza virus ability is better than Lepidinm meyenii Walp ethanol extract, can be applicable to prevention and controls
Treat grippal health product or medicine.
The compositions antivirus test result that table 2 embodiment of the present invention 7 provides
*p<0.05。
Test example 3
Choose 50 cold patients, age 18～60 years old, male 30, women 20.It is influenza after diagnosing, flat
The most concurrent 1～2 day, cold symptoms: have a fever more than 37.5 DEG C, with breathe all symptom, fear of cold, have a headache, feel sick, bitter taste is tasteless,
Anorexia, extremity are aching and limp, yellowish or reddish urine.
Instructions of taking: the tablet (every is about 0.5g) that embodiment 1 method prepares, three times a day, each 3, Wen Kai
Water delivery service.
Evaluation index: cure: symptom all disappears；Effective: symptom is substantially alleviated, bring down a fever the most completely；Effective: symptom has
Alleviated, significant hypothermal of such as having a fever；Invalid: symptom does not change.
Statistical effect: observe after taking three days, in whole 50 cold patients, cures 39 people, cure rate 78%, and effective 6
People, accounts for 12%, is effectively 5 people, accounts for 10%.
All cold patients's the most acomia existing any discomfort symptom in taking, in follow-up observation, finds that major part is suffered from
The flu convalescent period of person within 3～4 days, and after bringing down a fever the symptom such as respiratory symptom and weak, inappetence all in 1～2
Take a turn for the better completely.
Case 1
Summer, male, 33 years old, influenza: acute high fever, flush, develop signs of a cold.Take of the present invention group
Compound was brought down a fever in 1 day, and after 3～4 days, cold symptoms is completely eliminated.
Case 2
Deng, women, 28 years old, influenza: body temperature is increased to 39.1 DEG C, headache, malaise.Take the present invention
Compositions 2 days, cold symptoms is alleviated, and has a headache and takes a turn for the better, and after 4 days, cold symptoms is completely eliminated.
Case 3
Zhang, man, 29 years old, overtime work of often staying up late, body constitution was poor, suffers from influenza one week, and plate muscular soreness is tired
The general malaise symptoms such as unable, inappetence, take Western medicine a few days symptom without substantially alleviating.Take the present composition 3 subsequently
After it, symptom is substantially alleviated, and general malaise symptom alleviates, and continues to take two days later, recovery from illness.
Case 4
Zhao so-and-so, female, 46 years old, the most overworked cause body constitution more weak, annual spring and winter all can suffer from popular sexuality
Emit 2～3 times, at least need within two weeks, could fully recover after flu every time.The present composition was taken, clothes after suffering from influenza winter last year
Threw off a cold after 4 days.Adhering to that every day takes this product afterwards, the immunity ability of 1 year subsequently health obtains bigger enhancing,
And suffer from influenza the most again.
In sum, the compositions that the present invention provides has obvious immunomodulating effect, it is possible to strengthen the immunity of human body
Power, containing multiple antiviral, antibacterial, the effective ingredient of increase immunity in compositions, it is possible to strengthen the immunity of human body, promote
The human body resistance to poisonous and harmful substance, has the most excellent effect for prevention and treatment influenza.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's
May be made that in the case of spirit and scope many other change and amendment.It is, therefore, intended that in the following claims
Including all such changes and modifications belonged in the scope of the invention.
Claims (10)
1. an enhancing immunity and the compositions of prophylactic treatment influenza, it is characterised in that in parts by weight, described combination
Thing includes: Maca extract 15～55 parts, Scutellaria baicalensis extract 15～40 parts, Echinacea extract 5～30 parts, Radix Isatidis extract
5～30 parts, Herba Houttuyniae extract 5～20 parts and Fructus Rosae Normalis extract 5～15 parts.
Enhancing immunity the most according to claim 1 and the compositions of prophylactic treatment influenza, it is characterised in that according to weight
Number meter, described Maca extract is 20～45 parts, and described Scutellaria baicalensis extract is 20～30 parts, and described Echinacea extract is 10
～20 parts, described Radix Isatidis extract is 10～20 parts, and described Herba Houttuyniae extract is 5～15 parts, and described Fructus Rosae Normalis extract is 5
～10 parts.
Enhancing immunity the most according to claim 1 and the compositions of prophylactic treatment influenza, it is characterised in that described enhancing
The compositions of immunity and prophylactic treatment influenza also includes adjuvant, described adjuvant selected from starch, microcrystalline Cellulose, magnesium stearate with
And one or more of correctives, in parts by weight, described starch 10～30 parts, described microcrystalline Cellulose 5～15 parts, institute
State magnesium stearate 1～3 parts, described correctives 0～5 parts.
Enhancing immunity the most according to claim 1 and the compositions of prophylactic treatment influenza, it is characterised in that described Lepidinm meyenii Walp
Extract is the ethanol extract of Lepidinm meyenii Walp, and described Echinacea extract is the ethanol extract of Echinacea, and described Radix Scutellariae extract is Radix Scutellariae
Water extract, described Radix Isatidis extract is the water extract of Radix Isatidis, and described Herba Houttuyniae extract is the water extract of Herba Houttuyniae.
5. a preparation technology for the compositions of enhancing immunity according to claim 1 and prophylactic treatment influenza, it is special
Levy and be, comprising:
Extraction step: Lepidinm meyenii Walp and Echinacea extract through ethanol water respectively and obtain described Maca extract and described Echinacea carries
Take thing；Radix Scutellariae, Radix Isatidis and Herba Houttuyniae carry through water respectively and obtain described Radix Scutellariae extract, described Radix Isatidis extract and institute successively
State Herba Houttuyniae extract；Described Fructus Rosae Normalis is squeezed the juice, is concentrated to give described Fructus Rosae Normalis extract；
Blend step: described Maca extract, described Echinacea extract, described Radix Scutellariae extract, described Radix Isatidis are extracted
Thing, described Herba Houttuyniae extract and described Fructus Rosae Normalis extract are mixed to prepare.
The preparation technology of the compositions of enhancing immunity the most according to claim 5 and prophylactic treatment influenza, its feature exists
In, described Lepidinm meyenii Walp use at 60～70 DEG C volume fraction be 60～95% ethanol water extract, be concentrated to give described agate
Coffee extract；Described Echinacea use at 60～70 DEG C volume fraction be 60～95% ethanol water extract, be concentrated to give
Solid-to-liquid ratio to described Echinacea extract, described Lepidinm meyenii Walp and described Echinacea Yu described ethanol water is 1:5～15.
7. according to the enhancing immunity described in claim 5 or 6 and the preparation technology of the compositions of prophylactic treatment influenza, its feature
Being, described Radix Scutellariae water boil extracts, is concentrated to give described Radix Scutellariae extract；Described Radix Isatidis water boil extracts, concentrates
Obtain described Radix Isatidis extract；Described Herba Houttuyniae water boil extracts, is concentrated to give described Herba Houttuyniae extract；Described Huang
A kind of reed mentioned in ancient books, described Radix Isatidis and described Herba Houttuyniae are 1:5～15 with the solid-to-liquid ratio of described water.
The preparation technology of the compositions of enhancing immunity the most according to claim 5 and prophylactic treatment influenza, its feature exists
In, described blend step also including, adding adjuvant is prepared as granule, powder, unguentum, tablet or glue by described compositions
The step of wafer；Described adjuvant is selected from one or more of starch, microcrystalline Cellulose and magnesium stearate.
9. improve in preparation according to the compositions of the enhancing immunity described in claim 1-4 any one and prophylactic treatment influenza
Purposes in the medicine of immunologic function and/or prophylactic treatment flu.
10. carry in preparation according to the compositions of the enhancing immunity described in claim 1-4 any one and prophylactic treatment influenza
Purposes in the food of high immunologic function and/or prophylactic treatment flu.
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