CN106074436A - A kind of method utilizing starch matrix to make heat molten type capsule material - Google Patents

Abstract

The invention discloses a method for making hot-melt capsules by using starch as the main raw material of a substrate. The method uses starch as the main material, gelatin and glycerin as auxiliary materials. After dilution, stirring, and ultrasonication, a colloidal wall material is formed. The core material is injected under low temperature conditions, coated to form a capsule material, and washed with ethanol to form a hot flue gas that can be heated above 50°C. Capsule material that melts under conditions. The hot-melt capsule material can be used in combustion, hot gas, thermal catalysis and similar temperature conditions to release specific coating liquid. The method is simple to operate, has wide sources of raw materials, and is safe and environment-friendly.

Description

A method of making hot-melt capsule material by using starch matrix

technical field

The invention discloses a method for making hot-melt capsules by using starch as the main raw material of a matrix. The method uses starch as the main material, gelatin and glycerin as auxiliary materials. After dilution, stirring, and ultrasonication, a colloidal wall material is formed. The core material is injected under low temperature conditions, coated to form a capsule material, and washed with ethanol to form a gel that can be melted under hot flue gas conditions. capsule material. The invention belongs to the field of light industry.

Background technique

In the 1990s, the research on starch-modified film materials based on starch has made rapid progress, and the research on starch films is mainly for packaging and medical coatings. The composite research or development of starch and other materials includes shell starch-polysaccharide film, sterol film, protein film, etc. Since 2012, starch-based capsules for pharmaceutical packaging have been developed successively, but there are few technological or commercial success stories. However, the preparation of capsule products based on starch is still the most promising development direction.

Hot-melt capsule material is suitable for hot air or hot smoke at a temperature above 50°C. The structure of the capsule wall material changes from dense to loose, the mechanical strength decreases, and the permeability increases rapidly, and the coated core material can seep out. . It can be used to coat liquid core materials, and is suitable for use under conditions that require core materials to bleed out in specific occasions, such as combustion, hot gas, thermal catalysis and other similar conditions.

Contents of the invention

The purpose of the present invention is to provide a method for making a hot-melt capsule material using starch as the main raw material for releasing a specific coating liquid under combustion, thermal catalysis and similar temperature conditions. The method is simple to operate, has wide sources of raw materials, and is safe and environment-friendly.

The purpose of the present invention is achieved by the following technical methods:

A. With starch as the main material, gelatin and glycerin as auxiliary materials, dilute with water, stir, heat at a constant temperature, and obtain the colloidal wall material mother liquor after ultrasonication;

B. The colloidal wall material mother liquor is placed in a low temperature environment;

C. Put the core material in a needle-hole syringe, inject the core material into the low-temperature colloid wall material mother liquor quantitatively and at a constant speed, so that the wall material is coated with the core material to form a coated capsule material, and the core material can be extracted or retained;

D. Wash the coated capsule material with ethanol solution to make a hot-melt capsule material.

The starch includes corn starch, potato starch, konjac starch, sweet potato starch, pea starch and modified starches.

The ratio of the starch to the gelatin is 3:2-4:1.

The ratio of the gelatin to glycerin is 3:2-4:1.

The ratio of the main and auxiliary materials to water is 1:10~2:9.

The heating method of the constant temperature heating is one or more of water bath, electric heating, and fire heating, and the temperature is 56°C~80°C.

The ultrasonic power is 20w~50w.

The temperature of the low temperature environment is -2°C to 16°C.

The core material is liquid or semi-solid lipid or fat-soluble substance.

The ethanol solution includes ethanol or its substitute methanol solution, and its volume fraction is 80%~100%.

The beneficial effect of the invention is that it can obtain a method for making a hot-melt capsule material by using starch as the main matrix. The method is simple in operation, low in raw material cost, safe and environment-friendly.

The parameters, process steps and operation rules of the present invention interact to form a complete technical scheme.

detailed description

The following examples are used to illustrate the present invention and make it more specific, but in no way limit the scope of the present invention.

Example 1

Step 1: Weigh 4 parts of cornstarch, 2 parts of gelatin, and 1 part of glycerin according to the mass fraction, dilute with 93 parts of water, stir, bathe in 75°C water for 30 minutes, and degas with 35w ultrasonic for 5 minutes to obtain the wall material mother liquor;

Step 2: The colloidal wall material mother solution is placed in a low temperature environment of 5°C, and equilibrated for 20 minutes;

Step 3: put sesame oil in the syringe as the core material, and inject it into the colloidal 5°C wall material mother liquor in the form of dewdrops, and the mother liquor is coated with dewdrops to form a coated capsule material;

Step 4: The coated capsule material is washed with 95% ethanol solution to obtain a starch-based hot-melt capsule material.

Example 2

Step 1: Weigh 5 parts of cornstarch, 2 parts of gelatin, and 2 parts of glycerin according to the mass fraction, dilute with 91 parts of water, stir, bathe in 70°C water for 30 minutes, and degas with 35w ultrasonic for 5 minutes to obtain the wall material mother liquor;

Step 2: The colloidal wall material mother solution is placed in a low-temperature environment at 2°C, and equilibrated for 20 minutes;

Step 3: Put the liquid paraffin wax in the syringe as the core material, inject it into the mother liquor of the colloidal wall material in the form of dewdrops, the mother liquor is coated with dew drops to form the coated capsule material, and the coated capsule material is released, and the coated capsule material is released with a No. 5 injection needle. Extract the liquid paraffin to obtain the capsule material;

Step 4: The capsule material is washed twice with 95% ethanol solution to obtain a starch-based hot-melt capsule material.

Fig. 1 is the method that utilizes starch matrix to make hot-melt type capsule material.

Claims (9)

1. A method utilizing starch matrix to make hot-melt type capsule material, is characterized in that following steps: (A) Use starch as the main material, gelatin and glycerin as auxiliary materials, dilute with water, stir, heat at a constant temperature, and obtain the mother liquor of the colloidal wall material after ultrasonication; (B) place the mother liquor of the colloidal wall material in a low temperature environment; (C) put the core material Put it in a needle-hole syringe, inject the core material into the low-temperature colloid wall material mother liquor at a fixed rate, so that the wall material is coated with the core material to form a coated capsule material, and the core material can be extracted or retained; (D) Coated capsule The material is washed with ethanol solution to make hot-melt capsule material. 2. The starch according to claim 1. (A) includes but is not limited to one or more of corn starch, potato starch, konjac starch, sweet potato starch, pea starch and modified starches, and the present invention is not limited to The above example range. 3. According to claim 1. The starch described in (A) is the main material, gelatin and glycerin are the auxiliary materials, and the ratio of starch to gelatin is 3:2~4:1. 4. starch according to claim 3 is main ingredient, and gelatin and glycerin are auxiliary materials, and the ratio of gelatin and glycerin is 3:2～4:1. 5. The constant temperature heating according to claim 1. (A), the heating method is one or more of water bath, electric heating, fire heating, but not limited to the above heating methods, and the temperature is 56°C~80°C. 6. According to claim 1. (B), the colloidal wall material mother liquid is placed in a low temperature environment, and its temperature is -2°C~16°C. 7. According to claim 1. (C), the core material is placed in the needle-hole syringe, and the core material is liquid or semi-solid lipid or fat-soluble substance. 8. The coated capsule material according to claim 1. (D) is washed with ethanol solution, and the volume fraction of ethanol is 80%~100%. 9. The coated capsule material according to claim 8 is washed with ethanol, wherein ethanol includes one or a mixture of ethanol and methanol.