[go: up one dir, main page]

CN106073947A - Heart volume reduction system - Google Patents

Heart volume reduction system Download PDF

Info

Publication number
CN106073947A
CN106073947A CN201610747851.1A CN201610747851A CN106073947A CN 106073947 A CN106073947 A CN 106073947A CN 201610747851 A CN201610747851 A CN 201610747851A CN 106073947 A CN106073947 A CN 106073947A
Authority
CN
China
Prior art keywords
rod
volume reduction
reduction system
skeleton
heart volume
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610747851.1A
Other languages
Chinese (zh)
Inventor
关丽鹃
钱永巍
周叶
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suzhou Lainuo Medical Devices Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610747851.1A priority Critical patent/CN106073947A/en
Publication of CN106073947A publication Critical patent/CN106073947A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2478Passive devices for improving the function of the heart muscle, i.e. devices for reshaping the external surface of the heart, e.g. bags, strips or bands
    • A61F2/2487Devices within the heart chamber, e.g. splints
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0093Umbrella-shaped, e.g. mushroom-shaped

Landscapes

  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Prostheses (AREA)

Abstract

The invention discloses a kind of heart volume reduction system, guidance system, volume reduction system includes multi-rod skeleton, multi-rod skeleton is made up of multiple brace rods, each brace rod top has barb to be formed, turn up formation peviform along surrounding in brace rod top, brace rod surface is covered with macromolecule isolating membrane, fix one bottom multi-rod skeleton and support pedestal, guidance system includes metallic rod and the protection set being wholely set, protection is set in the outside of metallic rod, metallic rod can slidably reciprocate in protection set, the top of metallic rod is connected with supporting pedestal, support pedestal and use Thermoplastic polyurethane elastomer material, it is internal that metallic rod can drive support pedestal and multi-rod skeleton to slide to protection set.By capacity-reduction device is housed in guidance system, penetrates on left ventricle surface and heart volume reduction system is delivered in human heart, be implanted in heart, by the compartmentation of capacity-reduction device, reduce ventricular volume, reduce ventricle tension force, improve the cardiac function of remodeling ventricle and patient.

Description

Heart volume reduction system
Technical field
The present invention relates to medical field, particularly relate to a kind of therapeutic medical heart volume reduction system.
Background technology
Heart failure has become the healthy heavy burden in the whole world, and whole world heart failure patient there are about 26,000,000 at present, and prevalence is 1-2%.More than 70 years old crowd's heart failure prevalence >=10% of American-European countries.In the heart failure patient course of disease of 74% at least one Complication, this type of patient is easier to occur the deterioration of disease, causes admission rate and mortality rate to remain high again.Advanced heart failure prognosis More worse than part entity tumor and myocardial infarction, 5 annual survival rates of severe patient are less than 20%.Heart failure brings for society simultaneously Huge financial burden.
In recent years, being paid attention to by clinic more and more, it main reason is that it becomes whole world morbidity and dead head Want one of inducement, even and if calcification score technology development widely available instantly, still have 20%~50% myocardial infarction patient Can transfer heart failure patient to, and left ventricle geometry is as one of the main prognosis of heart failure, particularly myocardial ischemia Heart geometry can be changed.Three coronary artery are easiest to myocardial infarction occur with anterior descending branch especially, the antetheca that result causes , there is apex impaired movement even ventricular aneurysm in large area infarction, increases the weight of remodeling ventricle further and CHF occurs Symptom.After acute anterior wall myocardial infarction patients, myocardial necrosis and scarring subsequently, cause left ventricular remodeling, causes left ventricle dilation and a left side Ventricular systolic function declines.The important symbol of remodeling ventricle is exactly wall tension change and heart volume change.Therefore machinery The minimizing bulk of left ventricle of property can alleviate wall tension thus improve remodeling ventricle, here it is the theory of surgery partial left ventriculectomy depends on According to.Though the history in partial left ventriculectomy existing more than 50 years, surgery operating wound is relatively big, and to the requirement of surgery patient relatively Height makes clinical practice limited.
Summary of the invention
For overcoming disadvantages mentioned above, it is an object of the invention to provide and a kind of heart failure can be carried out the medical of insertion type treatment Heart volume reduction system.
In order to reach object above, the technical solution used in the present invention is: a kind of heart volume reduction system, fills including volume reduction Putting, described capacity-reduction device includes that multi-rod skeleton, described multi-rod skeleton are made up of multiple brace rods, brace rod described in each two Between have fixed angle, each described brace rod top to be formed with barb, turn up formation peviform along surrounding in described brace rod top, Described brace rod surface is covered with macromolecule isolating membrane, and described multi-rod skeleton can shrink, and fixes one bottom described multi-rod skeleton Individual support pedestal, described heart volume reduction system also include metallic rod that guidance system, described guidance system include being wholely set and Protection set, described protection set uses macromolecular material, and described protection set is set in the outside of metallic rod, and described metallic rod can protected Slidably reciprocating in sheath, the top of described metallic rod is connected with supporting pedestal, and described support pedestal uses thermoplastic polyurethane bullet Elastomer material, it is internal that described metallic rod can drive support pedestal and multi-rod skeleton to slide to protection set.
Heart volume reduction system of the present invention provides the benefit that, barb plays fixation at cardiac muscle, prevents the dress after release Put and be moved, stability and the intensity of heart volume reduction system can be effectively improved;Guidance system uses macromolecular material or gold Belong to material, there is preferable propelling movement ability.Heart volume reduction system can be by puncturing mode, specifically by volume reduction being filled Put and be housed in guidance system, penetrate on left ventricle surface and heart volume reduction system is delivered in human heart, be implanted in heart In, capacity-reduction device operates by guidance system, sliding opening capacity-reduction device, by use multi-rod skeleton and isolating membrane Compartmentation, effectively reduces ventricular volume, reduces ventricle tension force, improves the cardiac function of remodeling ventricle and patient.Overcome existing The elastic performance of wadding is poor, cardiac stimulus inner chamber;And the shortcoming that existing wadding structure stimulates the apex of the heart etc..Heart volume reduction system System fix and fit in heart by surface barb in heart inner cavity position, particularly cardiac lumen owing to disease is in irregularly Shape, is prevented effectively from cardiac stimulus inner chamber, and the fixing pedestal that supports uses Thermoplastic polyurethane elastomer material simultaneously, can protect the heart Point is not damaged, and utilizes the separation of isolating membrane, stops blood to flow into the apex of the heart, plays plugging action.Many by capacity-reduction device Rod-type skeleton from swollen at cardiac lumen, effectively reduce ventricular volume, and reduces ventricle tension force, to reach to improve remodeling ventricle and trouble The therapeutic purposes of the cardiac function of person;The metallic rod of guidance system and protection set unitary design, conveniently operate and exit heart.
Preferably, described multi-rod skeleton is by can making from swollen Nitinol.Niti material has Memorability and superlastic Property characteristic, be effectively improved the size restoration of bracing frame and overall compliance, more effectively avoid cardiac stimulus inner chamber.
Preferably, a diameter of the 60~120mm of capacity-reduction device;Can effectively cover most patient demand.
Preferably, the quantity of described brace rod is 12-25, and fixed angle between brace rod described in each two be 15 °- 30°。
Preferably, described macromolecule isolating membrane is electricity textile polymer.This material has good biocompatibility, controls Biological interaction and specialty filtering medium, and without or less fluid seepage performance, play the effect effectively blocked and isolate.
Preferably, described support pedestal and the type of attachment of capacity-reduction device be hot jet welding or UV optical cement bonding.Improve the heart The stability that dirty volume reduction system is overall.
Preferably, described brace rod top turns up 40 °-50 ° along surrounding.
Preferably, a length of 1.5-3mm of described barb.
Preferably, described multi-rod skeleton and macromolecule isolating membrane use suture way combination fixing.This mode can make Isolating membrane is effectively fixed on multi-rod skeleton and improves the support force of multi-rod skeleton.
Preferably, described support pedestal is formed in one with multi-rod skeleton.Seamless compartmentation can be played, improve heart The structural stability that volume reduction system is overall, without dropping risk.
Accompanying drawing explanation
Fig. 1 is the structural representation after the release of heart volume reduction system;
Fig. 2 is heart volume reduction system top view;
Fig. 3 is the top view after the release of multi-rod skeleton;
Fig. 4 is the structural representation before guidance system release;
Fig. 5 is the structural representation after guidance system exits heart.
In figure:
1-capacity-reduction device;2-guidance system;3-brace rod;4-isolating membrane;5-supports pedestal;6-barb;7-multi-rod bone Frame;8-metallic rod;9-protects set.
Detailed description of the invention
Below in conjunction with the accompanying drawings presently preferred embodiments of the present invention is described in detail, so that advantages and features of the invention energy It is easier to be readily appreciated by one skilled in the art, thus protection scope of the present invention is made apparent clear and definite defining.
Seeing shown in accompanying drawing 1-5, a kind of heart volume reduction system in the present embodiment, including capacity-reduction device 1, capacity-reduction device 1 Including multi-rod skeleton 7, multi-rod skeleton 7 uses can be from swollen nickel-titanium alloy material, and multi-rod skeleton 7 is by multiple brace rods 3 Constitute, brace rod 3 quantity be the fixed angle between 12-25, and each two brace rod 3 be 15 °-30 °, each brace rod 3 pushes up Portion is formed with the barb 6 of a length of 1.5-3mm, turns up formation peviform along surrounding in brace rod 3 top, formed a diameter of 60~ 120mm, brace rod 3 top turns up 40 °-50 ° along surrounding, and brace rod 3 surface is covered with macromolecule isolating membrane 4, multi-rod skeleton 7 energy Shrinking, fix one and support pedestal 5 bottom multi-rod skeleton 7, heart volume reduction system also includes that guidance system 2, guidance system 2 wrap Including the metallic rod 8 being wholely set and protection set 9, protection set 9 use macromolecular material, protection set 9 is set in outside metallic rod 8 Portion, metallic rod 8 can slidably reciprocate in protection set 9, and the top of metallic rod 8 is connected with supporting pedestal 5, supports pedestal 5 and uses heat Plastic polyurethane elastomeric material, it is internal that metallic rod 8 can drive support pedestal 5 and multi-rod skeleton 7 to slide to protection set 9.
Macromolecule isolating membrane 4 is electricity textile polymer.
Support pedestal 5 and the type of attachment of capacity-reduction device 1 be hot jet welding or UV optical cement bonding.
Multi-rod skeleton 7 and macromolecule isolating membrane 4 use suture way combination fixing.
The fixing pedestal 5 that supports is formed in one with multi-rod skeleton 7.
Embodiment of above only for technology design and the feature of the present invention are described, its object is to allow and is familiar with technique People understands present disclosure and is carried out, and can not limit the scope of the invention with this, all according to present invention spirit The equivalence that essence is done changes or modifies, and all should contain within the scope of the present invention.

Claims (10)

1. a heart volume reduction system, including capacity-reduction device (1), described capacity-reduction device (1) includes multi-rod skeleton (7), described Multi-rod skeleton (7) is made up of multiple brace rods (3), has fixed angle between brace rod described in each two (3), each described Support muscle (3) top is formed with barb (6), and turn up formation peviform along surrounding in described brace rod (3) top, described brace rod (3) table Face is covered with macromolecule isolating membrane (4), and described multi-rod skeleton (7) can be shunk, and described multi-rod skeleton (7) bottom fixes one Support group seat (5), it is characterised in that: described heart volume reduction system also includes that guidance system (2), described guidance system (2) include one (9) are overlapped in metallic rod (8) and protection that body is arranged, and described protection set (9) uses macromolecular material, and described protection set (9) is set in The outside of metallic rod (8), described metallic rod (8) can protection set (9) in slidably reciprocate, the top of described metallic rod (8) with Support group seat (5) connects, and described support pedestal (5) uses Thermoplastic polyurethane elastomer material, and described metallic rod (8) can drive props up It is internal that support group seat (5) and multi-rod skeleton (7) slide to protection set (9).
Heart volume reduction system the most according to claim 1, it is characterised in that: described multi-rod skeleton (7) is by can be from swollen nickel Titanium alloy is made.
Heart volume reduction system the most according to claim 1, it is characterised in that: a diameter of the 60~120mm of capacity-reduction device (1).
Heart volume reduction system the most according to claim 1, it is characterised in that: the quantity of described brace rod (3) is 12-25, and Fixed angle between brace rod described in each two (3) is 15 °-30 °.
Heart volume reduction system the most according to claim 1, it is characterised in that: described macromolecule isolating membrane (4) is that electrospinning is knitted poly- Compound.
Heart volume reduction system the most according to claim 1, it is characterised in that: described support pedestal (5) and capacity-reduction device (1) Type of attachment be hot jet welding or UV optical cement bonding.
Heart volume reduction system the most according to claim 1, it is characterised in that: turn up along surrounding in described brace rod (3) top 40°-50°。
8. according to claim 1 heart volume reduction system, it is characterised in that: a length of 1.5-3mm of described barb (6).
9. according to claim 1 heart volume reduction system, it is characterised in that: multi-rod skeleton (7) uses with macromolecule isolating membrane (4) Suture way combination is fixing.
10. according to claim 1 heart volume reduction system, it is characterised in that: described support pedestal (5) with multi-rod skeleton (7) is One-body molded.
CN201610747851.1A 2016-08-29 2016-08-29 Heart volume reduction system Pending CN106073947A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610747851.1A CN106073947A (en) 2016-08-29 2016-08-29 Heart volume reduction system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610747851.1A CN106073947A (en) 2016-08-29 2016-08-29 Heart volume reduction system

Publications (1)

Publication Number Publication Date
CN106073947A true CN106073947A (en) 2016-11-09

Family

ID=57224266

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610747851.1A Pending CN106073947A (en) 2016-08-29 2016-08-29 Heart volume reduction system

Country Status (1)

Country Link
CN (1) CN106073947A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109009589A (en) * 2018-08-22 2018-12-18 湖南埃普特医疗器械有限公司 A kind of ventricle capacity-reduction device and its transportation system
CN112294494A (en) * 2020-08-18 2021-02-02 上海竑宇医疗科技有限公司 Ring retractor and mounting method thereof
CN118105114A (en) * 2024-01-29 2024-05-31 中国人民解放军空军军医大学 A ventricular assist device that can be used for ventricular aneurysm

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090192539A1 (en) * 2003-07-16 2009-07-30 Kardium Inc. Methods and Devices for altering blood flow through the left ventricle
US20130165735A1 (en) * 1999-08-09 2013-06-27 Alexander Khairkhahan System for improving cardiac function by sealing a partitioning membrane within a ventricle
CN103800045A (en) * 2014-02-24 2014-05-21 梅奇峰 Medical cardiac tamponade object
CN104042300A (en) * 2013-03-14 2014-09-17 卡迪欧凯尼迪克斯公司 Systems and methods for making a laminar ventricular partitioning device
US20140296624A1 (en) * 2009-10-26 2014-10-02 James R. Kermode Ventricular volume reduction
CN104706444A (en) * 2015-03-03 2015-06-17 上海形状记忆合金材料有限公司 Volume reduction device for left ventricle
WO2015116562A1 (en) * 2014-01-28 2015-08-06 St. Jude Medical, Cardiology Division, Inc. Medical device with a packaged electronic subassembly and method for fabricating the same
CN105407822A (en) * 2013-07-26 2016-03-16 火山公司 Connection structures for intravascular devices and associated systems and methods
CN105476733A (en) * 2016-01-27 2016-04-13 张刚成 Heart volume reduction device
CN105792877A (en) * 2013-09-30 2016-07-20 比尔卡地亚股份有限公司 Radial and Transendocardial Delivery Catheters

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130165735A1 (en) * 1999-08-09 2013-06-27 Alexander Khairkhahan System for improving cardiac function by sealing a partitioning membrane within a ventricle
US20090192539A1 (en) * 2003-07-16 2009-07-30 Kardium Inc. Methods and Devices for altering blood flow through the left ventricle
US20140296624A1 (en) * 2009-10-26 2014-10-02 James R. Kermode Ventricular volume reduction
CN104042300A (en) * 2013-03-14 2014-09-17 卡迪欧凯尼迪克斯公司 Systems and methods for making a laminar ventricular partitioning device
CN105407822A (en) * 2013-07-26 2016-03-16 火山公司 Connection structures for intravascular devices and associated systems and methods
CN105792877A (en) * 2013-09-30 2016-07-20 比尔卡地亚股份有限公司 Radial and Transendocardial Delivery Catheters
WO2015116562A1 (en) * 2014-01-28 2015-08-06 St. Jude Medical, Cardiology Division, Inc. Medical device with a packaged electronic subassembly and method for fabricating the same
CN103800045A (en) * 2014-02-24 2014-05-21 梅奇峰 Medical cardiac tamponade object
CN104706444A (en) * 2015-03-03 2015-06-17 上海形状记忆合金材料有限公司 Volume reduction device for left ventricle
CN105476733A (en) * 2016-01-27 2016-04-13 张刚成 Heart volume reduction device

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109009589A (en) * 2018-08-22 2018-12-18 湖南埃普特医疗器械有限公司 A kind of ventricle capacity-reduction device and its transportation system
CN112294494A (en) * 2020-08-18 2021-02-02 上海竑宇医疗科技有限公司 Ring retractor and mounting method thereof
WO2022037183A1 (en) * 2020-08-18 2022-02-24 上海竑宇医疗科技有限公司 Annular constriction device and installation method therefor
CN118105114A (en) * 2024-01-29 2024-05-31 中国人民解放军空军军医大学 A ventricular assist device that can be used for ventricular aneurysm

Similar Documents

Publication Publication Date Title
ES2410795T3 (en) Ventricular partition device
JP4964235B2 (en) Perimeter seal for ventricular compartment device
JP6946266B2 (en) A system for treating acute and chronic heart failure
US7566336B2 (en) Left atrial appendage closure device
JP4519858B2 (en) Ventricular compartment
ES2580209T3 (en) Devices to reduce left atrial pressure
CN102949253B (en) A kind of stent valve and conveyer device thereof
WO2018059178A1 (en) Partial left ventriculectomy device
US9669143B2 (en) Synchronized intraventricular balloon assistance device
US20110184282A1 (en) Self-deploying vascular occlusion device
CN205198210U (en) Type left ventricle of weaving subtracts container tool
CN105120823B (en) Circulatory blood flow recovery device
KR20140128399A (en) Hemodynamic assist device
KR101270233B1 (en) Ventricular Partitioning Device
CN106073947A (en) Heart volume reduction system
Jagschies et al. Individualized biventricular epicardial augmentation technology in a drug-induced porcine failing heart model
CN106344081B (en) A kind of left ventricle volume reduction mechanism
CN109310439A (en) Non-implantable device for temporarily occluding a blood vessel and method of use thereof
CN209474728U (en) One kind taking bolt bracket and takes pin device
CN206151633U (en) Heart subtracts appearance system
Karavelioğlu et al. Dunbar syndrome as an unusual cause of exercise-induced retrosternal pain
CN208591173U (en) An arterial covered stent
Otasevic et al. First-in-man implantation of left ventricular partitioning device in a patient with chronic heart failure: twelve-month follow-up
Wall et al. Extracorporeal membrane oxygenation: an unusual cause of acute limb compartment syndrome
KR101890645B1 (en) Cardiovascular device

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right
TA01 Transfer of patent application right

Effective date of registration: 20171026

Address after: 301 room 4, building 188, Jialing River Road, Suzhou hi tech Zone, Suzhou, Jiangsu, 215009

Applicant after: Suzhou Lainuo Medical Devices Co.

Address before: 215000 room 4, building 188, Jialing River Road, Gaoxin District, Suzhou, Jiangsu, 301

Applicant before: Guan Lijuan

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20161109