CN106053455A - Thread chip and processing technique and processing device thereof - Google Patents
Thread chip and processing technique and processing device thereof Download PDFInfo
- Publication number
- CN106053455A CN106053455A CN201610373088.0A CN201610373088A CN106053455A CN 106053455 A CN106053455 A CN 106053455A CN 201610373088 A CN201610373088 A CN 201610373088A CN 106053455 A CN106053455 A CN 106053455A
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- Prior art keywords
- substrate
- runner
- runners
- wire drain
- nozzle
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- 238000000034 method Methods 0.000 title claims abstract description 13
- 239000000758 substrate Substances 0.000 claims abstract description 86
- 239000000835 fiber Substances 0.000 claims abstract description 26
- 229920000742 Cotton Polymers 0.000 claims abstract description 24
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 17
- 230000002209 hydrophobic effect Effects 0.000 claims description 17
- 229920002678 cellulose Polymers 0.000 claims description 14
- 239000001913 cellulose Substances 0.000 claims description 14
- 239000011248 coating agent Substances 0.000 claims description 13
- 238000000576 coating method Methods 0.000 claims description 13
- 230000007246 mechanism Effects 0.000 claims description 11
- 230000001360 synchronised effect Effects 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 abstract description 13
- 230000008901 benefit Effects 0.000 abstract description 2
- 230000036632 reaction speed Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 238000000018 DNA microarray Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
- B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Plasma & Fusion (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Abstract
The invention relates to a thread chip and a processing technique and processing device thereof. The thread chip comprises: a substrate provided with a linear liquid-guide passage; according to the thread chip and the processing technique and processing device thereof, the direction of the linear liquid-guide passage may be changed at random through cotton threads or strip fibers and the like, a reagent flow path may be adjusted at random as required to control reaction speed of a reagent, and a reaction sequence of the reagent may be controlled when the liquid-guide passage is multi-linear shaped; the thread chip also has the advantages of good processing convenience and low cost.
Description
Technical field
The present invention relates to a kind of biochip field, be specifically related to a kind of core sheet and processing technique, processing unit (plant).
Background technology
Traditional biochip, reagent carries by the way of fluid channel, and the processing technology of fluid channel is sufficiently complex,
Use the means such as laser ablation, soft lithographic or digital control processing, cause chip cost to remain high.
In order to solve above-mentioned technical problem, improve the yield of chip, reduce the cost of manufacture of chip, need design a kind of new
The core sheet of type.
Summary of the invention
It is an object of the invention to provide a kind of core sheet, to solve complex manufacturing technology and the yield of traditional wire chip runner
Low technical problem.
In order to solve above-mentioned technical problem, the invention provides a kind of core sheet, including: substrate, this substrate is provided with line
Shape drain runner.
Further, described wire drain runner includes at least two runners, and is suitable to intersect or level laying；Lay if intersecting
Time, corresponding reagent solution is suitable to be intersected by two runners with mixing respectively；Or the outer layer of at least a part of which one runner is suitable for use with dredging
Aqueous coating wraps up；If level is laid, between two runners, leave gap, or when two runners are close to, at least one runner
Outer layer use hydrophobic coating wrap up.
Further, described substrate is suitable for use with sheet form base or cylindrical substrate；If substrate uses cylindrical substrate, then wire is led
Liquid stream road is that multi-turn coils the face of cylinder in cylindrical substrate.
Further, described runner is suitable for use with cotton thread or fibre strip.
Another aspect, in order to solve the technical problem of the processing of described core sheet, present invention also offers a kind of core sheet
Processing technique and processing unit (plant).
Described processing technique, will be layed in the surface of substrate by wire drain runner.
Further, described wire drain runner includes at least two runners, and is suitable to intersect or level laying, lays if intersecting
Time, corresponding reagent solution is suitable to be intersected by two runners with mixing respectively；Or the outer layer of at least a part of which one runner is suitable for use with dredging
Aqueous coating wraps up；If level is laid, between two runners, leave gap, or when two runners are close to, at least one runner
Outer layer use hydrophobic coating wrap up.
Further, described substrate is suitable for use with sheet form base or cylindrical substrate；If substrate uses cylindrical substrate, then wire is led
Liquid stream road is that multi-turn coils the face of cylinder in cylindrical substrate；And described runner is suitable for use with cotton thread or fibre strip；According to
Cotton thread, then the surface-coated of substrate has glue-line；According to fibre strip, then the surface-coated of substrate has hydrophobic layer；If wire is led
Liquid stream road includes the runner being made up of cotton thread and the runner being made up of fibre strip, then the surface-coated of substrate has hydrophobic glue-line；
And after cellulose solution is ejected into the surface of substrate, carrying out is heating and curing makes cellulose solution be solidified into fibre strip.
The third aspect, the invention provides the processing unit (plant) of a kind of core sheet.
Described processing unit (plant) includes: for laying the nozzle of wire drain runner, and be provided with substrate clamping below this nozzle
Position；Described nozzle is suitable to lay wire drain runner on the surface of substrate.
Further, described nozzle includes cotton thread nozzle and/or cellulose solution nozzle, and is driven by multi-axes synchronous mechanism
Nozzle multiaxis moves, and the most described multi-axes synchronous mechanism is suitable to be adjusted the layout path of wire drain runner by control module.
Further, described substrate uses to be provided with at sheet form base or cylindrical substrate, and substrate clamping position and is suitable to cellulose
Solution carries out being heated and cured into the heater of fibre strip；And
If substrate uses cylindrical substrate, and when nozzle lays wire drain runner, cylindrical substrate is rotated by rotating shaft mechanism,
And nozzle and cylindrical substrate relative motion, so that wire drain runner dish is that multi-turn coils the face of cylinder in cylindrical substrate.
The invention has the beneficial effects as follows, the core sheet of the present invention and processing technique, processing unit (plant), by cotton thread or bar
Shape fiber etc. can arbitrarily change the direction of wire drain runner, can the most arbitrarily regulate the road that reagent solution flows through
Footpath, and then control the response speed of reagent, and when many wire drain runner, the reaction sequence of reagent can be controlled；And this
Core sheet also has easy to process, the advantage of low cost.
Accompanying drawing explanation
The present invention is further described with embodiment below in conjunction with the accompanying drawings.
Fig. 1 is the structural representation of the core sheet of the present invention；
Fig. 2 be the present invention core sheet in two cotton threads structural representation arranged in a crossed manner；
Fig. 3 is along the sectional view of line A-A according to the cotton thread shown in Fig. 2；
Fig. 4 is the structural representation of wire drain runner coiling cylindrical substrate；
Fig. 5 is the structural representation that cotton thread be arranged in parallel with fibre strip；
Fig. 6 is adapted for processing the structural representation of the processing unit (plant) of sheet form base；
Fig. 7 is adapted for processing the structural representation of the processing unit (plant) of cylindrical substrate.
In figure: substrate 1, wire drain runner 2, cotton thread 201, hydrophobic coating 202, fibre strip 203, nozzle 3, substrate
Clamping position 4, multi-axes synchronous mechanism 5, heater 6, rotating shaft mechanism 7.
Detailed description of the invention
In conjunction with the accompanying drawings, the present invention is further detailed explanation.These accompanying drawings are the schematic diagram of simplification, only with
The basic structure of the illustration explanation present invention, therefore it only shows the composition relevant with the present invention.
Embodiment 1
As it is shown in figure 1, a kind of core sheet of the present invention, including: substrate 1, this substrate 1 is provided with wire drain runner 2.
Optionally, described core sheet also includes cover plate；Further, described substrate and cover plate are positioned at described wire drain runner
Two sides, three encapsulation form.
As shown in Figures 2 and 3, as core sheet one preferred embodiment, described wire drain runner include to
Few two runners, and be suitable to intersect or level laying；If intersection is laid, corresponding reagent solution is suitable to be intersected by two runners respectively
To mix (reaction)；Or the outer layer of at least a part of which one runner is suitable for use with hydrophobic coating 202 and wraps up, to realize intersecting also
Non-intersect, i.e. reagent solution does not carry out cross-mixing；If during as it is shown in figure 5, level is laid, leaving gap between two runners, or
When two runners are close to (such as two cotton threads are pooled capital), the outer layer of at least one runner uses hydrophobic coating to wrap up.
As another preferred embodiment of core sheet, described substrate is such as but not limited to using sheet form base, post
Shape substrate；Wherein
As shown in Figure 4, if substrate uses cylindrical substrate, then wire drain runner is that multi-turn coils the face of cylinder in cylindrical substrate.
Concrete, described runner has certain absorptive material such as but not limited to employing cotton thread, fibre strip etc..
Wherein, described fibre strip is suitable to be formed by cellulose solution heating cure (transpiring moisture), described cellulose
Solution is dissolved by corresponding solution after can being pulverized by fibrous material, and by the fibre strip to form solidification of heating.
By the material difference between cotton thread 201 and fibre strip 203, the transmission speed of reagent solution can be controlled.
The operation principle of the core sheet of the present invention: can arbitrarily be changed the shape of runner by wire drain runner 2, with full
The needs of some special occasions of foot, or conversion zone can also be provided with on wire drain runner 2, this conversion zone is provided with test examination
Agent, when reagent solution is after wire drain runner enters conversion zone, reacts with test agent, it is thus achieved that respective reaction is tied
Really, the color of such as conversion zone changes；And can also be provided with multistage conversion zone, even reagent solution first pass through A reaction
Duan Hou, after reacting with the test agent of A conversion zone, through B conversion zone and anti-with the test agent generation of B conversion zone
Should ..., to complete multiple different test agent association response test；In can also using wire drain runner, a plurality of runner will
The mode of corresponding test agent solution cross reaction obtains test data.
Corresponding runner in described wire drain runner can be respectively adopted cotton thread 201 or fibre strip 203 is constituted, and paving
The flow passage route being located at substrate can use intersection or parallel various ways, such as paving mode during multiple flow passages, the most no longer
The most exhaustive, those skilled in the art can derive the multiple laying in substrate of the wire drain runner by the present embodiment mode
Mode.
Embodiment 2
On the basis of embodiment 1, present invention also offers the processing technique of a kind of core sheet, wire drain runner is layed in base
The surface at the end.
Described wire drain runner includes at least two runners, and is suitable to intersect or level laying；If intersection is laid, accordingly
Reagent solution is suitable to be intersected by two runners with mixing respectively；Or the outer layer of at least a part of which one runner is suitable for use with hydrophobic coating
Wrap up；If level is laid, leave gap between two runners, or when two runners are close to, the outer layer of at least one runner is adopted
Wrap up with hydrophobic coating.
Preferably, described substrate is suitable for use with sheet form base or cylindrical substrate, if substrate uses cylindrical substrate, then wire is led
Liquid stream road is that multi-turn coils the face of cylinder in cylindrical substrate；And described runner is suitable for use with cotton thread or fibre strip；According to
Cotton thread, then the surface-coated of substrate has glue-line；According to fibre strip, then the surface-coated of substrate has hydrophobic layer；If wire is led
Liquid stream road includes the runner being made up of cotton thread and the runner being made up of fibre strip, then the surface-coated of substrate has hydrophobic glue-line；
And after cellulose solution is ejected into the surface of substrate, carrying out is heating and curing makes cellulose solution be solidified into fibre strip.
Embodiment 3
On the basis of embodiment 1 and embodiment 2, present invention also offers the processing unit (plant) of a kind of core sheet, including: it is used for laying
Substrate clamping position 4 it is provided with below the nozzle 3 of wire drain runner 2, and this nozzle 3；Described nozzle is suitable to spread on the surface of substrate
If wire drain runner.
As shown in Figure 6, as this processing unit (plant) one preferred embodiment.
Described nozzle includes cotton thread nozzle and/or cellulose solution nozzle, and drives nozzle many by multi-axes synchronous mechanism 5
Axle moves, and the most described multi-axes synchronous mechanism is suitable to be adjusted the layout path of wire drain runner by control module.
Described substrate uses to be provided with at sheet form base or cylindrical substrate, and substrate clamping position and is suitable to carry out cellulose solution
It is heated and cured into the heater 6 of fibre strip；And if substrate uses cylindrical substrate, and when nozzle lays wire drain runner
Time, cylindrical substrate is rotated by rotating shaft mechanism 7, and nozzle and cylindrical substrate relative motion, so that wire drain runner dish
The face of cylinder in cylindrical substrate is coiled in multi-turn.
With the above-mentioned desirable embodiment according to the present invention for enlightenment, by above-mentioned description, relevant staff is complete
Entirely can carry out various change and amendment in the range of without departing from this invention technological thought.The technology of this invention
The content that property scope is not limited in description, it is necessary to determine its technical scope according to right.
Claims (10)
1. a core sheet, it is characterised in that including: substrate, this substrate is provided with wire drain runner.
Core sheet the most according to claim 1, it is characterised in that described wire drain runner includes at least two runners, and
Be suitable to intersect or level laying；
If intersection is laid, corresponding reagent solution is suitable to be intersected by two runners with mixing respectively；Or at least a part of which one runner
Outer layer is suitable for use with hydrophobic coating and wraps up；
If level is laid, between two runners, leave gap, or when two runners are close to, the outer layer of at least one runner uses hydrophobic
Property coating is wrapped up.
Core sheet the most according to claim 1, it is characterised in that described substrate is suitable for use with sheet form base or column base
The end；
If substrate uses cylindrical substrate, then wire drain runner is that multi-turn coils the face of cylinder in cylindrical substrate.
4. according to the core sheet described in Claims 2 or 3, it is characterised in that described runner is suitable for use with cotton thread or fibre strip.
5. the processing technique of a core sheet, it is characterised in that wire drain runner is layed in the surface of substrate.
Processing technique the most according to claim 5, it is characterised in that
Described wire drain runner includes at least two runners, and is suitable to intersect or level laying；
If intersection is laid, corresponding reagent solution is suitable to be intersected by two runners with mixing respectively；Or at least a part of which one runner
Outer layer is suitable for use with hydrophobic coating and wraps up；
If level is laid, between two runners, leave gap, or when two runners are close to, the outer layer of at least one runner uses hydrophobic
Property coating is wrapped up.
Processing technique the most according to claim 6, it is characterised in that described substrate is suitable for use with sheet form base or column base
The end；
If substrate uses cylindrical substrate, then wire drain runner is that multi-turn coils the face of cylinder in cylindrical substrate；And
Described runner is suitable for use with cotton thread or fibre strip；
According to cotton thread, then the surface-coated of substrate has glue-line；
According to fibre strip, then the surface-coated of substrate has hydrophobic layer；
If wire drain runner includes the runner being made up of cotton thread and the runner being made up of fibre strip, the then surface-coated of substrate
There is hydrophobic glue-line；And
After cellulose solution is ejected into the surface of substrate, carrying out is heating and curing makes cellulose solution be solidified into fibre strip.
8. the processing unit (plant) of a core sheet, it is characterised in that including: for laying the nozzle of wire drain runner, and this spray
Substrate clamping position it is provided with below mouth；
Described nozzle is suitable to lay wire drain runner on the surface of substrate.
Processing unit (plant) the most according to claim 8, it is characterised in that
Described nozzle includes cotton thread nozzle and/or cellulose solution nozzle, and drives nozzle multiaxis to move by multi-axes synchronous mechanism
Dynamic, i.e.
Described multi-axes synchronous mechanism is suitable to be adjusted the layout path of wire drain runner by control module.
Processing unit (plant) the most according to claim 9, it is characterised in that
Described substrate uses to be provided with at sheet form base or cylindrical substrate, and substrate clamping position and is suitable to heat cellulose solution
It is solidified into the heater of fibre strip；And
If substrate uses cylindrical substrate, and when nozzle lays wire drain runner, cylindrical substrate is rotated by rotating shaft mechanism,
And nozzle and cylindrical substrate relative motion, so that wire drain runner dish is that multi-turn coils the face of cylinder in cylindrical substrate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610373088.0A CN106053455A (en) | 2016-05-30 | 2016-05-30 | Thread chip and processing technique and processing device thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610373088.0A CN106053455A (en) | 2016-05-30 | 2016-05-30 | Thread chip and processing technique and processing device thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106053455A true CN106053455A (en) | 2016-10-26 |
Family
ID=57173071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610373088.0A Pending CN106053455A (en) | 2016-05-30 | 2016-05-30 | Thread chip and processing technique and processing device thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106053455A (en) |
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|---|---|---|---|---|
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| US20080124663A1 (en) * | 2000-05-25 | 2008-05-29 | President And Fellows Of Harvard College | Microfluidic systems including three-dimensionally arrayed channel networks |
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| US20130299352A1 (en) * | 2012-05-10 | 2013-11-14 | National Sun Yat-Sen University | Thread-based microfluidic guiding system |
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| CN104998702A (en) * | 2015-07-03 | 2015-10-28 | 南京理工大学 | Preparation method of PDMS microfluidic chip based on liquid composite molding method |
| CN105036052A (en) * | 2015-06-04 | 2015-11-11 | 清华大学 | Micro needle tip with orientation structure and method thereof for continuously conveying liquid |
-
2016
- 2016-05-30 CN CN201610373088.0A patent/CN106053455A/en active Pending
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|---|---|---|---|---|
| US20080124663A1 (en) * | 2000-05-25 | 2008-05-29 | President And Fellows Of Harvard College | Microfluidic systems including three-dimensionally arrayed channel networks |
| CN2483395Y (en) * | 2001-06-20 | 2002-03-27 | 郭占军 | Capillary bio-chip device |
| CN1687766A (en) * | 2005-04-21 | 2005-10-26 | 复旦大学 | Fibrous electrophoresis chip and preparation method |
| CN101274469A (en) * | 2007-12-29 | 2008-10-01 | 重庆大学 | Construction method of micro-dot array in micro-channel |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161026 |
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