CN106038960A - 一种骨伤科用于消肿止痛的中药喷剂及其制备方法 - Google Patents
一种骨伤科用于消肿止痛的中药喷剂及其制备方法 Download PDFInfo
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Abstract
本发明提供一种骨伤科用于消肿止痛的中药喷剂及其制备方法，属于中药制剂技术领域，该骨伤科用于消肿止痛的中药喷剂选配比为：三七15g、白芷20g、羌活15g、独活15g、没药9g、金银花20g、连翘20g、穿山甲20g、五加皮20g、杜仲20g、牛膝20g、栀子15g、川芎20g、贝母15g、天花粉20g、透骨草20g、延胡索20g、红花20g、赤芍20g和酒精1L。本发明药物治疗骨伤科肿痛疗效显著，无毒副作用，药效稳定，制取工艺简单，生产成本低，适用于基层医疗单位引进、推广，能为广大的骨伤患者所接受。
Description
技术领域
本发明属于中药制剂技术领域，尤其涉及一种骨伤科用于消肿止痛的中药喷剂及其制备方法。
背景技术
肿胀、疼痛是由实际的或潜在的组织损伤所引起的不愉快感觉，也是一种预警机制，防止机体遭受压迫或进一步损伤，是当今困扰人类健康的严重问题之一。现在医学研究表明，肿胀是由于毛细血管破裂、出血以及血管壁的通透性增加， 血管内液外渗到组织间隙所致；而疼痛又是由于创伤性血肿或炎性反应物刺激局部末梢神经引起。在治疗上应当活血祛瘀、理气止痛。目前，临床上对多种急慢性疼痛多采取西药治疗为主，其疗效已得到肯定，但长期使用会引起成瘾性等不良反应。因此，寻找副作用和依赖性小的消肿止痛中药已成为新趋势。中医学治疗痛证已有几千年的历史，在《黄帝内经》 中，就已对痛证的病因、病机、病位、证候、预后等方面进行了系统的论述。中医理论认为“痛则不通，通则不痛”，据此为主治疗各种疼痛的中药及中药复方在中医临床中应用广泛。
目前，现有治疗骨伤造成的肿胀、疼痛的主要方法是：1、膏药，使用膏药会使皮肤毛孔得不到呼吸出现湿疹情况，造成皮肤瘙痒等症状，而且容易弄脏衣服，药味刺鼻，给患者带来不便。2、内服治疗，主要是消炎、镇痛，药效不能直接到达患处，消炎药主要成分是抗生素，会给人体肝脏、肾脏带巨大损害， 对人体其他器官也有伤害。3、其他外用喷剂，现有外用喷剂主要是合成药剂制成的， 有些患者会导致皮肤过敏现象，而且工艺复杂成本也比较高。
但是，现有的技术存在着临床治疗疗效不佳，存在一定副作用，制造工艺复杂，生产成本较高的问题。
因此，发明一种骨伤科用于消肿止痛的中药喷剂及其制备方法显得非常必要。
发明内容
为了解决上述技术问题，本发明提供一种农作物秸秆生物发酵法制取纤维工艺，以解决现有的技术存在着临床治疗疗效不佳，存在一定副作用，制造工艺复杂，生产成本较高的问题。一种骨伤科用于消肿止痛的中药喷剂包括以下重量份数的原料药：三七15～20g、白芷20～25g、羌活15～20g、独活15～20g、没药9～15g、金银花20～25g、连翘20～25g、穿山甲20～25g、五加皮20～25g、杜仲20～25g、牛膝20～25g、栀子15～20g、川芎20～25g、贝母15～20g、天花粉20～25g、透骨草20～25g、延胡索20～25g、红花20～25g、赤芍20～25g和酒精0.5～1L。
优选地，所述的骨伤科用于消肿止痛的中药喷剂包括以下重量份数的原料药：三七10～15g、白芷15～20g、羌活10～15g、独活10～15g、没药6～9g、金银花15～20g、连翘15～20g、穿山甲15～20g、五加皮15～20g、杜仲15～20g、牛膝15～20g、栀子10～15g、川芎15～20g、贝母10～15g、天花粉15～20g、透骨草15～20g、延胡索15～20g、红花15～20g、赤芍15～20g和酒精1～1.5L。
优选地，一种骨伤科用于消肿止痛的中药喷剂包括以下重量份数的原料药优选配比为：三七15g、白芷20g、羌活15g、独活15g、没药9g、金银花20g、连翘20g、穿山甲20g、五加皮20g、杜仲20g、牛膝20g、栀子15g、川芎20g、贝母15g、天花粉20g、透骨草20g、延胡索20g、红花20g、赤芍20g和酒精1L。
优选地，一种骨伤科用于消肿止痛的中药喷剂包括以下重量份数的原料药优选配比为：三七20g、白芷25g、羌活20g、独活20g、没药15g、金银花25g、连翘25g、穿山甲25g、五加皮25g、杜仲25g、牛膝25g、栀子20g、川芎25g、贝母20g、天花粉25g、透骨草25g、延胡索25g、红花25g、赤芍25g和酒精1.5L。
优选地，一种骨伤科用于消肿止痛的中药喷剂包括以下重量份数的原料药优选配比为：三七10g、白芷15g、羌活10g、独活10g、没药6g、金银花15g、连翘15g、穿山甲15g、五加皮15g、杜仲15g、牛膝15g、栀子10g、川芎15g、贝母10g、天花粉15g、透骨草15g、延胡索15g、红花15g、赤芍15g和酒精0.5L。
优选地，所述的骨伤科用于消肿止痛的中药喷剂制备方法制备工艺包括以下步骤：
步骤一：按比例量取各原料药；
步骤二：将原料药过100目筛制成混合均匀的药粉；
步骤三：混合药粉加入体积浓度为80%酒精进行浸泡；
步骤四：将步骤三中的酒精混合液过滤，滤除滤渣；
步骤五：将步骤四中的滤液装入喷剂瓶，储存温度为10℃至15℃。
优选地，在步骤三中，所述的药粉浸泡环境稳定为15℃至25℃，有利于改善浸泡效果，保障药物疗效。
优选地，在步骤三中，所述的药粉浸泡时间为15天至25天。
优选地，所述的骨伤科用于消肿止痛的中药喷剂喷涂于肿胀疼痛处，每日2至3次；8天为一个疗程，两个疗程间隔2日。
本发明中药原料药的药理作用如下：
透骨草：有活血化瘀、利尿解毒、通经透骨之功效。
杜仲：补肝肾，强筋骨，安胎。治腰脊酸疼，足膝痿弱，小便余沥，阴下湿痒，胎漏欲堕，胎动不安，高血压。
川芎：行气药；祛风药；活血药；活血祛瘀；行气开郁；祛风止痛
制没药：主治胸腹瘀痛、痛经、经闭、癥瘕、跌打损伤、痈肿疮疡、肠痈、目赤肿痛。有活血止痛、消肿生肌等功效。
红花：活血通经，去瘀止痛。活血通经药。
三七：具有散瘀止血，消肿定痛之功效。主治咯血，吐血，衄血，便血，崩漏，外伤出血，胸腹刺痛，跌仆肿痛。
牛膝：活血祛瘀药。性味；苦；酸；性平。
与现有技术相比，本发明所述中药喷剂以上述二十余种中药材为原料，发挥协同作用，制得的中药喷剂具有活血散瘀，消肿止痛，舒筋活络的功效，可用于跌打损伤、淤血肿痛等各种软组织损伤及风湿病痛，制取工艺简单，成本低，治疗效果较好。
附图说明
图1是骨伤科用于消肿止痛的中药喷剂制备方法工艺流程图。
具体实施方式
下面结合实施例对本发明做进一步说明。
实施例1
一种骨伤科用于消肿止痛的中药喷剂包括以下重量份数的原料药优选配比为：三七15g、白芷20g、羌活15g、独活15g、没药9g、金银花20g、连翘20g、穿山甲20g、五加皮20g、杜仲20g、牛膝20g、栀子15g、川芎20g、贝母15g、天花粉20g、透骨草20g、延胡索20g、红花20g、赤芍20g和酒精1L。
实施例2
一种骨伤科用于消肿止痛的中药喷剂包括以下重量份数的原料药优选配比为：三七20g、白芷25g、羌活20g、独活20g、没药15g、金银花25g、连翘25g、穿山甲25g、五加皮25g、杜仲25g、牛膝25g、栀子20g、川芎25g、贝母20g、天花粉25g、透骨草25g、延胡索25g、红花25g、赤芍25g和酒精1.5L。
实施例3
一种骨伤科用于消肿止痛的中药喷剂包括以下重量份数的原料药优选配比为：三七10g、白芷15g、羌活10g、独活10g、没药6g、金银花15g、连翘15g、穿山甲15g、五加皮15g、杜仲15g、牛膝15g、栀子10g、川芎15g、贝母10g、天花粉15g、透骨草15g、延胡索15g、红花15g、赤芍15g和酒精0.5L。
本发明的中药喷剂及其制备方法制备工艺包括以下步骤：
S101：按比例量取各原料药；
S102：将原料药过100目筛制成混合均匀的药粉；
S103：混合药粉加入体积浓度为80%酒精进行浸泡；
S104：将S103中的酒精混合液过滤，滤除滤渣；
S105：将S104中的滤液装入喷剂瓶，储存温度为10℃至15℃。
优选地，在S103中，所述的药粉浸泡环境稳定为15℃至25℃，有利于改善浸泡效果，保障药物疗效。
优选地，在S103中，所述的药粉浸泡时间为15天至25天。
优选地，所述的骨伤科用于消肿止痛的中药喷剂喷涂于肿胀疼痛处，每日2至3次；8天为一个疗程，两个疗程间隔2日。
与现有技术相比，本发明所述中药喷剂以上述二十余种中药材为原料，发挥协同作用，制得的中药喷剂具有活血散瘀，消肿止痛，舒筋活络的功效，可用于跌打损伤、淤血肿痛等各种软组织损伤及风湿病痛，制取工艺简单，成本低， 治疗效果较好。
临床疗效验证：
本发明临床观察的结果如下：
疗效标准：
治愈：临床症状完全消失，活动能力恢复正常；有效：症状有所改善，活动范围和强度达到65%，仍遗有不适或隐痛；无效：症状无改善或病情加重。
药物疗效观察情况：本发明药物治疗 100人， 痊愈者 85人， 有效者 10人， 无效者 5人， 有效率 95％。
利用本发明所述的技术方案，或本领域的技术人员在本发明技术方案的启发下，设计出类似的技术方案，而达到上述技术效果的，均是落入本发明的保护范围。
Claims (9)
1.一种骨伤科用于消肿止痛的中药喷剂，其特征在于，该骨伤科用于消肿止痛的中药喷剂包括以下重量份数的原料药：三七15～20g、白芷20～25g、羌活15～20g、独活15～20g、没药9～15g、金银花20～25g、连翘20～25g、穿山甲20～25g、五加皮20～25g、杜仲20～25g、牛膝20～25g、栀子15～20g、川芎20～25g、贝母15～20g、天花粉20～25g、透骨草20～25g、延胡索20～25g、红花20～25g、赤芍20～25g和酒精0.5～1L。
2.如权利要求1所述的骨伤科用于消肿止痛的中药喷剂，其特征在于，包括以下重量份数的原料药：三七10～15g、白芷15～20g、羌活10～15g、独活10～15g、没药6～9g、金银花15～20g、连翘15～20g、穿山甲15～20g、五加皮15～20g、杜仲15～20g、牛膝15～20g、栀子10～15g、川芎15～20g、贝母10～15g、天花粉15～20g、透骨草15～20g、延胡索15～20g、红花15～20g、赤芍15～20g和酒精1～1.5L。
3.如权利要求1所述的骨伤科用于消肿止痛的中药喷剂，其特征在于，包括以下重量份数的原料药优选配比为：三七15g、白芷20g、羌活15g、独活15g、没药9g、金银花20g、连翘20g、穿山甲20g、五加皮20g、杜仲20g、牛膝20g、栀子15g、川芎20g、贝母15g、天花粉20g、透骨草20g、延胡索20g、红花20g、赤芍20g和酒精1L。
4.如权利要求1所述的骨伤科用于消肿止痛的中药喷剂，其特征在于，包括以下重量份数的原料药优选配比为：三七20g、白芷25g、羌活20g、独活20g、没药15g、金银花25g、连翘25g、穿山甲25g、五加皮25g、杜仲25g、牛膝25g、栀子20g、川芎25g、贝母20g、天花粉25g、透骨草25g、延胡索25g、红花25g、赤芍25g和酒精1.5L。
5.如权利要求1所述的骨伤科用于消肿止痛的中药喷剂，其特征在于，包括以下重量份数的原料药优选配比为：三七10g、白芷15g、羌活10g、独活10g、没药6g、金银花15g、连翘15g、穿山甲15g、五加皮15g、杜仲15g、牛膝15g、栀子10g、川芎15g、贝母10g、天花粉15g、透骨草15g、延胡索15g、红花15g、赤芍15g和酒精0.5L。
6.如权利要求1所述的骨伤科用于消肿止痛的中药喷剂，其特征在于，所述的骨伤科用于消肿止痛的中药喷剂及其制备方法制备工艺包括以下步骤：
步骤一：按比例量取各原料药；
步骤二：将原料药过100目筛制成混合均匀的药粉；
步骤三：混合药粉加入体积浓度为80%酒精进行浸泡；
步骤四：将步骤三中的酒精混合液过滤，滤除滤渣；
步骤五：将步骤四中的滤液装入喷剂瓶，储存温度为10℃至15℃。
7.如权利要求6所述的骨伤科用于消肿止痛的中药喷剂制备方法，其特征在于，在步骤三中，所述的药粉浸泡环境稳定为15℃至25℃。
8.如权利要求6所述的骨伤科用于消肿止痛的中药喷剂制备方法，其特征在于，在步骤三中，所述的药粉浸泡时间为15天至25天。
9.如权利要求1所述的骨伤科用于消肿止痛的中药喷剂，其特征在于，所述的骨伤科用于消肿止痛的中药喷剂喷涂于肿胀疼痛处，每日2至3次；8天为一个疗程，两个疗程间隔2日。
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