CN106036133A - Feed additive capable of preventing and treating chronic aleutian disease of minks and preparation method of feed additive - Google Patents

Abstract

The invention discloses a feed additive capable of preventing and treating a chronic aleutian disease of minks and a preparation method of the feed additive. The feed additive is prepared from the following components of enteromorpha, seeds of coral peatree, black sesame seeds, kelp, clamworm powder, fish scales, olive oil, herb of sibirica walking fern, radix rubiae, roots of snow of June, kochia scoparia seedlings, largehead atractylodes rhizomes, corn stigma, fennel fruits, radix linderae, bauhinia variegate roots, bark, leaves and flowers, pummelo seeds, russula virescens, roots or stem of smoothfruit ventilago, roots of silverweed cinquefoil, radix curcumae, ginseng, radix polygoni multiflori and licorice roots. The feed additive disclosed by the invention does not contain antibiotics, is non-toxic and harmless to the minks, and is convenient to use; medicines can exert effects quickly, the feed additive has a good treatment effect on the minks suffering from the chronic aleutian disease, the immunity of the minks is strengthened, and increase of economic benefits of breeding households is facilitated.

Description

Feed additive of the preventing and treating chronic AD of mink and preparation method thereof

Technical field

The present invention relates to a kind of feed additive, be specifically related to a kind of feedstuff preventing and treating the chronic AD of mink and add Agent, the invention still further relates to the preparation method of this feed additive.

Background technology

Standard mink skin is the fur coat of a kind of preciousness, and kind color is varied, expensive, has the laudatory title of " king of fur coat ". In terms of the quality and value of standard mink skin, its utilization rate is also above the big capillary skin such as Vulpes, raccoon fur, and especially domestic market potentiality are very Greatly.Standard mink skin is the shortest with its lint, bright luxurious and famous, is the most former of making clothes, collar, medicated cap, cuff and decorations mouth Material skin, utilizes face relatively wide, and demand is the biggest.And the big capillary skin such as Vulpes, raccoon fur, owing to lint relatively standard mink skin is the longest, not as good as mink Skin is magnificent, and domestic market is not suitable for overcoat processed, and is only suitable for making the ornaments such as collar, cuff, tippet, therefore utilization rate relatively standard mink skin Low.As can be seen here, the development prospect of the little capillary skin animal based on mink is better than the big capillary skin animal such as Vulpes, Nyctereutes procyonoides.

Aleutian disease (aleutian disease ofmink) also known as plasmacytosis (plasmacytosis), Be by aleutian disease virus infect that mink causes increase with lifelong toxemia, total lymphoid cell proliferation, serum r-globulin number, The chronic viral diseases that glomerulonephritis, arteries inflammation and hepatitis are characterized.AD is that the distinctive a kind of course of disease of mink is entered Opening up extremely slow infectious disease, all have generation in each foster ermine country of senior sister apprentice, the mink of all strains all can infect, and has A Liushen The mink of genotype even has 1/3 to die from this disease, and Aleutian disease can make female nonpregnant rate of ermine and young ermine mortality rate significantly increase, The mating ability of public ermine declines, moreover it is possible to impact is grown and made fur quality low, causes economic loss, is universally acknowledged foster ermine One of three big epidemic diseases.

AD acute case is very brief due to the course of disease, often can't see manifest symptom and sudden death, natural infection Sick ermine, how in chronic progressive external process, minority shows the acute course of disease, just accuses death, under field conditions (factors), directly connect after 2-3 days Average out to 60-90 days incubation period of sense of touch dye, raises the mink in cage, and incubation period is the longest up to 7-8 month as long as；Non-warp Average out to 21-30 days incubation period of intestinal infection；The incubation period of experimental infection is about 6 days.The course of disease of chronic process be the several months or Several years, result nearly all comes to an end with death.

The generation of China's Aleutian disease at present presents chronic process more, acute process seldom occurs；Therefore, this disease institute The loss caused does not causes the abundant attention of raiser always.The loss that this disease causes is many:

1. causing mink death Aleutian disease is a kind of chronic disease, causes mink histoorgan chronic disease, the course of disease Can continued over many weeks or several months.This disease may result in mink Abwehrkraft des Koepers and declines, and causes mink big when the autumn and winter hand over season, abrupt change of climate Amount death.

2. affecting this disease and can cause female ermine non-estrus, nonpregnant, miscarriage, dead rotten tire, weak tire mink reproductive performance；Public ermine Breeding capacity declines, and motility of sperm reduces, and causes serious, invisible economic loss to cultivation unit.

3. the mink clinical signs in chronic and recessive process that affects on hide grade is progressive emaciation, and mink is raw Long hypoevolutism, by hair restless with anxiety, tarnish, exhaustion of highly becoming thin, subcutaneous fat is the most depleted, and dermatotome is little, inadequate grade, Essentially wait crust.

AD does not the most generally acknowledge effective vaccine at present, does not has the specific treatment of this disease yet, uses immunosuppressant Treated with cyclophosphamide pulse, can control the appearance of AD pathological changes within a certain period of time, but can not thoroughly cure, and AD degree Also had certain resistance to it, therapeutic effect is worse.Therefore, the most reliable method is to be quarantined by repeatedly specificity, Eliminate sick ermine, purify ermine field, cause the biggest economic loss to plant.

Summary of the invention

It is an object of the invention to provide a kind of feed additive preventing and treating chronic Aleutian disease and preparation method thereof, this The feed additive of invention is pure Chinese medicinal preparation, does not contains chemical drugs or antibiotic, nontoxic to mink, and user Just, medicine can play a role rapidly, good to the therapeutic effect of the mink suffering from AD, strengthens the immunity of mink, favorably In the economic benefit improving raiser.

To achieve these goals, present invention provide the technical scheme that

A kind of feed additive preventing and treating the chronic AD of mink, is made up of each component of following parts by weight: Entermorpha 20-40 part, Semen adenantherae pavoninae 20-30 part, Semen Sesami Nigrum 10-20 part, Thallus Laminariae (Thallus Eckloniae) 20-30 part, clam worm powder 5-15 part, fish scale 8-16 part, Fructus Canarii albi Oil 6-8 part, Herba Camptosori Sibirici 20-30 part, Radix Rubiae 10-18 part, Radix Serissae 8-18 part, Caulis et Folium Kochiae 4-10 part, Rhizoma Atractylodis Macrocephalae 12-18 part, Semen Maydis Must 20-30 part, Fructus Foeniculi 10-20 part, Radix Linderae 15-25 part, Bauhinia purpurea 5-15 part, Semen Citri grandis 5-10 part, Russula vivesscens (Schaeff.) Franch. 4-8 part, blood wind Rattan 6-10 part, Radix potentillae anserinae 6-10 part, Radix Curcumae 10-20 part, Radix Ginseng 10-20 part, Radix Polygoni Multiflori 6-12 part, Radix Glycyrrhizae 6-12 part.

Further, a kind of feed additive preventing and treating the chronic AD of mink, by each component of following parts by weight Make: Entermorpha 20 parts, Semen adenantherae pavoninae 20 parts, Semen Sesami Nigrum 10 parts, 20 parts of Thallus Laminariae (Thallus Eckloniae), clam worm powder 5 parts, 8 parts of fish scale, 6 parts of olive oil, stirrup Grass 20 parts, 10 parts of Radix Rubiae, Radix Serissae 8 parts, Caulis et Folium Kochiae 4 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Stigma Maydis 20 parts, Fructus Foeniculi 10 parts, the Radix Linderae 15 parts, Bauhinia purpurea 5 parts, Semen Citri grandis 5 parts, Russula vivesscens (Schaeff.) Franch. 4 parts, Radix seu Caulis Verntilaginis Leiocarpae 6 parts, Radix potentillae anserinae 6 parts, Radix Curcumae 10 parts, Radix Ginseng 10 parts, Radix Polygoni Multiflori 6 parts, sweet Grass 6 parts.

Further, a kind of feed additive preventing and treating the chronic AD of mink, by each component of following parts by weight Make: Entermorpha 40 parts, Semen adenantherae pavoninae 30 parts, Semen Sesami Nigrum 20 parts, 30 parts of Thallus Laminariae (Thallus Eckloniae), clam worm powder 15 parts, 16 parts of fish scale, 8 parts of olive oil, horse Pedal grass 30 parts, 18 parts of Radix Rubiae, Radix Serissae 18 parts, Caulis et Folium Kochiae 10 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Stigma Maydis 30 parts, Fructus Foeniculi 20 parts, the Radix Linderae 25 Part, Bauhinia purpurea 15 parts, Semen Citri grandis 10 parts, Russula vivesscens (Schaeff.) Franch. 8 parts, Radix seu Caulis Verntilaginis Leiocarpae 10 parts, Radix potentillae anserinae 10 parts, Radix Curcumae 20 parts, Radix Ginseng 20 parts, Radix Polygoni Multiflori 12 parts, 12 parts of Radix Glycyrrhizae.

Further, a kind of feed additive preventing and treating the chronic AD of mink, by each component of following parts by weight Make: Entermorpha 30 parts, Semen adenantherae pavoninae 25 parts, Semen Sesami Nigrum 15 parts, 25 parts of Thallus Laminariae (Thallus Eckloniae), clam worm powder 10 parts, 12 parts of fish scale, 7 parts of olive oil, horse Pedal grass 25 parts, 14 parts of Radix Rubiae, Radix Serissae 13 parts, Caulis et Folium Kochiae 7 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Stigma Maydis 25 parts, Fructus Foeniculi 15 parts, the Radix Linderae 20 Part, Bauhinia purpurea 10 parts, Semen Citri grandis 8 parts, Russula vivesscens (Schaeff.) Franch. 6 parts, Radix seu Caulis Verntilaginis Leiocarpae 8 parts, Radix potentillae anserinae 8 parts, Radix Curcumae 15 parts, Radix Ginseng 15 parts, Radix Polygoni Multiflori 9 Part, 9 parts of Radix Glycyrrhizae.

It is a further object of the present invention to provide the preparation method of a kind of feed additive preventing and treating the chronic AD of mink, Comprise the following steps:

(1) choose fresh Entermorpha, Thallus Laminariae (Thallus Eckloniae), fish scale, after cleaning up, after carrying out vacuum lyophilization, pulverize, cross 100 Mesh mesh screen, obtains mixed powder A；

(2) after Semen adenantherae pavoninae, the little fire of Semen Sesami Nigrum being fried, pulverize, cross 100 mesh mesh screens, obtain mixed powder B；

(3) by Herba Camptosori Sibirici, Radix Rubiae, Radix Serissae, Caulis et Folium Kochiae, the Rhizoma Atractylodis Macrocephalae, Stigma Maydis, Fructus Foeniculi, the Radix Linderae, Bauhinia purpurea, Semen Citri grandis, green grass or young crops Grinding to 80 mesh after head bacterium, Radix seu Caulis Verntilaginis Leiocarpae, Radix potentillae anserinae, Radix Curcumae, Radix Ginseng, Radix Polygoni Multiflori, Radix Glycyrrhizae mixing, gross weight is designated as 1 part, adds 3 parts of sterilized water, 1 part of ethanol, soak 1h, then be collectively disposed in microwave extracting tank by said medicine and liquid at 50 ± 5 DEG C Row extraction, control microwave frequency is 1000MHz, and microwave power is 100W/L, carries out microwave radiation, then by the work in extractor Making pressure to step up in 5-10min to 0.3MPa, microwave irradiation time amounts to 30min, obtains extract；

(4) after the extract of step (3) being decompressed, filter, reclaim ethanol, collect filtrate, filtrate is spray-dried, in obtaining Medicated powder；

(5) mixed powder A, mixed powder B and the Chinese medicine powder that clam worm powder, olive oil are obtained respectively with step (1), (2), (4) Mix homogeneously, sterilizing, obtain the described feed additive preventing and treating Aleutian disease.

Store method: cryopreservation at-7-2 DEG C.

Using method: after the feed additive of the present invention is heated to room temperature, with normal feedstuff with 1:(10-20) ratio Throw something and feed after mix homogeneously, one day three times.

The raw materials used effect of inventive formulation is as follows:

Entermorpha: being a kind of large-scale chlorella, Entermorpha is not only rich in carbohydrate, protein, crude fibre, aminoacid, fat Acid, vitamin and several mineral materials, and there is heat-clearing and toxic substances removing, anti-inflammation, cholesterol reducing, enhancing human body immunity power, softening the hard mass Eliminating stagnation, swelling diuretic and effect of change disease.According to " with breath occupy diet spectrum " record: Entermorpha " gallbladder that disappears, the scrofula goiter that disappears, let out swollen, change Expectorant, control being not acclimatized "；Coastal spreading so far controls acute and chronic gastroenteritis with ulva class decoction, and Entermorpha is then relieved summer heat removing toxic substances by Guangdong Beverage.Entermorpha, rich in polysaccharide, accounts for Sargassum dry weight more than 50%, has biological activity and blood fat reducing, antitumor, disease-resistant widely The medicinal function such as malicious, antibacterial, regulation immunity, antioxidation, resisting fatigue and blood sugar lowering, can be widely applied to medicine, health food And bread and cheese；Semen adenantherae pavoninae: for the general designation of the plant seeds such as Ormosia hosiei, Semen adenantherae pavoninae and Semen Abri Precatorii.Sweet acid, flat, nontoxic, heat extraction Poison, dispelling malignant blood, relieving distension is full, diuresis, lactogenesis, carbuncle pus and blood, lower distention and fullness in the abdomen, dysuria, edema tinea pedis, and dysphoria with smothery sensation is very thirsty, wine Disease, dysentery, jaundice, perianal abscess hematochezia, galactostasis；Dry bean 21-23% in protein, fat 0.3%, carbohydrate 65%., Containing several mineral materials and aminoacid, especially higher with lysine content；Semen Sesami Nigrum: for the black seeds of Pedaliaceae Semen Sesami.Contain Substantial amounts of fat and protein, possibly together with nutritional labelings such as saccharide, VitAVitE, lecithin, calcium, ferrum, chromium.Sweet in the mouth, Property flat.There is a nourishing the liver and kidney, benefit blood intestine moistening, relieving constipation, the function of lactogenesis, also stomach invigorating, protect the liver, promote the effect of red blood cell growth, Internal melanin, beneficially natural on-off cycles of hair growth can be increased simultaneously；Thallus Laminariae (Thallus Eckloniae): be that a kind of large-scale sea grown in low temperature seawater is raw brown Algae plant, belongs to seaweed plant.Can hypertension and hyperlipemia, raising immunity, inducing diuresis to remove edema, effect of slow down aging.Thallus Laminariae (Thallus Eckloniae) contains Abundant cellulose, it is possible to understand refuse and toxin in intestinal in time, therefore, it can be effectively prevented rectal cancer and constipation Occur；Fish scale: refer to fish appearance protection self, prevent the shell that current lose, be typically fan-shaped.Fish scale contain rich in protein, Fat and multivitamin, also ferrum, zinc, calcium and the trace element of multiple needed by human and colloid.Possibly together with many in fish scale Plant unsaturated fatty acid, cholesterol accumulation in blood vessel wall can be reduced, there are prevention of arterial hardening, hypertension and heart disease etc. Effect；Olive oil: olive oil is by the fresh direct cold pressing of Fructus oleae europaeae fruit, the most heated and chemical treatment, retains Natural nutrient component, rich in abundant monounsaturated fatty acid oleic acid, also vitamin A, vitamin B, vitamin D, Vitamin E, vitamin K and polyphenoils etc..Can defying age, improve digestive system function, easily absorbed, skin bullet can be strengthened Property；Herba Camptosori Sibirici: basis, medicine source is the herb of Aspleniaceae plant walking fern.Light, flat.Blood circulation promoting and blood stasis dispelling, hemostasis, removing toxic substances.Main thrombosis Thromboangiitis obliterans, hemiplegia, metrorrhagia, traumatic hemorrhage, neurodermatitis, ulcer of the lower limb；Radix Rubiae: medicinal part is Rubiaceae The dry root and rhizome of plant Radix Rubiae.Hardship, cold.Return Liver Channel.Removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow.For spitting blood, epistaxis, metrorrhagia, outward Hinder hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling；Radix Serissae: medicinal part is Maguireothamnus speciosus Radix Serissae or Serissa foetida Herb.Toil, cool.Dispel the wind, dampness removing, heat clearing away, removing toxic substances.Dispelling the wind and dampness pathogens lumbago and skelalgia, dysentery, edema, conjunctival congestion and swelling pain, laryngalgia, toothache, woman Female leucorrhea, carbuncle, scrofula；Caulis et Folium Kochiae: medicinal part is the young stem and leaf of chenopod Fructus Kochiae.Hardship, cold.Heat-clearing and toxic substances removing, diuresis is led to Drench.Controlling dysentery with red and white feces, have loose bowels, pyretic stranguria, conjunctival congestion, night blindness, skin wind heat is red swollen；The Rhizoma Atractylodis Macrocephalae: medicinal part is the dry of the feverfew Rhizoma Atractylodis Macrocephalae Dry rhizome.Bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is let out Rush down, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, tire Dynamic uneasiness；Stigma Maydis: basis, medicine source is style and the fresh idea of grass family Zea plant Zea mays.Sweet, light, flat.Return bladder, Liver, gallbladder meridian.Inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting.For acute and chronic nephritis, edema, acute hepatitis, chronic hepatitis, hypertension, diabetes, chronic Sinusitis, lithangiuria, Biliary Calculi, the disease such as dysuria, damp and hot jaundice.And habitual abortion can be prevented；Fructus Foeniculi: this product Dry mature fruit for samphire Fructus Foeniculi.Pungent, temperature.Return liver,kidney,spleen, stomach warp.Dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach.For trembling with fear Hernia is suffered from abdominal pain, the testis swelling and hanging down of either of the testes, dysmenorrhea, few abdomen cold type of pain, abdominal distention, lack of appetite and vomiting, hydrocele of testis.Salt Fructus Foeniculi warming the kidney cold expelling Pain relieving.Suffering from abdominal pain for colic of cold type, the testis swelling and hanging down of either of the testes, through cold stomachache；The Radix Linderae: medicinal part is the dried root of the canella Radix Linderae.It is pungent, Temperature.Return lung, spleen, kidney, bladder warp.Pleasant pain relieving, warming kidney for dispelling cold.For chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, the enuresis is urinated Frequently, hernia, dysmenorrhea；Bauhinia purpurea: this product is pulse family bauhinia Bauhinia purpurea, is used as medicine with root, bark, leaf and flower.Root: micro- Puckery, micro-cool.Bark: bitter, puckery is flat.Leaf: light is flat.Flower: light is cool.Root: hemostasis, spleen invigorating.For spitting blood, dyspepsia.Bark: The spleen strengthening and damp drying.For dyspepsia, acute gastroenteritis.Leaf: nourishing the lung to arrest cough.For coughing, constipation.Flower: antiinflammatory.For pneumonia, Bronchitis；Semen Citri grandis: this product is the seed of Citrus paradisi Macfadyen.Hardship, flat, temperature.Liver Channel depressed liver-energy dispersing and QI regulating, lung qi dispersing cough-relieving.Main hernia Lung cold cough；Russula vivesscens (Schaeff.) Franch.: medical material Ji Yuan is the sporophore of the green Russula of Russulaceae fungus.Sweet, micro-acid, cold in nature.Liver heat removing and eyesight improving, regulates the flow of vital energy Resolving depression.Main liver-heat conjunctival congestion, poor vision, women's depressing internal heat in liver, uncomfortable in chest does not relaxes；Radix seu Caulis Verntilaginis Leiocarpae: medicinal part is the Rhamnaceae plant wing The root of drupe, stem.Sweet, temperature.Benefiting vital QI and blood, dispelling, collateral-activating.Control deficiency of both QI and blood, rheumatalgia, traumatic injury；Radix potentillae anserinae: for Flos Rosae Multiflorae Section's potentilla plants Potentilla anserina L., is used as medicine with tuber.Sweet, flat.Fill blood, strengthening the spleen and stomach, promoting the production of body fluid to quench thirst, dampness removing.For disease Rear anemia, malnutrition, insufficiency of the spleen diarrhoea, rheumatic arthralgia；Radix Curcumae: this product is zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or fluffy The dried root of Rhizoma Curcumae.Pungent, bitter, cold.Return liver, the heart, lung meridian.Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, Chest and abdomen swelling and pain, twinge, calentura coma, epilepsy goes mad, jaundice dark coloured urine；Radix Ginseng: this product is the root of Araliaceae Radix Ginseng.Sweet in the mouth, Micro-hardship, warm in nature, flat.Return spleen, lung meridian, heart channel.QI invigorating, Gu de-, promote the production of body fluid, calm the nerves, Fructus Alpiniae Oxyphyllae.Cure mainly weak body and prostration, cold extremities faint pulse, spleen Empty lack of appetite, the deficiency of the lung breathes with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb；Heart failure, cardiogenic Shock.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hyperhidrosis, lack of appetite is unable, all acute and chronic diseases and stopping of causing after losing blood Gram, collapse.Strongly invigorating primordial QI, promotes the production of body fluid Gu de-, calms the nerves.Controlling impairment caused by overstrain deficient, lack of appetite, asthenia, food, stool lingering diarrhea, empty cough with asthma are told in regurgitation Promote, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, one Cut the card of qi-blood-body fluid deficiency；Radix Polygoni Multiflori: bitter sweet puckery, tepor.Enter liver, kidney channel.Nourishing the blood and yin, loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria, dispel the wind, Removing toxic substances.Main blood deficiency Light-headedness, cardiopalmus, insomnia, the soreness of the waist and knees of the hepatic and renal YIN deficiency, early whitening of beard and hair, tinnitus, seminal emission, dryness of the intestine constipation, Chronic malaria body is empty, rubella pruritus, carbuncle sore, scrofula, hemorrhoid；Radix Glycyrrhizae: medicinal part is that glycyrrhizic legume, Glycyrrhiza inflata Bat. or light fruit are sweet The dry root of grass and rhizome.Sweet in the mouth, property is put down.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, emergency is only Bitterly, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle skin ulcer Poison, cushion toxicity, strong.

Aleutian disease, also known as plasmacytosis, is a kind of to be drawn by the AD mainly encroaching on mink immunocyte Rise, cause self immune system disorderly and gradually exhaustion, the strongest autoimmune acute and chronic, infectiousness disease Sick.Acute case is very brief due to the course of disease, often can't see manifest symptom and sudden death.Chronic through out-of-date, sick ermine loss of appetite, Yearningly being intended to substantially increase, winter usually gnaws the ice cube in basin, becomes thin day by day, oral mucosa and gingiva bleeding gingival hemorrhage or have little burst Infections, feces is black coal tar shape, and sick ermine by hair slightly disorderly, tarnishes, and enophthalmos,enophthalmus is without god, and spirit is depressed, and drowsiness, gait is not Surely, anemia and exhaustion symptom are shown.When nervous system is encroached on, with tic, spasm, ataxia, hindlimb paralysis or Paresis.There is refusing to eat, carouses, shows strong thirsty desire, the most often declaration of death with uremia in the sick later stage.Ill Public beast, libido declines, or copulation incapability, necrospermia, few essence or produce teratospermia, and female ermine is infertile, or conceived miscarries and fetus Midway is absorbed.The young ermine of ill female ermine output, weakness, survival rate is low, it is easy to dead.

The pathological change of Aleutian disease is mainly manifested in kidney, spleen, lymph node, bone marrow and liver, especially kidney Change the most notable.The characteristic pathological changes of kidney is different according to stadium, and initial stage Kidney Volume increases (up to 2-3 times), gray or light Yellow, sometimes in khaki, there is yellow-white small lesion in surface, has petechial hemorrhage, later stage atrophy, and color is canescence.Liver Enlargement, from yellowish-brown or the khaki of the cinnamon red, red of acute process to chronic process, has been dispersed in canescence pin in essence The focus of point size, spleen enlargement, in kermesinus, chronic through out-of-date spleen atrophy, clear-cut margin, swollen lymph node, succulence, in Light gray.

In inventive formulation, Herba Camptosori Sibirici blood circulation promoting and blood stasis dispelling, hemostasis removing toxic substances, Radix Rubiae cooling blood for hemostasis, blood stasis dispelling stimulates the menstrual flow, and Radix Serissae dispels the wind Dampness removing, heat-clearing and toxic substances removing, Caulis et Folium Kochiae heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, phoenix bifurcation grass expelling wind and removing dampness, promoting blood circulation and stopping pain, heat-clearing and toxic substances removing, the Rhizoma Atractylodis Macrocephalae is good for Spleen QI invigorating, dampness diuretic, Stigma Maydis inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting, Radix Serissae, Caulis et Folium Kochiae, phoenix bifurcation grass share has heat-clearing and toxic substances removing Effect, coordinate Herba Camptosori Sibirici, Radix Berchemiae Giraldianae, Radix Rubiae blood circulation promoting and blood stasis dispelling, make unobstructed blood vessel, promote blood and lymph fluid circulation, make pyretic toxicity Quickly discharging with the circulation of blood, also the Rhizoma Atractylodis Macrocephalae, Stigma Maydis rush down turbid clear profit, and these medicine energy blood circulation promoting and blood stasis dispelling make meridians unimpeded, The evil detoxification of fall, rushes down that turbid clear profit is eliminating evil and the gas that is not impairment of the kidney, weeds out the old and bring forth the new again, improve renal blood flow, reduce blood urea nitrogen, serum creatinine, can It is obviously improved clinical symptoms, improves organism metabolism and immunologic function, accelerate the excretion of toxicant, stop the further of glomerule Infringement, is monarch drug altogether；Fructus Foeniculi dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach, the pleasant pain relieving of the Radix Linderae, warming kidney for dispelling cold, Bauhinia purpurea the spleen strengthening and damp drying, Fructus Citri grandis Core Liver Channel depressed liver-energy dispersing and QI regulating, lung qi dispersing cough-relieving, Russula vivesscens (Schaeff.) Franch. liver heat removing and eyesight improving, resolving depression of regulating the flow of vital energy, this five kinds of Chinese medicine share has warming the kidney and strengthening the spleen, soothing the liver The effect of resolving depression, fundamentally cures the pathological changes of kidney, spleen, lymph node and liver, consolidates righting, is ministerial drug altogether；Blood wind Rattan benefiting vital QI and blood, dispelling, collateral-activating, Radix potentillae anserinae fills blood, strengthening the spleen and stomach, promoting the production of body fluid to quench thirst, dampness removing, Radix Curcumae regulating qi to disperse stagnation, heart fire-clearing upset-relieving, profit Gallbladder jaundice eliminating, Ganoderma invigorating QI and tranquilization, ginseng qi-tonifying takes off admittedly, promotes the production of body fluid, Fructus Alpiniae Oxyphyllae of calming the nerves, Radix Polygoni Multiflori nourishing the blood and yin, loosening bowel to relieve constipation, solution of dispeling the wind Poison, Radix seu Caulis Verntilaginis Leiocarpae, Radix potentillae anserinae, Radix Curcumae benefiting qi and nourishing blood, Ganoderma, Radix Ginseng, Radix Polygoni Multiflori invigorating QI to relieve exhaustion, nourishing the blood and yin, be adjuvant drug altogether, and QI invigorating is supported Blood, admittedly take off YIN nourishing, adjust internal QI-blood circulation, improve circulatory function, improve organism metabolism and immunity；Radix Glycyrrhizae invigorating the spleen and replenishing QI, Heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, is for making medicine.The most all medicines coordinate and jointly play blood circulation promoting and blood stasis dispelling, clear Thermal detoxification, rush down turbid clear profit, warming the kidney and strengthening the spleen, dispersing the stagnated live-QI to relieve the stagnation of QI, benefiting qi and nourishing blood, effect of raising immunity of organisms, effectively prevent and treat mink AD.Side has been also added with the nutritional labelings such as Entermorpha, Semen adenantherae pavoninae, Semen Sesami Nigrum, Thallus Laminariae (Thallus Eckloniae), clam worm powder, fish scale, olive oil, its In, Entermorpha, rich in multiple nutritional components, has heat-clearing and toxic substances removing, anti-inflammation, enhancing human body immunity power, hard masses softening and resolving, detumescence profit The effect of urine, Semen adenantherae pavoninae heat extraction poison, diuresis, Semen Sesami Nigrum nourishing the liver and kidney, benefit blood intestine moistening, highlight hair color, Thallus Laminariae (Thallus Eckloniae) inducing diuresis to remove edema, carry High immunity, removes rubbish in intestinal, promotes mink feed, and fish scale contains rich in protein, fat and multivitamin, olive Olive oil can improve mink digestive system function, beneficially mink and digest and assimilate, and also has food calling effect.The present invention blood circulation promoting and blood stasis dispelling, Heat-clearing and toxic substances removing, rush down and treat Aleutian disease under the effect of turbid clear profit, warming the kidney and strengthening the spleen, dispersing the stagnated live-QI to relieve the stagnation of QI, benefiting qi and nourishing blood, strengthen simultaneously The resistance of mink body, moreover it is possible to promote mink feed, highlight because of the sick and hair color of dimness.

In the preparation method of the present invention, after material medicine composition is pulverized with the mixed liquor without sterilized water and ethanol 50 ± Soak 1h, the cell interior that sterilized water and ethanol molecule can be made to crush well into cell wall at 5 DEG C, fully infiltrate medical material, Making medical material when microwave extracting, microwave heating makes solvent sterilized water, toluene and ethanol absorb microwave energy and produces substantial amounts of heat energy Amount, makes intracellular temperature rise rapidly, and cell membrane and cell wall are broken through by the pressure of generation further, form some micro hole Hole, until crackle occurs in cell surface, makes solvent enter cell interior more fully, and microwave can also promote that the molecule in solvent is fast The rotation of speed and motion, especially water, these polar molecules of ethanol can produce moment under microwave action and intensify, generation key Vibration, tear and interparticle friction and collision, and it is quickly generated a large amount of heat energy, strong in cell interior penetration power, promote cell Continue to rupture, make the effective ingredient in Cell sap and medicine quickly overflow and diffuse to, in solvent, substantially reduce medicine effective The extraction time of composition, drastically increases extraction efficiency, and microwave heating is uniform, belongs to intraor extracellular and heats simultaneously, it is to avoid Thermograde during traditional extraction heating, medical material heated time is short, the beneficially extraction of effective ingredient in medical material.Additionally microwave Extraction can extract the effective ingredient in medical material in high volume, and solvent load is less than traditional handicraft simultaneously, facilitates in subsequent step Extract is concentrated and purifies, time-consuming；Extract is spray-dried and again dissolves after micronizing, can be after fine straining The impurity eliminated in Chinese medicine extract of limits.

Beneficial effects of the present invention:

(1) for Aleutian disease, present invention applicant have studied a kind of feed additive, by medicine food with the side mended It is sick that method treats this.Wherein Chinese medicine part is passed through blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, is rushed down turbid clear profit, warming the kidney and strengthening the spleen, dispersing the stagnated live-QI to relieve the stagnation of QI, benefit Gas nourishes blood, improves the method for immunity of organisms to treat AD.In formula, Radix Serissae, Caulis et Folium Kochiae, phoenix bifurcation grass share has The effect of heat-clearing and toxic substances removing, coordinates Herba Camptosori Sibirici, Radix Berchemiae Giraldianae, Radix Rubiae blood circulation promoting and blood stasis dispelling, makes unobstructed blood vessel, promote blood and lymph fluid to follow Ring, makes pyretic toxicity quickly discharge with the circulation of blood, and also the Rhizoma Atractylodis Macrocephalae, Stigma Maydis rush down turbid clear profit, and these medicine energy blood circulation promoting and blood stasis dispelling make Meridians are unimpeded, the evil detoxification of fall, rush down that turbid clear profit is eliminating evil and the gas that is not impairment of the kidney, weed out the old and bring forth the new again, improve renal blood flow, reduce blood urea nitrogen, Serum creatinine, can obviously improve clinical symptoms, improves organism metabolism and immunologic function, accelerates the excretion of toxicant, stops kidney little The further infringement of ball；Fructus Foeniculi dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach, the pleasant pain relieving of the Radix Linderae, warming kidney for dispelling cold, Bauhinia purpurea the spleen strengthening and damp drying, Semen Citri grandis Liver Channel depressed liver-energy dispersing and QI regulating, lung qi dispersing cough-relieving, Russula vivesscens (Schaeff.) Franch. liver heat removing and eyesight improving, resolving depression of regulating the flow of vital energy, this five kinds of Chinese medicine share have warming the kidney and strengthening the spleen, dredge The effect of liver resolving depression, fundamentally cures the pathological changes of kidney, spleen, lymph node and liver, consolidates righting；Radix seu Caulis Verntilaginis Leiocarpae tonification gas Blood, dispelling, collateral-activating, Radix potentillae anserinae fills blood, strengthening the spleen and stomach, promoting the production of body fluid to quench thirst, dampness removing, Radix Curcumae regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, spirit Sesame invigorating QI and tranquilization, ginseng qi-tonifying takes off admittedly, promotes the production of body fluid, Fructus Alpiniae Oxyphyllae of calming the nerves, Radix Polygoni Multiflori nourishing the blood and yin, loosening bowel to relieve constipation, removing toxic substances of dispeling the wind, blood wind Rattan, Radix potentillae anserinae, Radix Curcumae benefiting qi and nourishing blood, Ganoderma, Radix Ginseng, Radix Polygoni Multiflori invigorating QI to relieve exhaustion, nourishing the blood and yin, benefiting qi and nourishing blood, admittedly take off YIN nourishing, adjust Internal QI-blood circulation, improves circulatory function, improves organism metabolism and immunity；Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, only eliminates the phlegm Cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

(2) due to the reason such as Global climate change, body eutrophication, the ocean green tide of tangleweed Entermorpha is caused to break out, Entermorpha is floating in a large number gathers bank, blocks the fairway, destroys marine ecosystems, serious threat inshore fishing, tourist industry simultaneously Development, but containing carbohydrate containing, protein, crude fibre, aminoacid, fatty acid, vitamin and multi mineral in Entermorpha Matter, wherein iron content be recited as on Chinese food nutrient component meter China's food, Appropriate application of the present invention Entermorpha, no Address only the ecological nuclear sterile barley that Entermorpha raised growth brings, but also provide more rich nutrition for mink, improve The appetite of mink.

(3) each low raw-material cost of the feed additive preventing and treating Aleutian disease of the present invention, is readily available, is Green material, nontoxic to mink, do not contain chemical drugs or antibiotic, and effective ingredient is extracted into powder by the present invention End mixes in feed additive, and medicine can be absorbed by organisms rapidly, fast onset effect, to the controlling of mink suffering from AD Therapeutic effect is good, promotes the fast quick-recovery of mink, strengthens the immunity of mink, improves mink appetite, highlights mink hair color, be conducive to carrying The economic benefit of high raiser.

(4) in the preparation method of the present invention, after medicine is pulverized with the mixed liquor without sterilized water and ethanol at 50 ± 5 DEG C Soak 1h, the cell interior that sterilized water and ethanol molecule can be made to crush well into cell wall, fully infiltrate medical material so that medicine Material is when microwave extracting, and microwave heating makes solvent sterilized water, toluene and ethanol absorb microwave energy and produces substantial amounts of thermal energy, makes born of the same parents Interior temperature rises rapidly, and cell membrane and cell wall are broken through by the pressure of generation further, forms some small holes, until carefully There is crackle in cellular surface, makes solvent enter cell interior more fully, and microwave can also promote that the molecule in solvent quickly rotates With motion, especially water, these polar molecules of ethanol can produce moment under microwave action and intensify, produce the vibration of key, tear Split and interparticle friction and collision, and be quickly generated a large amount of heat energy, strong in cell interior penetration power, promote cell to continue broken Split, make the effective ingredient in Cell sap and medicine quickly overflow and diffuse to, in solvent, substantially reduce effective ingredient Extraction time, drastically increases extraction efficiency, and microwave heating is uniform, belongs to intraor extracellular and heats simultaneously, it is to avoid tradition Thermograde during extraction heating, medical material heated time is short, the beneficially extraction of effective ingredient in medical material.Additionally microwave extracting can With the effective ingredient in high-volume extraction medical material, solvent load is less than traditional handicraft simultaneously, and facilitating will extraction in subsequent step Liquid concentrates and purifies, time-consuming；Extract is spray-dried and again dissolves after micronizing, can be to greatest extent after fine straining The impurity eliminated in Chinese medicine extract.

(5) preparation method of the present invention is simple, easy to use, and overcoming primary disease can only be quarantined by repeatedly specificity, eliminates Sick ermine, purifies the traditional method of ermine field, is worth promoting.

Detailed description of the invention

Below in conjunction with embodiments of the invention, technical scheme is clearly and completely described.

Embodiment 1

A kind of feed additive preventing and treating the chronic AD of mink, is made up of each component of following parts by weight: Entermorpha 20 parts, Semen adenantherae pavoninae 20 parts, Semen Sesami Nigrum 10 parts, 20 parts of Thallus Laminariae (Thallus Eckloniae), clam worm powder 5 parts, 8 parts of fish scale, 6 parts of olive oil, Herba Camptosori Sibirici 20 parts, alizarin Grass 10 parts, Radix Serissae 8 parts, Caulis et Folium Kochiae 4 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Stigma Maydis 20 parts, Fructus Foeniculi 10 parts, the Radix Linderae 15 parts, Bauhinia purpurea 5 parts, Semen Citri grandis 5 parts, Russula vivesscens (Schaeff.) Franch. 4 parts, Radix seu Caulis Verntilaginis Leiocarpae 6 parts, Radix potentillae anserinae 6 parts, Radix Curcumae 10 parts, Radix Ginseng 10 parts, Radix Polygoni Multiflori 6 parts, 6 parts of Radix Glycyrrhizae.

The preparation method of the feed additive of the described preventing and treating chronic AD of mink, comprises the following steps:

(1) choose fresh Entermorpha, Thallus Laminariae (Thallus Eckloniae), fish scale, after cleaning up, after carrying out vacuum lyophilization, pulverize, cross 100 Mesh mesh screen, obtains mixed powder A；

(2) after Semen adenantherae pavoninae, the little fire of Semen Sesami Nigrum being fried, pulverize, cross 100 mesh mesh screens, obtain mixed powder B；

(3) by Herba Camptosori Sibirici, Radix Rubiae, Radix Serissae, Caulis et Folium Kochiae, the Rhizoma Atractylodis Macrocephalae, Stigma Maydis, Fructus Foeniculi, the Radix Linderae, Bauhinia purpurea, Semen Citri grandis, green grass or young crops Grinding to 80 mesh after head bacterium, Radix seu Caulis Verntilaginis Leiocarpae, Radix potentillae anserinae, Radix Curcumae, Radix Ginseng, Radix Polygoni Multiflori, Radix Glycyrrhizae mixing, gross weight is designated as 1 part, adds 3 parts of sterilized water, 1 part of ethanol, soak 1h, then be collectively disposed in microwave extracting tank by said medicine and liquid at 50 ± 5 DEG C Row extraction, control microwave frequency is 1000MHz, and microwave power is 100W/L, carries out microwave radiation, then by the work in extractor Making pressure to step up in 5-10min to 0.3MPa, microwave irradiation time amounts to 30min, obtains extract；

(4) after the extract of step (3) being decompressed, filter, reclaim ethanol, collect filtrate, filtrate is spray-dried, in obtaining Medicated powder；

(5) mixed powder A, mixed powder B and the Chinese medicine powder that clam worm powder, olive oil are obtained respectively with step (1), (2), (4) Mix homogeneously, sterilizing, obtain the feed additive of the described preventing and treating chronic AD of mink.

Embodiment 2

A kind of feed additive preventing and treating the chronic AD of mink, is made up of each component of following parts by weight: Entermorpha 40 parts, Semen adenantherae pavoninae 30 parts, Semen Sesami Nigrum 20 parts, 30 parts of Thallus Laminariae (Thallus Eckloniae), clam worm powder 15 parts, 16 parts of fish scale, 8 parts of olive oil, Herba Camptosori Sibirici 30 parts, 18 parts of Radix Rubiae, Radix Serissae 18 parts, Caulis et Folium Kochiae 10 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Stigma Maydis 30 parts, Fructus Foeniculi 20 parts, the Radix Linderae 25 parts, Bauhinia purpurea 15 parts, Semen Citri grandis 10 parts, Russula vivesscens (Schaeff.) Franch. 8 parts, Radix seu Caulis Verntilaginis Leiocarpae 10 parts, Radix potentillae anserinae 10 parts, Radix Curcumae 20 parts, Radix Ginseng 20 parts, Radix Polygoni Multiflori 12 parts, Radix Glycyrrhizae 12 parts.

The preparation method of the present embodiment is identical with the preparation method of embodiment 1.

Embodiment 3

A kind of feed additive preventing and treating the chronic AD of mink, is made up of each component of following parts by weight: Entermorpha 30 parts, Semen adenantherae pavoninae 25 parts, Semen Sesami Nigrum 15 parts, 25 parts of Thallus Laminariae (Thallus Eckloniae), clam worm powder 10 parts, 12 parts of fish scale, 7 parts of olive oil, Herba Camptosori Sibirici 25 parts, 14 parts of Radix Rubiae, Radix Serissae 13 parts, Caulis et Folium Kochiae 7 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Stigma Maydis 25 parts, Fructus Foeniculi 15 parts, the Radix Linderae 20 parts, Bauhinia purpurea 10 parts, Semen Citri grandis 8 parts, Russula vivesscens (Schaeff.) Franch. 6 parts, Radix seu Caulis Verntilaginis Leiocarpae 8 parts, Radix potentillae anserinae 8 parts, Radix Curcumae 15 parts, Radix Ginseng 15 parts, Radix Polygoni Multiflori 9 parts, 9 parts of Radix Glycyrrhizae.

The preparation method of the present embodiment is identical with the preparation method of embodiment 1.

Embodiment 4 controlling experiment

EXPERIMENTAL DESIGN and packet: select the close adult mink of 40 body weight, health status as test mink, these 40 Test mink through counter immunoelectrophoresis method detect all in AD incubation period, test mink is randomly divided into 4 groups, often Organize 10 minks.Often group carries out following operation after being normally carried out feeding:

First group: for blank group, use every day normal feedstuff to carry out feeding.

Second group: feed additive embodiment 1 prepared is thrown something and fed after mixing homogeneously with the ratio of 1:20 with normal feedstuff, One day three times.

3rd group: feed additive embodiment 2 prepared is thrown something and fed after mixing homogeneously with the ratio of 1:15 with normal feedstuff, One day three times.

4th group: feed additive embodiment 3 prepared is thrown something and fed after mixing homogeneously with the ratio of 1:10 with normal feedstuff, One day three times.

Log after one month:

Test index:

Clinical health and analyse observation: observational record experiment the every day mental status of mink, appetite, feces situation. If any mink death in test, then anatomic observation pathological change in time, often organize after off-test and slaughter 3 dead minks at random Observe pathological changes.

Test mink morbidity death condition is shown in Table 1.

Table 1 is fallen ill death condition

Group	Test number/only	Morbidity number/only	Sickness rate	Death toll/only	Mortality rate
						First group	10	10	90%	7	70%
Second group	10	1	20%	1	10%
						3rd group	10	1	0	0	0
4th group	10	0	0	0	0

From the data of table 1 it can be seen that four groups of minks, the feed additive of the present invention is mixed in feeding in normal feedstuff Second and third, the M & M of the mink of four groups is significantly lower than the mink of be not added with feed additive first group, morbidity Rate is less than 10%, and mortality rate, below 10%, minimum can reach zero death rate.

Test mink situation every day and anatomic observation pathological change:

First group: the phenomenon that appetite fails all occurred at about the 10th day in all minks, and spirit is depressed, thirsty, gradually disappears Thin, there were 3 mink death when the 16th day, mink feces of dying of illness presents coal tar oil sample, extremely becomes thin, and dissects and finds that internal organs store up out Blood, renomegaly, in Passeris montani saturati plaque-like, hepatomegaly, in yellowish-brown, until within the 30th day, there being 7 mink death, remain 3 minks extremely Become thin, be unwilling to take food.

Second group: had a mink that appetite decline, the not good phenomenon of spirit occur at about the 15th day, extreme thirst, About the 25th day, this mink was dead, dissects and finds renomegaly, in Passeris montani saturati plaque-like, the most dead to other minks when the 30th day.

3rd group: had a mink that appetite decline, the not good phenomenon of spirit occur at about the 10th day, extreme thirst, About the 20th day, this mink appetite was good at, mental restoration, the most dead to other minks when the 30th day.

4th group: in 30 days of test, untoward reaction do not occur in all minks.

The above is the preferred embodiment of the present invention, its object is to allow person skilled in the art understand the present invention Content is also carried out, it is noted that for those skilled in the art, without departing from the principle of the invention Under premise, it is also possible to make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.

Claims (5)

1. the feed additive preventing and treating the chronic AD of mink, it is characterised in that by each component of following parts by weight Make: Entermorpha 20-40 part, Semen adenantherae pavoninae 20-30 part, Semen Sesami Nigrum 10-20 part, Thallus Laminariae (Thallus Eckloniae) 20-30 part, clam worm powder 5-15 part, fish scale 8- 16 parts, olive oil 6-8 part, Herba Camptosori Sibirici 20-30 part, Radix Rubiae 10-18 part, Radix Serissae 8-18 part, Caulis et Folium Kochiae 4-10 part, Rhizoma Atractylodis Macrocephalae 12- 18 parts, Stigma Maydis 20-30 part, Fructus Foeniculi 10-20 part, Radix Linderae 15-25 part, Bauhinia purpurea 5-15 part, Semen Citri grandis 5-10 part, Russula vivesscens (Schaeff.) Franch. 4- 8 parts, Radix seu Caulis Verntilaginis Leiocarpae 6-10 part, Radix potentillae anserinae 6-10 part, Radix Curcumae 10-20 part, Radix Ginseng 10-20 part, Radix Polygoni Multiflori 6-12 part, Radix Glycyrrhizae 6-12 part.

A kind of feed additive preventing and treating the chronic AD of mink the most as claimed in claim 1, it is characterised in that by following Each component of parts by weight is made: Entermorpha 20 parts, Semen adenantherae pavoninae 20 parts, Semen Sesami Nigrum 10 parts, 20 parts of Thallus Laminariae (Thallus Eckloniae), clam worm powder 5 parts, fish scale 8 Part, 6 parts of olive oil, Herba Camptosori Sibirici 20 parts, 10 parts of Radix Rubiae, Radix Serissae 8 parts, Caulis et Folium Kochiae 4 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Stigma Maydis 20 parts, Fructus Foeniculi Perfume 10 parts, the Radix Linderae 15 parts, Bauhinia purpurea 5 parts, Semen Citri grandis 5 parts, Russula vivesscens (Schaeff.) Franch. 4 parts, Radix seu Caulis Verntilaginis Leiocarpae 6 parts, Radix potentillae anserinae 6 parts, Radix Curcumae 10 parts, Radix Ginseng 10 Part, Radix Polygoni Multiflori 6 parts, 6 parts of Radix Glycyrrhizae.

A kind of feed additive preventing and treating the chronic AD of mink the most as claimed in claim 1, it is characterised in that by following Each component of parts by weight is made: Entermorpha 40 parts, Semen adenantherae pavoninae 30 parts, Semen Sesami Nigrum 20 parts, 30 parts of Thallus Laminariae (Thallus Eckloniae), clam worm powder 15 parts, fish scale 16 parts, 8 parts of olive oil, Herba Camptosori Sibirici 30 parts, 18 parts of Radix Rubiae, Radix Serissae 18 parts, Caulis et Folium Kochiae 10 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Stigma Maydis 30 parts, Fructus Foeniculi 20 parts, the Radix Linderae 25 parts, Bauhinia purpurea 15 parts, Semen Citri grandis 10 parts, Russula vivesscens (Schaeff.) Franch. 8 parts, Radix seu Caulis Verntilaginis Leiocarpae 10 parts, Radix potentillae anserinae 10 parts, Radix Curcumae 20 Part, Radix Ginseng 20 parts, Radix Polygoni Multiflori 12 parts, 12 parts of Radix Glycyrrhizae.

A kind of feed additive preventing and treating the chronic AD of mink the most as claimed in claim 1, it is characterised in that by following Each component of parts by weight is made: Entermorpha 30 parts, Semen adenantherae pavoninae 25 parts, Semen Sesami Nigrum 15 parts, 25 parts of Thallus Laminariae (Thallus Eckloniae), clam worm powder 10 parts, fish scale 12 parts, 7 parts of olive oil, Herba Camptosori Sibirici 25 parts, 14 parts of Radix Rubiae, Radix Serissae 13 parts, Caulis et Folium Kochiae 7 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Stigma Maydis 25 parts, Fructus Foeniculi 15 parts, the Radix Linderae 20 parts, Bauhinia purpurea 10 parts, Semen Citri grandis 8 parts, Russula vivesscens (Schaeff.) Franch. 6 parts, Radix seu Caulis Verntilaginis Leiocarpae 8 parts, Radix potentillae anserinae 8 parts, Radix Curcumae 15 parts, Radix Ginseng 15 parts, Radix Polygoni Multiflori 9 parts, 9 parts of Radix Glycyrrhizae.

5. the preparation side of the feed additive of the preventing and treating chronic AD of mink as described in any one of claim 1-4 Method, it is characterised in that comprise the following steps:

(1) choose fresh Entermorpha, Thallus Laminariae (Thallus Eckloniae), fish scale, after cleaning up, after carrying out vacuum lyophilization, pulverize, cross 100 mesh nets Sieve, obtains mixed powder A；

(2) after Semen adenantherae pavoninae, the little fire of Semen Sesami Nigrum being fried, pulverize, cross 100 mesh mesh screens, obtain mixed powder B；

(3) by Herba Camptosori Sibirici, Radix Rubiae, Radix Serissae, Caulis et Folium Kochiae, the Rhizoma Atractylodis Macrocephalae, Stigma Maydis, Fructus Foeniculi, the Radix Linderae, Bauhinia purpurea, Semen Citri grandis, blue or green head Grinding to 80 mesh after bacterium, Radix seu Caulis Verntilaginis Leiocarpae, Radix potentillae anserinae, Radix Curcumae, Radix Ginseng, Radix Polygoni Multiflori, Radix Glycyrrhizae mixing, gross weight is designated as 1 part, adds 3 Part sterilized water, 1 part of ethanol, soak 1h, then said medicine and liquid be collectively disposed in microwave extracting tank and carry out at 50 ± 5 DEG C Extraction, control microwave frequency is 1000MHz, and microwave power is 100W/L, carries out microwave radiation, then by the work in extractor Pressure steps up to 0.3MPa in 5-10min, and microwave irradiation time amounts to 30min, obtains extract；

(4) after the extract of step (3) being decompressed, filter, reclaim ethanol, collect filtrate, filtrate is spray-dried, obtains Chinese medicine Powder；

(5) mixed powder A, mixed powder B and Chinese medicine powder that clam worm powder, olive oil obtain respectively with step (1), (2), (4) are mixed Uniformly, sterilizing, obtain the feed additive of the described preventing and treating chronic AD of mink.