CN105995711A - Fructus phyllanthi compound preparation and preparation method thereof - Google Patents

Abstract

The invention discloses a fructus phyllanthi compound preparation and a preparation method thereof. The preparation is prepared from the following raw materials in percentage by mass: 30-65 percent of fructus phyllanthi, 2-5 percent of notoginseng flos, 3-5 percent of kudzuvine flowers, 3-8 percent of lycium ruthenicum, 6-12 percent of blueberry, 2-5 percent of polygonatum kingianum, 5-10 percent of rhodiola rosea, 8-15 percent of bitter gourds, 2-3 percent of black tea and a proper amount of honey water. The compound preparation has the advantages of high health-protecting effect, sweet aftertaste and the like, is stable in process, and is suitable for industrial large-scale production. The fructus phyllanthi compound preparation has the effects of clearing heat, removing toxicity, nourishing and moistening lung, nourishing stomach, protecting liver, nourishing skin, lowering hypertension, hyperlipidemia and hyperglycemia, enhancing memory, tonifying qi, boosting essence, refreshing, relieving fatigue, improving immunity, protecting heart and blood vessels and the like, is safe, does not have toxic or side effect, has the effects of regulating and treating liver, spleen, stomach and kidneys at the same time, and is suitable for people of all ages, and especially suitable for long-time taking by people with high working or studying stress.

Description

A kind of fructus phyllanthi compound preparation and preparation method thereof

Technical field

The present invention relates to a kind of fructus phyllanthi compound preparation and preparation method thereof, belong to biological product technical field.

Background technology

Development along with society, the live and work rhythm of people is constantly accelerated, pressure is the most increasing, pollution plus living environment, physical function is caused to decline, hypoimmunity, easily causes antibacterial, virus, fungus etc. and infects, often show as having a delicate constitution, the reduction of malnutrition, lethargy, fatigue and weak, appetite, sleep disorder etc..

At present, market exists the health product of numerous preventing and treating various diseases, but great majority all DeGrains or the comparison that takes effect are slow, even because of human body difference without health-care effect, can not meet numerous consumer demand.

Yunnan Fructus Canarii albi is a kind of nutritious fruit, containing abundant vitamin and mineral, is indispensable medicine food dual purpose plant resource in life.After phyllanthus emblica powder many employings fresh fruit in the market is squeezed the juice, convection drying becomes powder or with solvent, concentrate drying after the extraction of Yunnan Fructus Canarii albi is obtained extract, also has and obtains phyllanthus emblica powder by pulverizing after Fructus Phyllanthi lyophilizing.Although the phyllanthus emblica powder that above two kinds of methods obtain remains the major part Yunnan original composition of Fructus Canarii albi, but the phyllanthus emblica powder color obtained is more dim, mouthfeel is sour and astringent, the easy moisture absorption and can not well preserve；And pulverize after Fructus Phyllanthi lyophilizing and obtain phyllanthus emblica powder cost height, and the height that the powder effective ingredient of Unit Weight is not squeezed the juice or extracted.

If Yunnan Fructus Canarii albi is applied in effective medical health product, for various people's long-term taking, it is necessary.

Summary of the invention

For problems such as the current health product poor effect of solution or health-care effect are single, the present invention provides a kind of fructus phyllanthi compound preparation and preparation method thereof so that it is has health care effectiveness height, mouthfeel Hui Tian, complete function, safely and effectively, is suitable for the advantages such as long-term taking.

The present invention is realized by following technical proposal: a kind of fructus phyllanthi compound preparation, is made up of the raw material of following masses percentage ratio:

Yunnan Fructus Canarii albi 30～65%, flower of Radix Notoginseng 2～5%, Flos puerariae lobatae 3～5%, black Fructus Lycii 3～8%, blue berry 6～12%, P. kingianum 2～5%, Radix Rhodiolae 5～10%, Fructus Momordicae charantiae 8～15%, black tea 2～3%, hydromel are surplus, and the summation of said components is 100%.

The mixed solution that described hydromel is Mel and water is 1:0.5～1:0.8 in mass ratio.

Another object of the present invention is to provide the preparation method of a kind of fructus phyllanthi compound preparation, through following each step:

A, material preparation by following mass percent:

Yunnan Fructus Canarii albi 30～65%, flower of Radix Notoginseng 2～5%, Flos puerariae lobatae 3～5%, black Fructus Lycii 3～8%, blue berry 6～12%, P. kingianum 2～5%, Radix Rhodiolae 5～10%, Fructus Momordicae charantiae 8～15%, black tea 2～3%, hydromel are surplus, and the summation of said components is 100%；

B, by the Yunnan Fructus Canarii albi of step A through following operation:

(1) through routine disinfection after being cleaned by ripe wild Yunnan Fructus Canarii albi fresh fruit, then it is crushed to granularity less than 30 mesh, obtains slurry；

(2) in step (1) gained slurry, add the deionized water of 0.5～1 times of quality, and to regulate pH value be 6.8～7.1, it is separately added into Yunnan Fructus Canarii albi fresh fruit quality 0.2～the cellulase of 0.5% and Yunnan Fructus Canarii albi fresh fruit quality 0.8～the pectase of 1.5%, enzymolysis 24～36 hours at 35～38 DEG C；It is subsequently placed in enzyme denaturing 15～20min at 90 DEG C, obtains Yunnan Fructus Canarii albi enzymolysis solution；

(3) by step (2) gained Yunnan Fructus Canarii albi enzymolysis solution after solid-liquid separation, discard marc, obtain Yunnan Fructus Canarii albi enzymolysis clear liquid；

(4) by the filtering with microporous membrane that Fructus Canarii albi enzymolysis clear liquid aperture, step (3) gained Yunnan is 0.8～3 μm, gained filtrate is Yunnan olive extract；

C, by the flower of Radix Notoginseng of step A through following operation: by a bud just ready to burst Panax notoginseng flower bud clean after, at-30～-50 DEG C, lyophilization to moisture content is 5～7%, then through micronizing to 600～800 mesh, obtains notogenseng pollen；

D, by the Flos puerariae lobatae of step A through following operation: by a bud just ready to burst Flos puerariae lobatae flower bud clean after, at-30～-50 DEG C, lyophilization to moisture content is 5～7%, then through micronizing to 600～800 mesh, obtains Flos puerariae lobatae powder；

E, by the black Fructus Lycii of step A and blue berry through following operation: mix after the fresh Lycium ruthenicum Murr. of ripe high-quality and blue berry are cleaned, squeeze the juice again, then extracting juice is filtered through plate-and-frame filtration method, marc adds after the deionized water stirring of fresh Lycium ruthenicum Murr. and blue berry gross mass 0.5～1 times plate-and-frame filtration, extracting juice again；Merge twice gained juice, then remove solid after being performing centrifugal separation on, i.e. obtain the fruit juice clear liquid of black Fructus Lycii and blue berry；

F, by the P. kingianum of step A, Radix Rhodiolae, Fructus Momordicae charantiae and black tea through following operation: mix with black tea after P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae powder are broken to the coarse powder of 20 mesh, adding 8 times of mass concentrations is that the ethanol of 80～95v/v% is after reflux, extract, 60min, filter, take filtrate concentration removing ethanol and obtain extracting solution；Again in filtering residue add 4 times of quality deionized water be heated to boiling extract 30min, filter, take filtrate and merge with extracting solution, spray-dried after be crushed to 80 mesh, i.e. obtain the mixed extract of P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae and black tea；

G, the fruit juice clear liquid of step B gained Yunnan olive extract and step E gained black Fructus Lycii and blue berry is mixed after, lyophilization at-40～-50 DEG C, pulverize again and obtain extract powder, it is subsequently adding step C gained notogenseng pollen, step D gained Flos puerariae lobatae powder, step F gained P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae and the mixed extract of black tea, add hydromel after mixing and make soft material, pelletize with 14 eye mesh screens, with 16 eye mesh screen granulate after granulation, obtain fructus phyllanthi compound preparation.

In above-mentioned fructus phyllanthi compound preparation, add adjuvant routinely make the dosage form of conventional acceptance: such as effervescent tablet, bag tea agent, capsule, buccal tablet etc..

Wherein, Yunnan Fructus Canarii albi (Fusctusphyllanthi) have another name called Phyllanthus emblica L., it is Euphorbiaceae Euphorbiaceae LeaffloweryllanthusPlant Fructus PhyllanthiPhyllanthus embllca L.Fruit, as a kind of important medicine food dual purpose plant resource, have anti-cancer, antiinflammatory, blood fat reducing and atherosclerosis, antioxidation, defying age, protect the liver, antiulcer, diarrhea, immunomodulating, the effect such as removing toxic substances.

Flower of Radix Notoginseng be araliaceae ginseng plant Radix Notoginseng (Panax pseudoginsengWall.var. notoginseng(Burkill) Hoo et T seng) inflorescence, it is the part that in Radix Notoginseng Herb, arasaponin content is the highest, nature and flavor are sweet cool, have effect of heat clearing away, suppressing the hyperactive liver, blood pressure lowering, it is adaptable to the disease such as dizzy, dizzy, tinnitus, hypertension and acute pharyngolaryngitis.Flower of Radix Notoginseng can promote the protein synthesis in liver, kidney, testis and serum, and DNA (deoxyribonucleic acid) (DNA) synthesis to each organ-tissue has facilitation.Flower of Radix Notoginseng has the obvious curative effects of blood circulation promoting and blood stasis dispelling, eliminating blood stasis to promote regeneration of blood.Flower of Radix Notoginseng have significant heat-clearing and toxic substances removing, suppressing the hyperactive liver improving eyesight, fat-reducing, blood fat reducing, blood pressure lowering, antiinflammatory, pain relieving, hemostasis, anticancer, eliminate the phlegm, relieving asthma, sleeping, coronary dilating, antiallergic, eliminating toxin and beautifying the skin etc. effect of easing pain.It is mainly used in that heat clearing away, removing toxic substances, removing heat from blood, blood pressure lowering, tune fat, immunomodulating, blood circulation and channel invigorating, health preserving be anti-ageing, anti-inflammatory analgesic.

Flos puerariae lobatae be legume pueraria lobata (Pueraria lobata ( Willd .)Ohwi) flower, flower of Radix Puerariae nature and flavor: sweet, flat, nontoxic；" the southern regions of the Yunnan Province book on Chinese herbal medicine " is recorded and is controlled dizziness, the loathing of cold, high fever, relieving acute alcoholism and recuperating the spleen, wine dysentery, and diet is not thought, and chest and diaphragm is glutted, sends out oh, and vomiting acid expectorant, alcoholism injures one's stomach, and spits blood, and hematemesis, disappear heat." detailed outline " is recorded and is controlled discharging fresh blood stool.

Black Fructus Lycii (Lycium ruthenicum Murr.) be Solanaceae (Solanaceae) Lycium (Lycium L.) mature fruit of plant, for atropurpureus to black, lycium ruthenicum fruit contains a certain amount of essential fatty acid, alkaloid, phenols, protein, vitamin, and containing 18 kinds of essential amino acids and abundant trace element, additionally contain more reduction polysaccharide and colors, especially contain abundant natural procyanidins.Black Fructus Lycii is rich in polyphenols such as anthocyanin, and in ripe fresh fruit, anthocyanin is up to 380mg/100g；Additionally contain Flavonoid substances etc..The pharmacological action of black Fructus Lycii: (1) blood sugar lowering, resisting fatigue, raising immunity of organisms effect；(2) the anti-aging effect of antioxidation；(3) anticancer antitumor action.

Blue berry be Ericaceae (Ericaceae) Vaccinium (Vaccinium Spp) mature fruit of plant.Containing abundant nutritional labeling in Blueberry, it not only has good nutrition health-care functions, also has and prevents that cranial nerve is aging, heart tonifying, anticancer vessel softening, strengthens the functions such as human organism's immunity.In Blueberry in addition to conventional sugar, acid and Vc, also rich in mineral elements such as VE, VA, VB, SOD, arbutin, protein, anthocyanin, edible fiber and abundant K, Fe, Zn, Ca.The special dietary compositions such as anthocyanidin contained by blue berry, organic germanium, organic selenium, Arbutin, aminoacid, fruit acid are that any plant is the most incomparable, the anthocyanidin being especially made up of 16 kinds of bioflavonoids, has the physiologically active more superior than general Anthocyanin.Containing abundant anthocyanin (anthocyanidin) in the fruit of blue berry, mainly there are antibiotic effect, anti-radical action, anti-visual deterioration and arteriosclerosis and thrombotic effect.Blue berry has and prevents that cranial nerve is aging, vessel softening, hyperlipidemia and coronary heart disease etc., the immunity of human body that strengthens, anticancer, antioxidation, improves effect that vision, memory reinforcing etc. are multiple.

P. kingianum (Poly gonatum kingianum Coll. et Hemsl.), it is Liliaceae, the herbal dry rhizome of Polygonatum, Main Ingredients and Appearance is aspartic acid, homoserine, DAB, digitalis glucoside etc., sweet in the mouth, flat.There is invigorating the spleen and replenishing QI, moisten cardiopulmonary, effect of bone and muscle strengthening.Controlling deficient cold and heat, pulmonary tuberculosis hemoptysis, after being ill body void lack of appetite, muscles and bones is weak, rheumatalgia, wind favus disease.

Radix Rhodiolae (Rhodiola rosea L.) is dry root and the rhizome of crassulaceae plants Radix Rhodiolae, it is possible to QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae are nourished heart, improved looks, and has stimulation nervous system, increases the effects such as work efficiency, allaying tiredness and prevention high mountain disease.Because it has magical effect of strengthening healthy qi, benefiting qi and nourishing blood, YIN nourishing lung benefiting, the human body nonspecific resistance to destructive stimulus can be promoted, strengthen the adaptability of human body, oxygen through reinforcement inner cell spreads, or oxygen uses benefit, antioxidative ability, help and improve the adaptive faculty that anoxia is stimulated by health.Radix Rhodiolae for anti-cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change become silted up detumescence, antipyretic bring down a fever, nourish the effects such as vigour；It is used for outward treating traumatic injury and burn and scald.Radix Rhodiolae also has enhancing exercise tolerance, banishes fatigue, resists mountain area cold, antioxidation, anti-diabetic, anti-pneumonia；The effects such as anticancer property.

Fructus Momordicae charantiae is cucurbitaceous plant Fructus Momordicae charantiaeMomordica charantiaFruit.Fructus Momordicae charantiae abnormal smells from the patient is bitter, nontoxic, cold in nature, enters the heart, liver, spleen, lung meridian, has clearing away summer-heat and quenches one's thirst, detoxifies, improving eyesight, QI invigorating benefit essence, blood pressure lowering, blood fat, and energy saliva stimulating and gastric secretion can promote appetite, help digest.Cure mainly the diseases such as heatstroke, summer-heat excessive thirst, summer boil, miliaria too much, dysentery, skin ulcer swollen, conjunctivitis, conjunctival congestion and swelling pain, carbuncle erysipelas, burn and scald, oliguria.Fructus Momordicae charantiae contains the material of Charantin and similar insulin, has good hypoglycemic activity, is the ultimate food of diabetics.Bitter melon protein matter composition and vitamin C can improve the immunologic function of body, make immunocyte have the effect killing cancerous cell, have the effect such as prevention vitamin C deficiency, protection cell membrane, atherosclerosis, raising physical stress ability, cardioprotection；Succus Momordicae charantiae contains certain protein ingredient, can strengthen the huge ability of biting, effective to lymphosarcoma and leukemia clinically；The trypsin inhibitor extracted from bitter melon seed, can stop malignant growth with protease out secreted by anticancer.Fructus Momordicae charantiae, containing abundant vitamin B1, vitamin C and mineral, is eaten for a long time, can keep full of vitality, and treatment comedo is had the biggest benefit.

Black tea belongs to the teas that entirely ferments, and black tea there occurs the chemical reaction centered by tea polyphenols enzymatic oxidation in the course of processing, and the chemical composition change in fresh leaf is relatively big, and tea polyphenols reduces more than 90%, creates the new component such as theaflavin, thearubigins.Under black tea has a diuresis caffeine in black tea and aromatic substance acts on jointly, increase the blood flow of kidney, anti-inflammation and sterilization, the effects such as tired, replenishing body fluid and clearing away heat pathogen, removing toxic substances that disappear of refreshing oneself.Be conducive to getting rid of internal unnecessary lactic acid, uric acid (with gout about), too much salinity (relevant with hypertension) etc., heart disease can also be relaxed or edema that nephritis causes simultaneously, it is the most useful that bacillary dysentery and alimentary toxicosis patient drink black tea, also wound smeared by black tea of commonly using among the people, black tea can also hypermnesia, quench the thirst and relieve summer heat.

Mel is rich in vitamin A, vitamin B₁, vitamin B₂, vitamin B₆, vitamin C, vitamin D, vitamin K, nicotinic acid, pantothenic acid, folic acid, biotin, choline etc..Mel has the effects such as cosmetology, anti-inflammation, promotion tissue regeneration, facilitating digestion, raising immunity, protection cardiovascular, has good medical assistance effect for heart disease, hypertension, pneumonopathy, oculopathy, hepatopathy, dysentery, constipation, anemia, nervous system disease, gastric duodenal ulcer disease etc..

Advantage that the present invention possesses and effect: the prescription compatibility that the present invention uses is reasonable, complete function, safely and effectively, be suitable for long-term taking, has the advantages such as health care effectiveness height, mouthfeel Hui Tian, and process stabilizing, is suitable for the big production of industry.The fructus phyllanthi compound preparation that the present invention provides has heat-clearing and toxic substances removing, nourishing lung moistening, nourishing the stomach protects the liver, eliminating toxin and beautifying the skin, fall three-hypers, memory reinforcing, QI invigorating benefit are smart, the effects such as tired, aid digestion, raising immunity, protection cardiovascular that disappear of refreshing oneself.This fructus phyllanthi compound preparation safety has no side effect, and has the effect of liver, spleen, stomach, kidney simultaneously conditioning and treating, is suitable for each age groups, is particularly suitable for work or learning pressure big crowd such as is eaten for a long time at the feature.

Detailed description of the invention

Below in conjunction with embodiment, the present invention will be further described.

Embodiment 1

A, material preparation by following mass percent:

Yunnan Fructus Canarii albi 65%, flower of Radix Notoginseng 2%, Flos puerariae lobatae 3%, black Fructus Lycii 3%, blue berry 6%, P. kingianum 2%, Radix Rhodiolae 5%, Fructus Momordicae charantiae 8%, black tea 2%, hydromel are surplus, and the summation of said components is 100%；

Wherein, the mixed solution that hydromel is Mel and water is 1:0.5 in mass ratio；

B, by the Yunnan Fructus Canarii albi of step A through following operation:

(1) through routine disinfection after being cleaned by ripe wild Yunnan Fructus Canarii albi fresh fruit, then by crusher in crushing to granularity less than 30 mesh, slurry is obtained；

(2) in step (1) gained slurry, add the deionized water of 0.5 mass times, and to regulate pH value with disodium hydrogen phosphate and sodium dihydrogen phosphate be 6.8, it is separately added into cellulase and the pectase of Yunnan Fructus Canarii albi fresh fruit quality 0.8%, enzymolysis 36 hours at 35 DEG C of Yunnan Fructus Canarii albi fresh fruit quality 0.2%；It is subsequently placed in enzyme denaturing 15min at 90 DEG C, obtains Yunnan Fructus Canarii albi enzymolysis solution；

(3) by step (2) gained Yunnan Fructus Canarii albi enzymolysis solution after solid-liquid separation, discard marc, obtain Yunnan Fructus Canarii albi enzymolysis clear liquid；

(4) by the filtering with microporous membrane that Fructus Canarii albi enzymolysis clear liquid aperture, step (3) gained Yunnan is 0.8 μm, gained filtrate is Yunnan olive extract；

C, by the flower of Radix Notoginseng of step A through following operation: by a bud just ready to burst Panax notoginseng flower bud clean after, at-30 DEG C, lyophilization to moisture content is 5%, then through micronizing to 600 mesh, obtains notogenseng pollen；

D, by the Flos puerariae lobatae of step A through following operation: by a bud just ready to burst Flos puerariae lobatae flower bud clean after, at-30 DEG C, lyophilization to moisture content is 5%, then through micronizing to 600 mesh, obtains Flos puerariae lobatae powder；

E, by the black Fructus Lycii of step A and blue berry through following operation: mix after the fresh Lycium ruthenicum Murr. of ripe high-quality and blue berry are cleaned, squeeze the juice again, then extracting juice is filtered through plate-and-frame filtration method, marc adds plate-and-frame filtration, extracting juice again after the deionized water stirring of fresh Lycium ruthenicum Murr. and blue berry gross mass 0.5 times；Merge twice gained juice, then remove solid after being performing centrifugal separation on, i.e. obtain the fruit juice clear liquid of black Fructus Lycii and blue berry；

F, by the P. kingianum of step A, Radix Rhodiolae, Fructus Momordicae charantiae and black tea through following operation: mix with black tea after P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae powder are broken to the coarse powder of 20 mesh, adding 8 times of mass concentrations is that the ethanol of 80v/v% is after reflux, extract, 60min, filter, take filtrate concentration removing ethanol and obtain extracting solution；Again in filtering residue add 4 times of quality deionized water be heated to boiling extract 30min, filter, take filtrate and merge with extracting solution, spray-dried after be crushed to 80 mesh, i.e. obtain the mixed extract of P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae and black tea；

G, the fruit juice clear liquid of step B gained Yunnan olive extract and step E gained black Fructus Lycii and blue berry is mixed after, lyophilization at-40 DEG C, pulverize again and obtain extract powder, it is subsequently adding step C gained notogenseng pollen, step D gained Flos puerariae lobatae powder, step F gained P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae and the mixed extract of black tea, add hydromel after mixing and make soft material, pelletize with 14 eye mesh screens, with 16 eye mesh screen granulate after granulation, obtain fructus phyllanthi compound preparation.

Embodiment 2

A, material preparation by following mass percent:

Yunnan Fructus Canarii albi 50%, flower of Radix Notoginseng 3%, Flos puerariae lobatae 4%, black Fructus Lycii 5%, blue berry 8%, P. kingianum 3%, Radix Rhodiolae 8%, Fructus Momordicae charantiae 12%, black tea 2%, hydromel are surplus, and the summation of said components is 100%；

Wherein, the mixed solution that hydromel is Mel and water is 1:0.6 in mass ratio；

B, by the Yunnan Fructus Canarii albi of step A through following operation:

(1) through routine disinfection after being cleaned by ripe wild Yunnan Fructus Canarii albi fresh fruit, then by crusher in crushing to granularity less than 30 mesh, slurry is obtained；

(2) in step (1) gained slurry, add the deionized water of 0.8 mass times, and to regulate pH value with disodium hydrogen phosphate and sodium dihydrogen phosphate be 7, it is separately added into cellulase and the pectase of Yunnan Fructus Canarii albi fresh fruit quality 1.2%, enzymolysis 30 hours at 36 DEG C of Yunnan Fructus Canarii albi fresh fruit quality 0.3%；It is subsequently placed in enzyme denaturing 18min at 90 DEG C, obtains Yunnan Fructus Canarii albi enzymolysis solution；

(3) by step (2) gained Yunnan Fructus Canarii albi enzymolysis solution after solid-liquid separation, discard marc, obtain Yunnan Fructus Canarii albi enzymolysis clear liquid；

(4) by the filtering with microporous membrane that Fructus Canarii albi enzymolysis clear liquid aperture, step (3) gained Yunnan is 1.2 μm, gained filtrate is Yunnan olive extract；

C, by the flower of Radix Notoginseng of step A through following operation: by a bud just ready to burst Panax notoginseng flower bud clean after, at-40 DEG C, lyophilization to moisture content is 6%, then through micronizing to 700 mesh, obtains notogenseng pollen；

D, by the Flos puerariae lobatae of step A through following operation: by a bud just ready to burst Flos puerariae lobatae flower bud clean after, at-40 DEG C, lyophilization to moisture content is 6%, then through micronizing to 700 mesh, obtains Flos puerariae lobatae powder；

E, by the black Fructus Lycii of step A and blue berry through following operation: mix after the fresh Lycium ruthenicum Murr. of ripe high-quality and blue berry are cleaned, squeeze the juice again, then extracting juice is filtered through plate-and-frame filtration method, marc adds plate-and-frame filtration, extracting juice again after the deionized water stirring of fresh Lycium ruthenicum Murr. and blue berry gross mass 0.8 times；Merge twice gained juice, then remove solid after being performing centrifugal separation on, i.e. obtain the fruit juice clear liquid of black Fructus Lycii and blue berry；

F, by the P. kingianum of step A, Radix Rhodiolae, Fructus Momordicae charantiae and black tea through following operation: mix with black tea after P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae powder are broken to the coarse powder of 20 mesh, adding 8 times of mass concentrations is that the ethanol of 90v/v% is after reflux, extract, 60min, filter, take filtrate concentration removing ethanol and obtain extracting solution；Again in filtering residue add 4 times of quality deionized water be heated to boiling extract 30min, filter, take filtrate and merge with extracting solution, spray-dried after be crushed to 80 mesh, i.e. obtain the mixed extract of P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae and black tea；

G, the fruit juice clear liquid of step B gained Yunnan olive extract and step E gained black Fructus Lycii and blue berry is mixed after, lyophilization at-45 DEG C, pulverize again and obtain extract powder, it is subsequently adding step C gained notogenseng pollen, step D gained Flos puerariae lobatae powder, step F gained P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae and the mixed extract of black tea, add hydromel after mixing and make soft material, pelletize with 14 eye mesh screens, with 16 eye mesh screen granulate after granulation, obtain fructus phyllanthi compound preparation.

Embodiment 3

A, material preparation by following mass percent:

Yunnan Fructus Canarii albi 30%, flower of Radix Notoginseng 5%, Flos puerariae lobatae 5%, black Fructus Lycii 8%, blue berry 12%, P. kingianum 5%, Radix Rhodiolae 10%, Fructus Momordicae charantiae 15%, black tea 3%, hydromel are surplus, and the summation of said components is 100%；

Wherein, the mixed solution that hydromel is Mel and water is 1:0.8 in mass ratio；

B, by the Yunnan Fructus Canarii albi of step A through following operation:

(1) through routine disinfection after being cleaned by ripe wild Yunnan Fructus Canarii albi fresh fruit, then by crusher in crushing to granularity less than 30 mesh, slurry is obtained；

(2) in step (1) gained slurry, add the deionized water of 1 mass times, and to regulate pH value with disodium hydrogen phosphate and sodium dihydrogen phosphate be 7.1, it is separately added into cellulase and the pectase of Yunnan Fructus Canarii albi fresh fruit quality 1.5%, enzymolysis 24 hours at 38 DEG C of Yunnan Fructus Canarii albi fresh fruit quality 0.5%；It is subsequently placed in enzyme denaturing 20min at 90 DEG C, obtains Yunnan Fructus Canarii albi enzymolysis solution；

(3) by step (2) gained Yunnan Fructus Canarii albi enzymolysis solution after solid-liquid separation, discard marc, obtain Yunnan Fructus Canarii albi enzymolysis clear liquid；

(4) by the filtering with microporous membrane that Fructus Canarii albi enzymolysis clear liquid aperture, step (3) gained Yunnan is 3 μm, gained filtrate is Yunnan olive extract；

C, by the flower of Radix Notoginseng of step A through following operation: by a bud just ready to burst Panax notoginseng flower bud clean after, at-50 DEG C, lyophilization to moisture content is 7%, then through micronizing to 800 mesh, obtains notogenseng pollen；

D, by the Flos puerariae lobatae of step A through following operation: by a bud just ready to burst Flos puerariae lobatae flower bud clean after, at-50 DEG C, lyophilization to moisture content is 7%, then through micronizing to 800 mesh, obtains Flos puerariae lobatae powder；

E, by the black Fructus Lycii of step A and blue berry through following operation: mix after the fresh Lycium ruthenicum Murr. of ripe high-quality and blue berry are cleaned, squeeze the juice again, then extracting juice is filtered through plate-and-frame filtration method, marc adds plate-and-frame filtration, extracting juice again after the deionized water stirring of fresh Lycium ruthenicum Murr. and blue berry gross mass 1 times；Merge twice gained juice, then remove solid after being performing centrifugal separation on, i.e. obtain the fruit juice clear liquid of black Fructus Lycii and blue berry；

F, by the P. kingianum of step A, Radix Rhodiolae, Fructus Momordicae charantiae and black tea through following operation: mix with black tea after P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae powder are broken to the coarse powder of 20 mesh, adding 8 times of mass concentrations is that the ethanol of 95v/v% is after reflux, extract, 60min, filter, take filtrate concentration removing ethanol and obtain extracting solution；Again in filtering residue add 4 times of quality deionized water be heated to boiling extract 30min, filter, take filtrate and merge with extracting solution, spray-dried after be crushed to 80 mesh, i.e. obtain the mixed extract of P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae and black tea；

G, the fruit juice clear liquid of step B gained Yunnan olive extract and step E gained black Fructus Lycii and blue berry is mixed after, lyophilization at-50 DEG C, pulverize again and obtain extract powder, it is subsequently adding step C gained notogenseng pollen, step D gained Flos puerariae lobatae powder, step F gained P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae and the mixed extract of black tea, add hydromel after mixing and make soft material, pelletize with 14 eye mesh screens, with 16 eye mesh screen granulate after granulation, obtain fructus phyllanthi compound preparation.

Take the fructus phyllanthi compound preparation of above-described embodiment 1,2,3, analyze for following health protection and therapeutic action:

One, subjects

Choose the age 4～following crowd 600 example of 80 years old: diabetes, hypertension, hyperlipidemia or coronary disease patient 100 example, lassitude, hypomnesis, uncomfortable in chest weak or symptom 100 examples such as few dormancy of having a sleepless night, climacteric syndrome or 100 examples of endocrine disturbance, acne, corse sweat pore, shallow complexion, face speckle person 100 example, person 100 example lower for the resistance, fatty liver, normal alcohol user 100 example.

It is randomly divided into test group and each 300 examples of matched group, wherein each 50 examples of diabetes, hypertension, hyperlipidemia or coronary disease patient, lassitude, hypomnesis, uncomfortable in chest weak or each 50 examples of symptom such as few dormancy of having a sleepless night, climacteric syndrome or each 50 examples of endocrine disturbance, acne, corse sweat pore, shallow complexion, face each 50 examples of speckle person, each 50 examples of person lower for the resistance, fatty liver, normal alcohol user 50 example.

Two, instructions of taking

In test group, each example all takes embodiment 1～3 gained fructus phyllanthi compound preparation, daily 2～3 times, each 0.5～2g；It serve on 21, observe and record result.

The patient of matched group hospital's prescription routinely is taken medicine or is not taken any medicine, continuous 21 days, observes and records result.

Three, result

The health-care effect of the fructus phyllanthi compound preparation that the present invention provides: the effective percentage of diabetes, hypertension, hyperlipidemia or coronary disease patient is reached 97.3%；Lassitude, hypomnesis, uncomfortable in chest weak or the symptoms such as few dormancy of having a sleepless night effective percentage are reached 88.1%；The effective percentage of the symptom such as climacteric syndrome or endocrine disturbance is reached 82.6%；Acne, corse sweat pore, shallow complexion, the effective percentage of face speckle person are reached 95.2%；The effective percentage of person lower for the resistance is reached 95.9%；Fatty liver, the effective percentage often drunk are reached 98.9%.And in constipation, lassitude, acne person, after taking 10, i.e. manifest symptom disappears or improves mostly.

And matched group reaches 38.2% to the effective percentage of diabetes, hypertension, hyperlipidemia or coronary disease patient；Lassitude, hypomnesis, uncomfortable in chest weak or the symptoms such as few dormancy of having a sleepless night effective percentage are reached 36.5%；The effective percentage of the symptom such as climacteric syndrome or endocrine disturbance is reached 45.9%；Acne, corse sweat pore, shallow complexion, the effective percentage of face speckle person are reached 41.6%；The effective percentage of person lower for the resistance is reached 52.6%；Fatty liver, the effective percentage often drunk are reached 69.4%.

Four, conclusion

The present invention provides fructus phyllanthi compound preparation to have heat-clearing and toxic substances removing, nourish lung moistening, eliminating phlegm and relieving asthma, suppressing the hyperactive liver improving eyesight, ease pain sleeping, eliminating toxin and beautifying the skin, fall three-hypers, memory reinforcing, QI invigorating benefit essence, the effects such as tired, aid digestion, raising immunity, protection cardiovascular that disappear of refreshing oneself.This fructus phyllanthi compound preparation has the effect of liver, spleen, stomach, kidney conditioning and treating simultaneously, the most without any side effects to old people and child, is suitable for each age groups, without any side effects.Its effect is better than matched group.

The prescription compatibility that the present invention uses is reasonable, complete function, safely and effectively, is suitable for long-term taking, has the advantages such as health care effectiveness height, mouthfeel Hui Tian, and process stabilizing, and applicable industry is big to be produced.

Claims (3)

1. a fructus phyllanthi compound preparation, it is characterised in that be made up of the raw material of following masses percentage ratio:

Yunnan Fructus Canarii albi 30～65%, flower of Radix Notoginseng 2～5%, Flos puerariae lobatae 3～5%, black Fructus Lycii 3～8%, blue berry 6～12%, P. kingianum 2～5%, Radix Rhodiolae 5～10%, Fructus Momordicae charantiae 8～15%, black tea 2～3%, hydromel are surplus, and the summation of said components is 100%.

Fructus phyllanthi compound preparation the most according to claim 1, it is characterised in that: the mixed solution that described hydromel is Mel and water is 1:0.5～1:0.8 in mass ratio.

3. the preparation method of a fructus phyllanthi compound preparation, it is characterised in that through following each step:

A, material preparation by following mass percent:

Yunnan Fructus Canarii albi 30～65%, flower of Radix Notoginseng 2～5%, Flos puerariae lobatae 3～5%, black Fructus Lycii 3～8%, blue berry 6～12%, P. kingianum 2～5%, Radix Rhodiolae 5～10%, Fructus Momordicae charantiae 8～15%, black tea 2～3%, hydromel are surplus, and the summation of said components is 100%；

B, by the Yunnan Fructus Canarii albi of step A through following operation:

(1) through routine disinfection after being cleaned by ripe wild Yunnan Fructus Canarii albi fresh fruit, then it is crushed to granularity less than 30 mesh, obtains slurry；

(2) in step (1) gained slurry, add the deionized water of 0.5～1 times of quality, and to regulate pH value be 6.8～7.1, it is separately added into Yunnan Fructus Canarii albi fresh fruit quality 0.2～the cellulase of 0.5% and Yunnan Fructus Canarii albi fresh fruit quality 0.8～the pectase of 1.5%, enzymolysis 24～36 hours at 35～38 DEG C；It is subsequently placed in enzyme denaturing 15～20min at 90 DEG C, obtains Yunnan Fructus Canarii albi enzymolysis solution；

(3) by step (2) gained Yunnan Fructus Canarii albi enzymolysis solution after solid-liquid separation, discard marc, obtain Yunnan Fructus Canarii albi enzymolysis clear liquid；

(4) by the filtering with microporous membrane that Fructus Canarii albi enzymolysis clear liquid aperture, step (3) gained Yunnan is 0.8～3 μm, gained filtrate is Yunnan olive extract；

C, by the flower of Radix Notoginseng of step A through following operation: by a bud just ready to burst Panax notoginseng flower bud clean after, at-30～-50 DEG C, lyophilization to moisture content is 5～7%, then through micronizing to 600～800 mesh, obtains notogenseng pollen；

D, by the Flos puerariae lobatae of step A through following operation: by a bud just ready to burst Flos puerariae lobatae flower bud clean after, at-30～-50 DEG C, lyophilization to moisture content is 5～7%, then through micronizing to 600～800 mesh, obtains Flos puerariae lobatae powder；

E, by the black Fructus Lycii of step A and blue berry through following operation: mix after the fresh Lycium ruthenicum Murr. of ripe high-quality and blue berry are cleaned, squeeze the juice again, then extracting juice is filtered through plate-and-frame filtration method, marc adds after the deionized water stirring of fresh Lycium ruthenicum Murr. and blue berry gross mass 0.5～1 times plate-and-frame filtration, extracting juice again；Merge twice gained juice, then remove solid after being performing centrifugal separation on, i.e. obtain the fruit juice clear liquid of black Fructus Lycii and blue berry；

F, by the P. kingianum of step A, Radix Rhodiolae, Fructus Momordicae charantiae and black tea through following operation: mix with black tea after P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae powder are broken to the coarse powder of 20 mesh, adding 8 times of mass concentrations is that the ethanol of 80～95v/v% is after reflux, extract, 60min, filter, take filtrate concentration removing ethanol and obtain extracting solution；Again in filtering residue add 4 times of quality deionized water be heated to boiling extract 30min, filter, take filtrate and merge with extracting solution, spray-dried after be crushed to 80 mesh, i.e. obtain the mixed extract of P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae and black tea；

G, the fruit juice clear liquid of step B gained Yunnan olive extract and step E gained black Fructus Lycii and blue berry is mixed after, lyophilization at-40～-50 DEG C, pulverize again and obtain extract powder, it is subsequently adding step C gained notogenseng pollen, step D gained Flos puerariae lobatae powder, step F gained P. kingianum, Radix Rhodiolae, Fructus Momordicae charantiae and the mixed extract of black tea, add hydromel after mixing and make soft material, pelletize with 14 eye mesh screens, with 16 eye mesh screen granulate after granulation, obtain fructus phyllanthi compound preparation.