CN105963862A - Needle-shaped photodynamic therapeutic device - Google Patents

Abstract

The invention provides a needle-shaped photodynamic therapy device, which includes an electroluminescent needle core, a transparent electrical insulating film sleeved on the outer surface of the needle core, and a conductive wire connected with the needle core. The needle core includes a needle shaft and a needle point , the electrical insulating film completely covers the needle core and is consistent with the shape of the needle. After the needle core is energized, the whole light emits light through the electrical insulating film and then irradiates the lesion. The needle core is a non-transparent rigid needle core. The present invention uses an electroluminescent needle core, which can emit light after being energized, and irradiates a large area of lesion after passing through a transparent electrical insulating film. Compared with traditional laser light sources, the cost of electroluminescent materials is lower, and The irradiated area is more flexible, and can be deep or shallow; no optical fiber is needed to conduct light, and the electroluminescence rigid needle core is used, which is not easy to break and break, and has good stability, which is more beneficial to the efficiency and safety of tumor treatment; and only needs It can emit light for treatment when it is powered on, which is easier to implement than treatment with laser as light source.

Description

A needle-shaped photodynamic therapy device

technical field

The invention belongs to the technical field of medical instruments, in particular to a needle-shaped photodynamic therapy device.

Background technique

The principle of photodynamic therapy (PDT) for treating malignant tumors is: during treatment, a photosensitizer is injected into blood vessels, and when it accumulates to a certain amount in the lesion of the tumor, a specific laser is used to irradiate the lesion to activate the photosensitizer and activate it. The photosensitizer releases a large amount of free radicals and singlet oxygen, destroys the cell structure of the diseased tissue, can lead to necrosis and shrinkage of the tumor tissue, and achieves the purpose of treatment. This therapy is a brand-new therapy with rapid development after surgery, radiotherapy, chemotherapy and immunotherapy. It has the characteristics of high specificity and less trauma, and has become one of the most active research fields in the world's tumor prevention and treatment science. However, due to the limitation of the penetration depth of light by cell tissue, the effective depth of the PDT light source is difficult to exceed several centimeters. This is its advantage and also its disadvantage. For diseases with superficial target tissues, such as superficial tumors of the skin and mucous membranes, port wine stains, macular degeneration, atherosclerosis, and psoriasis, photodynamic therapy can damage superficial targets well, while No damage to normal tissues. However, for deep tumors or large tumors, PDT is directly applied, and it is difficult for the light to penetrate deep into the tumor to eliminate the tumor. Therefore, the development of light sources and guiding instruments has an important impact on photodynamic therapy. For example, the emergence of optical fibers of various shapes can treat lesions of various shapes more conveniently and quickly. However, optical fibers are fragile and easy to break, and have certain unstable factors. Moreover, the main light source used in PDT at present is a laser, and the cost is relatively high. Therefore, it remains to be done to optimize light parameters according to clinical needs, and to develop some devices that are simple to operate, easy to use, stable in output, and cheap in price.

Contents of the invention

The main purpose of the present invention is to provide a needle-shaped photodynamic therapy device capable of penetrating into deep or large tumors, aiming at improving the stability of the therapy device itself, facilitating operation and reducing cost.

The present invention is achieved in this way, a needle-shaped photodynamic therapy device, comprising an electroluminescent needle core, a transparent electrical insulating film sleeved on the outer surface of the needle core, and a conductive wire connected to the needle core , the needle core includes a needle shaft and a needle point, the needle shaft and the needle point are integrally structured, the electrical insulation film completely covers the needle core and is consistent with the shape of the needle core, and the needle core emits light as a whole after being energized , the light irradiates the lesion after passing through the electrical insulating film, and the needle core is a non-transparent rigid needle core.

The present invention adopts an electroluminescent needle core, which can emit light after being energized, and can irradiate a large area of lesion after passing through a transparent electrical insulating film. Compared with traditional laser light sources, the cost of electroluminescent materials is lower, and The irradiation area is more flexible than the laser light source, and can be deep or shallow; no optical fiber is needed to transmit light, and the electroluminescence rigid needle core is used, which is not easy to break and break, and has good stability, which is more efficient and safe for tumor treatment It is beneficial; and it can be treated with light only by energizing, which is more convenient to implement than the treatment using laser as the light source.

Description of drawings

Fig. 1 is a schematic structural view of a needle-shaped photodynamic therapy device provided by an embodiment of the present invention;

Fig. 2 is a schematic diagram of a needle tip structure of a needle-shaped photodynamic therapy device provided by an embodiment of the present invention;

Fig. 3 is a schematic diagram of another needle tip structure of the needle-shaped photodynamic therapy device provided by the embodiment of the present invention.

detailed description

In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

It should be noted that when an element is referred to as being “fixed” or “disposed on” another element, it may be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element.

It should also be noted that the orientation terms such as left, right, up, and down in the embodiments of the present invention are only relative concepts or refer to the normal use state of the product, and should not be regarded as restrictive .

Please refer to accompanying drawing 1, the present invention provides a needle-shaped photodynamic therapy device, which is used to go deep into the interior of a deep or large tumor, and emit light to irradiate the accumulated photosensitizer in the lesion for photodynamic therapy. The photodynamic therapy device includes a needle core 01 made of electroluminescent material, a transparent electrical insulating film 02 sleeved on the outer surface of the needle core 01, and a conductive wire 04 connected to the needle core 01 and drawn from an external power source 03. The needle core 01 is a non-transparent rigid needle core, which includes a needle shaft 011 and a needle point 012. The needle shaft 011 and the needle point 012 are integrally structured. The electrical insulating film 02 is completely coated on the outside of the needle core 01 to protect the needle. The core 01 also isolates the needle core 01 from the human body tissue. Meanwhile, the electrical insulating film 02 has a smooth surface and high hardness for easy insertion into the body. In addition, the shape of the electrical insulating film 02 is consistent with that of the needle core 01, especially its tip is relatively Sharp for easy insertion into tumor interiors. Since the needle core 01 is made of electroluminescent material, it can emit light as a whole after being energized, and the light irradiates the lesion after passing through the electrical insulating film 02, and irradiates a large area to cause photosensitization of the photosensitizer gathered in the lesion. Produce the effect of killing tumor cells and achieve the purpose of treatment. In actual treatment, the choice of electroluminescent material is matched according to the photosensitizer used, and the needle-shaped photodynamic therapy device is a disposable product.

The embodiment of the present invention uses the needle core 01 made of electroluminescent material, which emits light after being energized and passes through the transparent electrical insulating film 02 to irradiate the lesion in a large area. Compared with the traditional laser light source, the cost of the electroluminescent material is lower Low, and the irradiation area is more flexible than the laser light source; no optical fiber is needed to transmit light, and the electroluminescent rigid needle core 01 is used, which is not easy to break and break, and has good stability, which is more beneficial to the efficiency and safety of tumor treatment ; And it can emit light for treatment only by energizing, which is more convenient to implement than the treatment using laser as the light source.

Furthermore, the electrical insulating film 02 used in this embodiment is a non-toxic organic ceramic electrical insulating film, which is environmentally friendly, transparent, and has no toxic and side effects on the human body. In addition, the needle core 01 is made of electroluminescent materials with strong mechanical strength and high luminous efficiency, which not only ensures its light intensity, but also ensures its rigidity and is not easy to break.

Further, the overall outer diameter of the needle-shaped photodynamic therapy device in this embodiment ranges from 0.03 to 5 mm, preferably 1 to 3 mm, wherein the wall thickness of the electrical insulating film 02 ranges from 0.01 to 1 mm, preferably from 0.25 to 1 mm. The total thickness range in the diameter direction of the needle body is 0.02-2mm, preferably 0.5-2mm, and the diameter range of the needle shaft 011 of the needle core 01 is 0.01-3mm, preferably 1-2.5mm, to ensure that the electrical insulation film 02 can The needle core 01 is fully protected, and the rigidity and luminous intensity of the needle core 01 meet the requirements, while the diameter of the needle body is avoided from being too large.

In this embodiment, the structure of the needle tip 012 can be, but not limited to, the following two structures, as shown in Figure 2 and Figure 3, one of which is the tip formed by tapering the end of the needle shaft 011, which is conical in appearance and can be Straight cones can also be oblique cones. The second is the tip formed by beveling the end of the needle bar 011 , which looks like a shape where an inclined plane intersects the side of the needle bar 011 . Other reasonable structures can also be adopted in other embodiments.

Further, in order to prevent the needle-shaped photodynamic therapy device from being polluted, a needle cap 05 is sheathed on the outside of the electrical insulating film 02, and it is packaged aseptically. The needle cap 05 is unpacked and sterilized before use during surgery.

The above are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements or improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention Inside.

Claims (6)

1. A needle-shaped photodynamic therapy device, characterized in that it comprises an electroluminescent needle core, a transparent electrical insulating film sleeved on the outer surface of the needle core, and a conductive wire connected with the needle core, The needle core includes a needle shaft and a needle point, the needle shaft and the needle point are integrally structured, the electrical insulating film completely covers the needle core and is consistent with the shape of the needle core, and the needle core emits light as a whole after electrification, The light irradiates the diseased part after passing through the electrical insulating film, and the needle core is a non-transparent rigid needle core. 2. The needle-shaped photodynamic therapy device according to claim 1, wherein the electrical insulation film is a non-toxic organic ceramic electrical insulation film. 3. needle-shaped photodynamic therapy device as claimed in claim 1 or 2, is characterized in that, the wall thickness scope of described electrical insulation film is 0.01-1mm, and the total thickness scope in its diameter direction is 0.02-2mm, so The diameter range of the needle shaft part of the needle core is 0.01-3mm. 4. The needle-shaped photodynamic therapy device according to claim 1 or 2, wherein the needle tip is a pointed portion formed by tapering the end of the needle shaft. 5. The needle-shaped photodynamic therapy device according to claim 1 or 2, wherein the needle point is a pointed portion formed by chamfering the end of the needle shaft. 6. The needle-shaped photodynamic therapy device according to claim 1 or 2, characterized in that a needle cap is sheathed on the outside of the electrical insulating film.