CN105920709A - Capsule breaking mechanism for dry powder inhalation delivery device - Google Patents
Capsule breaking mechanism for dry powder inhalation delivery device Download PDFInfo
- Publication number
- CN105920709A CN105920709A CN201610389658.5A CN201610389658A CN105920709A CN 105920709 A CN105920709 A CN 105920709A CN 201610389658 A CN201610389658 A CN 201610389658A CN 105920709 A CN105920709 A CN 105920709A
- Authority
- CN
- China
- Prior art keywords
- powder spray
- medicine bag
- dry powder
- powder inhalation
- capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002775 capsule Substances 0.000 title abstract description 15
- 239000000843 powder Substances 0.000 title abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 110
- 229940098458 powder spray Drugs 0.000 claims description 87
- 229940079593 drug Drugs 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 6
- 238000012377 drug delivery Methods 0.000 abstract 2
- 230000000149 penetrating effect Effects 0.000 abstract 1
- 208000018569 Respiratory Tract disease Diseases 0.000 description 5
- OBRNDARFFFHCGE-QDSVTUBZSA-N arformoterol fumarate Chemical compound OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@@H](C)NC[C@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@@H](C)NC[C@H](O)C1=CC=C(O)C(NC=O)=C1 OBRNDARFFFHCGE-QDSVTUBZSA-N 0.000 description 4
- 239000000428 dust Substances 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 3
- 239000000443 aerosol Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229960000193 formoterol fumarate Drugs 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 1
- -1 atomized inhalation Chemical compound 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0031—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a capsule breaking mechanism for a dry powder inhalation delivery device. The capsule breaking mechanism comprises a drug chamber accommodating a dry powder inhalation capsule and puncture needles penetrating through the inner wall of the drug chamber, wherein points of the puncture needles face inside of the drug chamber and are located in the position where the dry powder inhalation capsule is located; buttons are arranged at the other ends, located on the outer side of the drug chamber, of the puncture needles; the dry powder inhalation capsule is vertically placed by means of the drug chamber; the buttons are provided with at least two puncture needles; at least one puncture needle point is located at the upper end part of the dry powder inhalation capsule, at least the other puncture needle point is located at the lower end part of the dry powder inhalation capsule, and the puncture needle point located at the upper end part of the dry powder inhalation capsule is deviated relative to the puncture needle point located at the upper end part of the dry powder inhalation capsule. The two puncture needles on the buttons are vertically arranged and deviated laterally, the dry powder inhalation capsule is vertically arranged, so that the emptying rate of the dry powder inhalation capsule for drug delivery treatment is 100%, partial deviation of dry powder inhalation mixed gas concentration is smaller than 1%, and pre-and-post consistency of drug delivery treatment effect in the whole course of treatment is up to 99% or higher.
Description
Technical field
The present invention relates to technical field of medical instruments, particularly relate to the doser that a kind of powder spray for treating chronic respiratory tract disease sucks.
Background technology
Respiratory tract disease is a kind of commonly encountered diseases, and along with the deterioration of air quality, the sickness rate of respiratory tract disease is more and more higher, especially chronic respiratory tract disease, can bring, to patient, the pain that misery index is higher.Main, the most effective way for the treatment of chronic respiratory tract disease in Hospitals at Present have metered dose inhalation aerosol, Foradil Aerolizer formoterol fumarate, atomized inhalation, and Foradil Aerolizer formoterol fumarate is again powder spray, and the administration apparatus of powder spray is powder spray doser.
In prior art, the notification number such as Granted publication on the 28th in Patent Office of the People's Republic of China's November in 2007 is CN
The utility model patent of 200980876Y, a kind of dust cloud inhaler described in this patent, it is that two ends are respectively arranged with a root thorn capsule pricker and are furnished with the capsule type inhalation aerosol powder doser of air-flow booster, it is made up of lid, mouth haustorium, chassis and air-flow booster, two root thorn pins are individually fixed in the button of both sides, chassis, blister cavities and air-flow aperture constitute the air-flow booster being connected with chassis, and blister cavities is made by having resilient pliable material.These dust cloud inhalers are essentially all horizontal for powder spray medicine bag, a medicine outlet hole is respectively stung out at the two ends of medicine bag, by air-flow booster, medicine bag is rotated, powder spray is thrown away from medicine outlet hole and realizes administration by the centrifugal force utilizing medicine bag to rotate generation, owing to the medicine outlet hole of medicine bag is positioned at the end points at medicine bag two ends, the powder spray of medicine bag the latter half is difficult to throw away completely under gravity, also it is difficult to reach the uniform purpose of drug during throwing away, thus adverse effect can be brought to administering effect.
Summary of the invention
In order to overcome drawbacks described above, it is desirable to provide the Po Nang mechanism of a kind of powder spray doser, make the medicine outlet hole reasonable Arrangement of powder spray medicine bag, drug in the right direction, to guarantee powder spray medicine bag drug completely, uniformly, reach best therapeutic effect offer for patient and be effectively ensured.
The present invention solves the in-problem technical scheme of prior art: the Po Nang mechanism of a kind of powder spray doser, medicine storehouse and the pricker running through medicine storehouse inwall including built-in powder spray medicine bag, the tip of pricker is towards in medicine storehouse and be positioned at the position of powder spray medicine bag, the other end that pricker is positioned at outside medicine storehouse is provided with button, described medicine storehouse makes powder spray medicine bag uprightly place, described button at least has two pieces of prickers, at least one piece of lancet tip is positioned at the upper end of powder spray medicine bag, at least another piece of lancet tip is positioned at the bottom of powder spray medicine bag, it is positioned at the lancet tip of powder spray medicine bag upper end relative to being positioned at the lancet tip of powder spray medicine bag upper end to the left or right side biasing.The profile of powder spray medicine bag is typically middle cylindrically, two ends are spherical crown shape, uprightly being placed by powder spray medicine bag, do not sting out through hole at the upper and lower spherical cap portion of powder spray medicine bag, upper through hole is mainly used in air inlet, lower through-hole is mainly used in drug, so powder spray medicine bag rotates under the wind-force of air inlet drives, and powder spray throws away from lower through-hole under gravity, owing to upper through hole supplements air in time, negative pressure will not be produced so that powder spray can uniformly, be administered fully in powder spray medicine bag.Owing to being positioned at the lancet tip of powder spray medicine bag upper end, relative to the lancet tip being positioned at powder spray medicine bag upper end, to the left or right side biases, preferably, it is positioned at the lancet tip in spherical crown portion on powder spray medicine bag and is positioned at the plane both sides that the lancet tip in spherical crown portion under powder spray medicine bag divides the central shaft being listed in powder spray medicine bag central shaft and button above-below direction to be collectively forming, and it is positioned on powder spray medicine bag the pricker in spherical crown portion and to be positioned at the pricker in spherical crown portion under powder spray medicine bag all tangent with spherical crown portion inwall, so, the air entered from upper through hole can form spiral type whirlwind along powder spray medicine bag inwall, impact sticks to the powder spray on powder spray medicine bag inwall, make it come off, guarantee that powder spray is administered completely.
As preferably, described number of keys is two, and two buttons lay respectively at the both sides that medicine storehouse is relative.So when operating button, the active force of two buttons being positioned at medicine storehouse opposite sides can liquidate, and convenient for patients uses.
As preferably, the pricker configuration mode of said two button is consistent.So, not only there is good interchangeability, and the kind of accessory can be reduced, reduce manufacturing cost, ease of assembly.The upper lower through-hole that simultaneously can make powder spray medicine bag can be axially symmetric relative to powder spray medicine bag, is conducive to the uniformity being administered.
As preferably, in described medicine storehouse, it is provided with the cavity matched with powder spray medicine bag erectility.So may insure that powder spray medicine bag is kept upright state when rotated.
As preferably, described cavity inner wall is provided with through air inlet, and the axial side of air inlet inwall is tangent with the inwall of cavity.So, the air entered from air inlet can form spiral type whirlwind along cavity inner wall, and then promote powder spray medicine bag quickly to rotate, powder spray in powder spray medicine bag is thrown away by the centrifugal force utilizing powder spray medicine bag quickly to rotate generation from the lower through-hole of powder spray medicine bag, the powder spray simultaneously thrown away can be broken up by whirlwind again and form the drug treatment effect of uniform mixed gas, beneficially patient with air.
As preferably, the inwall in described medicine storehouse being circumferentially with multiple through hole, multiple through holes and the lancet tip being positioned at powder spray medicine bag upper end are in same plane.Multiple through holes on the inwall of medicine storehouse powder spray capsule rotate a circle can on through hole repeatedly give wind, powder spray medicine bag inwall produce multiple fitful wind formula whirlwind, it is ensured that powder spray is administered completely.
Compared with prior art, the method have the advantages that
Owing to two pieces of prickers on button of the present invention are arranged and left and right biasing up and down, powder spray medicine bag is upright, on make that powder spray medicine bag stings out two, through hole, two lower through-holes are respectively symmetrically and are positioned at powder spray medicine bag upper and lower spherical crown portion, and upper vent hole can repeatedly produce fitful wind formula spiral type whirlwind in powder spray medicine bag, so that the powder spray medicine bag Emptying Rate 100% of drug treatment, dust cloud mixed gas concentration partial deviations are less than 1%, and in the whole course for the treatment of, drug treatment effect self-consistentency is up to more than 99%.
Accompanying drawing explanation
Fig. 1 is a kind of structural upright schematic diagram of powder spray doser；
Fig. 2 is a kind of structural blast schematic diagram of powder spray doser；
Fig. 3 is the echelon sectional view in Chinese medicine storehouse of the present invention；
Fig. 4 is the schematic perspective view of button in the present invention；
Fig. 5 is the schematic front view of button in the present invention；
Fig. 6 is A-A cross-sectional schematic in Fig. 3；
Fig. 7 is B-B cross-sectional schematic in Fig. 3；
Fig. 8 is C-C cross-sectional schematic in Fig. 3.
In figure: suction nozzle 1, base 2, button 3, spring 4, medicine storehouse 5, through hole 6, pricker 7, air inlet 8, pricker hole 9, powder spray medicine bag 10, upper through hole 11, lower through-hole 12.
Detailed description of the invention
Below by specific embodiment, and combine accompanying drawing, the technical scheme of invention be described in further detail:
nullEmbodiment: the Po Nang mechanism of a kind of powder spray doser，Such as Fig. 1、Shown in Fig. 2，Including suction nozzle 1、Medicine storehouse 5、Spring 4、Button 3、Base 2，As shown in Figure 3，The cavity matched with powder spray medicine bag 10 erectility it is provided with in medicine storehouse 5，Powder spray medicine bag 10 is placed in cavity，Powder spray medicine bag 10 upper、Lower two ends are spherical crown shape，The centre of powder spray medicine bag 10 is cylindrically，Such as Fig. 2、Fig. 3、Shown in Fig. 4，Through pricker hole 9 it is provided with on the inwall of medicine storehouse 5，The button 3 being listed in medicine storehouse 5 two opposite outer is divided to be provided with two pieces of prickers 7，Pricker 7 runs through medicine storehouse 5 cavity inner wall by pricker hole 9，Wherein at the upper spherical crown of the most advanced and sophisticated alignment powder spray medicine bag 10 of one piece of pricker 7，At the lower spherical crown of the most advanced and sophisticated alignment powder spray medicine bag 10 of another piece of pricker 7，So，On powder spray medicine bag 10、Lower spherical crown portion can sting out through hole 11 respectively、Lower through-hole 12，Such as Fig. 3、Shown in Fig. 5，It is positioned on powder spray medicine bag 10 pricker 7 at spherical crown and is positioned at the pricker 7 points at 10 times spherical crowns of powder spray medicine bag and is listed in the both sides of the axis of symmetry that button 3 above-below direction extends，And it is equidistant with this axis of symmetry，Pricker 7 configuration mode of two buttons 3 is consistent，Such as Fig. 3、Shown in Fig. 6，On the inwall in medicine storehouse 5, circumference is evenly equipped with multiple through hole 6，Multiple through holes 6 are in same plane with the upper through hole 11 in spherical crown portion on powder spray medicine bag 10，Upper through hole 11 is tangent with the inwall of upper spherical crown，Such as Fig. 3、Shown in Fig. 7，What described cavity inner wall was relative is respectively provided on two sides with through air inlet 8，The axial side of air inlet 8 inwall is tangent with the inwall of cavity，Such as Fig. 3、Shown in Fig. 8，Lower through-hole 12 is tangent with the inwall of lower spherical crown.
The powder spray doser of the present invention through experimental verification, the result of detection is: the powder spray medicine bag Emptying Rate 100% of drug treatment, and dust cloud mixed gas concentration partial deviations are less than 1%, and in the whole course for the treatment of, drug treatment effect self-consistentency is up to more than 99%.
Embodiment described above is a kind of preferred version of the present invention, and the present invention not does any pro forma restriction, also has other variant and remodeling on the premise of without departing from the technical scheme described in claim.
The content not being described in detail in this specification, belongs to prior art known to those skilled in the art.
Claims (6)
1. the Po Nang mechanism of a powder spray doser, medicine storehouse and the pricker running through medicine storehouse inwall including built-in powder spray medicine bag, the tip of pricker is towards in medicine storehouse and be positioned at the position of powder spray medicine bag, the other end that pricker is positioned at outside medicine storehouse is provided with button, it is characterized in that: described medicine storehouse makes powder spray medicine bag uprightly place, described button at least has two pieces of prickers, at least one piece of lancet tip is positioned at the upper end of powder spray medicine bag, at least another piece of lancet tip is positioned at the bottom of powder spray medicine bag, it is positioned at the lancet tip of powder spray medicine bag upper end relative to being positioned at the lancet tip of powder spray medicine bag upper end to the left or right side biasing.
The Po Nang mechanism of powder spray doser the most according to claim 1, it is characterised in that: described number of keys is two, and two buttons lay respectively at the both sides that medicine storehouse is relative.
The Po Nang mechanism of powder spray doser the most according to claim 2, it is characterised in that: the pricker configuration mode of said two button is consistent.
4. according to the Po Nang mechanism of the arbitrary described powder spray doser of claims 1 to 3, it is characterised in that: it is provided with the cavity matched with powder spray medicine bag erectility in described medicine storehouse.
The Po Nang mechanism of powder spray doser the most according to claim 4, it is characterised in that: described cavity inner wall is provided with through air inlet, and the axial side of air inlet inwall is tangent with the inwall of cavity.
6. according to the Po Nang mechanism of the arbitrary described powder spray doser of claims 1 to 3, it is characterised in that: being circumferentially with multiple through hole on the inwall in described medicine storehouse, multiple through holes and the lancet tip being positioned at powder spray medicine bag upper end are in same plane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610389658.5A CN105920709B (en) | 2016-06-06 | 2016-06-06 | The Po Nang mechanism of powder spray drug delivery device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610389658.5A CN105920709B (en) | 2016-06-06 | 2016-06-06 | The Po Nang mechanism of powder spray drug delivery device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105920709A true CN105920709A (en) | 2016-09-07 |
| CN105920709B CN105920709B (en) | 2019-05-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610389658.5A Active CN105920709B (en) | 2016-06-06 | 2016-06-06 | The Po Nang mechanism of powder spray drug delivery device |
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| Country | Link |
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| CN (1) | CN105920709B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019101135A1 (en) * | 2017-11-23 | 2019-05-31 | 正大天晴药业集团股份有限公司 | Novel dry powder inhalation device |
| CN112494758A (en) * | 2020-11-06 | 2021-03-16 | 阿斯利康(无锡)贸易有限公司 | Medicine bag shearing mechanism and atomizing cup |
| WO2022218065A1 (en) * | 2021-04-16 | 2022-10-20 | 浙江萃泽医药科技有限公司 | Dry powder inhalation device and method for operating dry powder inhalation device |
| CN115814217A (en) * | 2023-02-14 | 2023-03-21 | 杭州希溪制药有限公司 | Powder inhalation apparatus |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2753402Y (en) * | 2004-12-17 | 2006-01-25 | 上海医药工业研究院 | Capsule dry-powder inhaling device |
| CN2933442Y (en) * | 2006-07-28 | 2007-08-15 | 李国华 | Double-air-passage inhalation device for medicament powder inhaler |
| CN200960345Y (en) * | 2006-10-17 | 2007-10-17 | 温明春 | Spring-inserting needle type dry powder inhalation device |
| CN102836487A (en) * | 2011-06-21 | 2012-12-26 | 北京万达创制科技有限公司 | Double-needle piercing type dry powder inhaler |
| CN205849935U (en) * | 2016-06-06 | 2017-01-04 | 浙江亿联健医疗器械有限公司 | The Po Nang mechanism of powder spray doser |
-
2016
- 2016-06-06 CN CN201610389658.5A patent/CN105920709B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2753402Y (en) * | 2004-12-17 | 2006-01-25 | 上海医药工业研究院 | Capsule dry-powder inhaling device |
| CN2933442Y (en) * | 2006-07-28 | 2007-08-15 | 李国华 | Double-air-passage inhalation device for medicament powder inhaler |
| CN200960345Y (en) * | 2006-10-17 | 2007-10-17 | 温明春 | Spring-inserting needle type dry powder inhalation device |
| CN102836487A (en) * | 2011-06-21 | 2012-12-26 | 北京万达创制科技有限公司 | Double-needle piercing type dry powder inhaler |
| CN205849935U (en) * | 2016-06-06 | 2017-01-04 | 浙江亿联健医疗器械有限公司 | The Po Nang mechanism of powder spray doser |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019101135A1 (en) * | 2017-11-23 | 2019-05-31 | 正大天晴药业集团股份有限公司 | Novel dry powder inhalation device |
| US11931506B2 (en) | 2017-11-23 | 2024-03-19 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Dry powder inhaler |
| CN112494758A (en) * | 2020-11-06 | 2021-03-16 | 阿斯利康(无锡)贸易有限公司 | Medicine bag shearing mechanism and atomizing cup |
| WO2022218065A1 (en) * | 2021-04-16 | 2022-10-20 | 浙江萃泽医药科技有限公司 | Dry powder inhalation device and method for operating dry powder inhalation device |
| CN115814217A (en) * | 2023-02-14 | 2023-03-21 | 杭州希溪制药有限公司 | Powder inhalation apparatus |
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| Publication number | Publication date |
|---|---|
| CN105920709B (en) | 2019-05-21 |
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Effective date of registration: 20190423 Address after: 317300 Tongjiang Road, Baita District, Xianju County Economic Development Zone, Taizhou City, Zhejiang Province Applicant after: Zhejiang Bai'an Medical Technology Co Ltd Address before: 317300 Room 402, Unit 1, 2 Buildings, Tianli International Hall, Chengguan, Xianju County, Taizhou City, Zhejiang Province Applicant before: Wang Tianxing |
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Effective date of registration: 20201019 Address after: 317300 industrial cluster area of Baita Town Xianju County Taizhou city Zhejiang Province Patentee after: ZHEJIANG E-LINKCARE MEDICAL TECHNOLOGY Co.,Ltd. Address before: Baita block Tong Jiang Road Economic Development Zone in Xianju County of Taizhou City, Zhejiang Province, No. 30 317300 Patentee before: ZHEJIANG BAIAN MEDICAL TECHNOLOGY Co.,Ltd. |
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