CN105920439A - Effective part composition containing corn stigma extract and preparation method and application of effective part composition - Google Patents
Effective part composition containing corn stigma extract and preparation method and application of effective part composition Download PDFInfo
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- CN105920439A CN105920439A CN201610437893.5A CN201610437893A CN105920439A CN 105920439 A CN105920439 A CN 105920439A CN 201610437893 A CN201610437893 A CN 201610437893A CN 105920439 A CN105920439 A CN 105920439A
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- 239000000284 extract Substances 0.000 title claims abstract description 67
- 239000000203 mixture Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 238000000605 extraction Methods 0.000 title claims description 13
- 240000008042 Zea mays Species 0.000 title abstract 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 title abstract 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 title abstract 3
- 235000005822 corn Nutrition 0.000 title abstract 3
- 239000000843 powder Substances 0.000 claims abstract description 36
- 210000000582 semen Anatomy 0.000 claims abstract description 11
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 10
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 10
- 235000008434 ginseng Nutrition 0.000 claims abstract description 10
- 240000008620 Fagopyrum esculentum Species 0.000 claims abstract description 9
- 235000009419 Fagopyrum esculentum Nutrition 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 56
- 108090000790 Enzymes Proteins 0.000 claims description 21
- 102000004190 Enzymes Human genes 0.000 claims description 21
- 229940088598 enzyme Drugs 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 18
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 10
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- 238000004108 freeze drying Methods 0.000 claims description 8
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- 238000006460 hydrolysis reaction Methods 0.000 claims description 8
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- 230000003276 anti-hypertensive effect Effects 0.000 claims description 6
- 238000001704 evaporation Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002386 leaching Methods 0.000 claims description 6
- 235000019359 magnesium stearate Nutrition 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 108010059892 Cellulase Proteins 0.000 claims description 4
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- 239000003814 drug Substances 0.000 claims description 4
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
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- 231100000252 nontoxic Toxicity 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/38—Sucrose-free products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses an effective part composition containing corn stigma extract and a preparation method and application of the effective part composition. The effective part composition is formed by using the corn stigma extract and white tea extract as main ingredients and adding ginseng powder, Chinese yam powder, Semen coicis powder and buckwheat powder. Raw materials are all natural plant resources which are both medicinal and edible and plant effective part extract, the effective part composition can be prepared into healthcare products various in dosage form, and the effective part composition has hypotensive efficacy, and is free of toxic and side effect if being drunk for a long time.
Description
Technical field
The present invention relates to containing Stigma Maydis extract application in food or health product, it is specifically related to a kind of with Stigma Maydis extract and Ramulus et Folium Mussaendae Pubescentis extract as main component, coordinates the application in food or health product of active component composition that the component of other several integration of edible and medicinal herbs obtains.
Background technology
Hypertension is modal cardiovascular disease, and a series of cardiovascular disease caused by it have become the No.1 disease affecting human health, are paid close attention to the most in the world.The western medicine hypertension method used clinically exists cures the symptoms, not the disease, and side effect is big, needs the drawbacks such as Long-term taking medicine, therefore in the urgent need to the safe and free of toxic and side effects pure natural health-care that can prevent and treat hypertension.
China's medicinal and edible plant is of a great variety, and research shows, many natural wild resources have the multiple compound health effect such as resisting hypertension, blood fat reducing.Wherein, Stigma Maydis just has significant hypertension and hyperlipemia effect, and pharmacological research shows: Stigma Maydis extract has diuresis, blood pressure lowering, promotion bile secretion, increases the effect such as thrombin and acceleration blood coagulation in blood, and meanwhile, Stigma Maydis also has the effect preventing and treating hypertension.Containing organized enzyme necessary to human body in Ramulus et Folium Mussaendae Pubescentis extract, domestic and international medical research proves that long-term drink Ramulus et Folium Mussaendae Pubescentis can improve internal fat activity, promotes catabolism of fat, effectively control amount of insulin secretion, the intestinal absorption of delay glucose, the sugar that in decomposer, blood is unnecessary, promote blood glucose balance.Meanwhile, Ramulus et Folium Mussaendae Pubescentis is containing abundant several amino acids, and it is cold, and having brings down a fever drives away summer heat the merit of removing toxic substances.
Summary of the invention
It is an object of the invention to the effect according to Stigma Maydis and Ramulus et Folium Mussaendae Pubescentis, there is provided a kind of new with Stigma Maydis extract and Ramulus et Folium Mussaendae Pubescentis extract as primary raw material, the natural plants effective part extract of other several integration of edible and medicinal herbs is added according to special ratios, obtained active component composition can make the health product of various dosage form, is especially possible for blood pressure lowering.
Another object of the present invention is to provide the preparation method of the above-mentioned active component composition containing Stigma Maydis extract.
It is also an object of the present invention to provide the application of the above-mentioned active component composition containing Stigma Maydis extract.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
A kind of active component composition containing Stigma Maydis extract, by forming according to the component of mass percentage as follows: Stigma Maydis extract 10～40%, Ramulus et Folium Mussaendae Pubescentis extract 10～40%, Radix Ginseng powder 5～10%, Rhizoma Dioscoreae powder 5～10%, Semen Coicis powder 5～10%, Fagopyrum esculentum Moench powder 5～10%；
Wherein, the preparation method of described Stigma Maydis extract is: Stigma Maydis is dried to constant weight, crosses leaching filtering residue after enzymolysis, then through alcohol extraction, takes filtrate, is dried, obtains Stigma Maydis extract after removing ethanol；
The preparation method of described Ramulus et Folium Mussaendae Pubescentis extract is: dries Ramulus et Folium Mussaendae Pubescentis to constant weight, then pulverizes and sieves, and extracts with ethanol solution, crosses leaching filtrate, is dried, obtains Ramulus et Folium Mussaendae Pubescentis extract after removing ethanol.
As the preferred technical scheme of one, above-mentioned enzymolysis is to use complex enzyme hydrolysis liquid that Stigma Maydis is carried out enzymolysis, described complex enzyme hydrolysis liquid is according to the formulated compound enzyme of the mass ratio of 1:1:1～3:1:1 by pectase, cellulase and hemicellulase, with water, compound enzyme being configured to concentration is 0.1～0.4wt%, and regulation pH is 3.0～5.0.
As one further optimal technical scheme, described enzymolysis is to be mixed according to the mass ratio of 1:1～1:6 with complex enzyme hydrolysis liquid by dried Stigma Maydis, enzymolysis 10～30min at 30～60 DEG C；Filtering residue is taken after enzymolysis, add the ethanol solution that volume fraction is 30～50%, filtering residue is 1:10～1:20 with the solid-liquid ratio of ethanol solution, 25～60 DEG C, under power 300～800W after supersound extraction 15～60min, cross leaching filtrate, rotate evaporating ethanol at 50 DEG C, then after vacuum lyophilization, obtain Stigma Maydis extract.
As the preferred technical scheme of one, in the preparation method of described Ramulus et Folium Mussaendae Pubescentis extract, described drying is 50 DEG C of drying, described sieving was 40～60 mesh sieves, the volume fraction of described ethanol solution is 50～80%, and the solid-liquid ratio of extraction is 1:10～1:20, and extraction temperature is 30～60 DEG C, extraction time is 2～3h, described is dried as vacuum lyophilization.
Active component composition containing Stigma Maydis extract of the present invention can be prepared as antihypertensive health care food or the antihypertensive health care medicine of various dosage form as required.
As a kind of optimal technical scheme, the present invention provides the method that above-mentioned active component composition is prepared as blood pressure lowering Tang: each raw material is crossed 80 mesh sieves respectively, then according to Stigma Maydis extract 10～40wt%, Ramulus et Folium Mussaendae Pubescentis extract 10～40wt%, Radix Ginseng powder 5～10wt%, Rhizoma Dioscoreae powder 5～10wt%, Semen Coicis powder 5～10wt%, the ratio mix homogeneously of Fagopyrum esculentum Moench powder 5～10wt%, add the PVP ethanol solution that volume fraction is 5%, cross 18 mesh sieve pelletizes, 16 mesh sieve granulate are crossed after pulverizing, the magnesium stearate 0.1～2wt% being subsequently adding, tabletting, sterilization, obtain the blood pressure lowering sugar containing Stigma Maydis extract.
Compared with prior art, there is advantages that
(1) present invention selects Stigma Maydis, Ramulus et Folium Mussaendae Pubescentis, Radix Ginseng, Rhizoma Dioscoreae, Semen Coicis, Semen Fagopyri Esculenti as raw material, is integration of edible and medicinal herbs and foodstuff, has certain antihypertensive effect, and long-term drink is to human non-toxic's side effect；
(2) effective ingredient in Stigma Maydis and Ramulus et Folium Mussaendae Pubescentis is extracted by the present invention, enhances the antihypertensive effect of product, and the process of extraction is simple, easy and simple to handle；
(3) active component composition of the present invention can make various dosage form, it is also possible to the method provided according to the present invention is prepared as blood pressure lowering sugar, has the advantages such as in good taste, taking convenience.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited in any form by embodiment.
In following example, if no special instructions, the raw material used is raw material the most on sale, and the method used is method well known to those skilled in the art.
Embodiment 1
(1) preparation of Stigma Maydis extract: Stigma Maydis 1kg is dried to constant weight in 50 DEG C of baking ovens；Meanwhile, preparing compound enzyme with hemicellulase mass ratio 1:1:1 according to pectase, cellulase, then with water, compound enzyme is formulated as the enzyme liquid that mass percent is 0.4%, the pH of regulatory enzyme liquid is 3.0；Dried Stigma Maydis is mixed according to the mass ratio of 1:1 with complex enzyme hydrolysis liquid, enzymolysis 30min at 30 DEG C；Stigma Maydis after enzymolysis is complete-compound enzyme mixed liquor filters, take filtering residue, add the ethanol solution of 30%, filtering residue is 1:10 with the solid-liquid ratio of ethanol solution, temperature 60 C, supersound extraction 15min under power draw 800W, filter, take filtrate, rotate evaporating ethanol at 50 DEG C, and carry out vacuum lyophilization and prepare Stigma Maydis extract 125g.
(2) preparation of Ramulus et Folium Mussaendae Pubescentis extract: Ramulus et Folium Mussaendae Pubescentis 1kg is dried to constant weight in 50 DEG C of baking ovens, rear pulverizing, cross 40 mesh sieves, at 60 DEG C, 2h is extracted with the ethanol of volume fraction 80%, obtaining Ramulus et Folium Mussaendae Pubescentis extracting solution, extracting solution carries out vacuum lyophilization after rotating evaporating ethanol at 50 DEG C and prepares Ramulus et Folium Mussaendae Pubescentis extract 158g.
(3) Stigma Maydis extract 40g, Ramulus et Folium Mussaendae Pubescentis extract 39.5g, Radix Ginseng powder 5g, Rhizoma Dioscoreae powder 5g, Semen Coicis powder 5g, Fagopyrum esculentum Moench powder 5g, magnesium stearate 0.5g.
(4) pelletize: Stigma Maydis extract, Ramulus et Folium Mussaendae Pubescentis extract, Radix Ginseng powder, Rhizoma Dioscoreae powder, Semen Coicis powder, Fagopyrum esculentum Moench powder cross 80 mesh sieves respectively, mix in proportion, add the PVP ethanol solution 20ml soft material that volume fraction is 5%, cross 18 mesh sieve pelletizes, dry under the conditions of 50 DEG C, pulverize, cross 16 mesh sieve granulate；
(5) tabletting: add magnesium stearate in granule, carry out tabletting, obtain pressed candy.
(6) sterilization: using ultra-vioket radiation sterilization, the time is 30min.
(7) detection: organoleptic indicator: the smooth surface of pressed candy, uniform color is consistent；Physical and chemical index: tablet weight 0.6g, moisture≤2.0%.
Embodiment 2
(1) preparation of Stigma Maydis extract: Stigma Maydis 1kg is dried to constant weight in 50 DEG C of baking ovens；Meanwhile, preparing compound enzyme with hemicellulase mass ratio 3:1:1 according to pectase, cellulase, then with water, compound enzyme is formulated as the enzyme liquid that mass percent is 0.1%, the pH of regulatory enzyme liquid is 5.0；Dried Stigma Maydis is mixed according to the mass ratio of 1:6 with complex enzyme hydrolysis liquid, enzymolysis 10min at 60 DEG C；Stigma Maydis after enzymolysis is complete-compound enzyme mixed liquor filters, take filtering residue, add the ethanol solution of 50%, filtering residue is 1:20 with the solid-liquid ratio of ethanol solution, temperature 25 DEG C, supersound extraction 60min under power 300W, filter, take filtrate, rotate evaporating ethanol at 50 DEG C, and carry out vacuum lyophilization and prepare Stigma Maydis extract 130g.
(2) preparation of Ramulus et Folium Mussaendae Pubescentis extract: Ramulus et Folium Mussaendae Pubescentis 1kg is dried to constant weight in 50 DEG C of baking ovens, rear pulverizing, cross 60 mesh sieves, at 30 DEG C, 3h is extracted with the ethanol of volume fraction 50%, obtaining Ramulus et Folium Mussaendae Pubescentis extracting solution, extracting solution carries out vacuum lyophilization after rotating evaporating ethanol at 50 DEG C and prepares Ramulus et Folium Mussaendae Pubescentis extract 150g.
(3) active component composition of 100g Stigma Maydis extract is prepared, its proportioning raw materials: Stigma Maydis extract 30g, Ramulus et Folium Mussaendae Pubescentis extract 30g, Radix Ginseng powder 8g, Rhizoma Dioscoreae powder 10g, Semen Coicis powder 10g, Fagopyrum esculentum Moench powder 10g, magnesium stearate 2g.
(4) pelletize: Stigma Maydis extract, Ramulus et Folium Mussaendae Pubescentis extract, Radix Ginseng powder, Rhizoma Dioscoreae powder, Semen Coicis powder, Fagopyrum esculentum Moench powder cross 80 mesh sieves respectively, mix in proportion, add the PVP ethanol solution 20ml soft material that volume fraction is 5%, cross 18 mesh sieve pelletizes, after pulverizing, cross 16 mesh sieve granulate；
(5) tabletting: add magnesium stearate in granule, carry out tabletting, obtain pure natural book on Chinese herbal medicine pressed candy.
(6) sterilization: using ultra-vioket radiation sterilization, the time is 30min.
(7) detection: organoleptic indicator: the smooth surface of pressed candy, uniform color is consistent；Physical and chemical index: tablet weight 0.6g, moisture≤2.0%.
Experimental example 1 blood pressure lowering is tested
Clinical observation patient is divided into 600 examples, and patient all has obvious hypertension clinical symptoms and makes a definite diagnosis through clinicist.
Patient is divided into 3 groups, and A group is the pressed candy of oral embodiment 1 gained, three times a day, each 2.Administration time is 15 days.The pressed candy that the oral embodiment of B group 2 prepares, three times a day, each 2.C group is blank.
After 15 days, the blood pressure data statistical result of patient is shown inTable 2。
Criterion of therapeutical effect: effective include two kinds of situations: the first declines more than 1.3KPa (10mmHg) for diastolic pressure, and reaches normal range；Though diastolic pressure does not drops to normally, but decline more than 2.6KPa (20mmHg).The second is that diastolic pressure declines not as good as 1.3KPa (10mmHg), but has reached normal range；Diastolic pressure declines 1.3～2.34KPa (10～19mmHg) before relatively treating, but does not reaches normal range；More than 4.0KP (30mmHg) is declined before shrinking pressure relatively treatment.Invalid: not up to effective standard.
Table
1
| Group | Number of cases | Effective | Invalid | Obvious effective rate |
| A | 200 | 198 | 2 | 99% |
| B | 200 | 195 | 5 | 97.5% |
| C | 200 | 0 | 0 | 0 |
Claims (7)
1. the active component composition containing Stigma Maydis extract, it is characterised in that described effective site combines
Thing is by forming according to the component of mass percentage as follows: Stigma Maydis extract 10～40%, Ramulus et Folium Mussaendae Pubescentis extract
10～40%, Radix Ginseng powder 5～10%, Rhizoma Dioscoreae powder 5～10%, Semen Coicis powder 5～10%, Fagopyrum esculentum Moench powder 5～10%；
Wherein, the preparation method of described Stigma Maydis extract is: Stigma Maydis is dried to constant weight, mistake after enzymolysis
Leaching filtering residue, then through alcohol extraction, take filtrate, it is dried after removing ethanol, obtains Stigma Maydis extract；
The preparation method of described Ramulus et Folium Mussaendae Pubescentis extract is: dries Ramulus et Folium Mussaendae Pubescentis to constant weight, then pulverizes and sieves, use second
Alcoholic solution extracts, and crosses leaching filtrate, is dried, obtains Ramulus et Folium Mussaendae Pubescentis extract after removing ethanol.
Active component composition containing Stigma Maydis extract the most according to claim 1, it is characterised in that
Described enzymolysis be use complex enzyme hydrolysis liquid Stigma Maydis is carried out enzymolysis, described complex enzyme hydrolysis liquid be by pectase,
Cellulase and hemicellulase, will be compound with water according to the formulated compound enzyme of the mass ratio of 1:1:1～3:1:1
It is 0.1～0.4wt% that enzyme is configured to concentration, and regulation pH is 3.0～5.0.
Active component composition containing Stigma Maydis extract the most according to claim 2, it is characterised in that
Described enzymolysis is to be mixed according to the mass ratio of 1:1～1:6 with complex enzyme hydrolysis liquid by dried Stigma Maydis,
Enzymolysis 10～30min at 30～60 DEG C；Take filtering residue after enzymolysis, add the ethanol solution that volume fraction is 30～50%,
The solid-liquid ratio of filtering residue and ethanol solution is 1:10～1:20,25～60 DEG C, ultrasonic under power 300～800W carry
After taking 15～60min, cross leaching filtrate, at 50 DEG C, rotate evaporating ethanol, then after vacuum lyophilization,
Obtain Stigma Maydis extract.
Active component composition containing Stigma Maydis extract the most according to claim 1, it is characterised in that
In the preparation method of described Ramulus et Folium Mussaendae Pubescentis extract, described drying is 50 DEG C of drying, described in sieve be 40～60 mesh
Sieve, the volume fraction of described ethanol solution is 50～80%, and the solid-liquid ratio of extraction is 1:10～1:20, extraction temperature
Degree is 30～60 DEG C, and extraction time is 2～3h, described is dried as vacuum lyophilization.
5. Claims 1 to 4 contains described in any one claim the effective site combination of Stigma Maydis extract
Thing application in preparing antihypertensive health care food or antihypertensive health care medicine.
The application of the active component composition containing Stigma Maydis extract the most according to claim 5, it is special
Levy and be the described active component composition containing Stigma Maydis extract is made blood pressure lowering sugar.
The application of the active component composition containing Stigma Maydis extract, its feature the most according to claim 6
It is that the preparation method of described confection is that each raw material is crossed 80 mesh sieves respectively, then according to Stigma Maydis extract
10～40wt%, Ramulus et Folium Mussaendae Pubescentis extract 10～40wt%, Radix Ginseng powder 5～10wt%, Rhizoma Dioscoreae powder 5～10wt%, Semen Coicis
Core powder 5～10wt%, the ratio mix homogeneously of Fagopyrum esculentum Moench powder 5～10wt%, adding volume fraction is the PVP of 5%
Ethanol solution, crosses 18 mesh sieve pelletizes, crosses 16 mesh sieve granulate, the magnesium stearate being subsequently adding after pulverizing
0.1～2wt%, tabletting, sterilization, obtain the blood pressure lowering sugar containing Stigma Maydis extract.
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| CN108030090A (en) * | 2017-11-14 | 2018-05-15 | 广州市澳键丰泽生物科技股份有限公司 | A kind of energy extract and its preparation method and application |
| CN109056372A (en) * | 2018-06-27 | 2018-12-21 | 阜南美凯服饰有限公司 | A kind of coloring agent for cotton synthetic fibre fabric |
| CN111150811A (en) * | 2019-12-19 | 2020-05-15 | 艾散·阿尤普 | A kind of formula of hypoglycemic powder |
| CN113520888A (en) * | 2021-07-15 | 2021-10-22 | 广东雷诺化妆品研究院有限公司 | A kind of anti-aging composition containing fullerene and its preparation method and application |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108030090A (en) * | 2017-11-14 | 2018-05-15 | 广州市澳键丰泽生物科技股份有限公司 | A kind of energy extract and its preparation method and application |
| CN109056372A (en) * | 2018-06-27 | 2018-12-21 | 阜南美凯服饰有限公司 | A kind of coloring agent for cotton synthetic fibre fabric |
| CN111150811A (en) * | 2019-12-19 | 2020-05-15 | 艾散·阿尤普 | A kind of formula of hypoglycemic powder |
| CN113520888A (en) * | 2021-07-15 | 2021-10-22 | 广东雷诺化妆品研究院有限公司 | A kind of anti-aging composition containing fullerene and its preparation method and application |
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Application publication date: 20160907 |