CN105901001A - Bactericide composition containing metconazole and hymexazol - Google Patents

Abstract

The invention discloses a bactericide composition containing metconazole and hymexazol. The active components of the bactericide composition are metconazole and hymexazol, wherein the mass ratio of metconazole to hymexazol is 1:20 to 20:1, and the mass percentage of the active components in the composition is 5-60%. The bactericide composition has high bactericidal activity, delays the generation and development of drug resistance of pathogens, reduces the preventing and treating dosage in actual production, and is economical, efficient, safe and environment-friendly. The bactericide composition has better preventing and treating effects on multiple crop diseases caused by fusarium and has obvious preventing and treating effects on wheat scab.

Description

A kind of bactericidal composition containing metconazole and hymexazol

technical field

The invention relates to the field of agricultural fungicides, in particular to a fungicidal composition containing metconazole and hymexazol, which is used for preventing and treating wheat scab.

Background technique

Wheat head blight is a widely distributed disease, which occurs in almost all wheat producing areas in the world, especially in mild and humid and semi-humid areas. To date, there are no resistant wheat varieties with complete immunity to head blight. Therefore, wheat head blight still depends on chemical control in production. At present, the main agent used to control wheat head blight in production is the benzimidazole fungicide represented by carbendazim. Since the world's first carbendazim-resistant strain of Fusarium graminearum was detected on wheat ears in Haining, Zhejiang in 1992, the resistance of the pathogen has been found in Zhejiang, Jiangsu, Lu, Anhui and other places. Moreover, the proportion of drug-resistant bacteria is rapidly increasing, and the distribution of drug-resistant pathogenic bacteria continues to expand. At present, East China is facing the danger of failure of existing fungicides such as carbendazim to control scab due to drug resistance. How to continue to control wheat scab, especially the epidemic hazard of carbendazim-resistant scab has become a major issue faced by scientific and technological workers and growers.

Metconazole (Metconazole), also known as oxyconazole, chemical name: 5-(4-chlorophenyl)-2,2-dimethyl-1-(1,2,4-triazol-1-ylmethyl Base)-cyclopentanol, white, odorless crystal, is a new triazole fungicide developed by Kureha Chemical Company in Japan in the early 1990s, and is a C-14 demethylase inhibitor in ergosterol biosynthesis. The cell membrane function of the bacteria is destroyed. Therefore, inhibiting or interfering with the development of appressoria and haustoria, the formation of hyphae and spores can also lead to increased membrane leakage, thereby reducing the pathogenicity of pathogenic bacteria. Although the mechanism of action is the same as other triazole fungicides, the activity spectrum is quite different. Both isomers have bactericidal activity, but the activity of the cis form is higher than that of the trans form. The fungicidal spectrum of metconazole is very broad and its activity is excellent. Field application of metconazole has excellent effects on the plant diseases of Septoria, Fusarium and Puccinia of cereal crops. Compared with traditional fungicides, metconazole has a very low dose and a wide range of control of cereal plant diseases. Meconazole is a high-efficiency, broad-spectrum, systemic triazole fungicide with protective, therapeutic and eradicating effects, so it is widely used in the prevention and control of various diseases caused by fungi such as Ascomycetes and Basidiomycetes. Meconazole is currently one of the effective agents for the control of wheat scab. It can not only reduce the severity of wheat scab in the field, but also reduce the contamination of pathogenic toxins in diseased wheat grains and ensure food safety.

Meconazole molecular formula: C ₁₇ H ₂₂ C _l N ₃ O, structural formula:

Hymexaxzol is a systemic fungicide and plant growth regulator. It has significant control effects on various plant fungal diseases, such as Fusarium, seedling rot, Pythium, Rhizoctonia, Rhizoctonia, Snow Microbacteria, etc. It is widely used in rice, wheat, cotton, sugar beet, tobacco, vegetables , seedlings, fruit trees, cereals, oil family, melons, lawns, flowers and other crops caused by the above-mentioned pathogenic fungi. Strong soil sterilization and seed disinfection have special effects on various soil-borne diseases; promote crop growth and root development, and resist various physiological diseases and herbicide damage at the seedling stage.

The molecular formula of hymexazol is: C ₄ H ₅ NO ₂ , and the structural formula is:

The long-term use of metconazole and hymexazol in a single dose can easily lead to the development of drug resistance in diseases, leading to problems such as increased dosage, reduced control effect, and shortened duration, which is not conducive to sustainable development of the environment. The compounding of active ingredients with different action mechanisms is a common method to delay the development of drug resistance in diseases, and it is judged whether the compounding is synergistic or antagonistic according to the effect in actual production and application. The formula with obvious compounding effect can obviously improve the control effect, greatly reduce the dosage of pesticides, and can also expand the bactericidal spectrum and improve the bactericidal efficiency.

Contents of the invention

The invention provides a bactericidal composition containing metconazole and hymexazol, which has high bactericidal activity, delays the occurrence and development of drug resistance of pathogens, and reduces the total dosage per unit area, which is economical, efficient and environmentally friendly. It has special effects on the control of wheat head blight.

The present invention combines two types of fungicides with different action mechanisms and processes them into a preparation that is easy to use in production. Compared with the two components used alone, it has high biological activity, and the total dosage per unit area decreases, greatly reducing The application cost is reduced, and at the same time, the emergence and development of pathogenic drug resistance is delayed to a greater extent, the risk of pathogenic fungi developing resistance to a single fungicide is reduced, and the service life of each component in the fungicidal composition is extended, thereby achieving economical , efficient, and environmentally friendly invention purposes.

Technical scheme of the present invention is:

A fungicide composition containing metconazole and hymexazol, characterized in that, the active components of said fungicide composition are metconazole and hymexazol, and the mass ratio of metconazole and hymexazol is 1:20 to 20:1, the mass percentage of active components in the composition is 5-60%.

The bactericidal composition containing metconazole and hymexazol is characterized in that the mass ratio of the active components metconazole to hymexazol is 1:10 to 10:1.

The bactericidal composition containing metconazole and hymexazol is characterized in that the mass ratio of metconazole to hymexazol is 1:3-8.

The bactericidal composition containing metconazole and hymexazol is characterized in that the mass ratio of metconazole to hymexazol is 1:4-6.

The bactericide composition containing metconazole and hymexazol is characterized in that: the dosage form of the bactericide composition is wettable powder, suspension or emulsifiable concentrate.

The application of the fungicide composition containing metconazole and hymexazol is characterized in that: the fungicide composition has a higher control effect on various crop diseases caused by Fusarium, and has a higher control effect on wheat head blight Especially notable.

Significant effect and advantage of the present invention are:

The present invention has a higher control effect on wheat fungal diseases, and there is an obvious synergistic effect between the two components; it can replace some high-priced pesticide varieties, reduce the dosage, effectively reduce ecological damage and environmental pollution, and can improve wheat Yield and quality; both metconazole and hymexazol of the present invention are of low toxicity, and are safe to humans, animals, beneficial organisms, and the environment; and can delay the resistance of pathogens to single agents.

First measure the EC ₅₀ (drug safety index) of two single compounds (hereinafter referred to as medicaments) of metconazole and hymexazol, and set the combination ratio of the two medicaments according to the Wadley method according to the EC ₅₀ of the two single medicaments, and increase the effect according to Wadley Coefficient C value, to determine the appropriate composition ratio, and then according to Sun Yunpei method to be verified.

The test object is Fusarium rubella, but not limited thereto. The test adopts mycelial growth assay method, and the drug-containing medium is prepared according to different treatments. Each treatment has 4 repetitions. After inoculation for 3 days, the growth inhibitory effect of each treatment on wheat head blight was investigated. Through the linear regression analysis between the probability value of the control effect and the logarithmic value of the serial drug concentration, the EC50 of each drug was obtained, and the synergistic coefficient (SR) was calculated according to the Wadley method, and a comprehensive evaluation was made accordingly. SR≤0.5 means antagonistic effect, 0.5<SR<1.5 means additive effect, SR≥1.5 means synergistic effect. The calculation method of SR value is as follows:

EC ₅₀ (theoretical value)=(a+b)/(a/EC _50A +b/EC _50B )

SR＝EC ₅₀ (theoretical value)/EC ₅₀ (actual value)

SR ≤ 0.5, the two agents mixed with antagonistic effect

SR＝0.5～1.5, the mixture of two medicines has additive effect

SR ≥ 1.5, the combination of the two agents has a synergistic effect

Table 1 Meconazole and hymexazol composition to the Wadley method determination result of wheat head blight

Note: Y is metconazole, E is hymexazol.

From the above data, it can be analyzed that different ratios of metconazole and hymexazol compositions have different antibacterial effects on wheat head blight, generally speaking, the ratios range from 1:20 to 20:1. Synergistic or additive effect, wherein the maximum synergistic ratio is the ratio of metconazole and hymexazol is 5:1.

The present invention will be further described below in conjunction with the examples, but not limited thereto.

detailed description

Embodiment 1 (the preparation method of 60% metconazole hymexazol wettable powder)

Raw material formula: by mass percentage

Preparation method: uniformly mix the above-mentioned substances, and pulverize the mixture through a jet mill to obtain a wettable powder.

Embodiment 2 (the preparation method of 30% metconazole hymexazol suspension concentrate)

Preparation method: According to the formula, weigh each component in proportion, put it into a ball mill and mill it for 30 minutes, filter, pump it into the dispersion tank for 3 minutes, and then grind it fully with a sand mill to control the particle diameter of the solid component within 2 microns , Stir evenly after grinding to get the suspension product

Embodiment 3 (the preparation method of 40% metconazole hymexazol suspension concentrate)

Preparation method: same as Example 2.

Embodiment 4 (the preparation method of 20% metconazole·hymexazol emulsifiable concentrate)

Preparation method: fully dissolve the active component metconazole in a xylene reactor to make liquid A; fully dissolve the active component hymexazol in a xylene reactor to make liquid B; keep stirring Next, mix liquid A into liquid B, stir well, add anhydrous calcium salt and NP-10, and then adjust the content with solvent xylene.

Embodiment 5 (the preparation method of 45% metconazole · hymexazol emulsifiable concentrate)

Raw material formula: by mass percentage

Preparation method: with embodiment 4.

Embodiment 6 (the preparation method of 48% metconazole · hymexazol emulsifiable concentrate)

Raw material formula: by mass percentage

Preparation method: with embodiment 4.

Control effect test:

The field control effect test of wheat head blight was carried out in the suburbs of Bengbu City, the test area was 0.3hm ² , each treatment was repeated three times, spraying control was carried out at the flowering stage of wheat, and the control effect investigation was carried out 15 days after spraying. The control results are shown in the table 2. The results show that the fungicidal composition containing metconazole and hymexazol has a good control effect on wheat scab, and can achieve higher control effect at the same dosage or at a lower dosage, and each of the fungicidal composition The antibacterial bacteria treated were greater than 85%, which was significantly higher than that of the control agent.

Table 2 Field efficacy of metconazole·hymexazol fungicidal composition in controlling wheat head blight*

The field control experiment of rice bakanae disease was set up in the suburbs of Bengbu City, where rice bakanae disease occurred moderately every year on average, with a test area of 0.3hm ² , and each treatment was repeated three times. The volume ratio of the medicament mixture was 1:1, and the soaking time was 10 hours. The incidence of bakanae disease was investigated at the rice seedling stage, and the control results are shown in Table 3. The results show that the fungicidal composition containing metconazole and hymexazol has a good control effect on rice bakanae disease, and the control effect at each treatment dose is higher than 83%, which is significantly higher than that of the control agent.

Table 3 Field efficacy of metconazole·hymexazol fungicidal composition soaking treatment on rice bakanae disease (the volume ratio of seed and pesticide mixture is 1:1)*

From the data in Table 2 and Table 3, it can be seen that the fungicidal composition containing metconazole and hymexazol has good control effects on wheat head blight and rice bakanae disease caused by Fusarium, and different proportions of the control effect effect is different. It is worth noting that when the ratio of metconazole and hymexazol is 5:1, compared with other treatments, it has a higher control effect on the two diseases at a lower dosage, showing better The synergistic effect; and the indoor biotest results also showed that when the ratio of metconazole and hymexazol was 5:1, the measured synergistic coefficient was the highest, and the results of the two were consistent.

Finally, it should be noted that the above examples are only some specific embodiments of the present invention. Apparently, the present invention is not limited to the above embodiments, and many modifications are possible. All deformations that can be directly derived or associated by those skilled in the art from the content disclosed in the present invention are considered to be within the protection scope of the present invention.

Claims (6)

1. one kind contains metconazole and the bactericidal composition of mould spirit, it is characterised in that the active component of described microbicide compositions is metconazole and mould spirit, and the mass ratio of metconazole and mould spirit is 1:20 to 20:1, and in compositions, active component weight/mass percentage composition is 5-60%.

It is the most according to claim 1 containing metconazole with the bactericidal composition of mould spirit, it is characterised in that: described active component metconazole and the mass ratio of mould spirit are 1:10 to 10:1.

It is the most according to claim 1 containing metconazole with the bactericidal composition of mould spirit, it is characterised in that: the mass ratio of described metconazole and mould spirit is 1:3-8.

It is the most according to claim 1 containing metconazole with the bactericidal composition of mould spirit, it is characterised in that: the mass ratio of described metconazole and mould spirit is 1:4-6.

It is the most according to claim 1 and 2 containing metconazole with the microbicide compositions of mould spirit, it is characterised in that: the dosage form of described microbicide compositions is wettable powder, suspending agent or cream.

Microbicide compositions application containing metconazole and mould spirit the most according to claim 1 and 2, it is characterised in that: described bactericidal composition gibberella saubinetii microbial to reaping hook disease has the highest prevention effect.