CN1058888C - External-use ointment for treating pathological changes of intervertebral disc - Google Patents
External-use ointment for treating pathological changes of intervertebral disc Download PDFInfo
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- CN1058888C CN1058888C CN97106133A CN97106133A CN1058888C CN 1058888 C CN1058888 C CN 1058888C CN 97106133 A CN97106133 A CN 97106133A CN 97106133 A CN97106133 A CN 97106133A CN 1058888 C CN1058888 C CN 1058888C
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- 239000002674 ointment Substances 0.000 title claims abstract description 15
- 231100000915 pathological change Toxicity 0.000 title claims description 4
- 230000036285 pathological change Effects 0.000 title claims description 4
- 239000003814 drug Substances 0.000 claims abstract description 35
- 229940079593 drug Drugs 0.000 claims abstract description 22
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 12
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 12
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 11
- 241000218176 Corydalis Species 0.000 claims abstract description 10
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 9
- 241000252335 Acipenser Species 0.000 claims description 11
- 210000004712 air sac Anatomy 0.000 claims description 11
- 239000009286 sanguis draxonis Substances 0.000 claims description 11
- 241000972155 Moschus Species 0.000 claims description 10
- 239000003292 glue Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 229920000297 Rayon Polymers 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 claims 2
- 239000002994 raw material Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 17
- 239000011505 plaster Substances 0.000 abstract description 13
- 208000018650 Intervertebral disc disease Diseases 0.000 abstract description 6
- 239000002671 adjuvant Substances 0.000 abstract description 6
- 230000001225 therapeutic effect Effects 0.000 abstract description 5
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 abstract description 4
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract description 3
- 229940116229 borneol Drugs 0.000 abstract description 3
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract description 3
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract description 3
- 206010002198 Anaphylactic reaction Diseases 0.000 abstract description 2
- 206010027439 Metal poisoning Diseases 0.000 abstract description 2
- 208000031481 Pathologic Constriction Diseases 0.000 abstract description 2
- 239000000853 adhesive Substances 0.000 abstract description 2
- 230000001070 adhesive effect Effects 0.000 abstract description 2
- 208000003455 anaphylaxis Diseases 0.000 abstract description 2
- 208000008127 lead poisoning Diseases 0.000 abstract description 2
- 230000036262 stenosis Effects 0.000 abstract description 2
- 208000037804 stenosis Diseases 0.000 abstract description 2
- 239000011787 zinc oxide Substances 0.000 abstract description 2
- 241000220433 Albizia Species 0.000 abstract 1
- 241001313855 Bletilla Species 0.000 abstract 1
- 241000123589 Dipsacus Species 0.000 abstract 1
- 241001116742 Drynaria Species 0.000 abstract 1
- 241000402754 Erythranthe moschata Species 0.000 abstract 1
- 241000206672 Gelidium Species 0.000 abstract 1
- 241001252483 Kalimeris Species 0.000 abstract 1
- 241000913745 Spatholobus Species 0.000 abstract 1
- 229940126678 chinese medicines Drugs 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 108010059642 isinglass Proteins 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229910052627 muscovite Inorganic materials 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 208000012287 Prolapse Diseases 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 239000012567 medical material Substances 0.000 description 3
- 208000005198 spinal stenosis Diseases 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 2
- -1 Scorpio Chemical compound 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
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- 230000017531 blood circulation Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 229960001680 ibuprofen Drugs 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 206010025005 lumbar spinal stenosis Diseases 0.000 description 2
- 238000002636 symptomatic treatment Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 241000717739 Boswellia sacra Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 239000004863 Frankincense Substances 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 241001057584 Myrrha Species 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000571 coke Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
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- 239000012467 final product Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
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- 238000005469 granulation Methods 0.000 description 1
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- 238000010438 heat treatment Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
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- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
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- 239000003440 toxic substance Substances 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to externally applied ointment for treating intervertebral disc disorders and spinal canal stenosis. The present invention is characterized in that the externally applied ointment does not contain auxiliary materials and is made of pure Chinese medicines; isinglass, teasel root and rhizome of drynaria are used as principal medicines, common bletilla tuber and albizzia bark are used as ministerial medicines, rhizoma corydalis, chuanxiong rhizome, radix notoginseng, draconis resin, spatholobus stem, indian kalimeris herb and haw juice are used as adjuvant medicines, and musk and borneol are used to lead the principal medicines, the ministerial medicines and the adjuvant medicines to disease parts where the principal medicines, the ministerial medicines and the adjuvant medicines are used together. The present invention overcomes the defect that a black plaster pollutes skins and clothing and does not have the side effect of black plaster saturnism, zinc oxide anaphylactic reaction of an adhesive plaster, etc. The present invention has obvious effect of high therapeutic effect and short course of treatment and is worthy of popularizing.
Description
The invention belongs to a kind of Chinese medicine lotion for external use agent for the treatment of intervertebral disc disorder, be mainly used in pushing away that intercalated disc is given prominence to, deviate from, on the external application for curing of bulging, bulge, crypts and spinal canal stenosis.
Treatment at present pushes away the intercalated disc pathological changes, generally still adopt traction, massage, physical therapy method, but this method of treatment time is long, cure rate is low.Also have and adopt " ibuprofen " for oral administration, " wind is flat ", " ibuprofen " class treatment myalgia medicine, the painful sense that this can only reduction of patient, rather than the medicine of symptomatic treatment.This class disease of Chinese traditional treatment except that the Chinese medicine for oral administration prescription, also adopts the external application medical ointment interior disease outer treating method.As: in " " Yang Shi discutient and analgesic plaster " treatment prolapse of lumbar intervertebral disc 82 examples " article that " the Jiangsu traditional Chinese medical science " 1994 the 15th the 9th phases of volume deliver, disclose a kind of " Yang Shi discutient and analgesic plaster ", it is by Moschus, borneol, Scorpio, Sal Ammoniacus, Sanguis Draxonis, Radix Notoginseng, rhizoma sparganic, Rhizoma Curcumae, Dong Dan, Oleum Sesami is formed, its method for making is earlier with Radix Notoginseng, rhizoma sparganic, Rhizoma Curcumae is put into Oleum Sesami and was soaked three days, heat again wait to explode into medicinal residues are taken out again behind the coke yellow red down, behind fire, put into Moschus, borneol, Scorpio, Sal Ammoniacus, Sanguis Draxonis carefully not with spare into cream, its therapeutic effect is, in 82 routine prolapse of lumbar intervertebral disc patients, through controlling a course of treatment (one month), clinical cure 36 examples, remarkable 43 examples that take a turn for the better, invalid 3 examples, total effective rate is 96.3%, but its cure rate only 43.9% is still not ideal enough, and still belongs to traditional black plaster from its prescription and preparation technology.For another example, November 29 nineteen ninety-five, Patent Office of the People's Republic of China is with Granted publication CN1030373C, the disclosed patent No. is " medicine for waist rheumatism " patent of 93102774.8, this patent specification, a kind of medicine " medicine for waist rheumatism " for the treatment of prolapse of lumbar intervertebral disc and lumbar spinal stenosis is disclosed, it is made up of Flos Carthami, Lignum Sappan, Olibanum, Myrrha, Radix Sanguisorbae, Pollen Typhae, Radix Notoginseng, Herba Lycopi, Sanguis Draxonis, Lignum Dalbergiae Odoriferae, Rhizoma Corydalis, Semen Strychni, the Cortex Eucommiae etc. 30 flavor Chinese crude drugs, and has provided the Example formulations of three kinds of tablets of this patent of invention " medicine for waist rheumatism ", two kinds of electuaries, two kinds of plaster.Also disclose the therapeutic effect of taking medicine 1-3 month: 1, prolapse of lumbar intervertebral disc is treated 68 examples altogether, cures 57 examples, and cure rate is 83.8%, produce effects 8 examples, total effective rate 95.6%.2, lumbar spinal stenosis is treated 46 examples altogether, cures 38 examples, produce effects 5 examples, total effective rate 93.5%, cure rate 82.6%.But the case that the examination of this therapeutic effect is controlled is limited, and its popularity is not necessarily arranged, and undeclared be for oral administration be external, still for oral administration, external is executed altogether, should " medicine for waist rheumatism " the more deficiency of used taste of Chinese medicine number be arranged also itself simultaneously.
Purpose of the present invention is exactly the deficiency at above-mentioned external-applied ointment treatment intervertebral disc disorder, provides a kind of curative effect the high external-applied ointment that can treat multiple pathological changes of intervertebral disc and spinal stenosis.
The present invention realizes by the following technical solutions, is characterized in that it does not contain adjuvant, and is made up of pure Chinese crude drug that the ratio of weight and number of each Chinese crude drug of its prescription is:
Air Bladder pseudosciaenae seu Acipenser: 19-38, Radix Dipsaci and Rhizoma Drynariae are 12-24, and Pseudobulbus Bletillae (Rhizoma Bletillae) and Cortex Albiziae are 8-16, and Caulis Spatholobi and Rhizoma Chuanxiong are 6-12, and Rhizoma Corydalis, Radix Notoginseng and Herba Kalimeridis are 5-10, Fructus Crataegi juice: 70-140, Sanguis Draxonis and Borneolum Syntheticum are 1-2, Moschus: 0.1-0.2.
The concrete ratio of weight and number of forming various medical materials of the present invention is:
Air Bladder pseudosciaenae seu Acipenser: 35, Radix Dipsaci and Rhizoma Drynariae are 20, and Pseudobulbus Bletillae (Rhizoma Bletillae) and Cortex Albiziae are 9, and Caulis Spatholobi and Rhizoma Chuanxiong are 8, and Rhizoma Corydalis, Radix Notoginseng and Herba Kalimeridis are 7, Fructus Crataegi juice: 80, Sanguis Draxonis and Borneolum Syntheticum are 1.8, Moschus: 0.16.
By on be not difficult to find out that the functional characteristics of the technical program pharmaceutical formulation is: choosing and reusing the continuous muscle T-Ring of Air Bladder pseudosciaenae seu Acipenser, Radix Dipsaci, Rhizoma Drynariae the kidney invigorating nourishing the liver is monarch drug, joins Pseudobulbus Bletillae (Rhizoma Bletillae), the continuous muscle T-Ring detumescence and promoting granulation of Cortex Albiziae principal drug assistance is a ministerial drug; Select Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Notoginseng, Sanguis Draxonis, Caulis Spatholobi with promoting flow of QI and blood, the logical Lip river of blood stasis dispelling, reducing swelling and alleviating pain, the orchid that mates horses, Fructus Crataegi softening the hard mass disappear increase, heat-clearing and toxic substances removing is adjuvant drug altogether; Select Moschus, the hot perfume (or spice) of Borneolum Syntheticum to walk to scurry, saturating muscles and bones, the meridian dredging, promoting blood circulation to relieve pain, and draw the through sick be total to of all medicines for making.Because the technical program, be based on for many years research to intervertebral disc disorder mechanism, and constantly sum up and improve that prescription formulates out, it has embodied the kidney invigorating nourishing the liver Zhi Qiben, and promoting blood circulation to remove obstruction in the collateral, softening the hard mass relieve the pain and control its mark, the principle of this disease of radical cure of continuous muscle T-Ring Zhi Qigen, also since the technical program not only preferred embody the strong Chinese crude drug of above-mentioned Therapeutic Principle's function, and also science relatively of prescription consumption, so it has the curative effect height, the excellent effect of short treating period.This also can be with explanation from the situation of following trial edition ointment treatment intervertebral disc disorder patient 288 examples.
1, by patient's sex be: wherein male's 186 examples, women's 102 examples, cure 178 and 90 examples respectively, produce effects 8 and 12 examples add up to and cure 268 examples respectively, produce effects 20 examples, cure rate reaches 93%, produce effects 7%, effective percentage 100%.
2, press patient age section branch: in 16-40 year, 142 examples are cured 142 examples; In 41-60 year, 124 examples are cured 110 examples, produce effects 14 examples; 22 examples more than 61 years old are cured 16 examples, and produce effects 6 examples add up to as above.
3, by medical history length branch: 182 examples below 4 months, cure 182 examples; More than 4 months in 1 year 91 examples, cure 76 examples, produce effects 15 examples; 15 examples more than 1 year are cured 10 examples, and produce effects 5 examples add up to as above.
4, by the treatment time branch: 3-54 days, 230 examples were cured 230 examples, and 48 examples in 54-90 days are cured 34 examples, produce effects 14 examples; 10 examples more than 90 days are cured 4 examples, produce effects 6 examples.
The present invention is further described below in conjunction with embodiment, and about enforcement of the present invention, it is as follows to take by weighing clean Chinese crude drug respectively:
Air Bladder pseudosciaenae seu Acipenser 350g, Radix Dipsaci 200g, Rhizoma Drynariae 200g, each 90g of Pseudobulbus Bletillae (Rhizoma Bletillae) and Cortex Albiziae, each 80g of Caulis Spatholobi and Rhizoma Chuanxiong, each 70g of Rhizoma Corydalis, Radix Notoginseng and Herba Kalimeridis, each 18g of Sanguis Draxonis and Borneolum Syntheticum, Moschus 1.8g.
With Air Bladder pseudosciaenae seu Acipenser pulverize add water and even after, heating, it is aqueous to be viscose glue; Get clean Fructus Crataegi and be processed into Fructus Crataegi juice through fruit juice mixer, taking by weighing 800g inserts in the pot, 8 flavor meter 950g medicines such as the Radix Dipsaci that weighs up, Rhizoma Drynariae, Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Albiziae, Caulis Spatholobi, Rhizoma Chuanxiong, Rhizoma Corydalis, Radix Notoginseng, Herba Kalimeridis are put into the pot of Fructus Crataegi juice, add water (water yield is that the twice of medicine and Fructus Crataegi juice gets final product) again, be heated to and boil, heat is boiled half an hour, takes out medicinal residues, behind medical filtration, slow fire is endured to medicinal liquid and is the beading that drips again.With the powder of Air Bladder pseudosciaenae seu Acipenser glue and Sanguis Draxonis, Borneolum Syntheticum, Moschus three flavor medical materials, all put into the above-mentioned medicinal liquid of enduring and stir, promptly make ointment of the present invention.This ointment is coated on dehydration elastic force cloth (ointment bed thickness 0.4mm is advisable) after the sterilization with coating machine, cuts into the plaster shape, pack, standby plaster.The every subsides of this plaster were changed once in three days.Be not difficult to find out that from the foregoing description this ointment does not contain adjuvant, make that its substrate replaces with the medical material of this symptomatic treatment of Air Bladder pseudosciaenae seu Acipenser glue, and is water miscible by pure Chinese crude drug.So this ointment has also overcome the scarce limit that black plaster easily pollutes skin, medicated clothing, and the side effect such as zinc oxide anaphylaxis of black plaster lead poisoning, adhesive plaster with medicine.
Claims (2)
1, a kind of external-applied ointment for the treatment of the intervertebral pathological changes, it is characterized in that, its raw material and weight proportion are: Air Bladder pseudosciaenae seu Acipenser 19～38, Radix Dipsaci and Rhizoma Drynariae are 12～24, and Pseudobulbus Bletillae (Rhizoma Bletillae) and Cortex Albiziae are 8～16, and Caulis Spatholobi and Rhizoma Chuanxiong are 6～12, Rhizoma Corydalis, Radix Notoginseng and Herba Kalimeridis are 5～10, Fructus Crataegi juice 70～140, Sanguis Draxonis and Borneolum Syntheticum are 1～2, Moschus 0.1～0.2; Its preparation method is: Air Bladder pseudosciaenae seu Acipenser is pulverized added water and heat that to be viscose glue aqueous, Fructus Crataegi juice, Radix Dipsaci, Rhizoma Drynariae, Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Albiziae, Caulis Spatholobi, Rhizoma Chuanxiong, Rhizoma Corydalis, Radix Notoginseng, Herba Kalimeridis are inserted in the pot, in pot, add the heavy water of 2 times of medicines, be heated to and boil, heat is boiled half an hour, takes out medicinal residues, behind medical filtration, slow fire is endured to medicinal liquid and is the beading that drips again, the powder of Air Bladder pseudosciaenae seu Acipenser glue and Sanguis Draxonis, Borneolum Syntheticum, Moschus is added in the medicinal liquid of enduring stir promptly.
2. external-applied ointment as claimed in claim 1 is characterized in that its raw material and weight proportion are: Air Bladder pseudosciaenae seu Acipenser 35, and Radix Dipsaci and Rhizoma Drynariae are 20, Pseudobulbus Bletillae (Rhizoma Bletillae) and Cortex Albiziae are 9, and Caulis Spatholobi and Rhizoma Chuanxiong are 8, and Rhizoma Corydalis, Radix Notoginseng and Herba Kalimeridis are 7, Fructus Crataegi juice 80, Sanguis Draxonis and Borneolum Syntheticum are 1.8, Moschus 0.16.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97106133A CN1058888C (en) | 1997-10-06 | 1997-10-06 | External-use ointment for treating pathological changes of intervertebral disc |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97106133A CN1058888C (en) | 1997-10-06 | 1997-10-06 | External-use ointment for treating pathological changes of intervertebral disc |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1213541A CN1213541A (en) | 1999-04-14 |
| CN1058888C true CN1058888C (en) | 2000-11-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97106133A Expired - Fee Related CN1058888C (en) | 1997-10-06 | 1997-10-06 | External-use ointment for treating pathological changes of intervertebral disc |
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| Country | Link |
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| CN (1) | CN1058888C (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103356713B (en) * | 2013-07-29 | 2015-07-08 | 崔学君 | Acupoint sticking therapy externally-applied traditional Chinese medicinal plaster for treating peripheral facial paralysis, and preparation method thereof |
-
1997
- 1997-10-06 CN CN97106133A patent/CN1058888C/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 中医研究 1994.1.1 李长庚，药垫治疗腰椎间盘突出症 * |
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| Publication number | Publication date |
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| CN1213541A (en) | 1999-04-14 |
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