CN105879219A - Multi-channel high-voltage pulse power generator for transcranial magnetic stimulation - Google Patents

Abstract

A multi-channel high-voltage pulse power generator for transcranial magnetic stimulation, consisting of AC-DC modules, n groups of DC-DC boost modules (n≥2), n groups of energy storage-discharge switch modules (n≥2), main The control module consists of four parts. The AC-DC module converts the input AC voltage into a DC voltage and connects it to the input terminals of n groups of DC-DC step-up modules; n groups of DC-DC step-up modules convert the DC voltage output by the AC-DC module into n DC high voltage, supplying power to n energy storage capacitors in n groups of energy storage-discharge switch modules; n groups of energy storage-discharge switch modules discharge the external n stimulation coils under the control of the main control module; the main control module Through the data acquisition card interface, it is connected with the computer; under the control of the computer, the main control module controls the access and charging voltage of n groups of DC-DC modules, controls n groups of energy storage-discharge switch modules to discharge the stimulation coil, and the power supply The temperature/voltage status of the system is collected. The invention includes multiple charging power supply modules, multiple energy storage capacitors, multiple discharge control switches, and one equivalent to multiple high-voltage pulse power generators for transcranial magnetic stimulation, which can realize simultaneous stimulation of multiple coils, and can also be used separately for each coil Stimulate.

Description

Multi-channel high-voltage pulse power generator for transcranial magnetic stimulation

technical field

The invention belongs to the field of transcranial magnetic stimulation, in particular to a high-voltage pulse power generator for transcranial magnetic stimulation.

Background technique

Transcranial Magnetic Stimulation (TMS) was first created by British scholars such as Barker in 1985. It uses the induced electric field generated by the time-varying pulsed electromagnetic field to act on the central nervous system of the brain, changing the membrane potential of the cerebral cortical nerve cells and affecting the brain. It is a treatment method in the field of brain nerves that causes a series of physiological and biochemical reactions by controlling internal metabolism and nerve electrical activity. It has the advantages of no pain, no damage, and no X-ray radiation. With the development of computer technology, repetitive transcranial magnetic stimulation (Repeated TMS, rTMS) has gained more and more recognition in the fields of cognitive neuroscience, clinical neuropsychiatric diseases and rehabilitation. In 2002, it was approved for clinical application in Israel, and in 2008, it was approved by the US Food and Drug Administration (FDA) for drug-resistant depression. China State Drug Administration [2002] No. 302 approved the magnetic stimulator as a Class II medical electronic device.

Transcranial magnetic stimulation equipment is mainly composed of a high-voltage pulse power generator, a stimulating coil and a control computer. Its working principle is: the control computer issues charging/discharging instructions to the high-voltage pulse power generator; the high-voltage pulse power generator charges the internal energy storage capacitor during charging; the energy storage capacitor discharges the stimulation coil during discharge, generating a pulsed magnetic field, which acts on the brain. , generating an induced electric field.

The high-voltage pulse power generator is the core of the transcranial magnetic stimulation equipment. It mainly includes high-voltage pulse power, energy storage capacitors, thyristor switches, and reverse diodes. Its function is to accept computer control instructions, charge the energy storage capacitors, and control The storage capacitor is discharged.

Transcranial magnetic stimulation devices currently on the market consist of a high-voltage pulse power generator and a stimulating coil, such as Chinese patent CN101984548A. The disadvantage of this type of device is that a single device cannot stimulate multiple parts at the same time. Chinese patent CN101234231A proposes a magnetic stimulator with multiple stimulating coils, one of the features is that one device shares a high-voltage power supply, one energy storage capacitor, connected to multiple coils; the second feature is multiple power supplies, connected to multiple capacitors , multiple discharge switches and multiple coils. This structural system is complicated and the efficiency is reduced.

Contents of the invention

The present invention proposes a multi-channel high-voltage pulse power generator for transcranial magnetic stimulation. From the perspective of power supply design, each circuit module is integrated into a power generator, which reduces the complexity of the TMS system and reduces the cost of the TMS system. cost, improving the power efficiency of the system.

The present invention adopts following technical scheme to realize above-mentioned technical purpose:

A multi-channel high-voltage pulse power generator for transcranial magnetic stimulation, consisting of AC-DC modules, n groups of DC-DC boost modules (n≥2), n groups of energy storage-discharge switch modules (n≥2), main The control module consists of four parts. in,

The AC-DC module converts the input AC voltage into a DC voltage, which is characterized in that one AC input and n DC outputs are connected to the input terminals of n sets of DC-DC booster modules;

n sets of DC-DC step-up modules convert the DC voltage output by the AC-DC module into n channels of DC high voltage, and supply power to n energy storage capacitors in n sets of energy storage-discharge switch modules, which are characterized in that the DC-DC The access of the booster module is controlled by the control module, the output voltage range is adjustable from 0 to 2000V, and the output voltage value is controlled by the 0-10V DC voltage signal of the control board;

n groups of energy storage-discharge switch modules are characterized in that each group includes an energy storage capacitor, a thyristor discharge switch, and a protection diode, and the main control module controls each thyristor switch to be connected to the external stimulation coil discharge;

The main control module includes a data acquisition card interface, an optocoupler isolation circuit, and an acquisition and control circuit. It is characterized in that the acquisition card interface is connected with the computer, the control signal sent by the computer is isolated by the optocoupler, and after the signal acquisition control circuit processes, three control signals are sent out, and the main control module collects the temperature/voltage state of the power supply, and through the acquisition Card interface input to computer for processing.

As mentioned above, the three control signals sent by the main control module are characterized by: the first n-way high/low level signal controls whether n groups of DC-DC modules are connected or not; the second n-way 0~ 10V voltage signal, control the charging voltage range of n groups of DC-DC modules in the range of 0~2000V; the third output n-channel clock pulse signal, control the thyristor switches in n groups of energy storage-discharge switch modules to turn on, and the discharge frequency can be set 0~100Hz.

In the present invention, the input terminals of the n groups of DC-DC step-up modules are the same AC-DC module, which improves the overall efficiency of the power supply compared with the method of using multiple high-voltage power supplies (CN101984548A). According to the peak power consumption of each channel of 1.5KVA, the power consumption of the power generator of the present invention is above 3KVA (n≥2).

The multi-channel high-voltage pulse power generator for transcranial magnetic stimulation described in the present invention is completely independent in charging power supply, energy storage capacitor, discharge switch and stimulation coil, and can meet the needs of magnetic stimulation therapy in many aspects. One of the applications is that n coils correspond to n patients, and one device treats multiple patients at the same time. The second application uses n coils to simultaneously stimulate n parts for the same patient, expanding the application field of treatment. The third application is that n energy storage capacitors act on the same coil. By changing the discharge clock of each channel, the stimulation frequency is superimposed, and the stimulation frequency of a single coil is increased.

The present invention uses a multi-channel high-voltage pulse power generator to replace multiple power sources, increases the number of stimulations, reduces the complexity and cost of the TMS system, and expands the types and scope of treatments.

Description of drawings

Figure 1 is a structural block diagram of a multi-channel high-voltage pulse power generator for transcranial magnetic stimulation;

Figure 2a AC-DC circuit embodiment 1 described in Figure 1;

FIG. 2b AC-DC circuit embodiment 2 described in FIG. 1;

Fig. 3 is an implementation schematic diagram of a DC-DC step-up module circuit described in Fig. 1;

A schematic diagram of an energy storage-discharge switch module described in Fig. 1;

Fig. 5 is a functional block diagram of the implementation of the main control module described in Fig. 1 .

detailed description

The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

Figure 1 is a structural block diagram of a multi-channel high-voltage pulse power generator for transcranial magnetic stimulation. The working process of the present invention: the input alternating current is converted into direct current through the AC-DC module, and the direct current is divided into n circuits, and after passing through n groups of DC-DC step-up modules, it charges the capacitors in n groups of energy storage-discharging switch modules; the main The control module controls whether n groups of DC-DC step-up modules are connected, and controls the output voltage through the charging control signal of the main control module to charge the capacitor; under the control of the discharge clock issued by the computer, the n groups of energy storage-discharge switch modules are turned on The silicon controlled rectifier in is used to control n energy storage capacitors to discharge n stimulating coils.

Figure 2a is the AC-DC circuit embodiment 1, the AC rated input is 220V, the EMI circuit and the rectifier bridge are used to convert it into a DC with a nominal value of 300V, and it is divided into n circuits, through the switches K1, K2, ... , Kn, supplies power to the input stage of the DC-DC step-up module. The opening of the switches K1, K2, . . . , Kn is controlled by the main control module. The characteristic of this circuit is that the output DC voltage fluctuates greatly with the change of the load, between 200V and 310V, which makes it more difficult to adjust the voltage of the subsequent DC-DC booster module circuit.

Figure 2b is the second embodiment of the AC-DC circuit, the AC input is 90-260V, the EMI circuit, the rectifier bridge and the PFC circuit are used to convert it into a nominal value of 400V DC, and it is divided into n circuits, through the switches K1, K2, .. ...., Kn, supplies power to the input stage of the DC-DC step-up module. Embodiment 2 of the AC-DC circuit has a wide AC voltage input range, and is suitable for AC voltages of power grids in major countries around the world. The 400V output direct current has a small fluctuation range, which reduces the difficulty of adjusting the voltage of the subsequent DC-DC step-up module circuit.

FIG. 3 is a schematic diagram of an embodiment of a DC-DC step-up module circuit described in FIG. 1 . The invention realizes n-way high voltage output by n groups of circuits. For one of the channels, the input DC voltage passes through a full-bridge inverter circuit, a high-frequency transformer, and a high-frequency rectifier circuit to become a DC high voltage to charge the energy storage capacitor. Through the DC signal of 0-10V, the corresponding voltage regulation of 0-2000V is realized by adjusting the duty cycle of the PWM signal of the full-bridge inverter circuit. The implementation of the DC-DC step-up module is not limited to full-bridge inverters, but also half-bridge or other DC-DC topologies.

FIG. 4 is an implementation schematic diagram of an energy storage-discharge switch module described in FIG. 1 . The invention realizes an n-way energy storage-discharge switch module by n groups of circuits. For one of the roads, it includes an energy storage capacitor Cs, a thyristor discharge switch SCR, and a protection diode Dp. Each thyristor switch is controlled to open by a clock pulse signal sent by the main control module, and the clock pulse signal is 0~ 100Hz adjustable.

FIG. 5 is a functional block diagram of the main control module described in FIG. 1 . The main control module includes a data acquisition card interface, an optocoupler isolation circuit, and an acquisition and control circuit. The main control module receives the computer control signal through the interface of the acquisition card, and uploads the acquisition signal of voltage and temperature; the optocoupler isolation circuit realizes the signal isolation of the computer signal and the power supply; the acquisition and control circuit adjusts the three control signals sent by the computer to different functional module. Three kinds of control signals include: n-way high/low-level signal to control whether n groups of DC-DC modules are connected or not; n-way 0~10V voltage signal to control n groups of DC-DC module charging voltage range from 0 to 2000V ; n-way clock pulse signals to control the thyristor switches in n groups of energy storage-discharge switch modules to turn on. The acquisition and control circuit also adjusts the voltage and temperature signals and transmits them to the computer interface through the optocoupler.

Claims (3)

1. A multi-channel high-voltage pulse power generator for transcranial magnetic stimulation, consisting of AC-DC modules, n groups of DC-DC boost modules (n≥2), n groups of energy storage-discharge switch modules (n≥2) , The main control module consists of four parts. 2. According to the multi-channel high-voltage pulse power generator for transcranial magnetic stimulation according to claim 1, the AC-DC module is characterized in that one AC input and n DC outputs are connected to n groups of DC-DC boosters in parallel. The input end of the voltage module; n groups of DC-DC boost modules, characterized in that the access of the DC-DC boost module is controlled by the control module, the output voltage range is adjustable from 0 to 2000V, and the output voltage value is controlled by the control module The DC voltage signal of 0-10V on the board; n groups of energy storage-discharge switch modules, which are characterized in that each group includes an energy storage capacitor, a thyristor discharge switch, and a protection diode, and each thyristor switch is composed of The main control module sends a clock pulse signal to control the opening; the main control module includes a data acquisition card interface, an optocoupler isolation circuit, and an acquisition and control circuit, which is characterized by sending three control signals and collecting the temperature/voltage state of the power supply. 3. according to the three kinds of control signals sent by the main control module according to claim 2, it is characterized in that: the first n road high/low level signal controls whether the access of n groups of DC-DC modules is connected; the second One kind of n-way 0-10V voltage signal, to control the charging voltage range of n groups of DC-DC modules in the range of 0-2000V; the third one to output n-way clock pulse signal, to control the opening of thyristor switches in n groups of energy storage-discharge switch modules .