CN105878716A - Chinese herbal medicine compound preparation for preventing and treating chicken hydropericardium syndrome - Google Patents
Chinese herbal medicine compound preparation for preventing and treating chicken hydropericardium syndrome Download PDFInfo
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- CN105878716A CN105878716A CN201610370898.0A CN201610370898A CN105878716A CN 105878716 A CN105878716 A CN 105878716A CN 201610370898 A CN201610370898 A CN 201610370898A CN 105878716 A CN105878716 A CN 105878716A
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Abstract
本发明属于中兽药领域，特别公开了一种防治鸡心包积水综合征的中草药复方制剂。该中药以虎杖、柴胡、茵陈蒿、金钱草、枳壳、葶苈子、桑白皮、马鞭草、败酱、丹参、五味子、麦门冬、无花果叶、黄芪、甘草为活性成分，按一定的重量份数制成。本发明防治鸡心包积水综合征的中草药复方制剂，根据鸡心包积水综合征的发病机理和中兽医理论研制，在临床上取得了很好的效果；鸡服用后，既可以抗病毒，增强免疫力，又可以强心利尿，去除积水，还可以保肝护肾；治愈率高，对鸡心包积水综合征具有显著的防治效果。The invention belongs to the field of Chinese veterinary medicine, and particularly discloses a Chinese herbal medicine compound preparation for preventing and treating chicken hydropericardium syndrome. The traditional Chinese medicine uses Polygonum cuspidatum, Bupleurum, Artemisia capriculum, Desmodium citrifolia, Citrus aurantii, Tinglizi, Morus alba, Verbena, Patrin, Salvia miltiorrhiza, Schisandra, Ophiopogon japonicus, fig leaves, astragalus, and licorice as active ingredients. Made by certain parts by weight. The Chinese herbal medicine compound preparation for preventing and treating chicken hydropericardium syndrome of the present invention is developed according to the pathogenesis of chicken hydropericardium syndrome and the theory of traditional Chinese veterinary medicine, and has achieved good clinical results; Immunity, can strengthen the heart and diuresis, remove accumulated water, and protect the liver and kidney; the cure rate is high, and it has a significant preventive effect on chicken hydropericardium syndrome.
Description
(1) technical field
The invention belongs to field of traditional Chinese veterinary, particularly to a kind of medium-height grass recurrence due to taking drug preventing and treating chicken hydropericardium syndrome
Square preparation.
(2) background technology
In June, 2015, the area such as Shandong, Jiangsu broken out fast with death, mortality rate is high, pericardial effusion
The disease of the serum 4 type avian adenovirus infection being characterized, infection host include 817 broiler, laying hen, partridge chickens,
The kinds such as white meat-type chickens, Sanhuang chicken, common chicken, cut open inspection pathological changes visible: it is transparent that all dead chickens all show pericardium
Hydrops, measures bigger, and cardiac muscle is weak；Liver enlargement turns yellow, and frangible, have has necrosis；It is swollen that kidney has
Swollen turn white；After morbidity 4-8 days is peak mortality, course of disease 8-15 days, and mortality rate reaches 20～80%.Use city
On field, existing antiviral drugs effect is the most inconspicuous, and antibiotic is the most invalid, domestic current still without commercialization
Vaccine, chicken house is once fallen ill the most irremediable, causes serious economic loss to raiser.
(3) summary of the invention
The present invention is in order to make up the deficiencies in the prior art, it is provided that one is prepared simply, used safety, curative effect
Notable persistently, can with antiviral, strengthen immunologic function, again can with heart tonifying diuresis, remove hydrops, protect the liver and protect
The Chinese herbal compound preparation of the preventing and treating chicken hydropericardium syndrome of kidney.
The present invention is achieved through the following technical solutions:
A kind of Chinese herbal compound preparation preventing and treating chicken hydropericardium syndrome, its active component is by following weight portion
The raw material of number is made:
Rhizoma Polygoni Cuspidati 30-60 part, Radix Bupleuri 20-50 part, Herba Artemisiae Scopariae 5-15 part, Herba Lysimachiae 20-60 part, Fructus Aurantii 10-20
Part, Semen Lepidii (Semen Descurainiae) 30-50 part, Cortex Mori 30-50 part, Herba Verbenae 20-40 part, Herba Patriniae 25-40 part, pellet
Ginseng 10-30 part, Fructus Schisandrae Chinensis 10-20 part, Radix Ophiopogonis 10-20 part, common fig leaf juice 20-40 part, Radix Astragali 20-40
Part, Radix Glycyrrhizae 20-40 part.
The weight proportion of its preferred each active component is:
Rhizoma Polygoni Cuspidati 45 parts, Radix Bupleuri 35 parts, Herba Artemisiae Scopariae 10 parts, Herba Lysimachiae 40 parts, Fructus Aurantii 15 parts, Semen Lepidii (Semen Descurainiae)
40 parts, Cortex Mori 40 parts, Herba Verbenae 30 parts, Herba Patriniae 32 parts, Radix Salviae Miltiorrhizae 20 parts, Fructus Schisandrae Chinensis 15 parts, wheat
Door winter 15 parts, common fig leaf juice 30 parts, the Radix Astragali 30 parts, 30 parts of Radix Glycyrrhizae.
The dosage form of this Chinese herbal compound preparation is powder, oral liquid or granule.
The pharmaceutical characteristic of each active component of the present invention is as follows:
Rhizoma Polygoni Cuspidati: dampness removing jaundice eliminating, heat-clearing and toxic substances removing, eliminating stasis to stop pain, preventing phlegm from forming and stopping coughing.Modern study: blood pressure lowering, subtracts
Slow heart rate, strengthens myocardial contraction, cardioprotection, blood fat reducing；Suppression platelet aggregation, shock, change
Kind microcirculation；Antibacterial, antiviral, antioxidation；Relieving asthma, antitussive, calmness, analgesia, hemostasis, antiinflammatory.
Radix Bupleuri: have evacuation to bring down a fever, soothing liver-QI, the function of yang invigorating.For cold, fever, alternate attack of chill and fever, malaria,
Distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, the disease such as proctoptosis.Recent studies be used for treat influenza virus,
Disease caused by tubercule bacillus, plasmodium.
Herba Artemisiae Scopariae: clearing away heat-damp and promoting diuresis, jaundice eliminating.Herba Artemisiae Scopariae has significant hepatoprotective effect, has function of gallbladder promoting, promotes bile secretion,
Increase the effect that in bile, cholic acid and bilirubin are discharged.Heart coronary flow can be increased, improve microcirculation, and
Having blood pressure lowering, blood fat reducing, anticoagulation, diuresis is antipyretic relievings asthma, and drives away ascarid and suppresses multiple pathogenic dermatophytes
Effect with antibacterial.
Herba Lysimachiae: heat clearing away, dampness removing, treating stranguria, calculus, removing toxic substances.Cure mainly jaundice due to damp-heat, pyretic stranguria, nephritis water
Swollen, liver, gallbladder machine urinary system calculus, pyretic toxicity carbuncle.
Fructus Aurantii: regulating the flow of QI to ease the stomach, row stagnant relieving distension effect, cure mainly breast the side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion,
Stop in phlegm retention；Gastroptosis, proctoptosis.
Semen Lepidii (Semen Descurainiae): eliminating the pathogens from the lung sending down the abnormal ascending QI；Eliminating phlegm and relieving asthma；Inducing diuresis to remove edema；Let out and cure mainly by heresy: sputum stops up breathing heavily of lung
Expectoration is many；Lung abscess；Edema；Chest and abdomen hydrops；Dysuria；Chronic pulmonary heart disease；Heart failure it
Breathe heavily swollen.
Cortex Mori: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.Cure mainly lung-heat or diseases caused by retention of fluid stop the fullness in the chest of lung and breathes with cough, hemoptysis,
Edema, tinea pedis, dysuria.
Herba Verbenae: heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, inducing diuresis to remove edema.Control fever caused by exogenous pathogens, laryngopharynx swelling and pain, gingiva
Swell and ache, jaundice due to damp-heat, dysentery, malaria, gonorrhea, edema, dysuria, abdominal mass ulcerative carbuncle, toxic swelling, falls
Play damage.
Herba Patriniae: heat-clearing and toxic substances removing, detumescence and apocenosis, blood circulation promoting and blood stasis dispelling.Cure mainly acute appendicitis, lung abscess, dysentery, leukorrhagia,
Puerperal the stagnant stomachache of the stasis of blood, pyretic toxicity carbuncle.
Radix Salviae Miltiorrhizae: blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, evacuation of pus, pain relieving.Control angina pectoris, abdominal mass, accumulation, blood stasis
Stomachache, arthralgia, sleeplessness of palpitating with fear, malignant boil toxic swelling.
Blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, relieving restlessness calms the nerves, removing heat from blood eliminating carbuncle.Curing mainly trusted subordinate's pain, pyretic arthralgia swells and ache,
Traumatic injury, thermal man's nutrient blood, dysphoria, vexed insomnia, ulcerative carbuncle toxic swelling.
Fructus Schisandrae Chinensis: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, mind tranquilizing and the heart calming.Cure mainly chronic cough dyspnea due to deficiency, frequent urination and enuresis, for a long time
Rushing down more than, spontaneous sweating, Tianjin wound is thirsty, palpitation and insomnia.
Radix Ophiopogonis: nourishing YIN and moistening the lung, reinforcing stomach reg fluid, clear away heart-fire relieving restlessness.Cure mainly dryness of the lung dry cough, lung abscess, deficiency of YIN labor
Coughing, Tianjin wound is thirsty, quenches one's thirst, and vexed insomnia is had sore throat, and dryness of the intestine constipation, heat in blood tells nosebleed.
Common fig leaf juice: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Cure mainly diarrhea due to damp-heat, carbuncle pain, scrofula.
The Radix Astragali: benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening.Cure mainly all Qi and blood deficiencies it
Card, such as diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, proctoptosis, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle difficulty is burst or long
Burst and do not hold back.
Radix Glycyrrhizae: and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Process with controlling weakness of the spleen and stomach, asthenia lack of appetite,
Stomachache loose stool, extremity contraction urgency pain, cardiopalmus, hysteria, consumptive lung disease is coughed；Raw with controlling laryngopharynx swelling and pain, ulcerative carbuncle swells
Poison, infantile carbuncle, and medicine, alimentary toxicosis.
The present invention prevents and treats the Chinese herbal compound preparation of chicken hydropericardium syndrome, according to chicken hydropericardium syndrome
Pathogeny and Chinese veterinarian's theory develop, achieve good effect clinically；Preparation method is simple,
Multi-medicament is suitably coordinated, utilizes the collaborative or resistant function that it is mutual, improve curative effect, multiple to adapt to
The treatment requirement of miscellaneous diseases feelings, reduces untoward reaction, and evident in efficacy persistently absorption is fast, proves effective rapidly, effect
By force, nonirritant, safe and reliable, to take simple and convenient, medicine source is sufficient, affordable；After chicken takes,
Both can be with antiviral, enhancing immunity, hydrops can be removed, it is also possible to protect the liver and protect kidney with heart tonifying diuresis again；
Cure rate is high, and chicken hydropericardium syndrome is had significant prevention effect.
(4) detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but the invention is not limited in this, embodiment
In preparation method be customary preparation methods, no longer describe in detail.
Embodiment 1:
Weigh respectively Rhizoma Polygoni Cuspidati 45 grams, Radix Bupleuri 35 grams, Herba Artemisiae Scopariae 10 grams, Herba Lysimachiae 40 grams, Fructus Aurantii 15 grams,
Semen Lepidii (Semen Descurainiae) 40 grams, Cortex Mori 40 grams, Herba Verbenae 30 grams, Herba Patriniae 32 grams, Radix Salviae Miltiorrhizae 20 grams, Fructus Schisandrae Chinensis 15
Gram, Radix Ophiopogonis 15 grams, common fig leaf juice 30 grams, the Radix Astragali 30 grams, 30 grams of Radix Glycyrrhizae, after pulverizing and sieving, fill
Divide mix homogeneously, i.e. prepare the Chinese herbal medicine powder of this preventing and treating chicken hydropericardium syndrome.
Usage and dosage: be mixed in chicken feed by prepared powder, stir, every 1 kilogram of chicken feed is added
This powder 10 grams, is used in conjunction 7-14 days, and preventive dose halves.
Embodiment 2:
The Chinese herbal medicine powder of this preventing and treating chicken hydropericardium syndrome, its active component is by the raw material system of following weight
Become:
Rhizoma Polygoni Cuspidati 30 grams, Radix Bupleuri 20 grams, Herba Artemisiae Scopariae 5 grams, Herba Lysimachiae 20 grams, Fructus Aurantii 10 grams, Semen Lepidii (Semen Descurainiae)
30 grams, Cortex Mori 30 grams, Herba Verbenae 20 grams, Herba Patriniae 25 grams, Radix Salviae Miltiorrhizae 10 grams, Fructus Schisandrae Chinensis 10 grams, wheat
Door winter 10 grams, common fig leaf juice 20 grams, the Radix Astragali 20 grams, 20 grams of Radix Glycyrrhizae.
Preparation method and usage and dosage are with embodiment 1.
Embodiment 3:
Weigh respectively Rhizoma Polygoni Cuspidati 60 grams, Radix Bupleuri 50 grams, Herba Artemisiae Scopariae 15 grams, Herba Lysimachiae 60 grams, Fructus Aurantii 20 grams,
Semen Lepidii (Semen Descurainiae) 50 grams, Cortex Mori 50 grams, Herba Verbenae 40 grams, Herba Patriniae 40 grams, Radix Salviae Miltiorrhizae 30 grams, Fructus Schisandrae Chinensis 20
Gram, Radix Ophiopogonis 20 grams, common fig leaf juice 40 grams, the Radix Astragali 40 grams, 40 grams of Radix Glycyrrhizae, after pulverizing and sieving, fill
Divide mix homogeneously, prepare powder, powder is pulverized, adds water soaking at room temperature 4h of gross weight 6 times amount, boil
2h, filters；Medicinal residues add the water of gross weight 2 times amount again to be continued to boil 2h, filters and adds gross weight 2 times amount
Water, then boil 1h, merge 3 decocting liquids, after filtration, be concentrated into the crude drug Han 3g in every milliliter of medicinal liquid, i.e. make
Obtain the Chinese herbal medicament oral liquid of this preventing and treating chicken hydropericardium syndrome.
Usage and dosage: this oral liquid is mixed in drinking-water, every 1L water adds this oral liquid 3ml, freely drinks,
Being used in conjunction 7-14 days, preventive dose halves.
Embodiment 4:
Weigh respectively Rhizoma Polygoni Cuspidati 35 grams, Radix Bupleuri 30 grams, Herba Artemisiae Scopariae 8 grams, Herba Lysimachiae 30 grams, Fructus Aurantii 13 grams,
Semen Lepidii (Semen Descurainiae) 35 grams, Cortex Mori 36 grams, Herba Verbenae 25 grams, Herba Patriniae 30 grams, Radix Salviae Miltiorrhizae 15 grams, Fructus Schisandrae Chinensis 13
Gram, Radix Ophiopogonis 12 grams, common fig leaf juice 25 grams, the Radix Astragali 24 grams, 25 grams of Radix Glycyrrhizae, pulverize, add gross weight 6
Water soaking at room temperature 4h of times amount, boils 2h, filters；Medicinal residues add the water of gross weight 2 times amount again to be continued to boil
2h, filters and adds the water of gross weight 2 times amount, then boil 1h, merges 3 decocting liquids, after filtration, is condensed into
Paste, then in the paste extractum concentrated, add starch, mixing mixing, make soft material, pelletize, dry
Dry, i.e. prepare the Chinese herbal medicine granule (every 1g is equivalent to crude drug in whole 3g) of this preventing and treating chicken hydropericardium syndrome.
Usage and dosage: being mixed in drinking-water by this granule, dissolving stirs, adds this granule in every 1L water
Agent 3g, freely drinks, and is used in conjunction 7-14 days, and preventive dose halves.
Embodiment 5:
The Chinese herbal medicine granule of this preventing and treating chicken hydropericardium syndrome, its active component is by the raw material of following weight
Make:
Rhizoma Polygoni Cuspidati 55 grams, Radix Bupleuri 40 grams, Herba Artemisiae Scopariae 12 grams, Herba Lysimachiae 50 grams, Fructus Aurantii 18 grams, Semen Lepidii (Semen Descurainiae)
45 grams, Cortex Mori 44 grams, Herba Verbenae 35 grams, Herba Patriniae 35 grams, Radix Salviae Miltiorrhizae 25 grams, Fructus Schisandrae Chinensis 17 grams, wheat
Door winter 18 grams, common fig leaf juice 36 grams, the Radix Astragali 37 grams, 36 grams of Radix Glycyrrhizae.
Preparation method and usage and dosage are with embodiment 4.
For showing that the present invention prevents and treats the therapeutic effect of the Chinese herbal compound preparation of chicken hydropericardium syndrome, pass through
Tests below example is expanded on further the effect of Chinese herbal compound preparation of the present invention:
Clinical practice example:
1. prevention & protection test:
Subjects: in JIUYUE, 2015 Binzhou Prefecture outburst chicken hydropericardium syndrome, certain laying hen in this epidemic-stricken area
Plant, has 6 drylot feedings to support the blue brown laying hen in the age in days sea of 84 days, and cultivation scale is 14836.
Therapeutic regimen:
Test 1 group: in the case of original immune programme for children is constant, randomly choose 2 breeding houses, altogether 4982
Chicken, as testing 1 group, uses the granule of the embodiment of the present invention 4, mixed drink, adds this granule in every 1L water
Agent 3g, medication stops 5 days for 7 days, uses 1 month continuously, Continuous Observation 1 month again after drug withdrawal.
Test 2 groups: in the case of original immune programme for children is constant, randomly choose 2 breeding houses, altogether 4879
Chicken, as testing 2 groups, uses the oral liquid of the embodiment of the present invention 3, and mixed drink, every 1L water adds this oral liquid
3ml, medication stops 5 days for 7 days, uses 1 month continuously, Continuous Observation 1 month again after drug withdrawal.
Matched group: remain 2 breeding houses, altogether 4975 chickens, is specified by label description, uses other factory
The tcm product of family, uses 1 month continuously, Continuous Observation 1 month again after drug withdrawal.
Table 1 present invention prevention & protection result of the test to chicken hydropericardium syndrome:
As can be seen from Table 1, the present invention is used to prevent and treat the raising of Chinese herbal compound preparation of chicken hydropericardium syndrome
Supporting house, the death rate of chicken is significantly lower than matched group, and the present invention prevents and treats the medium-height grass recurrence due to taking drug of chicken hydropericardium syndrome
Square preparation is on the prevention & protection to chicken hydropericardium syndrome, and effect is notable.
2, therapeutic test: Jining plant, 42 age in days partridge chickens morbidities of raising, part chicken shows as adopting
Appetite reduces suddenly, lassitude, and dead fast, after dissection, heart adventitia has yellow or pale translucent
Liquid, liver enlargement, hemorrhage, kidney enlargement, hemorrhage, other organs all has damage in various degree, often
They dead tens, it is judged to the chicken caused by I group of serum 4 type aviadenovirus by clinical and laboratory diagnosis
Hydropericardium syndrome.Test chicken is equally divided into 4 groups (wherein three groups is test group, and one group is matched group),
Each group of individuality does not has notable difference, uses identical feeding manner in the environment of identical；
Test period: continuous use 10 days, observe 30 days；
Test method: test group 1-3, feeds the feedstuff being added with the made medicine of embodiment of the present invention 1-3 respectively；
Matched group: be mixed in chicken feed by Antiphlogistic Powder of Schizonepetae and Ledebouriellae, stir, to specifications, every 1kg chicken is raised
Material adds 4g Antiphlogistic Powder of Schizonepetae and Ledebouriellae, feeds to chicken；
Result of the test is as shown in table 2:
| Packet | Mortality rate | Cure rate |
| Test group 1 | 5.0% | 92% |
| Test group 2 | 12% | 82.5% |
| Test group 3 | 8% | 87% |
| Matched group | 33.0% | 62% |
As can be seen from Table 2, the use present invention prevents and treats the Chinese herbal compound preparation of chicken hydropericardium syndrome
Test group 1-3, the mortality rate of chicken is well below matched group, and cure rate is much higher than matched group, and the present invention prevents
Control the Chinese herbal compound preparation of chicken hydropericardium syndrome in the treatment to chicken hydropericardium syndrome, effect
Also highly significant.
Claims (3)
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