CN105854103B - A kind of continous way sampled plasma device - Google Patents
A kind of continous way sampled plasma device Download PDFInfo
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- CN105854103B CN105854103B CN201610255528.2A CN201610255528A CN105854103B CN 105854103 B CN105854103 B CN 105854103B CN 201610255528 A CN201610255528 A CN 201610255528A CN 105854103 B CN105854103 B CN 105854103B
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- 210000004369 blood Anatomy 0.000 claims abstract description 78
- 239000008280 blood Substances 0.000 claims abstract description 78
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 40
- 229940127219 anticoagulant drug Drugs 0.000 claims abstract description 40
- 230000010354 integration Effects 0.000 claims abstract description 40
- 239000007788 liquid Substances 0.000 claims abstract description 18
- 238000012544 monitoring process Methods 0.000 claims abstract description 16
- 238000000926 separation method Methods 0.000 claims abstract description 13
- 238000001514 detection method Methods 0.000 claims abstract description 9
- 238000012546 transfer Methods 0.000 claims description 49
- 210000002381 plasma Anatomy 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 7
- 230000002572 peristaltic effect Effects 0.000 claims description 4
- 206010067484 Adverse reaction Diseases 0.000 abstract description 6
- 230000006838 adverse reaction Effects 0.000 abstract description 6
- 239000000470 constituent Substances 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 14
- 230000008569 process Effects 0.000 description 13
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000007710 freezing Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
- A61M1/3644—Mode of operation
- A61M1/3646—Expelling the residual body fluid after use, e.g. back to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3672—Means preventing coagulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/0028—Special media to be introduced, removed or treated fluid entering a filter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- External Artificial Organs (AREA)
Abstract
The invention discloses a kind of continous way sampled plasma devices, including acquisition module, anti-coagulants module, separation module, collection module, transit module, loading module, anticoagulated whole blood pump line, component blood pump line and integration module, it is provided with multiple interfaces on integration module to be respectively connected with aforementioned each module and pump line, detection module and filter chamber are provided in integration module.Beneficial effects of the present invention：Realize the continous way separation and acquisition to blood constituent, the collecting flowchart required time is saved, it improves collecting efficiency and feeds back efficiency for the liquid of adverse reaction, implementing monitoring is carried out to whole device operating status simultaneously, improves safety, stability and the service life of device operation.
Description
Technical field
The present invention relates to a kind of medical apparatus, especially a kind of to be used for whole blood acquisition-separation-plasma collection-components back
Device.
Background technology
In sampled plasma process, after the completion of single cycle sampled plasma, component blood is not fed back directly, but is carried out
Component blood transfer, and anticoagulated whole blood carries out backup acquisition during transfer, the anti-freezing of backup acquisition when component blood is fed back
Whole blood enters separator and opens next separation cycle, referred to as continous way collecting flowchart.In continous way collecting flowchart, seperator
It can continue to rotate before sampled plasma amount reaches predetermined amount.
The acquisition process of continous way collecting flowchart and used device have the following problems in the prior art：
1. the process of acquisition is time-consuming longer, disposable isolated blood amount is larger, be easy to cause adverse reaction.
2. in gatherer process, the liquid for such as encountering fat slurry or processing adverse reaction needs just be fed back to by Centrifuge Cup
Human body, this flow reduce collecting efficiency, while being unfavorable for alleviating the adverse reaction of acquisition target as early as possible.
3. the monitoring modular of acquisition system is more and disperses, equipment volume is larger, and installation of the consumptive material on each monitoring modular is equal
It needs manually, to limit the efficiency of operating personnel.
4. in collecting flowchart, separation module working condition lacks pressure monitor means, is unfavorable for operating personnel's grasp and adopts
Collect situation.
Invention content
It is an object of the invention to：A kind of continous way sampled plasma device is provided, is realized by following technical proposals：
A kind of continous way sampled plasma device, including acquisition module, anti-coagulants module, separation module, collection module, transfer
Module, loading module, anticoagulated whole blood pump line, component blood pump line and integration module are provided with multiple interfaces difference on integration module
It is connected with aforementioned each module and pump line, detection module and filter chamber is provided in integration module.
Alternatively, acquisition module includes blood taking needle and three-way connector, the first branch and blood taking needle of three-way connector
It is connected, second, third branch is connected by interface with integration module respectively.
Alternatively, anti-coagulants module includes anti-coagulants pump line and anti-coagulants branch, and anti-coagulants branch connection anti-coagulants is deposited
It is provided with peristaltic pump on storage device, anti-coagulants branch and anticoagulated whole blood pump line.
Alternatively, separation module includes ring-separators and separator connecting tube, the head end and ring of separator connecting tube
The centre gangway of shape connector is connected, and the first of tail end is connected by interface with integration module respectively to third branch.
Alternatively, collection module includes blood plasma collecting bag and collection branch.
Alternatively, loading module includes loading branch, and loading branch connects liquid storage device by puncture needle.
Alternatively, transit module includes the first, second transfer bag and the first, second transfer branch.
Alternatively, channel is provided in integration module by anti-coagulants pump line, anti-coagulants branch and three-way connector
The second branch is connected, and air monitering module is provided on this channel；Simultaneously channel is provided with to lead to anticoagulated whole blood pump line, three
The third branch for connecing device is connected with filter chamber, and air monitering module and pressure monitoring module are provided on this channel；Integrated mould
Transfer chamber is additionally provided in block, transfer chamber passes through channel and filter chamber, the first transfer branch, loading branch and separator connecting tube
Third branch be connected；Channel is additionally provided in integration module by the second branch of separator connecting tube, component blood pump line,
Two transfer branches are connected with recirculation line, and recirculation line is connected with filter chamber simultaneously；Channel is additionally provided in integration module
The first branch of separator connecting tube is connected with branch is collected.
Alternatively, disengagement chamber is provided in the ring-separators, separator center is provided with to be connected with disengagement chamber
Logical centre gangway, centre gangway are provided with the dividing wall that one end is connected with outer wall, and centre gangway is divided into access road
With exit passageway, centre gangway is additionally provided with the baffle stretched out to outer wall, and exit passageway is divided into first outlet channel and the
Two exit passageways, access road are connected with separator connecting tube third branch, first outlet channel and separator connecting tube the
Two branches are connected, and second outlet channel is connected with the separator connecting tube first branch.
Alternatively, it is provided with stopper on the baffle, support plate is provided between centre gangway and internal chamber wall.
The method have the characteristics that：
1. be arranged by integration module internal structure, especially in integration module the structure setting of transfer chamber and with each section
The electronic valve setting of point connection, is opened and closed adjusting to electronic valve according to operating status, forms different fluid paths, make
Component blood when feeding back, can be carried out at the same time the centrifugation of blood, liquid and fat slurry can with direct feedback to human body, no longer pass through
By ring-separators, the feedback time of the time and liquid and fat slurry of acquisition process is greatly saved, improves collecting efficiency, together
When so that liquid is input to as early as possible in acquisition target body, reacted with improper release.
2. different from general cup type separator in the prior art, this programme uses distinctive annular centrifuge and sets
Meter, the opposite cup that centrifuges of capacity is relatively low, and annular release chamber and multi-passage design are used in structure, is connected by separator
Pipe realizes that triple channel is connect with module, is realized under system control and continues high-speed rotation, detached, detaching to blood constituent
In the process, blood plasma enters collecting bag, and component blood enters the second transfer bag by channel, then through recirculation line again through input channel
Human body is fed back, the anticoagulated whole blood to prestore in the first transfer bag at this time continues into ring-separators and detached, and ensures entire point
Continuity from process makes centrifuge shut down or dally without braking, substantially increases the efficiency of entire sampled plasma process,
Improve the service life of centrifuge.
3. being provided with air monitering module in integration module, the amount of liquid in anti-coagulants branch is monitored, monitoring is worked as
There is gas into fashionable, prompt operating personnel replacement anti-freezing agent storage device or progress circuit monitoring to anti-coagulants branch；Same space-time
Gas monitoring modular is monitored the fluid passage in integration module, and/feedback progress is inputted with the liquid confirmed in channel.
4. be additionally provided with pressure monitoring module in integration module, in fluid passage blood supply and feed back pressure and supervise
It surveys, ensures that whole process carries out in normally-pressured neighbor, such as exceed setting value, then prompt operating personnel to handle；Meanwhile
Pressure monitoring module is monitored pressure in ring-separators, and pressure anomaly in separator is avoided to cause to centrifuge leakage.
Beneficial effects of the present invention：The continous way separation and acquisition to blood constituent are realized, collecting flowchart institute has been saved
The time needed improves collecting efficiency and feeds back efficiency for the liquid of adverse reaction, while to whole device operating status
Implementing monitoring is carried out, safety, stability and the service life of device operation are improved.
Description of the drawings
Fig. 1 is the overall structure diagram of the present invention；
Fig. 2-Fig. 4 is the structural schematic diagram of ring-separators；
Fig. 5-Fig. 8 is the structural schematic diagram of integration module；
Fig. 9 is the operational flow diagram of whole device；
In figure, 1 is blood taking needle, and 2 be Active Interface, and 3 be three-way connector, and 3-1 to 3-3 is three-way connector first to the
Three branches, 4 be integration module, and 5-1 is anti-coagulants branch, and 5-2 is anti-coagulants pump line, and 5-3 is anti-coagulants puncture needle, and 6-1 is anti-
Solidifying agent flux controller, 6-2 are infusion drip controller, and 7 be anticoagulated blood pump line, and 8 be component blood pump line, and 9 is feed back branch,
10-1 is the first transfer branch, and 10-2 is the first transfer bag, and 11-1 is the second transfer branch, and 11-2 is the second transfer bag, 12-1
To collect branch, 12-2 is blood plasma collecting bag, and 13-1 is loading branch, and 13-2 is loading puncture needle, and 14 be separator connecting tube,
14-1 to 14-3 is separator connecting tube first to third branch, and 14-4 is jointing, and 15 be ring-separators, and 15-1 is
Separator outer wall, 15-2 are separator inner wall, and 15-3 is disengagement chamber, and 15-4 is centre gangway, and 15-5 is dividing wall, 15-6 be into
Mouth channel, 15-7 are baffle, and 15-8 is first outlet channel, and 15-9 is second outlet channel, and 15-10 is blend stop, and 15-11 is branch
Fagging, 15-12 are arc joint face, and 15-13 is cover board, and 15-14 is gap structure, and 16-1 to 16-17 is integration module first
To the 17th interface, 17-1 to 17-15 is the first to the tenth Five-channel of integration module, and 18 be filter chamber, and 19 be blood strainer,
20-1 to 20-2 is the first to the second air detection module, and 21-1 and 21-2 are the first, second pressure monitoring module, and 22-1 is extremely
22-10 is that integration module first to protelum point, 23 is transfer chamber.
Specific implementation mode
With reference to specific embodiments and the drawings, the present invention is further illustrated.
A kind of continous way sampled plasma device, including integration module 4 are provided with multiple interfaces on integration module, integrate mould
Detection module and filter chamber 18 are provided in block, a filter chamber part protrudes from outside integration module, and filter chamber is internally provided with
Blood strainer 19.
Acquisition module includes blood taking needle 1 and three-way connector 3, three-way connector first branch 3-1 by Active Interface 2 with
Blood taking needle 1 is connected, three-way connector the second branch 3-2 link block first interface 16-1, and three-way connector third branch connects
Connection module second interface 16-2.
Anti-coagulants module includes anti-coagulants branch 5-1 and anti-coagulants pump line 5-2, and anti-coagulants branch passes through anti-coagulants puncture needle
5-3 connection anti-coagulants storage devices.
Separation module includes ring-separators 15 and separator connecting tube 14, the jointing 14-4 of separator connecting tube with
The centre gangway 15-4 of ring-separators is connected, the first branch 14-1 of separator connecting tube by interface 16-14, second
Road 14-2 is connected by interface 16-17 with integration module by interface 16-15, third branch 14-3.
Collection module includes collecting branch 12-1 and blood plasma collecting bag 12-2, collects branch by interface 16-13 and integrates
Module is connected.
Transit module includes in the first transfer branch 10-1 and the first transfer bag 10-2, the second transfer branch 11-1 and second
Turn bag 11-2, the first transfer branch is connected by interface 16-10 with integration module by interface 16-8, the second transfer branch.
Loading module includes loading branch 13-1, loading branch by loading puncture needle 13-2 connection liquid storage devices,
And it is connected with integration module by interface 16-16.
It is both provided with peristaltic pump on anti-coagulants pump line 5-2 and anticoagulated whole blood pump line 7 and component blood pump line 8.
It is provided with first passage 17-1 in integration module anti-coagulants pump line is connected with three-way connector the second branch；The
Anti-coagulants pump line is connected by triple channel 17-3 with anti-coagulants branch；The first air detection module 20- is provided on third channel
1；Anticoagulated whole blood pump line is connected by second channel 17-2 with three-way connector third branch, and the second sky is provided on second channel
Gas detection module 20-2；Tenth Five-channel 17-15 connection anticoagulated whole blood pump lines, the tenth four-way 17-14 connection filter chambers bottom end,
Tenth Five-channel is connected with the tenth four-way by the 9th node 22-9；Fourth lane 17-4 connection filter chambers top, passes through
Third node 22-3 is connected with transfer chamber；Five-channel 17-5 is by second node 22-2 connection transfer chambers, while by connecing
Mouth 16-8 connection the first transfer branches；Tenth triple channel 17-13 passes through the tenth by the 8th node 29-8 connection transfer chambers
The third branch 14-3 of seven interface 16-17 connection separator connecting tubes is provided with second pressure monitoring modular in the tenth triple channel
21-2；12nd channel 17-12 passes through the 16th interface 16-16 and loading by the 7th node 22-7 connection transfer chambers
Branch is connected；Tenth channel 17-10 is by interface 16-14 and interface 16-13 by the first branch and receipts of separator connecting tube
Collection branch is connected, and fourth node 22-4 is provided on the tenth channel；Protelum point 22-10 is provided on 9th channel 17-9,
And the second branch of separator connecting tube is connected with component blood pump line with interface 16-15 by interface 16-12, the 9th channel
On be provided with the 5th node 22-5；11st channel 17-11 coordinator blood pump pipes, pass through the 6th node 22-6 and the 8th channel
17-8 is connected；7th channel 17-7 passes through interface by the tenth interface 16-10 connection the second transfer branches, the 6th channel 17-6
16-9 connections feed back branch 9, feed back branch and are arranged outside integration module, are connected with filter chamber protrusion outside integration module
It connects, the 6th channel, the 7th channel, the 8th channel form mutually threeway by first node.It is adjacent it to be provided with unicom in each node
The through-hole in two channels, through-hole are connected with electronic valve.
Separator is hollow cylindrical structure, and separator is arranged for double wall, between inner wall 15-2 and outer wall 15-1
Chamber constitutes the disengagement chamber 15-3 of annular, and separator center is provided with centre gangway 15-4, and centre gangway is provided with support
Plate 15-11 is connected with inner wall, and centre gangway is connected by fluidic connection channels with disengagement chamber, and fluidic connection channels are provided with
Fluidic connection channels are divided into access road 15-6 and exit passageway, liquid by the dividing wall 15-5 that one end is connected with outer wall
Interface channel is additionally provided with the baffle 15-7 stretched out to outer wall, and exit passageway is divided into first outlet channel 15-8 to be gone out with second
Mouth channel 15-9, disengagement chamber, centre gangway, interface channel tip height are concordant, and interface channel bottom is higher than disengagement chamber and center
The link position of channel, first outlet channel and disengagement chamber is provided with arc joint face 15-12.Baffle is close to the outer wall side end
It is provided with blend stop 15-10, separator further includes cover board 15-13, and cover board is set to above disengagement chamber that be combined into one with separator whole
Body, cover board are circle, and cover board, separator, centre gangway three's center line are located at same upright position, and the outer circumference diameter of cover board is big
In separator circle diameter.It is provided with the gap structure 15-14 to match with blend stop below cover board, cover board is combined with separator
Afterwards, blend stop is combined to form block with gap structure, block and disengagement chamber bottom and detaches cavity outer wall there are certain distances.Cover board
On be provided with card slot, mutually fixed with the buckle on centrifugal separator to be adapted to.
The workflow of the present invention is as shown in Figure 9：
1. acquisition：Blood taking needle is acquired the venipuncture of object, so that venous blood is entered by the effect of anticoagulated whole blood pump line
Three-way connector, while making that anti-coagulants passes through anti-coagulants branch and anti-coagulants pump line leads into three by the effect of anti-coagulants pump line
Device is connect, venous blood and anti-coagulants are mixed to form anticoagulated whole blood herein, enter filter chamber by the tenth Five-channel；
2. filtering：Into filter chamber anticoagulated whole blood after blood strainer filtering, put aside in filter chamber, pass through after product is full
Fourth lane enters transfer chamber, and the second, the 7th node is closed at this time, and anticoagulated whole blood is connected through third with eight nodes-separator
The third branch of pipe enters ring-separators access road；
3. separation：Anticoagulated whole blood is separated into red blood cell layer, tunica albuginea layer and blood plasma by ring-separators under centrifuge effect
Layer, due to each layer density difference, the plasma layer of density minimum is located at disengagement chamber innermost layer, and red blood cell layer and tunica albuginea layer are located at separation
Chamber outermost layer；
4. plasma collection：After annular release intracavitary blood plasma reaches a certain amount of, connected by first outlet channel-separator
The-the ten channels of the pipe first branch-collection branch-blood plasma collecting bag is collected；
5. component blood is collected：When being detected tunica albuginea layer in the first branch of separator connecting tube, that is, show to detach
Intracavitary blood plasma, which has been collected, to be finished, and the electronic valve of the connection fourth node on the tenth channel and protelum point through-hole is closed at this time,
Stop collecting blood plasma, the component blood in disengagement chamber is connected under component blood wriggling pumping action by second outlet channel-separator
Six the-the eight channels of node of the-the nine channels of pipe the second branch -11 channel-the of component blood pump line-the-first node-the seven is logical
The-the second transfer of road branch enters the second transfer bag；
6. backup acquisition：When carrying out component blood collection, blood taking needle continues to be acquired venous blood, while by anticoagulated whole
Blood enters transfer chamber after filter chamber filters, and the seven, the 8th nodes are closed at this time, and anticoagulated whole blood is logical by second node-the five
It is spare that the-the first transfer of road branch enters the first transfer bag；
7. transfer blood inputs：After component blood fully enters the second transfer bag in ring-separators, third node is closed,
8th node is opened, and the anticoagulated whole blood in the first transfer bag flows back to transfer chamber, then is inputted by the third channel of separator connecting tube
Ring-separators continue blood separation；
8. component blood is fed back：When transfer blood inputs ring-separators, filter chamber is vacant, and the 7th is connected in first node
The electronic valve of channel and the 8th tunnel holes is closed, and the component blood in the second transfer bag is through six channels of first node-the-feedback
Pipeline inputs filter chamber, and anticoagulated whole blood pump line acting in opposition makes component blood be fed back in human body；
9. liquid is fed back：When adverse reaction occurs for acquisition target, physiological saline/liquid passes through the tenth through loading branch
Two the-the seven nodes of branch enter transfer chamber, and the second, the 8th node is closed at this time, anticoagulated whole blood pump line acting in opposition, physiology salt
Water/liquid is fed back to human body by third node-filter chamber-anticoagulated whole blood pump line, is recycled when collecting flowchart enters last acquisition
When, blood plasma collecting bag reaches default acquisition target, and part residual is still arranged at disengagement chamber bottom after component blood is fed back, at this time physiological saline
Enter transfer chamber by the 12nd the-the seven node of channel, second, third node is closed, and liquid passes through the 8th the-the ten threeway of node
The third channel of road-separator connecting tube enters ring-separators, remaining component blood in separator is taken away, through second outlet
Nine channels of the second branch-the of channel-separator connecting tube -11 channel-the of component blood pump line-the, six the-the eight channel of node
Into first node, at this time the node closing in the 7th channel of unicom and the 8th channel, mixing liquid is through six channels-feedback pipe
Road-enters filter chamber, and under the effect of anticoagulated whole blood pump line in input human body, entire gatherer process terminates.
10. monitoring：In device operational process, the first air detection module being set on third channel is used for anti-freezing
Amount of liquid in agent branch is monitored, and when monitoring that anti-coagulants branch has gas into fashionable, operating personnel is prompted to replace anti-freezing
Agent storage device carries out circuit monitoring.The second air detection module being set on second channel is defeated for detecting anticoagulated whole blood
Enter and whether be mixed into air in the process, is closed more than the 9th node controlled if safety value on the tenth Five-channel as being mixed into air, temporarily
Stop whole flow process, and sends out alarm and reminding operating personnel and carry out pipeline investigation.It is additionally provided in second channel and the tenth triple channel
Pressure detecting module, to ensure that peristaltic pump runs well, is sent out for detecting the pressure condition in whole device if pressure anomaly
Go out alarm and reminding operating personnel and carries out pipeline investigation.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement etc., should all be included in the protection scope of the present invention made by within refreshing and principle.
Claims (1)
1. a kind of continous way sampled plasma device, which is characterized in that including acquisition module, anti-coagulants module, separation module is collected
Module, transit module, loading module, anticoagulated whole blood pump line, component blood pump line and integration module are provided on integration module multiple
Interface is connected with aforementioned each module and pump line respectively, and detection module and filter chamber are provided in integration module；
Acquisition module includes blood taking needle and three-way connector, and the first branch of three-way connector is connected with blood taking needle, and second,
Three branches are connected by interface with integration module respectively；
Anti-coagulants module includes anti-coagulants pump line and anti-coagulants branch, and anti-coagulants branch connects anti-coagulants storage device, anti-coagulants
It is provided with peristaltic pump on pump line, anticoagulated whole blood pump line and component blood pump line；
Separation module includes ring-separators and separator connecting tube, the head end of separator connecting tube and the center of annular connector
Channel is connected, and the first of tail end is connected by interface with integration module respectively to third branch；
Collection module includes blood plasma collecting bag and collection branch；
Loading module includes loading branch, and loading branch connects liquid storage device by puncture needle；
Transit module includes the first, second transfer bag and the first, second transfer branch；
It is provided with channel in integration module the second branch of anti-coagulants pump line, anti-coagulants branch and three-way connector is connected
It connects, air monitering module is provided on this channel；Channel is provided with by the third branch of anticoagulated whole blood pump line, three-way connector simultaneously
Road is connected with filter chamber, and air monitering module and pressure monitoring module are provided on this channel；It is additionally provided in integration module
Transfer chamber, the third branch phase that transfer chamber passes through channel and filter chamber, the first transfer branch, loading branch and separator connecting tube
Connection；Be additionally provided in integration module channel by the second branch of separator connecting tube, component blood pump line, the second transfer branch and
Recirculation line is connected, and recirculation line is connected with filter chamber simultaneously；Channel is additionally provided in integration module to connect separator
The first branch of pipe is connected with branch is collected;Each interface channel is connected with transfer chamber in integration module position and each
The position that interface channel connects each other is provided with connecting node, be provided in connecting node be connected with electronic valve it is logical
Hole;
Ring-separators are hollow cylindrical structure, and separator is arranged for double wall, and the chamber between inner and outer wall is constituted
The disengagement chamber of annular, separator center are provided with centre gangway, and centre gangway is provided with support plate and is connected with inner wall, in
Centre channel is connected by fluidic connection channels with disengagement chamber, and what fluidic connection channels were provided with that one end is connected with outer wall is isolated
Fluidic connection channels are divided into access road and exit passageway by wall, and fluidic connection channels are additionally provided with the gear stretched out to outer wall
Exit passageway is divided into first outlet channel and second outlet channel by plate, and disengagement chamber, centre gangway, interface channel top are high
Degree is concordant, and interface channel bottom is higher than disengagement chamber and centre gangway, and the link position of first outlet channel and disengagement chamber is provided with
Arc joint face;
Baffle is provided with blend stop close to the outer wall side end, and separator further includes cover board, and cover board is set to above disengagement chamber and divides
It is combined as a whole from device, cover board is circle, and cover board, separator, centre gangway three's center line are located at same upright position, is covered
The outer circumference diameter of plate is more than separator circle diameter;Be provided with the gap structure to match with blend stop below cover board, cover board with point
After being combined from device, blend stop is combined to form block with gap structure, block and disengagement chamber bottom and detaches cavity outer wall there are certain
Distance;It is provided with card slot on cover board, is mutually fixed with the buckle on centrifugal separator to be adapted to.
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| CN201610255528.2A CN105854103B (en) | 2016-04-22 | 2016-04-22 | A kind of continous way sampled plasma device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610255528.2A CN105854103B (en) | 2016-04-22 | 2016-04-22 | A kind of continous way sampled plasma device |
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| CN105854103B true CN105854103B (en) | 2018-10-09 |
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| CN1321106A (en) * | 1999-09-03 | 2001-11-07 | 巴克斯特国际公司 | Blood separation chamber with preformed blood flow passages and centralized connection to external tubing |
| CN1321098A (en) * | 1999-09-03 | 2001-11-07 | 巴克斯特国际公司 | Fluid pressure actuated blood pumping systems and methods with continuous inflow and pulsatile outflow conditions |
| CN1561234A (en) * | 2001-10-01 | 2005-01-05 | 巴斯福股份公司 | Highly swellable hydrogels with acid centers |
| CN1743016A (en) * | 2004-09-03 | 2006-03-08 | 特拉科斯有限公司 | Blood separation apparatus and its using method |
| CN206007684U (en) * | 2016-04-22 | 2017-03-15 | 四川南格尔生物科技有限公司 | A kind of continuous way sampled plasma device |
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2016
- 2016-04-22 CN CN201610255528.2A patent/CN105854103B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1321106A (en) * | 1999-09-03 | 2001-11-07 | 巴克斯特国际公司 | Blood separation chamber with preformed blood flow passages and centralized connection to external tubing |
| CN1321098A (en) * | 1999-09-03 | 2001-11-07 | 巴克斯特国际公司 | Fluid pressure actuated blood pumping systems and methods with continuous inflow and pulsatile outflow conditions |
| CN1561234A (en) * | 2001-10-01 | 2005-01-05 | 巴斯福股份公司 | Highly swellable hydrogels with acid centers |
| CN1743016A (en) * | 2004-09-03 | 2006-03-08 | 特拉科斯有限公司 | Blood separation apparatus and its using method |
| CN206007684U (en) * | 2016-04-22 | 2017-03-15 | 四川南格尔生物科技有限公司 | A kind of continuous way sampled plasma device |
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| Publication number | Publication date |
|---|---|
| CN105854103A (en) | 2016-08-17 |
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